355:
332:
229:
254:
2556:
613:
2496:
2541:
606:
2526:
361:
260:
42:
2511:
2448:
1392:
Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van
Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts".
68:
2072:
Yonezawa S, Maruyama I, Tanaka S, Nakamura T, Sato E (August 1988). "Immunohistochemical localization of thrombomodulin in chorionic diseases of the uterus and choriocarcinoma of the stomach. A comparative study with the distribution of human chorionic gonadotropin".
1238:
pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving
2254:"Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474"
2223:
Srinivasan J, Hu S, Hrabal R, Zhu Y, Komives EA, Ni F (November 1994). "Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear
Overhauser effects".
2033:
Shirai T, Shiojiri S, Ito H, Yamamoto S, Kusumoto H, Deyashiki Y, et al. (February 1988). "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C".
3457:
1656:
Dzionek A, Inagaki Y, Okawa K, Nagafune J, RΓΆck J, Sohma Y, et al. (December 2002). "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions".
2596:
2555:
368:
267:
3447:
1265:
described as BDCA-3 has turned out to be identical to thrombomodulin. Thus, it was revealed that this molecule also occurs on a very rare (0.02%) subset of human
2004:
Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (July 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene".
1436:
Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (July 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene".
2295:
Yasuda K, Espinosa R, Davis EM, Le Beau MM, Bell GI (September 1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2".
2495:
1910:"Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control"
3427:
871:
852:
4289:
2613:
2589:
190:
2540:
4020:
2525:
1858:
Van de Wouwer M, Collen D, Conway EM (August 2004). "Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation".
4008:
3786:
4621:
4072:
4067:
4013:
3793:
2574:
2475:
1362:
1344:
4631:
3526:
3452:
2582:
2324:
Yamamoto S, Mizoguchi T, Tamaki T, Ohkuchi M, Kimura S, Aoki N (April 1993). "Urinary thrombomodulin, its isolation and characterization".
4555:
4550:
4545:
4540:
3467:
2086:
354:
1693:"TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex"
1255:
1078:
1071:
4520:
1963:"Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation"
331:
3756:
2510:
4324:
3818:
3504:
1331:
1310:
2399:, Feldblyum TV, Durkin AS, Nierman WC (May 1996). "Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)".
3963:
3499:
253:
228:
2155:"The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin"
1327:
65:
4460:
3932:
3927:
3872:
3606:
3055:
1780:"Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface"
1306:
4154:
3877:
170:
4626:
3472:
2190:"The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease"
1278:
1254:
inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with
367:
266:
4184:
2609:
1138:
3050:
2468:
1142:
360:
259:
4234:
3129:
916:
178:
1617:"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood"
4198:
1223:
897:
3541:
3536:
3531:
3521:
2828:
2756:
2042:
1887:
Boffa MC, Jackman RW, Peyri N, Boffa JF, George B (1991). "Thrombomodulin in the central nervous system".
1821:
Ohlin AK, Norlund L, Marlar RA (July 1997). "Thrombomodulin gene variations and thromboembolic disease".
2885:
2803:
242:
4122:
3835:
2461:
2047:
1921:
1211:
157:
4149:
3968:
1240:
3556:
3290:
2424:
2098:
1846:
1809:
1499:
1418:
202:
2355:"Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin"
1054:
1033:
1007:
986:
2416:
2384:
2341:
2312:
2283:
2240:
2211:
2176:
2141:
2090:
2060:
2021:
1992:
1949:
1896:
1875:
1838:
1801:
1755:
1714:
1673:
1638:
1597:
1548:
1491:
1453:
1410:
1154:
150:
58:
1961:
Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, et al. (July 1987).
1183:
4329:
4062:
3983:
3546:
2739:
2665:
2408:
2396:
2374:
2366:
2333:
2304:
2273:
2265:
2232:
2201:
2166:
2131:
2123:
2082:
2052:
2013:
1982:
1974:
1939:
1929:
1867:
1830:
1791:
1745:
1704:
1665:
1628:
1587:
1579:
1538:
1530:
1483:
1445:
1402:
1162:
1146:
612:
447:
378:
322:
277:
4389:
2925:
2920:
2843:
2337:
2056:
1615:
Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, et al. (December 2000).
1566:
Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, et al. (July 2009).
1195:
605:
422:
198:
1925:
1406:
4174:
3107:
2910:
2379:
2354:
2278:
2253:
1978:
1871:
1734:"Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin"
1592:
1567:
1543:
1518:
1471:
1266:
1170:
2136:
2111:
1987:
1962:
1944:
1909:
1750:
1733:
1669:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
720:
715:
710:
705:
700:
695:
690:
685:
669:
664:
659:
654:
41:
4615:
4144:
3601:
2692:
1519:"C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation"
1250:
on the surface of endothelial cells that, in addition to binding thrombin, regulates
1235:
1207:
1191:
641:
2564:: FIFTH EGF-LIKE DOMAIN OF THROMBOMODULIN (TMEGF5), NMR, MINIMIZED AVERAGE STRUCTURE
2428:
2252:
Gerlitz B, Hassell T, Vlahos CJ, Parkinson JF, Bang NU, Grinnell BW (October 1993).
