308:
285:
182:
207:
566:
559:
314:
213:
1183:
causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on
61:
1076:
SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin.
1184:
endothelial cells and adherent platelets. This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue.
1203:
PSGL-1 has been shown to bind to VISTA (V-domain Ig suppressor of T cell activation) but this binding only occurs under acidic pH conditions (pH < 6.5) such as can be found in tumor microenvironments (TME).
2094:
Woltmann G, McNulty CA, Dewson G, et al. (2000). "Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow".
1938:"Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques"
1893:"Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat"
3072:
1858:"A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin"
2211:
2126:"Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation"
321:
220:
1499:
3062:
1827:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1782:
Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS (1997). "Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells".
3042:
2179:
2008:"Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin"
789:
770:
143:
3904:
2228:
2204:
3635:
1088:
both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.
3623:
3401:
1175:
and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the
4236:
3687:
3682:
3628:
3408:
2189:
1288:
1270:
4241:
3141:
3067:
2197:
1675:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
4170:
4165:
4160:
4155:
3082:
995:
307:
1519:
1002:
4135:
284:
1306:
3939:
3433:
3119:
2053:"P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo"
1607:"The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine"
1257:
1236:
3578:
3114:
1139:
206:
181:
1322:"Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin"
1253:
58:
4075:
3547:
3542:
3487:
3221:
2670:
1568:
Sako D, Chang XJ, Barone KM, et al. (1993). "Expression cloning of a functional glycoprotein ligand for P-selectin".
1232:
3769:
3492:
123:
3087:
320:
219:
3799:
2224:
1066:
313:
212:
2665:
1973:"Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin"
3849:
2744:
2170:
1453:"PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus"
1130:. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.
834:
131:
1642:"Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand"
3813:
2166:
1363:"Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin"
815:
3156:
3151:
3146:
3136:
2443:
2371:
1127:
1500:
Immune Factor Seen to
Control T-Cell Checkpoints Involved in Spread of Cancers and Infections. June 2016
2500:
2418:
1539:
Furie B, Furie BC (2004). "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation".
195:
3737:
3450:
1791:
1510:
Nature. 2019 Oct;574(7779):565-570. doi: 10.1038/s41586-019-1674-5. Epub 2019 Oct 23. PMID: 31645726
1197:
110:
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955:
904:
4246:
3171:
2905:
1815:
1722:
1705:
1593:
1482:
1433:
1193:
155:
1706:"P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation"
959:
929:
908:
1404:"A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding"
565:
2147:
2112:
2082:
2039:
1994:
1959:
1924:
1879:
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1807:
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2019:
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2007:
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3413:
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2910:
1819:
1180:
1099:
393:
172:
135:
1741:"Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin"
1552:
1437:
159:
4125:
3774:
3552:
3527:
3226:
2848:
2774:
2248:
1293:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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1989:
1972:
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1998:
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17:
1521:
Reviving exhausted T cells to tackle immunotherapy-resistant cancers
4215:
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127:
2193:
574:
3722:
2334:
2322:
2317:
2312:
2302:
2275:
2243:
1080:
The organization of the SELPLG gene closely resembles that of
2124:
Tsuchihashi S, Fondevila C, Shaw GD, et al. (2006).
1126:(leukocyte). Selectins are part of the broader family of
383:
1936:
Wimazal F, Ghannadan M, Müller MR, et al. (2000).
1118:), which is one of a family of selectins that includes
1971:
Epperson TK, Patel KD, McEver RP, Cummings RD (2000).
1640:
Veldman GM, Bean KM, Cumming DA, et al. (1995).
1361:
Wilkins PP, Moore KL, McEver RP, Cummings RD (1995).
548:
2051:
Frenette PS, Denis CV, Weiss L, et al. (2000).
1891:
Bennett EP, Hassan H, Mandel U, et al. (1998).
4028:
3822:
3571:
3255:
2978:
2638:
2236:
1192:In mice it seems to be an immune factor regulating
973:
948:
922:
897:
1704:Guyer DA, Moore KL, Lynam EB, et al. (1996).
