953:
has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet, the deficiency of other components of preB cell receptor such as CD179b, Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation, differentiation from the proB cell to preB cell stage, 2) allelic exclusion at the Ig heavy chain gene locus, and 3) promotion of Ig light chain gene rearrangements. Thus, preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain.
321:
298:
195:
220:
1667:
572:
40:
327:
226:
1652:
952:
CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it
66:
1048:
Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments".
1263:
Guelpa-Fonlupt V, Tonnelle C, Blaise D, Fougereau M, Fumoux F (January 1994). "Discrete early pro-B and pre-B stages in normal human bone marrow as defined by surface pseudo-light chain expression".
1199:
Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M, Schiff C (October 1994). "The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain".
2581:
1720:
334:
233:
1666:
2571:
1450:"Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering"
2551:
1688:
1115:"The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface"
655:
156:
636:
3413:
1737:
1713:
3144:
1501:
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005).
3132:
2910:
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3196:
3191:
3137:
2917:
1698:
1631:
1030:
1012:
3750:
2650:
2576:
1706:
1158:"Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species"
320:
3679:
3674:
3669:
3664:
2591:
863:
1651:
870:
297:
3644:
2880:
1094:
3448:
2942:
2628:
999:
978:
3087:
2623:
1380:"Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression"
219:
194:
995:
63:
3584:
3056:
3051:
2996:
2730:
2179:
974:
3278:
3001:
136:
2596:
333:
232:
3308:
1733:
1548:"Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation"
941:
326:
225:
2174:
1624:
3358:
2253:
700:
144:
3322:
681:
2665:
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2655:
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1952:
1880:
2009:
1927:
208:
1343:
Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N (March 1997).
3246:
2959:
1617:
1461:
123:
3273:
3092:
821:
774:
2680:
2414:
1415:"The human V-preB promoter is a target for coordinated activation by early B cell factor and E47"
1331:
1288:
1073:
168:
846:
825:
795:
770:
1589:
1569:
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1489:
1436:
1401:
1366:
1323:
1280:
1251:
1216:
1187:
1144:
1065:
116:
56:
1230:"Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines"
3453:
3186:
3107:
2670:
1863:
1789:
1559:
1524:
1514:
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571:
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344:
288:
243:
164:
3513:
2049:
2044:
1967:
388:
127:, IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1
1465:
39:
3298:
2720:
2231:
2034:
1173:
1139:
1114:
1529:
1502:
1484:
1449:
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1816:
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1077:
406:
185:
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1431:
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172:
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1318:
1301:
1035:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1017:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1564:
1547:
1454:
Proceedings of the
National Academy of Sciences of the United States of America
489:
3564:
3288:
2969:
2710:
2586:
2219:
2214:
2209:
2064:
1848:
1345:"One-megabase sequence analysis of the human immunoglobulin lambda gene locus"
305:
202:
152:
1519:
3403:
3398:
3393:
3383:
3378:
3373:
3368:
1675:: Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer
1300:
Bornemann KD, Brewer JW, Perez E, Doerre S, Sita R, Corley RB (March 1997).
600:
549:
427:
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160:
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894:
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726:
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1061:
926:
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667:
93:
89:
85:
17:
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3523:
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3211:
3175:
3166:
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2811:
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2519:
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2402:
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2246:
2241:
2236:
2184:
2169:
2039:
2029:
1992:
1987:
1905:
1900:
878:
622:
3724:
3699:
3619:
3614:
3604:
3594:
3579:
3574:
3569:
3554:
3508:
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3458:
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3428:
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3343:
3338:
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3313:
3303:
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3011:
3006:
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2705:
2700:
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2640:
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2566:
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2534:
2529:
2509:
2504:
2499:
2494:
2448:
2340:
2335:
2154:
2138:
2131:
2126:
2121:
2116:
2111:
2106:
2081:
2059:
2054:
1947:
1873:
1868:
1858:
1503:"A genome annotation-driven approach to cloning the human ORFeome"
1448:
Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002).
