341:
318:
215:
240:
3381:
3366:
592:
606:
599:
3351:
347:
246:
40:
1836:-suppressed gene, upregulated during the adaptive response of prostate tumors to androgen-targeted therapies and a prognostic biomarker of clinical metastasis and lethal PCa. In vitro and in vivo mouse studies have shown membrane bound NRP1 to be proangiogenic and that NRP1 promotes the vascularization of prostate tumors.
2125:
Cantuti-Castelvetri, Ludovico; Ojha, Ravi; Pedro, Liliana D.; Djannatian, Minou; Franz, Jonas; Kuivanen, Suvi; Meer, Franziska van der; Kallio, Katri; Kaya, Tuğberk; Anastasina, Maria; Smura, Teemu; Levanov, Lev; Szirovicza, Leonora; Tobi, Allan; Kallio-Kokko, Hannimari; Österlund, Pamela; Joensuu,
2204:
Tse BW, Volpert M, Ratther E, Stylianou N, Nouri M, McGowan K, Lehman ML, McPherson SJ, Roshan-Moniri M, Butler MS, Caradec J, Gregory-Evans CY, McGovern J, Das R, Takhar M, Erho N, Alshalafa M, Davicioni E, Schaeffer EM, Jenkins RB, Ross AE, Karnes RJ, Den RB, Fazli L, Gregory PA, Gleave ME,
66:
2126:
Merja; Meunier, Frédéric A.; Butcher, Sarah J.; Winkler, Martin
Sebastian; Mollenhauer, Brit; Helenius, Ari; Gokce, Ozgun; Teesalu, Tambet; Hepojoki, Jussi; Vapalahti, Olli; Stadelmann, Christine; Balistreri, Giuseppe; Simons, Mikael (13 November 2020).
1820:
and progression of cancers. NRP1 expression has been shown to be elevated in a number of human patient tumor samples, including brain, prostate, breast, colon, and lung cancers and NRP1 levels are positively correlated with
2352:
Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, Mercurio AM (August 2001). "Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells".
1863:
in tumor cells with elevated NRP1 expression. A patent for EG3287 was filed in 2002 and approved in 2003. As of 2015 there were no clinical trials ongoing or completed for EG3287 as a human cancer therapy.
3164:
Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms".
3271:
Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA (March 2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma".
1859:, NRP1 is a potential target for cancer therapies. A synthetic peptide, EG3287, was generated in 2005 and has been shown to block NRP1 activity. EG3287 has been shown to induce
3238:"Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)"
1867:
Soluble NRP1 has the opposite effect of membrane bound NRP1 and has anti-VEGF activity. In vivo mouse studies have shown that injections of sNRP-1 inhibits progression of
3380:
3365:
2914:"Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1"
2811:
Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors".
2207:"Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality"
354:
253:
1805:
1399:
1380:
176:
2998:
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (October 1999).
3350:
3409:
3330:
1948:
2020:"Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III"
1930:
3043:"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity"
2593:"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity"
1793:
63:
2527:"A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells"
2321:
2304:
340:
1856:
1753:
1662:
1655:
2848:
Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively".
317:
2070:
1971:"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor"
1917:
1896:
3096:"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]"
239:
214:
1913:
2183:
2380:
Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, Reinmuth N, Bielenberg D, Bucana CD, Klagsbrun M, Ellis LM (June 2004).
1892:
156:
2735:"Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity"
2086:"Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain"
1789:
2432:
Hong TM, Chen YL, Wu YY, Yuan A, Chao YC, Chung YC, Wu MH, Yang SC, Pan SH, Shih JY, Chan WK, Yang PC (August 2007).
353:
252:
2256:"Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma"
1840:
3000:"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates"
3323:
2657:"Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family"
2305:"VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms"
346:
245:
2955:
Takahashi T, Fournier A, Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (October 1999).
2525:
Barr MP, Byrne AM, Duffy AM, Condron CM, Devocelle M, Harriott P, Bouchier-Hayes DJ, Harmey JH (January 2005).
1749:
1444:
164:
2879:"Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1"
2254:
Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, Hofmann M, Aharinejad S (January 2002).
1425:
2205:
Williams ED, Rennie PS, Buttyan R, Gunter JH, Selth LA, Russell PJ, Nelson CC, Hollier BG (January 2017).
1868:
228:
2877:
Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999).
3316:
3054:
2604:
2139:
143:
2778:"Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins"
2382:"Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis"
1638:
1634:
1599:
1595:
1591:
1587:
1583:
1563:
1559:
1534:
1520:
1516:
1512:
1508:
3296:
3195:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
3029:
2986:
2836:
2764:
2721:
2504:
2334:
2285:
2049:
2000:
188:
3131:"The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1"
1630:
1609:
1555:
1524:
3041:
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M (March 2000).
2591:
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M (March 2000).
