184:
209:
417:
29:
215:
1101:(OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40-Ig can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
55:
1021:
production. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response due to its ability to enhance survival. OX40 also plays a crucial role in both
1210:
1005:
cells for the first three days, however after this time proliferation begins to slow and cells die at a greater rate, due to an inability to maintain a high level of PKB activity and expression of
4912:
4271:
2505:
4696:
1059:
is down-regulated following OX40 engagement in vivo and the OX40-specific TRAF3 DN defect was partially overcome by CTLA-4 blockade in vivo. TRAF3 may be linked to OX40-mediated
1644:
1336:"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB"
222:
989:, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without
1449:
Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M (February 2004). "The costimulation-regulated duration of PKB activation controls T cell longevity".
4928:
5390:
1214:
4856:
4394:
2495:
4978:
5410:
3681:
1295:"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation"
1063:
expansion and survival, and point to the down-regulation of CTLA-4 as a possible control element to enhance early T cell expansion through OX40 signaling.
5038:
4689:
2475:
695:
676:
145:
4071:
3337:
1661:
1637:
1051:
seems to have a more negative or modulatory role, as knockouts have higher levels of cytokines and are more susceptible to Th2-mediated inflammation.
5381:
5370:
5346:
4836:
4642:
4360:
4356:
4339:
3068:
4725:
4473:
4448:
4312:
3056:
2834:
4872:
4682:
4477:
4452:
4303:
3120:
3115:
3061:
2841:
1622:
1192:
1174:
5777:
5767:
5004:
4630:
4329:
4264:
2574:
2500:
1630:
1104:
An anti-OX40 antibody GSK3174998 has started clinical trials as a cancer treatment. Research in mice has included the combination of an
4324:
3603:
3598:
3593:
3588:
2515:
1387:
4736:
5690:
3568:
893:
4203:
3908:
3900:
3674:
2804:
4551:
3849:
3372:
2866:
2552:
1161:
5401:
5103:
4546:
4494:
3885:
3011:
2547:
1393:
208:
183:
116:, ACT35, CD134, IMD16, OX40, TXGP1L, tumor necrosis factor receptor superfamily member 4, TNF receptor superfamily member 4
52:
3798:
3760:
3755:
3508:
2980:
2975:
2920:
2654:
2103:
1157:
5705:
3803:
3202:
2925:
125:
221:
4515:
4511:
3667:
2520:
1125:
4216:
214:
5695:
5337:
4531:
4147:
3703:
3232:
1657:
5296:
4766:
4507:
4431:
4130:
3916:
2098:
4661:
4625:
4156:
3282:
2177:
133:
5049:
4745:
4580:
4558:
4482:
4469:
4456:
4444:
4412:
4399:
4389:
4365:
4352:
4308:
4299:
4226:
4199:
4190:
3785:
3246:
721:
4761:
5434:
4617:
4541:
4294:
4260:
4251:
4221:
4212:
4195:
3793:
3713:
2589:
2584:
2579:
2569:
1876:
1804:
5246:
5241:
5192:
4319:
1933:
1851:
1521:
Croft M (August 2003). "Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?".
982:
4831:
4846:
5361:
5197:
4902:
4796:
4439:
4347:
4289:
4246:
4173:
3170:
2883:
197:
112:
5604:
5312:
5202:
5094:
4811:
4806:
4801:
4791:
4656:
4651:
4489:
3197:
3016:
1399:
1109:
1017:. OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing
5065:
4923:
4892:
1560:"OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells"
5226:
5221:
5187:
5182:
5128:
4943:
4716:
4708:
4646:
4417:
4165:
3698:
2604:
2338:
1546:
1474:
157:
5715:
5019:
5009:
4999:
4933:
4882:
876:
855:
829:
808:
416:
5644:
5634:
5624:
5561:
5286:
4989:
5654:
5639:
5556:
5521:
5266:
4771:
4705:
3690:
1610:
1581:
1538:
1509:
1488:"Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion"
1466:
1437:
1365:
1316:
1275:
1257:
1108:
OX40 antibody (clone OX86) injected directly into a tumor in combination with an unmethylated
978:
105:
45:
5581:
4756:
1606:
153:
5772:
5307:
5236:
5231:
5119:
4776:
4605:
4408:
4281:
4122:
4114:
4015:
4007:
3999:
3991:
3377:
3110:
3031:
2594:
1787:
1713:
1602:
1571:
1530:
1499:
1458:
1427:
1355:
1347:
1306:
1265:
1249:
301:
232:
5215:
5685:
5662:
5207:
5124:
4887:
4031:
3437:
1973:
1968:
1891:
1211:"GSK and Merck to study immunotherapy combination as potential cancer treatment. Nov 2015"
1082:
276:
28:
5546:
5536:
5463:
5080:
5070:
4994:
4826:
3932:
3222:
2644:
2155:
1958:
1270:
1237:
1098:
1094:
1075:
1576:
1559:
1360:
1335:
1043:, 3 and 5 as well as PI3K by an unknown mechanism. TRAF2 is required for survival via
610:
605:
600:
595:
590:
585:
580:
575:
570:
565:
560:
555:
550:
545:
540:
535:
530:
525:
509:
504:
499:
494:
489:
484:
468:
463:
458:
5761:
5114:
4897:
4816:
4384:
4178:
3192:
2649:
1740:
1060:
445:
1550:
1478:
1236:
Sagiv-Barfi I, Czerwinski DK, Levy S, Alam IS, Mayer AT, Gambhir SS, Levy R (2018).
5720:
5700:
5619:
5609:
5551:
5498:
5428:
5327:
5271:
4958:
4948:
4938:
4841:
4821:
4786:
4781:
4572:
3940:
3548:
2856:
2846:
2377:
2343:
294:
174:
137:
1593:
Watts TH (2005). "TNF/TNFR family members in costimulation of T cell responses".
1504:
1487:
1253:
969:-superfamily of receptors which is not constitutively expressed on resting naïve
161:
5730:
5725:
5629:
5614:
5586:
5576:
5571:
5526:
5493:
5488:
5483:
5478:
5473:
5458:
5453:
5276:
5261:
5256:
5075:
5060:
4877:
3765:
3740:
3558:
3207:
2985:
2960:
2659:
2281:
2207:
1681:
1432:
1415:
1197:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1179:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4674:
1416:"TNF receptor-associated factor 5 limits the induction of Th2 immune responses"
5566:
5468:
5322:
4867:
3488:
3212:
2893:
2634:
2510:
2143:
2138:
2133:
1988:
1772:
1072:
191:
141:
1261:
5740:
5735:
5516:
4963:
4055:
4047:
4039:
3327:
3322:
3317:
3307:
3302:
3297:
3292:
1311:
1294:
1105:
640:
394:
315:
260:
247:
149:
1614:
1585:
1542:
1513:
1470:
1441:
1279:
1369:
1320:
938:
933:
4968:
4095:
4087:
4079:
4063:
3633:
3533:
3347:
3332:
2535:
2530:
2438:
2128:
1351:
1044:
1023:
1018:
1014:
922:
783:
764:
4464:
4460:
4207:
3583:
3578:
3573:
3473:
3287:
3277:
3104:
3083:
3078:
3046:
2851:
2771:
2766:
2761:
2756:
2751:
2669:
2362:
2202:
2197:
2192:
2187:
2182:
1653:
1293:
Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (March 1998).