1605:Moore KL, Eaton SF, Lyons DE, et al. (1994).
1402:Sako D, Comess KM, Barone KM, et al. (1995).
1249:
1247:
1245:
1228:
1226:
1224:
2006:André P, Spertini O, Guia S, et al. (2000).
1320:Li F, Wilkins PP, Crawley S, et al. (1996).
330:
229:
1856:Snapp KR, Ding H, Atkins K, et al. (1998).
1739:Goetz DJ, Greif DM, Ding H, et al. (1997).
27:Protein-coding gene in the species Homo sapiens
1254:GRCm38: Ensembl release 89: ENSMUSG00000048163
114:, CD162, CLA, PSGL-1, PSGL1, selectin P ligand
2205:
8:
1723:10.1182/blood.V88.7.2415.bloodjournal8872415
1233:GRCh38: Ensembl release 89: ENSG00000110876
2212:
2198:
2190:
2180:United States National Library of Medicine
730:
590:
371:
270:
167:
69:
2229:list of human clusters of differentiation
2169:at the U.S. National Library of Medicine
2141:
2076:
2033:
2023:
1988:
1953:
1918:
1908:
1873:
1764:
1721:
1657:
1622:
1468:
1419:
1378:
1337:
2178:This article incorporates text from the
1142:to gain its selectin binding activity:
1307:"Entrez Gene: SELPLG selectin P ligand"
1220:
1159:tetrasaccharide (sLex) to its O-linked
1196:, and it could be a target for future
29:
1138:PSGL-1 protein requires two distinct
639:integral component of plasma membrane
335:
296:
291:
234:
193:
188:
7:
1207:In mice, PSGL-1 seems to facilitate
1084:and the human platelet glycoprotein
970:
945:
919:
894:
870:
851:
825:
806:
780:
761:
675:cellular response to interleukin-6
553:
471:
409:
388:
25:
1955:10.1034/j.1399-0039.1999.540507.x
2167:P-selectin+glycoprotein+ligand-1
1092:P-selectin glycoprotein ligand-1
564:
557:
449:inferior ganglion of vagus nerve
319:
312:
306:
283:
218:
211:
205:
180:
1140:posttranslational modifications
1134:Posttranslational modification
705:leukocyte tethering or rolling
644:integral component of membrane
575:More reference expression data
537:More reference expression data
1:
1841:10.1016/S0378-1119(97)00411-3
1624:10.1016/S0021-9258(17)31656-3
680:leukocyte adhesive activation
304:
203:
4237:Genes on human chromosome 12
2012:Proc. Natl. Acad. Sci. U.S.A
1689:10.1016/0378-1119(94)90802-8
1582:10.1016/0092-8674(93)90327-M
1553:10.1016/j.molmed.2004.02.008
1541:Trends in Molecular Medicine
1470:10.1016/0092-8674(95)90174-4
1421:10.1016/0092-8674(95)90173-6
4242:Clusters of differentiation
2225:clusters of differentiation
1179:of blood vessels. However,
1171:PSGL-1 is expressed on all
4263:
2143:10.4049/jimmunol.176.1.616
1451:Pouyani T, Seed B (1995).
