1462:
333:
310:
207:
232:
591:
584:
339:
238:
48:
1499:. Cyclin D1 is a protein required for progression through the G1 phase of the cell cycle. During the G1 phase, it is synthesized rapidly and accumulates in the nucleus, and is degraded as the cell enters the S phase. Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. The protein dimerizes with CDK4/6 to regulate the G1/S phase transition and entry into the S-phase.
1403:
The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). It is 13,388 base pairs long, and translates into 295 amino acids. Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem
1609:
Chromosomal translocation around the cyclin D1 gene locus is often seen in B mantle cell lymphoma. In mantle cell lymphoma, cyclin D1 is translocated to the IgH promoter leading to cyclin D1 overexpression. Chromosomal translocation of the cyclin D1 gene locus is also observed in 15β20% of multiple
1558:
Cyclin D1 overexpression has been shown to correlate with early cancer onset and tumor progression and it can lead to oncogenesis by increasing anchorage-independent growth and angiogenesis via VEGF production. Cyclin D1 overexpression can also down-regulate Fas expression, leading to increased
1519:
Independent of CDK, cyclin D1 binds to nuclear receptors (including estrogen receptor Ξ±, thyroid hormone receptor, PPARΞ³ and AR ) to regulate cell proliferation, growth, and differentiation. Cyclin D1 also binds to histone acetylases and histone deacetylases to regulate cell proliferation and cell
1528:
Increasing cyclin D1 levels during the G1 phase is induced by mitogenic growth factors primarily through Ras-mediated pathways, and hormones. These Ras-mediated pathways lead to the increase in transcription of cyclin D1, and inhibit its proteolysis and export from the nucleus. Cyclin D1 is
1507:
The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). Cyclin D1-CDK4 inhibits pRb through phosphorylation, allowing E2F transcription factors to transcribe genes required for entry into the S phase. Inactive pRb allows cell cycle
74:
1605:
Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. Overexpression of Cyclin D1b, an isoform, is also present in breast and prostate cancers.
3252:
Shintani M, Okazaki A, Masuda T, Kawada M, Ishizuka M, Doki Y, Weinstein IB, Imoto M (2002). "Overexpression of cyclin DI contributes to malignant properties of esophageal tumor cells by increasing VEGF production and decreasing Fas expression".
4435:
Mori J, Takahashi-Yanaga F, Miwa Y, Watanabe Y, Hirata M, Morimoto S, Shirasuna K, Sasaguri T (November 2005). "Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma".
1508:
progression through the G1/S transition and allows for DNA synthesis. Cyclin D1-CDK4 also enables the activation of cyclin E-CDK2 complex by sequestering Cip/Kip family CDK inhibitory proteins p21 and p27, allowing entry into the S phase.
3370:
Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, Ferzli G, Johnson K, Fricke S, Diba F, Kallakury B, Ohanyerenwa C, Chen M, Ostrowski M, Hung MC, Rabbani SA, Datar R, Cote R, Pestell R, Albanese C (May 2007).
2362:
Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R (July 2006).
5640:
Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, Neumeister P, Novikoff PM, Brownlee M, Scherer PE, Jones JG, Whitney KD, Donehower LA, Harris EL, Rohan T, Johns DC, Pestell RG (September 2003).
1494:
Cyclin D1 was originally cloned as a breakpoint rearrangement in parathyroid adenoma and was shown to be required for progression through the G1 phase of the cell cycle to induce cell migration, angiogenesis and to induce the
1437:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs
3643:
Jin M, Inoue S, Umemura T, Moriya J, Arakawa M, Nagashima K, Kato H (November 2001). "Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II".
6230:
Seto M, Yamamoto K, Iida S, Akao Y, Utsumi KR, Kubonishi I, Miyoshi I, Ohtsuki T, Yawata Y, Namba M (July 1992). "Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation".
4106:
Kenny FS, Hui R, Musgrove EA, Gee JM, Blamey RW, Nicholson RI, Sutherland RL, Robertson JF (August 1999). "Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer".
4078:
Hodges LC, Cook JD, Lobenhofer EK, Li L, Bennett L, Bushel PR, Aldaz CM, Afshari CA, Walker CL (February 2003). "Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells".
1442:). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
6208:
Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ (February 1992). "Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas".
6385:
Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM (June 1984). "Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation".
1643:
Retinoid mediated cyclin D1 degradation via the ubiquitin proteolytic pathway; Differentiation-inducing factor-1 (DIF-1) induced ubiquitin-dependent degradation; Inhibition of cyclin D1 protein synthesis
2456:
Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ (October 1992). "Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins".
3942:
Hibberts NA, Simpson DJ, Bicknell JE, Broome JC, Hoban PR, Clayton RN, Farrell WE (August 1999). "Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors".
6497:
Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S (September 1995). "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas".
3056:
Peeper DS, Upton TM, Ladha MH, Neuman E, Zalvide J, Bernards R, DeCaprio JA, Ewen ME (March 1997). "Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein".
6179:
Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (July 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes".
2076:
Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (July 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes".
1458:. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
6423:
Hall M, Bates S, Peters G (October 1995). "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins".
3833:
Gansauge S, Gansauge F, Ramadani M, Stobbe H, Rau B, Harada N, Beger HG (May 1997). "Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis".
3806:
Bartkova J, Lukas J, MΓΌller H, Strauss M, Gusterson B, Bartek J (February 1995). "Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer".
2608:
Wang C, Li Z, Fu M, Bouras T, Pestell RG (2004). "Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential".
3679:
Yamanouchi H, Furihata M, Fujita J, Murakami H, Yoshinouchi T, Takahara J, Ohtsuki Y (January 2001). "Expression of cyclin E and cyclin D1 in non-small cell lung cancers".
3714:
Ikeguchi M, Sakatani T, Ueta T, Kaibara N (September 2001). "Cyclin D1 expression and retinoblastoma gene protein (pRB) expression in esophageal squamous cell carcinoma".
346:
245:
5460:
Fu M, Wang C, Rao M, Wu X, Bouras T, Zhang X, Li Z, Jiao X, Yang J, Li A, Perkins ND, Thimmapaya B, Kung AL, Munoz A, Giordano A, Lisanti MP, Pestell RG (August 2005).
6534:
Motokura T, Arnold A (June 1993). "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint".
4134:
Amin HM, McDonnell TJ, Medeiros LJ, Rassidakis GZ, Leventaki V, O'Connor SL, Keating MJ, Lai R (April 2003). "Characterization of 4 mantle cell lymphoma cell lines".
6062:
Gautschi O, Ratschiller D, Gugger M, Betticher DC, Heighway J (January 2007). "Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation".
2555:
Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides RJ (February 1997). "CDK-independent activation of estrogen receptor by cyclin D1".
6593:
4310:
Dragnev KH, Petty WJ, Shah S, Biddle A, Desai NB, Memoli V, Rigas JR, Dmitrovsky E (December 2005). "Bexarotene and erlotinib for aerodigestive tract cancer".
4220:"Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels"
2901:"Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1"
4218:
Specht K, Haralambieva E, Bink K, Kremer M, Mandl-Weber S, Koch I, Tomer R, Hofler H, Schuuring E, Kluin PM, Fend F, Quintanilla-Martinez L (August 2004).
4718:
Knudsen KE, Cavenee WK, Arden KC (May 1999). "D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability".
1907:
Motokura T, Bloom T, Kim HG, JΓΌppner H, Ruderman JV, Kronenberg HM, Arnold A (April 1991). "A novel cyclin encoded by a bcl1-linked candidate oncogene".
1114:
168:
6885:
6779:
6025:
Walker JL, Assoian RK (September 2005). "Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression".
3551:
Jares P, Colomer D, Campo E (October 2007). "Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics".
1095:
1582:
Cyclin D1 overexpression is correlated with shorter cancer patient survival and increased metastasis. Amplification of the CCND1 gene is present in:
5791:
Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (May 1993). "Physical interaction of the retinoblastoma protein with human D cyclins".
3759:"Dysregulated cyclin D1 expression early in head and neck tumorigenesis: in vivo evidence for an association with subsequent gene amplification"
4748:
Wang C, Fan S, Li Z, Fu M, Rao M, Ma Y, Lisanti MP, Albanese C, Katzenellenbogen BS, Kushner PJ, Weber B, Rosen EM, Pestell RG (August 2005).
7091:
3877:
3429:
2625:
1886:
4942:
Serrano M, Hannon GJ, Beach D (December 1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4".
6825:
1868:
2705:"Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner"
3005:
Mulcahy LS, Smith MR, Stacey DW (1985). "Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells".
332:
1329:
1322:
4893:
Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (November 1999).
6586:
4396:"Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells"
3455:"Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells"
3176:
Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S (2021-04-29).
1958:
Lew DJ, DuliΔ V, Reed SI (September 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast".
2852:"Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment"
2651:"Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment"
1450:, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein
309:
3412:
Amanatullah DF, Zafonte BT, Albanese C, Fu M, Messiers C, Hassell J, Pestell RG (2001). "Ras regulation of cyclin D1 promoter".
2209:
1855:
1834:
5511:"PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b"
5202:
Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME (September 1997).
4514:"The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes"
3331:"Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway"
2313:
Holnthoner W, Pillinger M, Groger M, Wolff K, Ashton AW, Albanese C, Neumeister P, Pestell RG, Petzelbauer P (November 2002).
1734:
231:
206:
5047:"Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1"
1851:
5096:"Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells"
71:
1788:
2114:
Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL (July 2011). "Cyclin D as a therapeutic target in cancer".
1830:
6579:
2264:
Neumeister P, Pixley FJ, Xiong Y, Xie H, Wu K, Ashton A, Cammer M, Chan A, Symons M, Stanley ER, Pestell RG (May 2003).
1461:
148:
3757:
Izzo JG, Papadimitrakopoulou VA, Li XQ, Ibarguen H, Lee JS, Ro JY, El-Naggar A, Hong WK, Hittelman WN (November 1998).
6895:
4998:"Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence"
3453:
Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG, Kanakura Y (March 1999).
1746:
1672:
4792:
Casimiro MC, Wang C, Li Z, Di Sante G, Willmart NE, Addya S, Chen L, Liu Y, Lisanti MP, Pestell RG (September 2013).
345:
244:
7036:
6739:
5690:
Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG (November 2010).
5403:"Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function"
4013:
Fantl V, Smith R, Brookes S, Dickson C, Peters G (1993). "Chromosome 11q13 abnormalities in human breast cancer".
3282:"Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation"
3122:"The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention"
338:
237:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
1704:
1698:
1496:
1447:
1443:
2703:
Reutens AT, Fu M, Wang C, Albanese C, McPhaul MJ, Sun Z, Balk SP, JΓ€nne OA, Palvimo JJ, Pestell RG (May 2001).
