994:, out of which, the most abundant are the T cells specific for CD1c. Three models of CD1 recognition by TCR have been described: “head group recognition” model, “absence of interference” model and “altered CD1” model. The “head group recognition” model is considered to be a classical mode of CD1-antigen recognition, whereas the other two are only “emerging” CD1-antigen recognition models which predict that TCR contacts CD1 and not lipid.
1014:
TCR which bound the CD1a without contacting the lipid that CD1a was carrying. In accordance to the left-right asymmetry of CD1, the small hydrophobic lipid ligand emerges from the F’ binding pocket (the right side of the CD1 binding cleft) and TCR binds to the A’ binding pocket (the left side of
998:
The “Head group recognition” model, also called “headgroup discrimination” model, is attributed to CD1b and CD1d, and it refers to the fact that TCR do not only react to peptidic antigens, but can also recognise and bind to the structure of
868:
is an intermediate form, a soluble lipid transfer protein that is expressed intracellularly. It does not present lipid antigens to T cells, rather plays a role in the processing of lipid antigens and loading them onto other CD1 molecules.
970:
Human CD1 cells can recognise and bind a large number of lipids, from monoacylated lipids or lipopeptides to tetra-acylated lipids. However, not all of the lipid ligands can be considered antigens for T-cells. Free fatty acids
827:
which differ in their lipid anchoring, as well as their expression patterns of the CD1 genes (CD1d is constitutively expressed, whereas the group 1 CD1 genes are inducible and coordinately regulated by
2687:
1275:
Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (October 1989). "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes".
912:. Natural Killer T (NKT) cells are activated by CD1d-presented antigens, and rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.
1826:
803:. Genes of the CD1 family were first cloned in 1986, by Franco Calabi and C. Milstein, whereas the first known lipid antigen for CD1 was discovered in 1994, during studies of
962:. Another difference between MHC and CD1 proteins is that the antigen display platform of CD1 molecules is smaller than the antigen display groove of MHC molecules.
958:
The main difference in structure between MHC and CD1 proteins is that in MHC proteins, the contact region for TCR show lateral symmetry, whereas human CD1 proteins show
923:
CD1 proteins consist of a heavy chain with α1, α2, and α3 domains and a transmembrane domain which anchors it to the cell membrane. Much like the MHC molecules, the CD1
1026:
The “altered CD1” model is attributed to CD1c. CD1c has A’ pole, F’ roof and G’ portal, which serve as points of access to the binding cleft. When it is loaded with
2677:
633:
492:
351:
206:
61:
2657:
885:
molecules have been shown to present foreign lipid antigens, and specifically a number of mycobacterial cell wall components, to CD1-specific T cells.
3519:
1843:
1819:
3250:
1097:
lack the group 2 CD1 molecules, and have an expanded set of group 1 CD1 molecules. Because of this and the fact that cows are a natural host of
3238:
3016:
1764:
3302:
3297:
3243:
3023:
1804:
1403:
3856:
3851:
2756:
2682:
1812:
1023:
can be considered antagonists for CD1 autoreactive cells, as they have a large polar head group and can block the CD1a A’ binding pocket.
851:
CD1e is also considered a group 1 CD1 molecule, even though it does not function in antigen presentation, contrasting the other isoforms.
3785:
3780:
3775:
3770:
2697:
657:
516:
375:
230:
85:
3750:
1695:
1101:, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system.
915:
The group 2 (CD1d) ligand α-GalCer is currently in phase I clinical trials for the treatment of advanced non-hematologic cancers.
2986:
645:
504:
363:
218:
73:
3554:
3048:
2734:
3193:
2729:
638:
497:
356:
211:
66:
3690:
3162:
3157:
3102:
2836:
2285:
1060:
3384:
3107:
1124:
Layre E, de Jong A, Moody DB (December 2014). "Human T cells use CD1 and MR1 to recognize lipids and small molecules".
