1226:(AML), who often show downregulation in NKp30 expression, were incapable of effectively lysing both autologous and allogeneic immature dendritic cells. The ability of NK cells to kill immature dendritic cells may serve to check the quality of dendritic cell maturation process. Interestingly at the same time immunostimulatory capacity of dendritic cells can be enhanced via interaction with NKp30 with ligands expressed on immature dendritic cells. Upon such stimulation NK cells produce
178:
203:
425:
418:
411:
209:
1184:
A8/A9) in contrast to healthy tissue. In addition, interaction of NCR with HS GAGs can facilitate binding to other cellular ligands. Thus via heparan sulfate epitopes NCRs can bind to the same ligands and exert similar reactions and at the same time also have their own unique interacting partners. It
1088:
The distribution of splicing variants of NKp30 varies in tissues and results in different NK cell responses. NKp30a/b engagement stimulates the release of high amounts of IFN-γ, whereas activation of NKp30c induces IL-10 production and only small amounts of IFN-γ. First two are therefore considered
1084:
Six different splicing variants can be found on the cell surface. NKp30a, NKp30b and NKp30c encode molecules with extracellular V-type Ig domain. NKp30d, NKp30e and NKp30f encode extracellular C-type Ig domain. Splicing variants also differ in their cytosolic intracellular domains depending on the
61:
1283:
ENSG00000236979, ENSG00000206430, ENSG00000237808, ENSG00000236315, ENSG00000223833, ENSG00000225211, ENSG00000204475 GRCh38: Ensembl release 89: ENSG00000237103, ENSG00000236979, ENSG00000206430, ENSG00000237808, ENSG00000236315, ENSG00000223833, ENSG00000225211,
1261:. uNK cells express NKp30 and its ligands are expressed by trophoblast cells. Though these ligands have not yet been identified, this interaction has a potential to regulate fetal-maternal interface. The uNK cells dominantly express the inhibitory NKp30c isoform.
1873:
Correia DV, Fogli M, Hudspeth K, da Silva MG, Mavilio D, Silva-Santos B (July 2011). "Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells".
1206:
is another ligand of NKp30. The ligation leads to disruption of the interaction between NKp30 and CD3ζ and thus decreases the activation of NK cells and its cytotoxicity. This is a mechanism of HMCV to evade NK cell surveillance.
2341:
de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH (November 1997). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing".
1089:
as immunostimulatory isoforms which enhance Th1 immune response, while NKp30c mediates immunosuppressive signaling most likely because of reduced association with CD3ζ adaptor after cross-linking with ligand.
1185:
is also known that heparan sulfate epitopes lead to better signaling through growth factor receptors, NCRs could be thus evolved to recognize unusual HS GAGs on malignant cells as transformed cell patterns.
1359:
Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, et al. (October 2001). "Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells".
2457:
Sivakamasundari R, Raghunathan A, Zhang CY, Chowdhury RR, Weissman SM (July 2000). "Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC".
2177:
Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, et al. (September 2006). "Decidual NK cells regulate key developmental processes at the human fetal-maternal interface".
1092:
Gastrointestinal stromal tumor patients who express NKp30c isoform have worse prognosis compared with patients expressing other isoforms, mainly as a consequence of NK cell immunosuppressive character.
1771:
Delahaye NF, Rusakiewicz S, Martins I, Ménard C, Roux S, Lyonnet L, et al. (June 2011). "Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors".
3789:
1980:
Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, et al. (April 2001). "Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis".
2928:
216:
2679:"Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias"
3779:
1062:
2416:"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells"
1494:"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells"
2304:
Holzinger I, de Baey A, Messer G, Kick G, Zwierzina H, Weiss EH (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region".
3759:
2896:
659:
139:
4621:
2945:
2921:
2373:"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC"
1161:
secretion. Direct killing happens similarly to other natural cytotoxicity receptors (NCRs) such as NKp44 and NKp46. NCR3 has a wide range of non-MHC
4352:
1076:. This is a common feature of other NK cell activating receptors as well. Accordingly the cytoplasmic tail lacks typical ITAM consensus sequence.
1662:"Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression"
4340:
4118:
1300:
4404:
4399:
4345:
4125:
2906:
4958:
4953:
3858:
3784:
2914:
4887:
4882:
4877:
4872:
3799:
2497:"Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity"
1214:
express higher levels of NKp30+ NK cells (and its ligation with B7-H6 expressed in salivary glands) in comparison to healthy controls.
2890:
provides an overview of all the structure information available in the PDB for Human
Natural cytotoxicity triggering receptor 3 (NCR3)
2593:"CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity"
1065:
914:
4852:
1395:
4088:
4656:
4150:
3836:
1287:
2784:"Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan"
4295:
3831:
2749:"NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor"
1133:
stimulates the expression of NKp30+ CD8+ T cells with anti-tumor activity. Expression of NKp30 in γδ T cells is induced by
202:
177:
4792:
4264:
4259:
4204:
3938:
3387:
1282:
1189:
1176:
Heparan sulfate epitopes are in healthy tissue as well as on tumor cells, where HS GAGs are changed or differ in ligands (
4486:
4209:
2223:"Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes"
1238:
127:
3804:
2495:
Le
Bouteiller P, Barakonyi A, Giustiniani J, Lenfant F, Marie-Cardine A, Aguerre-Girr M, et al. (December 2002).
1816:"Distinct human circulating NKp30FcεRIγCD8 T cell population exhibiting high natural killer-like antitumor potential"
215:
4516:
2941:
1030:
990:
3382:
208:
4566:
3461:
2881:
2819:"Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site"
1029:
region of the human MHC locus and encodes 190 amino acid long type I transmembrane receptor which belongs to
58:
4963:
4530:
1199:
1110:
1017:
analysis specific monoclonal antibodies reacted with 30kDa molecule, therefore was the protein named NKp30.
732:
728:
724:
714:
710:
706:
702:
698:
3873:
3868:
3863:
3853:
3160:
3088:
2636:"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse"
1223:
1050:
1556:
Kruse PH, Matta J, Ugolini S, Vivier E (March 2014). "Natural cytotoxicity receptors and their ligands".
3217:
3135:
1227:
1222:
Immature dendritic cells can be lysed upon stimulation of NKp30 on NK cells. Accordingly. patients with
1162:
1034:
4454:
4167:
2830:
2591:
Marcenaro E, Augugliaro R, Falco M, Castriconi R, Parolini S, Sivori S, et al. (December 2003).
2508:
2234:
1827:
1102:
1038:
191:
114:
2221:
Siewiera J, Gouilly J, Hocine HR, Cartron G, Levy C, Al-Daccak R, Jabrane-Ferrat N (December 2015).
4481:
4300:
1211:
1106:
874:
870:
821:
817:
559:
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
2714:"Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors"
3888:
3622:
2877:
2622:
2579:
2548:
Augugliaro R, Parolini S, Castriconi R, Marcenaro E, Cantoni C, Nanni M, et al. (May 2003).