1159:
156:
5401:
Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, Pestell RG (August 2006).
4669:
Petre-Draviam CE, Williams EB, Burd CJ, Gladden A, Moghadam H, Meller J, Diehl JA, Knudsen KE (January 2005).
5953:
Jain S, Khuri FR, Shin DM (2004). "Prevention of head and neck cancer: current status and future prospects".
5509:
Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C, Pestell RG (January 2011).
4843:"GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity"
6686:
6136:"Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest"
1710:
1439:
1140:
4473:"Mechanism of cycloheximide inhibition of protein synthesis in a cell-free system prepared from rat liver"
1776:
1618:
Cyclin D1 and the mechanisms it regulates have the potential to be a therapeutic target for cancer drugs:
1455:
1451:
5643:"Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation"
5153:
Coleman KG, Wautlet BS, Morrissey D, Mulheron J, Sedman SA, Brinkley P, Price S, Webster KR (July 1997).
4394:
Boyle JO, Langenfeld J, Lonardo F, Sekula D, Reczek P, Rusch V, Dawson MI, Dmitrovsky E (February 1999).
3504:"Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions"
7018:
6769:
220:
5836:"Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription"
6457:
6395:
6265:
5917:
5414:
5107:
4951:
3189:
3065:
3014:
2961:
2950:"Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein"
2801:
1916:
1807:
1511:
Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators.
1476:
1469:
2225:"Expression and significance of Wnt signaling components and their target genes in breast carcinoma"
135:
6446:"Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C"
5354:"Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1"
1802:
1538:
1305:
1254:
5601:"Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation"
5462:"Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism"
7031:
6836:
6559:
6522:
6330:
6122:
6050:
6013:
5941:
5865:
5816:
5773:
5491:
5334:
5285:
5184:
5076:
5027:
4975:
4872:
4700:
4613:
4376:
4292:
4249:
4200:
3995:
3788:
3739:
3596:"Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma"
3576:
3533:
3231:
3099:
3038:
2987:
2881:
2680:
2590:
2534:
2482:
2344:
2191:
2139:
1983:
1940:
180:
4267:
Musgrove EA (March 2006). "Cyclins: roles in mitogenic signaling and oncogenic transformation".
3901:
Simpson DJ, Frost SJ, Bicknell JE, Broome JC, McNicol AM, Clayton RN, Farrell WE (August 2001).
1301:
1280:
1250:
1229:
2315:"Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells"
7026:
6551:
6514:
6485:
6432:
6411:
6373:
6322:
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4924:
4864:
4823:
4771:
4727:
4692:
4648:
4605:
4570:
4553:
Vigushin DM, Coombes RC (January 2002). "Histone deacetylase inhibitors in cancer treatment".
4535:
4494:
4453:
4417:
4368:
4327:
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4116:
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2183:
2131:
2093:
2058:
1975:
1932:
1680:
590:
128:
64:
5744:"Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity"
4631:
Shapiro GI (April 2006). "Cyclin-dependent kinase pathways as targets for cancer treatment".
3903:"Aberrant expression of G(1)/S regulators is a frequent event in sporadic pituitary adenomas"
6543:
6506:
6475:
6465:
6403:
6363:
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6314:
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5703:
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4407:
4358:
4319:
4276:
4231:
4182:
4143:
4052:
3979:
3914:
3865:
3862:
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
3770:
3723:
3688:
3653:
3615:
3607:
3560:
3515:
3474:
3466:
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2123:
2085:
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2040:
1967:
1924:
1542:
1483:
425:
356:
300:
255:
6252:
Rosenberg CL, Wong E, Petty EM, Bale AE, Tsujimoto Y, Harris NL, Arnold A (November 1991).
4588:
Lapenna S, Giordano A (July 2009). "Cell cycle kinases as therapeutic targets for cancer".
2001:
1722:
583:
176:
5966:
5094:
Cariou S, Donovan JC, Flanagan WM, Milic A, Bhattacharya N, Slingerland JM (August 2000).
400:
5204:"Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4"
2790:"P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor"
6461:
6399:
6269:
5921:
5418:
5111:
4955:
3502:
Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG (October 1995).
3193:
3069:
3018:
2965:
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1920:
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6135:
5716:
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5535:
5510:
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3121:
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2364:
47:
6368:
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5203:
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4513:
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3657:
3421:
3306:
3281:
2974:
2949:
2925:
2900:
2568:
2290:
2265:
2053:
2028:
1419:
cyclin box domain for cyclin-dependent kinase (CDK) binding and CDK inhibitor binding;
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
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759:
743:
738:
733:
728:
723:
718:
713:
708:
703:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
7085:
6965:
6480:
6445:
6318:
6288:
6253:
6192:
5804:
5658:
5130:
5095:
4566:
3611:
3373:"ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo"
3235:
2850:
Fu M, Rao M, Bouras T, Wang C, Wu K, Zhang X, Li Z, Yao TP, Pestell RG (April 2005).
2824:
2789:
2649:
Fu M, Rao M, Bouras T, Wang C, Wu K, Zhang X, Li Z, Yao TP, Pestell RG (April 2005).
2470:
2089:
1971:
1572:
mutations in the degradation motif recognized by the CRL4-AMBRA1 E3 ubiquitin ligase;
1562:
An abundance of cyclin D1 can be caused by various types of deregulation, including:
1428:
threonine residue (threonine 286) that controls nuclear export and protein stability.
619:
6563:
6526:
6334:
6126:
6054:
6017:
5984:"Location, location, location: the role of cyclin D1 nuclear localization in cancer"
5945:
5869:
5820:
5692:"Alternative cyclin D1 splice forms differentially regulate the DNA damage response"
5495:
5338:
5289:
5188:
5080:
5031:
4876:
4704:
4380:
4296:
4253:
4204:
3999:
3792:
3743:
3537:
2991:
2885:
2684:
2594:
2538:
2486:
2348:
2224:
2195:
2143:
1987:
6987:
5777:
5305:"Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD"
4979:
4617:
4363:
4346:
3580:
3103:
3042:
1944:
1635:
Inhibiting translation of cyclin D1 mRNA via mTOR inhibitors and RXR activators.
418:
197:
6254:"PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma"
6075:
5707:
4766:
4749:
4347:"Cotargeting cyclin D1 starts a new chapter in lung cancer prevention and therapy"
3389:
3372:
160:
4147:
4043:
Arnold A, Papanikolaou A (June 2005). "Cyclin D1 in breast cancer pathogenesis".
184:
7008:
6977:
4449:
1891:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1873:
National Center for
Biotechnology Information, U.S. National Library of Medicine
930:
positive regulation of cyclin-dependent protein serine/threonine kinase activity
6450:
Proceedings of the
National Academy of Sciences of the United States of America
6258:
Proceedings of the
National Academy of Sciences of the United States of America
5407:
Proceedings of the
National Academy of Sciences of the United States of America
5100:
Proceedings of the
National Academy of Sciences of the United States of America
4236:
4219:
3919:
3902:
3201:
2794:
Proceedings of the
National Academy of Sciences of the United States of America
1652:
Histone deacetylase inhibitors (HDACIs) to induce nuclear export of Cyclin D1
501:
6929:
6813:
6602:
6342:
Withers DA, Harvey RC, Faust JB, Melnyk O, Carey K, Meeker TC (October 1991).
6038:
5256:"Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors"
5045:
TaulΓ©s M, Rius E, Talaya D, LΓ³pez-Girona A, Bachs O, Agell N (December 1998).
4671:"A central domain of cyclin D1 mediates nuclear receptor corepressor activity"
4280:
3983:
3470:
2027:
Withers DA, Harvey RC, Faust JB, Melnyk O, Carey K, Meeker TC (October 1991).
1530:
1465:
317:
214:
164:
5171:
5154:
5063:
5046:
4644:
4323:
3520:
3503:
3209:
2617:
7052:
7002:
6992:
6675:
6671:
6661:
6657:
6643:
6639:
6629:
6625:
6470:
6407:
6278:
5929:
5427:
4750:"Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity"
4412:
4395:
4056:
2814:
1534:
1059:
561:
439:
384:
371:
283:
270:
172:
6547:
6510:
6359:
6305:
Xiong Y, Connolly T, Futcher B, Beach D (May 1991). "Human D-type cyclin".
6171:
6152:
6118:
6083:
6046:
6009:
5974:
5937:
5908:
Chung DC (April 2004). "Cyclin D1 in human neuroendocrine: tumorigenesis".
5900:
5852:
5835:
5769:
5760:
5743:
5742:
Siegert JL, Rushton JJ, Sellers WR, Kaelin WG, Robbins PD (November 2000).
5725:
5676:
5544:
5487:
5478:
5461:
5446:
5369:
5352:
Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (November 1998).
5330:
5321:
5304:
5281:
5272:
5255:
5139:
5120:
5023:
5014:
4997:
4928:
4910:
4868:
4859:
4842:
4827:
4775:
4731:
4696:
4687:
4670:
4652:
4609:
4574:
4457:
4421:
4372:
4331:
4288:
4245:
4196:
4187:
4170:
4155:
4120:
4092:
4064:
3991:
3956:
3928:
3775:
3758:
3735:
3700:
3665:
3629:
3572:
3488:
3439:
3398:
3315:
3266:
3227:
3157:
3138:
2877:
2868:
2851:
2833:
2774:
2730:
2721:
2704:
2676:
2667:
2650:
2635:
2530:
2398:
2340:
2331:
2314:
2299:
2281:
2250:
2187:
2178:
2161:
2135:
2044:
6555:
6518:
6489:
6436:
6415:
6377:
6326:
6297:
6244:
6222:
6200:
5861:
5812:
5626:
5585:
5526:
5387:
5237:
5219:
5180:
5072:
4971:
4539:
4498:
4026:
3887:
3846:
3819:
3784:
3727:
3529:
3356:
3095:
3034:
2983:
2934:
2586:
2478:
2442:
2417:"Cyclin D1 is a nuclear protein required for cell cycle progression in G1"
2241:
2097:
2062:
1979:
1936:
1369:
1364:
7057:
6997:
6982:
6951:
6937:
6667:
6649:
6635:
6621:
6444:
Tassan JP, Jaquenoud M, LΓ©opold P, Schultz SJ, Nigg EA (September 1995).