2102:
1850:
1813:
1503:
1379:
4500:
3808:
3798:
3329:
3295:
1422:
1247:
440:
219:
182:
1633:
1616:
206:
4510:
4159:
3937:
3912:
3611:
3233:
3159:
2633:
2206:
2189:
1796:
1779:
1367:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1349:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1914:
Proceedings of the
National Academy of Sciences of the United States of America
523:
4440:
4164:
3845:
3586:
3462:
3095:
3090:
3085:
2940:
2724:
2443:
2087:
10.1002/1097-0142(19880801)62:3<569::AID-CNCR2820620322>3.0.CO;2-T
339:
236:
186:
2171:
2154:
1709:
1692:
4279:
4274:
4269:
4259:
4254:
4249:
4244:
1934:
1231:
1203:
816:
583:
461:
406:
393:
305:
292:
194:
2370:
2308:
1879:
1834:
1677:
1642:
1601:
1552:
1487:
2420:
2412:
2388:
2345:
2316:
2287:
2244:
2215:
2180:
2145:
2094:
2064:
2025:
1996:
1953:
1900:
1842:
1805:
1759:
1718:
1583:
1495:
1457:
1414:
1118:
1113:
4585:
4485:
4299:
4284:
3487:
3482:
3390:
3080:
2153:
Adler M, Seto MH, Nitecki DE, Lin JH, Light DR, Morser J (October 1995).
1282:
1227:
1166:
1150:
1102:
961:
942:
2236:
2017:
1908:
Jackman RW, Beeler DL, Fritze L, Soff G, Rosenberg RD (September 1987).
1449:
4535:
4530:
4525:
4425:
4239:
4229:
4056:
4035:
4030:
3998:
3803:
3723:
3718:
3713:
3708:
3703:
3621:
3314:
3154:
3149:
3144:
3139:
3134:
2605:
1534:
1262:
928:
883:
2504:: FIFTH EGF-LIKE DOMAIN OF THROMBOMODULIN (TMEGF5), NMR, 14 STRUCTURES
2269:
2127:
1161:
from a procoagulant enzyme. Thrombomodulin is also expressed on human
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
4475:
4435:
4420:
4404:
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4379:
4374:
4309:
4117:
4087:
4051:
4042:
3855:
3823:
3687:
3682:
3652:
3631:
3591:
3551:
3417:
3395:
3354:
3278:
3273:
3268:
3263:
3258:
3253:
3122:
3117:
3112:
3060:
3045:
2915:
2905:
2868:
2863:
2781:
2776:
1199:
1158:
1086:
838:
17:
2444:
GeneReviews/NCBI/NIH/UW entry on
Atypical Hemolytic-Uremic Syndrome
4600:
4575:
4495:
4490:
4480:
4470:
4455:
4450:
4445:
4430:
4384:
4369:
4334:
4319:
4314:
4304:
4224:
4219:
4214:
4193:
4189:
4179:
4092:
3993:
3988:
3947:
3897:
3892:
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3882:
3867:
3860:
3840:
3828:
3771:
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3761:
3751:
3746:
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3667:
3662:
3657:
3647:
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3616:
3581:
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3571:
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3511:
3477:
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3422:
3410:
3405:
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3375:
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3211:
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3014:
3007:
3002:
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2992:
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2935:
2930:
2823:
2749:
2744:
2734:
801:
797:
4595:
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4560:
4515:
4505:
4465:
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4364:
4359:
4354:
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4264:
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4137:
4132:
4112:
4102:
4097:
4082:
4077:
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3973:
3942:
3922:
3917:
3907:
3902:
3781:
3734:
3694:
3349:
3344:
3339:
3334:
3319:
3310:
3305:
3300:
3285:
3243:
3238:
3228:
3223:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3102:
3075:
3070:
3065:
3040:
3035:
2972:
2967:
2962:
2952:
2947:
2900:
2895:
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2880:
2875:
2858:
2853:
2848:
2838:
2833:
2818:
2813:
2808:
2798:
2793:
2788:
2771:
2766:
2761:
2712:
2680:
2675:
2670:
2653:
2648:
2643:
2638:
1568:"Thrombomodulin mutations in atypical hemolytic-uremic syndrome"
1187:
174:
2578:
2457:
1517:
Khan KA, McMurray JL, Mohammed F, Bicknell R (September 2019).
621:
161:, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
4107:
2719:
2707:
2702:
2697:
2687:
2660:
2628:
2549:: FOURTH EGF-LIKE DOMAIN OF THROMBOMODULIN, NMR, 12 STRUCTURES
2453:
1251:
1194:, and consists of a single chain with six tandemly repeated
2534:: CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX
430:
2353:
Meininger DP, Hunter MJ, Komives EA (September 1995).
1474:(July 1997). "Thrombomodulin structure and function".