2483:
2402:
2329:
2203:
2059:
1814:
Correia MP, Stojanovic A, Bauer K, Juraeva D, Tykocinski LO, Lorenz HM, et al. (June 2018).
1796:
1753:
1581:
1150:
1118:
151:
2414:
Pende D, Parolini S, Pessino A, Sivori S, Augugliaro R, Morelli L, et al. (November 1999).
1492:
Pende D, Parolini S, Pessino A, Sivori S, Augugliaro R, Morelli L, et al. (November 1999).
878:
825:
2858:
2805:
2770:
2735:
2700:
2665:
2614:
2571:
2536:
2475:
2445:
2394:
2359:
2321:
2292:
2260:
2195:
2159:
2110:
2051:
1997:
1957:
1901:
1855:
1788:
1745:
1693:
1639:
1573:
1523:
1463:
1377:
1341:
107:
51:
4661:
4394:
4315:
3878:
3071:
2997:
2848:
2838:
2795:
2760:
2747:
Vitale M, Della Chiesa M, Carlomagno S, Pende D, Aricò M, Moretta L, Moretta A (July 2005).
2725:
2690:
2655:
2647:
2604:
2561:
2526:
2516:
2467:
2435:
2427:
2384:
2351:
2313:
2250:
2242:
2187:
2149:
2141:
2100:
2090:
2041:
2033:
1989:
1947:
1937:
1891:
1883:
1845:
1835:
1780:
1735:
1727:
1683:
1673:
1629:
1621:
1565:
1513:
1505:
1453:
1443:
1369:
1331:
1114:
424:
417:
410:
295:
226:
2283:
Djeu JY, Jiang K, Wei S (March 2002). "A view to a kill: signals triggering cytotoxicity".
4721:
3257:
3252:
3175:
1203:
1166:
1137:
or IL-15. After progesteron stimulation NKp30 can be found on the cytoplasmic membrane of
1122:
1046:
270:
147:
2550:"Selective cross-talk among natural cytotoxicity receptors in human natural killer cells"
2834:
2677:
Nowbakht P, Ionescu MC, Rohner A, Kalberer CP, Rossy E, Mori L, et al. (May 2005).
2512:
2238:
2046:
2021:
1831:
1740:
1715:
4506:
3928:
3439:
3242:
2853:
2818:
2440:
2415:
2255:
2222:
2154:
2129:
2105:
2078:
1952:
1925:
1850:
1815:
1688:
1661:
1634:
1609:
1518:
1493:
1458:
1431:
1193:
1130:
2660:
2635:
2531:
2496:
1926:"Natural cytotoxicity receptors: pattern recognition and involvement of carbohydrates"
1373:
593:
588:
583:
578:
573:
568:
563:
558:
553:
548:
543:
538:
533:
517:
512:
507:
502:
486:
481:
476:
471:
466:
4947:
4476:
3933:
3024:
2900:
2887:
1993:
1134:
1058:
1026:
453:
2626:
2583:
2487:
2406:
2333:
2207:
2063:
1800:
1757:
1585:
1041:
and a 33 amino acid cytoplasmic tail. The Ig-like domain consists of 2 antiparallel
4832:
4140:
4130:
3661:
3627:
1254:
1181:
1170:
1154:
1014:
288:
168:
2634:
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, et al. (December 2003).
1887:
155:
4842:
4491:
4269:
4244:
3943:
3565:
3491:
2965:
2730:
2713:
2389:
2372:
1305:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1258:
1138:
2823:
Proceedings of the
National Academy of Sciences of the United States of America
2800:
2783:
2765:
2748:
2695:
2678:
2501:
Proceedings of the
National Academy of Sciences of the United States of America
1820:
Proceedings of the
National Academy of Sciences of the United States of America
4772:
4496:
4177:
3918:
3794:
3427:
3422:
3417:
3272:
3056:
2037:
1731:
1242:
1042:
185:
135:
2095:
1678:
1448:
4611:
4606:
4601:
4591:
4586:
4581:
4576:
2843:
2431:
1840:
1509:
1250:
623:
388:
309:
254:
241:
143:
118:, 1C7, CD337, LY117, MALS, NKp30, natural cytotoxicity triggering receptor 3
2862:
2809:
2774:
2739:
2704:
2669:
2618:
2575:
2540:
2521:
2479:
2449:
2398:
2355:
2296:
2264:
2199:
2163:
2114:
2055:
2001:
1961:
1905:
1859:
1792:
1749:
1697:
1643:
1577:
1527:
1467:
1381:
1336:
1319:
539:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
2609:
2592:
2566:
2549:
2471:
2363:
2325:
1716:"B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors"
1660:
Pazina T, Shemesh A, Brusilovsky M, Porgador A, Campbell KS (2017-03-30).
1345:
1192:(BAT3) released by tumour cells to extracellular matrix results in NK and
957:
4917:
4817:
4631:
4616:
3819:
3814:
3722:
3412:
1158:
1073:
1054:
1053:
involved in ligand binding. The TM domain contains a positivelly charged
946:
775:
2817:
Joyce MG, Tran P, Zhuravleva MA, Jaw J, Colonna M, Sun PD (April 2011).
2246:
2022:"Virus-mediated inhibition of natural cytotoxicity receptor recognition"
1942:
1714:
Kaifu T, Escalière B, Gastinel LN, Vivier E, Baratin M (November 2011).
1569:
1318:
Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (January 1996).
4867:
4862:
4857:
4757:
4571:
4561:
4388:
4367:
4362:
4330:
4135:
4055:
4050:
4045:
4040:
4035:
3953:
3646:
3486:
3481:
3476:
3471:
3466:
2937:
2651:
2317:
1896:
1069:
975:
761:
688:
2782:
Warren HS, Jones AL, Freeman C, Bettadapura J, Parish CR (July 2005).
1625:
1610:"NKp30 - A prospective target for new cancer immunotherapy strategies"
84:
80:
4807:
4767:
4752:
4736:
4731:
4711:
4706:
4641:
4449:
4419:
4383:
4374:
4187:
4155:
4019:
4014:
3984:
3963:
3923:
3883:
3749:
3727:
3686:
3610:
3605:
3600:
3595:
3590:
3585:
3454:
3449:
3444:
3392:
3377:
3247:
3237:
3200:
3195:
3113:
3108:
2145:
2130:"Uterine NK cells: active regulators at the maternal-fetal interface"
1246:
997:. NCR3 belongs to the family of NCR membrane receptors together with
927:
645:
17:
1784:
1037:
extracellular domain which is 138 amino acids long, a 19 amino acid
2712:
Poggi A, Massaro AM, Negrini S, Contini P, Zocchi MR (March 2005).