1067:cluster of differentiation
996:Chr 12: 108.62 – 108.63 Mb
685:viral entry into host cell
608:signaling receptor binding
2109:10.1182/blood.V95.10.3146
1289:"Mouse PubMed Reference:"
1271:"Human PubMed Reference:"
1041:
1036:
1032:
1025:
1009:
1003:Chr 5: 113.96 – 113.97 Mb
990:
977:
952:
941:
926:
901:
890:
877:
873:
858:
854:
845:
832:
828:
813:
809:
800:
787:
783:
768:
764:
755:
740:
733:
729:
713:
593:
589:
572:
556:
547:
534:
483:
474:
421:
412:
382:
374:
370:
353:
340:
303:
282:
273:
269:
252:
239:
202:
179:
170:
166:
121:
118:
108:
101:
96:
77:
72:
55:
50:
45:
41:
37:
32:
2171:Medical Subject Headings
1910:10.1074/jbc.273.46.30472
1659:10.1074/jbc.270.27.16470
1380:10.1074/jbc.270.39.22677
1990:10.1074/jbc.275.11.7839
1875:10.1182/blood.V91.1.154
1128:cell adhesion molecules
618:virus receptor activity
2069:10.1084/jem.191.8.1413
2025:10.1073/pnas.040569797
1339:10.1074/jbc.271.6.3255
499:mesenteric lymph nodes
1757:10.1083/jcb.137.2.509
519:stroma of bone marrow
196:Chromosome 12 (human)
1198:checkpoint inhibitor
1155:the addition of the
1110:cells that binds to
659:plasma membrane raft
298:Chromosome 5 (mouse)
73:List of PDB id codes
46:Available structures
1796:1997Natur.389..978F
1200:anti-cancer drugs.
700:leukocyte migration
337:5 F|5 55.59 cM
2182:, which is in the
1194:T-cell checkpoints
1122:(endothelial) and
835:ENSMUSG00000048163
668:Biological process
627:Cellular component
601:Molecular function
495:tibiofemoral joint
160:SELPLG - orthologs
4224:
4223:
1209:T cell exhaustion
1173:white blood cells
1104:white blood cells
1069:162), is a human
1055:Selectin P ligand
1052:
1051:
1048:
1047:
1021:
1020:
986:
985:
967:
966:
937:
936:
916:
915:
886:
885:
867:
866:
841:
840:
822:
821:
796:
795:
777:
776:
725:
724:
585:
584:
581:
580:
543:
542:
530:
529:
523:entorhinal cortex
468:
467:
461:bone marrow cells
453:periodontal fiber
366:
365:
265:
264:
92:
91:
88:
87:
56:Ortholog search:
16:(Redirected from
4254:
2214:
2207:
2200:
2191:
2155:
2145:
2120:
2090:
2080:
2047:
2037:
2027:
2002:
1992:
1967:
1957:
1932:
1922:
1912:
1903:(46): 30472–81.
1887:
1877:
1852:
1823:
1790:(6654): 978–81.
1778:
1768:
1735:
1725:
1700:
1671:
1661:
1636:
1626:
1617:(37): 23318–27.
1601:
1564:
1525:
1517:
1511:
1508:
1502:
1497:
1491:
1490:
1472:
1448:
1442:
1441:
1423:
1399:
1393:
1392:
1382:
1373:(39): 22677–80.
1358:
1352:
1351:
1341:
1317:
1311:
1310:
1303:
1297:
1296:
1285:
1279:
1278:
1267:
1261:
1251:
1240:
1230:
1057:, also known as
1034:
1033:
1005:
998:
981:
971:
962:
946:
942:RefSeq (protein)
932:
920:
911:
895:
871:
852:
826:
807:
781:
762:
731:
591:
577:
568:
561:
554:
539:
479:
477:Top expressed in
472:
433:mononuclear cell
417:
415:Top expressed in
410:
389:
372:
362:
349:
338:
323:
316:
310:
299:
287:
271:
261:
248:
237:
222:
215:
209:
198:
184:
168:
162:
113:
106:
83:
70:
64:
43:
42:
30:
21:
4262:
4261:
4257:
4256:
4255:
4253:
4252:
4251:
4227:
4226:
4225:
4220:
4024:
3818:
3567:
3251:
2974:
2634:
2232:
2218:
2163:
2158:
2123:
2103:(10): 3146–52.
2093:
2050:
2005:
1983:(11): 7839–53.
1970:
1942:Tissue Antigens
1935:
1890:
1855:
1835:(1–2): 149–56.
1826:
1781:
1738:
1703:
1674:
1652:(27): 16470–5.