3414:
3288:
3259:
3224:
3181:
3152:
3117:
3082:
3021:
2978:
2943:
2900:
2865:
2828:
2799:
2756:
2713:
2678:
2632:
2556:
2496:
2455:
2411:
2362:
2326:
2277:
2236:
2165:
2107:
2041:
1992:
136:
56:
3280:
3249:
3214:
3206:
3173:
3142:
3107:
3072:
3062:
3011:
2968:
2933:
2925:
2890:
2857:
2820:
2789:
2746:
2703:
2668:
2622:
2612:
2546:
2538:
2486:
2445:
2401:
2393:
2316:
2267:
2226:
2218:
2155:
2147:
2097:
2031:
1982:
1729:
591:
433:
364:
308:
263:
2733:
Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998).
1829:
605:
598:
408:
184:
3058:
2608:
2303:
Latil A, Bièche I, Pesche S, Valéri A, Fournier G, Cussenot O, Lidereau R (March 2000).
2143:
3219:
3194:
2938:
2929:
2913:
2551:
2526:
2406:
2381:
2231:
2206:
2160:
2127:
1777:
3016:
2999:
2973:
2956:
2794:
2777:
2751:
2734:
2708:
2691:
2673:
2656:
2574:
2397:
2036:
2019:
1987:
1970:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
39:
3403:
3077:
3042:
2627:
2592:
1773:
634:
3300:
3033:
2990:
2840:
2768:
2475:"Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression"
2289:
2084:
Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, Klagsbrun M (July 2002).
2053:
3389:: Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
3374:: Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
2725:
2508:
2338:
1817:
1769:
426:
205:
168:
3210:
2450:
2433:
2004:
3193:
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000).
192:
1953:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1935:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1852:
3047:
Proceedings of the
National Academy of Sciences of the United States of America
2597:
Proceedings of the
National Academy of Sciences of the United States of America
509:
1822:
1761:
1745:
1733:
1160:
dichotomous subdivision of terminal units involved in salivary gland branching
325:
222:
172:
2895:
2878:
2151:
1860:
1344:
1145:
neural crest cell migration involved in autonomic nervous system development
569:
447:
392:
379:
291:
278:
180:
3292:
3263:
3254:
3237:
3228:
3185:
3177:
3156:
3147:
3130:
3121:
3112:
3095:
3086:
3067:
3025:
2982:
2947:
2904:
2869:
2861:
2832:
2682:
2636:
2617:
2560:
2542:
2500:
2459:
2415:
2366:
2330:
2322:
10.1002/(SICI)1097-0215(20000320)89:2<167::AID-IJC11>3.0.CO;2-9
2281:
2240:
2169:
2111:
2102:
2085:
2803:
2760:
2717:
2491:
2474:
2045:
2018:
Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997).
1996:
1702:
1697:
1025:
semaphorin-plexin signaling pathway involved in neuron projection guidance
2222:
1833:
1686:
1489:
1470:
1290:
positive regulation of cell migration involved in sprouting angiogenesis
2957:"Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors"
2692:"Neuropilin is a receptor for the axonal chemorepellent Semaphorin III"
2272:
2255:
1718:
1456:
1411:
3284:
2184:"Neuropilin-1 drives SARS-CoV-2 infectivity, finds breakthrough study"
1065:
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
113:
109:
105:
101:
97:
93:
89:
85:
1839:
Elevated NRP1 expression is also correlated with the invasiveness of
1765:
1670:
1366:
840:
VEGF-activated neuropilin signaling pathway involved in axon guidance
17:
1969:
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998).
1808:
into cells, making it a possible target for future antiviral drugs.
1757:
1295:
positive regulation of substrate adhesion-dependent cell spreading
2824:
1329:
1325:
2434:"Targeting neuropilin 1 as an antitumor strategy in lung cancer"
2128:"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity"
1725:
1165:
cellular response to vascular endothelial growth factor stimulus
160:
3312:
1125:
positive regulation of axon extension involved in axon guidance
945:
negative regulation of axon extension involved in axon guidance
614:
3308:
3094:
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000).
678:
vascular endothelial growth factor-activated receptor activity
2473:
Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M (December 2000).
875:
vascular endothelial growth factor receptor signaling pathway
855:
semaphorin-plexin signaling pathway involved in axon guidance
920:
negative regulation of extrinsic apoptotic signaling pathway
3359:: Crystal Structure of the b1 Domain of Human Neuropilin-1
2776:
Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998).
1804:
Research has shown that neuropilin 1 facilitates entry of
860:
positive regulation of retinal ganglion cell axon guidance
975:
platelet-derived growth factor receptor signaling pathway
1300:
positive regulation of actin cytoskeleton reorganization
965:
positive regulation of peptidyl-tyrosine phosphorylation
935:
angiogenesis involved in coronary vascular morphogenesis
416:
1030:
cellular response to hepatocyte growth factor stimulus
910:
regulation of axon extension involved in axon guidance
1090:
positive regulation of endothelial cell proliferation
581:
835:
vascular endothelial growth factor signaling pathway
3236:Whitaker GB, Limberg BJ, Rosenbaum JS (July 2001).