6109:
6092:
5617:
5600:
4895:"Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)"
4809:
3347:
3330:
2765:
2748:
2380:
1475:
Immunohistochemical staining of cyclin D1 antibodies is used to diagnose
1353:
1204:
1185:
33:
5155:"Identification of CDK4 sequences involved in cyclin D1 and p16 binding"
2916:
2433:
2416:
7066:
6973:
6946:
6605:
3297:
1752:
1728:
1692:
1385:
1171:
1126:
1015:
regulation of cyclin-dependent protein serine/threonine kinase activity
6571:
6000:
5983:
4794:"Cyclin D1 determines estrogen signaling in the mammary gland in vivo"
3086:
2577:
105:
101:
97:
93:
6905:
6821:
6807:
6803:
6799:
6791:
6749:
6744:
6613:
5560:"D-type cyclin-binding regions of proliferating cell nuclear antigen"
4963:
3077:
3026:
1928:
1337:
1081:
17:
4601:
3564:
2127:
2521:
2504:
1412:
Cyclin D1 is composed of the following protein domains and motifs:
658:
cyclin-dependent protein serine/threonine kinase regulator activity
6880:
6875:
6764:
6759:
6754:
1770:
1764:
1716:
1686:
1578:
induction of transcription by oncogenic Ras, Src, ErbB2 and STATs;
1460:
770:
positive regulation of mammary gland epithelial cell proliferation
4841:
Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (July 2000).
2612:. Cancer Treatment and Research. Vol. 119. pp. 217β37.
1044:
1040:
6909:
6900:
6870:
6849:
6787:
6134:
Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009).
1782:
1758:
1740:
1392:
152:
6575:
2415:
Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (May 1993).
6890:
6854:
6844:
6817:
6795:
3864:. Advances in Cancer Research. Vol. 68. pp. 67β108.
1566:
amplification of the CCND1 gene / overexpression of cyclin D1;
599:
2948:
Mittnacht S, Paterson H, Olson MF, Marshall CJ (March 1997).
3970:
Barnes DM, Gillett CE (1998). "Cyclin D1 in breast cancer".
2788:
McMahon C, Suthiphongchai T, DiRenzo J, Ewen ME (May 1999).
2747:
Fu M, Wang C, Li Z, Sakamaki T, Pestell RG (December 2004).
2162:"Cyclin D1: polymorphism, aberrant splicing and cancer risk"
1030:
positive regulation of G1/S transition of mitotic cell cycle
955:
positive regulation of G2/M transition of mitotic cell cycle
4512:
Obrig TG, Culp WJ, McKeehan WL, Hardesty B (January 1971).
3280:
Alt JR, Cleveland JL, Hannink M, Diehl JA (December 2000).
1559:
chemotherapeutic resistance and protection from apoptosis.
1454:
and the expression of this gene is regulated positively by
6091:
Li Z, Wang C, Prendergast GC, Pestell RG (November 2006).
2160:
Knudsen KE, Diehl JA, Haiman CA, Knudsen ES (March 2006).
1575:
disruption of nuclear export and proteolysis of cyclin D1;
3416:. Methods in Enzymology. Vol. 333. pp. 116β27.
830:
negative regulation of transcription by RNA polymerase II
683:
cyclin-dependent protein serine/threonine kinase activity
2266:"Cyclin D1 governs adhesion and motility of macrophages"
1425:
PEST sequence that may mark the protein for degradation;
995:
transcription initiation from RNA polymerase II promoter
408:
5303:
Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002).
2749:"Minireview: Cyclin D1: normal and abnormal functions"
2223:
He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (January 2014).
975:
negative regulation of epithelial cell differentiation
2365:"Cyclin D1 determines mitochondrial function in vivo"
1533:
upon phosphorylation of threonine 286 and subsequent
1520:
differentiation genes in the early to mid-G1 phase.
573:
3594:
Thomas GR, Nadiminti H, Regalado J (December 2005).
3178:"CRL4AMBRA1 is a master regulator of D-type cyclins"
1010:
positive regulation of epithelial cell proliferation
925:
positive regulation of cell population proliferation
7045:
7017:
6964:
6928:
6919:
6863:
6835:
6778:
6685:
6612:
5889:
Nihon Rinsho. Japanese
Journal of Clinical Medicine
5558:Matsuoka S, Yamaguchi M, Matsukage A (April 1994).
1294:
1273:
1243:
1222:
900:
regulation of G1/S transition of mitotic cell cycle
2698:
2696:
2694:
1847:
1845:
1843:
1826:
1824:
1822:
1486:. Its potential use as a biomarker was suggested.
714:cyclin-dependent protein kinase holoenzyme complex
3414:Regulators and Effectors of Small GTPases, Part G
1422:LxxLL binding motif for co-activator recruitment;
355:
254:
4471:Baliga BS, Pronczuk AW, Munro HN (August 1969).
3716:Journal of Cancer Research and Clinical Oncology
2899:BΓΆhmer RM, Scharf E, Assoian RK (January 1996).
1482:Cyclin D1 has been found to be overexpressed in
5737:
5735:
5249:
5247:
4991:
4989:
4888:
4886:
4787:
4785:
4743:
4741:
4664:
4662:
4171:"Chromosome translocations in multiple myeloma"
4136:Archives of Pathology & Laboratory Medicine
3600:International Journal of Experimental Pathology
1589:head and neck squamous cell carcinomas (30β50%)
890:endoplasmic reticulum unfolded protein response
2550:
2548:
1852:GRCm38: Ensembl release 89: ENSMUSG00000070348
780:positive regulation of protein phosphorylation
6587:
5834:Adnane J, Shao Z, Robbins PD (January 1999).
2155:
2153:
1902:
1900:
8:
6344:"Characterization of a candidate bcl-1 gene"
4038:
4036:
3247:
3245:
3171:
3169:
3167:
2029:"Characterization of a candidate bcl-1 gene"
1569:chromosomal translocation of the CCND1 gene;
810:negative regulation of Wnt signaling pathway
2610:Molecular Targeting and Signal Transduction
2109:
2107:
1831:GRCh38: Ensembl release 89: ENSG00000110092
1416:retinoblastoma protein (pRb) binding motif;
765:mammary gland epithelial cell proliferation
6925:
6594:
6580:
6572:
5910:Annals of the New York Academy of Sciences
3329:Diehl JA, Zindy F, Sherr CJ (April 1997).
2845:
2843:
1055:
910:mitotic G1 DNA damage checkpoint signaling
790:regulation of transcription, DNA-templated
615:
396:
295:
192:
139:, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
82:
6886:Cellular apoptosis susceptibility protein
6479:
6469:
6367:
6287:
6277:
6161:
6151:
6108:
5999:
5851:
5759:
5715:
5666:
5616:
5599:Xiong Y, Zhang H, Beach D (August 1993).
5575:
5534:
5477:
5436:
5426:
5377:
5320:
5271:
5227:
5170:
5129:
5119:
5062:
5013:
4918:
4858:
4817:
4765:
4686:
4529:
4488:
4411:
4362:
4235:
4186:
4169:Bergsagel PL, Kuehl WM (September 2001).
3918:
3774:
3619:
3519:
3478:
3388:
3346:
3305:
3217:
3147:
3137:
3085:
2973:
2924:
2867:
2823:
2813:
2764:
2720:
2666:
2576:
2520:
2432:
2410:
2408:
2388:
2330:
2289:
2240:
2177:
2052:
5254:Lin HM, Zhao L, Cheng SY (August 2002).
4996:Lin J, Jinno S, Okayama H (April 2001).
4400:Journal of the National Cancer Institute
4345:Kim ES, Lee JJ, Wistuba II (June 2011).
2498:
2496:
1620:
1404:cell lines (both lymphoid and myeloid).
885:cellular response to DNA damage stimulus
6093:"Cyclin D1 functions in cell migration"
3115:
3113:
1818:
5982:Gladden AB, Diehl JA (December 2005).
1025:regulation of mitotic nuclear division
760:cellular response to organic substance
37:
5967:10.1016/j.currproblcancer.2004.05.003
2742:
2740:
2008:. Weizmann Institute of Science. 2013
1649:Inducing nuclear export of Cyclin D1
1000:G1/S transition of mitotic cell cycle
360:
321:
316:
259:
218:
213:
7:
3972:Breast Cancer Research and Treatment
1586:non-small cell lung cancers (30β46%)
528:endothelial cell of lymphatic vessel
6140:The Journal of Biological Chemistry
5564:The Journal of Biological Chemistry
5466:The Journal of Biological Chemistry
5309:The Journal of Biological Chemistry
5260:The Journal of Biological Chemistry
5159:The Journal of Biological Chemistry
5051:The Journal of Biological Chemistry
4847:The Journal of Biological Chemistry
4518:The Journal of Biological Chemistry
4477:The Journal of Biological Chemistry
3508:The Journal of Biological Chemistry
2856:The Journal of Biological Chemistry
2655:The Journal of Biological Chemistry
2319:The Journal of Biological Chemistry
1005:cytokine-mediated signaling pathway
920:response to organonitrogen compound
795:response to organic cyclic compound
2505:"Cycling to cancer with cyclin D1"
1291:
1270:
1240:
1219:
1195:
1176:
1150:
1131:
1105:
1086:
840:mammary gland alveolus development
734:intracellular anatomical structure
688:protein-containing complex binding
638:transcription corepressor activity
578:
496:
434:
413:
25:
1388:that in humans is encoded by the
990:positive regulation of cell cycle
5988:Journal of Cellular Biochemistry
5659:10.1128/mcb.23.17.6159-6173.2003
4567:10.1097/00001813-200201000-00001
3612:10.1111/j.0959-9673.2005.00447.x
1640:Inducing Cyclin D1 degradation
825:re-entry into mitotic cell cycle
589:
582:
344:
337:
331:
308:
243:
236:
230:
205:
46:
6536:Genes, Chromosomes & Cancer
6499:International Journal of Cancer
1660:Small molecule CDK inhibitors
1657:Inhibition of cyclin D1-CDK4/6
935:canonical Wnt signaling pathway
729:transcription repressor complex
6348:Molecular and Cellular Biology
5647:Molecular and Cellular Biology
5208:Molecular and Cellular Biology
4590:Nature Reviews. Drug Discovery
4364:10.1158/1940-6207.CAPR-11-0143
2369:Molecular and Cellular Biology
2210:"Entrez Gene: CCND1 cyclin D1"
2033:Molecular and Cellular Biology
600:More reference expression data
562:More reference expression data
1:
6076:10.1016/j.lungcan.2006.09.024
6027:Cancer and Metastasis Reviews
5708:10.1158/0008-5472.CAN-10-0312
5577:10.1016/S0021-9258(19)78087-9
4767:10.1158/0008-5472.CAN-05-0486
4531:10.1016/S0021-9258(18)62546-3
4490:10.1016/S0021-9258(18)94343-7
3870:10.1016/s0065-230x(08)60352-8
3693:10.1016/s0169-5002(00)00160-4
3658:10.1016/s0169-5002(01)00225-2
3422:10.1016/s0076-6879(01)33050-1
3390:10.1158/0008-5472.CAN-06-1898
2975:10.1016/s0960-9822(97)70094-0
2905:Molecular Biology of the Cell
2569:10.1016/S0092-8674(00)81879-6
2270:Molecular Biology of the Cell
845:response to organic substance
329:
228:
7092:Genes on human chromosome 11
6319:10.1016/0092-8674(91)90100-D
6193:10.1016/0888-7543(92)90126-D
5805:10.1016/0092-8674(93)90137-f
4633:Journal of Clinical Oncology
4312:Journal of Clinical Oncology
4148:10.5858/2003-127-0424-COMCLC
4045:Journal of Clinical Oncology
2509:Cancer Biology & Therapy
2471:10.1016/0092-8674(92)90360-o
2090:10.1016/0888-7543(92)90126-d
1972:10.1016/0092-8674(91)90042-W
1671:Cyclin D1 has been shown to
1614:Therapeutic target in cancer
1598:pituitary adenomas (49β54%)
850:transcription, DNA-templated
643:transcription factor binding
6896:Maturation promoting factor
4450:10.1016/j.yexcr.2005.07.024
1592:pancreatic carcinomas (25%)
1468:of cyclin D1 staining in a
800:response to steroid hormone
785:Leydig cell differentiation
673:proline-rich region binding
648:histone deacetylase binding
450:stromal cell of endometrium
7108:
7037:Postreplication checkpoint
5955:Current Problems in Cancer
4438:Experimental Cell Research
4351:Cancer Prevention Research
4237:10.1182/blood-2003-11-3837
3202:10.1038/s41586-021-03445-y
2229:Molecular Medicine Reports
1545:ubiquitin ligase complex.
