242:
219:
116:
141:
493:
248:
147:
1380:
van Spriel AB, de
Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports
980:
family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility. CD37
1610:
Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, van den Brand M, Tzankov A, Visco C, Wang J, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Winter JN, Wang M, Hagemeister FB, Piris MA, Han van
989:
and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms. CD37 controls both humoral and cellular immune responses. CD37-deficiency in mice leads to spontaneous development on B cell lymphoma, and patients with
1560:
de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S, van Houdt IS, Gijbels MJ, van de Loo FA, Bennink MB, Hebeda KM, Groenen PJ, van
Krieken JH, Figdor CG, van Spriel AB (February 2016).
1897:
Wright MD, Rochelle JM, Tomlinson MG, Seldin MF, Williams AF (February 1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication".
1516:
Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, Wright MD (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC".
2153:
Zhao X, Lapalombella R, Joshi T, Cheney C, Gowda A, Hayden-Ledbetter MS, Baum PR, Lin TS, Jarjoura D, Lehman A, Kussewitt D, Lee RJ, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC (October 2007).
1097:
Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes".
3128:
4304:
981:
expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface
2267:
2038:
van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, Knobeloch KP, Plebanski M, Wright MD (March 2004). "A regulatory role for CD37 in T cell proliferation".
1473:
van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, Knobeloch KP, Plebanski M, Wright MD (March 2004). "A regulatory role for CD37 in T cell proliferation".
255:
154:
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Okochi H, Mine T, Nashiro K, Suzuki J, Fujita T, Furue M (July 1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract".
1860:
Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins".
4738:
4798:
3118:
1329:
van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG (March 2009).
1210:
Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web".
4297:
3098:
2235:
671:
77:
4534:
4529:
3960:
2284:
2260:
652:
1931:"Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions"
3691:
2001:
Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils".
4282:
3679:
3457:
1665:
Horejsí V, Vlcek C (August 1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63".
4818:
4290:
3743:
3738:
3684:
3464:
2245:
1079:
4823:
3197:
3123:
2253:
1061:
4501:
4226:
4221:
4216:
4211:
3138:
241:
895:
2214:
4191:
902:
218:
1426:"Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions"
3427:
1819:"The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein"
1153:
3995:
3489:
3175:
1048:
1027:
1613:"Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma"
4506:
3634:
3170:
140:
115:
1044:
4131:
3603:
3598:
3543:
3277:
2726:
2220:
1023:
3825:
3548:
57:
3143:
254:
153:
4489:
3855:
2280:
999:
1424:
Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, Horak I, Orinska Z (August 2000).
2721:
2075:
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004).
247:
146:
3905:
2800:
2207:
1900:
716:
65:
1776:"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen"
1733:"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen"
4770:
3869:
697:
2077:"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions"
3212:
3207:
3202:
3192:
2499:
2427:
2155:"Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical"
4494:
4321:
2556:
2474:
129:
1702:
Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye".
4521:
4477:
4371:
3793:
3506:
2118:
Meyer-Wentrup F, Figdor CG, Ansems M, Brossart P, Wright MD, Adema GJ, van Spriel AB (January 2007).
44:
4511:
3820:
3639:
2226:
976:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the
874:
870:
845:
819:
815:
786:
3227:
2961:
2203:
2063:
2026:
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1406:
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89:
878:
849:
811:
790:
1167:
Levy S, Shoham T (February 2005). "The tetraspanin web modulates immune-signalling complexes".
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2018:
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2166:
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2010:
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309:
85:
1929:
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999).
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3267:
2778:
2581:
2179:
2154:
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1757:
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1502:
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982:
327:
106:
69:
2170:
1628:
1347:
93:
4682:
4544:
4181:
3830:
3608:
3583:
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2904:
2830:
2304:
2051:
1946:
1486:
1084:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1066:
National Center for
Biotechnology Information, U.S. National Library of Medicine
977:
2136:
2119:
1835:
1818:
1331:"The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity"
1245:
Hemler ME (October 2005). "Tetraspanin functions and associated microdomains".
