1565:. This virus produces an ortholog of CD200, known as viral OX2 (vOX2), a 55 kDa protein. This gene is expressed on the surface of infected cells during viral replicative state. vOX-2 has an approximately 40% sequence similarity with the human gene for CD200 but shares key residues with CD200 in its binding site for CD200R. Due to its ability to engage CD200R, vOX2 can target host immune cells (T lymphocytes, macrophages, neutrophils, basophils) and inhibit anti-viral activity. Particularly, vOX2 is capable of decreasing production of TNF-α, IFN-γ from macrophages and T lymphocytes and the CD170a-dependent activation of NK cells.
309:
286:
183:
208:
4583:
567:
560:
315:
214:
1605:
cells can thus interact with cells expressing CD200R such as T regulatory cells, tumor-associated dendritic cells, tumor associated macrophages and myeloid derived suppressor cells (MDSC). It was shown that CD200 expressed on tumor cells promotes expansion of MDSCs that are capable of inhibiting anti-tumor immune response. CD200 blockade inhibits tumor growth and decreases number of MDSCs in tumor tissue.
1640:, recombinant humanized monoclonal antibody targeting CD200 was tested in patients with chronic lymphocytic leukemia (CLL) and multiple myeloma as a phase I study. Samalizumab treatments showed a dose-dependent decrease in CD200 expression on CLL cells and decreased frequencies of circulating CD200+ CD4+ T lymphocytes in a majority of CLL patients and in multiple myeloma patients.
36:
1604:
CD200 is overexpressed in cancer cells in a number of human tumors including melanoma, ovarian cancer, some B-cell malignances and small cell lung carcinoma. In the tumor microenvironment CD200 is also expressed in endothelial cells and activated T lymphocytes, B lymhocytes and myeloid cells. These
1485:
function and inhibits lytic function of NK cells. In IFN-γ and TNF-α producing macrophages, CD200-CD200R interaction leads to inhibition of function through Dok2 and RasGAP dependent mechanism. Elevated expression of CD200R on macrophages is associated with alternative activation of macrophages to
1620:
survival. This effect is associated with polarization of cytokine response towards increased production of type-2 cytokines and decreased production of type-1 cytokines. In in vitro experiments, allostimulated cells in the presence of CD200 decreased their cytotoxic function in
62:
1476:
activity, promotes indoleamin-2,3 dioxygenase production in macrophages and triggers regulatory T cell expansion. CD200 on dendritic and lymphoid effector cells modulates the activation threshold of inflammatory response and thus contributes to the maintenance of
3422:
2029:
Gorczynski RM (2002). "Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth".
2561:
2280:
Chen DX, Gorczynski RM (February 2005). "Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function".
2165:
Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, et al. (December 2000). "Down-regulation of the macrophage lineage through interaction with OX2 (CD200)".
1608:
The exact relationship between CD200 and cancer development, as well as its impact on disease prognosis, remains unclear and appears to vary depending on the type of tumor.
322:
221:
1919:
Liu JQ, Hu A, Zhu J, Yu J, Talebian F, Bai XF (2020). "CD200-CD200R Pathway in the
Regulation of Tumor Immune Microenvironment and Immunotherapy". In Birbrair A (ed.).
4624:
3412:
3392:
2529:
1596:
Rat cytomegalovirus also express CD200 ortholog known as e127 protein interacts with CD200R. e127 protein is expressed on the surface of infected cells.
885:
866:
144:
4254:
2578:
2554:
3985:
2393:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
3973:
3751:
4037:
4032:
3978:
3758:
2539:
1936:
1729:
1711:
4648:
4643:
3491:
3417:
2547:
308:
4617:
4520:
4515:
4510:
4505:
3432:
2132:"Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function"
1163:
2487:
1394:. Furthermore, sCD200 is associated with the expansion of myeloid-derived suppressor cells in patients with glioblastoma multiforme.
1170:
285:
4485:
3721:
1772:
4653:
4289:
3783:
3469:
1698:
1677:
1622:
1447:
2093:
McCaughan GW, Clark MJ, Barclay AN (1987). "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein".
4610:
3928:
3464:
1975:"Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200"
1923:. Advances in Experimental Medicine and Biology. Vol. 1223. Cham: Springer International Publishing. pp. 155–165.
1694:
2493:
207:
182:
59:
4425:
3897:
3892:
3837:
3571:
3020:
1673:
1358:
At the transcriptional level, CD200 expression is regulated by C/EBP-β. It was shown that CD200 expression is induced by
4119:
3842:
1317:
124:
1593:
leads to an overexpression of CD200R on M2 macrophages and consequently to the inhibition of innate immunity response.
3437:
2317:
Chen Z, Marsden PA, Gorczynski RM (February 2006). "Cloning and characterization of the human CD200 promoter region".
321:
220:
4149:
2574:
1649:
1226:
314:
213:
3015:
2204:"The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans"
4199:
3094:
2480:
1530:
930:
132:
4163:
1337:
911:
3506:
3501:
3496:
3486:
2793:
2721:
1569:
1439:
1313:
20:
2245:
Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, et al. (September 2003).