1639:
1604:
1567:
1538:
1534:
1532:Further reading
1529:
1528:
1518:
1514:
1509:
1505:
1498:
1494:
1450:
1449:
1445:
1401:
1400:
1396:
1360:
1359:
1355:
1319:
1318:
1314:
1305:
1304:
1300:
1287:
1286:
1282:
1269:
1268:
1264:
1252:
1243:
1231:
1222:
1217:
1190:
1169:
1136:
1043:View/Edit Mouse
1038:View/Edit Human
1001:
994:
991:Location (UCSC)
979:
958:
954:
928:
907:
903:
816:ENSG00000110876
709:
663:
654:plasma membrane
622:
613:protein binding
573:
563:
562:
535:
526:
521:
517:
513:
509:
505:
501:
497:
493:
489:
475:
464:
459:
455:
451:
447:
443:
439:
435:
431:
427:
413:
357:
344:
336:
326:
325:
324:
317:
297:
274:Gene location (
256:
243:
235:
225:
224:
223:
216:
194:
171:Gene location (
122:
109:
102:
79:
57:
28:
23:
22:
15:
12:
11:
5:
4260:
4258:
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3987:
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3259:
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3214:
3209:
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3199:
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3179:
3174:
3169:
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3159:
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2261:
2256:
2251:
2240:
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2202:
2194:
2175:
2174:
2162:
2161:External links
2159:
2157:
2156:
2121:
2091:
2063:(8): 1413–22.
2048:
2003:
1968:
1948:(5): 499–507.
1933:
1888:
1853:
1824:
1779:
1736:
1716:(7): 2415–21.
1701:
1683:(1–2): 171–4.
1672:
1637:
1602:
1576:(6): 1179–86.
1565:
1535:
1533:
1530:
1527:
1526:
1512:
1503:
1492:
1443:
1394:
1353:
1332:(6): 3255–64.
1312:
1298:
1280:
1262:
1241:
1219:
1218:
1216:
1213:
1189:
1186:
1168:
1165:
1164:
1163:
1157:sialyl Lewis x
1153:
1135:
1132:
1114:(P stands for
1050:
1049:
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1029:
1023:
1022:
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1016:
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376:RNA expression
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3398:
3395:
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3388:
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3368:
3365:
3363:
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3356:
3353:
3351:
3348:
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3340:
3337:
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3330:
3327:
3325:
3322:
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3316:
3313:
3311:
3308:
3304:
3301:
3299:
3296:
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3289:
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3284:
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3279:
3276:
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3269:
3266:
3264:
3261:
3260:
3258:
3254:
3248:
3245:
3243:
3240:
3238:
3235:
3233:
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3228:
3225:
3223:
3220:
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3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
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3188:
3185:
3183:
3180:
3178:
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3140:
3138:
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3128:
3125:
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3118:
3116:
3113:
3112:
3111:
3108:
3104:
3101:
3099:
3096:
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3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3027:
3024:
3022:
3019:
3018:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2983:
2981:
2977:
2971:
2968:
2966:
2963:
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2956:
2953:
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2867:
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2857:
2855:
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2845:
2842:
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2833:
2830:
2828:
2825:
2824:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2747:
2746:
2743:
2739:
2736:
2734:
2731:
2729:
2726:
2725:
2724:
2721:
2719:
2716:
2712:
2709:
2707:
2704:
2702:
2699:
2698:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2643:
2641:
2637:
2631:
2628:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2595:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2538:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2485:
2482:
2480:
2477:
2476:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2398:
2395:
2393:
2390:
2389:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2347:
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2343:
2341:
2338:
2336:
2333:
2329:
2326:
2325:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2306:
2304:
2301:
2297:
2294:
2292:
2289:
2287:
2284:
2283:
2282:
2279:
2277:
2274:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2246:
2245:
2242:
2241:
2239:
2235:
2230:
2226:
2222:
2215:
2210:
2208:
2203:
2201:
2196:
2195:
2192:
2188:
2187:
2185:
2184:public domain
2181:
2172:
2168:
2165:
2164:
2160:
2153:
2149:
2144:
2139:
2136:(1): 616–24.