410:
4765:
4748:
4346:
4111:
3835:
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3133:
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2611:
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1394:
226:
123:
73:
1913:
4775:
3950:
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3930:
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3920:
3915:
1731:
Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (September 1990).
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616:
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81:
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1128:
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3955:
3158:
3153:
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2751:
986:
926:
761:
742:
1774:
Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (April 1989).
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4662:
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2815:
2810:
2805:
2276:
2092:
1873:
1817:
Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (February 1988).
1611:
Krieken J, Medeiros LJ, Li Y, van Spriel AB, Young KH (December 2016).
1223:
1110:
958:
728:
683:
2014:
1563:"Tetraspanin CD37 protects against the development of B cell lymphoma"
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4587:
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4562:
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2793:
2788:
2783:
2731:
2716:
2586:
2576:
2539:
2534:
2452:
2447:
2120:"Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production"
1578:
910:
638:
1258:
1180:
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4384:
4271:
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3242:
3237:
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3108:
3103:
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2701:
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2663:
2658:
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2601:
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2420:
2415:
2405:
601:
597:
4785:
4780:
4697:
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4672:
4482:
4379:
4361:
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4236:
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4186:
4176:
4136:
4065:
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4025:
4020:
4015:
4010:
3965:
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3840:
3808:
3803:
3783:
3773:
3768:
3753:
3748:
3649:
3644:
3613:
3593:
3588:
3578:
3573:
3452:
3405:
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3020:
3015:
3010:
3005:
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2909:
2899:
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2837:
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2711:
2706:
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2551:
2546:
2529:
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2519:
2509:
2504:
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2469:
2464:
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2442:
2437:
2432:
2383:
2351:
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2319:
2314:
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965:
61:
4286:
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2378:
2373:
2368:
2358:
2331:
2299:
501:
1288:
van
Deventer SJ, Dunlock VE, van Spriel AB (2017-06-15).
317:
990:
CD37-negative lymphomas have a worse clinical outcome.
482:
1290:"Molecular interactions shaping the tetraspanin web"
4726:
4543:
4520:
4468:
4370:
4337:
4084:
3878:
3627:
3311:
3034:
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2292:
863:
838:
804:
779:
1040:
1038:
1036:
1019:
1017:
1015:
264:
163:
2003:International Archives of Allergy and Immunology
4739:LDL-receptor-related protein-associated protein
1045:GRCm38: Ensembl release 89: ENSMUSG00000030798
4298:
2261:
8:
1024:GRCh38: Ensembl release 89: ENSG00000104894
4305:
4291:
4283:
2268:
2254:
2246:
2236:United States National Library of Medicine
612:
517:
305:
204:
101:
4535:Pulmonary surfactant-associated protein C
4530:Pulmonary surfactant-associated protein B
2285:list of human clusters of differentiation
2206:at the U.S. National Library of Medicine
2178:
2135:
2100:
1954:
1834:
1799:
1756:
1636:
1586:
1449:
1356:
1346:
1305:
1118:
2234:This article incorporates text from the
1148:
1146:
1011:
587:cell surface receptor signaling pathway
16:Mammalian protein found in Homo sapiens
18:
4799:other cell membrane protein disorders
1567:The Journal of Clinical Investigation
1247:Nature Reviews Molecular Cell Biology
556:integral component of plasma membrane
269:
230:
225:
168:
127:
122:
7:
1974:Journal of Clinical Gastroenterology
1780:The Journal of Experimental Medicine
1737:The Journal of Experimental Medicine
4502:Myelin oligodendrocyte glycoprotein
1381:long-lived plasma cell survival".