3719:
3714:
3704:
3694:
3689:
3684:
3639:
3629:
3589:
3518:
3488:
3483:
3478:
3473:
3468:
3463:
3418:
3388:
3293:
3261:
3256:
3236:
3226:
3221:
3206:
3201:
3102:
3097:
3066:
3046:
3041:
3031:
3026:
2905:
2858:
2818:
2473:
2468:
2463:
2458:
2443:
2434:
2429:
2424:
2409:
2367:
2362:
2352:
2347:
2330:
2325:
2320:
2315:
2310:
2305:
2300:
2295:
2290:
2226:
2199:
2194:
2189:
2164:
2159:
2096:
2091:
2086:
2076:
2071:
2024:
2019:
2014:
2004:
1999:
1982:
1977:
1972:
1962:
1957:
1942:
1937:
1932:
1922:
1917:
1912:
1895:
1890:
1885:
1836:
1804:
1799:
1794:
1777:
1772:
1767:
1762:
933:
140:
1702:
1613:
580:
3231:
1843:
1831:
1826:
1821:
1811:
1784:
1752:
1609:
1588:
Overview of all the structural information available in the
1302:"Secretion of soluble pre-B cell receptors by pre-B cells"
396:
1546:
Rossi B, Espeli M, Schiff C, Gauthier L (July 2006).
561:
3537:
3331:
3080:
2764:
2487:
2147:
1745:
839:
814:
788:
763:
991:
989:
987:
970:
968:
966:
343:
242:
27:Protein-coding gene in the species Homo sapiens
1660:: Crystal structure of the pre-B cell receptor
996:GRCm38: Ensembl release 89: ENSMUSG00000059305
1714:
1625:
1156:Bauer SR, Kudo A, Melchers F (January 1988).
1095:"Entrez Gene: VPREB1 pre-B lymphocyte gene 1"
8:
1378:Fang T, Smith BP, Roman CA (October 2001).
975:GRCh38: Ensembl release 89: ENSG00000169575
936:. VPREB1 has also recently been designated
1721:
1707:
1699:
1689:United States National Library of Medicine
1632:
1618:
1610:
596:
384:
283:
180:
74:
1738:list of human clusters of differentiation
1602:(Human Immunoglobulin iota chain) at the
1563:
1528:
1518:
1483:
1473:
1430:
1395:
1360:
1317:
1245:
1181:
1138:
1687:This article incorporates text from the
1089:
1087:
1647:
1228:Ohnishi K, Takemori T (November 1994).
962:
29:
348:
309:
304:
247:
206:
201:
7:
1413:Gisler R, Sigvardsson M (May 2002).
1119:The Journal of Experimental Medicine
1113:Tsubata T, Reth M (September 1990).
1234:The Journal of Biological Chemistry
1174:10.1002/j.1460-2075.1988.tb02789.x
836:
811:
785:
760:
736:
717:
691:
672:
646:
627:
566:
504:choroid plexus of fourth ventricle
484:
422:
401:
25:
929:that in humans is encoded by the
1665:
1650:
570:
332:
325:
319:
296:
231:
224:
218:
193:
38:
1265:European Journal of Immunology
581:More reference expression data
550:More reference expression data
1:
1247:10.1016/S0021-9258(18)46934-7
317:
216:
3746:Genes on human chromosome 22
1432:10.4049/jimmunol.168.10.5130