2135:
2131:
2127:
2122:
2118:
2114:
2110:
2106:
2102:
2098:
2092:
2088:
2084:
2079:
2074:
2070:
2066:
2062:
2058:
2054:
2049:
2045:
2041:
2036:
2031:
2026:
2021:
2018:(7): 3400–5.
2017:
2013:
2009:
2004:
2000:
1996:
1991:
1986:
1982:
1978:
1977:J. Biol. Chem
1974:
1969:
1965:
1961:
1956:
1951:
1947:
1943:
1939:
1934:
1930:
1926:
1921:
1916:
1911:
1906:
1902:
1898:
1897:J. Biol. Chem
1894:
1889:
1885:
1881:
1876:
1871:
1868:(1): 154–64.
1867:
1863:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1830:
1825:
1821:
1817:
1813:
1809:
1805:
1804:10.1038/40166
1801:
1797:
1793:
1789:
1785:
1780:
1776:
1772:
1767:
1762:
1758:
1754:
1751:(2): 509–19.
1750:
1746:
1742:
1737:
1733:
1729:
1724:
1719:
1715:
1711:
1707:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1673:
1669:
1665:
1660:
1655:
1651:
1647:
1646:J. Biol. Chem
1643:
1638:
1634:
1630:
1625:
1620:
1616:
1612:
1611:J. Biol. Chem
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1537:
1536:
1531:
1524:
1522:
1516:
1513:
1507:
1504:
1501:
1496:
1493:
1488:
1484:
1480:
1476:
1471:
1466:
1463:(2): 333–43.
1462:
1458:
1454:
1447:
1444:
1439:
1435:
1431:
1427:
1422:
1417:
1414:(2): 323–31.
1413:
1409:
1405:
1398:
1395:
1390:
1386:
1381:
1376:
1372:
1368:
1367:J. Biol. Chem
1364:
1357:
1354:
1349:
1345:
1340:
1335:
1331:
1327:
1326:J. Biol. Chem
1323:
1316:
1313:
1308:
1302:
1299:
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1281:
1276:
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1266:
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1259:
1255:
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1248:
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1234:
1229:
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1221:
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1210:
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1187:
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1166:
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1154:
1152:
1148:
1145:
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1143:
1141:
1133:
1131:
1129:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1097:
1093:
1089:
1087:
1083:
1078:
1074:
1072:
1068:
1064:
1060:
1056:
1044:
1039:
1035:
1031:
1028:
1024:
1017:
1015:
1012:
1008:
1004:
1000:
997:
993:
989:
982:
976:
972:
969:
963:
961:
957:
951:
947:
944:
940:
933:
931:
925:
921:
918:
912:
910:
906:
900:
896:
893:
891:RefSeq (mRNA)
889:
882:
881:
876:
872:
869:
863:
862:
857:
853:
850:
848:
844:
837:
836:
831:
827:
824:
818:
817:
812:
808:
805:
803:
799:
792:
791:
786:
782:
779:
773:
772:
767:
763:
760:
758:
754:
751:
748:
746:
743:
739:
736:
732:
728:
721:
717:
712:
706:
703:
701:
698:
696:
695:cell adhesion
693:
691:
690:viral process
688:
686:
683:
681:
678:
676:
673:
672:
670:
667:
666:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
3742:
3662:
3640:
3618:
3465:
3428:
3391:
3371:
3344:
3314:
3287:
3109:
3015:
2863:
2592:
2344:
2177:
2176:
2133:
2129:
2100:
2096:
2060:
2056:
2015:
2011:
1980:
1976:
1945:
1941:
1900:
1896:
1865:
1861:
1832:
1828:
1787:
1783:
1748:
1745:J. Cell Biol
1744:
1713:
1709:
1680:
1676:
1649:
1645:
1614:
1610:
1573:
1569:
1547:(4): 171–8.