1032:
970:
750:
707:
82:
78:
74:
5541:
5531:
5176:
5172:
5168:
5164:
5160:
5156:
4600:
4595:
4590:
4585:
4562:
4502:
4498:
4238:
3871:
3659:
3523:
3483:
3468:
3452:
3447:
3427:
3422:
3357:
3165:
3135:
3099:
3090:
2903:
2871:
2735:
2730:
2700:
2679:
2639:
2599:
2465:
2443:
2402:
2326:
2321:
2316:
2311:
2306:
2301:
2170:
2165:
2160:
2108:
2093:
1963:
1953:
1916:
1911:
1829:
1824:
1558:
Rogers PR, Song J, Gramaglia I, Killeen N, Croft M (September 2001).
1056:
1010:
906:
662:
1534:
1462:
1002:
981:
molecule, expressed after 24 to 72 hours following activation; its
5211:
5152:
5148:
5144:
5140:
5136:
5132:
5029:
4635:
4255:
4186:
4182:
3972:
3866:
3830:
3825:
3820:
3815:
3810:
3775:
3735:
3725:
3648:
3623:
3543:
3538:
3528:
3518:
3503:
3498:
3493:
3478:
3432:
3417:
3382:
3367:
3362:
3352:
3272:
3267:
3262:
3241:
3237:
3227:
3140:
3041:
3036:
2995:
2945:
2940:
2935:
2930:
2915:
2908:
2888:
2876:
2819:
2814:
2809:
2799:
2794:
2787:
2725:
2715:
2710:
2705:
2695:
2674:
2664:
2629:
2624:
2619:
2609:
2564:
2559:
2525:
2490:
2485:
2480:
2470:
2458:
2453:
2433:
2428:
2423:
2418:
2372:
2264:
2259:
2078:
2062:
2055:
2050:
2045:
2040:
2035:
2030:
2005:
1983:
1978:
1871:
1797:
1792:
1782:
1133:
1129:
1052:
1048:
1040:
1006:
986:
1414:
So T, Salek-Ardakani S, Nakano H, Ware CF, Croft M (April 2004).
625:
621:
5596:
5508:
5445:
4023:
3964:
3956:
3948:
3859:
3770:
3750:
3745:
3730:
3721:
3643:
3638:
3628:
3618:
3613:
3608:
3563:
3553:
3513:
3442:
3412:
3407:
3402:
3397:
3392:
3387:
3342:
3312:
3217:
3185:
3180:
3160:
3150:
3145:
3130:
3125:
3026:
3021:
2990:
2970:
2965:
2955:
2950:
2829:
2782:
2742:
2397:
2392:
2387:
2382:
2367:
2358:
2353:
2348:
2333:
2291:
2286:
2276:
2271:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2214:
2150:
2123:
2118:
2113:
2088:
2083:
2020:
2015:
2010:
2000:
1995:
1948:
1943:
1938:
1928:
1923:
1906:
1901:
1896:
1886:
1881:
1866:
1861:
1856:
1846:
1841:
1836:
1819:
1814:
1809:
1760:
1728:
1723:
1718:
1701:
1696:
1691:
1686:
1116:
ligand activates expression of OX40 so that it can be affected.
1113:
1079:
990:
974:
966:
536:
negative regulation of DNA-binding transcription factor activity
129:
4678:
3663:
1626:
1055:
may play a critical role in OX40-mediated signal transduction.
606:
negative regulation of activation-induced cell death of T cells
425:
3155:
1767:
1755:
1750:
1745:
1735:
1708:
1676:
1238:"Eradication of spontaneous malignancy by local immunotherapy"
1027:
993:, expression of OX40 is delayed and of fourfold lower levels.
611:
negative regulation of extrinsic apoptotic signaling pathway
1078:
associated with certain viral infections, including the
284:
4837:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
1001:
OX40 has no effect on the proliferative abilities of
406:
951:
Tumor necrosis factor receptor superfamily, member 4
5675:
5653:
5595:
5507:
5444:
5427:
5420:
5400:
5380:
5360:
5336:
5295:
5102:
5093:
5048:
5028:
4977:
4911:
4855:
4744:
4735:
4715:
4616:
4571:
4530:
4430:
4376:
4338:
4280:
4237:
4164:
4155:
4146:
4107:
3984:
3893:
3884:
3839:
3784:
3712:
3697:
3461:
3255:
3004:
2688:
2411:
2071:
1669:
1486:Song J, So T, Cheng M, Tang X, Croft M (May 2005).
869:
848:
822:
801:
586:
negative regulation of transcription, DNA-templated
1153:
1151:
1149:
464:tumor necrosis factor-activated receptor activity
231:
4929:Granulocyte macrophage colony-stimulating factor
531:tumor necrosis factor-mediated signaling pathway
4690:
3675:
1638:
8:
1158:GRCh38: Ensembl release 89: ENSG00000186827
561:positive regulation of B cell proliferation
556:regulation of cell population proliferation
5696:Leukemia/leukocyte inhibitory factor (LIF)
5441:
5424:
5099:
4741:
4697:
4683:
4675:
4161:
4152:
3890:
3709:
3682:
3668:
3660:
1645:
1631:
1623:
636:
441:
272:
169:
63:
5691:FMS-like tyrosine kinase 3 ligand (FLT3L)
5120:Interferon alpha (interferon alfa, IFN-α)
1662:list of human clusters of differentiation
1575:
1503:
1431:
1359:
1310:
1269:
5713:Additional cytokine receptor modulators:
1607:10.1146/annurev.immunol.23.021704.115839
1145:
5537:Cucurbitacin I (elatericin B, JSI-124)
18:
4873:Granulocyte colony-stimulating factor
1334:Arch RH, Thompson CB (January 1998).