1213:10.1016/0161-5890(94)90105-8
3751:Clusters of differentiation
1734:clusters of differentiation
1397:10.4049/jimmunol.167.7.3846
1319:10.4049/jimmunol.158.6.2551
3767:
1565:10.4049/jimmunol.177.2.796
942:cluster of differentiation
1645:
1031:"Mouse PubMed Reference:"
1013:"Human PubMed Reference:"
923:Immunoglobulin iota chain
909:
904:
900:
893:
877:
858:
843:
818:
807:
792:
767:
756:
743:
739:
724:
720:
711:
698:
694:
679:
675:
666:
653:
649:
634:
630:
621:
606:
599:
595:
578:
569:
560:
547:
496:
487:
434:
425:
395:
387:
383:
366:
353:
316:
295:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
82:
77:
60:
55:
50:
46:
37:
32:
1520:10.1186/gb-2004-5-10-r84
871:Chr 16: 16.69 – 16.69 Mb
864:Chr 22: 22.24 – 22.25 Mb
1475:10.1073/pnas.202323999
1277:10.1002/eji.1830240140
350:16 A3|16 10.46 cM
1552:Journal of Immunology
1419:Journal of Immunology
1384:Journal of Immunology
1306:Journal of Immunology
1131:10.1084/jem.172.3.973
311:Chromosome 16 (mouse)
209:Chromosome 22 (human)
1201:Molecular Immunology
78:List of PDB id codes
51:Available structures
1466:2002PNAS...9913014G
1691:, which is in the
1362:10.1101/gr.7.3.250
1062:10.1007/BF00364231
701:ENSMUSG00000059305
173:VPREB1 - orthologs
3733:
3732:
1683:
1682:
920:
919:
916:
915:
889:
888:
854:
853:
833:
832:
803:
802:
782:
781:
752:
751:
733:
732:
707:
706:
688:
687:
662:
661:
643:
642:
591:
590:
587:
586:
556:
555:
543:
542:
481:
480:
446:bone marrow cells
379:
378:
278:
277:
105:
104:
101:
100:
61:Ortholog search:
16:(Redirected from
3758:
1723:
1716:
1709:
1700:
1669:
1654:
1634:
1627:
1620:
1611:
1577:
1567:
1542:
1532:
1522:
1497:
1487:
1477:
1444:
1434:
1409:
1399:
1374:
1364:
1339:
1321:
1296:
1259:
1249:
1240:(45): 28347–53.
1224:
1207:(14): 1099–108.
1195:
1185:
1162:The EMBO Journal
1152:
1142:
1099:
1098:
1091:
1082:
1081:
1045:
1039:
1038:
1027:
1021:
1020:
1009:
1003:
993:
982:
972:
902:
901:
873:
866:
849:
837:
828:
812:
808:RefSeq (protein)
798:
786:
777:
761:
737:
718:
692:
673:
647:
628:
597:
583:
574:
567:
552:
492:
490:Top expressed in
485:
430:
428:Top expressed in
423:
402:
385:
375:
362:
351:
336:
329:
323:
312:
300:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
75:
69:
48:
47:
42:
30:
21:
3766:
3765:
3761:
3760:
3759:
3757:
3756:
3755:
3736:
3735:
3734:
3729:
3533:
3327:
3076:
2760:
2483:
2143:
1741:
1727:
1684:
1679:
1676:
1670:
1661:
1655:
1641:
1638:
1585:
1580:
1545:
1500:
1460:(20): 13014–9.
