384:
361:
258:
283:
2712:
649:
642:
635:
2697:
390:
289:
95:
36:
1480:, producing a massive protein with extracellular and cytoplasmic domains that are both unusually large. Exons 4, 5, and 6 (corresponding to protein regions A, B, and C) are alternatively spliced to generate up to eight different protein products featuring combinations of zero, one, two, or all three exons.
1619:
background to be a perfect congenic strain. This mouse, dubbed the CD45.1STEM mouse, differs from the C57BL/6 strain by a single base pair resulting in a single amino acid change that confers the difference in reactivity by the anti-CD45.1 and anti-CD45.2 antibodies. This strain was designed for
1502:
CD45R (also known as CD45RABC) contains all three possible exons. It is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220 (B cell isoform of 220 kDa).
121:
1498:
Naive T lymphocytes are typically positive for CD45RA, which includes only the A protein region. Activated and memory T lymphocytes express CD45RO, the shortest CD45 isoform, which lacks all three of the A, B, and C regions. This shortest isoform facilitates T cell activation.
1599:
of CD45 in mice: CD45.1 (Ly5.1 historically) and CD45.2 (Ly5.2 historically). These two types of CD45 are believed to be functionally identical. As such, they are routinely used in scientific research to allow identification of cells. For instance,
1494:
CD45 isoforms show cell-type and differentiation-stage specific expression, a pattern which is quite well conserved in mammals. These isoforms are often used as markers that identify and distinguish between different types of immune cells.
2539:
Stanton T, Boxall S, Bennett A, Kaleebu P, Watera C, Whitworth J, et al. (May 2004). "CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive
Ugandans".
1370:, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for
1604:
can be transferred from a CD45.1 donor mouse, into a CD45.2 host mouse, and can be subsequently identified due to their expression of CD45.1. This technique is also routinely used when generating
3613:
4789:
2752:
1483:
CD45's large extracellular domain is highly glycosylated, and these eight isoforms allow wide variation in the structure of its side chains. The isoforms affect the protein's
2711:
54:
397:
296:
1354:
PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated
1620:
competitive bone marrow transplantation assays and demonstrated perfect equivalence, unlike the previous standard, the "SJL" mouse, more formally known as Pep Boy.
1560:
CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with
1995:"Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction"
3603:
2502:
Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Otsuyama K, et al. (September 2003). "Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation".
4782:
2353:
3583:
2696:
1007:
988:
219:
4445:
2769:
2745:
1564:
on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to
2405:"Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse"
1429:
signalling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of
1579:
the CD45 of healthy cells, among other cell markers, to be immune to a treatment that kills all normal CD45 cells, including the cancerous ones. An
4176:
1938:
1584:
4775:
4164:
3942:
4228:
4223:
4169:
3949:
2730:
2676:
1717:"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain"
1697:
190:, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
2249:"The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells"
1679:
1394:
cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic
5558:
5553:
3682:
3608:
2738:
1552:. In addition, CD45 was shown to be the target of the species D adenovirus 19a E3/49K protein to inhibit the activation of NK and T cells.
2036:"Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45"
118:
4711:
4706:
4701:
4696:
3623:
1583:
exists that kills specifically cells with unaltered CD45, and "shielded" cells with modified CD45 have been developed that evade this.
1255:
383:
1262:
4676:
1922:
72:
360:
3912:
1777:
1390:(PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
4480:
3974:
3660:
2378:
1666:
1645:
4119:
3655:
1587:
would be used to replace the original healthy blood cells with modified stem cells, and then the treatment would be applied.
1662:
1954:"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II"
1476:
The CD45 protein family consists of multiple members that are all products of a single complex gene. This gene contains 34
282:
257:
4831:
4616:
4088:
4083:
4028:
3762:
3211:
1641:
5509:
5474:
5456:
5051:
4815:
4802:
4310:
4033:
1406:
1387:
199:
2607:
1580:
3628:
2300:"A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions"
1512:
396:
295:
4340:
2765:
1340:
2077:"Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45"
1448:
Many alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
389:
288:
3206:
2669:
4806:
4390:
3285:
1056:
207:
4354:
1426:
1422:
1037:
1033:
2118:"CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line"
3697:
3692:
3687:
3677:
2984:
2912:
1794:
Hermiston ML, Xu Z, Weiss A (2003). "CD45: a critical regulator of signaling thresholds in immune cells".
