1390:
312:
289:
1345:(siRNA) led to a reduction of proliferation, migration, and invasion of breast cancer cells in vitro supporting the role of EpCAM in promoting EMT. In another study, cells undergoing EMT were found to downregulate EpCAM. In one study, epithelial tumors were often strongly positive for EpCAM, but mesenchymal tumors showed only occasional and weak positivity. It has been suggested that EpCAM expression is downregulated during EMT but then upregulated once the metastasis reaches its future tumor site.
186:
211:
563:
318:
217:
1363:. However, the heterogeneous expression of EpCAM in carcinomas and the fact that EpCAM is not tumor-specific (i.e., it is found in normal epithelium) raise concerns that immunotherapy directed towards EpCAM could have severe side effects. As the role of EpCAM in cancer cell signaling is better understood, EpCAM signaling rather than EpCAM itself may be a target for therapeutic intervention.
1341:(EMT) in tumors, although its exact effects are poorly understood. Its ability to suppress E-cadherin suggests that EpCAM would promote EMT and tumor metastasis, but its homotypic cell adhesion properties can counteract its ability to suppress E-cadherin. Results from different studies are often conflicting. In one study, for example, silencing of EpCAM with
1195:
EpCAM is frequently upregulated in carcinomas but is not expressed in cancers of non-epithelial origin. In cancer cells, EpCAM is expressed in a dispersed pattern across the cell membrane. However, EpCAM expression in carcinomas is often heterogeneous; some cells in a tumor have more EpCAM than other
1317:
potential. Upon cleavage, the extracellular domain (EpEX) is released into the area surrounding the cell, and the intracellular domain (EpICD) is released into the cytoplasm of the cell. EpICD forms a complex with the proteins FHL2, Ξ²-catenin, and Lef inside the nucleus. This complex then binds to
1275:
EpCAM was first found to play a role in homotypic cell adhesion. This means that EpCAM on the surface of one cell binds to the EpCAM on a neighboring cell thereby holding the cells together. The adhesions mediated by EpCAM are relatively weak, as compared to some other adhesion molecules, such as
1160:
on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different times. EpCAM therefore has many aliases the most notable of which include TACSTD1 (tumor-associated calcium signal transducer 1), CD326 (cluster of differentiation 326), and the 17-1A
1293:
The homotypic adhesive activity has been questioned, as a variety of in vivo and in vitro biochemical experiments have failed to detect trans-interactions. EpCAM pro-adhesive activity could be explained by alternative models, based on its ability to regulate PKC signalling and myosin activity.
1358:
It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less accessible to antibodies than EpCAM in cancer tissue, where it is homogeneously distributed on the cancer cell surface. In addition to being overexpressed in many
1304:
EpCAM expression. This is especially evident in tissues that normally reveal no or low levels of EpCAM expression, such as squamous epithelium. The level of EpCAM expression correlates with the proliferative activity of intestinal cells, and inversely correlates with their differentiation.
65:
1258:
repeat-like domains, a single transmembrane domain (23 amino acids), and a short intracellular domain (26 amino acids). The extracellular domain is sometimes referred to as EpEX, and the intracellular domain is sometimes referred to as EpICD.
2517:
Punt CJ, Nagy A, Douillard JY, Figer A, Skovsgaard T, Monson J, et al. (August 2002). "Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study".
1282:
EpCAM has a negative impact on cadherin-mediated adhesions. Overexpression of EpCAM does not alter overall total cellular level of cadherins but rather decreases the association of the cadherin/
3671:
2810:
1330:
A & E. This has the effect of promoting tumor growth. Additionally, EpEX that has been cleaved can stimulate the cleavage of additional EpCAM molecules resulting in a
1246:, 30- to 40-kDa type I membrane protein. The sequence of the EpCAM molecule predicts the presence of three potential N-linked glycosylation sites. It is composed of 314
325:
224:
1827:
Herlyn D, Herlyn M, Steplewski Z, Koprowski H (August 1979). "Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma".
3661:
1693:"Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation"
1279:
EpICD is required for EpCAM to mediate intercellular adhesion; EpCAM mediates intercellular adhesion and associates with the actin cytoskeleton via EpICD.
3641:
2778:
831:
2747:
812:
147:
4503:
2827:
2803:
2392:
Patriarca C, Macchi RM, Marschner AK, Mellstedt H (February 2012). "Epithelial cell adhesion molecule expression (CD326) in cancer: a short review".
118:, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, BerEp4, MOC-31, Ber-Ep4
4234:
1164:
EpCAM expression is not limited to human colon carcinomas; in fact, EpCAM is expressed in a variety of human epithelial tissues, carcinomas, and
2020:
Went PT, Lugli A, Meier S, Bundi M, Mirlacher M, Sauter G, Dirnhofer S (January 2004). "Frequent EpCam protein expression in human carcinomas".
1199:
Squamous carcinomas often express EpCAM whereas normal squamous cells do not express EpCAM. EpCAM expression differs between different types of
4222:
4000:
4286:
4281:
4227:
4007:
2788:
1528:
1601:
Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, et al. (February 2009). "Nuclear signalling by tumour-associated antigen EpCAM".
1510:
4840:
4835:
3740:
3666:
2796:
1389:
1180:
stratified epithelia are negative for EpCAM. The level of expression may differ significantly between the individual tissue types. In the
311:
62:
4769:
4764:
4759:
4754:
3681:
1038:
1031:
288:
1338:
3970:
4538:
4032:
3718:
1497:
1476:
1219:
Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of
4177:
3713:
1449:
1290:. As EpCAM expression increases, the total amount of Ξ±-catenin decreases, whereas cellular Ξ²-catenin levels remain constant.