860:
835:
801:
776:
752:
733:
707:
688:
662:
643:
487:
405:
343:
322:
14:
1154:"Entrez Gene: CD37 CD37 molecule"
961:that in humans is encoded by the
48:, GP52-40, TSPAN26, CD37 molecule
1986:10.1097/00004836-199907000-00016
1442:10.1128/MCB.20.15.5363-5369.2000
1294:Biochemical Society Transactions
491:
253:
246:
240:
217:
152:
145:
139:
114:
4771:Phospholipid transfer proteins
4507:Myelin-associated glycoprotein
1519:European Journal of Immunology
1430:Molecular and Cellular Biology
985:that is known to complex with
551:integral component of membrane
502:More reference expression data
471:More reference expression data
1:
238:
137:
4819:Genes on human chromosome 19
2171:10.1182/blood-2006-12-062927
1679:10.1016/0014-5793(91)80988-F
1629:10.1182/blood-2016-05-715094
1348:10.1371/journal.ppat.1000338
4824:Clusters of differentiation
2281:clusters of differentiation
2052:10.4049/jimmunol.172.5.2953
1487:10.4049/jimmunol.172.5.2953
449:subcutaneous adipose tissue
4840:
4490:Myelin proteolipid protein
2225:gene details page in the
2137:10.4049/jimmunol.178.1.154
1836:10.4049/jimmunol.140.3.905
1169:Nature Reviews. Immunology
1000:Cluster of differentiation
4794:
1947:10.1042/0264-6021:3400103
1395:10.1126/scisignal.2003113
1080:"Mouse PubMed Reference:"
1062:"Human PubMed Reference:"
941:
936:
932:
925:
909:
890:
867:
842:
831:
808:
783:
772:
759:
755:
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736:
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304:
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237:
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186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2208:Medical Subject Headings
1901:International Immunology
896:Chr 19: 49.34 – 49.34 Mb
1935:The Biochemical Journal
1716:10.1242/jcs.114.23.4143
1704:Journal of Cell Science
1212:The Biochemical Journal
903:Chr 7: 44.88 – 44.89 Mb
395:upper lobe of left lung
1914:10.1093/intimm/5.2.209
1792:10.1084/jem.169.4.1497
1749:10.1084/jem.172.3.1007
955:Leukocyte antigen CD37
425:mesenteric lymph nodes
4322:Cell surface receptor
2124:Journal of Immunology
2040:Journal of Immunology
1823:Journal of Immunology
1531:10.1002/eji.200838798
1475:Journal of Immunology
571:immunological synapse
561:extracellular exosome
445:stroma of bone marrow
130:Chromosome 19 (human)
4522:Pulmonary surfactant
4478:Myelin basic protein
4372:Membrane-spanning 4A
2219:genome location and
453:white adipose tissue
232:Chromosome 7 (mouse)
4512:Myelin protein zero
2227:UCSC Genome Browser
2204:CD37+protein,+human
1307:10.1042/BST20160284
271:7 B3|7 29.2 cM
2238:, which is in the
2093:10.1101/gr.2435604
2009:(Suppl 1): 38–44.
1874:10.1007/BF00188787
1710:(Pt 23): 4143–51.
1224:10.1042/BJ20082422
1111:10.1007/BF00222471
717:ENSMUSG00000030798
580:Biological process
544:Cellular component
528:Molecular function
437:tibiofemoral joint
4806:
4805:
4318:membrane proteins
4280:
4279:
2015:10.1159/000053592
1623:(26): 3083–3100.
1383:Science Signaling
952:
951:
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402:
401:
375:bone marrow cells
300:
299:
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4307:
4300:
4293:
4284:
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2263:
2256:
2247:
2192:
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2149:
2139:
2114:
2104:
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1997:
1968:
1958:
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1579:10.1172/JCI81041
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1094:
1088:
1087:
1076:
1070:
1069:
1058:
1052:
1042:
1031:
1021:
934:
933:
905:
898:
881:
861:
852:
836:
832:RefSeq (protein)
822:
802:
793:
777:
753:
734:
708:
689:
663:
644:
613:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:CD37 - orthologs
47:
40:
19:
4839:
4838:
4834:
4833:
4832:
4830:
4829:
4828:
4809:
4808:
4807:
4802:
4790:
4744:Neurofibromin 2
4727:Other/ungrouped
4722:
4539:
4516:
4464:
4366:
4333:
4311:
4281:
4276:
4080:
3874:
3623:
3307:
3030:
2690:
2288:
2274:
2200:
2195:
2152:
2117:
2081:Genome Research
2074:
2037:
2000:
1971:
1928:
1896:
1859:
1816:
1786:(4): 1497–502.