2850:
2768:
1363:
4087:
3800:
2174:
1403:
1344:
1333:
196:
2247:"Characterization of the CD200 receptor family in mice and humans and their interactions with CD200"
111:
4114:
3933:
2499:
1617:
1562:
1470:
1309:
1127:
1123:
1119:
1115:
1111:
1097:
1093:
1089:
1085:
1065:
1040:
1036:
1032:
1028:
1024:
1020:
1010:
1006:
998:
994:
1242:. CD200 gene is in human located on chromosome 3 in proximity to genes encoding other B7 proteins
3521:
3255:
2305:
2118:
1589:
1348:
156:
1101:
1061:
1002:
2506:
2457:
2422:
2391:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006).
2379:
2356:
Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (October 2005).
2344:
2297:
2268:
2233:
2190:
2153:
2110:
2081:
2038:
2006:
1952:
1932:
1898:
1838:
1583:
1455:
1414:
sequence. It was shown that CD200tr acts as a competitive inhibitor to the full length CD200.
1352:
1329:
1235:
566:
559:
104:
52:
4594:
2130:
Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000).
4590:
4582:
4294:
4027:
3948:
3511:
2704:
2630:
2447:
2412:
2404:
2369:
2334:
2326:
2289:
2258:
2223:
2215:
2182:
2143:
2102:
2071:
2063:
1996:
1986:
1942:
1924:
1888:
1878:
1828:
1818:
1526:
1478:
1359:
1325:
1257:
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two IgSF
401:
332:
276:
231:
1973:
Mahadevan D, Lanasa MC, Farber C, Pandey M, Whelden M, Faas SJ, et al. (August 2019).
152:
4354:
2890:
2885:
2808:
1502:
1391:
376:
2476:
2178:
4139:
3561:
3072:
2875:
2417:
2392:
2228:
2203:
2001:
1974:
1947:
1893:
1866:
1833:
1806:
1451:
1301:
2293:
2148:
2131:
2076:
2051:
800:
795:
790:
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689:
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669:
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633:
628:
623:
618:
613:
608:
4637:
4109:
3566:
2657:
2533:
2515:
2452:
2435:
2219:
1555:
1534:
1487:
1443:
1379:
595:
2309:
1577:
macrophages a thus inhibits neighboring macrophages expressing CD200R that inhibits
136:
4465:
3773:
3763:
3294:
3260:
2358:"Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200"
1626:
1578:
1473:
1411:
1266:
394:
173:
2186:
2122:
2330:
160:
4475:
4124:
3902:
3877:
3576:
3198:
3124:
2598:
2374:
2357:
2263:
2246:
1928:
1734:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1716:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1637:
1574:
1382:. It was shown that elevated levels of serum sCD200 are associated with adverse
1290:
477:
4405:
4129:
3810:
3551:
3427:
3060:
3055:
3050:
2905:
2689:
1991:
1883:
1506:
1431:
1427:
1407:
1387:
1298:
1265:
CD 200 belongs to the immunoglobulin superfamily, particularly belongs to the
1251:
293:
190:
140:
2067:
1561:
KSHV, also known as human herpesvirus-8 is, essential for the development of
4244:
4239:
4234:
4224:
4219:
4214:
4209:
2050:
Douglas J, Albertson DG, Barclay AN, Davis M, Rabbitts PH (September 1988).
1435:
1286:
830:
537:
415:
360:
347:
259:
246:
148:
2461:
2426:
2383:
2348:
2301:
2272:
2237:
2194:
2157:
2042:
2010:
1956:
1902:
1842:
1261:
domains, transmembrane region and a 19 amino acid long cytoplasmatic domain
771:
positive regulation of protein-glutamine gamma-glutamyltransferase activity
706:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
2114:
2085:
1426:
and leads to immunosuppressive signaling. CD200R is strongly expressed on
1210:
4550:
4450:
4264:
4249:
3452:
3447:
3355:
3045:
1867:"Cancel cancer: The immunotherapeutic potential of CD200/CD200R blockade"
1823:
1747:
1499:
1482:
1462:
1367:
1321:
1258:
1194:
975:
956:
1205:
4500:
4495:
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4390:
4204:
4194:
4021:
4000:
3995:
3963:
3768:
3688:
3683:
3678:
3673:
3668:
3586:
3279:
3119:
3114:
3109:
3104:
3099:
2570:
2520:
2510:
2408:
2202:
Wright GJ, Jones M, Puklavec MJ, Brown MH, Barclay AN (February 2001).
2106:
1481:. Interaction between CD200 and CD200R results in a down-regulation of
1438:
as well as on some subtypes of B lymphocytes and T lymphocytes. In the
1423:
1230:
942:
897:
2339:
1402:
Truncated CD200 (CD200tr) is a truncated version of CD200 produced by
81:
4440:
4400:
4385:
4369:
4364:
4344:
4339:
4274:
4082:
4052:
4016:
4007:
3820:
3788:
3652:
3647:
3617:
3596:
3556:
3516:
3382:
3360:
3319:
3243:
3238:
3233:
3228:
3223:
3218:
3087:
3082:
3077:
3025:
3010:
2880:
2870:
2833:
2828:
2746:
2741:
1522:
1518:
1305:
1294:
1282:
1278:
1178:
852:
1807:"CD200:CD200R Interactions and Their Importance in Immunoregulation"
1533:
release and inhibition of immune cell activation and suppression of
1386:
prognosis in chronic lymphocytic leukemia, glioblastoma multiforme,
1805:
Kotwica-Mojzych K, Jodłowska-Jędrych B, Mojzych M (February 2021).