1493:
210:
185:
4674:
4146:
4141:
4086:
3820:
3269:
1437:, a genetic disorder that leads to increased risk of cancer. Deletion of a portion of the 3' end of the EpCAM gene causes
1472:
4368:
4091:
2755:
127:
3686:
1172:. However, EpCAM is not found in non-epithelial cells or cancers of non-epithelial origin. EpCAM is expressed on the
324:
223:
4398:
2823:
1393:
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having
1116:. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has
1148:, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.
1109:
317:
216:
3264:
4448:
3343:
2769:
876:
135:
2617:"Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma"
4412:
1251:
1220:
857:
2106:"Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins"
1267:
The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles.
1184:, the gastric epithelium expresses very low levels of EpCAM. Expression levels are substantially higher in
3755:
3750:
3745:
3735:
3042:
2970:
2760:
2744:
1926:
Balzar M, Winter MJ, de Boer CJ, Litvinov SV (October 1999). "The biology of the 17-1A antigen (Ep-CAM)".
1181:
2212:"EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review"
2104:
Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F, et al. (December 1997).
2057:"Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule"
1176:
of all simple (especially glandular), pseudo-stratified, and transitional epithelia. In contrast, normal
3099:
3017:
2353:"Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma"
1378:
1342:
1691:
Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van
Krieken H, Fleuren GJ, Warnaar SO (March 1996).
4336:
4049:
2166:
1418:
1414:
1394:
1173:
199:
114:
2765:
4363:
4182:
1649:"EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy"
3770:
3504:
2543:
2241:
1951:
1852:
1763:
1626:
159:
2429:"Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells"
1014:
993:
967:
946:
562:
2427:
Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, et al. (April 2009).
1297:
Recently, it has been discovered that EpCAM contributes to the maintenance of tight junctions.
2724:
2675:
2648:
2594:
2535:
2499:
2458:
2409:
2374:
2333:
2282:
2233:
2192:
2135:
2086:
2055:
Balzar M, Bakker HA, Briaire-de-Bruijn IH, Fleuren GJ, Warnaar SO, Litvinov SV (August 1998).
2037:
1999:
1943:
1901:
1844:
1809:
1755:
1714:
1670:
1618:
1580:
1331:
107:
55:
2476:
van der Gun BT, Melchers LJ, Ruiters MH, de Leij LF, McLaughlin PM, Rots MG (November 2010).
4543:
4276:
4197:
3760:
2953:
2879:
2714:
2706:
2638:
2628:
2584:
2574:
2527:
2489:
2448:
2440:
2401:
2364:
2323:
2313:
2272:
2223:
2182:
2174:
2125:
2117:
2076:
2068:
2029:
1989:
1935:
1891:
1883:
1836:
1799:
1745:
1704:
1660:
1610:
1570:
1562:
1323:
1211:. All of this points towards the utility of EpCAM as a diagnostic tool for various cancers.
1125:
404:
335:
279:
234:
1359:
carcinomas, EpCAM is expressed in cancer stem cells, making EpCAM an attractive target for
1136:, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in
155:
4603:
3139:
3134:
3057:
2751:
1397:(BCC) with squamous cell metaplasia. Only BCC cells are stained with BerEP4 in this image.
1208:
1189:
1185:
379:
2693:
Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, et al. (August 2008).
1734:"The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation"
1334:
loop. The amount of Ξ²-catenin in the nucleus can modulate the expression level of EpCAM.
2170:
1647:
Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, et al. (August 2004).
4388:
3810:
3321:
3124:
2719:
2694:
2643:
2616:
2589:
2563:"The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma"
2562:
2453:
2428:
2328:
2301:
2261:"EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC"
2187:
2154:
2130:
2105:
1896:
1871:
1709:
1692:
1575:
1550:
1434:
1300:
Active proliferation in a number of epithelial tissues is associated with increased or
1236:
2531:
2153:
Gaber A, Kim SJ, Kaake RM, BenΔina M, Krogan N, Ε ali A, et al. (September 2018).
2081:
2056:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
680:
675:
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665:
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640:
635:
630:
614:
609:
604:
4829:
4358:
3815:
2906:
2782:
2245:
1406:
1360:
1318:
DNA and promotes the transcription of various genes. Targets of upregulation include
1255:
1137:
1102:
591:
2547:
2302:"Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier"
1955:
1856:
1767:
1132:
A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived
4714:
4022:
4012:
3543:
3509:
1630:
1410:
1287:
1243:
1192:
EpCAM is probably expressed at the highest levels among all epithelial cell types.
1105:
397:
176:
139:
2444:
2369:
2352:
2033:
1994:
1977:
1665:
1648:
2710:
2277:
2260:
163:
4724:
4373:
4151:
4126:
3825:
3447:
3373:
2847:
2228:
2211:
2155:"EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion"
1551:"Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule"
1533:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1515:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1374:
1370:
1366:
1247:
2405:
2178:
480:
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4059:
3800:
3676:
3309:
3304:
3299:
3154:
2938:
1438:
1169:
1165:
1156:
First discovered in 1979, EpCAM was initially described as a dominant surface
1145:
1141:
296:
193:
143:
4493:
4488:
4483:
4473:
4468:
4463:
4458:
2494:
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1402:
1314:
1232:
1228:
1224:
1133:
1117:
1113:
776:
540:
418:
363:
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262:
249:
151:
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2503:
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2237:
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2121:
2041:
2003:
1947:
1905:
1887:
1840:
1813:
1759:
1750:
1733:
1674:
1622:
1417:
of the skin. The diagnosis of such conditions can therefore be assisted by
2318:
2139:
2090:
2072:
1939:
1718:
1584:
1566:
1078:
1073:
4799:
4699:
4513:
4498:
3701:
3696:
3604:
3294:
1848:
1549:
Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (April 1994).