1773:
1730:
1701:
1664:
1660:
1658:Further reading
1655:
1654:
1609:
1608:
1604:
1559:
1558:
1554:
1515:
1514:
1510:
1472:
1471:
1467:
1423:
1422:
1418:
1379:
1378:
1374:
1341:(3): e1000338.
1328:
1327:
1323:
1287:
1286:
1282:
1259:10.1038/nrm1736
1244:
1243:
1239:
1209:
1208:
1204:
1181:10.1038/nri1548
1166:
1165:
1161:
1152:
1151:
1144:
1096:
1095:
1091:
1078:
1077:
1073:
1060:
1059:
1055:
1043:
1034:
1022:
1013:
1008:
996:
974:
943:View/Edit Mouse
938:View/Edit Human
901:
894:
891:Location (UCSC)
877:
873:
869:
848:
844:
818:
814:
810:
789:
785:
698:ENSG00000104894
591:
575:
539:
535:protein binding
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4837:
4835:
4827:
4826:
4821:
4811:
4810:
4804:
4803:
4795:
4792:
4791:
4789:
4788:
4783:
4778:
4773:
4768:
4763:
4762:
4761:
4756:
4746:
4741:
4736:
4730:
4728:
4724:
4723:
4721:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4549:
4547:
4541:
4540:
4538:
4537:
4532:
4526:
4524:
4518:
4517:
4515:
4514:
4509:
4504:
4499:
4498:
4497:
4487:
4486:
4485:
4474:
4472:
4466:
4465:
4463:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4376:
4374:
4368:
4367:
4365:
4364:
4359:
4354:
4349:
4343:
4341:
4335:
4334:
4312:
4310:
4309:
4302:
4295:
4287:
4278:
4277:
4275:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4219:
4214:
4209:
4204:
4199:
4194:
4189:
4184:
4179:
4174:
4169:
4164:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4088:
4086:
4082:
4081:
4079:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3882:
3880:
3876:
3875:
3873:
3872:
3867:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3812:
3811:
3806:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3725:
3716:
3711:
3710:
3709:
3704:
3694:
3689:
3688:
3687:
3682:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3631:
3629:
3625:
3624:
3622:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3535:
3534:
3529:
3519:
3514:
3509:
3504:
3503:
3502:
3497:
3492:
3482:
3477:
3472:
3467:
3462:
3461:
3460:
3455:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3414:
3413:
3408:
3398:
3392:
3387:
3382:
3377:
3368:
3363:
3362:
3361:
3356:
3351:
3341:
3336:
3331:
3326:
3321:
3315:
3313:
3309:
3308:
3306:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3179:
3178:
3173:
3163:
3162:
3161:
3156:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3085:
3084:
3079:
3069:
3064:
3059:
3054:
3049:
3044:
3038:
3036:
3032:
3031:
3029:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2993:
2988:
2979:
2974:
2969:
2964:
2959:
2954:
2953:
2952:
2947:
2942:
2937:
2932:
2927:
2917:
2912:
2907:
2902:
2897:
2892:
2891:
2890:
2885:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2834:
2833:
2828:
2823:
2818:
2813:
2808:
2798:
2797:
2796:
2791:
2786:
2776:
2771:
2770:
2769:
2764:
2759:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2698:
2696:
2692:
2691:
2689:
2688:
2683:
2682:
2681:
2676:
2671:
2666:
2661:
2656:
2646:
2641:
2636:
2631:
2626:
2621:
2616:
2615:
2614:
2609:
2604:
2599:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2543:
2542:
2537:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2456:
2455:
2450:
2440:
2435:
2430:
2425:
2424:
2423:
2418:
2413:
2408:
2398:
2393:
2388:
2387:
2386:
2376:
2371:
2366:
2361:
2356:
2355:
2354:
2349:
2344:
2334:
2329:
2328:
2327:
2322:
2317:
2312:
2307:
2296:
2294:
2290:
2289:
2275:
2273:
2272:
2265:
2258:
2250:
2231:
2230:
2211:
2199:
2198:External links
2196:
2194:
2193:
2165:(7): 2569–77.