820:response to glucocorticoid
805:response to corticosterone
516:superior cervical ganglion
31:
6039:10.1007/s10555-005-5130-7
4281:10.1080/08977190500361812
4081:Molecular Cancer Research
3860:Hall M, Peters G (1996).
1887:"Mouse PubMed Reference:"
1869:"Human PubMed Reference:"
1524:Synthesis and degradation
1515:CDK independent functions
1368:
1363:
1359:
1352:
1336:
1330:Chr 7: 144.48 β 144.49 Mb
1317:
1298:
1277:
1266:
1247:
1226:
1215:
1202:
1198:
1183:
1179:
1170:
1157:
1153:
1138:
1134:
1125:
1112:
1108:
1093:
1089:
1080:
1065:
1058:
1054:
1038:
915:animal organ regeneration
815:response to magnesium ion
724:bicellular tight junction
618:
614:
597:
581:
572:
559:
508:
499:
462:mucosa of paranasal sinus
446:
437:
407:
399:
395:
378:
365:
328:
307:
298:
294:
277:
264:
227:
204:
195:
191:
146:
143:
133:
126:
121:
90:
85:
68:
63:
58:
54:
45:
40:
5887:Akita H (May 2002). "".
5172:10.1074/jbc.272.30.18869
5064:10.1074/jbc.273.50.33279
4645:10.1200/JCO.2005.03.7689
4324:10.1200/JCO.2005.01.9521
4109:Clinical Cancer Research
3945:Clinical Cancer Research
3920:10.1093/carcin/22.8.1149
3521:10.1074/jbc.270.40.23589
2618:10.1007/1-4020-7847-1_11
1632:Inhibition of cyclin D1
1323:Chr 11: 69.64 β 69.65 Mb
980:fat cell differentiation
860:regulation of cell cycle
6471:10.1073/pnas.92.19.8871
6408:10.1126/science.6610211
6279:10.1073/pnas.88.21.9638
5930:10.1196/annals.1294.022
5605:Genes & Development
5428:10.1073/pnas.0603363103
5358:Genes & Development
4899:Genes & Development
4798:Molecular Endocrinology
4057:10.1200/JCO.2005.05.064
3984:10.1023/a:1006103831990
3471:10.1093/emboj/18.5.1367
3335:Genes & Development
3286:Genes & Development
2815:10.1073/pnas.96.10.5382
2709:Molecular Endocrinology
2421:Genes & Development
1503:CDK dependent functions
1440:cyclin-dependent kinase
895:protein phosphorylation
875:response to calcium ion
633:protein kinase activity
27:Protein found in humans
7019:Cell cycle checkpoints
6548:10.1002/gcc.2870070205
6511:10.1002/ijc.2910620520
6360:10.1128/MCB.11.10.4846
6153:10.1074/jbc.M808843200
5853:10.1038/sj.onc.1202297
5761:10.1038/sj.onc.1203966
5479:10.1074/jbc.M503188200
5370:10.1101/gad.12.22.3488
5322:10.1074/jbc.M110747200
5273:10.1074/jbc.M203380200
5121:10.1073/pnas.160016897
5015:10.1038/sj.onc.1204375
4911:10.1101/gad.13.22.3027
4860:10.1074/jbc.M002598200
4688:10.1038/sj.onc.1208200
4188:10.1038/sj.onc.1204641
3776:10.1038/sj.onc.1202153
3553:Nature Reviews. Cancer
3139:10.1186/1476-4598-6-24
3120:Alao JP (April 2007).
2869:10.1074/jbc.M500403200
2722:10.1210/mend.15.5.0641
2668:10.1074/jbc.m500403200
2332:10.1074/jbc.M209354200
2282:10.1091/mbc.02-07-0102
2179:10.1038/sj.onc.1209371
2116:Nature Reviews. Cancer
2045:10.1128/MCB.11.10.4846
1627:Methods of Inhibition
1601:breast carcinoma (13%)
1554:Deregulation in cancer
1472:
678:protein kinase binding
7046:Other cellular phases
6770:CDK-activating kinase
5527:10.4161/cc.10.1.14243
5220:10.1128/MCB.17.9.5338
4413:10.1093/jnci/91.4.373
3728:10.1007/s004320100265
2242:10.3892/mmr.2013.1774
1549:Clinical significance
1464:
855:response to vitamin E
835:Wnt signaling pathway
775:response to estradiol
540:mandibular prominence
532:stroma of bone marrow
221:Chromosome 11 (human)
6110:10.4161/cc.5.21.3428
5618:10.1101/gad.7.8.1572
4810:10.1210/me.2013-1065
3348:10.1101/gad.11.8.957
2766:10.1210/en.2004-0959
2381:10.1128/MCB.02074-05
1808:Mantle cell lymphoma
1595:bladder cancer (15%)
1477:mantle cell lymphoma
1470:mantle cell lymphoma
870:response to estrogen
865:response to iron ion
362:7 F5|7 88.92 cM
323:Chromosome 7 (mouse)
86:List of PDB id codes
59:Available structures
6462:1995PNAS...92.8871T
6400:1984Sci...224.1403T
6270:1991PNAS...88.9638R
5922:2004NYASA1014..209C
5895:(Suppl 5): 267β71.
5419:2006PNAS..10311567W
5112:2000PNAS...97.9042C
4956:1993Natur.366..704S
3255:Anticancer Research
3194:2021Natur.592..789S
3070:1997Natur.386..177P
3019:1985Natur.313..241M
2966:1997CBio....7..219M
2917:10.1091/mbc.7.1.101
2806:1999PNAS...96.5382M
2434:10.1101/gad.7.5.812
1921:1991Natur.350..512M
1803:Parathyroid adenoma
965:response to ethanol
470:gingival epithelium
7032:Spindle checkpoint
6837:P53 p63 p73 family
3298:10.1101/gad.854900
1473:
1160:ENSMUSG00000070348
1020:mitotic cell cycle
970:response to leptin
905:liver regeneration
753:Biological process
697:Cellular component
626:Molecular function
7079:
7078:
7075:
7074:
7027:Restriction point
6001:10.1002/jcb.20613
4555:Anti-Cancer Drugs
3879:978-0-12-006668-1
3431:978-0-12-182234-7
3188:(7856): 789β793.
2627:978-1-4020-7822-4
2503:Diehl JA (2002).
1664:
1663:
1408:Protein structure
1379:
1378:
1375:
1374:
1348:
1347:
1313:
1312:
1288:
1287:
1262:
1261:
1237:
1236:
1211:
1210:
1192:
1191:
1166:
1165:
1147:
1146:
1121:
1120:
1102:
1101:
1050:
1049:
985:response to X-ray
950:liver development
610:
609:
606:
605:
568:
567:
555:
554:
493:
492:
391:
390:
290:
289:
185:CCND1 - orthologs
117:
116:
113:
112:
69:Ortholog search:
16:(Redirected from
7099:
6926:
6596:
6589:
6582:
6573:
6567:
6530:
6493:
6483:
6473:
6440:
6419:
6394:(4656): 1403β6.
6381:
6371:
6338:
6301:
6291:
6281:
6248:
6226:
6204:
6175:
6165:
6155:
6130:
6112:
6087:
6058:
6021:
6003:
5978:
5949:
5904:
5874:
5873:
5855:
5831:
5825:
5824:
5788:
5782:
5781:
5763:
5739:
5730:
5729:
5719:
5687:
5681:
5680:
5670:
5637:
5631:
5630:
5620:
5596:
5590:
5589:
5579:
5555:
5549:
5548:
5538:
5506:
5500:
5499:
5481:
5472:(33): 29728β42.
5457:
5451:
5450:
5440:
5430:
5413:(31): 11567β72.
5398:
5392:
5391:
5381:
5349:
5343:
5342:
5324:
5300:
5294:
5293:
5275:
5266:(32): 28733β41.
5251:
5242:
5241:
5231:
5199:
5193:
5192:
5174:
5165:(30): 18869β74.
5150:
5144:
5143:
5133:
5123:
5091:
5085:
5084:
5066:
5057:(50): 33279β86.
5042:
5036:
5035:
5017:
4993:
4984:
4983:
4964:10.1038/366704a0
4939:
4933:
4932:
4922:
4890:
4881:
4880:
4862:
4838:
4832:
4831:
4821:
4789:
4780:
4779:
4769:
4745:
4736:
4735:
4726:(10): 2297β301.
4715:
4709:
4708:
4690:
4666:
4657:
4656:
4628:
4622:
4621:
4585:
4579:
4578:
4550:
4544:
4543:
4533:
4509:
4503:
4502:
4492:
4468:
4462:
4461:
4432:
4426:
4425:
4415:
4391:
4385:
4384:
4366:
4342:
4336:
4335:
4307:
4301:
4300:
4264:
4258:
4257:
4239:
4215:
4209:
4208:
4190:
4166:
4160:
4159:
4131:
4125:
4124:
4103:
4097:
4096:
4075:
4069:
4068:
4040:
4031:
4030:
4010:
4004:
4003:
3967:
3961:
3960:
3939:
3933:
3932:
3922:
3898:
3892:
3891:
3857:
3851:
3850:
3830:
3824:
3823:
3803:
3797:
3796:
3778:
3754:
3748:
3747:
3711:
3705:
3704:
3676:
3670:
3669:
3640:
3634:
3633:
3623:
3591:
3585:
3584:
3548:
3542:
3541:
3523:
3514:(40): 23589β97.