1447:
1412:
1377:
1349:Genome Research
1342:
1299:
1262:
1227:
1198:
1155:
1112:
1108:
1106:Further reading
1103:
1102:
1093:
1092:
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1047:
1046:
1042:
1029:
1028:
1024:
1011:
1010:
1006:
994:
985:
973:
964:
959:
950:
911:View/Edit Mouse
906:View/Edit Human
869:
862:
859:Location (UCSC)
845:
824:
820:
794:
773:
769:
682:ENSG00000169575
579:
548:
539:
534:
530:
526:
522:
518:
514:
510:
506:
502:
488:
477:
472:
468:
464:
460:
456:
452:
450:trabecular bone
448:
444:
440:
426:
370:
357:
349:
339:
338:
337:
330:
310:
287:Gene location (
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3764:
3762:
3754:
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3722:
3717:
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3707:
3702:
3697:
3692:
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3647:
3642:
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3306:
3301:
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3259:
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3214:
3209:
3204:
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3189:
3184:
3178:
3169:
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3163:
3162:
3157:
3147:
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3141:
3140:
3135:
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3115:
3110:
3105:
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3095:
3090:
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3019:
3014:
3009:
3004:
2999:
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2989:
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2915:
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2898:
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2868:
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2861:
2851:
2845:
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2830:
2821:
2816:
2815:
2814:
2809:
2804:
2794:
2789:
2784:
2779:
2774:
2768:
2766:
2762:
2761:
2759:
2758:
2753:
2748:
2743:
2738:
2733:
2728:
2723:
2718:
2713:
2708:
2703:
2698:
2693:
2688:
2683:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2638:
2633:
2632:
2631:
2626:
2616:
2615:
2614:
2609:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
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2559:
2554:
2549:
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2539:
2538:
2537:
2532:
2522:
2517:
2512:
2507:
2502:
2497:
2491:
2489:
2485:
2484:
2482:
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2476:
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2407:
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2395:
2390:
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2370:
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2360:
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2343:
2338:
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2323:
2318:
2313:
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2298:
2293:
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2276:
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2266:
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2251:
2250:
2249:
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2239:
2229:
2224:
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2222:
2217:
2212:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2151:
2149:
2145:
2144:
2142:
2141:
2136:
2135:
2134:
2129:
2124:
2119:
2114:
2109:
2099:
2094:
2089:
2084:
2079:
2074:
2069:
2068:
2067:
2062:
2057:
2052:
2042:
2037:
2032:
2027:
2022:
2017:
2012:
2007:
2002:
1997:
1996:
1995:
1990:
1980:
1975:
1970:
1965:
1960:
1955:
1950:
1945:
1940:
1935:
1930:
1925:
1920:
1915:
1910:
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1893:
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1871:
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1824:
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1814:
1809:
1808:
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1760:
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1681:
1680:
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1671:
1664:
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1656:
1649:
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1642:
1639:
1637:
1636:
1629:
1622:
1614:
1608:
1607:
1584:
1583:External links
1581:
1579:
1578:
1558:(2): 796–803.
1543:
1507:Genome Biology
1498:
1445:
1425:(10): 5130–8.
1410:
1390:(7): 3846–57.
1375:
1340:
1297:
1260:
1225:
1196:
1153:
1109:
1107:
1104:
1101:
1100:
1083:
1050:Immunogenetics
1040:
1022:
1004:
983:
961:
960:
958:
955:
949:
946:
918:
917:
914:
913:
908:
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890:
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884:
882:
875:
874:
867:
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856:
855:
852:
851:
841:
840:
834:
831:
830:
816:
815:
809:
805:
804:
801:
800:
790:
789:
783:
780:
779:
765:
764:
758:
754:
753:
750:
749:
741:
740:
734:
731:
730:
722:
721:
715:
709:
708:
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689:
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664:
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632:
631:
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619:
618:
613:
608:
604:
603:
593:
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589:
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585:
584:
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564:
558:
557:
554:
553:
545:
544:
541:
540:
538:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
500:choroid plexus
497:
494:
493:
482:
479:
478:
476:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
432:
431:
419:
418:
410:
399:
393:
392:
389:RNA expression
381:
380:
377:
376:
368:
364:
363:
355:
352:
347:
341:
340:
331:
324:
318:
314:
313:
308:
302:
301:
293:
292:
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3763:
3752:
3749:
3747:
3744:
3743:
3741:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
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3681:
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3668:
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3638:
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3626:
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3611:
3608:
3606:
3603:
3601:
3598:
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3593:
3591:
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3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3542:
3540:
3536:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3336:
3334:
3330:
3324:
3321:
3319:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3263:
3260:
3258:
3255:
3254:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3235:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3182:
3179:
3177:
3173:
3170:
3168:
3165:
3161:
3158:
3156:
3153:
3152:
3151:
3148:
3146:
3143:
3139:
3136:
3134:
3131:
3130:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3085:
3083:
3079:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
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3025:
3023:
3020:
3018:
3015:
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3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2986:
2983:
2981:
2978:
2977:
2976:
2973:
2971:
2968:
2966:
2963:
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2899:
2897:
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2879:
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2869:
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2857:
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2836:
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2831:
2829:
2825:
2822:
2820:
2817:
2813:
2810:
2808:
2805:
2803:
2800:
2799:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2769:
2767:
2763:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2734:
2732:
2729:
2727:
2724:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2630:
2627:
2625:
2622:
2621:
2620:
2617:
2613:
2610:
2608:
2605:
2604:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2536:
2533:
2531:
2528:
2527:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2492:
2490:
2486:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2381:
2379:
2376:
2375:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2346:
2342:
2339:
2337:
2334:
2333:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2256:
2255:
2252:
2248:
2245:
2243:
2240:
2238:
2235:
2234:
2233:
2230:
2228:
2225:
2221:
2218:
2216:
2213:
2211:
2208:
2207:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2152:
2150:
2146:
2140:
2137:
2133:
2130:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2104:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2066:
2063:
2061:
2058:
2056:
2053:
2051:
2048:
2047:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1994:
1991:
1989:
1986:
1985:
1984:
1981:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1959:
1956:
1954:
1951:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1919:
1916:
1914:
1911:
1907:
1904:
1902:
1899:
1898:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1856:
1855:
1852:
1850:
1847:
1845:
1842:
1838:
1835:
1834:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1806:
1803:
1801:
1798:
1796:
1793:
1792:
1791:
1788:
1786:
1783:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1755:
1754:
1751:
1750:
1748:
1744:
1739:
1735:
1731:
1724:
1719:
1717:
1712:
1710:
1705:
1704:
1701:
1697:
1696:
1694:
1693:public domain
1690:
1674:
1668:
1663:
1659:
1653:
1648:
1644:
1635:
1630:
1628:
1623:
1621:
1616:
1615:
1612:
1605:
1601:
1600:
1595:
1591:
1587:
1586:
1582:
1575:
1571:
1566:
1561:
1557:
1553:
1549:
1544:
1540:
1536:
1531:
1526:
1521:
1516:
1512:
1508:
1504:
1499:
1495:
1491:
1486:
1481:
1476:
1471:
1467:
1463:
1459:
1455:
1451:
1446:
1442:
1438:
1433:
1428:
1424:
1420:
1416:
1411:
1407:
1403:
1398:
1393:
1389:
1385:
1381:
1376:
1372:
1368:
1363:
1358:
1355:(3): 250–61.
1354:
1350:
1346:
1341:
1337:
1333:
1329:
1325:
1320:
1315:
1312:(6): 2551–7.
1311:
1307:
1303:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1271:(1): 257–64.
1270:
1266:
1261:
1257:
1253:
1248:
1243:
1239:
1235:
1231:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1197:
1193:
1189:
1184:
1179:
1175:
1171:
1167:
1163:
1159:
1154:
1150:
1146:
1141:
1136:
1132:
1128:
1124:
1120:
1116:
1111:
1110:
1105:
1096:
1090:
1088:
1084:
1079:
1075:
1071:
1067:
1063:
1059:
1056:(5): 328–33.
1055:
1051:
1044:
1041:
1036:
1032:
1026:
1023:
1018:
1014:
1008:
1005:
1001:
997:
992:
990:
988:
984:
980:
976:
971:
969:
967:
963:
956:
954:
947:
945:
943:
939:
935:
932:
928:
924:
912:
907:
903:
899:
896:
892:
885:
883:
880:
876:
872:
868:
865:
861:
857:
850:
848:
842:
838:
835:
829:
827:
823:
817:
813:
810:
806:
799:
797:
791:
787:
784:
778:
776:
772:
766:
762:
759:
757:RefSeq (mRNA)
755:
748:
747:
742:
738:
735:
729:
728:
723:
719:
716:
714:
710:
703:
702:
697:
693:
690:
684:
683:
678:
674:
671:
669:
665:
658:
657:
652:
648:
645:
639:
638:
633:
629:
626:
624:
620:
617:
614:
612:
609:
605:
602:
598:
594:
582:
577:
573:
568:
565:
563:
559:
551:
546:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
498:
495:
491:
486:
483:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
436:
433:
429:
424:
421:
420:
417:
415:
411:
409:
408:
404:
403:
400:
398:
394:
390:
386:
382:
374:
369:
365:
361:
356:
346:
342:
335:
328:
322:
315:
307:
303:
299:
294:
290:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3251:
3171:
3149:
3127:
2979:
2974:
2937:
2900:
2853:
2823:
2796:
2618:
2524:
2372:
2101:
1853:
1686:
1685:
1672:
1657:
1597:
1555:
1551:
1510:
1506:
1457:
1453:
1422:
1418:
1387:
1383:
1352:
1348:
1309:
1305:
1268:
1264:
1237:
1233:
1204:
1200:
1168:(1): 111–6.