2191:
4932:
4907:
4827:
4822:
4812:
4802:
4787:
4782:
4777:
4762:
4716:
4701:
4666:
4651:
4646:
4636:
4556:
4551:
4546:
4525:
4521:
4511:
4424:
4325:
4320:
4279:
4229:
4224:
4219:
4214:
4199:
4192:
4172:
4160:
4103:
4098:
4093:
4083:
4078:
4071:
4009:
3999:
3994:
3989:
3979:
3958:
3948:
3913:
3908:
3903:
3898:
3893:
3848:
3843:
3809:
3774:
3769:
3764:
3754:
3742:
3737:
3717:
3712:
3707:
3702:
3656:
3548:
3543:
3362:
3346:
3339:
3334:
3329:
3324:
3319:
3314:
3289:
3267:
3262:
3155:
3081:
3076:
3066:
1177:
584:
immune response-activating cell surface receptor signaling pathway
1253:
on the maternal-fetal interface. These cells are responsible for
1165:
secreted or expressed by cancer or virus-infected cells, e.g. to
608:
604:
433:
4927:
4922:
4912:
4897:
4892:
4847:
4837:
4797:
4726:
4696:
4691:
4686:
4681:
4676:
4671:
4626:
4596:
4501:
4469:
4464:
4444:
4434:
4429:
4414:
4409:
4310:
4305:
4274:
4254:
4249:
4239:
4234:
4113:
4066:
4026:
3681:
3676:
3671:
3666:
3651:
3642:
3637:
3632:
3617:
3575:
3570:
3560:
3555:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3434:
3407:
3402:
3397:
3372:
3367:
3304:
3299:
3294:
3284:
3279:
3232:
3227:
3222:
3212:
3207:
3190:
3185:
3180:
3170:
3165:
3150:
3145:
3140:
3130:
3125:
3120:
3103:
3098:
3093:
3044:
3012:
3007:
3002:
2985:
2980:
2975:
2970:
1320:"Genes in a 220-kb region spanning the TNF cluster in human MHC"
1126:
1002:
998:
982:
554:
positive regulation of natural killer cell mediated cytotoxicity
131:
2910:
574:
homophilic cell adhesion via plasma membrane adhesion molecules
4439:
3051:
3039:
3034:
3029:
3019:
2992:
2960:
1396:"Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3"
1049:. The extracellular domain contains two potential sites for
569:
susceptibility to natural killer cell mediated cytotoxicity
1432:"The Natural Cytotoxicity Receptors in Health and Disease"
1013:
NKp30 receptor was first identified in 1999. According to
1230:
which is capable of inducing dendritic cell maturation.
1113:
of NK cells. However it is also expressed on surface of
278:
1149:
NKp30 plays a major role in NK anti-tumor response and
400:
1608:
Pinheiro PF, Justino GC, Marques MM (October 2020).
1033:(IgSF). NKp30 has a mass of 30 kDa and includes one
4745:
4539:
4288:
3972:
3695:
3355:
2953:
2020:Seidel E, Glasner A, Mandelboim O (December 2012).
1085:translation of variants of exon 4 (NKp30a,b or c).
892:
863:
839:
810:
1278:
1276:
1274:
1057:residue, which associates with negatively charged
225:
1430:Barrow AD, Martin CJ, Colonna M (2019-05-07).
534:susceptibility to T cell mediated cytotoxicity
2922:
8:
2077:Sojka DK, Yang L, Yokoyama WM (2019-05-01).
1188:Ligation of NKp30 and intracellular protein
2929:
2915:
2907:
2897:United States National Library of Medicine
972:Natural cytotoxicity triggering receptor 3
693:
619:
449:
266:
163:
69:
2946:list of human clusters of differentiation
2880:at the U.S. National Library of Medicine
2852:
2842:
2799:
2764:
2729:
2694:
2659:
2608:
2565:
2530:
2520:
2439:
2388:
2254:
2153:
2104:
2094:
2045:
1951:
1941:
1895:
1849:
1839:
1739:
1687:
1677:
1633:
1517:
1457:
1447:
1335:
2895:This article incorporates text from the
1270:
27:Mammalian protein found in Homo sapiens
2371:Neville MJ, Campbell RD (April 1999).
29:
2134:The Journal of Clinical Investigation
2015:
2013:
2011:
1975:
1973:
1971:
1919:
1917:
1915:
1709:
1707:
1655:
1653:
1425:
513:integral component of plasma membrane
230:
189:
184:
7:
2420:The Journal of Experimental Medicine
2026:Cellular and Molecular Life Sciences
1720:Cellular and Molecular Life Sciences
1603:
1601:
1599:
1597:
1595:
1551:
1549:
1547:
1545:
1543:
1541:
1539:
1537:
1498:The Journal of Experimental Medicine
1487:
1485:
1483:
1481:
1479:
1477:
1423:
1421:
1419:
1417:
1415:
1413:
1411:
1409:
1407:
1405:
985:. NCR3 has also been designated as
1167:heparan sulfate glycosaminoglycans
889:
860:
836:
807:
785:
766:
742:
669:
650:
405:
366:
304:
283:
25:
2128:Moffett A, Colucci F (May 2014).
1374:10.1034/j.1399-0039.2001.580406.x
1025:Gene for NKp30 is located in the
978:that in humans is encoded by the
472:protein homodimerization activity
1994:10.1146/annurev.immunol.19.1.197
423:
416:
409:
214:
207:
201:
176:
1614:British Journal of Pharmacology
1153:, mainly by activating NK cell
1109:and functions as an activating
2597:European Journal of Immunology
2554:European Journal of Immunology
2079:"Uterine Natural Killer Cells"
589:natural killer cell activation
503:integral component of membrane
477:cell adhesion molecule binding
434:More reference expression data
389:More reference expression data
1:
1190:HLA-B-associated transcript 3
579:regulation of immune response
199:
1924:Porgador A (February 2005).
1888:10.1182/blood-2011-02-339135
1257:and vascular remodelling in
1241:(uNK) are the most abundant
1101:NCR3 is expressed mainly on
4959:Clusters of differentiation
4954:Genes on human chromosome 6
2942:clusters of differentiation
2731:10.4049/jimmunol.174.5.2653
2390:10.4049/jimmunol.162.8.4745
1982:Annual Review of Immunology
1558:Immunology and Cell Biology
1031:immunoglobulin super family
4980:
2801:10.4049/jimmunol.175.1.207
2766:10.1182/blood-2004-10-4035
2696:10.1182/blood-2004-07-2585
1141:epithelial cells as well.