4565:
4540:
4460:
4455:
4445:
4435:
4420:
4415:
4410:
4395:
4349:
4334:
4299:
4284:
4279:
4269:
4189:
4184:
4179:
4158:
4154:
4144:
4057:
3958:
3953:
3862:
3857:
3852:
3847:
3832:
3825:
3805:
3793:
3736:
3731:
3726:
3716:
3711:
3704:
3642:
3632:
3627:
3622:
3612:
3591:
3581:
3546:
3541:
3536:
3531:
3526:
3481:
3476:
3442:
3407:
3402:
3397:
3387:
3375:
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3345:
3340:
3335:
3289:
3181:
3176:
2995:
2979:
2972:
2967:
2962:
2957:
2952:
2947:
2922:
2900:
2895:
2788:
2714:
2709:
2699:
1551:
1383:
815:
811:
756:
positive regulation of transforming growth factor beta production
4560:
4555:
4545:
4535:
4530:
4525:
4480:
4470:
4430:
4359:
4329:
4324:
4319:
4314:
4309:
4304:
4259:
4229:
4134:
4102:
4097:
4077:
4067:
4062:
4047:
4042:
3943:
3938:
3907:
3887:
3882:
3872:
3867:
3746:
3699:
3659:
3314:
3309:
3304:
3299:
3284:
3275:
3270:
3265:
3250:
3208:
3203:
3193:
3188:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3067:
3040:
3035:
3030:
3005:
3000:
2937:
2932:
2927:
2917:
2912:
2865:
2860:
2855:
2845:
2840:
2823:
2818:
2813:
2803:
2798:
2783:
2778:
2773:
2763:
2758:
2753:
2736:
2731:
2726:
2677:
2645:
2640:
2635:
2618:
2613:
2608:
2603:
1514:
1510:
1461:
CD200-CD200R engagement inhibits T-cell immune response, shifts
1247:
1243:
1239:
128:
35:
2543:
716:
homophilic cell adhesion via plasma membrane adhesion molecules
575:
4072:
2684:
2672:
2667:
2662:
2652:
2625:
2593:
1466:
741:
negative regulation of NF-kappaB transcription factor activity
2505:
Overview of all the structural information available in the
1554:
infecting animals as well as human, for example some human
629:
protein binding involved in heterotypic cell-cell adhesion
746:
positive regulation of CREB transcription factor activity
1304:. Moreover CD200 is expressed on various types of human
791:
negative regulation of matrix metallopeptidase secretion
384:
4598:
2052:"RFLP and mapping of human MOX-1 gene on chromosome 3"
1800:
1798:
1796:
1794:
1792:
1790:
1788:
1786:
1784:
1782:
1550:
CD200-encoding gene has been acquired by a number of
549:
736:
negative regulation of cell population proliferation
4378:
4172:
3921:
3605:
3328:
2988:
2586:
1141:
1084:
1054:
993:
2519:(Mouse OX-2 membrane glycoprotein (CD200)) at the
1690:
1688:
1686:
1669:
1667:
1665:
1616:It was shown that in animal models CD200 prolongs
1509:. This leads to a recruitment of adaptor proteins
2031:Archivum Immunologiae et Therapiae Experimentalis
1968:
1966:
1277:CD200 is expressed on dendritic cells, activated
781:negative regulation of neuroinflammatory response
331:
230:
1446:, particularly in tumor-associate macrophages,
115:, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
16:Protein-coding gene in the species Homo sapiens
1695:GRCm38: Ensembl release 89: ENSMUSG00000022661
4618:
2555:
2436:"CD 200-mediated regulation of skin immunity"
8:
1581:production during infection. Infection with
1529:. This signaling leads to the inhibition of
721:negative regulation of macrophage activation
1860:
1858:
1856:
1854:
1852:
1811:International Journal of Molecular Sciences
1674:GRCh38: Ensembl release 89: ENSG00000091972
1498:The engagement of CD200 to CD200R leads to
796:negative regulation of macrophage migration
731:negative regulation of leukocyte activation
4625:
4611:
2562:
2548:
2540:
2530:United States National Library of Medicine
1914:
1912:
1406:mechanism. CD200tr lacks approximately 30
1081:
990:
826:
591:
372:
271:
168:
70:
2579:list of human clusters of differentiation
2479:at the U.S. National Library of Medicine
2451:
2416:
2373:
2338:
2262:
2227:
2147:
2075:
2000:
1990:
1946:
1892:
1882:
1832:
1822:
2528:This article incorporates text from the
2440:The Journal of Investigative Dermatology
1767:
1765:
1442:CD200R is expressed on tumor-associated
776:regulation of neuroinflammatory response
766:positive regulation of arginase activity
1661:
1347:cells CD200 expression is induced upon
801:negative regulation of T cell migration
508:paraventricular nucleus of hypothalamus
25:
1378:Soluble CD200 (sCD200) is present in
655:integral component of plasma membrane
336:
297:
292:
235:
194:
189:
7:
4579:
4577:
1546:Pathogens modulate CD200-CD200R axis
1979:Journal for Immunotherapy of Cancer
1773:"Entrez Gene: CD200 CD200 molecule"
1573:induces expression of CD200 in the
1370:, STAT1 and IRF-1 dependent manner
786:negative regulation of neuron death
634:glycosylated region protein binding
4597:. You can help Knowledge (XXG) by
1422:CD200 interacts with its receptor
1138:
1051:
966:
947:
921:
902:
876:
857:
554:
472:
410:
389:
14:
2294:10.1097/01.TP.0000149506.61000.86
619:protein homodimerization activity
4581:
2453:10.1111/j.0022-202X.2005.23978.x
2220:10.1046/j.1365-2567.2001.01163.x
1521:to DOK-1 and the recruitment of
1448:myeloid-derived suppressor cells
565:
558:
500:dorsomedial hypothalamic nucleus
320:
313:
307:
284:
219:
212:
206:
181:
34:
1525:which negatively regulates the
751:heterotypic cell-cell adhesion
650:integral component of membrane
624:cell adhesion molecule binding
576:More reference expression data
538:More reference expression data
1:
2187:10.1126/science.290.5497.1768
2149:10.1016/S1074-7613(00)00023-6
726:regulation of immune response
492:tunica media of zone of aorta
305:
204:
2331:10.1016/j.molimm.2005.04.014
1318:chronic lymphocytic leukemia
4649:Clusters of differentiation
4644:Genes on human chromosome 3
2575:clusters of differentiation
2375:10.4049/jimmunol.175.7.4441
2264:10.4049/jimmunol.171.6.3034
1929:10.1007/978-3-030-35582-1_8
1250:. In mice CD200 gene is on
4670:
4576:
2498:gene details page in the
2434:Matsue H (December 2005).
1650:Cluster of differentiation
1527:MAPK/ERK signaling pathway
1227:Cluster of Differentiation
1223:OX-2 membrane glycoprotein
609:signaling receptor binding
18:
1992:10.1186/s40425-019-0710-1
1884:10.3389/fonc.2023.1088038
1730:"Mouse PubMed Reference:"
1712:"Human PubMed Reference:"
1590:Trypanosoma brucei brucei
1517:that promotes binding of
1505:on CD200R cytomplasmatic
1209:
1204:
1200:
1193:
1177:
1164:Chr 3: 112.33 – 112.36 Mb
1158:
1145:
1108:
1077:
1058:
1017:
986:
973:
969:
954:
950:
941:
928:
924:
909:
905:
896:
883:
879:
864:
860:
851:
836:
829:
825:
809:
594:
590:
573:
557:
548:
535:
484:
475:
422:
413:
383:
375:
371:
354:
341:
304:
283:
274:
270:
253:
240:
203:
180:
171:
167:
122:
119:
109:
102:
97:
78:
73:
56:
51:
46:
42:
33:
28:
2481:Medical Subject Headings
1531:proinflammatory cytokine
1456:regulatory T lymphocytes
1865:Choe D, Choi D (2023).
1535:mast cell degranulation
1338:glioblastoma multiforme
1171:Chr 16: 45.2 – 45.23 Mb
512:suprachiasmatic nucleus
4654:Membrane protein stubs
4593:–related article is a
2068:10.1093/nar/16.18.9067
2056:Nucleic Acids Research
1921:Tumor Microenvironment
1629:dependent mechanism.
1570:Leishmania amazonensis
1440:tumor microenvironment
1336:, colon carcinoma and
1314:acute myeloid leukemia
496:ventral tegmental area
338:16 B5|16 29.53 cM
21:CD200 (disambiguation)
2362:Journal of Immunology
2251:Journal of Immunology
1871:Frontiers in Oncology
1748:"P41217 (OX2G_HUMAN)"
1541:Clinical significance
299:Chromosome 16 (mouse)
2492:genome location and
2319:Molecular Immunology
1824:10.3390/ijms22041602
1404:alternative splicing
1225:, also named CD200 (
504:ventromedial nucleus
446:orbitofrontal cortex
438:middle frontal gyrus
197:Chromosome 3 (human)
74:List of PDB id codes
47:Available structures
19:For other uses, see
2500:UCSC Genome Browser
2179:2000Sci...290.1768H
2173:(5497): 1768–1771.