3499:
3493:
3492:
3482:
3459:The EMBO Journal
3450:
3444:
3443:
3409:
3403:
3402:
3392:
3367:
3361:
3360:
3350:
3326:
3320:
3319:
3309:
3277:
3271:
3270:
3249:
3240:
3239:
3221:
3173:
3162:
3161:
3151:
3141:
3126:Molecular Cancer
3117:
3108:
3107:
3089:
3078:10.1038/386177a0
3064:(6621): 177β81.
3053:
3047:
3046:
3027:10.1038/313241a0
3002:
2996:
2995:
2977:
2945:
2939:
2938:
2928:
2896:
2890:
2889:
2871:
2862:(17): 16934β41.
2847:
2838:
2837:
2827:
2817:
2785:
2779:
2778:
2768:
2744:
2735:
2734:
2724:
2700:
2689:
2688:
2670:
2661:(17): 16934β41.
2646:
2640:
2639:
2605:
2599:
2598:
2580:
2552:
2543:
2542:
2524:
2500:
2491:
2490:
2453:
2447:
2446:
2436:
2412:
2403:
2402:
2392:
2359:
2353:
2352:
2334:
2325:(48): 45847β53.
2310:
2304:
2303:
2293:
2261:
2255:
2254:
2244:
2220:
2214:
2213:
2206:
2200:
2199:
2181:
2157:
2148:
2147:
2111:
2102:
2101:
2073:
2067:
2066:
2056:
2024:
2018:
2017:
2015:
2013:
1998:
1992:
1991:
1955:
1949:
1948:
1929:10.1038/350512a0
1904:
1895:
1894:
1883:
1877:
1876:
1865:
1859:
1849:
1838:
1828:
1621:
1529:degraded by the
1484:breast carcinoma
1361:
1360:
1332:
1325:
1308:
1292:
1283:
1271:
1267:RefSeq (protein)
1257:
1241:
1232:
1220:
1196:
1177:
1151:
1132:
1106:
1087:
1056:
940:response to UV-A
616:
602:
593:
586:
579:
564:
544:genital tubercle
520:seminal vesicula
504:
502:Top expressed in
497:
442:
440:Top expressed in
435:
414:
397:
387:
374:
363:
348:
341:
335:
324:
312:
296:
286:
273:
262:
247:
240:
234:
223:
209:
193:
187:
138:
131:
108:
83:
77:
56:
55:
50:
38:
21:
7107:
7106:
7102:
7101:
7100:
7098:
7097:
7096:
7082:
7081:
7080:
7071:
7061:
7041:
7013:
6960:
6955:
6941:
6921:
6915:
6859:
6831:
6774:
6681:
6608:
6600:
6570:
6533:
6496:
6443:
6422:
6384:
6354:(10): 4846β53.
6341:
6304:
6264:(21): 9638β42.
6251:
6229:
6207:
6178:
6133:
6090:
6061:
6024:
5981:
5952:
5907:
5886:
5882:
5880:Further reading
5877:
5833:
5832:
5828:
5790:
5789:
5785:
5754:(50): 5703β11.
5741:
5740:
5733:
5702:(21): 8802β11.
5696:Cancer Research
5689:
5688:
5684:
5653:(17): 6159β73.
5639:
5638:
5634:
5598:
5597:
5593:
5570:(15): 11030β6.
5557:
5556:
5552:
5508:
5507:
5503:
5459:
5458:
5454:
5400:
5399:
5395:
5364:(22): 3488β98.
5351:
5350:
5346:
5315:(11): 8847β53.
5302:
5301:
5297:
5253:
5252:
5245:
5201:
5200:
5196:
5152:
5151:
5147:
5093:
5092:
5088:
5044:
5043:
5039:
4995:
4994:
4987:
4950:(6456): 704β7.
4941:
4940:
4936:
4905:(22): 3027β33.
4892:
4891:
4884:
4853:(27): 20942β8.
4840:
4839:
4835:
4791:
4790:
4783:
4760:(15): 6557β67.
4754:Cancer Research
4747:
4746:
4739:
4720:Cancer Research
4717:
4716:
4712:
4668:
4667:
4660:
4639:(11): 1770β83.
4630:
4629:
4625:
4602:10.1038/nrd2907
4587:
4586:
4582:
4552:
4551:
4547:
4511:
4510:
4506:
4470:
4469:
4465:
4434:
4433:
4429:
4393:
4392:
4388:
4344:
4343:
4339:
4318:(34): 8757β64.
4309:
4308:
4304:
4266:
4265:
4261:
4217:
4216:
4212:
4181:(40): 5611β22.
4168:
4167:
4163:
4133:
4132:
4128:
4105:
4104:
4100:
4077:
4076:
4072:
4051:(18): 4215β24.
4042:
4041:
4034:
4012:
4011:
4007:
3969:
3968:
3964:
3941:
3940:
3936:
3900:
3899:
3895:
3880:
3859:
3858:
3854:
3835:Cancer Research
3832:
3831:
3827:
3808:Cancer Research
3805:
3804:
3800:
3769:(18): 2313β22.
3756:
3755:
3751:
3713:
3712:
3708:
3678:
3677:
3673:
3642:
3641:
3637:
3593:
3592:
3588:
3565:10.1038/nrc2230
3550:
3549:
3545:
3501:
3500:
3496:
3452:
3451:
3447:
3432:
3411:
3410:
3406:
3377:Cancer Research
3369:
3368:
3364:
3328:
3327:
3323:
3292:(24): 3102β14.
3279:
3278:
3274:
3251:
3250:
3243:
3175:
3174:
3165:
3119:
3118:
3111:
3055:
3054:
3050:
3013:(5999): 241β3.
3004:
3003:
2999:
2954:Current Biology
2947:
2946:
2942:
2898:
2897:
2893:
2849:
2848:
2841:
2787:
2786:
2782:
2759:(12): 5439β47.
2746:
2745:
2738:
2702:
2701:
2692:
2648:
2647:
2643:
2628:
2607:
2606:
2602:
2554:
2553:
2546:
2502:
2501:
2494:
2455:
2454:
2450:
2414:
2413:
2406:
2375:(14): 5449β69.
2361:
2360:
2356:
2312:
2311:
2307:
2263:
2262:
2258:
2222:
2221:
2217:
2208:
2207:
2203:
2159:
2158:
2151:
2128:10.1038/nrc3090
2113:
2112:
2105:
2075:
2074:
2070:
2039:(10): 4846β53.
2026:
2025:
2021:
2011:
2009:
2000:
1999:
1995:
1966:(6): 1197β206.
1957:
1956:
1952:
1915:(6318): 512β5.
1906:
1905:
1898:
1885:
1884:
1880:
1867:
1866:
1862:
1850:
1841:
1829:
1820:
1816:
1799:
1794:
1669:
1616:
1556:
1551:
1526:
1517:
1505:
1492:
1490:Normal function
1435:
1410:
1401:
1399:Gene expression
1370:View/Edit Mouse
1365:View/Edit Human
1328:
1321:
1318:Location (UCSC)
1304:
1300:
1279:
1253:
1249:
1228:
1141:ENSG00000110092
1034:
748:
692:
663:protein binding
653:kinase activity
598:
588:
587:
560:
551:
546:
542:
538:
534:
530:
526:
522:
518:
514:
500:
489:
486:skin of abdomen
484:
480:
476:
472:
468:
464:
460:
456:
452:
438:
382:
369:
361:
351:
350:
349:
342:
322:
299:Gene location (
281:
268:
260:
250:
249:
248:
241:
219:
196:Gene location (
147:
134:
127:
92:
70:
36:
28:
23:
22:
15:
12:
11:
5:
7105:
7103:
7095:
7094:
7084:
7083:
7077:
7076:
7073:
7072:
7070:
7069:
7064:
7059:
7055:
7049:
7047:
7043:
7042:
7040:
7039:
7034:
7029:
7023:
7021:
7015:
7014:
7012:
7011:
7006:
7000:
6995:
6990:
6985:
6980:
6970:
6968:
6962:
6961:
6959:
6958:
6953:
6949:
6944:
6939:
6934:
6932:
6923:
6917:
6916:
6914:
6913:
6903:
6898:
6893:
6888:
6883:
6878:
6873:
6867:
6865:
6861:
6860:
6858:
6857:
6852:
6847:
6841:
6839:
6833:
6832:
6830:
6829:
6811:
6784:
6782:
6776:
6775:
6773:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6691:
6689:
6683:
6682:
6680:
6679:
6665:
6647:
6633:
6618:
6616:
6610:
6609:
6601:
6599:
6598:
6591:
6584:
6576:
6569:
6568:
6531:
6494:
6456:(19): 8871β5.
6441:
6420:
6382:
6339:
6302:
6249:
6227:
6205:
6176:
6146:(9): 5574β81.
6131:
6103:(21): 2440β2.
6088:
6059:
6022:
5979:
5950:
5905:
5883:
5881:
5878:
5876:
5875:
5826:
5799:(3): 499β511.
5783:
5731:
5682:
5632:
5611:(8): 1572β83.
5591:
5550:
5501:
5452:
5393:
5344:
5295:
5243:
5214:(9): 5338β47.
5194:
5145:
5106:(16): 9042β6.
5086:
5037:
5008:(16): 2000β9.
4985:
4934:
4882:
4833:
4804:(9): 1415β28.
4781:
4737:
4710:
4658:
4623:
4580:
4545:
4504:
4483:(16): 4480β9.
4463:
4427:
4386:
4337:
4302:
4269:Growth Factors
4259:
4210:
4161:
4126:
4115:(8): 2069β76.
4098:
4070:
4032:
4015:Cancer Surveys
4005:
3962:
3934:
3913:(8): 1149β54.
3907:Carcinogenesis
3893:
3878:
3852:
3825:
3798:
3749:
3706:
3671:
3635:
3586:
3559:(10): 750β62.
3543:
3494:
3465:(5): 1367β77.
3445:
3430:
3404:
3383:(9): 4364β72.
3362:
3321:
3272:
3261:(2A): 639β47.
3241:
3163:
3109:
3048:
2997:
2940:
2911:(1): 101β111.
2891:
2839:
2800:(10): 5382β7.
2780:
2736:
2715:(5): 797β811.
2690:
2641:
2626:
2600:
2544:
2522:10.4161/cbt.72
2492:
2448:
2404:
2354:
2305:
2276:(5): 2005β15.
2256:
2215:
2201:
2172:(11): 1620β8.