1243:(TAFI, aka carboxypeptidase B2) into its active form.
2112:"Thrombomodulin is present in human plasma and urine"
1269:
called MDC2. Its function on these cells is unknown.
595:
4413:
4207:
3956:
3640:
3363:
3023:
2621:
1047:
1026:
1000:
979:
2449:OMIM entries on Atypical Hemolytic-Uremic Syndrome
1860:Arteriosclerosis, Thrombosis, and Vascular Biology
1323:
1321:
1319:
1302:
1300:
1298:
377:
276:
1328:GRCm38: Ensembl release 89: ENSMUSG00000074743
2590:
2469:
8:
1181:In humans, thrombomodulin is encoded by the
1691:Bajzar L, Morser J, Nesheim M (July 1996).
1307:GRCh38: Ensembl release 89: ENSG00000178726
1241:thrombin-activatable fibrinolysis inhibitor
1157:by converting thrombin to an anticoagulant
2597:
2583:
2575:
2519:: NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)
2476:
2462:
2454:
812:
747:negative regulation of platelet activation
637:
418:
317:
214:
76:
2614:list of human clusters of differentiation
2378:
2277:
2205:
2170:
2135:
2046:
1986:
1943:
1933:
1795:
1749:
1708:
1632:
1591:
1542:
1190:. The protein has a molecular mass of 74k
665:transmembrane signaling receptor activity
782:negative regulation of blood coagulation
2491:
1294:
27:Mammalian protein found in Homo sapiens
1889:Nouvelle Revue Française d'Hématologie
31:
2338:10.1093/oxfordjournals.jbchem.a124063
2116:The Journal of Clinical Investigation
2110:Ishii H, Majerus PW (December 1985).
2057:10.1093/oxfordjournals.jbchem.a122261
701:integral component of plasma membrane
382:
343:
338:
281:
240:
235:
7:
2188:Ohlin AK, Marlar RA (January 1995).
1732:Jakubowski HV, Owen WG (July 1989).
2159:The Journal of Biological Chemistry
1738:The Journal of Biological Chemistry
1697:The Journal of Biological Chemistry
1572:The New England Journal of Medicine
1407:10.1046/j.1365-2141.1996.d01-1935.x
762:negative regulation of fibrinolysis
1979:10.1002/j.1460-2075.1987.tb02448.x
1872:10.1161/01.ATV.0000134298.25489.92
1256:atypical hemolytic-uremic syndrome
1044:
1023:
997:
976:
952:
933:
907:
888:
862:
843:
600:
518:
456:
435:
25:
1277:Thrombomodulin has been shown to
2554:
2539:
2524:
2509:
2494:
611:
604:
366:
359:
353:
330:
265:
258:
252:
227:
40:
1395:British Journal of Haematology
1222:Thrombomodulin functions as a
1210:domain. It is a member of the
752:response to lipopolysaccharide
686:integral component of membrane
622:More reference expression data
584:More reference expression data
1:
1751:10.1016/S0021-9258(18)60437-5
1670:10.1016/S0198-8859(02)00752-8
1149:and serves as a cofactor for
351:
250:
4622:Genes on human chromosome 20
1634:10.4049/jimmunol.165.11.6037
1145:expressed on the surface of
711:apicolateral plasma membrane
4632:Clusters of differentiation
2610:clusters of differentiation
2207:10.1182/blood.V85.2.330.330
1797:10.1096/fasebj.9.10.7615164
670:signaling receptor activity
4648:
1823:Thrombosis and Haemostasis
1476:Thrombosis and Haemostasis
1382:Accessed January 19, 2012.
2489:
1363:"Mouse PubMed Reference:"
1345:"Human PubMed Reference:"
1143:integral membrane protein
1117:
1112:
1108:
1101:
1085:
1079:Chr 2: 148.25 β 148.25 Mb
1066:
1051:
1030:
1019:
1004:
983:
972:
959:
955:
940:
936:
927:
914:
910:
895:
891:
882:
869:
865:
850:
846:
837:
822:
815:
811:
795:
640:
636:
619:
603:
594:
581:
530:
521:
468:
459:
429:
421:
417:
400:
387:
350:
329:
320:
316:
299:
286:
249:
226:
217:
213:
168:
165:
155:
148:
143:
84:
79:
62:
57:
52:
48:
39:
34:
2172:10.1074/jbc.270.40.23366
1710:10.1074/jbc.271.28.16603
1380:IPR001491 Thrombomodulin
1214:(CTLD) group 14 family.
1072:Chr 20: 23.05 β 23.05 Mb
2326:Journal of Biochemistry
2258:The Biochemical Journal
2035:Journal of Biochemistry
1935:10.1073/pnas.84.18.6425
1230:-induced activation of
504:upper lobe of left lung
2371:10.1002/pro.5560040904
2309:10.1006/geno.1993.1410
1835:10.1055/s-0038-1657559
1778:Esmon CT (July 1995).