1204:
1177:
1062:
921:
902:
2695:"Identification of EpCAM as the gene for congenital tufting enteropathy"
1804:
1787:
4749:
4744:
4739:
4639:
4453:
4443:
4270:
4249:
4244:
4212:
4017:
3937:
3932:
3927:
3922:
3917:
3835:
3528:
3368:
3363:
3358:
3353:
3348:
2819:
2633:
1327:
1283:
1157:
1129:
888:
843:
2259:
Maghzal N, Kayali HA, Rohani N, Kajava AV, Fagotto F (November 2013).
1203:
cell carcinomas, and EpCAM expression increases during development of
84:
4689:
4649:
4634:
4618:
4613:
4593:
4588:
4523:
4331:
4301:
4265:
4256:
4069:
4037:
3901:
3896:
3866:
3845:
3805:
3765:
3631:
3609:
3568:
3492:
3487:
3482:
3477:
3472:
3467:
3336:
3331:
3326:
3274:
3259:
3129:
3119:
3082:
3077:
2995:
2990:
1422:
1046:
798:
17:
1614:
1732:
MΓΌnz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (July 2004).
1250:. EpCAM consists of an extracellular domain (242 amino acids) with
4814:
4789:
4709:
4704:
4694:
4684:
4669:
4664:
4659:
4644:
4598:
4583:
4548:
4533:
4528:
4518:
4438:
4433:
4428:
4407:
4403:
4393:
4306:
4207:
4202:
4161:
4111:
4106:
4101:
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4081:
4074:
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3619:
3599:
3594:
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3584:
3538:
3430:
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3244:
3228:
3221:
3216:
3211:
3206:
3201:
3196:
3171:
3149:
3144:
3037:
2963:
2958:
2948:
1319:
1200:
1121:
761:
757:
4809:
4804:
4794:
4784:
4779:
4774:
4729:
4719:
4679:
4608:
4578:
4573:
4568:
4563:
4558:
4553:
4508:
4478:
4383:
4351:
4346:
4326:
4316:
4311:
4296:
4291:
4192:
4187:
4156:
4136:
4131:
4121:
4116:
3995:
3948:
3908:
3563:
3558:
3553:
3548:
3533:
3524:
3519:
3514:
3499:
3457:
3452:
3442:
3437:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3316:
3289:
3284:
3279:
3254:
3249:
3186:
3181:
3176:
3166:
3161:
3114:
3109:
3104:
3094:
3089:
3072:
3067:
3062:
3052:
3047:
3032:
3027:
3022:
3012:
3007:
3002:
2985:
2980:
2975:
2926:
2894:
2889:
2884:
2867:
2862:
2857:
2852:
1442:
131:
2792:
2666:
Tomita N, Yamano T, Matsubara N, Tamura K (February 2013). "".
1445:
gene by hypermethylating the promoter region of the MSH2 gene.
571:
4321:
2933:
2921:
2916:
2911:
2901:
2874:
2842:
1978:"The emerging role of EpCAM in cancer and stem cell signaling"
707:
negative regulation of cell-cell adhesion mediated by cadherin
712:
signal transduction involved in regulation of gene expression
1788:"EpCAM: A new therapeutic target for an old cancer antigen"
2351:
Yamashita T, Budhu A, Forgues M, Wang XW (November 2007).
2300:
Varadarajan S, Raya-Sandino A, Nusrat A (December 2022).
747:
cell-cell adhesion via plasma-membrane adhesion molecules
737:
positive regulation of transcription by RNA polymerase II
2478:"EpCAM in carcinogenesis: the good, the bad or the ugly"
387:
2216:
Biochimica et
Biophysica Acta (BBA) - Reviews on Cancer
1452:
which causes intractable diarrhea in newborn children.
2610:
2608:
552:
727:
positive regulation of cell population proliferation
4627:
4421:
4170:
3854:
3577:
3237:
2835:
1007:
986:
960:
939:
1489:
1487:
1485:
1468:
1466:
1464:
1448:Mutations in EpCAM have also been associated with
334:
233:
2761:GeneReviews/NCBI/NIH/UW entry on Lynch syndrome
615:cadherin binding involved in cell-cell adhesion
2668:Gan to Kagaku Ryoho. Cancer & Chemotherapy
1686:
1684:
1544:
1542:
1494:GRCm38: Ensembl release 89: ENSMUSG00000045394
1313:EpCAM can be cleaved which lends the molecule
732:positive regulation of stem cell proliferation
2804:
8:
2615:Dasgeb B, Mohammadi TM, Mehregan DR (2013).
1781:
1779:
1777:
1473:GRCh38: Ensembl release 89: ENSG00000119888
2811:
2797:
2789:
2779:United States National Library of Medicine
1976:Munz M, Baeuerle PA, Gires O (July 2009).
1872:"EpCAM (CD326) finding its role in cancer"
772:
587:
375:
274:
171:
73:
2828:list of human clusters of differentiation
2768:at the U.S. National Library of Medicine
2718:
2642:
2632:
2588:
2578:
2493:
2452:
2368:
2327:
2317:
2276:
2227:
2186:
2129:
2080:
1993:
1921:
1919:
1917:
1915:
1895:
1803:
1749:
1708:
1664:
1596:
1594:
1574:
1120:potential via its capacity to upregulate
2777:This article incorporates text from the
2210:Fagotto F, Aslemarz A (September 2020).