1494:Mechanism of action
1450:, tumor-associated
1310:hairy cell leukemia
430:ganglionic eminence
2532:, which is in the
2409:10.1101/gr.4039406
2107:10.1007/BF00404426
1612:In transplantation
1267:B7 receptor family
931:ENSMUSG00000022661
761:cell-cell adhesion
699:Biological process
685:neuronal cell body
643:Cellular component
602:Molecular function
4606:
4605:
4574:
4573:
1938:978-3-030-35581-4
1584:Taenia crassiceps
1467:Th2 type response
1330:testicular cancer
1291:endothelial cells
1229:200) is a human
1220:
1219:
1216:
1215:
1189:
1188:
1154:
1153:
1135:
1134:
1073:
1072:
1048:
1047:
982:
981:
963:
962:
937:
936:
918:
917:
892:
891:
873:
872:
821:
820:
680:neuron projection
586:
585:
582:
581:
544:
543:
531:
530:
469:
468:
367:
366:
266:
265:
161:CD200 - orthologs
93:
92:
89:
88:
57:Ortholog search:
4661:
4627:
4620:
4613:
4591:membrane protein
4585:
4578:
2564:
2557:
2550:
2541:
2465:
2455:
2430:
2420:
2387:
2377:
2368:(7): 4441–4449.
2352:
2342:
2313:
2276:
2266:
2257:(6): 3034–3046.
2241:
2231:
2198:
2161:
2151:
2126:
2089:
2079:
2046:
2015:
2014:
2004:
1994:
1970:
1961:
1960:
1950:
1916:
1907:
1906:
1896:
1886:
1862:
1847:
1846:
1836:
1826:
1802:
1777:
1776:
1769:
1760:
1759:
1757:
1755:
1744:
1738:
1737:
1726:
1720:
1719:
1708:
1702:
1692:
1681:
1671:
1633:As a drug target
1465:profile towards
1326:multiple myeloma
1308:cells including
1202:
1201:
1173:
1166:
1149:
1139:
1130:
1082:
1078:RefSeq (protein)
1068:
1052:
1043:
991:
967:
948:
922:
903:
877:
858:
827:
711:cell recognition
592:
578:
569:
562:
555:
540:
480:
478:Top expressed in
473:
462:Brodmann area 23
458:Brodmann area 46
434:Brodmann area 10
418:
416:Top expressed in
411:
390:
373:
363:
350:
339:
324:
317:
311:
300:
288:
272:
262:
249:
238:
223:
216:
210:
199:
185:
169:
163:
114:
107:
84:
71:
65:
44:
43:
38:
26:
4669:
4668:
4664:
4663:
4662:
4660:
4659:
4658:
4634:
4633:
4632:
4631:
4575:
4570:
4374:
4168:
3917:
3601:
3324:
2984:
2582:
2568:
2473:
2468:
2433:
2397:Genome Research
2390:
2355:
2316:
2282:Transplantation
2279:
2244:
2201:
2164:
2129:
2092:
2049:
2028:
2024:
2022:Further reading
2019:
2018:
1972:
1971:
1964:
1939:
1918:
1917:
1910:
1864:
1863:
1850:
1804:
1803:
1780:
1771:
1770:
1763:
1753:
1751:
1746:
1745:
1741:
1728:
1727:
1723:
1710:
1709:
1705:
1693:
1684:
1672:
1663:
1658:
1646:
1635:
1614:
1602:
1548:
1543:
1503:phosphorylation
1496:
1452:dendritic cells
1420:
1400:
1392:medulloblastoma
1376:
1345:innate immunity
1334:renal carcinoma
1275:
1233:encoded by the
1211:View/Edit Mouse
1206:View/Edit Human
1169:
1162:
1159:Location (UCSC)
1147:
1126:
1122:
1118:
1114:
1110:
1104:
1100:
1096:
1092:
1088:
1064:
1060:
1039:
1035:
1031:
1027:
1023:
1019:
1013:
1009:
1005:
1001:
997:
912:ENSG00000091972
805:
694:
665:plasma membrane
638:
614:protein binding
574:
564:
563:
536:
527:
522:
520:arcuate nucleus
518:
514:
510:
506:
502:
498:
494:
490:
488:ascending aorta
476:
465:
460:
456:
454:parietal pleura
452:
450:Brodmann area 9
448:
444:
440:
436:
432:
428:
414:
358:
345:
337:
327:
326:
325:
318:
298:
275:Gene location (
257:
244:
236:
226:
225:
224:
217:
195:
172:Gene location (
123:
110:
103:
80:
58:
24:
17:
12:
11:
5:
4667:
4665:
4657:
4656:
4651:
4646:
4636:
4635:
4630:
4629:
4622:
4615:
4607:
4604:
4603:
4586:
4572:
4571:
4569:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4382:
4380:
4376:
4375:
4373:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4187:
4182:
4176:
4174:
4170:
4169:
4167:
4166:
4161:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4106:
4105:
4100:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4019:
4010:
4005:
4004:
4003:
3998:
3988:
3983:
3982:
3981:
3976:
3966:
3961:
3956:
3951:
3946:
3941:
3936:
3931:
3925:
3923:
3919:
3918:
3916:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3829:
3828:
3823:
3813:
3808:
3803:
3798:
3797:
3796:
3791:
3786:
3776:
3771:
3766:
3761:
3756:
3755:
3754:
3749:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3708:
3707:
3702:
3692:
3686:
3681:
3676:
3671:
3662:
3657:
3656:
3655:
3650:
3645:
3635:
3630:
3625:
3620:
3615:
3609:
3607:
3603:
3602:
3600:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3473:
3472:
3467:
3457:
3456:
3455:
3450:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3379:
3378:
3373:
3363:
3358:
3353:
3348:
3343:
3338:
3332:
3330:
3326:
3325:
3323:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3273:
3268:
3263:
3258:
3253:
3248:
3247:
3246:
3241:
3236:
3231:
3226:
3221:
3211:
3206:
3201:
3196:
3191:
3186:
3185:
3184:
3179:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3128:
3127:
3122:
3117:
3112:
3107:
3102:
3092:
3091:
3090:
3085:
3080:
3070:
3065:
3064:
3063:
3058:
3053:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2992:
2990:
2986:
2985:
2983:
2982:
2977:
2976:
2975:
2970:
2965:
2960:
2955:
2950:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2909:
2908:
2903:
2898:
2893:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2837:
2836:
2831:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2750:
2749:
2744:
2734:
2729:
2724:
2719:
2718:
2717:
2712:
2707:
2702:
2692:
2687:
2682:
2681:
2680:
2670:
2665:
2660:
2655:
2650:
2649:
2648:
2643:
2638:
2628:
2623:
2622:
2621:
2616:
2611:
2606:
2601:
2590:
2588:
2584:
2583:
2569:
2567:
2566:
2559:
2552:
2544:
2525:
2524:
2503:
2484:
2472:
2471:External links
2469:
2467:
2466:
2431:
2388:
2353:
2325:(6): 579–587.
2314:
2288:(3): 282–288.
2277:
2242:
2214:(2): 173–179.
2199:
2162:
2142:(2): 233–242.
2127:
2101:(5): 329–335.
2095:Immunogenetics
2090:
2047:
2037:(4): 303–309.
2025:
2023:
2020:
2017:
2016:
1962:
1937:
1908:
1848:
1778:
1761:
1739:
1721:
1703:
1682:
1660:
1659:
1657:
1654:
1653:
1652:
1645:
1642:
1634:
1631:
1613:
1610:
1601:
1598:
1563:Kaposi sarcoma
1547:
1544:
1542:
1539:
1495:
1492:
1479:self-tolerance
1419:
1416:
1399:
1398:Truncated form
1396:
1375:
1372:
1274:
1271:
1259:immunoglobulin
1218:
1217:
1214:
1213:
1208:
1198:
1197:
1191:
1190:
1187:
1186:
1184:
1182:
1175:
1174:
1167:
1160:
1156:
1155:
1152:
1151:
1143:
1142:
1136:
1133:
1132:
1106:
1105:
1079:
1075:
1074:
1071:
1070:
1056:
1055:
1049:
1046:
1045:
1015:
1014:
988:
984:
983:
980:
979:
971:
970:
964:
961:
960:
952:
951:
945:
939:
938:
935:
934:
926:
925:
919:
916:
915:
907:
906:
900:
894:
893:
890:
889:
881:
880:
874:
871:
870:
862:
861:
855:
849:
848:
843:
838:
834:
833:
823:
822:
819:
818:
807:
806:
804:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
702:
700:
696:
695:
693:
692:
687:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
552:
546:
545:
542:
541:
533:
532:
529:
528:
526:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
482:
481:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
407:
406:
398:
387:
381:
380:
377:RNA expression
369:
368:
365:
364:
356:
352:
351:
343:
340:
335:
329:
328:
319:
312:
306:
302:
301:
296:
290:
289:
281:
280:
268:
267:
264:
263:
255:
251:
250:
242:
239:
234:
228:
227:
218:
211:
205:
201:
200:
193:
187:
186:
178:
177:
165:
164:
121:
117:
116:
108:
100:
99:
95:
94:
91:
90:
87:
86:
76:
75:
67:
66:
55:
49:
48:
40:
39:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
4666:
4655:
4652:
4650:
4647:
4645:
4642:
4641:
4639:
4628:
4623:
4621:
4616:
4614:
4609:
4608:
4602:
4600:
4596:
4592:
4587:
4584:
4580:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4383:
4381:
4377:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4177:
4175:
4171:
4165:
4162:
4160:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4104:
4101:
4099:
4096:
4095:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4023:
4020:
4018:
4014:
4011:
4009:
4006:
4002:
3999:
3997:
3994:
3993:
3992:
3989:
3987:
3984:
3980:
3977:
3975:
3972:
3971:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3926:
3924:
3920:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3827:
3824:
3822:
3819:
3818:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3795:
3792:
3790:
3787:
3785:
3782:
3781:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3753:
3750:
3748:
3745:
3744:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3706:
3703:
3701:
3698:
3697:
3696:
3693:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3666:
3663:
3661:
3658:
3654:
3651:
3649:
3646:
3644:
3641:
3640:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3610:
3608:
3604:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3471:
3468:
3466:
3463:
3462:
3461:
3458:
3454:
3451:
3449:
3446:
3445:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3377:
3374:
3372:
3369:
3368:
3367:
3364:
3362:
3359:
3357:
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2534:public domain
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2512:
2508:
2504:
2501:
2497:
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2477:CD200+Antigen
2475:
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2012:
2008:
2003:
1998:
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1988:
1984:
1980:
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1958:
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1556:herpesviruses
1553:
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1444:myeloid cells
1441:
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1323:
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1315:
1311:
1307:
1303:
1300:
1296:
1292:
1288:
1284:
1283:T lymphocytes
1280:
1279:B lymphocytes
1272:
1270:
1268:
1264:
1260:
1255:
1253:
1249:
1245:
1241:
1238:
1237:
1232:
1228:
1224:
1212:
1207:
1203:
1199:
1196:
1192:
1185:
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1161:
1157:
1150:
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1080:
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1063:
1057:
1053:
1050:
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1042:
1038:
1034:
1030:
1026:
1022:
1016:
1012:
1008:
1004:
1000:
996:
992:
989:
987:RefSeq (mRNA)
985:
978:
977:
972:
968:
965:
959:
958:
953:
949:
946:
944:
940:
933:
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927:
923:
920:
914:
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904:
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630:
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620:
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612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
561:
556:
553:
551:
547:
539:
534:
523:
519:
516:body of femur
515:
511:
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487:
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142:
138:
134:
130:
126:
118:
113:
106:
101:
96:
85:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
4599:expanding it
4588:
4092:
4012:
3990:
3968:
3912:
3815:
3778:
3741:
3694:
3664:
3637:
3459:
3365:
3213:
2942:
2694:
2527:
2526:
2514:
2494:
2488:
2443:
2439:
2403:(1): 55–65.
2400:
2396:
2365:
2361:
2322:
2318:
2285:
2281:
2254:
2250:
2211:
2207:
2170:
2166:
2139:
2135:
2098:
2094:
2062:(18): 9067.
2059:
2055:
2034:
2030:
1982:
1978:
1920:
1874:
1870:
1814:
1810:
1752:. Retrieved
1742:
1733:
1724:
1715:
1706:
1636:
1615:
1607:
1603:
1595:
1588:
1582:
1568:
1567:
1560:
1549:
1497:
1488:M2 phenotype
1469:, decreases
1460:
1454:and also in
1421:
1412:NH2-terminal
1401:
1377:
1374:Soluble form
1357:
1355:activation.
1342:
1320:, malignant
1281:, activated
1276:
1262:
1256:
1234:
1222:
1221:
1146:
1128:NP_001352784
1124:NP_001352783
1120:NP_001352782
1116:NP_001352781
1112:NP_001352780
1109:
1098:NP_001305759
1094:NP_001305757
1090:NP_001305755
1086:NP_001004196
1066:NM_001358443
1059:
1041:NM_001365855
1037:NM_001365854
1033:NM_001365853
1029:NM_001365852
1025:NM_001365851
1021:NM_001318830
1018:
1011:NM_001318828
1007:NM_001318826
999:NM_001004197
995:NM_001004196
974:
955:
929:
910:
884:
865:
845:
840:
670:cell surface
524:aortic valve
442:hypothalamus
426:frontal pole
400:
393:
258:112,362,812
245:112,332,347
120:External IDs
79:
2446:(6): x–xi.
1877:: 1088038.
1817:(4): 1602.
1638:Samalizumab
1575:bone marrow
1432:neutrophils
1428:macrophages
1408:amino acids
359:45,229,416
346:45,202,498
98:Identifiers
4638:Categories
2577:(see also
2340:1807/16344
2208:Immunology
1985:(1): 227.