1623:
1582:
1548:
1507:
1000:
retina vasculature morphogenesis in camera-type eye
990:
hepatocyte growth factor receptor signaling pathway
865:
positive regulation of smooth muscle cell migration
1909:
1907:
1905:
1888:
1886:
1884:
1215:substrate-dependent cell migration, cell extension
1728:. In humans, the neuropilin 1 gene is located at
1225:positive regulation of endothelial cell migration
1055:regulation of retinal ganglion cell axon guidance
850:cell migration involved in sprouting angiogenesis
363:
262:
2575:"Vegf peptides and their use (WO 2003082918 A1)"
1768:) family members. NRP1 plays versatile roles in
970:branching involved in blood vessel morphogenesis
147:, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
2199:
2197:
1235:regulation of Cdc42 protein signal transduction
1135:vestibulocochlear nerve structural organization
825:negative regulation of neuron apoptotic process
27:Protein-coding gene in the species Homo sapiens
3129:Fuh G, Garcia KC, de Vos AM (September 2000).
1914:GRCm38: Ensembl release 89: ENSMUSG00000025810
1285:positive regulation of focal adhesion assembly
3324:
1964:
1962:
8:
1280:positive regulation of stress fiber assembly
890:positive regulation of ERK1 and ERK2 cascade
1893:GRCh38: Ensembl release 89: ENSG00000099250
1250:VEGF-activated neuropilin signaling pathway
1240:substrate adhesion-dependent cell spreading
809:integral component of postsynaptic membrane
3331:
3317:
3309:
1579:
1504:
1340:
1275:positive regulation of filopodium assembly
653:vascular endothelial growth factor binding
630:
404:
303:
200:
74:
3253:
3218:
3146:
3111:
3076:
3066:
3015:
2972:
2937:
2894:
2793:
2750:
2707:
2672:
2626:
2616:
2550:
2520:
2518:
2490:
2449:
2405:
2320:
2271:
2230:
2159:
2101:
2035:
1986:
1085:ventral trunk neural crest cell migration
2065:
2063:
1816:Neuropilin 1 has been implicated in the
1120:positive regulation of cytokine activity
1110:regulation of vesicle-mediated transport
1010:axon extension involved in axon guidance
905:trigeminal nerve structural organization
3346:
2690:He Z, Tessier-Lavigne M (August 1997).
2427:
2425:
1880:
1185:sympathetic neuron projection extension
1100:endothelial tip cell fate specification
540:cardiac muscle tissue of left ventricle
1265:positive regulation of GTPase activity
1255:positive regulation of phosphorylation
1095:sympathetic nervous system development
900:protein localization to early endosome
870:sympathetic neuron projection guidance
29:
1070:negative regulation of axon extension
368:
329:
324:
267:
226:
221:
7:
2655:Zachary I, Gliki G (February 2001).
1832:NRP1 has been demonstrated to be an
1794:Vascular endothelial growth factor A
1155:axonogenesis involved in innervation
985:facial nerve structural organization
3242:The Journal of Biological Chemistry
3135:The Journal of Biological Chemistry
3100:The Journal of Biological Chemistry
2883:The Journal of Biological Chemistry
2090:The Journal of Biological Chemistry
1270:positive regulation of angiogenesis
1220:integrin-mediated signaling pathway
1190:semaphorin-plexin signaling pathway
1075:retinal ganglion cell axon guidance
2930:10.1523/JNEUROSCI.19-15-06519.1999
1754:vascular endothelial growth factor
1620:
1545:
1480:
1461:
1435:
1416:
1390:
1371:
1210:outflow tract septum morphogenesis
1140:multicellular organism development
1060:branchiomotor neuron axon guidance
1005:dorsal root ganglion morphogenesis
830:facioacoustic ganglion development
586:
504:
442:
421:
25:
2386:The American Journal of Pathology
1721:that in humans is encoded by the
1230:actin cytoskeleton reorganization
3379:
3364:
3349:
2071:"Entrez Gene: NRP1 neuropilin 1"
1015:sympathetic ganglion development
940:commissural neuron axon guidance
604:
597:
590:
352:
345:
339:
316:
251:
244:
238:
213:
38:
3273:Genes, Chromosomes & Cancer
2309:International Journal of Cancer
1788:Neuropilin 1 has been shown to
1115:trigeminal ganglion development
2912:Cai H, Reed RR (August 1999).