977:. OX40 is a secondary co-stimulatory
601:regulation of protein kinase activity
500:integral component of plasma membrane
236:
195:
190:
7:
5232:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
5005:Macrophage colony-stimulating factor
5706:Thymic stromal lymphopoietin (TSLP)
1299:The Journal of Biological Chemistry
1047:and memory cell generation whereas
866:
845:
819:
798:
774:
755:
731:
712:
686:
667:
541:multicellular organism development
411:
372:
310:
289:
14:
1093:An artificially created biologic
1071:OX40 has been implicated in the
510:external side of plasma membrane
415:
220:
213:
207:
182:
27:
5237:Interferon omega (IFN-ω, IFNW1)
526:regulation of apoptotic process
1340:Molecular and Cellular Biology
1242:Science Translational Medicine
551:response to lipopolysaccharide
485:integral component of membrane
426:More reference expression data
395:More reference expression data
1:
1577:10.1016/S1074-7613(01)00191-1
205:
16:Protein-coding gene in humans
1505:10.1016/j.immuni.2005.03.012
1254:10.1126/scitranslmed.aan4488
5778:Clusters of differentiation
5768:Genes on human chromosome 1
5081:Thrombopoietin (THPO, MGDF)
4847:Pegol sihematide (EPO-018B)
4767:Carbamylated erythropoietin
1658:clusters of differentiation
1595:Annual Review of Immunology
1433:10.4049/jimmunol.172.7.4292
571:apoptotic signaling pathway
5794:
1523:Nature Reviews. Immunology
1398:gene details page in the
576:viral entry into host cell
350:mucosa of transverse colon
5630:Tofacitinib (tasocitinib)
5587:Tofacitinib (tasocitinib)
5494:Tofacitinib (tasocitinib)
1193:"Mouse PubMed Reference:"
1175:"Human PubMed Reference:"
937:
932:
928:
921:
905:
888:
873:
852:
841:
826:
805:
794:
781:
777:
762:
758:
749:
738:
734:
719:
715:
706:
693:
689:
674:
670:
661:
646:
639:
635:
619:
596:cellular defense response
444:
440:
423:
414:
405:
392:
379:
375:
322:
313:
283:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
5308:Interferon gamma (IFN-γ)
1124:CD134 has been shown to
1089:As a drug or drug target
5208:Interferon beta (IFN-β)
1312:10.1074/jbc.273.10.5808
459:virus receptor activity
354:upper lobe of left lung
5686:Cardiotrophin 1 (CT-1)
4618:Enzyme-linked receptor
5683:Additional cytokines:
5610:Decernotinib (VX-509)
5247:Peginterferon alfa-2b
5242:Peginterferon alfa-2a
4762:Asialo erythropoietin
4440:Interleukin receptors
4348:Interleukin receptors
4290:Interleukin receptors
4247:Interleukin receptors
4174:Interleukin receptors
1420:Journal of Immunology
1067:Clinical significance
965:, is a member of the
894:Chr 1: 1.21 – 1.21 Mb
581:inflammatory response
5198:Interferon alfacon-1
4827:Erythropoietin (EPO)
4490:Interferon receptors
1392:genome location and
1352:10.1128/MCB.18.1.558
546:T cell proliferation
198:Chromosome 1 (human)
67:List of PDB id codes
40:Available structures
5345:See IL-28R (IFNLR)
5313:Interferon gamma 1b
5203:Interferon alpha-n3
1400:UCSC Genome Browser
1110:CpG oligonucleotide
1030:mediated reactions
162:TNFRSF4 - orthologs
5701:Oncostatin M (OSM)
5227:Interferon beta 1b
5222:Interferon beta 1a
5193:Interferon alfa n1
5188:Interferon alfa 2b
5183:Interferon alfa 2a
5017:Kinase inhibitors:
3699:Chemokine receptor
3691:Cytokine receptors
1217:on 4 February 2017
519:Biological process
478:Cellular component
452:Molecular function
5753:
5752:
5749:
5748:
5671:
5670:
5438:
5356:
5355:
5089:
5088:
4832:Erythropoietin-Fc
4706:Cytokine receptor
4672:
4671:
4526:
4525:
4426:
4425:
4142:
4141:
3880:
3879:
3657:
3656:
1451:Nature Immunology
1248:(426): eaan4488.
979:immune checkpoint
957:), also known as
948:
947:
944:
943:
917:
916:
884:
883:
863:
862:
837:
836:
816:
815:
790:
789:
771:
770:
745:
744:
728:
727:
702:
701:
683:
682:
631:
630:
436:
435:
432:
431:
401:
400:
388:
387:
369:
368:
267:
266:
94:
93:
90:
89:
50:Ortholog search:
5785:
5442:
5432:
5425:
5284:Decoy receptors:
5100:
4777:Darbepoetin alfa
4742:
4699:
4692:
4685:
4676:
4409:hormone receptor
4162:
4153:
3891:
3710:
3684:
3677:
3670:
3661:
1647:
1640:
1633:
1624:
1618:
1589:
1579:
1554:
1517:
1507:
1482:
1445:
1435:
1374:
1373:
1363:
1331:
1325:
1324:
1314:
1290:
1284:
1283:
1273:
1233:
1227:
1226:
1224:
1222:
1213:. Archived from
1207:
1201:
1200:
1189:
1183:
1182:
1171:
1165:
1155:
930:
929:
901:
896:
879:
867:
858:
846:
842:RefSeq (protein)
832:
820:
811:
799:
775:
756:
732:
713:
687:
668:
637:
442:
428:
419:
412:
397:
373:
346:cartilage tissue
318:
316:Top expressed in
311:
290:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
5793:
5792:
5788:
5787:
5786:
5784:
5783:
5782:
5758:
5757:
5754:
5745:
5667:
5663:Deucravacitinib
5649:
5591:
5503:
5431:
5416:
5396:
5376:
5352:
5332:
5291:
5125:Interferon alfa
5085:
5044:
5024:
4973:
4907:
4903:Pegnartograstim
4888:Lipegfilgrastim
4851:
4797:Epoetin epsilon
4731:
4711:
4703:
4673:
4668:
4612:
4567:
4522:
4422:
4372:
4334:
4276:
4233:
4138:
4103:
4032:Osteoprotegerin
3980:
3876:
3835:
3780:
3701:
3693:
3688:
3658:
3653:
3457:
3251:
3000:
2684:
2407:
2067:
1665:
1651:
1621:
1592:
1557:
1535:10.1038/nri1148
1520:
1485:
1448:
1413:
1409:
1407:Further reading
1383:
1378:
1377:
1333:
1332:
1328:
1305:(10): 5808–14.