2150:
2115:
2072:
2046:(5): 2953–61.
2035:
1998:
1969:
1926:
1894:
1862:Immunogenetics
1857:
1814:
1771:
1728:
1699:
1661:
1659:
1656:
1653:
1652:
1602:
1552:
1508:
1481:(5): 2953–61.
1465:
1436:(15): 5363–9.
1416:
1372:
1335:PLOS Pathogens
1321:
1300:(3): 741–750.
1280:
1253:(10): 801–11.
1237:
1202:
1159:
1142:
1099:Immunogenetics
1089:
1071:
1053:
1032:
1010:
1009:
1007:
1004:
1003:
1002:
995:
992:
973:
970:
950:
949:
946:
945:
940:
930:
929:
923:
922:
919:
918:
916:
914:
907:
906:
899:
892:
888:
887:
884:
883:
865:
864:
858:
855:
854:
840:
839:
833:
829:
828:
825:
824:
806:
805:
799:
796:
795:
781:
780:
774:
770:
769:
766:
765:
757:
756:
750:
747:
746:
738:
737:
731:
725:
724:
721:
720:
712:
711:
705:
702:
701:
693:
692:
686:
680:
679:
676:
675:
667:
666:
660:
657:
656:
648:
647:
641:
635:
634:
629:
624:
620:
619:
609:
608:
605:
604:
593:
592:
590:
589:
583:
581:
577:
576:
574:
573:
568:
563:
558:
553:
547:
545:
541:
540:
538:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4836:
4825:
4822:
4820:
4817:
4816:
4814:
4801:
4800:
4793:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4760:
4757:
4755:
4752:
4751:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4731:
4729:
4725:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4550:
4548:
4546:
4542:
4536:
4533:
4531:
4528:
4527:
4525:
4523:
4519:
4513:
4510:
4508:
4505:
4503:
4500:
4496:
4493:
4492:
4491:
4488:
4484:
4481:
4480:
4479:
4476:
4475:
4473:
4471:
4467:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4377:
4375:
4373:
4369:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4344:
4342:
4340:
4336:
4331:
4327:
4323:
4319:
4315:
4308:
4303:
4301:
4296:
4294:
4289:
4288:
4285:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4228:
4225:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4089:
4087:
4083:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3883:
3881:
3877:
3871:
3868:
3866:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3810:
3807:
3805:
3802:
3801:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3729:
3726:
3724:
3720:
3717:
3715:
3712:
3708:
3705:
3703:
3700:
3699:
3698:
3695:
3693:
3690:
3686:
3683:
3681:
3678:
3677:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3632:
3630:
3626:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3533:
3530:
3528:
3525:
3524:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3501:
3498:
3496:
3493:
3491:
3488:
3487:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3459:
3456:
3454:
3451:
3450:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3412:
3409:
3407:
3404:
3403:
3402:
3399:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3372:
3369:
3367:
3364:
3360:
3357:
3355:
3352:
3350:
3347:
3346:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3316:
3314:
3310:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3177:
3174:
3172:
3169:
3168:
3167:
3164:
3160:
3157:
3155:
3152:
3151:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3083:
3080:
3078:
3075:
3074:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3039:
3037:
3033:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2922:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2889:
2886:
2884:
2881:
2880:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2803:
2802:
2799:
2795:
2792:
2790:
2787:
2785:
2782:
2781:
2780:
2777:
2775:
2772:
2768:
2765:
2763:
2760:
2758:
2755:
2754:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2699:
2697:
2693:
2687:
2684:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2651:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2594:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2541:
2538:
2536:
2533:
2532:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2454:
2451:
2449:
2446:
2445:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2403:
2402:
2399:
2397:
2394:
2392:
2389:
2385:
2382:
2381:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2353:
2350:
2348:
2345:
2343:
2340:
2339:
2338:
2335:
2333:
2330:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2302:
2301:
2298:
2297:
2295:
2291:
2286:
2282:
2278:
2271:
2266:
2264:
2259:
2257:
2252:
2251:
2248:
2244:
2243:
2241:
2240:public domain
2237:
2228:
2224:
2223:
2218:
2217:
2212:
2209:
2205:
2202:
2201:
2197:
2190:
2186:
2181:
2176:
2172:
2168:
2164:
2160:
2156:
2151:
2147:
2143:
2138:
2133:
2130:(1): 154–62.