991:cluster of differentiation
467:signaling receptor binding
356:mucosa of transverse colon
2038:10.1007/s00018-012-1001-x
1930:TheScientificWorldJournal
1732:10.1007/s00018-011-0802-7
1301:"Human PubMed Reference:"
1218:NKp30 and dendritic cells
1039:transmembrane (TM) domain
961:
956:
952:
945:
926:
909:
896:
867:
856:
843:
814:
803:
792:
788:
773:
769:
760:
749:
745:
722:
696:
687:
676:
672:
657:
653:
644:
629:
622:
618:
602:
487:identical protein binding
452:
448:
431:
408:
399:
386:
373:
369:
316:
307:
277:
269:
265:
248:
235:
198:
175:
166:
162:
125:
122:
112:
105:
100:
77:
72:
55:
50:
45:
41:
37:
32:
2882:Medical Subject Headings
2285:Clinical Cancer Research
2096:10.3389/fimmu.2019.00960
1679:10.3389/fimmu.2017.00369
1449:10.3389/fimmu.2019.00909
2844:10.1073/pnas.1100622108
2432:10.1084/jem.190.10.1505
2083:Frontiers in Immunology
1841:10.1073/pnas.1720564115
1666:Frontiers in Immunology
1510:10.1084/jem.190.10.1505
1436:Frontiers in Immunology
915:Chr 6: 31.59 – 31.59 Mb
2522:10.1073/pnas.012681099
2356:10.1006/geno.1997.4963
1337:10.1006/geno.1996.0034
1224:acute myeloid leukemia
1210:Patients with primary
1051:N-linked glycosylation
56:Human UniProt search:
2788:Journal of Immunology
2718:Journal of Immunology
2610:10.1002/eji.200324425
2567:10.1002/eji.200323896
2472:10.1007/s002510000192
2377:Journal of Immunology
2227:Nature Communications
1234:NCR3 during pregnancy
1200:Human cytomegalovirus
594:immune system process
544:inflammatory response
1103:cytoplasmic membrane
192:Chromosome 6 (human)
73:List of PDB id codes
46:Available structures
2878:NCR3+protein,+human
2835:2011PNAS..108.6223J
2513:2002PNAS...9916963L
2247:10.1038/ncomms10183
2239:2015NatCo...610183S
1943:10.1100/tsw.2005.22
1832:2018PNAS..115E5980C
1826:(26): E5980–E5989.
1570:10.1038/icb.2013.98
2899:, which is in the
2652:10.1101/gr.1736803
2318:10.1007/BF00179392
1212:Sjögren's syndrome
1151:immunosurveillance
1129:. The presence of
527:Biological process
496:Cellular component
460:Molecular function
4941:
4940:
1626:10.1111/bph.15222
1620:(20): 4563–4580.
1080:Splicing variants
969:
968:
965:
964:
941:
940:
905:
904:
886:
885:
852:
851:
833:
832:
799:
798:
782:
781:
756:
755:
739:
738:
683:
682:
666:
665:
614:
613:
444:
443:
440:
439:
395:
394:
382:
381:
363:
362:
261:
260:
96:
95:
92:
91:
16:(Redirected from
4971:
2931:
2924:
2917:
2908:
2866:
2856:
2846:
2813:
2803:
2778:
2768:
2743:
2733:
2708:
2698:
2673:
2663:
2630:
2612:
2587:
2569:
2544:
2534:
2524:
2491:
2453:
2443:
2410:
2392:
2367:
2337:
2300:
2269:
2268:
2258:
2218:
2212:
2211:
2174:
2168:
2167:
2157:
2146:10.1172/JCI68107
2125:
2119:
2118:
2108:
2098:
2074:
2068:
2067:
2049:
2017:
2006:
2005:
1977:
1966:
1965:
1955:
1945:
1921:
1910:
1909:
1899:
1870:
1864:
1863:
1853:
1843:
1811:
1805:
1804:
1768:
1762:
1761:
1743:
1711:
1702:
1701:
1691:
1681:
1657:
1648:
1647:
1637:
1605:
1590:
1589:
1553:
1532:
1531:
1521:
1489:
1472:
1471:
1461:
1451:
1427:
1400:
1399:
1392:
1386:
1385:
1356:
1350:
1349:
1339:
1315:
1309:
1308:
1297:
1291:
1280:
1239:Uterine NK cells
1061:in TM domain of
954:
953:
937:
922:
917:
900:
890:
881:
861:
857:RefSeq (protein)
847:
837:
828:
808:
786:
767:
743:
718:
694:
670:
651:
620:
549:cell recognition
450:
436:
427:
420:
413:
406:
391:
367:
312:
310:Top expressed in
305:
284:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
156:NCR3 - orthologs
117:
110:
87:
70:
64:
43:
42:
30:
21:
4979:
4978:
4974:
4973:
4972:
4970:
4969:
4968:
4944:
4943:
4942:
4937:
4741:
4535:
4284:
3968:
3691:
3351:
2949:
2935:
2874:
2869:
2816:
2781:
2746:
2711:
2676:
2646:(12): 2621–36.
2640:Genome Research
2633:
2603:(12): 3367–76.
2590:
2547:
2507:(26): 16963–8.
2494:
2466:(8–9): 723–32.
2456:
2426:(10): 1505–16.
2413:
2370:
2340:
2303:
2282:
2278:
2276:Further reading
2273:
2272:
2220:
2219:
2215:
2180:Nature Medicine
2176:
2175:
2171:
2127:
2126:
2122:
2076:
2075:
2071:
2032:(23): 3911–20.
2019:
2018:
2009:
1979:
1978:
1969:
1923:
1922:
1913:
1882:(4): 992–1001.
1872:
1871:
1867:
1813:
1812:
1808:
1785:10.1038/nm.2366
1773:Nature Medicine
1770:
1769:
1765:
1713:
1712:
1705:
1659:
1658:
1651:
1607:
1606:
1593:
1555:
1554:
1535:
1504:(10): 1505–16.
1491:
1490:
1475:
1429:
1428:
1403:
1394:
1393:
1389:
1362:Tissue Antigens
1358:
1357:
1353:
1317:
1316:
1312:
1299:
1298:
1294:
1284:ENSG00000204475
1281:
1272:
1267:
1236:
1220:
1147:
1099:
1082:
1047:disulphide bond
1023:
1011:
958:View/Edit Human
935:
920:
913:
910:Location (UCSC)
898:
877:
873:
869:
845:
824:
820:
816:
733:ENSG00000204475
731:
729:ENSG00000225211
727:
725:ENSG00000223833
717:
715:ENSG00000236315
713:
711:ENSG00000237808
709:
707:ENSG00000206430
705:
703:ENSG00000236979
701:
699:ENSG00000237103
697:
598:
564:immune response
522:
508:plasma membrane
491:
482:protein binding
432:
422:
421:
415:
414:
387:
378:
359:
354:
350:
346:
342:
338:
334:
330:
326:
322:
308:
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
126:
113:
106:
79:
57:
28:
23:
22:
15:
12:
11:
5:
4977:
4975:
4967:
4966:
4964:Human proteins
4961:
4956:
4946:
4945:
4939:
4938:
4936:
4935:
4930:
4925:
4920:
4915:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4749:
4747:
4743:
4742:
4740:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4704:
4699:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4543:
4541:
4537:
4536:
4534:
4533:
4528:
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4473:
4472:
4467:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4386:
4377:
4372:
4371:
4370:
4365:
4355:
4350:
4349:
4348:
4343:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4292:
4290:
4286:
4285:
4283:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4196:
4195:
4190:
4180:
4175:
4170:
4165:
4164:
4163:
4158:
4153:
4143:
4138:
4133:
4128:
4123:
4122:
4121:
4116:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4075:
4074:
4069:
4059:
4053:
4048:
4043:
4038:
4029:
4024:
4023:
4022:
4017:
4012:
4002:
3997:
3992:
3987:
3982:
3976:
3974:
3970:
3969:
3967:
3966:
3961:
3956:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3840:
3839:
3834:
3824:
3823:
3822:
3817:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3746:
3745:
3740:
3730:
3725:
3720:
3715:
3710:
3705:
3699:
3697:
3693:
3692:
3690:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3649:
3640:
3635:
3630:
3625:
3620:
3615:
3614:
3613:
3608:
3603:
3598:
3593:
3588:
3578:
3573:
3568:
3563:
3558:
3553:
3552:
3551:
3546:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3495:
3494:
3489:
3484:
3479:
3474:
3469:
3459:
3458:
3457:
3452:
3447:
3437:
3432:
3431:
3430:
3425:
3420:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3359:
3357:
3353:
3352:
3350:
3349:
3344:
3343:
3342:
3337:
3332:
3327:
3322:
3317:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3276:
3275:
3270:
3265:
3260:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3204:
3203:
3198:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3117:
3116:
3111:
3101:
3096:
3091:
3086:
3085:
3084:
3079:
3074:
3069:
3059:
3054:
3049:
3048:
3047:
3037:
3032:
3027:
3022:
3017:
3016:
3015:
3010:
3005:
2995:
2990:
2989:
2988:
2983:
2978:
2973:
2968:
2957:
2955:
2951:
2950:
2936:
2934:
2933:
2926:
2919:
2911:
2892:
2891:
2885:
2873:
2872:External links
2870:
2868:
2867:
2829:(15): 6223–8.