1292:
1291:
1287:
1235:
1234:
1230:
1220:
1218:
1209:
1208:
1204:
1191:
1190:
1186:
1173:
1172:
1168:
1156:
1147:
1142:
1122:
1091:
1069:
999:
939:View/Edit Mouse
934:View/Edit Human
899:
892:
889:Location (UCSC)
875:
854:
828:
807:
722:ENSG00000186827
615:
566:immune response
514:
495:plasma membrane
473:
469:protein binding
424:
393:
384:
365:
360:
356:
352:
348:
344:
340:
336:
332:
328:
314:
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
5791:
5789:
5781:
5780:
5775:
5770:
5760:
5759:
5751:
5750:
5747:
5746:
5744:
5743:
5738:
5733:
5728:
5723:
5718:
5709:
5708:
5703:
5698:
5693:
5688:
5679:
5677:
5673:
5672:
5669:
5668:
5666:
5665:
5659:
5657:
5651:
5650:
5648:
5647:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5607:
5605:Cercosporamide
5601:
5599:
5593:
5592:
5590:
5589:
5584:
5579:
5574:
5569:
5564:
5559:
5554:
5549:
5547:Deuruxolitinib
5544:
5539:
5534:
5529:
5524:
5519:
5513:
5511:
5505:
5504:
5502:
5501:
5496:
5491:
5486:
5481:
5476:
5471:
5466:
5464:Deuruxolitinib
5461:
5456:
5450:
5448:
5439:
5422:
5418:
5417:
5415:
5414:
5406:
5404:
5398:
5397:
5395:
5394:
5386:
5384:
5378:
5377:
5375:
5374:
5366:
5364:
5358:
5357:
5354:
5353:
5351:
5350:
5342:
5340:
5338:IFNLR (λ, III)
5334:
5333:
5331:
5330:
5325:
5316:
5315:
5310:
5301:
5299:
5293:
5292:
5290:
5289:
5280:
5279:
5274:
5269:
5264:
5259:
5250:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5205:
5200:
5195:
5190:
5185:
5180:
5122:
5117:
5108:
5106:
5104:IFNAR (α/β, I)
5097:
5091:
5090:
5087:
5086:
5084:
5083:
5078:
5073:
5071:Promegapoietin
5068:
5063:
5054:
5052:
5050:Thrombopoietin
5046:
5045:
5043:
5042:
5034:
5032:
5026:
5025:
5023:
5022:
5013:
5012:
5007:
5002:
4997:
4995:Interleukin-34
4992:
4983:
4981:
4975:
4974:
4972:
4971:
4966:
4961:
4952:
4951:
4946:
4941:
4936:
4931:
4926:
4917:
4915:
4909:
4908:
4906:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4861:
4859:
4853:
4852:
4850:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4750:
4748:
4746:Erythropoietin
4739:
4733:
4732:
4730:
4729:
4721:
4719:
4713:
4712:
4704:
4702:
4701:
4694:
4687:
4679:
4670:
4669:
4667:
4666:
4665:
4664:
4659:
4654:
4640:
4639:
4638:
4633:
4622:
4620:
4614:
4613:
4611:
4610:
4609:
4608:
4603:
4598:
4593:
4588:
4577:
4575:
4569:
4568:
4566:
4565:
4556:
4555:
4554:
4549:
4539:
4536:
4534:
4532:Ig superfamily
4528:
4527:
4524:
4523:
4521:
4520:
4519:
4518:
4505:
4487:
4486:
4485:
4480:
4467:
4436:
4434:
4428:
4427:
4424:
4423:
4421:
4420:
4415:
4405:
4404:
4403:
4402:
4400:Thrombopoietin
4397:
4392:
4380:
4378:
4374:
4373:
4371:
4370:
4369:
4368:
4363:
4344:
4342:
4336:
4335:
4333:
4332:
4327:
4322:
4317:
4316:
4315:
4306:
4297:
4286:
4284:
4278:
4277:
4275:
4274:
4269:
4268:
4267:
4258:
4243:
4241:
4235:
4234:
4232:
4231:
4230:
4229:
4224:
4219:
4210:
4193:
4170:
4168:
4159:
4150:
4144:
4143:
4140:
4139:
4137:
4136:
4128:
4120:
4111:
4109:
4105:
4104:
4102:
4101:
4093:
4085:
4077:
4069:
4061:
4053:
4045:
4037:
4029:
4021:
4013:
4005:
3997:
3988:
3986:
3982:
3981:
3979:
3978:
3970:
3962:
3954:
3946:
3938:
3930:
3922:
3914:
3906:
3897:
3895:
3888:
3882:
3881:
3878:
3877:
3875:
3874:
3869:
3864:
3863:
3862:
3854:
3853:
3852:
3843:
3841:
3837:
3836:
3834:
3833:
3828:
3823:
3818:
3813:
3808:
3807:
3806:
3801:
3790:
3788:
3782:
3781:
3779:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3718:
3716:
3707:
3695:
3694:
3689:
3687:
3686:
3679:
3672:
3664:
3655:
3654:
3652:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3465:
3463:
3459:
3458:
3456:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3259:
3257:
3253:
3252:
3250:
3249:
3244:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3189:
3188:
3183:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3102:
3093:
3088:
3087:
3086:
3081:
3071:
3066:
3065:
3064:
3059:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3008:
3006:
3002:
3001:
2999:
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2923:
2918:
2913:
2912:
2911:
2906:
2896:
2891:
2886:
2881:
2880:
2879:
2874:
2869:
2859:
2854:
2849:
2844:
2839:
2838:
2837:
2832:
2822:
2817:
2812:
2807:
2802:
2797:
2792:
2791:
2790:
2785:
2775:
2769:
2764:
2759:
2754:
2745:
2740:
2739:
2738:
2733:
2728:
2718:
2713:
2708:
2703:
2698:
2692:
2690:
2686:
2685:
2683:
2682:
2677:
2672:
2667:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2556:
2555:
2550:
2540:
2539:
2538:
2533:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2463:
2462:
2461:
2456:
2446:
2441:
2436:
2431:
2426:
2421:
2415:
2413:
2409:
2408:
2406:
2405:
2400:
2395:
2390:
2385:
2380:
2375:
2370:
2365:
2356:
2351:
2346:
2341:
2336:
2331:
2330:
2329:
2324:
2319:
2314:
2309:
2304:
2294:
2289:
2284:
2279:
2274:
2269:
2268:
2267:
2262:
2252:
2247:
2242:
2237:
2232:
2227:
2222:
2217:
2212:
2211:
2210:
2205:
2200:
2195:
2190:
2185:
2175:
2174:
2173:
2168:
2163:
2153:
2148:
2147:
2146:
2141:
2136:
2126:
2121:
2116:
2111:
2106:
2101:
2096:
2091:
2086:
2081:
2075:
2073:
2069:
2068:
2066:
2065:
2060:
2059:
2058:
2053:
2048:
2043:
2038:
2033:
2023:
2018:
2013:
2008:
2003:
1998:
1993:
1992:
1991:
1986:
1981:
1976:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1920:
1919:
1914:
1904:
1899:
1894:
1889:
1884:
1879:
1874:
1869:
1864:
1859:
1854:
1849:
1844:
1839:
1834:
1833:
1832:
1827:
1817:
1812:
1807:
1802:
1801:
1800:
1795:
1790:
1785:
1775:
1770:
1765:
1764:
1763:
1753:
1748:
1743:
1738:
1733:
1732:
1731:
1726:
1721:
1711:
1706:
1705:
1704:
1699:
1694:
1689:
1684:
1673:
1671:
1667:
1666:
1652:
1650:
1649:
1642:
1635:
1627:
1620:
1619:
1590:
1555:
1518:
1483:
1463:10.1038/ni1030
1446:
1410:
1408:
1405:
1404:
1403:
1382:
1381:External links
1379:
1376:
1375:
1326:
1285:
1228:
1202:
1184:
1166:
1144:
1143:
1141:
1138:
1121:
1118:
1099:immunoglobulin
1095:fusion protein
1090:
1087:
1076:cytokine storm
1068:
1065:
998:
995:
946:
945:
942:
941:
936:
926:
925:
919:
918:
915:
914:
912:
910:
903:
902:
897:
890:
886:
885:
882:
881:
871:
870:
864:
861:
860:
850:
849:
843:
839:
838:
835:
834:
824:
823:
817:
814:
813:
803:
802:
796:
792:
791:
788:
787:
779:
778:
772:
769:
768:
760:
759:
753:
747:
746:
743:
742:
736:
735:
729:
726:
725:
717:
716:
710:
704:
703:
700:
699:
691:
690:
684:
681:
680:
672:
671:
665:
659:
658:
653:
648:
644:
643:
633:
632:
629:
628:
617:
616:
614:
613:
608:
603:
598:
593:
588:
583:
578:
573:
568:
563:
558:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
513:
512:
507:
502:
497:
492:
487:
481:
479:
475:
474:
472:
471:
466:
461:
455:
453:
449:
448:
438:
437:
434:
433:
430:
429:
421:
420:
409:
403:
402:
399:
398:
390:
389:
386:
385:
383:
380:
377:
376:
370:
367:
366:
364:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
320:
319:
307:
306:
298:
287:
281:
280:
277:RNA expression
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5790:
5779:
5776:
5774:
5771:
5769:
5766:
5765:
5763:
5756:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5711:
5710:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5681:
5680:
5678:
5674:
5664:
5661:
5660:
5658:
5656:
5652:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5602:
5600:
5598:
5594:
5588:
5585:
5583:
5580:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5514:
5512:
5510:
5506:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5451:
5449:
5447:
5443:
5440:
5436:
5430:
5426:
5423:
5419:
5412:
5408:
5407:
5405:
5403:
5399:
5392:
5388:
5387:
5385:
5383:
5379:
5372:
5368:
5367:
5365:
5363:
5359:
5348:
5344:
5343:
5341:
5339:
5335:
5329:
5326:
5324:
5321:
5318:
5317:
5314:
5311:
5309:
5306:
5303:
5302:
5300:
5298:
5297:IFNGR (γ, II)
5294:
5288:
5285:
5282:
5281:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5252:
5251:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5217:
5213:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5178:
5174:
5170:
5166:
5162:
5158:
5154:
5150:
5146:
5142:
5138:
5134:
5130:
5126:
5123:
5121:
5118:
5116:
5115:Albinterferon
5113:
5110:
5109:
5107:
5105:
5101:
5098:
5096:
5092:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5056:
5055:
5053:
5051:
5047:
5040:
5036:
5035:
5033:
5031:
5027:
5021:
5018:
5015:
5014:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4985:
4984:
4982:
4980:
4976:
4970:
4967:
4965:
4962:
4960:
4957:
4954:
4953:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4919:
4918:
4916:
4914:
4913:GM-CSF (CSF2)
4910:
4904:
4901:
4899:
4898:Pegfilgrastim
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4863:
4862:
4860:
4858:
4854:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4817:Epoetin theta
4815:
4813:
4812:Epoetin omega
4810:
4808:
4807:Epoetin kappa
4805:
4803:
4802:Epoetin gamma
4800:
4798:
4795:
4793:
4792:Epoetin delta
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4752:
4751:
4749:
4747:
4743:
4740:
4738:
4734:
4727:
4723:
4722:
4720:
4718:
4714:
4710:
4707:
4700:
4695:
4693:
4688:
4686:
4681:
4680:
4677:
4663:
4660:
4658:
4655:
4653:
4650:
4649:
4648:
4644:
4641:
4637:
4634:
4632:
4629:
4628:
4627:
4624:
4623:
4621:
4619:
4615:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4583:
4582:
4579:
4578:
4576:
4574:
4570:
4564:
4560:
4557:
4553:
4550:
4548:
4545:
4544:
4543:
4540:
4538:
4537:
4535:
4533:
4529:
4517:
4513:
4509:
4506:
4504:
4500:
4496:
4493:
4492:
4491:
4488:
4484:
4481:
4479:
4475:
4471:
4468:
4466:
4462:
4458:
4454:
4450:
4446:
4443:
4442:
4441:
4438:
4437:
4435:
4433:
4429:
4419:
4416:
4414:
4410:
4407:
4406:
4401:
4398:
4396:
4393:
4391:
4388:
4387:
4386:
4385:CSF receptors
4382:
4381:
4379:
4375:
4367:
4364:
4362:
4358:
4354:
4351:
4350:
4349:
4346:
4345:
4343:
4341:
4337:
4331:
4328:
4326:
4323:
4321:
4318:
4314:
4310:
4307:
4305:
4301:
4298:
4296:
4293:
4292:
4291:
4288:
4287:
4285:
4283:
4279:
4273:
4270:
4266:
4262:
4259:
4257:
4253:
4250:
4249:
4248:
4245:
4244:
4242:
4240:
4236:
4228:
4225:
4223:
4220:
4218:
4214:
4211:
4209:
4205:
4201:
4197:
4194:
4192:
4188:
4184:
4180:
4177:
4176:
4175:
4172:
4171:
4169:
4167:
4163:
4160:
4158:
4154:
4151:
4149:
4145:
4135:
4132:
4129:
4127:
4124:
4121:
4119:
4116:
4113:
4112:
4110:
4106:
4100:
4097:
4094:
4092:
4089:
4086:
4084:
4081:
4078:
4076:
4073:
4070:
4068:
4065:
4062:
4060:
4057:
4054:
4052:
4049:
4046:
4044:
4041:
4038:
4036:
4033:
4030:
4028:
4025:
4022:
4020:
4017:
4014:
4012:
4009:
4006:
4004:
4001:
3998:
3996:
3993:
3990:
3989:
3987:
3983:
3977:
3974:
3971:
3969:
3966:
3963:
3961:
3958:
3955:
3953:
3950:
3947:
3945:
3942:
3939:
3937:
3934:
3931:
3929:
3926:
3923:
3921:
3918:
3915:
3913:
3910:
3907:
3905:
3902:
3899:
3898:
3896:
3892:
3889:
3887:
3883:
3873:
3870:
3868:
3865:
3861:
3858:
3857:
3855:
3851:
3848:
3847:
3845:
3844:
3842:
3838:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3805:
3802:
3800:
3797:
3796:
3795:
3792:
3791:
3789:
3787:
3783:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3723:
3720:
3719:
3717:
3715:
3711:
3708:
3705:
3700:
3696:
3692:
3685:
3680:
3678:
3673:
3671:
3666:
3665:
3662:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3466:
3464:
3460:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3260:
3258:
3254:
3248:
3245:
3243:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3187:
3184:
3182:
3179:
3178:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3106:
3103:
3101:
3097:
3094:
3092:
3089:
3085:
3082:
3080:
3077:
3076:
3075:
3072:
3070:
3067:
3063:
3060:
3058:
3055:
3054:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3009:
3007:
3003:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2910:
2907:
2905:
2902:
2901:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2878:
2875:
2873:
2870:
2868:
2865:
2864:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2836:
2833:
2831:
2828:
2827:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2789:
2786:
2784:
2781:
2780:
2779:
2776:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2749:
2746:
2744:
2741:
2737:
2734:
2732:
2729:
2727:
2724:
2723:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2702:
2699:
2697:
2694:
2693:
2691:
2687:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2554:
2551:
2549:
2546:
2545:
2544:
2541:
2537:
2534:
2532:
2529:
2528:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2460:
2457:
2455:
2452:
2451:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2416:
2414:
2410:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2299:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2266:
2263:
2261:
2258:
2257:
2256:
2253:
2251:
2248:
2246:
2243:
2241:
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2184:
2181:
2180:
2179:
2176:
2172:
2169:
2167:
2164:
2162:
2159:
2158:
2157:
2154:
2152:
2149:
2145:
2142:
2140:
2137:
2135:
2132:
2131:
2130:
2127:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2076:
2074:
2070:
2064:
2061:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2028:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1999:
1997:
1994:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1971:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1918:
1915:
1913:
1910:
1909:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1831:
1828:
1826:
1823:
1822:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1799:
1796:
1794:
1791:
1789:
1786:
1784:
1781:
1780:
1779:
1776:
1774:
1771:
1769:
1766:
1762:
1759:
1758:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1730:
1727:
1725:
1722:
1720:
1717:
1716:
1715:
1712:
1710:
1707:
1703:
1700:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1679:
1678:
1675:
1674:
1672:
1668:
1663:
1659:
1655:
1648:
1643:
1641:
1636:
1634:
1629:
1628:
1625:
1616:
1612:
1608:
1604:
1600:
1596:
1591:
1587:
1583:
1578:
1573:
1570:(3): 445–55.