2129:
2125:
2121:
2116:
2112:
2108:
2103:
2098:
2094:
2090:
2087:(9): 1711–8.
2086:
2082:
2078:
2073:
2069:
2065:
2061:
2057:
2053:
2049:
2045:
2041:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2008:
2004:
1999:
1995:
1991:
1987:
1983:
1979:
1975:
1970:
1966:
1962:
1957:
1952:
1948:
1944:
1941:(1): 103–11.
1940:
1936:
1932:
1927:
1923:
1919:
1915:
1911:
1908:(2): 209–16.
1907:
1903:
1902:
1895:
1891:
1887:
1883:
1879:
1875:
1871:
1868:(4): 249–56.
1867:
1863:
1858:
1854:
1850:
1846:
1842:
1837:
1832:
1829:(3): 905–14.
1828:
1824:
1820:
1815:
1811:
1807:
1802:
1797:
1793:
1789:
1785:
1781:
1777:
1772:
1768:
1764:
1759:
1754:
1750:
1746:
1742:
1738:
1734:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1663:
1662:
1657:
1648:
1644:
1639:
1634:
1630:
1626:
1622:
1618:
1614:
1606:
1603:
1598:
1594:
1589:
1584:
1580:
1576:
1573:(2): 653–66.
1572:
1568:
1564:
1556:
1553:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1512:
1509:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1469:
1466:
1461:
1457:
1452:
1447:
1443:
1439:
1435:
1431:
1427:
1420:
1417:
1412:
1408:
1404:
1400:
1396:
1392:
1389:(250): ra82.
1388:
1384:
1376:
1373:
1368:
1364:
1359:
1354:
1349:
1344:
1340:
1336:
1332:
1325:
1322:
1317:
1313:
1308:
1303:
1299:
1295:
1291:
1284:
1281:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1241:
1238:
1233:
1229:
1225:
1221:
1218:(2): 133–54.
1217:
1213:
1206:
1203:
1198:
1194:
1190:
1186:
1182:
1178:
1175:(2): 136–48.
1174:
1170:
1163:
1160:
1155:
1149:
1147:
1143:
1138:
1134:
1130:
1126:
1121:
1116:
1112:
1108:
1104:
1100:
1093:
1090:
1085:
1081:
1075:
1072:
1067:
1063:
1057:
1054:
1050:
1046:
1041:
1039:
1037:
1033:
1029:
1025:
1020:
1018:
1016:
1012:
1005:
1001:
998:
997:
993:
991:
988:
984:
979:
971:
969:
967:
964:
960:
956:
944:
939:
935:
931:
928:
924:
917:
915:
912:
908:
904:
900:
897:
893:
889:
882:
880:
876:
872:
866:
862:
859:
853:
851:
847:
841:
837:
834:
830:
823:
821:
817:
813:
807:
803:
800:
794:
792:
788:
782:
778:
775:
773:RefSeq (mRNA)
771:
764:
763:
758:
754:
751:
745:
744:
739:
735:
732:
730:
726:
719:
718:
713:
709:
706:
700:
699:
694:
690:
687:
685:
681:
674:
673:
668:
664:
661:
655:
654:
649:
645:
642:
640:
636:
633:
630:
628:
625:
621:
618:
614:
610:
603:
599:
594:
588:
585:
584:
582:
579:
578:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
548:
546:
543:
542:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4796:
4677:
4330:cytoskeleton
4320:(other than
3798:
3718:
3696:
3674:
3521:
3484:
3447:
3400:
3370:
3343:
3165:
3071:
2919:
2648:
2566:
2400:
2233:
2232:
2221:
2215:
2162:
2158:
2127:
2123:
2084:
2080:
2043:
2039:
2006:
2002:
1977:
1973:
1938:
1934:
1905:
1899:
1865:
1861:
1826:
1822:
1783:
1779:
1740:
1736:
1707:
1703:
1673:(1–2): 1–4.