1488:10.1055/s-0038-1657558
1177:Genetics and structure
2413:10.1007/s003359900120
1621:Journal of Immunology
1584:10.1056/NEJMoa0810739
243:Chromosome 20 (human)
1246:Thrombomodulin is a
1212:C-type lectin domain
1141:141 or BDCA-3 is an
566:white adipose tissue
508:left coronary artery
384:2 G3|2 73.45 cM
345:Chromosome 2 (mouse)
80:List of PDB id codes
53:Available structures
2237:10.1021/bi00250a007
2231:(46): 13553β13560.
2165:(40): 23366β23372.
2018:10.1021/bi00388a025
1926:1987PNAS...84.6425J
1744:(19): 11117β11121.
1703:(28): 16603β16608.
1450:10.1021/bi00388a025
1206:-rich spacer and a
787:leukocyte migration
777:signal transduction
721:extracellular space
655:calcium ion binding
472:gingival epithelium
4627:Coagulation system
1535:10.1111/febs.14985
917:ENSMUSG00000074743
730:Biological process
679:Cellular component
648:Molecular function
500:lower lobe of lung
4609:
4608:
2572:
2571:
2270:10.1042/bj2950131
2128:10.1172/JCI112225
2012:(14): 4350β4357.
1920:(18): 6425β6429.
1664:(12): 1133β1148.
1627:(11): 6037β6046.
1529:(17): 3299β3332.
1444:(14): 4350β4357.
1155:blood coagulation
1147:endothelial cells
1128:
1127:
1124:
1123:
1097:
1096:
1062:
1061:
1041:
1040:
1015:
1014:
994:
993:
968:
967:
949:
948:
923:
922:
904:
903:
878:
877:
859:
858:
807:
806:
772:response to X-ray
767:blood coagulation
716:vacuolar membrane
632:
631:
628:
627:
590:
589:
577:
576:
515:
514:
496:periodontal fiber
413:
412:
312:
311:
139:
138:
135:
134:
63:Ortholog search:
16:(Redirected from
4639:
2599:
2592:
2585:
2576:
2558:
2543:
2528:
2513:
2498:
2478:
2471:
2464:
2455:
2432:
2401:Mammalian Genome
2392:
2382:
2365:(9): 1683β1695.
2349:
2320:
2291:
2281:
2248:
2219:
2209:
2184:
2174:
2149:
2139:
2122:(6): 2178β2181.
2106:
2068:
2050:
2048:10.1.1.1006.6759
2029:
2000:
1990:
1973:(7): 1891β1897.
1967:The EMBO Journal
1957:
1947:
1937:
1904:
1883:
1866:(8): 1374β1383.
1854:
1817:
1799:
1764:
1763:
1753:
1729:
1723:
1722:
1712:
1688:
1682:
1681:
1658:Human Immunology
1653:
1647:
1646:
1636:
1612:
1606:
1605:
1595:
1563:
1557:
1556:
1546:
1523:The FEBS Journal
1514:
1508:
1507:
1468:
1462:
1461:
1433:
1427:
1426:
1389:
1383:
1377:
1371:
1370:
1359:
1353:
1352:
1341:
1335:
1325:
1314:
1304:
1196:EGF-like domains
1163:mesothelial cell
1110:
1109:
1081:
1074:
1057:
1045:
1036:
1024:
1020:RefSeq (protein)
1010:
998:
989:
977:
953:
934:
908:
889:
863:
844:
813:
757:response to cAMP
742:female pregnancy
638:
624:
615:
608:
601:
586:
526:
524:Top expressed in
519:
464:
462:Top expressed in
457:
436:
419:
409:
396:
385:
370:
363:
357:
346:
334:
318:
308:
295:
284:
269:
262:
256:
245:
231:
215:
209:
207:THBD - orthologs
160:
153:
130:
77:
71:
50:
49:
44:
32:
21:
4647:
4646:
4642:
4641:
4640:
4638:
4637:
4636:
4612:
4611:
4610:
4605:
4409:
4203:
3952:
3636:
3359:
3019:
2617:
2603:
2573:
2568:
2565:
2559:
2550:
2544:
2535:
2529:
2520:
2514:
2505:
2499:
2485:
2482:
2440:
2435:
2395:
2359:Protein Science
2352:
2323:
2294:
2251:
2222:
2187:
2152:
2109:
2071:
2032:
2003:
1960:
1907:
1886:
1857:
1820:
1790:(10): 946β955.