2814:
2779:
2744:
2724:(5): 2653–60.
2709:
2689:(9): 3615–22.
2674:
2631:
2588:
2560:(5): 1235–41.
2545:
2492:
2460:Immunogenetics
2454:
2411:
2383:(8): 4745–54.
2368:
2350:(3): 591–600.
2338:
2306:Immunogenetics
2301:
2279:
2277:
2274:
2271:
2270:
2213:
2192:10.1038/nm1452
2186:(9): 1065–74.
2169:
2120:
2069:
2007:
1988:(1): 197–223.
1967:
1911:
1865:
1806:
1763:
1726:(21): 3531–9.
1703:
1649:
1591:
1533:
1473:
1401:
1387:
1351:
1310:
1292:
1269:
1268:
1266:
1263:
1245:population in
1235:
1232:
1219:
1216:
1194:dendritic cell
1169:(HS GAGs) and
1146:
1143:
1098:
1095:
1081:
1078:
1022:
1019:
1010:
1009:Identification
1007:
967:
966:
963:
962:
960:
950:
949:
943:
942:
939:
938:
933:
931:
924:
923:
918:
911:
907:
906:
903:
902:
894:
893:
887:
884:
883:
865:
864:
858:
854:
853:
850:
849:
841:
840:
834:
831:
830:
812:
811:
805:
801:
800:
797:
796:
790:
789:
783:
780:
779:
771:
770:
764:
758:
757:
754:
753:
747:
746:
740:
737:
736:
720:
719:
691:
685:
684:
681:
680:
674:
673:
667:
664:
663:
655:
654:
648:
642:
641:
636:
631:
627:
626:
616:
615:
612:
611:
600:
599:
597:
596:
591:
586:
581:
576:
571:
566:
561:
556:
551:
546:
541:
536:
530:
528:
524:
523:
521:
520:
515:
510:
505:
499:
497:
493:
492:
490:
489:
484:
479:
474:
469:
463:
461:
457:
456:
446:
445:
442:
441:
438:
437:
429:
428:
403:
397:
396:
393:
392:
384:
383:
380:
379:
377:
374:
371:
370:
364:
361:
360:
358:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
314:
313:
301:
300:
292:
281:
275:
274:
271:RNA expression
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
124:
120:
119:
111:
103:
102:
98:
97:
94:
93:
90:
89:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4976:
4965:
4962:
4960:
4957:
4955:
4952:
4951:
4949:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4750:
4748:
4744:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4544:
4542:
4538:
4532:
4529:
4527:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4471:
4468:
4466:
4463:
4462:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4390:
4387:
4385:
4381:
4378:
4376:
4373:
4369:
4366:
4364:
4361:
4360:
4359:
4356:
4354:
4351:
4347:
4344:
4342:
4339:
4338:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4293:
4291:
4287:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4194:
4191:
4189:
4186:
4185:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4162:
4159:
4157:
4154:
4152:
4149:
4148:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4120:
4117:
4115:
4112:
4111:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4073:
4070:
4068:
4065:
4064:
4063:
4060:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4033:
4030:
4028:
4025:
4021:
4018:
4016:
4013:
4011:
4008:
4007:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3977:
3975:
3971:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3838:
3835:
3833:
3830:
3829:
3828:
3825:
3821:
3818:
3816:
3813:
3812:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3744:
3741:
3739:
3736:
3735:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3700:
3698:
3694:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3583:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3550:
3547:
3545:
3542:
3541:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3464:
3463:
3460:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3441:
3438:
3436:
3433:
3429:
3426:
3424:
3421:
3419:
3416:
3415:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3360:
3358:
3354:
3348:
3345:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3312:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3255:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3202:
3199:
3197:
3194:
3193:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3115:
3112:
3110:
3107:
3106:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3064:
3063:
3060:
3058:
3055:
3053:
3050:
3046:
3043:
3042:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3014:
3011:
3009:
3006:
3004:
3001:
3000:
2999:
2996:
2994:
2991:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2963:
2962:
2959:
2958:
2956:
2952:
2947:
2943:
2939:
2932:
2927:
2925:
2920:
2918:
2913:
2912:
2909:
2905:
2904:
2902:
2901:public domain
2898:
2889:
2886:
2883:
2879:
2876:
2875:
2871:
2864:
2860:
2855:
2850:
2845:
2840:
2836:
2832:
2828:
2824:
2820:
2815:
2811:
2807:
2802:
2797:
2794:(1): 207–12.
2793:
2789:
2785:
2780:
2776:
2772:
2767:
2762:
2759:(2): 566–71.
2758:
2754:
2750:
2745:
2741:
2737:
2732:
2727:
2723:
2719:
2715:
2710:
2706:
2702:
2697:
2692:
2688:
2684:
2680:
2675:
2671:
2667:
2662:
2657:
2653:
2649:
2645:
2641:
2637:
2632:
2628:
2624:
2620:
2616:
2611:
2606:
2602:
2598:
2594:
2589:
2585:
2581:
2577:
2573:
2568:
2563:
2559:
2555:
2551:
2546:
2542:
2538:
2533:
2528:
2523:
2518:
2514:
2510:
2506:
2502:
2498:
2493:
2489:
2485:
2481:
2477:
2473:
2469:
2465:
2461:
2455:
2451:
2447:
2442:
2437:
2433:
2429:
2425:
2421:
2417:
2412:
2408:
2404:
2400:
2396:
2391:
2386:
2382:
2378:
2374:
2369:
2365:
2361:
2357:
2353:
2349:
2345:
2339:
2335:
2331:
2327:
2323:
2319:
2315:
2312:(5): 315–22.