930:trigeminal nerve morphogenesis
744:integral component of membrane
615:More reference expression data
570:More reference expression data
1:
3017:10.1016/S0092-8674(00)80063-X
2974:10.1016/S0092-8674(00)80062-8
2795:10.1016/S0896-6273(00)80648-0
2752:10.1016/S0896-6273(00)80625-X
2709:10.1016/S0092-8674(00)80534-6
2674:10.1016/S0008-6363(00)00268-6
2451:10.1158/1078-0432.CCR-07-0001
2398:10.1016/s0002-9440(10)63772-8
2037:10.1016/S0896-6273(00)80371-2
1988:10.1016/S0092-8674(00)81402-6
915:coronary artery morphogenesis
337:
236:
3410:Genes on human chromosome 10
1245:neuropilin signaling pathway
880:sensory neuron axon guidance
663:semaphorin receptor activity
3211:10.1093/embo-reports/kvd058
2918:The Journal of Neuroscience
1847:Target for cancer therapies
1843:both in vitro and in vivo.
1732:. This is one of two human
1315:basal dendrite arborization
1150:endothelial cell chemotaxis
729:semaphorin receptor complex
490:subcutaneous adipose tissue
458:stromal cell of endometrium
3431:
1841:non-small cell lung cancer
1310:basal dendrite development
1260:endothelial cell migration
1170:motor neuron axon guidance
1080:renal artery morphogenesis
1050:nervous system development
895:animal organ morphogenesis
548:superior cervical ganglion
3344:
2531:British Journal of Cancer
1949:"Mouse PubMed Reference:"
1931:"Human PubMed Reference:"
1744:NRP1 is a membrane-bound
1701:
1696:
1692:
1685:
1669:
1663:Chr 8: 129.09 – 129.23 Mb
1650:
1627:
1606:
1575:
1552:
1531:
1500:
1487:
1483:
1468:
1464:
1455:
1442:
1438:
1423:
1419:
1410:
1397:
1393:
1378:
1374:
1365:
1350:
1343:
1339:
1323:
693:GTPase activator activity
633:
629:
612:
589:
580:
567:
516:
507:
454:
445:
415:
407:
403:
386:
373:
336:
315:
306:
302:
285:
272:
235:
212:
203:
199:
154:
151:
141:
134:
129:
82:
77:
60:
55:
50:
46:
37:
32:
2896:10.1074/jbc.274.30.21217
2438:Clinical Cancer Research
1750:tyrosine kinase receptor
1656:Chr 10: 33.18 – 33.34 Mb
1305:postsynapse organization
1200:otic placode development
2661:Cardiovascular Research
2152:10.1126/science.abd2985
524:external carotid artery
520:internal carotid artery
3255:10.1074/jbc.M102315200
3178:10.1006/geno.2000.6381
3148:10.1074/jbc.M003955200
3113:10.1074/jbc.M909259199
3068:10.1073/pnas.040337597
2862:10.1006/geno.1999.5790
2618:10.1073/pnas.040337597
2543:10.1038/sj.bjc.6602308
2103:10.1074/jbc.M200730200
1869:acute myeloid leukemia
1205:motor neuron migration
1040:sprouting angiogenesis
698:protein kinase binding
2492:10.1096/fj.00-0250com
1812:Implication in cancer
804:glutamatergic synapse
683:growth factor binding
528:stroma of bone marrow
229:Chromosome 10 (human)
2223:10.1038/onc.2016.482
1035:dendrite development
1020:cell differentiation
995:axonal fasciculation
960:artery morphogenesis
955:response to wounding
724:extracellular region
494:smooth muscle tissue
370:8 E2|8 75.78 cM
331:Chromosome 8 (mouse)
78:List of PDB id codes
51:Available structures
3059:2000PNAS...97.2573G
2813:Nature Neuroscience
2609:2000PNAS...97.2573G
2144:2020Sci...370..856C
1195:signal transduction
1105:cell-cell signaling
980:positive chemotaxis
789:extracellular space
784:cytoplasmic vesicle
668:coreceptor activity
544:trigeminal ganglion
478:epithelium of colon
2273:10.1002/cncr.10177
1445:ENSMUSG00000025810
925:neuron development
818:Biological process
769:neuronal cell body
707:Cellular component
641:Molecular function
3397:
3396:
3285:10.1002/gcc.10028
2217:(24): 3417–3427.
2138:(6518): 856–860.
1776:, cell survival,
1712:
1711:
1708:
1707:
1681:
1680:
1646:
1645:
1617:
1616:
1571:
1570:
1542:
1541:
1496:
1495:
1477:
1476:
1451:
1450:
1432:
1431:
1406:
1405:
1387:
1386:
1335:
1334:
1175:nerve development
950:heart development
799:neuron projection
673:metal ion binding
625:
624:
621:
620:
576:
575:
563:
562:
501:
500:
399:
398:
298:
297:
125:
124:
121:
120:
61:Ortholog search:
16:(Redirected from
3422:
3383:
3368:
3353:
3333:
3326:
3319:
3310:
3304:
3267:
3257:
3248:(27): 25520–31.
3232:
3222:
3189:
3160:
3150:
3125:
3115:
3090:
3080:
3070:
3037:
3019:
2994:
2976:
2951:
2941:
2908:
2898:
2889:(30): 21217–22.