1165:
1161:
1125:(3): 973–6.
1122:
1118:
1053:
1049:
1043:
1034:
1025:
1016:
1007:
951:
937:
930:
922:
921:
844:
822:NP_001290438
819:
793:
775:NM_001303509
768:
744:
725:
699:
680:
654:
635:
615:
610:
536:human kidney
524:right kidney
412:
405:
132:External IDs
83:
1640:PDB gallery
1513:(10): R84.
520:granulocyte
508:bone marrow
454:granulocyte
442:bone marrow
371:16,688,707
358:16,686,267
270:22,245,515
257:22,244,780
110:Identifiers
3740:Categories
1736:(see also
1002:, May 2017
981:, May 2017
957:References
458:lymph node
416:(ortholog)
153:HomoloGene
847:NP_058678
826:NP_009059
796:NM_016982
771:NM_007128
601:Orthologs
161:GeneCards
1730:Proteins
1574:16818733
1539:15461802
1494:12271131
1441:11994467
1406:11564802
1336:45625474
1293:20176205
998:–
977:–
948:Function
895:Wikidata
474:appendix
438:testicle
249:22q11.22
3538:301–350
3332:251–300
3284:CD240CE
3081:201–250
2765:151–200
2488:101–150
1604:PDBe-KB
1594:UniProt
1462:Bibcode
1371:9074928
1328:9058786
1285:8020565
1256:7961773
1221:7935499
1192:3258819
1149:2117639
1140:2188549
1078:6981867
1070:3139558
1000:Ensembl
979:Ensembl
944:179A).
927:protein
713:UniProt
668:Ensembl
607:Species
391:pattern
117:Aliases
3545:CD300A
3504:CDw293
3289:CD240D
3150:CD213a
3128:CDw210
3093:CD202b
3067:CDw199
3062:CDw198
2716:CD140b
2148:51–100
1599:P12018
1572:
1537:
1530:545604
1527:
1492:
1485:130578
1482:
1439:
1404:
1369:
1334:
1326:
1291:
1283:
1254:
1219:
1190:
1183:454222
1180:
1147:
1137:
1076:
1068:
938:CD179A
931:VPREB1
881:search
879:PubMed
746:P13372
727:P12018
623:Entrez
562:BioGPS
532:thymus
528:morula
516:embryo
512:embryo
462:tonsil
165:VPREB1
141:605141
124:VPREB1
33:VPREB1
18:CD179A
3725:CD350
3720:CD349
3715:CD344
3710:CD340
3705:CD339
3700:CD338
3695:CD337
3690:CD336
3685:CD335
3680:CD334
3675:CD333
3670:CD332
3665:CD331
3660:CD329
3655:CD328
3650:CD327
3645:CD326
3640:CD325
3635:CD324
3630:CD322
3625:CD321
3620:CD320
3615:CD318
3610:CD317
3605:CD316
3600:CD315
3595:CD314
3590:CD312
3585:CD309
3580:CD307
3575:CD306
3570:CD305
3565:CD304
3560:CD303
3555:CD302
3550:CD301
3529:CD299
3524:CD298
3519:CD297
3514:CD295
3509:CD294
3499:CD292
3494:CD290
3489:CD289
3484:CD288
3479:CD286
3474:CD284
3469:CD283
3464:CD282
3459:CD281
3454:CD280
3449:CD279
3444:CD278
3439:CD276
3434:CD275
3429:CD274
3424:CD273
3419:CD272
3414:CD271
3409:CD269
3404:CD268
3399:CD267
3394:CD266
3389:CD265
3384:CD264
3379:CD263
3374:CD262
3369:CD261
3364:CD258
3359:CD257
3354:CD256
3349:CD254
3344:CD253
3339:CD252
3323:CD249
3318:CD248