2311:
2307:
2302:
2298:
2294:
2291:(3): 636–40.
2290:
2286:
2281:
2280:
2275:
2266:
2262:
2257:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2217:
2214:
2209:
2205:
2201:
2197:
2193:
2189:
2185:
2181:
2173:
2170:
2165:
2161:
2156:
2151:
2147:
2143:
2140:(5): 1872–9.
2139:
2135:
2131:
2124:
2121:
2116:
2112:
2107:
2102:
2097:
2092:
2088:
2084:
2080:
2073:
2070:
2065:
2061:
2057:
2053:
2048:
2043:
2039:
2035:
2031:
2027:
2023:
2016:
2014:
2012:
2008:
2003:
1999:
1995:
1991:
1987:
1983:
1976:
1974:
1972:
1968:
1963:
1959:
1954:
1949:
1944:
1939:
1935:
1931:
1927:
1920:
1918:
1916:
1912:
1907:
1903:
1898:
1893:
1889:
1885:
1881:
1877:
1869:
1866:
1861:
1857:
1852:
1847:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1810:
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1759:
1755:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1721:
1717:
1710:
1708:
1704:
1699:
1695:
1690:
1685:
1680:
1675:
1671:
1667:
1663:
1656:
1654:
1650:
1645:
1641:
1636:
1631:
1627:
1623:
1619:
1615:
1611:
1604:
1602:
1600:
1598:
1596:
1592:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1552:
1550:
1548:
1546:
1544:
1542:
1540:
1538:
1534:
1529:
1525:
1520:
1515:
1511:
1507:
1503:
1499:
1495:
1488:
1486:
1484:
1482:
1480:
1478:
1474:
1469:
1465:
1460:
1455:
1450:
1445:
1441:
1437:
1433:
1426:
1424:
1422:
1420:
1418:
1416:
1414:
1412:
1410:
1408:
1406:
1402:
1397:
1391:
1388:
1383:
1379:
1375:
1371:
1367:
1363:
1355:
1352:
1347:
1343:
1338:
1333:
1330:(2): 215–22.
1329:
1325:
1321:
1314:
1311:
1306:
1302:
1296:
1293:
1289:
1285:
1279:
1277:
1275:
1271:
1264:
1262:
1260:
1256:
1252:
1248:
1244:
1240:
1233:
1231:
1229:
1225:
1217:
1215:
1213:
1208:
1205:
1201:
1197:
1195:
1191:
1186:
1183:
1179:
1174:
1172:
1168:
1164:
1160:
1156:
1152:
1144:
1142:
1140:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1096:
1094:
1090:
1086:
1079:
1077:
1075:
1071:
1067:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1027:MHC class III
1020:
1018:
1016:
1008:
1006:
1004:
1000:
996:
992:
988:
984:
981:
977:
973:
959:
955:
951:
948:
944:
934:
932:
929:
925:
919:
916:
912:
908:
901:
895:
891:
888:
882:
880:
876:
872:
866:
862:
859:
855:
848:
842:
838:
835:
829:
827:
823:
819:
813:
809:
806:
804:RefSeq (mRNA)
802:
795:
791:
787:
784:
778:
777:
772:
768:
765:
763:
759:
752:
748:
744:
741:
735:
734:
730:
726:
721:
716:
712:
708:
704:
700:
695:
692:
690:
686:
679:
675:
671:
668:
662:
661:
656:
652:
649:
647:
643:
640:
637:
635:
632:
628:
625:
621:
617:
610:
606:
601:
595:
592:
590:
587:
585:
582:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
545:
542:
540:
537:
535:
532:
531:
529:
526:
525:
519:
516:
514:
511:
509:
506:
504:
501:
500:
498:
495:
494:
488:
485:
483:
480:
478:
475:
473:
470:
468:
465:
464:
462:
459:
458:
455:
454:Gene ontology
451:
447:
435:
430:
426:
419:
412:
407:
404:
402:
398:
390:
385:
375:
372:
368:
365:
355:
352:apex of heart
351:
347:
343:
339:
335:
331:
327:
323:
319:
318:
315:
311:
306:
303:
302:
299:
297:
293:
291:
290:
286:
285:
282:
280:
276:
272:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
121:
116:
109:
104:
99:
88:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
4902:
4459:
4379:
4357:
4335:
4182:
4145:
4108:
4061:
4031:
4004:
3826:
3732:
3580:
3309:
3061:
2894:
2893:
2826:
2822:
2791:
2787:
2756:
2752:
2721:
2717:
2686:
2682:
2643:
2639:
2600:
2596:
2557:
2553:
2504:
2500:
2463:
2459:
2423:
2419:
2380:
2376:
2347:
2343:
2309:
2305:
2288:
2284:
2233:(1): 10183.
2230:
2226:
2216:
2183:
2179:
2172:
2137:
2133:
2123:
2086:
2082:
2072:
2029:
2025:
1985:
1981:
1933:
1929:
1879:
1875:
1868:
1823:
1819:
1809:
1779:(6): 700–7.
1776:
1772:
1766:
1723:
1719:
1669:
1665:
1617:
1613:
1564:(3): 221–9.
1561:
1557:
1501:
1497:
1439:
1435:
1390:
1368:(4): 255–8.
1365:
1361:
1354:
1327:
1323:
1313:
1304:
1295:
1255:angiogenesis
1237:
1221:
1209:
1198:
1196:cross-talk.
1187:
1175:
1155:cytotoxicity
1148:
1115:CD8+ T cells
1100:
1091:
1087:
1083:
1045:linked by a
1024:
1015:Western blot
1012:
1001:(NKp46) and
994:
993:337) and as
986:
979:
971:
970:
897:
875:NP_001138939
871:NP_001138938
868:
844:
822:NM_001145467
818:NM_001145466
815:
793:
774:
750:
723:
677:
658:
638:
633:
294:
287:
123:External IDs
78:
1897:2434/223196
1259:trophoblast
1139:endometrial
1043:beta-sheets
344:bone marrow
320:granulocyte
253:31,593,006
240:31,588,895
101:Identifiers
4948:Categories
2944:(see also
1290:, May 2017
1265:References
1243:lymphocyte
1119:γδ T cells
1105:of mature
1097:Expression
1068:molecules
328:lymph node
298:(ortholog)
136:HomoloGene
1936:: 151–4.
1251:pregnancy
1121:with Vδ1
1059:aspartate
1021:Structure
1005:(NKp44).