935:, placed atop a β-sheet platform. The antigen-binding cleft architecture of CD1 proteins consists of A’, C’, F’ and T’
2702:
3414:
1839:
924:
804:
753:
2280:
3464:
2359:
1758:
1006:
The “absence of interference” model emerged as a result of the identification of tissue-derived CD1a-presented
894:
761:
3428:
2771:
2766:
2761:
2751:
2058:
1986:
1469:
650:
509:
368:
223:
78:
2115:
2033:
991:
955:
antigens. CD1 antigen binding clefts are defined by locations of named portals where antigens protrude.
905:
1165:
3352:
3065:
1284:
1048:
959:
928:
815:
offers the prospect of discovering new approaches to therapy and developing immunomodulatory agents.
703:
562:
421:
276:
131:
807:. The first antigen that was discovered to be able to bind CD1 and then be recognised by TCR is C80
3379:
3198:
1769:
1098:
1011:
2786:
2520:
1579:
Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (December 2000).
1308:
1201:
940:
793:
781:
811:. Even though their precise function is unknown, The CD1 system of lipid antigen recognition by
1055:
and malignancies arising from T cell precursors. CD1a, in particular, is a specific marker for
1734:
1691:
1668:
1650:
1602:
1561:
1543:
1497:
1489:
1450:
1409:
1399:
1368:
1300:
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1193:
1185:
1141:
1064:
1047:
cells from these populations, so that the presence of CD1 antigens can be used in diagnostic
3559:
3292:
3213:
2776:
1969:
1895:
1724:
1658:
1642:
1592:
1551:
1535:
1481:
1440:
1391:
1358:
1348:
1292:
1247:
1239:
1177:
1133:
1086:. Thus, mice have been used extensively to characterize the role of CD1d and CD1d-dependent
893:
The natural antigens of group 2 CD1 are not well characterized, but a synthetic glycolipid,
698:
557:
416:
271:
126:
3619:
2155:
2150:
2073:
1711:
Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, et al. (April 2006).
1485:
1056:
841:
824:
812:
789:
727:
586:
445:
300:
155:
707:
566:
425:
280:
135:
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1363:
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1252:
1227:
1164:
Tang Y, Ma S, Lin S, Wu Y, Chen S, Liu G, Ma L, Wang Z, Jiang L, Wang Y (2023-03-01).
3845:
3374:
2831:
1922:
1581:"Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells"
1205:
1083:
1020:
898:
857:
757:
1797:
1792:
1787:
1782:
1777:
1030:
and lipids, CD1c alters its 3D surface in order to act as a TCR recognition surface.
3730:
3038:
3028:
2559:
2525:
1353:
1312:
1007:
1000:
972:
948:
808:
800:
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1428:
674:
533:
392:
247:
102:
3740:
3389:
3167:
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2841:
2463:
2389:
1863:
1729:
1712:
1395:
1390:. Current Topics in Microbiology and Immunology. Vol. 314. pp. 27–50.
952:
936:
932:
882:
845:
769:
765:
737:
596:
455:
310:
165:
22:
1137:
3670:
3394:
3075:
2816:
2692:
2325:
2320:
2315:
2170:
1954:
1646:
1539:
1429:"The role of group 1 and group 2 CD1-restricted T cells in microbial immunity"
1181:
1166:"Cell-free protein synthesis of CD1E and B2M protein and in vitro interaction"
1027:
980:
976:
944:
777:
681:
540:
399:
254:
109:
1713:"The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d"
1654:
1547:
1493:
1189:
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3499:
3489:
3484:
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3474:
1040:
1016:
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1672:
1606:
1597:
1580:
1565:
1501:
1454:
1413:
1372:
1261:
1197:
1145:
1524:"The CD1 family: serving lipid antigens to T cells since the Mesozoic era"
1304:
3815:
3715:
3529:
3514:
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2712:
2620:
2310:
1087:
1068:
1044:
686:
545:
404:
259:
114:
983:
small molecules and some oils function as natural antigens for T cells.
848:
molecules) are expressed on cells specialized for antigen presentation.
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1052:
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and other non-peptidic head groups of antigens that are carried by CD1.