2873:
2844:
2807:
2797:
2772:
2754:
2729:
2711:
2686:
2676:
2641:
2640:
2630:
2620:
2588:
2582:
2581:
2579:
2571:
2565:
2564:
2554:
2522:
2513:
2512:
2494:
2470:
2464:
2463:
2453:
2429:
2420:
2419:
2409:
2377:
2371:
2370:
2349:
2343:
2342:
2324:
2300:
2294:
2293:
2275:
2251:
2245:
2244:
2234:
2201:
2192:
2191:
2180:
2174:
2173:
2163:
2122:
2116:
2115:
2105:
2096:(27): 24818–25.
2081:
2075:
2074:
2067:
2058:
2057:
2039:
2015:
2009:
2008:
1990:
1966:
1957:
1956:
1945:
1939:
1938:
1927:
1921:
1911:
1900:
1890:
1800:Role in COVID-19
1780:, and invasion.
1694:
1693:
1665:
1658:
1641:
1621:
1612:
1580:
1576:RefSeq (protein)
1566:
1546:
1537:
1505:
1481:
1462:
1436:
1417:
1391:
1372:
1341:
1045:neuron migration
754:receptor complex
739:sorting endosome
658:cytokine binding
631:
617:
608:
601:
594:
587:
572:
512:
510:Top expressed in
505:
450:
448:Top expressed in
443:
422:
405:
395:
382:
371:
356:
349:
343:
332:
320:
304:
294:
281:
270:
255:
248:
242:
231:
217:
201:
195:
193:NRP1 - orthologs
146:
139:
116:
75:
69:
48:
47:
42:
30:
21:
3430:
3429:
3425:
3424:
3423:
3421:
3420:
3419:
3400:
3399:
3398:
3393:
3390:
3384:
3375:
3369:
3360:
3354:
3340:
3337:
3307:
3270:
3235:
3192:
3163:
3141:(35): 26690–5.
3128:
3106:(24): 18040–5.
3093:
3040:
2997:
2954:
2924:(15): 6519–27.
2911:
2876:
2847:
2810:
2775:
2732:
2689:
2654:
2650:
2648:Further reading
2645:
2644:
2590:
2589:
2585:
2577:
2573:
2572:
2568:
2524:
2523:
2516:
2472:
2471:
2467:
2444:(16): 4759–68.
2431:
2430:
2423:
2379:
2378:
2374:
2361:(15): 5736–40.
2355:Cancer Research
2351:
2350:
2346:
2302:
2301:
2297:
2253:
2252:
2248:
2203:
2202:
2195:
2182:
2181:
2177:
2124:
2123:
2119:
2083:
2082:
2078:
2069:
2068:
2061:
2017:
2016:
2012:
1968:
1967:
1960:
1947:
1946:
1942:
1929:
1928:
1924:
1912:
1903:
1891:
1882:
1877:
1849:
1830:prostate cancer
1818:vascularization
1814:
1802:
1786:
1742:
1703:View/Edit Mouse
1698:View/Edit Human
1661:
1654:
1651:Location (UCSC)
1637:
1633:
1629:
1608:
1602:
1598:
1594:
1590:
1586:
1562:
1558:
1554:
1533:
1527:
1523:
1519:
1515:
1511:
1426:ENSG00000099250
1319:
845:toxin transport
813:
759:plasma membrane
702:
688:protein binding
648:heparin binding
613:
603:
602:
596:
595:
568:
559:
554:
550:
546:
542:
538:
536:renal corpuscle
534:
530:
526:
522:
508:
497:
492:
488:
484:
480:
476:
474:right ventricle
472:
468:
466:Achilles tendon
464:
460:
446:
390:
377:
369:
359:
358:
357:
350:
330:
307:Gene location (
289:
276:
268:
258:
257:
256:
249:
227:
204:Gene location (
155:
142:
135:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3428:
3426:
3418:
3417:
3412:
3402:
3401:
3395:
3394:
3392:
3391:
3385:
3378:
3376:
3370:
3363:
3361:
3355:
3348:
3345:
3342:
3341:
3338:
3336:
3335:
3328:
3321:
3313:
3306:
3305:
3279:(3): 295–303.
3268:
3233:
3190:
3161:
3126:
3091:
3038:
2995:
2952:
2909:
2874:
2845:
2808:
2788:(6): 1283–90.
2773:
2745:(5): 1079–92.
2730:
2687:
2651:
2649:
2646:
2643:
2642:
2583:
2580:. Oct 9, 2003.
2566:
2514:
2485:(15): 2532–9.
2465:
2421:
2392:(6): 2139–51.