1433:A problem in EpCAM can indirectly cause
1401:EpCAM is often overexpressed in certain
1388:
717:negative regulation of apoptotic process
2561:Sunjaya AP, Sunjaya AF, Tan ST (2017).
2015:
2013:
1971:
1969:
1967:
1965:
1460:
1870:Baeuerle PA, Gires O (February 2007).
1642:
1640:
503:crypt of lieberkuhn of small intestine
33:
681:integral component of plasma membrane
339:
300:
295:
238:
197:
192:
7:
702:positive regulation of cell motility
499:migratory enteric neural crest cell
1004:
983:
957:
936:
912:
893:
867:
848:
822:
803:
605:protein-containing complex binding
557:
475:
413:
392:
25:
1697:The American Journal of Pathology
1425:, which is an antibody to EpCAM.
1339:epithelial mesenchymal transition
1091:Epithelial cell adhesion molecule
561:
323:
316:
310:
287:
222:
215:
209:
184:
2061:Molecular and Cellular Biology
1829:European Journal of Immunology
1450:congenital tufting enteropathy
1337:EpCAM may also play a role in
631:integral component of membrane
572:More reference expression data
541:More reference expression data
1:
2532:10.1016/S0140-6736(02)09836-7
2445:10.1158/0008-5472.CAN-08-3343
2370:10.1158/0008-5472.CAN-07-0908
2034:10.1016/j.humpath.2003.08.026
1995:10.1158/0008-5472.CAN-09-0654
1928:Journal of Molecular Medicine
1666:10.1158/0008-5472.CAN-04-0754
519:vestibular sensory epithelium
507:epithelium of small intestine
308:
207:
2756:National Institute of Health
2711:10.1053/j.gastro.2008.05.036
2278:10.1016/j.devcel.2013.10.003
1792:Cancer Biology & Therapy
1786:Armstrong A, Eck SL (2003).
1381:are designed to bind to it.
1110:homotypic cellβcell adhesion
4841:Clusters of differentiation
4836:Genes on human chromosome 2
2824:clusters of differentiation
2306:The Journal of Cell Biology
2229:10.1016/j.bbcan.2020.188436
2110:The Journal of Cell Biology
1555:The Journal of Cell Biology
666:basolateral plasma membrane
4857:
2406:10.1016/j.ctrv.2011.04.002
2179:10.1038/s41598-018-31482-7
449:mucosa of transverse colon
29:Transmembrane glycoprotein
1876:British Journal of Cancer
1529:"Mouse PubMed Reference:"
1511:"Human PubMed Reference:"
1196:cells in the same tumor.
1108:mediating Ca-independent
1077:
1072:
1068:
1061:
1045:
1026:
1011:
990:
979:
964:
943:
932:
919:
915:
900:
896:
887:
874:
870:
855:
851:
842:
829:
825:
810:
806:
797:
782:
775:
771:
755:
722:stem cell differentiation
646:bicellular tight junction
590:
586:
569:
560:
551:
538:
527:medullary collecting duct
487:
478:
465:bronchial epithelial cell
425:
416:
386:
378:
374:
357:
344:
307:
286:
277:
273:
256:
243:
206:
183:
174:
170:
125:
122:
112:
105:
100:
81:
76:
59:
54:
49:
45:
41:
36:
2770:Medical Subject Headings
2394:Cancer Treatment Reviews
1354:Target for immunotherapy
1101:among other names, is a
1039:Chr 17: 87.94 β 87.96 Mb
697:ureteric bud development
1252:epidermal growth factor
1221:cell adhesion molecules
1032:Chr 2: 47.35 β 47.39 Mb
636:lateral plasma membrane
437:mucosa of sigmoid colon
2766:TACSTD1+protein,+human
2750:15 August 2007 at the
2567:Journal of Skin Cancer
2122:10.1083/jcb.139.5.1337
1888:10.1038/sj.bjc.6603494
1841:10.1002/eji.1830090817
1751:10.1038/sj.onc.1207610
1398:
1182:gastrointestinal tract
671:apical plasma membrane
2495:10.1093/carcin/bgq187
2319:10.1083/jcb.202211127
2073:10.1128/MCB.18.8.4833
1940:10.1007/s001099900038
1567:10.1083/jcb.125.2.437
1392:
1379:monoclonal antibodies
1349:Clinical significance
1343:short interfering RNA
1235:, and members of the
676:extracellular exosome
302:Chromosome 17 (mouse)
2621:Biomarkers in Cancer
2580:10.1155/2017/2692604
1441:inactivation of the
1419:immunohistochemistry
1415:basal cell carcinoma
1395:basal cell carcinoma
1174:basolateral membrane
200:Chromosome 2 (human)
77:List of PDB id codes
50:Available structures
2171:2018NatSR...813269G
1805:10.4161/cbt.2.4.451
1603:Nature Cell Biology
1276:classic cadherins.
742:leukocyte migration
461:islet of Langerhans
2781:, which is in the
2634:10.4137/BIC.S11856
2265:Developmental Cell
2159:Scientific Reports
1399:
1152:Expression pattern
877:ENSMUSG00000045394
690:Biological process
624:Cellular component
598:Molecular function
4823:
4822:
2312:(1): e202211127.