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2135:
2098:
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2011:
2006:
1296:
823:
CD1 glycoproteins can be classified primarily into two groups of CD1
785:
669:
528:
387:
242:
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2212:
2187:
2165:
2160:
2053:
1979:
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987:
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773:
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and C’ and D’/E’ accessory portals, which act to accommodate the
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2018:
2001:
1996:
1991:
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611:
521:
485:
470:
380:
235:
90:
46:
31:
1808:
1637:. Antigen processing * Special section: Metabolism of T cells.
3337:
1949:
1937:
1932:
1927:
1917:
1890:
1226:
Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB (October 2015).
1386:
Zajonc DM, Wilson IA (2007). "Architecture of CD1 Proteins".
1082:
lack the group 1 CD1 molecules, and instead have 2 copies of
904:
Group 2 CD1 molecules activate a group of T cells, known as
897:(α-GalCer), originally isolated from a compound found in a
908:
because of their expression of NK surface markers such as
1063:. Other conditions that may show CD1 positivity include
1043:, but not on mature T cells. This often remains true in
861:(group 2 CD1) is expressed in a wider variety of cells.
1631:"Four pathways of CD1 antigen presentation to T cells"
1059:, and can therefore also be used in the diagnosis of
764:. CD1 glycoproteins are structurally related to the
931:
and its binding groove consists of two antiparallel
3643:
3437:
3186:
2870:
2593:
2253:
1851:
1690:. London: Greenwich Medical Media. pp. 59–60.
1688:
Manual of diagnostic antibodies for immunohistology
1470:"The Immunology of CD1- and MR1-Restricted T Cells"
1010:and the first CD1a-lipid-TCR structure, between an
733:
723:
718:
697:
692:
680:
668:
656:
644:
632:
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161:
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125:
120:
108:
96:
84:
72:
60:
52:
42:
37:
30:
1228:"Lipid and small-molecule display by CD1 and MR1"
1221:
1219:
1217:
1215:
1624:
1622:
1620:
1618:
1616:
1820:
1517:
1515:
1513:
1511:
8:
1468:Mori L, Lepore M, De Libero G (2016-05-20).
1330:
1328:
1326:
1324:
1322:
1119:
1117:
1115:
1113:
1388:T Cell Activation by CD1 and Lipid Antigens
1159:
1157:
1155:
1827:
1813:
1805:
1774:The Human Protein Atlas - Additional Info
760:expressed on the surface of various human
715:
574:
433:
288:
143:
1844:list of human clusters of differentiation
1757:at the U.S. National Library of Medicine
1728:
1662:
1596:
1555:
1444:
1362:
1352:
1251:
799:The human CD1 gene cluster is located on
780:and small molecules antigens, from both
21:For the album by Throbbing Gristle, see
1109:
1039:CD1 antigens are expressed on cortical
788:and activate an immune response. Both
607:
466:
321:
176:
27:
1486:10.1146/annurev-immunol-032414-112008
986:10% of all αβ T lymphocytes in human
7:
1686:Kumarasen C, Anthony S-Y L (2003).
1585:The Journal of Biological Chemistry
1170:Protein Expression and Purification
1126:Current Opinion in Chemical Biology
768:molecules, however, in contrast to
1629:Moody DB, Cotton RN (2017-06-01).
1335:Moody DB, Suliman S (2017-10-30).
14:
1337:"CD1: From Molecules to Diseases"
1427:Sköld M, Behar SM (March 2005).
1093:It has recently been shown that
1090:in a variety of disease models.
901:, has strong biologic activity.
1354:10.12688/f1000research.12178.1
1:
1635:Current Opinion in Immunology
1061:Langerhans cell histiocytosis
1446:10.1016/j.micinf.2004.12.012
784:and pathogenic proteins, to
3857:Clusters of differentiation
3852:Genes on human chromosome 1
1840:clusters of differentiation
1730:10.4049/jimmunol.176.8.4888
1474:Annual Review of Immunology
1396:10.1007/978-3-540-69511-0_2
3873:
1232:Nature Reviews. Immunology
1138:10.1016/j.cbpa.2014.09.007
966:CD1-lipid TCR interactions
805:Mycobacterium tuberculosis
754:cluster of differentiation
20:
1647:10.1016/j.coi.2017.07.013
1540:10.1007/s00251-016-0931-0
1522:Zajonc DM (August 2016).