2372:
2344:
2295:
2246:
2193:
2175:
2117:
2076:
2059:
2010:
1958:
1940:
1922:
1901:
1879:
1878:
1876:
1873:
1848:
1845:
1813:
1810:
1801:
1798:
1785:
1782:
1764:(for example,
1756:(for example,
1741:
1738:
1710:
1709:
1706:
1705:
1700:
1690:
1689:
1683:
1682:
1679:
1678:
1676:
1674:
1667:
1666:
1659:
1652:
1648:
1647:
1644:
1643:
1625:
1624:
1618:
1615:
1614:
1604:
1603:
1577:
1573:
1572:
1569:
1568:
1550:
1549:
1543:
1540:
1539:
1529:
1528:
1502:
1498:
1497:
1494:
1493:
1485:
1484:
1478:
1475:
1474:
1466:
1465:
1459:
1453:
1452:
1449:
1448:
1440:
1439:
1433:
1430:
1429:
1421:
1420:
1414:
1408:
1407:
1404:
1403:
1395:
1394:
1388:
1385:
1384:
1376:
1375:
1369:
1363:
1362:
1357:
1352:
1348:
1347:
1337:
1336:
1333:
1332:
1321:
1320:
1318:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1180:cell migration
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
821:
819:
815:
814:
812:
811:
806:
801:
796:
794:focal adhesion
791:
786:
781:
776:
774:early endosome
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
710:
708:
704:
703:
701:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
644:
642:
638:
637:
627:
626:
623:
622:
619:
618:
610:
609:
584:
578:
577:
574:
573:
565:
564:
561:
560:
558:
557:
553:
552:left lung lobe
549:
545:
541:
537:
533:
529:
525:
521:
517:
514:
513:
502:
499:
498:
496:
495:
491:
487:
486:left ventricle
483:
479:
475:
471:
470:synovial joint
467:
463:
459:
455:
452:
451:
439:
438:
430:
419:
413:
412:
409:RNA expression
401:
400:
397:
396:
388:
384:
383:
375:
372:
367:
361:
360:
351:
344:
338:
334:
333:
328:
322:
321:
313:
312:
300:
299:
296:
295:
287:
283:
282:
274:
271:
266:
260:
259:
250:
243:
237:
233:
232:
225:
219:
218:
210:
209:
197:
196:
153:
149:
148:
140:
132:
131:
127:
126:
123:
122:
119:
118:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3427:
3416:
3413:
3411:
3408:
3407:
3405:
3388:
3382:
3377:
3373:
3367:
3362:
3358:
3352:
3347:
3343:
3334:
3329:
3327:
3322:
3320:
3315:
3314:
3311:
3302:
3298:
3294:
3290:
3286:
3282:
3278:
3274:
3269:
3265:
3261:
3256:
3251:
3247:
3243:
3239:
3234:
3230:
3226:
3221:
3216:
3212:
3208:
3205:(3): 287–92.
3204:
3200:
3196:
3191:
3187:
3183:
3179:
3175:
3172:(2): 211–22.
3171:
3167:
3162:
3158:
3154:
3149:
3144:
3140:
3136:
3132:
3127:
3123:
3119:
3114:
3109:
3105:
3101:
3097:
3092:
3088:
3084:
3079:
3074:
3069:
3064:
3060:
3056:
3053:(6): 2573–8.
3052:
3048:
3044:
3039:
3035:
3031:
3027:
3023:
3018:
3013:
3009:
3005:
3001:
2996:
2992:
2988:
2984:
2980:
2975:
2970:
2966:
2962:
2958:
2953:
2949:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2910:
2906:
2902:
2897:
2892:
2888:
2884:
2880:
2875:
2871:
2867:
2863:
2859:
2856:(3): 459–60.
2855:
2851:
2846:
2842:
2838:
2834:
2830:
2826:
2822:
2819:(6): 487–93.
2818:
2814:
2809:
2805:
2801:
2796:
2791:
2787:
2783:
2779:
2774:
2770:
2766:
2762:
2758:
2753:
2748:
2744:
2740:
2736:
2731:
2727:
2723:
2719:
2715:
2710:
2705:
2702:(4): 739–51.
2701:
2697:
2693:
2688:
2684:
2680:
2675:
2670:
2667:(3): 568–81.
2666:
2662:
2658:
2653:
2652:
2647:
2638:
2634:
2629:
2624:
2619:
2614:
2610:
2606:
2603:(6): 2573–8.
2602:
2598:
2594:
2587:
2584:
2576:
2570:
2567:
2562:
2558:
2553:
2548:
2544:
2540:
2537:(2): 328–33.
2536:
2532:
2528:
2521:
2519:
2515:
2510:
2506:
2502:
2498:
2493:
2488:
2484:
2480:
2479:FASEB Journal
2476:
2469:
2466:
2461:
2457:
2452:
2447:
2443:
2439:
2435:
2428:
2426:
2422:
2417:
2413:
2408:
2403:
2399:
2395:
2391:
2387:
2383:
2376:
2373:
2368:
2364:
2360:
2356:
2348:
2345:
2340:
2336:
2332:
2328:
2323:
2318:
2315:(2): 167–71.