879:NP_667341
826:NM_147130
624:Orthologs
144:GeneCards
2938:Proteins
2863:21444796
2810:15972650
2775:15784725
2740:15728472
2705:15657183
2670:14656967
2627:40345630
2619:14635045
2584:10724743
2576:12731048
2541:12486241
2488:27714493
2480:10941844
2450:10562324
2407:46517924
2399:10202016
2344:Genomics
2334:19916860
2297:11895890
2265:26666685
2208:19158471
2200:16892062
2164:24789879
2115:31118936
2064:16482529
2056:22547090
2047:11115132
2002:11244035
1962:15759080
1906:21633088
1860:29895693
1801:22671469
1793:21552268
1758:22483622
1750:21877119
1741:11114815
1698:28424697
1644:32737988
1586:38667462
1578:24366519
1528:10562324
1468:31134055
1382:11782277
1324:Genomics
1286:–
1202:protein
1159:cytokine
1145:Function
1111:receptor
1107:NK cells
1055:arginine
947:Wikidata
603:Sources:
518:membrane
348:monocyte
336:appendix
4746:301–350
4540:251–300
4492:CD240CE
4289:201–250
3973:151–200
3696:101–150
2888:PDBe-KB
2854:3076882
2831:Bibcode
2509:Bibcode
2441:2195691
2364:9367684
2326:7590964
2256:4682172
2235:Bibcode
2155:4001528
2106:6504766
2089:: 960.
1953:5936559
1851:6042091
1828:Bibcode
1689:5371597
1672:: 369.
1635:7520444
1519:2195691
1459:6514059
1442:: 909.
1346:8824804
1288:Ensembl
1249:during
1163:ligands
1066:adaptor
1035:Ig-like
976:protein
762:UniProt
689:Ensembl
630:Species
609:QuickGO
273:pattern
232:6p21.33
108:Aliases
4753:CD300A
4712:CDw293
4497:CD240D
4358:CD213a
4336:CDw210
4301:CD202b
4275:CDw199
4270:CDw198
3924:CD140b
3356:51–100
2884:(MeSH)
2861:
2851:
2808:
2773:
2738:
2703:
2668:
2661:403804
2658:
2625:
2617:
2582:
2574:
2539:
2532:139252
2529:
2486:
2478:
2448:
2438:
2405:
2397:
2362:
2332:
2324:
2295:
2263:
2253:
2206:
2198:
2162:
2152:
2113:
2103:
2062:
2054:
2044:
2000:
1960:
1950:
1904:
1858:
1848:
1799:
1791:
1756:
1748:
1738:
1696:
1686:
1642:
1632:
1584:
1576:
1526:
1516:
1466:
1456:
1380:
1344:
1247:uterus
1074:FCεRIγ
930:search
928:PubMed
776:O14931
660:259197
646:Entrez
401:BioGPS
332:spleen
132:611550
4933:CD350
4928:CD349
4923:CD344
4918:CD340
4913:CD339
4908:CD338
4903:CD337
4898:CD336
4893:CD335
4888:CD334
4883:CD333
4878:CD332
4873:CD331
4868:CD329
4863:CD328
4858:CD327
4853:CD326
4848:CD325
4843:CD324
4838:CD322
4833:CD321
4828:CD320
4823:CD318
4818:CD317
4813:CD316
4808:CD315
4803:CD314
4798:CD312
4793:CD309
4788:CD307
4783:CD306
4778:CD305
4773:CD304
4768:CD303
4763:CD302
4758:CD301
4737:CD299
4732:CD298
4727:CD297
4722:CD295
4717:CD294
4707:CD292
4702:CD290
4697:CD289
4692:CD288
4687:CD286
4682:CD284
4677:CD283
4672:CD282
4667:CD281
4662:CD280
4657:CD279
4652:CD278
4647:CD276
4642:CD275
4637:CD274
4632:CD273
4627:CD272
4622:CD271
4617:CD269
4612:CD268
4607:CD267
4602:CD266
4597:CD265
4592:CD264
4587:CD263
4582:CD262
4577:CD261
4572:CD258
4567:CD257
4562:CD256
4557:CD254
4552:CD253
4547:CD252
4531:CD249
4526:CD248
4522:CD247
4517:CD246
4512:CD244
4507:CD243
4502:CD241
4487:CD239
4482:CD238
4477:CD236
4460:CD235
4455:CD234
4450:CD233
4445:CD230
4440:CD229
4435:CD228
4430:CD227
4425:CD226
4420:CD225
4415:CD224
4410:CD223
4405:CD222
4400:CD221
4395:CD220
4380:CD218
4375:CD217
4353:CD212
4331:CD209
4326:CD208
4321:CD207
4316:CD206
4311:CD205
4306:CD204
4296:CD201
4280:CD200
4265:CD197
4260:CD196
4255:CD195
4250:CD194
4245:CD193
4240:CD192
4235:CD191
4230:CD186
4225:CD185
4220:CD184
4215:CD183
4210:CD182
4205:CD181
4200:CD180
4183:CD179
4178:CD178
4173:CD177
4168:CD174
4146:CD172
4141:CD171
4136:CD170
4131:CD169
4126:CD168
4109:CD167
4104:CD166
4099:CD164
4094:CD163
4089:CD162
4084:CD161
4079:CD160
4062:CD159
4032:CD158
4027:CD157
4005:CD156
4000:CD155
3995:CD154
3990:CD153
3985:CD152
3980:CD151
3964:CD150
3959:CD148
3954:CD147
3949:CD146
3944:CD144
3939:CD143
3934:CD142
3929:CD141
3919:CD138
3914:CD137
3909:CD136
3904:CD135
3899:CD134
3894:CD133
3889:CD132
3884:CD131
3879:CD130
3874:CD129
3869:CD127
3864:CD126
3859:CD125
3854:CD124
3849:CD123
3844:CD122
3827:CD121
3810:CD120
3805:CD119
3800:CD118
3795:CD117
3790:CD116
3785:CD115
3780:CD114
3775:CD113
3770:CD112
3765:CD111
3760:CD110
3755:CD109
3750:CD108
3733:CD107
3728:CD106
3723:CD105
3718:CD104
3713:CD103
3708:CD102
3703:CD101
3687:CD100
2753:Blood
2683:Blood
2623:S2CID
2580:S2CID
2484:S2CID
2403:S2CID
2330:S2CID
2204:S2CID
2060:S2CID
1876:Blood
1797:S2CID
1754:S2CID
1582:S2CID
1178:HMGB1
1171:B7-H6
1131:IL-15
995:NKp30
987:CD337
974:is a
639:Mouse
634:Human
605:Amigo
340:gonad
324:blood
296:Mouse
289:Human
236:Start
169:Human
140:51827
18:CD337
3682:CD99
3677:CD98
3672:CD97
3667:CD96
3662:CD95
3657:CD94
3652:CD93
3647:CD92
3643:CD91
3638:CD90
3633:CD89
3628:CD88
3623:CD87
3618:CD86
3581:CD85
3576:CD84
3571:CD83
3566:CD82
3561:CD81
3556:CD80
3539:CD79
3534:CD78
3529:CD74
3524:CD73
3519:CD72
3514:CD71
3509:CD70
3504:CD69
3499:CD68
3462:CD66
3440:CD64
3435:CD63
3413:CD62
3408:CD61
3403:CD59
3398:CD58
3393:CD57
3388:CD56
3383:CD55
3378:CD54
3373:CD53
3368:CD52
3363:CD51
3347:CD50
3310:CD49
3305:CD48
3300:CD47
3295:CD46
3290:CD45
3285:CD44
3280:CD43
3253:CD42
3248:CD41
3243:CD40
3238:CD39
3233:CD38
3228:CD37
3223:CD36
3218:CD35
3213:CD34
3208:CD33
3191:CD32
3186:CD31
3181:CD30
3176:CD29
3171:CD28
3166:CD27
3161:CD26
3156:CD25
3151:CD24
3146:CD23
3141:CD22
3136:CD21
3131:CD20
3126:CD19
3121:CD18
3104:CD16
3099:CD15
3094:CD14
3089:CD13
3062:CD11
3057:CD10
2954:1–50
2859:PMID
2806:PMID
2771:PMID
2736:PMID
2701:PMID
2666:PMID
2615:PMID
2572:PMID
2537:PMID
2476:PMID
2446:PMID
2395:PMID
2360:PMID
2322:PMID
2293:PMID
2261:PMID
2196:PMID
2160:PMID
2111:PMID
2052:PMID
1998:PMID
1958:PMID
1902:PMID
1856:PMID
1789:PMID
1746:PMID
1694:PMID
1640:PMID
1574:PMID
1524:PMID
1464:PMID
1378:PMID
1342:PMID
1228:TNFα
1204:pp65
1182:S100
1157:and
1135:IL-2
1127:ILC2
1125:and
1072:and
1070:CD3ζ
1063:ITAM
1003:NCR2
999:NCR1
983:gene
980:NCR3
279:Bgee
227:Band
186:Chr.