1777:
1773:
1771:Further reading
1768:
1767:
1731:
1730:
1726:
1690:
1689:
1685:
1655:
1654:
1650:
1614:
1613:
1609:
1565:
1564:
1560:
1516:
1515:
1511:
1470:
1469:
1465:
1435:
1434:
1430:
1391:
1390:
1386:
1378:
1374:
1361:
1360:
1356:
1343:
1342:
1338:
1326:
1317:
1305:
1296:
1291:
1275:
1267:dendritic cells
1220:
1179:
1119:View/Edit Mouse
1114:View/Edit Human
1077:
1070:
1067:Location (UCSC)
1053:
1032:
1006:
985:
898:ENSG00000178726
791:
725:
696:plasma membrane
674:
660:protein binding
620:
610:
609:
582:
573:
568:
564:
562:ascending aorta
560:
556:
552:
548:
544:
540:
536:
534:right lung lobe
522:
511:
506:
502:
498:
494:
490:
488:skin of abdomen
486:
482:
478:
474:
460:
404:
391:
383:
373:
372:
371:
364:
344:
321:Gene location (
303:
290:
282:
272:
271:
270:
263:
241:
218:Gene location (
169:
156:
149:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4645:
4643:
4635:
4634:
4629:
4624:
4614:
4613:
4607:
4606:
4604:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4417:
4415:
4411:
4410:
4408:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4211:
4209:
4205:
4204:
4202:
4201:
4196:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4141:
4140:
4135:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4054:
4045:
4040:
4039:
4038:
4033:
4023:
4018:
4017:
4016:
4011:
4001:
3996:
3991:
3986:
3981:
3976:
3971:
3966:
3960:
3958:
3954:
3953:
3951:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3864:
3863:
3858:
3848:
3843:
3838:
3833:
3832:
3831:
3826:
3821:
3811:
3806:
3801:
3796:
3791:
3790:
3789:
3784:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3743:
3742:
3737:
3727:
3721:
3716:
3711:
3706:
3697:
3692:
3691:
3690:
3685:
3680:
3670:
3665:
3660:
3655:
3650:
3644:
3642:
3638:
3637:
3635:
3634:
3629:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3508:
3507:
3502:
3492:
3491:
3490:
3485:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3414:
3413:
3408:
3398:
3393:
3388:
3383:
3378:
3373:
3367:
3365:
3361:
3360:
3358:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3308:
3303:
3298:
3293:
3288:
3283:
3282:
3281:
3276:
3271:
3266:
3261:
3256:
3246:
3241:
3236:
3231:
3226:
3221:
3220:
3219:
3214:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3163:
3162:
3157:
3152:
3147:
3142:
3137:
3127:
3126:
3125:
3120:
3115:
3105:
3100:
3099:
3098:
3093:
3088:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3027:
3025:
3021:
3020:
3018:
3017:
3012:
3011:
3010:
3005:
3000:
2995:
2990:
2985:
2975:
2970:
2965:
2960:
2955:
2950:
2945:
2944:
2943:
2938:
2933:
2928:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2872:
2871:
2866:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2785:
2784:
2779:
2769:
2764:
2759:
2754:
2753:
2752:
2747:
2742:
2737:
2727:
2722:
2717:
2716:
2715:
2705:
2700:
2695:
2690:
2685:
2684:
2683:
2678:
2673:
2663:
2658:
2657:
2656:
2651:
2646:
2641:
2636:
2625:
2623:
2619:
2618:
2604:
2602:
2601:
2594:
2587:
2579:
2570:
2569:
2567:
2566:
2560:
2553:
2551:
2545:
2538:
2536:
2530:
2523:
2521:
2515:
2508:
2506:
2500:
2493:
2490:
2487:
2486:
2483:
2481:
2480:
2473:
2466:
2458:
2452:
2451:
2446:
2439:
2438:External links
2436:
2434:
2433:
2407:(5): 400β401.
2393:
2350:
2332:(4): 433β440.
2321:
2303:(3): 785β786.
2292:
2264:(1): 131β140.
2249:
2220:
2200:(2): 330β336.
2185:
2150:
2107:
2081:(3): 569β576.
2069:
2041:(2): 281β285.
2030:
2001:
1958:
1905:
1895:(6): 423β429.
1884:
1855:
1829:(1): 396β400.
1818:
1774:
1772:
1769:
1766:
1765:
1724:
1683:
1648:
1607:
1578:(4): 345β357.
1558:
1509:
1482:(1): 392β395.
1463:
1428:
1401:(3): 542β549.