1569:
1565:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1529:(8): 609–20.
1528:
1524:
1519:
1515:
1511:
1506:
1501:
1498:(5): 621–31.
1497:
1493:
1489:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1447:
1443:
1439:
1434:
1429:
1426:(7): 4292–7.
1425:
1421:
1417:
1412:
1411:
1406:
1401:
1397:
1396:
1391:
1390:
1385:
1384:
1380:
1371:
1367:
1362:
1357:
1353:
1349:
1346:(1): 558–65.
1345:
1341:
1337:
1330:
1327:
1322:
1318:
1313:
1308:
1304:
1300:
1296:
1289:
1286:
1281:
1277:
1272:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1232:
1229:
1216:
1212:
1206:
1203:
1198:
1194:
1188:
1185:
1180:
1176:
1170:
1167:
1163:
1159:
1154:
1152:
1150:
1146:
1139:
1137:
1135:
1131:
1127:
1119:
1117:
1115:
1112:, which as a
1111:
1107:
1102:
1100:
1096:
1088:
1086:
1084:
1081:
1077:
1074:
1066:
1064:
1062:
1061:memory T cell
1058:
1054:
1050:
1046:
1042:
1037:
1035:
1034:
1029:
1025:
1020:
1016:
1012:
1008:
1004:
996:
994:
992:
988:
984:
980:
976:
972:
968:
964:
963:OX40 receptor
960:
956:
952:
940:
935:
931:
927:
924:
920:
913:
911:
908:
904:
898:
895:
891:
887:
880:
878:
872:
868:
865:
859:
857:
851:
847:
844:
840:
833:
831:
825:
821:
818:
812:
810:
804:
800:
797:
795:RefSeq (mRNA)
793:
786:
785:
780:
776:
773:
767:
766:
761:
757:
754:
752:
748:
741:
737:
733:
730:
724:
723:
718:
714:
711:
709:
705:
698:
697:
692:
688:
685:
679:
678:
673:
669:
666:
664:
660:
657:
654:
652:
649:
645:
642:
638:
634:
627:
623:
618:
612:
609:
607:
604:
602:
599:
597:
594:
592:
591:viral process
589:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
511:
508:
506:
503:
501:
498:
496:
493:
491:
488:
486:
483:
482:
480:
477:
476:
470:
467:
465:
462:
460:
457:
456:
454:
451:
450:
447:
446:Gene ontology
443:
439:
427:
422:
418:
413:
410:
408:
404:
396:
391:
381:
378:
374:
371:
361:
357:
353:
349:
345:
341:
337:
333:
329:
326:apex of heart
325:
324:
321:
317:
312:
309:
308:
305:
303:
299:
297:
296:
292:
291:
288:
286:
282:
278:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
5755:
5721:Lestaurtinib
5712:
5682:
5620:Ritlecitinib
5552:Lestaurtinib
5499:Upadacitinib
5328:Fontolizumab
5319:
5304:
5283:
5272:Rontalizumab
5253:
5111:
5066:Pegacaristim
5057:
5016:
4986:
4979:M-CSF (CSF1)
4959:Mavrilimumab
4955:
4949:Sargramostim
4939:Molgramostim
4924:Ecogramostim
4920:
4893:Nartograstim
4864:
4857:G-CSF (CSF3)
4842:Peginesatide
4822:Epoetin zeta
4787:Epoetin beta
4782:Epoetin alfa
4753:
4573:IL 17 family
4133:
4125:
4117:
4098:
4090:
4082:
4074:
4066:
4058:
4050:
4042:
4034:
4026:
4018:
4010:
4002:
3994:
3975:
3967:
3959:
3951:
3943:
3941:Fas receptor
3935:
3927:
3924:
3919:
3911:
3903:
3886:TNF receptor
3175:
3095:
3073:
3051:
2898:
2861:
2824:
2777:
2747:
2720:
2614:
2542:
2448:
2296:
2025:
1777:
1598:
1594:
1567:
1563:
1526:
1522:
1495:
1491:
1457:(2): 150–8.
1454:
1450:
1423:
1419:
1394:
1388:
1343:
1339:
1329:
1302:
1298:
1288:
1245:
1241:
1231:
1219:. Retrieved
1215:the original
1205:
1196:
1187:
1178:
1169:
1123:
1120:Interactions
1103:
1092:
1070:
1038:
1031:
1000:
962:
958:
954:
950:
949:
874:
853:
827:
806:
782:
763:
739:
720:
694:
675:
655:
650:
505:cell surface
300:
293:
121:External IDs
72:
5731:Quizartinib
5726:Midostaurin
5615:Peficitinib
5577:Ruxolitinib
5572:Peficitinib
5527:Baricitinib
5489:Ruxolitinib
5484:Peficitinib
5479:Oclacitinib
5474:Momelotinib
5459:Baricitinib
5454:Abrocitinib
5362:Interleukin
5320:Antibodies:
5277:Sifalimumab
5262:Faralimomab
5257:Anifrolumab
5254:Antibodies:
5076:Romiplostim
5061:Eltrombopag
5030:SCF (c-Kit)
4956:Antibodies:
4944:Regramostim
4878:Lenograstim
4059:(TNFRSF13C)
4051:(TNFRSF13B)
4043:(TNFRSF12A)
4035:(TNFRSF11B)
4027:(TNFRSF11A)
4019:(TNFRSF10D)
4011:(TNFRSF10C)
4003:(TNFRSF10B)
3995:(TNFRSF10A)
1039:OX40 binds
330:granulocyte
99:Identifiers
5762:Categories
5716:Emfilermin
5567:Pacritinib
5469:Filgotinib
5435:inhibitors
5323:Emapalumab
5095:Interferon
5020:Agerafenib
5010:Mirimostim
5000:Lanimostim
4934:Milodistim
4883:Leridistim
4868:Filgrastim
4709:modulators
4134:(TNFRSF27)
4126:(TNFRSF25)
4118:(TNFRSF21)
4099:(TNFRSF19)
4091:(TNFRSF18)
4083:(TNFRSF17)
4075:(TNFRSF16)
4067:(TNFRSF14)
3952:(TNFRSF6B)
3912:(TNFRSF1B)
3904:(TNFRSF1A)
1660:(see also
1164:, May 2017
1140:References
1073:pathologic
342:lymph node
304:(ortholog)
259:1,214,153
246:1,211,340
142:HomoloGene
5741:Sunitinib
5736:Sorafenib
5645:ZM-449829
5635:WHI-P 154
5625:TCS-21311
5562:NSC-33994
5517:Atiprimod
5305:Agonists:
5287:Bifarcept
5112:Agonists:
5058:Agonists:
4990:Cilmostim
4987:Agonists:
4964:Namilumab
4921:Agonists:
4865:Agonists:
4754:Agonists:
4717:Chemokine
4418:prolactin
3976:(TNFRSF9)
3968:(TNFRSF8)
3960:(TNFRSF7)
3944:(TNFRSF6)
3936:(TNFRSF5)
3928:(TNFRSF4)
3920:(TNFRSF3)
1601:: 23–68.