148:NCR3
128:OMIM
115:NCR3
85:3PV6
81:3NOI
62:RCSB
59:PDBe
33:NCR3
3052:CD9
3040:CD8
3035:CD7
3030:CD6
3025:CD5
3020:CD4
2998:CD3
2993:CD2
2966:a-c
2961:CD1
2849:PMC
2839:doi
2827:108
2796:doi
2792:175
2761:doi
2757:106
2726:doi
2722:174
2691:doi
2687:105
2656:PMC
2648:doi
2605:doi
2562:doi
2527:PMC
2517:doi
2468:doi
2436:PMC
2428:doi
2424:190
2385:doi
2381:162
2352:doi
2314:doi
2251:PMC
2243:doi
2188:doi
2150:PMC
2142:doi
2138:124
2101:PMC
2091:doi
2042:PMC
2034:doi
1990:doi
1948:PMC
1938:doi
1892:hdl
1884:doi
1880:118
1846:PMC
1836:doi
1824:115
1781:doi
1736:PMC
1728:doi
1684:PMC
1674:doi
1630:PMC
1622:doi
1618:177
1566:doi
1514:PMC
1506:doi
1502:190
1454:PMC
1444:doi
1370:doi
1332:doi
1123:TCR
936:n/a
921:n/a
899:n/a
846:n/a
794:n/a
751:n/a
678:n/a
376:n/a
249:End
152:OMA
52:PDB
4950::
4524:-
3645:-
2986:1E
2981:1D
2976:1B
2971:1A
2940::
2857:.
2847:.
2837:.
2825:.
2821:.
2804:.
2790:.
2786:.
2769:.
2755:.
2751:.
2734:.
2720:.
2716:.
2699:.
2685:.
2681:.
2664:.
2654:.
2644:13
2642:.
2638:.
2621:.
2613:.
2601:33
2599:.
2595:.
2578:.
2570:.
2558:33
2556:.
2552:.
2535:.
2525:.
2515:.
2505:99
2503:.
2499:.
2482:.
2474:.
2464:51
2462:.
2444:.
2434:.
2422:.
2418:.
2401:.
2393:.
2379:.
2375:.
2358:.
2348:45
2346:.
2328:.
2320:.
2310:42
2308:.
2287:.
2259:.
2249:.
2241:.
2229:.
2225:.
2202:.
2194:.
2184:12
2182:.
2158:.
2148:.
2136:.
2132:.
2109:.
2099:.
2087:10
2085:.
2081:.
2058:.
2050:.
2040:.
2030:69
2028:.
2024:.
2010:^
1996:.
1986:19
1984:.
1970:^
1956:.
1946:.
1932:.
1928:.
1914:^
1900:.
1890:.
1878:.
1854:.
1844:.
1834:.
1822:.
1818:.
1795:.
1787:.
1777:17
1775:.
1752:.
1744:.
1734:.
1724:68
1722:.
1718:.
1706:^
1692:.
1682:.
1668:.
1664:.
1652:^
1638:.
1628:.
1616:.
1612:.
1594:^
1580:.
1572:.
1562:92
1560:.
1536:^
1522:.
1512:.
1500:.
1496:.
1476:^
1462:.
1452:.
1440:10
1438:.
1434:.
1404:^
1376:.
1366:58
1364:.
1340:.
1328:31
1326:.
1322:.
1303:.
1273:^
1180:,
1173:.
1117:,
607:/
255:bp
242:bp
150:;
146::
142:;
138::
134:;
130::
83:,
4470:b
4465:a
4391:)
4389:b
4384:a
4382:(
4368:2
4363:1
4346:b
4341:a
4193:b
4188:a
4161:g
4156:b
4151:a
4119:b
4114:a
4072:c
4067:a
4058:)
4056:k
4051:i
4046:e
4041:d
4036:a
4034:(
4020:c
4015:b
4010:a
3837:b
3832:a
3820:b
3815:a
3743:b
3738:a
3611:k
3606:j
3601:h
3596:e
3591:d
3586:a
3549:b
3544:a
3492:f
3487:e
3482:d
3477:c
3472:b
3467:a
3455:C
3450:B
3445:A
3428:P
3423:L
3418:E
3340:f
3335:e
3330:d
3325:c
3320:b
3315:a
3273:d
3268:c
3263:b
3258:a
3201:B
3196:A
3114:B
3109:A
3082:d
3077:c
3072:b
3067:a
3045:a
3013:ε
3008:δ
3003:γ
2948:)
2930:e
2923:t
2916:v
2903:.
2865:.
2841::
2833::
2812:.
2798::
2777:.
2763::
2742:.
2728::
2707:.
2693::
2672:.
2650::
2629:.
2607::
2586:.
2564::
2543:.
2519::
2511::
2490:.
2470::
2452:.
2430::
2409:.
2387::
2366:.
2354::
2336:.
2316::
2299:.
2289:8
2267:.
2245::
2237::
2231:6
2210:.
2190::
2166:.
2144::
2117:.
2093::
2066:.
2036::
2004:.
1992::
1964:.
1940::
1934:5
1908:.
1894::
1886::
1862:.
1838::
1830::
1803:.
1783::
1760:.
1730::
1700:.
1676::
1670:8
1646:.
1624::
1588:.
1568::
1530:.
1508::
1470:.
1446::
1398:.
1384:.
1372::
1348:.
1334::
1307:.
989:(
171:)
154::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