1182:10.1016/j.pep.2022.106209
943:chains present in lipid,
796:recognise CD1 molecules.
714:
573:
432:
287:
142:
1759:Medical Subject Headings
1128:. Molecular immunology.
895:alpha-galactosylceramide
762:antigen-presenting cells
18:Family of glycoproteins
1770:Human CD Antigen Chart
1765:Mouse CD Antigen Chart
1598:10.1074/jbc.M007082200
1433:Microbes and Infection
992:CD1-restricted T cells
906:Natural killer T cells
1717:Journal of Immunology
979:, lysophospholipids,
941:aliphatic hydrocarbon
1049:immunohistochemistry
1035:Diagnostic relevance
960:left-right asymmetry
770:MHC class 1 proteins
1591:(48): 37757–37764.
1289:1989Natur.341..447P
1099:Mycobacterium bovis
756:1) is a family of
3839:
3838:
1405:978-3-540-69510-3
1283:(6241): 447–450.
1065:myeloid leukaemia
1051:to identify some
975:, phospholipids,
747:
746:
743:
742:
606:
605:
602:
601:
465:
464:
461:
460:
320:
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175:
174:
171:
170:
3864:
1829:
1822:
1815:
1806:
1743:
1742:
1732:
1723:(8): 4888–4893.
1708:
1702:
1701:
1683:
1677:
1676:
1666:
1626:
1611:
1610:
1600:
1576:
1570:
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1505:
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1297:10.1038/341447a0
1272:
1266:
1265:
1255:
1223:
1210:
1209:
1161:
1150:
1149:
1121:
1075:In cows and mice
1067:and some B cell
1057:Langerhans cells
988:peripheral blood
929:β2-microglobulin
927:associates with
716:
608:
575:
467:
434:
322:
289:
177:
144:
28:
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1384:
1380:
1334:
1333:
1320:
1274:
1273:
1269:
1244:10.1038/nri3889
1238:(10): 643–654.
1225:
1224:
1213:
1163:
1162:
1153:
1123:
1122:
1111:
1107:
1077:
1037:
968:
937:binding pockets
921:
891:
880:
875:
821:
772:, they present
26:
19:
12:
11:
5:
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1528:Immunogenetics
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1021:sphingomyelin
1018:
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984:
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974:
973:sphingolipids
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899:marine sponge
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830:myeloid cells
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758:glycoproteins
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612:CD1e molecule
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414:
409:
406:
403:
401:
397:
394:
391:
389:
385:
382:
379:
377:
373:
370:
367:
365:
361:
358:
355:
353:
349:
345:
341:
337:
333:
328:
325:CD1c molecule
323:
312:
309:
305:
302:
299:
295:
290:
286:
283:
282:
278:
275:
273:
269:
264:
261:
258:
256:
252:
249:
246:
244:
240:
237:
234:
232:
228:
225:
222:
220:
216:
213:
210:
208:
204:
200:
196:
192:
188:
183:
180:CD1b molecule
178:
167:
164:
160:
157:
154:
150:
145:
141:
138:
137:
133:
130:
128:
124:
119:
116:
113:
111:
107:
104:
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
68:
65:
63:
59:
55:
51:
48:
45:
41:
36:
33:
32:CD1a molecule
29:
24:
16:
3357:
3277:
3255:
3233:
3080:
3043:
3006:
2959:
2929:
2902:
2724:
2630:
2478:
2207:
1959:
1858:
1720:
1716:
1706:
1687:
1681:
1638:
1634:
1588:
1584:
1574:
1531:
1527:
1477:
1473:
1463:
1436:
1432:
1422:
1387:
1381:
1344:
1340:
1280:
1276:
1270:
1235:
1231:
1173:
1169:
1129:
1125:
1092:
1078:
1038:
1012:autoreactive
1008:autoantigens
1001:carbohydrate
985:
969:
957:
949:phospholipid
922:
914:
903:
892:
881:
864:
856:
822:
809:mycolic acid
801:chromosome 1
798:
749:
748:
706:
565:
424:
343:Alt. symbols
279:
198:Alt. symbols
134:
53:Alt. symbols
15:
1755:CD1+Antigen
1641:: 127–133.