3314:CD247
3309:CD246
3304:CD244
3299:CD243
3294:CD241
3279:CD239
3274:CD238
3269:CD236
3252:CD235
3247:CD234
3242:CD233
3237:CD230
3232:CD229
3227:CD228
3222:CD227
3217:CD226
3212:CD225
3207:CD224
3202:CD223
3197:CD222
3192:CD221
3187:CD220
3172:CD218
3167:CD217
3145:CD212
3123:CD209
3118:CD208
3113:CD207
3108:CD206
3103:CD205
3098:CD204
3088:CD201
3072:CD200
3057:CD197
3052:CD196
3047:CD195
3042:CD194
3037:CD193
3032:CD192
3027:CD191
3022:CD186
3017:CD185
3012:CD184
3007:CD183
3002:CD182
2997:CD181
2992:CD180
2975:CD179
2970:CD178
2965:CD177
2960:CD174
2938:CD172
2933:CD171
2928:CD170
2923:CD169
2918:CD168
2901:CD167
2896:CD166
2891:CD164
2886:CD163
2881:CD162
2876:CD161
2871:CD160
2854:CD159
2824:CD158
2819:CD157
2797:CD156
2792:CD155
2787:CD154
2782:CD153
2777:CD152
2772:CD151
2756:CD150
2751:CD148
2746:CD147
2741:CD146
2736:CD144
2731:CD143
2726:CD142
2721:CD141
2711:CD138
2706:CD137
2701:CD136
2696:CD135
2691:CD134
2686:CD133
2681:CD132
2676:CD131
2671:CD130
2666:CD129
2661:CD127
2656:CD126
2651:CD125
2646:CD124
2641:CD123
2636:CD122
2619:CD121
2602:CD120
2597:CD119
2592:CD118
2587:CD117
2582:CD116
2577:CD115
2572:CD114
2567:CD113
2562:CD112
2557:CD111
2552:CD110
2547:CD109
2542:CD108
2525:CD107
2520:CD106
2515:CD105
2510:CD104
2505:CD103
2500:CD102
2495:CD101
2479:CD100
1332:S2CID
1289:S2CID
1074:S2CID
925:is a
656:22362
616:Mouse
611:Human
470:cecum
466:blood
414:Mouse
407:Human
354:Start
289:Mouse
253:Start
186:Human
157:84741
149:98936
2474:CD99
2469:CD98
2464:CD97
2459:CD96
2454:CD95
2449:CD94
2444:CD93
2439:CD92
2435:CD91
2430:CD90
2425:CD89
2420:CD88
2415:CD87
2410:CD86
2373:CD85
2368:CD84
2363:CD83
2358:CD82
2353:CD81
2348:CD80
2331:CD79
2326:CD78
2321:CD74
2316:CD73
2311:CD72
2306:CD71
2301:CD70
2296:CD69
2291:CD68
2254:CD66
2232:CD64
2227:CD63
2205:CD62
2200:CD61
2195:CD59
2190:CD58
2185:CD57
2180:CD56
2175:CD55
2170:CD54
2165:CD53
2160:CD52
2155:CD51
2139:CD50
2102:CD49
2097:CD48
2092:CD47
2087:CD46
2082:CD45
2077:CD44
2072:CD43
2045:CD42
2040:CD41
2035:CD40
2030:CD39
2025:CD38
2020:CD37
2015:CD36
2010:CD35
2005:CD34
2000:CD33
1983:CD32
1978:CD31
1973:CD30
1968:CD29
1963:CD28
1958:CD27
1953:CD26
1948:CD25
1943:CD24
1938:CD23
1933:CD22
1928:CD21
1923:CD20
1918:CD19
1913:CD18
1896:CD16
1891:CD15
1886:CD14
1881:CD13
1854:CD11
1849:CD10
1746:1–50
1673:2h3n
1658:2h32
1592:for
1570:PMID
1535:PMID
1490:PMID
1437:PMID
1402:PMID
1367:PMID
1324:PMID
1281:PMID
1252:PMID
1217:PMID
1188:PMID
1145:PMID
1066:PMID
934:gene
637:7441
397:Bgee
345:Band
306:Chr.