1384:
1372:
1354:
1336:
1315:
1293:
1292:
1290:
1287:
1274:
1271:
1219:
1216:
1178:
1175:
1171:dendritic cell
1131:Thrombomodulin
1126:
1125:
1122:
1121:
1116:
1106:
1105:
1099:
1098:
1095:
1094:
1092:
1090:
1083:
1082:
1075:
1068:
1064:
1063:
1060:
1059:
1049:
1048:
1042:
1039:
1038:
1028:
1027:
1021:
1017:
1016:
1013:
1012:
1002:
1001:
995:
992:
991:
981:
980:
974:
970:
969:
966:
965:
957:
956:
950:
947:
946:
938:
937:
931:
925:
924:
921:
920:
912:
911:
905:
902:
901:
893:
892:
886:
880:
879:
876:
875:
867:
866:
860:
857:
856:
848:
847:
841:
835:
834:
829:
824:
820:
819:
809:
808:
805:
804:
793:
792:
790:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
733:
731:
727:
726:
724:
723:
718:
713:
708:
703:
698:
693:
688:
682:
680:
676:
675:
673:
672:
667:
662:
657:
651:
649:
645:
644:
634:
633:
630:
629:
626:
625:
617:
616:
598:
592:
591:
588:
587:
579:
578:
575:
574:
572:
571:
567:
563:
559:
555:
551:
547:
543:
542:left lung lobe
539:
535:
531:
528:
527:
516:
513:
512:
510:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
466:
465:
453:
452:
444:
433:
427:
426:
423:RNA expression
415:
414:
411:
410:
402:
398:
397:
389:
386:
381:
375:
374:
365:
358:
352:
348:
347:
342:
336:
335:
327:
326:
314:
313:
310:
309:
301:
297:
296:
288:
285:
280:
274:
273:
264:
257:
251:
247:
246:
239:
233:
232:
224:
223:
211:
210:
167:
163:
162:
154:
146:
145:
141:
140:
137:
136:
133:
132:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4644:
4633:
4630:
4628:
4625:
4623:
4620:
4619:
4617:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4416:
4412:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4212:
4210:
4206:
4200:
4197:
4195:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4139:
4136:
4134:
4131:
4130:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4058:
4055:
4053:
4049:
4046:
4044:
4041:
4037:
4034:
4032:
4029:
4028:
4027:
4024:
4022:
4019:
4015:
4012:
4010:
4007:
4006:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3961:
3959:
3955:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3862:
3859:
3857:
3854:
3853:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3830:
3827:
3825:
3822:
3820:
3817:
3816:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3788:
3785:
3783:
3780:
3779:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3741:
3738:
3736:
3733:
3732:
3731:
3728:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3701:
3698:
3696:
3693:
3689:
3686:
3684:
3681:
3679:
3676:
3675:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3645:
3643:
3639:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3506:
3503:
3501:
3498:
3497:
3496:
3493:
3489:
3486:
3484:
3481:
3480:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3412:
3409:
3407:
3404:
3403:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3368:
3366:
3362:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3251:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3218:
3215:
3213:
3210:
3209:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3132:
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2036:
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2027:
2023:
2019:
2015:
2011:
2007:
2002:
1998:
1994:
1989:
1984:
1980:
1976:
1972:
1968:
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1784:FASEB Journal
1781:
1776:
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1770:
1761:
1757:
1752:
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1739:
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1728:
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1501:
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1432:
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1400:
1396:
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1376:
1373:
1368:
1364:
1358:
1355:
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1346:
1340:
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1333:
1329:
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1322:
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1316:
1312:
1308:
1303:
1301:
1299:
1295:
1288:
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1284:
1280:
1272:
1270:
1268:
1264:
1259:
1257:
1253:
1249:
1244:
1242:
1237:
1236:anticoagulant
1233:
1229:
1225:
1217:
1215:
1213:
1209:
1208:transmembrane
1205:
1201:
1197:
1193:
1189:
1186:
1185:
1176:
1174:
1172:
1168:
1164:
1160:
1156:
1153:. It reduces
1152:
1148:
1144:
1140:
1136:
1132:
1120:
1115:
1111:
1107:
1104:
1100:
1093:
1091:
1088:
1084:
1080:
1076:
1073:
1069:
1065:
1058:
1056:
1050:
1046:
1043:
1037:
1035:
1029:
1025:
1022:
1018:
1011:
1009:
1003:
999:
996:
990:
988:
982:
978:
975:
973:RefSeq (mRNA)
971:
964:
963:
958:
954:
951:
945:
944:
939:
935:
932:
930:
926:
919:
918:
913:
909:
906:
900:
899:
894:
890:
887:
885:
881:
874:
873:
868:
864:
861:
855:
854:
849:
845:
842:
840:
836:
833:
830:
828:
825:
821:
818:
814:
810:
803:
799:
794:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
734:
732:
729:
728:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
683:
681:
678:
677:
671:
668:
666:
663:
661:
658:
656:
653:
652:
650:
647:
646:
643:
642:Gene ontology
639:
635:
623:
618:
614:
607:
602:
599:
597:
593:
585:
580:
569:
565:
561:
557:
553:
550:Gonadal ridge
549:
545:
541:
537:
533:
532:
529:
525:
520:
517:
507:
503:
499:
495:
492:skin of thigh
491:
487:
483:
479:
475:
471:
470:
467:
463:
458:
455:
454:
451:
449:
445:
443:
442:
438:
437:
434:
432:
428:
424:
420:
416:
408:
403:
399:
395:
390:
380:
376:
369:
362:
356:
349:
341:
337:
333:
328:
324:
319:
315:
307:
302:
298:
294:
289:
279:
275:
268:
261:
255:
248:
244:
238:
234:
230:
225:
221:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
164:
159:
152:
147:
142:
131:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4127:
4047:
4025:
4003:
3850:
3813:
3776:
3729:
3699:
3672:
3596:
3494:
3400:
3248:
2977:
2729:
2561:
2546:
2531:
2516:
2501:
2404:
2400:
2362:
2358:
2329:
2325:
2300:
2296:
2261:
2257:
2228:
2225:Biochemistry
2224:
2197:
2193:
2162:
2158:
2119:
2115:
2078:
2074:
2038:
2034:
2009:
2006:Biochemistry
2005:
1970:
1966:
1917:
1913:
1892:
1888:
1863:
1859:
1826:
1822:
1787:
1783:
1741:
1737:
1727:
1700:
1696:
1686:
1661:
1657:
1651:
1624:
1620:
1610:
1575:
1571:
1561:
1526:
1522:
1512:
1479:
1475:
1466:
1441:
1438:Biochemistry
1437:
1431:
1398:
1394:
1387:
1375:
1366:
1357:
1348:
1339:
1276:
1273:Interactions
1260:
1248:glycoprotein
1245:
1221:
1182:
1180:
1134:
1130:
1129:
1052:
1031:
1005:
984:
960:
941:
915:
896:
870:
851:
831:
826:
691:cell surface
558:aortic valve
446:
439:
405:148,250,108
392:148,246,386
166:External IDs
85:
29:
2484:PDB gallery
484:skin of hip
304:23,049,672
291:23,045,633
144:Identifiers
4616:Categories
2612:(see also
2397:Maglott DR
1334:, May 2017
1313:, May 2017
1289:References
737:hemostasis
480:right lung
450:(ortholog)
187:HomoloGene
2043:CiteSeerX
1472:Sadler JE
1232:protein C
1204:Threonine
1055:NP_033404
1034:NP_000352
1008:NM_009378
987:NM_000361
817:Orthologs
538:left lung
476:vena cava
195:GeneCards
2606:Proteins
2429:34951074
2297:Genomics
2103:28744944
1880:15178554
1851:25122238
1814:19565674
1678:12480257
1643:11086035
1602:19625716
1553:31287944
1504:32297505
1330:–
1309:–
1283:thrombin
1279:interact
1258:(aHUS).
1228:thrombin
1224:cofactor
1218:Function
1173:subset.
1167:monocyte
1151:thrombin
1103:Wikidata
796:Sources:
706:membrane
546:calvaria
283:20p11.21
4414:301β350
4208:251β300
4160:CD240CE
3957:201β250
3641:151β200
3364:101β150
2421:8661740
2389:8528067
2380:2143218
2346:8390446
2317:8244401
2288:8216207
2279:1134829
2245:7947766
2216:7811989
2181:7559494
2146:3001144
2095:2839283
2065:2836377
2026:2822087
1997:2820710
1954:2819876
1922:Bibcode
1901:1667949
1843:9198186
1806:7615164
1760:2544585
1719:8663147
1593:3530919
1544:6852297
1496:9198185
1458:2822087
1423:8417511
1415:8943899
1332:Ensembl
1311:Ensembl
1263:antigen
1234:in the
1226:in the
929:UniProt
884:Ensembl
823:Species
802:QuickGO
570:decidua
425:pattern
151:Aliases
4421:CD300A
4380:CDw293
4165:CD240D
4026:CD213a
4004:CDw210
3969:CD202b
3943:CDw199
3938:CDw198
3592:CD140b
3024:51β100
2427:
2419:
2387:
2377:
2344:
2315:
2286:
2276:
2243:
2214:
2179:
2144:
2137:424339
2134:
2101:
2093:
2075:Cancer
2063:
2045:
2024:
1995:
1988:553573
1985:
1952:
1945:299089
1942:
1899:
1878:
1849:
1841:
1812:
1804:
1758:
1717:
1676:
1641:
1600:
1590:
1551:
1541:
1502:
1494:
1456:
1421:
1413:
1200:Serine
1169:and a
1159:enzyme
1089:search
1087:PubMed
962:P15306
943:P07204
839:Entrez
596:BioGPS
175:188040
4601:CD350
4596:CD349
4591:CD344
4586:CD340
4581:CD339
4576:CD338
4571:CD337
4566:CD336
4561:CD335
4556:CD334
4551:CD333
4546:CD332
4541:CD331
4536:CD329
4531:CD328
4526:CD327
4521:CD326
4516:CD325
4511:CD324
4506:CD322
4501:CD321
4496:CD320
4491:CD318
4486:CD317
4481:CD316
4476:CD315
4471:CD314
4466:CD312
4461:CD309
4456:CD307
4451:CD306
4446:CD305
4441:CD304
4436:CD303
4431:CD302
4426:CD301
4405:CD299
4400:CD298
4395:CD297
4390:CD295
4385:CD294
4375:CD292
4370:CD290
4365:CD289
4360:CD288
4355:CD286
4350:CD284
4345:CD283
4340:CD282
4335:CD281
4330:CD280
4325:CD279
4320:CD278
4315:CD276
4310:CD275
4305:CD274
4300:CD273
4295:CD272
4290:CD271
4285:CD269
4280:CD268
4275:CD267
4270:CD266
4265:CD265
4260:CD264
4255:CD263
4250:CD262
4245:CD261
4240:CD258
4235:CD257
4230:CD256
4225:CD254
4220:CD253
4215:CD252
4199:CD249
4194:CD248
4190:CD247
4185:CD246
4180:CD244
4175:CD243
4170:CD241
4155:CD239
4150:CD238
4145:CD236
4128:CD235
4123:CD234
4118:CD233
4113:CD230
4108:CD229
4103:CD228
4098:CD227
4093:CD226
4088:CD225
4083:CD224
4078:CD223
4073:CD222
4068:CD221
4063:CD220
4048:CD218
4043:CD217
4021:CD212
3999:CD209
3994:CD208
3989:CD207
3984:CD206
3979:CD205
3974:CD204
3964:CD201
3948:CD200
3933:CD197
3928:CD196
3923:CD195
3918:CD194
3913:CD193
3908:CD192
3903:CD191
3898:CD186
3893:CD185
3888:CD184
3883:CD183
3878:CD182
3873:CD181
3868:CD180
3851:CD179
3846:CD178
3841:CD177
3836:CD174
3814:CD172
3809:CD171
3804:CD170
3799:CD169
3794:CD168
3777:CD167
3772:CD166
3767:CD164
3762:CD163
3757:CD162
3752:CD161
3747:CD160
3730:CD159
3700:CD158
3695:CD157
3673:CD156
3668:CD155
3663:CD154
3658:CD153
3653:CD152
3648:CD151
3632:CD150
3627:CD148
3622:CD147
3617:CD146
3612:CD144
3607:CD143
3602:CD142
3597:CD141
3587:CD138
3582:CD137
3577:CD136
3572:CD135
3567:CD134
3562:CD133
3557:CD132
3552:CD131
3547:CD130
3542:CD129
3537:CD127
3532:CD126
3527:CD125
3522:CD124
3517:CD123
3512:CD122
3495:CD121
3478:CD120
3473:CD119
3468:CD118
3463:CD117
3458:CD116
3453:CD115
3448:CD114
3443:CD113
3438:CD112
3433:CD111
3428:CD110
3423:CD109
3418:CD108
3401:CD107
3396:CD106
3391:CD105
3386:CD104
3381:CD103
3376:CD102
3371:CD101
3355:CD100
2425:S2CID
2194:Blood
2099:S2CID
1847:S2CID
1810:S2CID
1500:S2CID
1419:S2CID
1281:with
872:21824
832:Mouse
827:Human
798:Amigo
554:ankle
448:Mouse
441:Human
388:Start
323:Mouse
287:Start
220:Human
183:98736
18:CD141
3350:CD99
3345:CD98
3340:CD97
3335:CD96
3330:CD95
3325:CD94
3320:CD93
3315:CD92
3311:CD91
3306:CD90
3301:CD89
3296:CD88
3291:CD87
3286:CD86
3249:CD85
3244:CD84
3239:CD83
3234:CD82
3229:CD81
3224:CD80
3207:CD79
3202:CD78
3197:CD74
3192:CD73
3187:CD72
3182:CD71
3177:CD70
3172:CD69
3167:CD68
3130:CD66
3108:CD64
3103:CD63
3081:CD62
3076:CD61
3071:CD59
3066:CD58
3061:CD57
3056:CD56
3051:CD55
3046:CD54
3041:CD53
3036:CD52
3031:CD51
3015:CD50
2978:CD49
2973:CD48
2968:CD47
2963:CD46
2958:CD45
2953:CD44
2948:CD43
2921:CD42
2916:CD41
2911:CD40
2906:CD39
2901:CD38
2896:CD37
2891:CD36
2886:CD35
2881:CD34
2876:CD33
2859:CD32
2854:CD31
2849:CD30
2844:CD29
2839:CD28
2834:CD27
2829:CD26
2824:CD25
2819:CD24
2814:CD23
2809:CD22
2804:CD21
2799:CD20
2794:CD19
2789:CD18
2772:CD16
2767:CD15
2762:CD14
2757:CD13
2730:CD11
2725:CD10
2622:1β50
2562:2adx
2547:1zaq
2532:1dx5
2517:1dqb
2502:1adx
2417:PMID
2385:PMID
2342:PMID
2313:PMID
2284:PMID
2241:PMID
2212:PMID
2177:PMID
2142:PMID
2091:PMID
2061:PMID
2022:PMID
1993:PMID
1950:PMID
1897:PMID
1876:PMID
1839:PMID
1802:PMID
1756:PMID
1715:PMID
1674:PMID
1639:PMID
1598:PMID
1549:PMID
1492:PMID
1454:PMID
1411:PMID
1261:The
1198:, a
1188:gene
1184:THBD
853:7056
431:Bgee
379:Band
340:Chr.
278:Band
237:Chr.
199:THBD
171:OMIM
158:THBD
128:3GIS
124:2ADX
120:1ZAQ
116:1TMR
112:1HLT
108:1FGE
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