2149:
2103:
2068:
2019:
2002:""CCND1" Gene"
1993:
1950:
1896:
1878:
1860:
1839:
1817:
1815:
1812:
1811:
1810:
1805:
1798:
1795:
1793:
1792:
1786:
1780:
1774:
1768:
1762:
1756:
1750:
1744:
1738:
1732:
1726:
1720:
1714:
1708:
1702:
1696:
1690:
1684:
1677:
1668:
1665:
1662:
1661:
1658:
1654:
1653:
1650:
1646:
1645:
1641:
1637:
1636:
1633:
1629:
1628:
1625:
1615:
1612:
1603:
1602:
1599:
1596:
1593:
1590:
1587:
1580:
1579:
1576:
1573:
1570:
1567:
1555:
1552:
1550:
1547:
1535:ubiquitylation
1525:
1522:
1516:
1513:
1504:
1501:
1497:Warburg effect
1491:
1488:
1434:
1431:
1430:
1429:
1426:
1423:
1420:
1417:
1409:
1406:
1400:
1397:
1377:
1376:
1373:
1372:
1367:
1357:
1356:
1350:
1349:
1346:
1345:
1343:
1341:
1334:
1333:
1326:
1319:
1315:
1314:
1311:
1310:
1296:
1295:
1289:
1286:
1285:
1275:
1274:
1268:
1264:
1263:
1260:
1259:
1245:
1244:
1238:
1235:
1234:
1224:
1223:
1217:
1213:
1212:
1209:
1208:
1200:
1199:
1193:
1190:
1189:
1181:
1180:
1174:
1168:
1167:
1164:
1163:
1155:
1154:
1148:
1145:
1144:
1136:
1135:
1129:
1123:
1122:
1119:
1118:
1110:
1109:
1103:
1100:
1099:
1091:
1090:
1084:
1078:
1077:
1072:
1067:
1063:
1062:
1052:
1051:
1048:
1047:
1036:
1035:
1033:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
756:
754:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
706:
700:
698:
694:
693:
691:
690:
685:
680:
675:
670:
668:enzyme binding
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
612:
611:
608:
607:
604:
603:
595:
594:
576:
570:
569:
566:
565:
557:
556:
553:
552:
550:
549:
545:
541:
537:
533:
529:
525:
524:tail of embryo
521:
517:
513:
509:
506:
505:
494:
491:
490:
488:
487:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
444:
443:
431:
430:
422:
411:
405:
404:
401:RNA expression
393:
392:
389:
388:
380:
376:
375:
367:
364:
359:
353:
352:
343:
336:
330:
326:
325:
320:
314:
313:
305:
304:
292:
291:
288:
287:
279:
275:
274:
266:
263:
258:
252:
251:
242:
235:
229:
225:
224:
217:
211:
210:
202:
201:
189:
188:
145:
141:
140:
132:
124:
123:
119:
118:
115:
114:
111:
110:
88:
87:
79:
78:
67:
61:
60:
52:
51:
43:
42:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7104:
7093:
7090:
7089:
7087:
7068:
7065:
7063:
7056:
7054:
7051:
7050:
7048:
7044:
7038:
7035:
7033:
7030:
7028:
7025:
7024:
7022:
7020:
7016:
7010:
7007:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6975:
6972:
6971:
6969:
6967:
6963:
6957:
6950:
6948:
6945:
6943:
6936:
6935:
6933:
6931:
6927:
6924:
6918:
6911:
6907:
6904:
6902:
6899:
6897:
6894:
6892:
6889:
6887:
6884:
6882:
6879:
6877:
6874:
6872:
6869:
6868:
6866:
6862:
6856:
6853:
6851:
6848:
6846:
6843:
6842:
6840:
6838:
6834:
6827:
6823:
6819:
6815:
6812:
6809:
6805:
6801:
6797:
6793:
6789:
6786:
6785:
6783:
6781:
6780:CDK inhibitor
6777:
6771:
6768:
6766:
6763:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6692:
6690:
6688:
6684:
6677:
6673:
6669:
6666:
6663:
6659:
6655:
6651:
6648:
6645:
6641:
6637:
6634:
6631:
6627:
6623:
6620:
6619:
6617:
6615:
6611:
6607:
6604:
6597:
6592:
6590:
6585:
6583:
6578:
6577:
6574:
6565:
6561:
6557:
6553:
6549:
6545:
6541:
6537:
6532:
6528:
6524:
6520:
6516:
6512:
6508:
6504:
6500:
6495:
6491:
6487:
6482:
6477:
6472:
6467:
6463:
6459:
6455:
6451:
6447:
6442:
6438:
6434:
6431:(8): 1581β8.
6430:
6426:
6421:
6417:
6413:
6409:
6405:
6401:
6397:
6393:
6389:
6383:
6379:
6375:
6370:
6365:
6361:
6357:
6353:
6349:
6345:
6340:
6336:
6332:
6328:
6324:
6320:
6316:
6312:
6308:
6303:
6299:
6295:
6290:
6285:
6280:
6275:
6271:
6267:
6263:
6259:
6255:
6250:
6246:
6242:
6239:(7): 1401β6.
6238:
6234:
6228:
6224:
6220:
6217:(2): 355β61.
6216:
6212:
6206:
6202:
6198:
6194:
6190:
6187:(3): 565β74.
6186:
6182:
6177:
6173:
6169:
6164:
6159:
6154:
6149:
6145:
6141:
6137:
6132:
6128:
6124:
6120:
6116:
6111:
6106:
6102:
6098:
6094:
6089:
6085:
6081:
6077:
6073:
6069:
6065:
6060:
6056:
6052:
6048:
6044:
6040:
6036:
6033:(3): 383β93.
6032:
6028:
6023:
6019:
6015:
6011:
6007:
6002:
5997:
5994:(5): 906β13.
5993:
5989:
5985:
5980:
5976:
5972:
5968:
5964:
5961:(5): 265β86.
5960:
5956:
5951:
5947:
5943:
5939:
5935:
5931:
5927:
5923:
5919:
5916:(1): 209β17.
5915:
5911:
5906:
5902:
5898:
5894:
5890:
5885:
5884:
5879:
5871:
5867:
5863:
5859:
5854:
5849:
5846:(1): 239β47.
5845:
5841:
5837:
5830:
5827:
5822:
5818:
5814:
5810:
5806:
5802:
5798:
5794:
5787:
5784:
5779:
5775:
5771:
5767:
5762:
5757:
5753:
5749:
5745:
5738:
5736:
5732:
5727:
5723:
5718:
5713:
5709:
5705:
5701:
5697:
5693:
5686:
5683:
5678:
5674:
5669:
5664:
5660:
5656:
5652:
5648:
5644:
5636:
5633:
5628:
5624:
5619:
5614:
5610:
5606:
5602:
5595:
5592:
5587:
5583:
5578:
5573:
5569:
5565:
5561:
5554:
5551:
5546:
5542:
5537:
5532:
5528:
5524:
5520:
5516:
5512:
5505:
5502:
5497:
5493:
5489:
5485:
5480:
5475:
5471:
5467:
5463:
5456:
5453:
5448:
5444:
5439:
5434:
5429:
5424:
5420:
5416:
5412:
5408:
5404:
5397:
5394:
5389:
5385:
5380:
5375:
5371:
5367:
5363:
5359:
5355:
5348:
5345:
5340:
5336:
5332:
5328:
5323:
5318:
5314:
5310:
5306:
5299:
5296:
5291:
5287:
5283:
5279:
5274:
5269:
5265:
5261:
5257:
5250:
5248:
5244:
5239:
5235:
5230:
5225:
5221:
5217:
5213:
5209:
5205:
5198:
5195:
5190:
5186:
5182:
5178:
5173:
5168:
5164:
5160:
5156:
5149:
5146:
5141:
5137:
5132:
5127:
5122:
5117:
5113:
5109:
5105:
5101:
5097:
5090:
5087:
5082:
5078:
5074:
5070:
5065:
5060:
5056:
5052:
5048:
5041:
5038:
5033:
5029:
5025:
5021:
5016:
5011:
5007:
5003:
4999:
4992:
4990:
4986:
4981:
4977:
4973:
4969:
4965:
4961:
4957:
4953:
4949:
4945:
4938:
4935:
4930:
4926:
4921:
4916:
4912:
4908:
4904:
4900:
4896:
4889:
4887:
4883:
4878:
4874:
4870:
4866:
4861:
4856:
4852:
4848:
4844:
4837:
4834:
4829:
4825:
4820:
4815:
4811:
4807:
4803:
4799:
4795:
4788:
4786:
4782:
4777:
4773:
4768:
4763:
4759:
4755:
4751:
4744:
4742:
4738:
4733:
4729:
4725:
4721:
4714:
4711:
4706:
4702:
4698:
4694:
4689:
4684:
4681:(3): 431β44.
4680:
4676:
4672:
4665:
4663:
4659:
4654:
4650:
4646:
4642:
4638:
4634:
4627:
4624:
4619:
4615:
4611:
4607:
4603:
4599:
4596:(7): 547β66.
4595:
4591:
4584:
4581:
4576:
4572:
4568:
4564:
4560:
4556:
4549:
4546:
4541:
4537:
4532:
4527:
4524:(1): 174β81.
4523:
4519:
4515:
4508:
4505:
4500:
4496:
4491:
4486:
4482:
4478:
4474:
4467:
4464:
4459:
4455:
4451:
4447:
4444:(2): 426β33.
4443:
4439:
4431:
4428:
4423:
4419:
4414:
4409:
4405:
4401:
4397:
4390:
4387:
4382:
4378:
4374:
4370:
4365:
4360:
4357:(6): 779β82.
4356:
4352:
4348:
4341:
4338:
4333:
4329:
4325:
4321:
4317:
4313:
4306:
4303:
4298:
4294:
4290:
4286:
4282:
4278:
4274:
4270:
4263:
4260:
4255:
4251:
4247:
4243:
4238:
4233:
4230:(4): 1120β6.
4229:
4225:
4221:
4214:
4211:
4206:
4202:
4198:
4194:
4189:
4184:
4180:
4176:
4172:
4165:
4162:
4157:
4153:
4149:
4145:
4142:(4): 424β31.
4141:
4137:
4130:
4127:
4122:
4118:
4114:
4110:
4102:
4099:
4094:
4090:
4087:(4): 300β11.
4086:
4082:
4074:
4071:
4066:
4062:
4058:
4054:
4050:
4046:
4039:
4037:
4033:
4028:
4024:
4020:
4016:
4009:
4006:
4001:
3997:
3993:
3989:
3985:
3981:
3978:(1β3): 1β15.
3977:
3973:
3966:
3963:
3958:
3954:
3951:(8): 2133β9.