2314:
2310:
2306:
2299:
2296:
2291:
2287:
2283:
2279:
2274:
2269:
2266:(1): 258–63.
2265:
2261:
2257:
2250:
2247:
2242:
2238:
2233:
2228:
2224:
2220:
2216:
2212:
2208:
2200:
2198:
2194:
2189:
2188:MedicalXpress
2185:
2179:
2176:
2171:
2167:
2162:
2157:
2153:
2149:
2145:
2141:
2137:
2133:
2129:
2121:
2118:
2113:
2109:
2104:
2099:
2095:
2091:
2087:
2080:
2077:
2072:
2066:
2064:
2060:
2055:
2051:
2047:
2043:
2038:
2033:
2030:(3): 547–59.
2029:
2025:
2021:
2014:
2011:
2006:
2002:
1998:
1994:
1989:
1984:
1981:(6): 735–45.
1980:
1976:
1972:
1965:
1963:
1959:
1954:
1950:
1944:
1941:
1936:
1932:
1926:
1923:
1919:
1915:
1910:
1908:
1906:
1902:
1898:
1894:
1889:
1887:
1885:
1881:
1874:
1872:
1870:
1865:
1862:
1858:
1854:
1846:
1844:
1842:
1837:
1835:
1831:
1826:
1824:
1819:
1811:
1809:
1807:
1799:
1797:
1795:
1791:
1783:
1781:
1779:
1775:
1774:axon guidance
1771:
1767:
1763:
1759:
1755:
1751:
1747:
1739:
1737:
1735:
1731:
1727:
1724:
1720:
1716:
1704:
1699:
1695:
1691:
1688:
1684:
1677:
1675:
1672:
1668:
1664:
1660:
1657:
1653:
1649:
1642:
1640:
1636:
1632:
1626:
1622:
1619:
1613:
1611:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1578:
1574:
1567:
1565:
1561:
1557:
1551:
1547:
1544:
1538:
1536:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1503:
1501:RefSeq (mRNA)
1499:
1492:
1491:
1486:
1482:
1479:
1473:
1472:
1467:
1463:
1460:
1458:
1454:
1447:
1446:
1441:
1437:
1434:
1428:
1427:
1422:
1418:
1415:
1413:
1409:
1402:
1401:
1396:
1392:
1389:
1383:
1382:
1377:
1373:
1370:
1368:
1364:
1361:
1358:
1356:
1353:
1349:
1346:
1342:
1338:
1331:
1327:
1322:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1130:axon guidance
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
822:
820:
817:
816:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
779:neurofilament
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
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750:
747:
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742:
740:
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727:
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715:
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666:
664:
661:
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651:
649:
646:
645:
643:
640:
639:
636:
635:Gene ontology
632:
628:
616:
611:
607:
600:
593:
588:
585:
583:
579:
571:
566:
555:
551:
547:
543:
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531:
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394:
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366:
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355:
348:
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327:
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305:
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280:
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265:
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254:
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138:
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128:
117:
115:
111:
107:
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99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3386:
3371:
3356:
3276:
3272:
3245:
3241:
3202:
3199:EMBO Reports
3198:
3169:
3165:
3138:
3134:
3103:
3099:
3050:
3046:
3010:(1): 71–80.
3007:
3003:
2967:(1): 59–69.
2964:
2960:
2921:
2917:
2886:
2882:
2853:
2849:
2825:10.1038/2203
2816:
2812:
2785:
2781:
2742:
2738:
2699:
2695:
2664:
2660:
2600:
2596:
2586:
2569:
2534:
2530:
2482:
2478:
2468:
2441:
2437:
2389:
2385:
2375:
2358:
2354:
2347:
2312:
2308:
2298:
2263:
2259:
2249:
2214:
2210:
2187:
2178:
2135:
2131:
2120:
2093:
2089:
2079:
2027:
2023:
2013:
1978:
1974:
1952:
1943:
1934:
1925:
1866:
1850:
1838:
1827:
1815:
1803:
1787:
1784:Interactions
1770:angiogenesis
1743:
1722:
1715:Neuropilin-1
1714:
1713:
1639:NP_001345889
1635:NP_001345888
1628:
1607:
1600:NP_001316997
1596:NP_001231902
1592:NP_001231901
1588:NP_001019800
1584:NP_001019799
1564:NM_001358960
1560:NM_001358959
1553:
1535:NM_001330068
1532:
1521:NM_001244973
1517:NM_001244972
1513:NM_001024629
1509:NM_001024628
1488:
1469:
1443:
1424:
1398:
1379:
1359:
1354:
885:angiogenesis
734:cell surface
556:carotid body
432:
425:
391:129,229,844
378:129,085,085
152:External IDs
83:
3339:PDB gallery
1853:co-receptor
1734:neuropilins
749:growth cone
482:gallbladder
462:pericardium
290:33,336,262
277:33,177,492
130:Identifiers
3404:Categories
1920:, May 2017
1899:, May 2017
1875:References
1823:metastasis
1806:SARS-CoV-2
1762:semaphorin
1746:coreceptor
436:(ortholog)
173:HomoloGene
1871:in mice.