1028:fatty acids
981:amphipathic
977:sulfolipids
953:lipopeptide
925:heavy chain
883:Group 1 CD1
846:group 1 CD1
778:glycolipids
766:class I MHC
728:Swiss-model
618:Identifiers
587:Swiss-model
477:Identifiers
446:Swiss-model
330:Identifiers
301:Swiss-model
185:Identifiers
156:Swiss-model
38:Identifiers
23:CD1 (album)
3846:Categories
1842:(see also
1176:: 106209.
1105:References
1045:neoplastic
1041:thymocytes
945:glycolipid
794:γδ T cells
782:endogenous
724:Structures
719:Search for
693:Other data
583:Structures
578:Search for
552:Other data
442:Structures
437:Search for
411:Other data
297:Structures
292:Search for
266:Other data
152:Structures
147:Search for
121:Other data
1655:0952-7915
1548:0093-7711
1494:0732-0582
1206:254180046
1190:1046-5928
1132:: 31–38.
1088:NKT cells
1069:lymphomas
1017:Sulfatide
933:α-helices
919:Structure
873:In humans
675:NM_030893
634:NCBI gene
534:NM_001766
493:NCBI gene
393:NM_001765
352:NCBI gene
248:NM_001764
207:NCBI gene
103:NM_001763
62:NCBI gene
1836:Proteins
1739:16585584
1673:28756303
1607:10948205
1566:27368414
1502:26927205
1455:15777730
1414:17593656
1373:29152228
1347:: 1909.
1262:26388332
1198:36460227
1146:25271021
1053:thymomas
825:isoforms
738:InterPro
597:InterPro
456:InterPro
311:InterPro
166:InterPro
3644:301–350
3438:251–300
3390:CD240CE
3187:201–250
2871:151–200
2594:101–150
1664:5599164
1557:5087154
1364:5664979
1313:4264602
1305:2477705
1285:Bibcode
1253:6944187
1015:CD1a).
889:Group 2
878:Group 1
786:T cells
734:Domains
708:q22-q23
682:UniProt
593:Domains
567:q22-q23
541:UniProt
452:Domains
426:q22-q23
400:UniProt
307:Domains
281:q22-q23
255:UniProt
162:Domains
136:q22-q23
110:UniProt
3651:CD300A
3610:CDw293
3395:CD240D
3256:CD213a
3234:CDw210
3199:CD202b
3173:CDw199
3168:CDw198
2822:CD140b
2254:51–100
1761:(MeSH)
1737:
1694:
1671:
1661:
1653:
1605:
1564:
1554:
1546:
1500:
1492:
1453:
1412:
1402:
1371:
1361:
1311:
1303:
1277:Nature
1260:
1250:
1204:
1196:
1188:
1144:
836:CD1a,
774:lipids
704:Chr. 1
687:P15812
670:RefSeq
663:188411
623:Symbol
563:Chr. 1
546:P15813
529:RefSeq
522:188410
482:Symbol
422:Chr. 1
405:P29017
388:RefSeq
381:188340
335:Symbol
277:Chr. 1
260:P29016
243:RefSeq
236:188360
190:Symbol
132:Chr. 1
115:P06126
98:RefSeq
91:188370
43:Symbol
3831:CD350
3826:CD349
3821:CD344
3816:CD340
3811:CD339
3806:CD338
3801:CD337
3796:CD336
3791:CD335
3786:CD334
3781:CD333
3776:CD332
3771:CD331
3766:CD329
3761:CD328
3756:CD327
3751:CD326
3746:CD325
3741:CD324
3736:CD322
3731:CD321
3726:CD320
3721:CD318