1262:1946-6234
1106:agonistic
973:, unlike
877:NP_035789
856:NP_003318
830:NM_011659
809:NM_003327
641:Orthologs
150:GeneCards
5640:ZM-39923
5557:NSC-7908
5522:AZD-1480
5413:instead.
5393:instead.
5373:instead.
5349:instead.
5267:MEDI-545
5041:instead.
4969:Otilimab
4772:CNTO-530
4728:instead.
4647:TGF-beta
4148:JAK-STAT
4096:TAJ/TROY
1654:Proteins
1615:15771565
1586:11567634
1564:Immunity
1551:10503208
1543:12974476
1514:15894279
1492:Immunity
1479:10102422
1471:14730361
1442:15034043
1280:29386357
1160:–
1126:interact
1083:bird flu
1019:cytokine
1015:survivin
997:Function
923:Wikidata
620:Sources:
490:membrane
362:appendix
5773:T cells
5582:SD-1008
4757:ARA-290
4643:Ser/Thr
4465:IL22RA2
4461:IL22RA1
4432:Type II
4361:IL12RB2
4357:IL12RB1
4340:IL12RB1
4239:β-chain
4208:IL13RA2
4204:IL13RA1
4166:γ-chain
3462:301–350
3256:251–300
3208:CD240CE
3005:201–250
2689:151–200
2412:101–150
1395:TNFRSF4
1389:TNFRSF4
1370:9418902
1321:9488716
1271:5997264
1221:6 April
1162:Ensembl
1097:, OX40-
1033:in vivo
971:T cells
955:TNFRSF4
751:UniProt
708:Ensembl
647:Species
626:QuickGO
279:pattern
238:1p36.33
154:TNFRSF4
113:TNFRSF4
106:Aliases
22:TNFRSF4
5676:Others
5542:CYT387
5532:CHZ868
5421:Others
5177:IFNA21
5173:IFNA17
5169:IFNA16
5165:IFNA14
5161:IFNA13
5157:IFNA10
4662:family
4657:TGFBR2
4652:TGFBR1
4606:IL17RE
4601:IL17RD
4596:IL17RC
4591:IL17RB
4586:IL17RA
4563:IL18R1
4516:IFNGR2
4512:IFNGR1
4503:IFNAR2
4499:IFNAR1
4478:IL20RB
4474:IL20RA
4453:IL10RB
4449:IL10RA
4383:other
4313:IL27RA
4304:IL11RA
4272:GM-CSF
4157:Type I
4040:TweakR
3872:CMKLR1
3850:CX3CR1
3469:CD300A
3428:CDw293
3213:CD240D
3074:CD213a
3052:CDw210
3017:CD202b
2991:CDw199
2986:CDw198
2640:CD140b
2072:51–100
1613:
1584:
1549:
1541:
1512:
1477:
1469:
1440:
1386:Human
1368:
1361:121523
1358:
1319:
1278:
1268:
1260:
1057:CTLA-4
1011:Bcl-XL
983:ligand
909:search
907:PubMed
784:P47741
765:P43489
663:Entrez
407:BioGPS
338:spleen
138:104512
130:600315
5216:IFNB3
5212:IFNB1
5153:IFNA8
5149:IFNA7
5145:IFNA6
5141:IFNA5
5137:IFNA4
5133:IFNA2
5129:IFNA1
4631:CSF1R
4559:IL18R
4552:IL1R2
4547:IL1R1
4483:IL28R
4470:IL20R
4457:IL22R
4445:IL10R
4395:G-CSF
4377:Other
4366:IL23R
4353:IL12R
4330:CNTFR
4295:IL6RA
4282:gp130
4265:IL5RA
4256:IL3RA
4227:IL21R
4217:IL7RA
4200:IL13R
4191:IL15R
4187:IL2RB
4183:IL2RA
4131:EDA2R
4108:21-27
4056:BAFFR
3985:11-20
3973:CD137
3925:CD134
3909:TNFR2
3901:TNFR1
3867:CCBP2
3846:CX3C
3840:Other
3831:CXCR7
3826:CXCR6
3821:CXCR5
3816:CXCR4
3811:CXCR3
3804:CXCR2
3799:CXCR1
3776:CCR10
3736:CCRL2
3726:CCRL1
3704:GPCRs
3649:CD350
3644:CD349
3639:CD344
3634:CD340
3629:CD339
3624:CD338
3619:CD337
3614:CD336
3609:CD335
3604:CD334
3599:CD333
3594:CD332
3589:CD331
3584:CD329
3579:CD328
3574:CD327
3569:CD326
3564:CD325
3559:CD324
3554:CD322
3549:CD321
3544:CD320
3539:CD318
3534:CD317
3529:CD316
3524:CD315
3519:CD314
3514:CD312
3509:CD309
3504:CD307
3499:CD306
3494:CD305
3489:CD304
3484:CD303
3479:CD302
3474:CD301
3453:CD299
3448:CD298
3443:CD297
3438:CD295
3433:CD294
3423:CD292
3418:CD290
3413:CD289
3408:CD288
3403:CD286
3398:CD284
3393:CD283
3388:CD282
3383:CD281
3378:CD280
3373:CD279
3368:CD278
3363:CD276
3358:CD275
3353:CD274
3348:CD273
3343:CD272
3338:CD271
3333:CD269
3328:CD268
3323:CD267
3318:CD266
3313:CD265
3308:CD264
3303:CD263
3298:CD262
3293:CD261
3288:CD258
3283:CD257
3278:CD256
3273:CD254
3268:CD253
3263:CD252
3247:CD249
3242:CD248
3238:CD247
3233:CD246
3228:CD244
3223:CD243
3218:CD241
3203:CD239
3198:CD238
3193:CD236
3176:CD235
3171:CD234
3166:CD233
3161:CD230
3156:CD229
3151:CD228
3146:CD227
3141:CD226
3136:CD225
3131:CD224
3126:CD223
3121:CD222
3116:CD221
3111:CD220
3096:CD218
3091:CD217
3069:CD212
3047:CD209
3042:CD208
3037:CD207
3032:CD206
3027:CD205
3022:CD204
3012:CD201
2996:CD200
2981:CD197
2976:CD196
2971:CD195
2966:CD194
2961:CD193
2956:CD192
2951:CD191
2946:CD186
2941:CD185
2936:CD184
2931:CD183
2926:CD182
2921:CD181
2916:CD180
2899:CD179
2894:CD178
2889:CD177
2884:CD174
2862:CD172
2857:CD171
2852:CD170
2847:CD169
2842:CD168
2825:CD167
2820:CD166
2815:CD164
2810:CD163
2805:CD162
2800:CD161
2795:CD160
2778:CD159
2748:CD158
2743:CD157
2721:CD156
2716:CD155
2711:CD154
2706:CD153
2701:CD152
2696:CD151
2680:CD150
2675:CD148
2670:CD147
2665:CD146
2660:CD144
2655:CD143
2650:CD142
2645:CD141
2635:CD138
2630:CD137
2625:CD136
2620:CD135