1670:
1667:FEBS Letters
1666:
1620:
1616:
1605:
1570:
1566:
1555:
1522:
1518:
1511:
1478:
1474:
1468:
1433:
1429:
1419:
1386:
1382:
1375:
1338:
1334:
1324:
1297:
1293:
1283:
1250:
1246:
1240:
1215:
1211:
1205:
1172:
1168:
1162:
1120:10138/157839
1105:(6): 461–5.
1102:
1098:
1092:
1083:
1074:
1065:
1056:
983:glycoprotein
975:
962:
954:
953:
875:NP_001277733
871:NP_001277731
868:
846:NP_001035120
843:
820:NM_001290804
816:NM_001290802
809:
787:NM_001040031
784:
760:
741:
715:
696:
670:
651:
631:
626:
333:
326:
53:External IDs
4545:Tetraspanin
1980:(1): 63–7.
1743:(3): 1007.
1525:(1): 50–5.
978:tetraspanin
421:granulocyte
391:gallbladder
359:granulocyte
292:44,888,539
279:44,883,056
191:49,343,335
178:49,335,171
31:Identifiers
4813:Categories
4749:Presenilin
2283:(see also
1051:, May 2017
1030:, May 2017
1006:References
387:right lung
383:lymph node
337:(ortholog)
74:HomoloGene
4797:see also
4776:Dysferlin
987:integrins
879:NP_031671
850:NP_001765
812:NM_007645
791:NM_001774
617:Orthologs
82:GeneCards
4734:Calnexin
4339:Arrestin
2277:Proteins
2189:17440052
2146:17182550
2111:15342556
2060:14978098
2031:39289159
2023:10529602
1994:10405235
1965:10229664
1890:20252327
1853:23948434
1724:11739647
1695:26316623
1647:27760757
1597:26784544
1547:46297687
1539:19089816
1495:14978098
1460:10891477
1411:21237789
1403:23150881
1367:19282981
1316:28620035
1267:16314869
1232:19426143
1189:15688041
1047:–
1026:–
994:See also
972:Function
927:Wikidata
596:Sources:
566:membrane
371:appendix
363:monocyte
170:19q13.33
4718:TSPAN34
4713:TSPAN33
4708:TSPAN32
4703:TSPAN31
4698:TSPAN30
4693:TSPAN29
4688:TSPAN28
4683:TSPAN27
4678:TSPAN26
4673:TSPAN25
4668:TSPAN24
4663:TSPAN23
4658:TSPAN22
4653:TSPAN21
4648:TSPAN20
4643:TSPAN19
4638:TSPAN18
4633:TSPAN17
4628:TSPAN16
4623:TSPAN15
4618:TSPAN14
4613:TSPAN13
4608:TSPAN12
4603:TSPAN11
4598:TSPAN10
4326:enzymes
4316:: cell
4314:Protein
4085:301–350
3879:251–300
3831:CD240CE
3628:201–250
3312:151–200
3035:101–150
2180:1988922
2068:5620186
1956:1220227
1922:8452817
1882:8119731
1845:3257508
1810:2466944
1801:2189247
1767:2388030
1758:2188538
1687:1879540
1638:5201094
1588:4731177
1503:5620186
1358:2650281
1275:5906694
1197:1756810
1137:8899453
1129:8436422
1049:Ensembl
1028:Ensembl
959:protein
729:UniProt
684:Ensembl
623:Species
602:QuickGO
312:pattern
38:Aliases
4593:TSPAN9
4588:TSPAN8
4583:TSPAN7
4578:TSPAN6
4573:TSPAN5
4568:TSPAN4
4563:TSPAN3
4558:TSPAN2
4553:TSPAN1
4470:Myelin
4460:MS4A18
4455:MS4A15
4450:MS4A14
4445:MS4A13
4440:MS4A12
4435:MS4A10
4425:MS4A8B
4415:MS4A6E
4410:MS4A6A