1429:Genetic disorders
1332:positive feedback
1097:), also known as
1088:
1087:
1084:
1083:
1057:
1056:
1022:
1021:
1001:
1000:
975:
974:
954:
953:
928:
927:
909:
908:
883:
882:
864:
863:
838:
837:
819:
818:
767:
766:
582:
581:
578:
577:
547:
546:
534:
533:
511:intestinal villus
472:
471:
457:corpus epididymis
370:
369:
269:
268:
164:EPCAM - orthologs
96:
95:
92:
91:
60:Ortholog search:
16:(Redirected from
4848:
2813:
2806:
2799:
2790:
2733:
2732:
2722:
2699:Gastroenterology
2690:
2684:
2683:
2663:
2657:
2656:
2646:
2636:
2612:
2603:
2602:
2592:
2582:
2558:
2552:
2551:
2514:
2508:
2507:
2497:
2473:
2467:
2466:
2456:
2424:
2418:
2417:
2389:
2383:
2382:
2372:
2348:
2342:
2341:
2331:
2321:
2297:
2291:
2290:
2280:
2256:
2250:
2249:
2231:
2207:
2201:
2200:
2190:
2150:
2144:
2143:
2133:
2101:
2095:
2094:
2084:
2052:
2046:
2045:
2017:
2008:
2007:
1997:
1973:
1960:
1959:
1923:
1910:
1909:
1899:
1867:
1861:
1860:
1824:
1818:
1817:
1807:
1783:
1772:
1771:
1753:
1729:
1723:
1722:
1712:
1688:
1679:
1678:
1668:
1644:
1635:
1634:
1598:
1589:
1588:
1578:
1546:
1537:
1536:
1525:
1519:
1518:
1507:
1501:
1491:
1480:
1470:
1070:
1069:
1041:
1034:
1017:
1005:
996:
984:
980:RefSeq (protein)
970:
958:
949:
937:
913:
894:
868:
849:
823:
804:
773:
588:
574:
565:
558:
543:
483:
481:Top expressed in
476:
421:
419:Top expressed in
414:
393:
376:
366:
353:
342:
327:
320:
314:
303:
291:
275:
265:
252:
241:
226:
219:
213:
202:
188:
172:
166:
117:
110:
87:
74:
68:
47:
46:
34:
21:
4856:
4855:
4851:
4850:
4849:
4847:
4846:
4845:
4826:
4825:
4824:
4819:
4623:
4417:
4166:
3850:
3573:
3233:
2831:
2817:
2752:Wayback Machine
2741:
2736:
2692:
2691:
2687:
2665:
2664:
2660:
2614:
2613:
2606:
2560:
2559:
2555:
2526:(9334): 671β7.
2516:
2515:
2511:
2488:(11): 1913β21.
2475:
2474:
2470:
2433:Cancer Research
2426:
2425:
2421:
2391:
2390:
2386:
2363:(22): 10831β9.
2357:Cancer Research
2350:
2349:
2345:
2299:
2298:
2294:
2258:
2257:
2253:
2209:
2208:
2204:
2152:
2151:
2147:
2103:
2102:
2098:
2054:
2053:
2049:
2022:Human Pathology
2019:
2018:
2011:
1982:Cancer Research
1975:
1974:
1963:
1934:(10): 699β712.
1925:
1924:
1913:
1869:
1868:
1864:
1826:
1825:
1821:
1785:
1784:
1775:
1744:(34): 5748β58.
1731:
1730:
1726:
1690:
1689:
1682:
1659:(16): 5818β24.
1653:Cancer Research
1646:
1645:
1638:
1615:10.1038/ncb1824
1600:
1599:
1592:
1548:
1547:
1540:
1527:
1526:
1522:
1509:
1508:
1504:
1492:
1483:
1471:
1462:
1458:
1431:
1405:, including in
1387:
1356:
1351:
1311:
1286:complex in the
1273:
1265:
1217:
1209:prostate cancer
1186:small intestine
1154:
1079:View/Edit Mouse
1074:View/Edit Human
1037:
1030:
1027:Location (UCSC)
1013:
992:
966:
945:
858:ENSG00000119888
751:
685:
651:plasma membrane
619:
610:protein binding
570:
539:
530:
525:
521:
517:
513:
509:
505:
501:
497:
493:
479:
468:
463:
459:
455:
451:
447:
443:
439:
435:
433:mucosa of colon
431:
417:
361:
348:
340:
330:
329:
328:
321:
301:
278:Gene location (
260:
247:
239:
229:
228:
227:
220:
198:
175:Gene location (
126:
113:
106:
83:
61:
30:
23:
22:
15:
12:
11:
5:
4854:
4852:
4844:
4843:
4838:
4828:
4827:
4821:
4820:
4818:
4817:
4812:
4807:
4802:
4797:
4792:
4787:
4782:
4777:
4772:
4767:
4762:
4757:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4647:
4642:
4637:
4631:
4629:
4625:
4624:
4622:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4471:
4466:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4425:
4423:
4419:
4418:
4416:
4415:
4410:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4355:
4354:
4349:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4268:
4259:
4254:
4253:
4252:
4247:
4237:
4232:
4231:
4230:
4225:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4174:
4172:
4168:
4167:
4165:
4164:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4078:
4077:
4072:
4062:
4057:
4052:
4047:
4046:
4045:
4040:
4035:
4025:
4020:
4015:
4010:
4005:
4004:
4003:
3998:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3957:
3956:
3951:
3941:
3935:
3930:
3925:
3920:
3911:
3906:
3905:
3904:
3899:
3894:
3884:
3879:
3874:
3869:
3864:
3858:
3856:
3852:
3851:
3849:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3722:
3721:
3716:
3706:
3705:
3704:
3699:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3649:
3644:
3639:
3634:
3629:
3628:
3627:
3622:
3612:
3607:
3602:
3597:
3592:
3587:
3581:
3579:
3575:
3574:
3572:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3522:
3517:
3512:
3507:
3502:
3497:
3496:
3495:
3490:
3485:
3480:
3475:
3470:
3460:
3455:
3450:
3445:
3440:
3435:
3434:
3433:
3428:
3418:
3413:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3377:
3376:
3371:
3366:
3361:
3356:
3351:
3341:
3340:
3339:
3334:
3329:
3319:
3314:
3313:
3312:
3307:
3302:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3241:
3239:
3235:
3234:
3232:
3231:
3226:
3225:
3224:
3219:
3214:
3209:
3204:
3199:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3158:
3157:
3152:
3147:
3142:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3086:
3085:
3080:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2999:
2998:
2993:
2983:
2978:
2973:
2968:
2967:
2966:
2961:
2956:
2951:
2941:
2936:
2931:
2930:
2929:
2919:
2914:
2909:
2904:
2899:
2898:
2897:
2892:
2887:
2877:
2872:
2871:
2870:
2865:
2860:
2855:
2850:
2839:
2837:
2833:
2832:
2818:
2816:
2815:
2808:
2801:
2793:
2774:
2773:
2763:
2758:
2740:
2739:External links
2737:
2735:
2734:
2685:
2658:
2604:
2553:
2509:
2482:Carcinogenesis
2468:
2439:(7): 2887β95.