1544:
1540:
1520:
1515:
1506:
1495:
1460:
1456:
1446:
1411:
1407:
1397:
1370:
1366:
1356:
1329:
1325:
1315:
1301:
1292:
1283:
1274:
1265:
1206:
1202:
1191:
1181:inflammation
1170:
1137:
1100:glycoprotein
1095:
1091:
1090:
1079:
1075:
1062:
1058:
1054:
1053:
978:
956:NP_001193538
953:
927:
905:NM_001206609
902:
878:
859:
833:
814:
788:
769:
749:
744:
399:
392:
358:113,970,705
345:113,956,597
257:108,633,894
244:108,621,895
119:External IDs
78:
2057:J. Exp. Med
1920:2066/216411
1211:in tumors.
1177:endothelium
1108:endothelial
515:ankle joint
503:bone marrow
487:granulocyte
425:granulocyte
97:Identifiers
4231:Categories
2227:(see also
1260:, May 2017
1239:, May 2017
1215:References
1124:L-selectin
1120:E-selectin
1112:P-selectin
1086:GpIb-alpha
445:lymph node
403:(ortholog)
140:HomoloGene
4247:Receptors
2130:J Immunol
1188:In cancer
1151:tyrosines
1147:sulfation
1102:found on
960:NP_002997
930:NM_009151
909:NM_003006
735:Orthologs
148:GeneCards
2221:Proteins
2152:16365457
2117:10807781
2087:10770806
2044:10725346
1999:10713099
1964:10599889
1598:23786141
1561:15059608
1487:17480260
1256:–
1235:–
1167:Function
1116:platelet
1027:Wikidata
714:Sources:
649:membrane
457:appendix
437:monocyte
236:12q24.11
4029:301–350
3823:251–300
3775:CD240CE
3572:201–250
3256:151–200
2979:101–150
2078:2193129
1929:9804815
1884:9414280
1849:9373149
1820:4376296
1812:9353122
1792:Bibcode
1775:9128259
1766:2139768
1732:8839831
1697:8125298
1668:7541799
1633:7521878
1590:7505206
1479:7585950
1430:7585949
1389:7559387
1348:8621728
1258:Ensembl
1237:Ensembl
1161:glycans
1098:) is a
847:UniProt
802:Ensembl
741:Species
720:QuickGO
378:pattern
104:Aliases
4036:CD300A
3995:CDw293
3780:CD240D
3641:CD213a
3619:CDw210
3584:CD202b
3558:CDw199
3553:CDw198
3207:CD140b
2639:51–100
2173:(MeSH)
2150:
2115:
2085:
2075:
2042:
2032:
1997:
1962:
1927:
1882:
1847:
1818:
1810:
1784:Nature
1773:
1763:
1730:
1695:
1666:
1631:
1596:
1588:
1559:
1485:
1477:
1436:
1428:
1387:
1346:
1096:PSGL-1
1059:SELPLG
1013:search
1011:PubMed
880:Q62170
861:Q14242
757:Entrez
634:uropod
549:BioGPS
507:spleen
491:thymus
441:spleen
152:SELPLG
136:106689
128:600738
111:SELPLG
33:SELPLG
4216:CD350
4211:CD349
4206:CD344
4201:CD340
4196:CD339
4191:CD338
4186:CD337
4181:CD336
4176:CD335
4171:CD334
4166:CD333
4161:CD332
4156:CD331
4151:CD329
4146:CD328
4141:CD327
4136:CD326
4131:CD325
4126:CD324
4121:CD322
4116:CD321
4111:CD320
4106:CD318
4101:CD317
4096:CD316
4091:CD315
4086:CD314
4081:CD312
4076:CD309
4071:CD307
4066:CD306
4061:CD305
4056:CD304
4051:CD303
4046:CD302
4041:CD301
4020:CD299
4015:CD298
4010:CD297
4005:CD295
4000:CD294
3990:CD292
3985:CD290
3980:CD289
3975:CD288
3970:CD286
3965:CD284
3960:CD283
3955:CD282
3950:CD281
3945:CD280
3940:CD279
3935:CD278
3930:CD276
3925:CD275
3920:CD274
3915:CD273
3910:CD272
3905:CD271
3900:CD269
3895:CD268
3890:CD267
3885:CD266