3716:CD317
3711:CD316
3706:CD315
3701:CD314
3696:CD312
3691:CD309
3686:CD307
3681:CD306
3676:CD305
3671:CD304
3666:CD303
3661:CD302
3656:CD301
3635:CD299
3630:CD298
3625:CD297
3620:CD295
3615:CD294
3605:CD292
3600:CD290
3595:CD289
3590:CD288
3585:CD286
3580:CD284
3575:CD283
3570:CD282
3565:CD281
3560:CD280
3555:CD279
3550:CD278
3545:CD276
3540:CD275
3535:CD274
3530:CD273
3525:CD272
3520:CD271
3515:CD269
3510:CD268
3505:CD267
3500:CD266
3495:CD265
3490:CD264
3485:CD263
3480:CD262
3475:CD261
3470:CD258
3465:CD257
3460:CD256
3455:CD254
3450:CD253
3445:CD252
3429:CD249
3424:CD248
3420:CD247
3415:CD246
3410:CD244
3405:CD243
3400:CD241
3385:CD239
3380:CD238
3375:CD236
3358:CD235
3353:CD234
3348:CD233
3343:CD230
3338:CD229
3333:CD228
3328:CD227
3323:CD226
3318:CD225
3313:CD224
3308:CD223
3303:CD222
3298:CD221
3293:CD220
3278:CD218
3273:CD217
3251:CD212
3229:CD209
3224:CD208
3219:CD207
3214:CD206
3209:CD205
3204:CD204
3194:CD201
3178:CD200
3163:CD197
3158:CD196
3153:CD195
3148:CD194
3143:CD193
3138:CD192
3133:CD191
3128:CD186
3123:CD185
3118:CD184
3113:CD183
3108:CD182
3103:CD181
3098:CD180
3081:CD179
3076:CD178
3071:CD177
3066:CD174
3044:CD172
3039:CD171
3034:CD170
3029:CD169
3024:CD168
3007:CD167
3002:CD166
2997:CD164
2992:CD163
2987:CD162
2982:CD161
2977:CD160
2960:CD159
2930:CD158
2925:CD157
2903:CD156
2898:CD155
2893:CD154
2888:CD153
2883:CD152
2878:CD151
2862:CD150
2857:CD148
2852:CD147
2847:CD146
2842:CD144
2837:CD143
2832:CD142
2827:CD141
2817:CD138
2812:CD137
2807:CD136
2802:CD135
2797:CD134
2792:CD133
2787:CD132
2782:CD131
2777:CD130
2772:CD129
2767:CD127
2762:CD126
2757:CD125
2752:CD124
2747:CD123
2742:CD122
2725:CD121
2708:CD120
2703:CD119
2698:CD118
2693:CD117
2688:CD116
2683:CD115
2678:CD114
2673:CD113
2668:CD112
2663:CD111
2658:CD110
2653:CD109
2648:CD108
2631:CD107
2626:CD106
2621:CD105
2616:CD104
2611:CD103
2606:CD102
2601:CD101
2585:CD100
1309:S2CID
1202:S2CID
951:, or
910:CD161
819:Types
699:Locus
558:Locus
417:Locus
272:Locus
127:Locus
2580:CD99
2575:CD98
2570:CD97
2565:CD96
2560:CD95
2555:CD94
2550:CD93
2545:CD92
2541:CD91
2536:CD90
2531:CD89
2526:CD88
2521:CD87
2516:CD86
2479:CD85
2474:CD84
2469:CD83
2464:CD82
2459:CD81
2454:CD80
2437:CD79
2432:CD78
2427:CD74
2422:CD73
2417:CD72
2412:CD71
2407:CD70
2402:CD69
2397:CD68
2360:CD66
2338:CD64
2333:CD63
2311:CD62
2306:CD61
2301:CD59
2296:CD58
2291:CD57
2286:CD56
2281:CD55
2276:CD54
2271:CD53
2266:CD52
2261:CD51
2245:CD50
2208:CD49
2203:CD48
2198:CD47
2193:CD46
2188:CD45
2183:CD44
2178:CD43
2151:CD42
2146:CD41