2419:
2384:
2343:
2292:
2251:
2202:
2145:
2116:(5): 1337β48.
2096:
2067:(8): 4833β43.
2047:
2009:
1988:(14): 5627β9.
1961:
1911:
1862:
1819:
1773:
1724:
1680:
1636:
1590:
1538:
1520:
1502:
1481:
1459:
1457:
1454:
1435:Lynch syndrome
1430:
1427:
1386:
1385:Histopathology
1383:
1355:
1352:
1350:
1347:
1310:
1309:Role in cancer
1307:
1272:
1269:
1264:
1261:
1239:super-family.
1237:immunoglobulin
1216:
1213:
1207:resistance in
1153:
1150:
1086:
1085:
1082:
1081:
1076:
1066:
1065:
1059:
1058:
1055:
1054:
1052:
1050:
1043:
1042:
1035:
1028:
1024:
1023:
1020:
1019:
1009:
1008:
1002:
999:
998:
988:
987:
981:
977:
976:
973:
972:
962:
961:
955:
952:
951:
941:
940:
934:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
881:
880:
872:
871:
865:
862:
861:
853:
852:
846:
840:
839:
836:
835:
827:
826:
820:
817:
816:
808:
807:
801:
795:
794:
789:
784:
780:
779:
769:
768:
765:
764:
753:
752:
750:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
627:
625:
621:
620:
618:
617:
612:
607:
601:
599:
595:
594:
584:
583:
580:
579:
576:
575:
567:
566:
555:
549:
548:
545:
544:
536:
535:
532:
531:
529:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
485:
484:
473:
470:
469:
467:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:jejunal mucosa
426:
423:
422:
410:
409:
401:
390:
384:
383:
380:RNA expression
372:
371:
368:
367:
359:
355:
354:
346:
343:
338:
332:
331:
322:
315:
309:
305:
304:
299:
293:
292:
284:
283:
271:
270:
267:
266:
258:
254:
253:
245:
242:
237:
231:
230:
221:
214:
208:
204:
203:
196:
190:
189:
181:
180:
168:
167:
124:
120:
119:
111:
103:
102:
98:
97:
94:
93:
90:
89:
79:
78:
70:
69:
58:
52:
51:
43:
42:
39:
38:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4853:
4842:
4839:
4837:
4834:
4833:
4831:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4796:
4793:
4791:
4788:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4632:
4630:
4626:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4426:
4424:
4420:
4414:
4411:
4409:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4353:
4350:
4348:
4345:
4344:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4272:
4269:
4267:
4263:
4260:
4258:
4255:
4251:
4248:
4246:
4243:
4242:
4241:
4238:
4236:
4233:
4229:
4226:
4224:
4221:
4220:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4175:
4173:
4169:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4076:
4073:
4071:
4068:
4067:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4002:
3999:
3997:
3994:
3993:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3955:
3952:
3950:
3947:
3946:
3945:
3942:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3915:
3912:
3910:
3907:
3903:
3900:
3898:
3895:
3893:
3890:
3889:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3859:
3857:
3853:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3720:
3717:
3715:
3712:
3711:
3710:
3707:
3703:
3700:
3698:
3695:
3694:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3626:
3623:
3621:
3618:
3617:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3582:
3580:
3576:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3465:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3432:
3429:
3427:
3424:
3423:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3346:
3345:
3342:
3338:
3335:
3333:
3330:
3328:
3325:
3324:
3323:
3320:
3318:
3315:
3311:
3308:
3306:
3303:
3301:
3298:
3297:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3242:
3240:
3236:
3230:
3227:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3194:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3084:
3081:
3079:
3076:
3075:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2997:
2994:
2992:
2989:
2988:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2946:
2945:
2942:
2940:
2937:
2935:
2932:
2928:
2925:
2924:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2896:
2893:
2891:
2888:
2886:
2883:
2882:
2881:
2878:
2876:
2873:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2845:
2844:
2841:
2840:
2838:
2834:
2829:
2825:
2821:
2814:
2809:
2807:
2802:
2800:
2795:
2794:
2791:
2787:
2786:
2784:
2783:public domain
2780:
2771:
2767:
2764:
2762:
2759:
2757:
2753:
2749:
2746:
2745:FAQs on HNPCC
2743:
2742:
2738:
2730:
2726:
2721:
2716:
2712:
2708:
2705:(2): 429β37.