3880:CD265
3875:CD264
3870:CD263
3865:CD262
3860:CD261
3855:CD258
3850:CD257
3845:CD256
3840:CD254
3835:CD253
3830:CD252
3814:CD249
3809:CD248
3805:CD247
3800:CD246
3795:CD244
3790:CD243
3785:CD241
3770:CD239
3765:CD238
3760:CD236
3743:CD235
3738:CD234
3733:CD233
3728:CD230
3723:CD229
3718:CD228
3713:CD227
3708:CD226
3703:CD225
3698:CD224
3693:CD223
3688:CD222
3683:CD221
3678:CD220
3663:CD218
3658:CD217
3636:CD212
3614:CD209
3609:CD208
3604:CD207
3599:CD206
3594:CD205
3589:CD204
3579:CD201
3563:CD200
3548:CD197
3543:CD196
3538:CD195
3533:CD194
3528:CD193
3523:CD192
3518:CD191
3513:CD186
3508:CD185
3503:CD184
3498:CD183
3493:CD182
3488:CD181
3483:CD180
3466:CD179
3461:CD178
3456:CD177
3451:CD174
3429:CD172
3424:CD171
3419:CD170
3414:CD169
3409:CD168
3392:CD167
3387:CD166
3382:CD164
3377:CD163
3372:CD162
3367:CD161
3362:CD160
3345:CD159
3315:CD158
3310:CD157
3288:CD156
3283:CD155
3278:CD154
3273:CD153
3268:CD152
3263:CD151
3247:CD150
3242:CD148
3237:CD147
3232:CD146
3227:CD144
3222:CD143
3217:CD142
3212:CD141
3202:CD138
3197:CD137
3192:CD136
3187:CD135
3182:CD134
3177:CD133
3172:CD132
3167:CD131
3162:CD130
3157:CD129
3152:CD127
3147:CD126
3142:CD125
3137:CD124
3132:CD123
3127:CD122
3110:CD121
3093:CD120
3088:CD119
3083:CD118
3078:CD117
3073:CD116
3068:CD115
3063:CD114
3058:CD113
3053:CD112
3048:CD111
3043:CD110
3038:CD109
3033:CD108
3016:CD107
3011:CD106
3006:CD105
3001:CD104
2996:CD103
2991:CD102
2986:CD101
2970:CD100
2097:Blood
2035:16251
1862:Blood
1816:S2CID
1710:Blood
1594:S2CID
1483:S2CID
1438:65420
1434:S2CID
1063:CD162
790:20345
750:Mouse
745:Human
716:Amigo
511:blood
429:blood
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
18:CD162
2965:CD99
2960:CD98
2955:CD97
2950:CD96
2945:CD95
2940:CD94
2935:CD93
2930:CD92
2926:CD91
2921:CD90
2916:CD89
2911:CD88
2906:CD87
2901:CD86
2864:CD85
2859:CD84
2854:CD83
2849:CD82
2844:CD81
2839:CD80
2822:CD79
2817:CD78
2812:CD74
2807:CD73
2802:CD72
2797:CD71
2792:CD70
2787:CD69
2782:CD68
2745:CD66
2723:CD64
2718:CD63
2696:CD62
2691:CD61
2686:CD59
2681:CD58
2676:CD57
2671:CD56
2666:CD55
2661:CD54
2656:CD53
2651:CD52
2646:CD51
2630:CD50
2593:CD49
2588:CD48
2583:CD47
2578:CD46
2573:CD45
2568:CD44
2563:CD43
2536:CD42
2531:CD41
2526:CD40
2521:CD39
2516:CD38
2511:CD37
2506:CD36
2501:CD35
2496:CD34
2491:CD33
2474:CD32
2469:CD31
2464:CD30
2459:CD29
2454:CD28
2449:CD27
2444:CD26
2439:CD25
2434:CD24
2429:CD23
2424:CD22
2419:CD21
2414:CD20
2409:CD19
2404:CD18
2387:CD16
2382:CD15
2377:CD14
2372:CD13
2345:CD11
2340:CD10
2237:1–50
2148:PMID
2113:PMID
2083:PMID
2040:PMID
1995:PMID
1960:PMID
1925:PMID
1880:PMID
1845:PMID
1829:Gene
1808:PMID
1771:PMID
1728:PMID
1693:PMID
1677:Gene
1664:PMID
1629:PMID
1586:PMID
1570:Cell
1557:PMID
1523:2023
1475:PMID
1457:Cell
1426:PMID
1408:Cell
1385:PMID
1344:PMID
1106:and
1082:CD43
1071:gene
771:6404
384:Bgee
332:Band
293:Chr.