1861:apoptosis
1778:migration
1752:for both
1631:NP_032763
1610:NP_003864
1556:NM_008737
1525:NM_003873
1345:Orthologs
532:left lung
181:GeneCards
3415:Proteins
3301:33428561
3293:11807987
3264:11333271
3229:11256614
3186:11112349
3166:Genomics
3157:10842181
3122:10748121
3087:10688880
3034:17386412
3026:10520995
2991:18167425
2983:10520994
2948:10414980
2905:10409677
2870:10329017
2850:Genomics
2841:38320889
2833:10196546
2769:18445456
2683:11166270
2637:10688880
2578:(patent)
2561:15655556
2501:11099472
2460:17699853
2416:15161648
2367:11479209
2331:10754495
2290:45773136
2282:11815985
2241:28092670
2211:Oncogene
2170:33082293
2112:11986311
2054:17985062
1916:–
1895:–
1834:androgen
1790:interact
1740:Function
1730:10p11.22
1687:Wikidata
1324:Sources:
719:membrane
269:10p11.22
3220:1083732
3055:Bibcode
2939:6782790
2804:9883722
2761:9856463
2726:9720408
2718:9288753
2605:Bibcode
2552:2361857
2509:2370002
2407:1615754
2339:7393385
2232:5485179
2161:7857391
2140:Bibcode
2132:Science
2046:9331348
1997:9529250
1918:Ensembl
1897:Ensembl
1719:protein
1457:UniProt
1412:Ensembl
1351:Species
1330:QuickGO
714:cytosol
411:pattern
137:Aliases
3299:
3291:
3262:
3227:
3217:
3184:
3155:
3120:
3085:
3075:
3032:
3024:
2989:
2981:
2946:
2936:
2903:
2868:
2839:
2831:
2802:
2782:Neuron
2767:
2759:
2739:Neuron
2724:
2716:
2681:
2635:
2625:
2559:
2549:
2507:
2499:
2458:
2414:
2404:
2365:
2337:
2329:
2288:
2280:
2260:Cancer
2239:
2229:
2168:
2158:
2110:
2052:
2044:
2024:Neuron
2005:547080
2003:
1995:
1766:SEMA3A
1760:) and
1673:search
1671:PubMed
1490:P97333
1471:O14786
1367:Entrez
582:BioGPS
169:106206
161:602069
3297:S2CID
3078:15970
3030:S2CID
2987:S2CID
2837:S2CID
2765:S2CID
2722:S2CID
2628:15970
2505:S2CID
2335:S2CID
2286:S2CID
2050:S2CID
2001:S2CID
1851:As a
1792:with
1758:VEGFA
1748:to a
1717:is a
1400:18186
1360:Mouse
1355:Human
1326:Amigo
434:Mouse
427:Human
374:Start
309:Mouse
273:Start
206:Human
18:CD304
3387:2orz
3372:2orx
3357:1kex
3289:PMID
3260:PMID
3225:PMID
3182:PMID
3153:PMID
3118:PMID
3083:PMID
3022:PMID
3004:Cell
2979:PMID
2961:Cell
2944:PMID
2901:PMID
2866:PMID
2829:PMID
2800:PMID
2757:PMID
2714:PMID
2696:Cell
2679:PMID
2633:PMID
2557:PMID
2497:PMID
2456:PMID
2412:PMID
2363:PMID
2327:PMID
2278:PMID
2237:PMID
2166:PMID
2108:PMID
2042:PMID
1993:PMID
1975:Cell
1857:VEGF
1855:for
1726:gene
1723:NRP1
1381:8829
764:axon
417:Bgee
365:Band
326:Chr.
264:Band
223:Chr.
185:NRP1
177:2876
157:OMIM
144:NRP1
114:5C7G
110:4RN5
106:4DEQ
102:3I97
98:2QQN
94:2QQM
90:2QQI
86:1KEX
67:RCSB
64:PDBe
33:NRP1
3281:doi
3250:doi
3246:276
3215:PMC
3207:doi
3174:doi
3143:doi
3139:275
3108:doi
3104:275
3073:PMC
3063:doi
3012:doi
2969:doi
2934:PMC
2926:doi
2891:doi
2887:274
2858:doi
2821:doi
2790:doi
2747:doi
2704:doi
2669:doi
2623:PMC
2613:doi
2547:PMC
2539:doi
2487:doi
2446:doi
2402:PMC
2394:doi
2390:164
2317:doi
2268:doi
2227:PMC
2219:doi
2156:PMC
2148:doi
2136:370
2098:doi
2094:277
2032:doi
1983:doi
1828:In
387:End
286:End
189:OMA
165:MGI
57:PDB
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