2704:
2700:
2696:
2689:
2686:
2681:
2677:
2673:
2669:
2662:
2659:
2654:
2650:
2645:
2640:
2635:
2630:
2626:
2622:
2618:
2611:
2609:
2605:
2600:
2596:
2591:
2586:
2581:
2576:
2572:
2568:
2564:
2557:
2554:
2549:
2545:
2541:
2537:
2533:
2529:
2525:
2521:
2513:
2510:
2505:
2501:
2496:
2491:
2487:
2483:
2479:
2472:
2469:
2464:
2460:
2455:
2450:
2446:
2442:
2438:
2434:
2430:
2423:
2420:
2415:
2411:
2407:
2403:
2399:
2395:
2388:
2385:
2380:
2376:
2371:
2366:
2362:
2358:
2354:
2347:
2344:
2339:
2335:
2330:
2325:
2320:
2315:
2311:
2307:
2303:
2296:
2293:
2288:
2284:
2279:
2274:
2271:(3): 263β77.
2270:
2266:
2262:
2255:
2252:
2247:
2243:
2239:
2235:
2230:
2225:
2222:(2): 188436.
2221:
2217:
2213:
2206:
2203:
2198:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2149:
2146:
2141:
2137:
2132:
2127:
2123:
2119:
2115:
2111:
2107:
2100:
2097:
2092:
2088:
2083:
2078:
2074:
2070:
2066:
2062:
2058:
2051:
2048:
2043:
2039:
2035:
2031:
2027:
2023:
2016:
2014:
2010:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1972:
1970:
1968:
1966:
1962:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1922:
1920:
1918:
1916:
1912:
1907:
1903:
1898:
1893:
1889:
1885:
1882:(3): 417β23.
1881:
1877:
1873:
1866:
1863:
1858:
1854:
1850:
1846:
1842:
1838:
1834:
1830:
1823:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1782:
1780:
1778:
1774:
1769:
1765:
1761:
1757:
1752:
1747:
1743:
1739:
1735:
1728:
1725:
1720:
1716:
1711:
1706:
1703:(3): 865β75.
1702:
1698:
1694:
1687:
1685:
1681:
1676:
1672:
1667:
1662:
1658:
1654:
1650:
1643:
1641:
1637:
1632:
1628:
1624:
1620:
1616:
1612:
1609:(2): 162β71.
1608:
1604:
1597:
1595:
1591:
1586:
1582:
1577:
1572:
1568:
1564:
1561:(2): 437β46.
1560:
1556:
1552:
1545:
1543:
1539:
1534:
1530:
1524:
1521:
1516:
1512:
1506:
1503:
1499:
1495:
1490:
1488:
1486:
1482:
1478:
1474:
1469:
1467:
1465:
1461:
1455:
1453:
1451:
1446:
1444:
1440:
1436:
1428:
1426:
1424:
1420:
1416:
1412:
1408:
1407:breast cancer
1404:
1396:
1391:
1384:
1382:
1380:
1376:
1372:
1368:
1364:
1362:
1361:immunotherapy
1353:
1348:
1346:
1344:
1340:
1335:
1333:
1329:
1325:
1321:
1316:
1308:
1306:
1303:
1298:
1295:
1291:
1289:
1285:
1280:
1277:
1271:Cell adhesion
1270:
1268:
1262:
1260:
1257:
1256:thyroglobulin
1253:
1249:
1245:
1240:
1238:
1234:
1230:
1226:
1222:
1214:
1212:
1210:
1206:
1202:
1197:
1193:
1191:
1187:
1183:
1179:
1175:
1171:
1167:
1162:
1159:
1151:
1149:
1147:
1143:
1139:
1138:tumorigenesis
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1104:
1103:transmembrane
1100:
1096:
1092:
1080:
1075:
1071:
1067:
1064:
1060:
1053:
1051:
1048:
1044:
1040:
1036:
1033:
1029:
1025:
1018:
1016:
1010:
1006:
1003:
997:
995:
989:
985:
982:
978:
971:
969:
963:
959:
956:
950:
948:
942:
938:
935:
933:RefSeq (mRNA)
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
879:
878:
873:
869:
866:
860:
859:
854:
850:
847:
845:
841:
834:
833:
828:
824:
821:
815:
814:
809:
805:
802:
800:
796:
793:
790:
788:
785:
781:
778:
774:
770:
763:
759:
754:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
694:
692:
689:
688:
682:
679:
677:
674:
672:
669:
667:
664:
662:
661:cell junction
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
628:
626:
623:
622:
616:
613:
611:
608:
606:
603:
602:
600:
597:
596:
593:
592:Gene ontology
589:
585:
573:
568:
564:
559:
556:
554:
550:
542:
537:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
489:
486:
482:
477:
474:
464:
460:
456:
453:renal medulla
452:
448:
444:
440:
436:
432:
428:
427:
424:
420:
415:
412:
411:
408:
406:
402:
400:
399:
395:
394:
391:
389:
385:
381:
377:
373:
365:
360:
356:
352:
347:
341:17|17 E4
337:
333:
326:
319:
313:
306:
298:
294:
290:
285:
281:
276:
272:
264:
259:
255:
251:
246:
236:
232:
225:
218:
212:
205:
201:
195:
191:
187:
182:
178:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
121:
116:
109:
104:
99:
88:
86:
80:
75:
72:
71:
67:
64:
57:
53:
48:
44:
40:
35:
32:
27:
19:
4734:
4341:
4261:
4239:
4217:
4064:
4027:
3990:
3943:
3913:
3886:
3708:
3614:
3462:
3191:
2943:
2776:
2775:
2702:
2698:
2688:
2674:(2): 143β7.