231:Band
190:Chr.
144:2261
124:OMIM
81:1G1S
62:RCSB
59:PDBe
2335:CD9
2323:CD8
2318:CD7
2313:CD6
2308:CD5
2303:CD4
2281:CD3
2276:CD2
2249:a-c
2244:CD1
2138:doi
2134:176
2105:doi
2073:PMC
2065:doi
2061:191
2030:PMC
2020:doi
1985:doi
1981:275
1950:doi
1915:hdl
1905:doi
1901:273
1870:doi
1837:doi
1833:200
1800:doi
1788:389
1761:PMC
1753:doi
1749:137
1718:doi
1685:doi
1681:138
1654:doi
1650:270
1619:doi
1615:269
1578:doi
1549:doi
1465:doi
1416:doi
1375:doi
1371:270
1334:doi
1330:271
1149:of
1061:or
980:n/a
354:End
253:End
156:OMA
132:MGI
52:PDB
4233::
3807:-
2928:-
2269:1E
2264:1D
2259:1B
2254:1A
2223::
2146:.
2132:.
2128:.
2111:.
2101:95
2099:.
2081:.
2071:.
2059:.
2055:.
2038:.
2028:.
2016:97
2014:.
2010:.
1993:.
1979:.
1975:.
1958:.
1946:54
1944:.
1940:.
1923:.
1913:.
1899:.
1895:.
1878:.
1866:91
1864:.
1860:.
1843:.
1831:.
1814:.
1806:.
1798:.
1786:.
1769:.
1759:.
1747:.
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1726:.
1714:88
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1708:.
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1609:.
1592:.
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1572:.
1555:.
1545:10
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1481:.
1473:.
1461:83
1459:.
1455:.
1432:.
1424:.
1412:83
1410:.
1406:.
1383:.
1369:.
1365:.
1342:.
1328:.
1324:.
1291:.
1273:.
1244:^
1223:^
1073:.
718:/
360:bp
347:bp
259:bp
246:bp
154:;
150::
146:;
142::
138:;
134::
130:;
126::
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3748:a
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3672:b
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3665:(
3651:2
3646:1
3629:b
3624:a
3476:b
3471:a
3444:g
3439:b
3434:a
3402:b
3397:a
3355:c
3350:a
3341:)
3339:k
3334:i
3329:e
3324:d
3319:a
3317:(
3303:c
3298:b
3293:a
3120:b
3115:a
3103:b
3098:a
3026:b
3021:a
2894:k
2889:j
2884:h
2879:e
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2869:a
2832:b
2827:a
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2760:c
2755:b
2750:a
2738:C
2733:B
2728:A
2711:P
2706:L
2701:E
2623:f
2618:e
2613:d
2608:c
2603:b
2598:a
2556:d
2551:c
2546:b
2541:a
2484:B
2479:A
2397:B
2392:A
2365:d
2360:c
2355:b
2350:a
2328:a
2296:ε
2291:δ
2286:γ
2231:)
2213:e
2206:t
2199:v
2186:.
2154:.
2140::
2119:.
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2067::
2046:.
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2001:.
1987::
1966:.
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1931:.
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1851:.
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1391:.
1377::
1350:.
1336::
1309:.
1295:.
1277:.
1094:(
1065:(
278:)
175:)
158::
20:)
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