3950:
3946:
3938:
3935:
3930:
3926:
3921:
3916:
3912:
3908:
3904:
3897:
3894:
3889:
3885:
3881:
3875:
3871:
3867:
3863:
3856:
3853:
3848:
3844:
3841:(9): 1634β7.
3840:
3836:
3829:
3826:
3821:
3817:
3814:(4): 949β56.
3813:
3809:
3802:
3799:
3794:
3790:
3786:
3782:
3777:
3772:
3768:
3764:
3760:
3753:
3750:
3745:
3741:
3737:
3733:
3729:
3725:
3721:
3717:
3710:
3707:
3702:
3698:
3694:
3690:
3686:
3682:
3675:
3672:
3667:
3663:
3659:
3655:
3652:(2): 207β18.
3651:
3647:
3639:
3636:
3631:
3627:
3622:
3617:
3613:
3609:
3606:(6): 347β63.
3605:
3601:
3597:
3590:
3587:
3582:
3578:
3574:
3570:
3566:
3562:
3558:
3554:
3547:
3544:
3539:
3535:
3531:
3527:
3522:
3517:
3513:
3509:
3505:
3498:
3495:
3490:
3486:
3481:
3476:
3472:
3468:
3464:
3460:
3456:
3449:
3446:
3441:
3437:
3433:
3427:
3423:
3419:
3415:
3408:
3405:
3400:
3396:
3391:
3386:
3382:
3378:
3374:
3366:
3363:
3358:
3354:
3349:
3344:
3341:(8): 957β72.
3340:
3336:
3332:
3325:
3322:
3317:
3313:
3308:
3303:
3299:
3295:
3291:
3287:
3283:
3276:
3273:
3268:
3264:
3260:
3256:
3248:
3246:
3242:
3237:
3233:
3229:
3225:
3220:
3215:
3211:
3207:
3203:
3199:
3195:
3191:
3187:
3183:
3179:
3172:
3170:
3168:
3164:
3159:
3155:
3150:
3145:
3140:
3135:
3131:
3127:
3123:
3116:
3114:
3110:
3105:
3101:
3097:
3093:
3088:
3083:
3079:
3075:
3071:
3067:
3063:
3059:
3052:
3049:
3044:
3040:
3036:
3032:
3028:
3024:
3020:
3016:
3012:
3008:
3001:
2998:
2993:
2989:
2985:
2981:
2976:
2971:
2967:
2963:
2960:(3): 219β21.
2959:
2955:
2951:
2944:
2941:
2936:
2932:
2927:
2922:
2918:
2914:
2910:
2906:
2902:
2895:
2892:
2887:
2883:
2879:
2875:
2870:
2865:
2861:
2857:
2853:
2846:
2844:
2840:
2835:
2831:
2826:
2821:
2816:
2811:
2807:
2803:
2799:
2795:
2791:
2784:
2781:
2776:
2772:
2767:
2762:
2758:
2754:
2753:Endocrinology
2750:
2743:
2741:
2737:
2732:
2728:
2723:
2718:
2714:
2710:
2706:
2699:
2697:
2695:
2691:
2686:
2682:
2678:
2674:
2669:
2664:
2660:
2656:
2652:
2645:
2642:
2637:
2633:
2629:
2623:
2619:
2615:
2611:
2604:
2601:
2596:
2592:
2588:
2584:
2579:
2574:
2570:
2566:
2563:(3): 405β15.
2562:
2558:
2551:
2549:
2545:
2540:
2536:
2532:
2528:
2523:
2518:
2515:(3): 226β31.
2514:
2510:
2506:
2499:
2497:
2493:
2488:
2484:
2480:
2476:
2472:
2468:
2465:(2): 323β34.
2464:
2460:
2452:
2449:
2444:
2440:
2435:
2430:
2427:(5): 812β21.
2426:
2422:
2418:
2411:
2409:
2405:
2400:
2396:
2391:
2386:
2382:
2378:
2374:
2370:
2366:
2358:
2355:
2350:
2346:
2342:
2338:
2333:
2328:
2324:
2320:
2316:
2309:
2306:
2301:
2297:
2292:
2287:
2283:
2279:
2275:
2271:
2267:
2260:
2257:
2252:
2248:
2243:
2238:
2235:(1): 137β43.
2234:
2230:
2226:
2219:
2216:
2211:
2205:
2202:
2197:
2193:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2156:
2154:
2150:
2145:
2141:
2137:
2133:
2129:
2125:
2122:(8): 558β72.
2121:
2117:
2110:
2108:
2104:
2099:
2095:
2091:
2087:
2084:(3): 565β74.
2083:
2079:
2072:
2069:
2064:
2060:
2055:
2050:
2046:
2042:
2038:
2034:
2030:
2023:
2020:
2007:
2003:
1997:
1994:
1989:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1954:
1951:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1903:
1901:
1897:
1892:
1888:
1882:
1879:
1874:
1870:
1864:
1861:
1857:
1853:
1848:
1846:
1844:
1840:
1836:
1832:
1827:
1825:
1823:
1819:
1813:
1809:
1806:
1804:
1801:
1800:
1796:
1790:
1787:
1784:
1781:
1778:
1775:
1772:
1769:
1766:
1763:
1760:
1757:
1754:
1751:
1748:
1745:
1742:
1739:
1736:
1733:
1730:
1727:
1724:
1721:
1718:
1715:
1712:
1709:
1706:
1703:
1700:
1697:
1694:
1691:
1688:
1685:
1682:
1679:
1678:
1676:
1674:
1666:
1659:
1656:
1655:
1651:
1648:
1647:
1642:
1639:
1638:
1634:
1631:
1630:
1626:
1623:
1622:
1619:
1613:
1611:
1607:
1600:
1597:
1594:
1591:
1588:
1585:
1584:
1583:
1577:
1574:
1571:
1568:
1565:
1564:
1563:
1560:
1553:
1548:
1546:
1544:
1540:
1536:
1532:
1523:
1521:
1514:
1512:
1509:
1502:
1500:
1498:
1489:
1487:
1485:
1480:
1478:
1471:
1467:
1463:
1459:
1457:
1453:
1449:
1445:
1441:
1432:
1427:
1424:
1421:
1418:
1415:
1414:
1413:
1407:
1405:
1398:
1396:
1394:
1391:
1387:
1383:
1371:
1366:
1362:
1358:
1355:
1351:
1344:
1342:
1339:
1335:
1331:
1327:
1324:
1320:
1316:
1309:
1307:
1303:
1297:
1293:
1290:
1284:
1282:
1276:
1272:
1269:
1265:
1258:
1256:
1252:
1246:
1242:
1239:
1233:
1231:
1225:
1221:
1218:
1216:RefSeq (mRNA)
1214:
1207:
1206:
1201:
1197:
1194:
1188:
1187:
1182:
1178:
1175:
1173:
1169:
1162:
1161:
1156:
1152:
1149:
1143:
1142:
1137:
1133:
1130:
1128:
1124:
1117:
1116:
1111:
1107:
1104:
1098:
1097:
1092:
1088:
1085:
1083:
1079:
1076:
1073:
1071:
1068:
1064:
1061:
1057:
1053:
1046:
1042:
1037:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
880:cell division
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
757:
755:
752:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
701:
699:
696:
695:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
621:
620:Gene ontology
617:
613:
601:
596:
592:
585:
580:
577:
575:
571:
563:
558:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
510:
507:
503:
498:
495:
485:
482:hair follicle
481:
477:
473:
469:
465:
461:
458:skin of thigh
457:
453:
449:
448:
445:
441:
436:
433:
432:
429:
427:
423:
421:
420:
416:
415:
412:
410:
406:
402:
398:
394:
386:
381:
377:
373:
368:
358:
354:
347:
340:
334:
327:
319:
315:
311:
306:
302:
297:
293:
285:
280:
276:
272:
267:
257:
253:
246:
239:
233:
226:
222:
216:
212:
208:
203:
199:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
142:
137:
130:
125:
120:
109:
107:
103:
99:
95:
89:
84:
81:
80:
76:
73:
66:
62:
57:
53:
49:
44:
39:
35:
30:
19:
6988:Prometaphase
6653:
6542:(2): 89β95.
6539:
6535:
6505:(5): 610β8.
6502:
6498:
6453:
6449:
6428:
6424:
6391:
6387:
6351:
6347:
6313:(4): 691β9.
6310:
6306:
6261:
6257:
6236:
6232:
6214:
6210:
6184:
6180:
6143:
6139:
6100:
6096:
6067:
6063:
6030:
6026:
5991:
5987:
5958:
5954:
5913:
5909:
5892:
5888:
5843:
5839:
5829:
5796:
5792:
5786:
5751:
5747:
5699:
5695:
5685:
5650:
5646:
5635:
5608:
5604:
5594:
5567:
5563:
5553:
5521:(1): 73β81.
5518:
5514:
5504:
5469:
5465:
5455:
5410:
5406:
5396:
5361:
5357:
5347:
5312:
5308:
5298:
5263:
5259:
5211:
5207:
5197:
5162:
5158:
5148:
5103:
5099:
5089:
5054:
5050:
5040:
5005:
5001:
4947:
4943:
4937:
4902:
4898:
4850:
4846:
4836:
4801:
4797:
4757:
4753:
4723:
4719:
4713:
4678:
4674:
4636:
4632:
4626:
4593:
4589:
4583:
4558:
4554:
4548:
4521:
4517:
4507:
4480:
4476:
4466:
4441:
4437:
4430:
4406:(4): 373β9.
4403:
4399:
4389:
4354:
4350:
4340:
4315:
4311:
4305:
4272:
4268:
4262:
4227:
4223:
4213:
4178:
4174:
4164:
4139:
4135:
4129:
4112:
4108:
4101:
4084:
4080:
4073:
4048:
4044:
4018:
4014:
4008:
3975:
3971:
3965:
3948:
3944:
3937:
3910:
3906:
3896:
3861:
3855:
3838:
3834:
3828:
3811:
3807:
3801:
3766:
3762:
3752:
3722:(9): 531β6.