2671:
2667:
2661:
2624:
2620:
2570:
2566:
2556:
2523:
2519:
2512:
2485:
2481:
2471:
2436:
2432:
2422:
2400:(1): 68β75.
2397:
2393:
2387:
2360:
2356:
2346:
2309:
2305:
2295:
2268:
2264:
2254:
2219:
2215:
2205:
2165:(1): 13269.
2162:
2158:
2148:
2113:
2109:
2099:
2064:
2060:
2050:
2028:(1): 122β8.
2025:
2021:
1985:
1981:
1931:
1927:
1879:
1875:
1865:
1835:(8): 657β9.
1832:
1828:
1822:
1798:(4): 320β6.
1795:
1791:
1741:
1737:
1727:
1700:
1696:
1656:
1652:
1606:
1602:
1558:
1554:
1532:
1523:
1514:
1505:
1447:
1432:
1411:colon cancer
1400:
1365:
1357:
1336:
1312:
1301:
1299:
1296:
1292:
1288:cytoskeleton
1281:
1278:
1274:
1266:
1244:glycosylated
1241:
1218:
1198:
1194:
1163:
1155:
1106:glycoprotein
1098:
1094:
1090:
1089:
1012:
991:
965:
944:
920:
901:
875:
856:
830:
811:
791:
786:
656:cell surface
403:
396:
123:External IDs
82:
31:
26:
2573:: 2692604.
1375:nofetumomab
1371:catumaxomab
1367:Edrecolomab
1254:(EGF)- and
1248:amino acids
1242:EpCAM is a
362:87,958,557
349:87,943,407
261:47,387,601
248:47,345,158
101:Identifiers
4830:Categories
2826:(see also
1500:, May 2017
1479:, May 2017
1456:References
1439:epigenetic
1403:carcinomas
1377:and other
1170:stem cells
1166:progenitor
1146:carcinomas
1142:metastasis
491:left colon
407:(ortholog)
144:HomoloGene
2754:from the
2246:221939186
1315:oncogenic
1233:selectins
1229:integrins
1225:cadherins
1223:, namely
1215:Structure
1188:, and in
1161:antigen.
1134:neoplasms
1118:oncogenic
1114:epithelia
1015:NP_032558
994:NP_002345
968:NM_008532
947:NM_002354
777:Orthologs
152:GeneCards
2820:Proteins
2748:Archived
2729:18572020
2680:23411950
2653:24179394
2627:: 7β11.
2599:29464122
2548:42391189
2540:12241873
2504:20837599
2463:19276366
2414:21576002
2379:18006828
2338:36516449
2287:24183651
2238:32976980
2197:30185875
2042:14745734
2004:19584271
1956:13253137
1948:10606205
1906:17211480
1857:28251532
1814:14508099
1768:32348616
1760:15195135
1738:Oncogene
1675:15313925
1623:19136966
1496:–
1475:–
1263:Function
1205:androgen
1178:squamous
1063:Wikidata
756:Sources:
641:membrane
515:duodenum
445:duodenum
4628:301β350
4422:251β300
4374:CD240CE
4171:201β250
3855:151β200
3578:101β150
2720:2574708
2644:3791948
2590:5804366
2454:2664865
2329:9754701
2188:6125409
2167:Bibcode
2140:9382878
2131:2140211
2091:9671492
1897:2360029
1719:8774141
1710:1861708
1631:8616872
1585:8163559
1576:2120036
1498:Ensembl
1477:Ensembl
1328:cyclins
1302:de novo
1284:catenin
1158:antigen
1130:cyclins
889:UniProt
844:Ensembl
783:Species
762:QuickGO
523:utricle
382:pattern
108:Aliases
4635:CD300A
4594:CDw293
4379:CD240D
4240:CD213a
4218:CDw210
4183:CD202b
4157:CDw199
4152:CDw198
3806:CD140b
3238:51β100
2772:(MeSH)
2727:
2717:
2678:
2651:
2641:
2597:
2587:
2546:
2538:
2520:Lancet
2502:
2461:
2451:
2412:
2377:
2336:
2326:
2285:
2244:
2236:
2195:
2185:
2138:
2128:
2089:
2082:109068
2079:
2040:
2002:
1954:
1946:
1904:
1894:
1855:
1849:499332
1847:
1812:
1766:
1758:
1717:
1707:
1673:
1629:
1621:
1583:
1573:
1423:BerEp4
1421:using
1326:, and
1324:e-fabp
1128:, and
1126:e-fabp
1049:search
1047:PubMed
922:Q99JW5
903:P16422
799:Entrez
553:BioGPS
441:rectum
140:106653
132:185535
4815:CD350
4810:CD349
4805:CD344
4800:CD340
4795:CD339
4790:CD338
4785:CD337
4780:CD336
4775:CD335
4770:CD334
4765:CD333
4760:CD332
4755:CD331
4750:CD329
4745:CD328
4740:CD327
4735:CD326
4730:CD325
4725:CD324
4720:CD322
4715:CD321
4710:CD320
4705:CD318
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