1701:, May 2017
1680:, May 2017
1656:References
1507:PTB domain
1436:mast cells
1388:ependymoma
1302:precursors
1299:osteoblast
1287:thymocytes
1273:Expression
1252:chromosome
404:(ortholog)
141:HomoloGene
1750:. Uniprot
1618:allograft
1600:In cancer
1483:basophils
1474:cytotoxic
1368:NF-kappaB
1102:NP_005935
1062:NM_010818
1003:NM_005944
831:Orthologs
690:cell body
149:GeneCards
2571:Proteins
2462:16354172
2427:16344560
2384:16177086
2349:15955564
2310:19242441
2302:15699757
2273:12960329
2238:11260322
2195:11099416
2158:10981966
2136:Immunity
2043:11726033
2011:31443741
1957:32030689
1903:36756156
1843:33562512
1697:–
1676:–
1644:See also
1500:tyrosine
1463:cytokine
1418:Function
1322:melanoma
1195:Wikidata
810:Sources:
660:membrane
4379:301–350
4173:251–300
4125:CD240CE
3922:201–250
3606:151–200
3329:101–150
2521:PDBe-KB
2511:UniProt
2418:1356129
2229:1783166
2175:Bibcode
2167:Science
2115:3032785
2086:2902568
2002:6708181
1948:7339106
1894:9900175
1834:7915401
1699:Ensembl
1678:Ensembl
1552:viruses
1471:NK cell
1410:in the
1295:neurons
1231:protein
943:UniProt
898:Ensembl
837:Species
816:QuickGO
379:pattern
137:1196990
105:Aliases
4386:CD300A
4345:CDw293
4130:CD240D
3991:CD213a
3969:CDw210
3934:CD202b
3908:CDw199
3903:CDw198
3557:CD140b
2989:51–100
2516:O54901
2486:Human
2483:(MeSH)
2460:
2425:
2415:
2382:
2347:
2308:
2300:
2271:
2236:
2226:
2193:
2156:
2123:500342
2121:
2113:
2084:
2077:338677
2074:
2041:
2009:
1999:
1955:
1945:
1935:
1901:
1891:
1841:
1831:
1754:16 May
1523:RasGAP
1424:CD200R
1306:cancer
1181:search
1179:PubMed
976:O54901
957:P41217
853:Entrez
550:BioGPS
237:3q13.2
129:155970
4589:This
4566:CD350
4561:CD349
4556:CD344
4551:CD340
4546:CD339
4541:CD338
4536:CD337
4531:CD336
4526:CD335
4521:CD334
4516:CD333
4511:CD332
4506:CD331
4501:CD329
4496:CD328
4491:CD327
4486:CD326
4481:CD325
4476:CD324
4471:CD322
4466:CD321
4461:CD320
4456:CD318
4451:CD317
4446:CD316
4441:CD315
4436:CD314
4431:CD312
4426:CD309
4421:CD307
4416:CD306
4411:CD305
4406:CD304
4401:CD303
4396:CD302
4391:CD301
4370:CD299
4365:CD298
4360:CD297
4355:CD295
4350:CD294
4340:CD292
4335:CD290
4330:CD289
4325:CD288
4320:CD286
4315:CD284
4310:CD283
4305:CD282
4300:CD281
4295:CD280
4290:CD279
4285:CD278
4280:CD276
4275:CD275
4270:CD274
4265:CD273
4260:CD272
4255:CD271
4250:CD269
4245:CD268
4240:CD267
4235:CD266
4230:CD265
4225:CD264
4220:CD263
4215:CD262
4210:CD261
4205:CD258
4200:CD257
4195:CD256
4190:CD254
4185:CD253
4180:CD252
4164:CD249
4159:CD248
4155:CD247
4150:CD246
4145:CD244
4140:CD243
4135:CD241
4120:CD239
4115:CD238
4110:CD236
4093:CD235
4088:CD234
4083:CD233
4078:CD230
4073:CD229
4068:CD228
4063:CD227
4058:CD226
4053:CD225
4048:CD224
4043:CD223
4038:CD222
4033:CD221
4028:CD220
4013:CD218
4008:CD217
3986:CD212
3964:CD209
3959:CD208
3954:CD207
3949:CD206
3944:CD205
3939:CD204
3929:CD201
3913:CD200
3898:CD197
3893:CD196
3888:CD195
3883:CD194
3878:CD193
3873:CD192
3868:CD191
3863:CD186
3858:CD185
3853:CD184
3848:CD183
3843:CD182
3838:CD181
3833:CD180
3816:CD179
3811:CD178
3806:CD177
3801:CD174
3779:CD172
3774:CD171
3769:CD170
3764:CD169
3759:CD168
3742:CD167
3737:CD166
3732:CD164
3727:CD163
3722:CD162
3717:CD161
3712:CD160
3695:CD159
3665:CD158
3660:CD157
3638:CD156
3633:CD155
3628:CD154
3623:CD153
3618:CD152
3613:CD151
3597:CD150
3592:CD148
3587:CD147
3582:CD146
3577:CD144
3572:CD143
3567:CD142
3562:CD141
3552:CD138
3547:CD137
3542:CD136
3537:CD135
3532:CD134
3527:CD133
3522:CD132
3517:CD131
3512:CD130
3507:CD129
3502:CD127
3497:CD126
3492:CD125
3487:CD124
3482:CD123
3477:CD122
3460:CD121
3443:CD120
3438:CD119
3433:CD118
3428:CD117
3423:CD116
3418:CD115
3413:CD114
3408:CD113
3403:CD112
3398:CD111
3393:CD110
3388:CD109
3383:CD108
3366:CD107
3361:CD106
3356:CD105
3351:CD104
3346:CD103
3341:CD102
3336:CD101
3320:CD100
2495:CD200
2489:CD200
2306:S2CID
2119:S2CID
1627:IL-10
1623:TGF-β
1515:DOK-2
1511:DOK-1
1384:tumor
1380:serum
1366:in a
1364:TNF-α
1360:IFN-γ
1236:CD200
886:17470
846:Mouse
841:Human
812:Amigo
402:Mouse
395:Human
342:Start
277:Mouse
241:Start
174:Human
153:CD200
112:CD200
29:CD200
4595:stub
3315:CD99
3310:CD98
3305:CD97
3300:CD96
3295:CD95
3290:CD94
3285:CD93
3280:CD92
3276:CD91
3271:CD90
3266:CD89
3261:CD88
3256:CD87
3251:CD86
3214:CD85
3209:CD84
3204:CD83
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