3719:
3715:
3709:
3684:
3680:
3674:
3649:
3645:
3638:
3603:
3599:
3589:
3556:
3552:
3546:
3511:
3507:
3497:
3462:
3458:
3448:
3413:
3407:
3380:
3376:
3365:
3338:
3334:
3324:
3289:
3285:
3275:
3258:
3254:
3185:
3181:
3129:
3125:
3061:
3057:
3051:
3010:
3006:
3000:
2957:
2953:
2943:
2908:
2904:
2894:
2859:
2855:
2797:
2793:
2783:
2756:
2752:
2712:
2708:
2658:
2654:
2644:
2609:
2603:
2560:
2556:
2512:
2508:
2462:
2458:
2451:
2424:
2420:
2372:
2368:
2357:
2322:
2318:
2308:
2273:
2269:
2259:
2232:
2228:
2218:
2204:
2169:
2165:
2119:
2115:
2081:
2077:
2071:
2036:
2032:
2022:
2010:. Retrieved
2005:
1996:
1963:
1959:
1953:
1912:
1908:
1890:
1881:
1872:
1863:
1670:
1667:Interactions
1617:
1608:
1604:
1581:
1561:
1557:
1527:
1518:
1510:
1506:
1493:
1481:
1474:
1436:
1411:
1402:
1389:
1381:
1380:
1306:NP_001366177
1299:
1278:
1255:NM_001379248
1248:
1227:
1203:
1184:
1158:
1139:
1113:
1094:
1074:
1069:
536:otic vesicle
424:
417:
383:144,493,662
370:144,483,668
144:External IDs
91:
29:
7009:Cytokinesis
6978:Preprophase
6922:checkpoints
6070:(1): 1β14.
6064:Lung Cancer
4561:(1): 1β13.
4275:(1): 13β9.
3681:Lung Cancer
3646:Lung Cancer
2653:. primary.
739:nucleoplasm
548:human fetus
466:sural nerve
454:skin of arm
282:69,654,474
269:69,641,156
122:Identifiers
6930:Interphase
6920:Phases and
6603:Cell cycle
6097:Cell Cycle
5515:Cell Cycle
3687:(1): 3β8.
3087:1874/15252
2578:1874/21074
1858:, May 2017
1837:, May 2017
1814:References
1610:myelomas.
1531:proteasome
1466:Micrograph
945:cell cycle
428:(ortholog)
165:HomoloGene
32:See also:
7053:Apoptosis
7003:Telophase
6993:Metaphase
6788:INK4a/ARF
4021:: 77β94.
3236:233243768
3210:0028-0836
2006:GeneCards
1382:Cyclin D1
1302:NP_031657
1281:NP_444284
1251:NM_007631
1230:NM_053056
1060:Orthologs
960:lactation
704:cytoplasm
173:GeneCards
7086:Category
6998:Anaphase
6983:Prophase
6606:proteins
6564:32254958
6527:23260113
6425:Oncogene
6335:33443183
6233:Oncogene
6211:Oncogene
6181:Genomics
6172:19124461
6127:22220763
6119:17106256
6084:17070615
6055:25369592
6047:16258726
6018:35774178
6010:16163738
5975:15375804
5946:35976233
5938:15153436
5901:12101670
5870:38863669
5840:Oncogene
5821:24708871
5770:11126356
5748:Oncogene
5726:20940395
5677:12917338
5545:21200149
5496:23571294
5488:15951563
5447:16864783
5339:42467757
5331:11788592
5290:30676926
5282:12048199
5189:37191598
5140:10908655
5081:36068143
5032:25204152
5024:11360184
5002:Oncogene
4929:10580009
4877:20433975
4869:10801854
4828:23864650
4776:16061635
4732:10344732
4705:21812009
4697:15558026
4675:Oncogene
4653:16603719
4610:19568282
4575:11914636
4458:16153639
4422:10050872
4381:12781005
4373:21636543
4332:16314636
4297:21082281
4289:16393691
4254:24192626
4246:15090460
4205:19937243
4197:11607813
4175:Oncogene
4156:12683869
4121:10473088
4093:12612058
4065:15961768
4000:31241216
3992:10066068
3957:10473097
3929:11470742
3793:17852339
3763:Oncogene
3744:24010774
3736:11570573
3701:11162860
3666:11679179
3630:16309541
3573:17891190
3538:20805160
3489:10064602
3440:11400329
3399:17483350
3316:11124803
3267:12014632
3228:33854235
3158:17407548
2992:12508796
2886:27249858
2878:15713663
2834:10318892
2775:15331580
2731:11328859
2685:27249858
2677:15713663
2636:15164880
2595:16492666
2539:27507264
2531:12432268
2487:19669023
2399:16809779
2349:27287405
2341:12235165
2300:12802071
2251:24190141
2196:11382318
2188:16550162
2166:Oncogene
2144:29093377
2136:21734724
2078:Genomics
1988:12166415
1854:–
1833:–
1797:See also
1673:interact
1541:-AMBRA1
1537:via the
1433:Function
1354:Wikidata
1039:Sources:
719:membrane
512:calvaria
34:Cyclin D
7067:Meiosis
6974:Mitosis
6966:M phase
6947:S phase
6814:cip/kip
6556:7687458
6519:7665234
6490:7568034
6458:Bibcode
6437:7478582
6416:6610211
6396:Bibcode
6388:Science
6378:1833629
6327:1827756
6298:1682919
6266:Bibcode
6245:1535701
6223:1532244
6201:1386335
6163:2645817
5918:Bibcode
5862:9926939
5813:8490963
5778:1413527
5717:2970762
5627:8101826
5586:7908906
5536:3048077
5438:1518800
5415:Bibcode
5388:9832502
5238:9271411
5181:9228064
5108:Bibcode
5073:9837900
4980:4368128
4972:8259215
4952:Bibcode
4819:3753428
4618:7417169
4540:5541758
4499:5806588
4027:8013002
3888:8712071
3847:9134998
3820:7850812
3785:9811462
3621:2517451
3581:8244897
3530:7559524
3480:1171226
3357:9136925
3219:8875297
3190:Bibcode
3149:1851974
3104:4354374
3096:9062190
3066:Bibcode
3043:4322964
3035:3918269
3015:Bibcode
2984:9395436
2962:Bibcode
2935:8741843
2802:Bibcode
2587:9039267
2479:1423597
2443:8491378
2390:1592725
2098:1386335
2063:1833629
1980:1833066
1945:4232393
1937:1826542
1917:Bibcode
1856:Ensembl
1835:Ensembl
1753:PACSIN2
1729:NEUROD1
1693:CCNDBP1
1624:Target
1386:protein
1172:UniProt
1127:Ensembl
1066:Species
1045:QuickGO
744:nucleus
709:cytosol
403:pattern
261:11q13.3
129:Aliases
6906:Cullin
6792:p14arf
6614:Cyclin
6562:
6554:
6525:
6517:
6488:
6478:
6435:
6414:
6376:
6369:361453
6366:
6333:
6325:
6296:
6286:
6243:
6221:
6199:
6170:
6160:
6125:
6117:
6082:
6053:
6045:
6016:
6008:
5973:
5944:
5936:
5899:
5868:
5860:
5819:
5811:
5776:
5768:
5724:
5714:
5675:
5668:180960
5665:
5625:
5584:
5543:
5533:
5494:
5486:
5445:
5435:
5386:
5379:317237
5376:
5337:
5329:
5288:
5280:
5236:
5229:232384
5226:
5187:
5179:
5138:
5128:
5079:
5071:
5030:
5022:
4978:
4970:
4944:Nature
4927:
4920:317153
4917:
4875:
4867:
4826:
4816:
4774:
4730:
4703:
4695:
4651:
4616:
4608:
4573:
4538:
4497:
4456:
4420:
4379:
4371:
4330:
4295:
4287:
4252:
4244:
4203:
4195:
4154:
4119:
4091:
4063:
4025:
3998:
3990:
3955:
3927:
3886:
3876:
3845:
3818:
3791:
3783:
3742:
3734:
3699:
3664:
3628:
3618:
3579:
3571:
3536:
3528:
3487:
3477:
3438:
3428:
3397:
3355:
3314:
3307:317128
3304:
3265:
3234:
3226:
3216:
3208:
3182:Nature
3156:
3146:
3132:: 24.
3102:
3094:
3058:Nature
3041:
3033:
3007:Nature
2990:
2982:
2933:
2926:278616
2923:
2884:
2876:
2832:
2822:
2773:
2729:
2683:
2675:
2634:
2624:
2593:
2585:
2537:
2529:
2485:
2477:
2441:
2397:
2387:
2347:
2339:
2298:
2291:165093
2288:
2249:
2194:
2186:
2142:
2134:
2096:
2061:
2054:361453
2051:
2012:May 6,
1986:
1978:
1943:
1935:
1909:Nature
1785:, and
1675:with:
1340:search
1338:PubMed
1205:P25322
1186:P24385
1082:Entrez
574:BioGPS
474:nipple
153:168461
7062:phase
6956:phase
6942:phase
6881:Cdc42
6876:Cdc25
6864:Other
6646:, B3)
6560:S2CID
6523:S2CID
6481:41069
6331:S2CID
6289:52773
6123:S2CID
6051:S2CID
6014:S2CID
5942:S2CID
5866:S2CID
5817:S2CID
5774:S2CID
5492:S2CID
5335:S2CID
5286:S2CID
5185:S2CID
5131:16818
5077:S2CID
5028:S2CID
4976:S2CID
4873:S2CID
4701:S2CID
4614:S2CID
4377:S2CID
4293:S2CID
4250:S2CID
4224:Blood
4201:S2CID
3996:S2CID
3789:S2CID
3740:S2CID
3577:S2CID
3534:S2CID
3232:S2CID
3100:S2CID
3039:S2CID
2988:S2CID
2882:S2CID
2825:21868
2681:S2CID
2591:S2CID
2535:S2CID
2483:S2CID
2345:S2CID
2192:S2CID
2140:S2CID
1984:S2CID
1941:S2CID
1789:NR1A2
1771:RAD51
1765:PPARG
1735:NCOA1
1723:HDACs
1717:HDAC3
1687:BRCA1
1681:NR3C4
1390:CCND1
1384:is a
1115:12443
1075:Mouse
1070:Human
1041:Amigo
478:tibia
426:Mouse
419:Human
366:Start
301:Mouse
265:Start
198:Human
177:CCND1
161:88313
136:CCND1
41:CCND1
18:CCND1
6910:CUL7
6871:Cdc2
6552:PMID
6515:PMID
6486:PMID
6433:PMID
6412:PMID
6374:PMID
6323:PMID
6307:Cell
6294:PMID
6241:PMID
6219:PMID
6197:PMID
6168:PMID
6115:PMID
6080:PMID
6043:PMID
6006:PMID
5971:PMID
5934:PMID
5914:1014
5897:PMID
5858:PMID
5809:PMID
5793:Cell
5766:PMID
5722:PMID
5673:PMID
5623:PMID
5582:PMID
5541:PMID
5484:PMID
5443:PMID
5384:PMID
5327:PMID
5278:PMID
5234:PMID
5177:PMID
5136:PMID
5069:PMID
5020:PMID
4968:PMID
4925:PMID
4865:PMID
4824:PMID
4772:PMID
4728:PMID
4693:PMID
4649:PMID
4606:PMID
4571:PMID
4536:PMID
4495:PMID
4454:PMID
4418:PMID
4369:PMID
4328:PMID
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