4400:MS4A4E
4395:MS4A4A
4328:, and
4092:CD300A
4051:CDw293
3836:CD240D
3697:CD213a
3675:CDw210
3640:CD202b
3614:CDw199
3609:CDw198
3263:CD140b
2695:51–100
2213:Human
2210:(MeSH)
2187:
2177:
2144:
2109:
2102:515316
2099:
2066:
2058:
2029:
2021:
1992:
1963:
1953:
1920:
1888:
1880:
1851:
1843:
1808:
1798:
1765:
1755:
1722:
1693:
1685:
1645:
1635:
1595:
1585:
1545:
1537:
1501:
1493:
1458:
1448:
1409:
1401:
1365:
1355:
1314:
1273:
1265:
1230:
1195:
1187:
1135:
1127:
913:search
911:PubMed
762:Q61470
743:P11049
639:Entrez
483:BioGPS
457:embryo
441:thymus
429:spleen
367:spleen
62:151523
4759:PSEN2
4754:PSEN1
4430:MS4A9
4420:MS4A7
4405:MS4A5
4390:MS4A3
4385:MS4A2
4380:MS4A1
4357:ARRB2
4352:ARRB1
4272:CD350
4267:CD349
4262:CD344
4257:CD340
4252:CD339
4247:CD338
4242:CD337
4237:CD336
4232:CD335
4227:CD334
4222:CD333
4217:CD332
4212:CD331
4207:CD329
4202:CD328
4197:CD327
4192:CD326
4187:CD325
4182:CD324
4177:CD322
4172:CD321
4167:CD320
4162:CD318
4157:CD317
4152:CD316
4147:CD315
4142:CD314
4137:CD312
4132:CD309
4127:CD307
4122:CD306
4117:CD305
4112:CD304
4107:CD303
4102:CD302
4097:CD301
4076:CD299
4071:CD298
4066:CD297
4061:CD295
4056:CD294
4046:CD292
4041:CD290
4036:CD289
4031:CD288
4026:CD286
4021:CD284
4016:CD283
4011:CD282
4006:CD281
4001:CD280
3996:CD279
3991:CD278
3986:CD276
3981:CD275
3976:CD274
3971:CD273
3966:CD272
3961:CD271
3956:CD269
3951:CD268
3946:CD267
3941:CD266
3936:CD265
3931:CD264
3926:CD263
3921:CD262
3916:CD261
3911:CD258
3906:CD257
3901:CD256
3896:CD254
3891:CD253
3886:CD252
3870:CD249
3865:CD248
3861:CD247
3856:CD246
3851:CD244
3846:CD243
3841:CD241
3826:CD239
3821:CD238
3816:CD236
3799:CD235
3794:CD234
3789:CD233
3784:CD230
3779:CD229
3774:CD228
3769:CD227
3764:CD226
3759:CD225
3754:CD224
3749:CD223
3744:CD222
3739:CD221
3734:CD220
3719:CD218
3714:CD217
3692:CD212
3670:CD209
3665:CD208
3660:CD207
3655:CD206
3650:CD205
3645:CD204
3635:CD201
3619:CD200
3604:CD197
3599:CD196
3594:CD195
3589:CD194
3584:CD193
3579:CD192
3574:CD191
3569:CD186
3564:CD185
3559:CD184
3554:CD183
3549:CD182
3544:CD181
3539:CD180
3522:CD179
3517:CD178
3512:CD177
3507:CD174
3485:CD172
3480:CD171
3475:CD170
3470:CD169
3465:CD168
3448:CD167
3443:CD166
3438:CD164
3433:CD163
3428:CD162
3423:CD161
3418:CD160
3401:CD159
3371:CD158
3366:CD157
3344:CD156
3339:CD155
3334:CD154
3329:CD153
3324:CD152
3319:CD151
3303:CD150
3298:CD148
3293:CD147
3288:CD146
3283:CD144
3278:CD143
3273:CD142
3268:CD141
3258:CD138
3253:CD137
3248:CD136
3243:CD135
3238:CD134
3233:CD133
3228:CD132
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