244:Band
203:Chr.
137:OMIM
94:3BJ9
90:2H3N
86:2H32
67:RCSB
64:PDBe
1844:CD9
1832:CD8
1827:CD7
1822:CD6
1817:CD5
1812:CD4
1790:CD3
1785:CD2
1758:a-c
1753:CD1
1590:PDB
1560:doi
1556:177
1525:PMC
1515:doi
1480:PMC
1470:doi
1427:doi
1423:168
1392:doi
1388:167
1357:doi
1314:doi
1310:158
1273:doi
1242:doi
1238:269
1209:doi
1178:PMC
1170:doi
1135:PMC
1127:doi
1123:172
1058:doi
367:End
266:End
169:OMA
145:MGI
57:PDB
3742::
3316:-
2437:-
1778:1E
1773:1D
1768:1B
1763:1A
1732::
1596::
1568:.
1554:.
1550:.
1533:.
1523:.
1509:.
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1488:.
1478:.
1468:.
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1452:.
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1421:.
1417:.
1400:.
1386:.
1382:.
1365:.
1351:.
1347:.
1330:.
1322:.
1308:.
1304:.
1287:.
1279:.
1269:24
1267:.
1250:.
1236:.
1232:.
1215:.
1205:31
1203:.
1186:.
1176:.
1164:.
1160:.
1143:.
1133:.
1121:.
1117:.
1086:^
1072:.
1064:.
1054:28
1052:.
1033:.
1015:.
986:^
965:^
373:bp
360:bp
272:bp
259:bp
167:;
163::
159:;
155::
151:;
147::
143:;
139::
92:,
88:,
3262:b
3257:a
3183:)
3181:b
3176:a
3174:(
3160:2
3155:1
3138:b
3133:a
2985:b
2980:a
2953:g
2948:b
2943:a
2911:b
2906:a
2864:c
2859:a
2850:)
2848:k
2843:i
2838:e
2833:d
2828:a
2826:(
2812:c
2807:b
2802:a
2629:b
2624:a
2612:b
2607:a
2535:b
2530:a
2403:k
2398:j
2393:h
2388:e
2383:d
2378:a
2341:b
2336:a
2284:f
2279:e
2274:d
2269:c
2264:b
2259:a
2247:C
2242:B
2237:A
2220:P
2215:L
2210:E
2132:f
2127:e
2122:d
2117:c
2112:b
2107:a
2065:d
2060:c
2055:b
2050:a
1993:B
1988:A
1906:B
1901:A
1874:d
1869:c
1864:b
1859:a
1837:a
1805:ε
1800:δ
1795:γ
1740:)
1722:e
1715:t
1708:v
1695:.
1633:e
1626:t
1619:v
1606:.
1576:.
1562::
1541:.
1517::
1511:5
1496:.
1472::
1464::
1443:.
1429::
1408:.
1394::
1373:.
1359::
1353:7
1338:.
1316::
1295:.
1275::
1258:.
1244::
1223:.
1211::
1194:.
1172::
1166:7
1151:.
1129::
1097:.
1080:.
1060::
1037:.
1019:.
940:(
291:)
188:)
171::
20:)
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