2615:CD134
2610:CD133
2605:CD132
2600:CD131
2595:CD130
2590:CD129
2585:CD127
2580:CD126
2575:CD125
2570:CD124
2565:CD123
2560:CD122
2543:CD121
2526:CD120
2521:CD119
2516:CD118
2511:CD117
2506:CD116
2501:CD115
2496:CD114
2491:CD113
2486:CD112
2481:CD111
2476:CD110
2471:CD109
2466:CD108
2449:CD107
2444:CD106
2439:CD105
2434:CD104
2429:CD103
2424:CD102
2419:CD101
2403:CD100
1547:S2CID
1475:S2CID
1134:TRAF2
1130:TRAF5
1128:with
1053:TRAF3
1049:TRAF5
1045:NF-κB
1041:TRAF2
1007:Bcl-2
987:OX40L
959:CD134
696:22163
656:Mouse
651:Human
622:Amigo
358:blood
334:gonad
302:Mouse
295:Human
242:Start
175:Human
5655:TYK2
5597:JAK3
5509:JAK2
5446:JAK1
5411:here
5409:See
5391:here
5389:See
5382:TGFβ
5371:here
5369:See
5347:here
5039:here
5037:See
4726:here
4724:See
4581:IL17
4495:-α/β
4325:LIFR
4320:OSMR
4261:IL5R
4252:IL3R
4222:IL9R
4213:IL7R
4196:IL4R
4179:IL2R
4088:GITR
4080:BCMA
4072:NGFR
4064:HVEM
4048:TACI
4024:RANK
4016:DcR2
4008:DcR1
3965:CD30
3957:CD27
3949:DcR3
3933:CD40
3917:LTBR
3894:1-10
3860:XCR1
3794:IL-8
3771:CCR9
3766:CCR8
3761:CCR7
3756:CCR6
3751:CCR5
3746:CCR4
3741:CCR3
3731:CCR2
3722:CCR1
2398:CD99
2393:CD98
2388:CD97
2383:CD96
2378:CD95
2373:CD94
2368:CD93
2363:CD92
2359:CD91
2354:CD90
2349:CD89
2344:CD88
2339:CD87
2334:CD86
2297:CD85
2292:CD84
2287:CD83
2282:CD82
2277:CD81
2272:CD80
2255:CD79
2250:CD78
2245:CD74
2240:CD73
2235:CD72
2230:CD71
2225:CD70
2220:CD69
2215:CD68
2178:CD66
2156:CD64
2151:CD63
2129:CD62
2124:CD61
2119:CD59
2114:CD58
2109:CD57
2104:CD56
2099:CD55
2094:CD54
2089:CD53
2084:CD52
2079:CD51
2063:CD50
2026:CD49
2021:CD48
2016:CD47
2011:CD46
2006:CD45
2001:CD44
1996:CD43
1969:CD42
1964:CD41
1959:CD40
1954:CD39
1949:CD38
1944:CD37
1939:CD36
1934:CD35
1929:CD34
1924:CD33
1907:CD32
1902:CD31
1897:CD30
1892:CD29
1887:CD28
1882:CD27
1877:CD26
1872:CD25
1867:CD24
1862:CD23
1857:CD22
1852:CD21
1847:CD20
1842:CD19
1837:CD18
1820:CD16
1815:CD15
1810:CD14
1805:CD13
1778:CD11
1773:CD10
1670:1–50
1611:PMID
1582:PMID
1539:PMID
1510:PMID
1467:PMID
1438:PMID
1366:PMID
1317:PMID
1276:PMID
1258:ISSN
1223:2016
1132:and
1114:TLR9
1080:H5N1
1026:and
1013:and
1003:CD4+
991:CD28
975:CD28
967:TNFR
961:and
677:7293
285:Bgee
233:Band
192:Chr.
146:2496
126:OMIM
83:2HEY
79:2HEV
75:1D0A
56:RCSB
53:PDBe
5429:JAK
5402:TNF
4737:CSF
4636:KIT
4626:Tyr
4542:IL1
4390:EPO
4123:DR3
4115:DR6
4000:DR5
3992:DR4
3856:XC
3786:CXC
1768:CD9
1756:CD8
1751:CD7
1746:CD6
1741:CD5
1736:CD4
1714:CD3
1709:CD2
1682:a-c
1677:CD1
1603:doi
1572:doi
1531:doi
1500:doi
1459:doi
1428:doi
1424:172
1356:PMC
1348:doi
1307:doi
1303:273
1266:PMC
1250:doi
1028:Th2
1024:Th1
900:n/a
740:n/a
382:n/a
255:End
158:OMA
134:MGI
46:PDB
5764::
5214:,
5175:,
5171:,
5167:,
5163:,
5159:,
5155:,
5151:,
5147:,
5143:,
5139:,
5135:,
5131:,
4645::
4561:/
4514:/
4508:-γ
4497:/
4476:/
4472:/
4463:/
4459:/
4455:/
4451:/
4447:/
4413:GH
4411::
4309:27
4300:11
4263:/
4254:/
4215:/
4206:/
4202:/
4198:/
4189:/
4181:/
3724:/
3714:CC
3240:-
2361:-
1702:1E
1697:1D
1692:1B
1687:1A
1656::
1609:.
1599:23
1597:.
1580:.
1568:15
1566:.
1562:.
1545:.
1537:.
1525:.
1508:.
1496:22
1494:.
1490:.
1473:.
1465:.
1453:.
1436:.
1422:.
1418:.
1364:.
1354:.
1344:18
1342:.
1338:.
1315:.
1301:.
1297:.
1274:.
1264:.
1256:.
1246:10
1244:.
1240:.
1195:.
1177:.
1148:^
1136:.
1085:.
1036:.
1009:,
985:,
624:/
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
5437:)
5433:(
5218:)
5210:(
5179:)
5127:(
4698:e
4691:t
4684:v
4510:/
4501:/
4359:/
4355:/
4311:/
4302:/
4185:/
3706:)
3702:(
3683:e
3676:t
3669:v
3186:b
3181:a
3107:)
3105:b
3100:a
3098:(
3084:2
3079:1
3062:b
3057:a
2909:b
2904:a
2877:g
2872:b
2867:a
2835:b
2830:a
2788:c
2783:a
2774:)
2772:k
2767:i
2762:e
2757:d
2752:a
2750:(
2736:c
2731:b
2726:a
2553:b
2548:a
2536:b
2531:a
2459:b
2454:a
2327:k
2322:j
2317:h
2312:e
2307:d
2302:a
2265:b
2260:a
2208:f
2203:e
2198:d
2193:c
2188:b
2183:a
2171:C
2166:B
2161:A
2144:P
2139:L
2134:E
2056:f
2051:e
2046:d
2041:c
2036:b
2031:a
1989:d
1984:c
1979:b
1974:a
1917:B
1912:A
1830:B
1825:A
1798:d
1793:c
1788:b
1783:a
1761:a
1729:ε
1724:δ
1719:γ
1664:)
1646:e
1639:t
1632:v
1617:.
1605::
1588:.
1574::
1553:.
1533::
1527:3
1516:.
1502::
1481:.
1461::
1455:5
1444:.
1430::
1402:.
1372:.
1350::
1323:.
1309::
1282:.
1252::
1225:.
1199:.
1181:.
953:(
177:)
160::
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