2141:CD40
2136:CD39
2131:CD38
2126:CD37
2121:CD36
2116:CD35
2111:CD34
2106:CD33
2089:CD32
2084:CD31
2079:CD30
2074:CD29
2069:CD28
2064:CD27
2059:CD26
2054:CD25
2049:CD24
2044:CD23
2039:CD22
2034:CD21
2029:CD20
2024:CD19
2019:CD18
2002:CD16
1997:CD15
1992:CD14
1987:CD13
1960:CD11
1955:CD10
1852:1–50
1798:CD1e
1793:CD1d
1788:CD1c
1783:CD1b
1778:CD1a
1735:PMID
1692:ISBN
1669:PMID
1651:ISSN
1603:PMID
1562:PMID
1544:ISSN
1498:PMID
1490:ISSN
1451:PMID
1410:PMID
1400:ISBN
1369:PMID
1301:PMID
1258:PMID
1194:PMID
1186:ISSN
1142:PMID
1095:cows
1084:CD1d
1080:Mice
1019:and
990:are
866:CD1e
858:CD1d
842:CD1c
840:and
838:CD1b
792:and
658:OMIM
651:1638
646:HGNC
627:CD1E
517:OMIM
510:1637
505:HGNC
486:CD1D
376:OMIM
369:1636
364:HGNC
338:CD1C
231:OMIM
224:1635
219:HGNC
193:CD1B
86:OMIM
79:1634
74:HGNC
47:CD1A
1950:CD9
1938:CD8
1933:CD7
1928:CD6
1923:CD5
1918:CD4
1896:CD3
1891:CD2
1864:a-c
1859:CD1
1725:doi
1721:176
1659:PMC
1643:doi
1593:doi
1589:275
1552:PMC
1536:doi
1482:doi
1441:doi
1392:doi
1359:PMC
1349:doi
1293:doi
1281:341
1248:PMC
1240:doi
1178:doi
1174:203
1134:doi
832:).
813:TCR
750:CD1
639:913
498:912
357:911
346:CD1
212:910
201:CD1
67:909
56:CD1
3848::
3422:-
2543:-
1884:1E
1879:1D
1874:1B
1869:1A
1838::
1733:.
1719:.
1715:.
1667:.
1657:.
1649:.
1639:46
1633:.
1615:^
1601:.
1587:.
1583:.
1560:.
1550:.
1542:.
1532:68
1530:.
1526:.
1510:^
1496:.
1488:.
1478:34
1476:.
1472:.
1449:.
1435:.
1431:.
1408:.
1398:.
1367:.
1357:.
1343:.
1339:.
1321:^
1307:.
1299:.
1291:.
1279:.
1256:.
1246:.
1236:15
1234:.
1230:.
1214:^
1200:.
1192:.
1184:.
1172:.
1168:.
1154:^
1140:.
1130:23
1112:^
1071:.
947:,
790:αβ
776:,
3368:b
3363:a
3289:)
3287:b
3282:a
3280:(
3266:2
3261:1
3244:b
3239:a
3091:b
3086:a
3059:g
3054:b
3049:a
3017:b
3012:a
2970:c
2965:a
2956:)
2954:k
2949:i
2944:e
2939:d
2934:a
2932:(
2918:c
2913:b
2908:a
2735:b
2730:a
2718:b
2713:a
2641:b
2636:a
2509:k
2504:j
2499:h
2494:e
2489:d
2484:a
2447:b
2442:a
2390:f
2385:e
2380:d
2375:c
2370:b
2365:a
2353:C
2348:B
2343:A
2326:P
2321:L
2316:E
2238:f
2233:e
2228:d
2223:c
2218:b
2213:a
2171:d
2166:c
2161:b
2156:a
2099:B
2094:A
2012:B
2007:A
1980:d
1975:c
1970:b
1965:a
1943:a
1911:ε
1906:δ
1901:Îł
1846:)
1828:e
1821:t
1814:v
1741:.
1727::
1700:.
1675:.
1645::
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1595::
1568:.
1538::
1504:.
1484::
1457:.
1443::
1437:7
1416:.
1394::
1375:.
1351::
1345:6
1315:.
1295::
1287::
1264:.
1242::
1208:.
1180::
1148:.
1136::
844:(
752:(
25:.
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