1565:
1575:
Therapies for blood cancer, including acute myeloid leukemia, have been proposed based on the concept of
4767:
3041:
2959:
2577:
Huntington ND, Tarlinton DM (July 2004). "CD45: direct and indirect government of immune regulation".
4278:
3991:
2662:
1728:
1457:
1453:
271:
186:
4305:
4124:
1612:(Thy1) alleles, which CD90.1/CD90.2 system is used in the same manner as the CD45.1/CD45.2 system.
1576:
1234:
1230:
1193:
1163:
1159:
1126:
2247:
Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, et al. (December 2011).
2159:"Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro"
1209:
1205:
5312:
3712:
3446:
2565:
2527:
2298:
Windheim M, Southcombe JH, Kremmer E, Chaplin L, Urlaub D, Falk CS, et al. (December 2013).
1605:
1355:
231:
5345:
1238:
1201:
1197:
1167:
1138:
1134:
1130:
2634:
2594:
2557:
2519:
2490:
2434:
2329:
2280:
2229:
2180:
2139:
2098:
2057:
2016:
1975:
1918:
1895:
1846:
1811:
1756:
1434:
1399:
648:
641:
179:
111:
5242:
5237:
5206:
5123:
1807:
1437:
required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses
5438:
5428:
5418:
5413:
5292:
5287:
5282:
5267:
5247:
5227:
5064:
5020:
4939:
4485:
4218:
4139:
3702:
2895:
2821:
2586:
2549:
2511:
2424:
2416:
2319:
2311:
2270:
2260:
2219:
2211:
2170:
2129:
2088:
2047:
2006:
1965:
1885:
1877:
1838:
1803:
1746:
1736:
1395:
476:
407:
351:
306:
5403:
5398:
5388:
5383:
5302:
5108:
2200:"SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription"
634:
227:
5527:
5335:
4545:
3081:
3076:
2999:
1488:
1371:
451:
1842:
1732:
5368:
4330:
3752:
3263:
3066:
2429:
2404:
2324:
2299:
2275:
2248:
1890:
1865:
1715:
Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. (September 1990).
1430:
94:
2720:: Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide
2224:
2199:
2134:
2117:
2093:
2076:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
720:
715:
710:
705:
700:
695:
690:
5547:
4300:
3757:
2848:
2643:
1881:
1751:
1716:
1410:
677:
2569:
2531:
2382:
2215:
5360:
4656:
3964:
3954:
3485:
3451:
1438:
1418:
1414:
469:
248:
211:
2420:
2265:
1456:
to differentiate between immune cell types, as well as to differentiate between
235:
5330:
4666:
4315:
4093:
4068:
3767:
3389:
3315:
2789:
2590:
2354:"Genetic cloaking of healthy cells opens door to universal blood cancer therapy"
2075:
Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (June 1994).
2052:
2035:
1702:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1684:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1568:. CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated
1375:
2304:
Proceedings of the
National Academy of Sciences of the United States of America
1721:
Proceedings of the
National Academy of Sciences of the United States of America
848:
negative regulation of cell adhesion involved in substrate-bound cell migration
552:
4596:
4320:
4001:
3742:
3618:
3251:
3246:
3241:
3096:
2880:
2553:
2515:
1601:
1561:
1484:
1449:
1359:
368:
265:
215:
1970:
1953:
4435:
4430:
4425:
4415:
4410:
4405:
4400:
2379:"JAX NOTES: Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change"
2315:
1741:
1642:
ENSG00000262418 GRCh38: Ensembl release 89: ENSG00000081237, ENSG00000262418
1465:
952:
612:
490:
435:
422:
334:
321:
223:
2598:
2561:
2523:
2494:
2438:
2333:
2284:
2233:
2175:
2158:
2061:
2020:
2011:
1994:
1899:
1815:
2184:
2143:
2102:
1979:
1850:
1760:
1302:
1297:
4798:
4741:
4641:
4455:
4440:
3643:
3638:
3546:
3236:
1461:
1442:
1386:
The protein product of this gene, best known as CD45, is a member of the
1286:
1101:
1082:
4691:
4686:
4681:
4581:
4395:
4385:
4212:
4191:
4186:
4154:
3959:
3879:
3874:
3869:
3864:
3859:
3777:
3470:
3310:
3305:
3300:
3295:
3290:
2761:
2648:
2638:
1616:
1596:
1391:
1336:
1068:
1019:
156:
152:
148:
144:
140:
5497:
5492:
5487:
5433:
5423:
5297:
5277:
5272:
5262:
5257:
5252:
5232:
5196:
5191:
5175:
5170:
5165:
5118:
5113:
5035:
5030:
5025:
5015:
5010:
5005:
5000:
4995:
4934:
4899:
4631:
4591:
4576:
4560:
4555:
4535:
4530:
4465:
4273:
4243:
4207:
4198:
4011:
3979:
3843:
3838:
3808:
3787:
3747:
3707:
3573:
3551:
3510:
3434:
3429:
3424:
3419:
3414:
3409:
3278:
3273:
3268:
3216:
3201:
3071:
3061:
3024:
3019:
2937:
2932:
1569:
1549:
1367:
1363:
1322:
1270:
974:
2452:
17:
1778:"Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C"
5482:
5408:
5393:
5378:
5373:
5350:
5307:
5222:
5201:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4929:
4924:
4919:
4914:
4909:
4904:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4844:
4839:
4756:
4731:
4651:
4646:
4636:
4626:
4611:
4606:
4601:
4586:
4540:
4525:
4490:
4475:
4470:
4460:
4380:
4375:
4370:
4349:
4345:
4335:
4248:
4149:
4144:
4103:
4053:
4048:
4043:
4038:
4023:
4016:
3996:
3984:
3927:
3922:
3917:
3907:
3902:
3895:
3833:
3823:
3818:
3813:
3803:
3782:
3772:
3737:
3732:
3727:
3722:
3717:
3672:
3667:
3633:
3598:
3593:
3588:
3578:
3566:
3561:
3541:
3536:
3531:
3526:
3480:
3372:
3367:
3186:
3170:
3163:
3158:
3153:
3148:
3143:
3138:
3091:
3086:
2979:
2905:
2900:
2890:
1548:
UL11 protein. This interaction results in functional paralysis of
1537:
1519:
1477:
893:
positive regulation of antigen receptor-mediated signaling pathway
2705:: Crystal structure of the tandem phosphatase domain of RPTP CD45
937:
933:
5532:
5522:
5517:
5464:
5340:
5149:
5144:
5139:
4751:
4746:
4736:
4726:
4721:
4716:
4671:
4661:
4621:
4550:
4520:
4515:
4510:
4505:
4500:
4495:
4450:
4420:
4325:
4293:
4288:
4268:
4258:
4253:
4238:
4233:
4134:
4129:
4098:
4078:
4073:
4063:
4058:
3937:
3890:
3850:
3505:
3500:
3495:
3490:
3475:
3466:
3461:
3456:
3441:
3399:
3394:
3384:
3379:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3258:
3231:
3226:
3221:
3196:
3191:
3128:
3123:
3118:
3108:
3103:
3056:
3051:
3046:
3036:
3031:
3014:
3009:
3004:
2994:
2989:
2974:
2969:
2964:
2954:
2949:
2944:
2927:
2922:
2917:
2868:
2836:
2831:
2826:
2809:
2804:
2799:
2794:
1917:(2nd ed.). Greenwich Medical Media, Ltd. pp. 121–124.
1609:
1545:
1329:
203:
4771:
2734:
2658:
2481:
Tchilian EZ, Beverley PC (2002). "CD45 in memory and disease".
1487:
region, which extends linearly out from the cell and bears the
1362:. It plays a key role in the activation and differentiation of
657:
4263:
2875:
2863:
2858:
2853:
2843:
2816:
2784:
2654:
1572:
signal intensity involved in proliferation of leukemic cells.
1531:
1525:
29:
2633:
Overview of all the structural information available in the
706:
transmembrane receptor protein tyrosine phosphatase activity
1993:
Baldwin TA, Gogela-Spehar M, Ostergaard HL (October 2000).
1452:
against the different isoforms of CD45 are used in routine
1409:
that is present in various isoforms on all differentiated
833:
negative regulation of cytokine-mediated signaling pathway
1829:
Thomas ML (1989). "The leukocyte common antigen family".
2157:
Ng DH, Watts JD, Aebersold R, Johnson P (January 1996).
838:
positive regulation of hematopoietic stem cell migration
459:
1421:). CD45 has been shown to be an essential regulator of
50:
2647:(Receptor-type tyrosine-protein phosphatase C) at the
624:
5508:
5473:
5455:
5359:
5321:
5215:
5184:
5158:
5132:
5063:
5048:
4948:
4830:
4823:
4814:
4569:
4363:
4112:
3796:
3519:
3179:
2777:
1223:
1186:
1152:
1119:
853:
negative regulation of T cell mediated cytotoxicity
45:
may be too technical for most readers to understand
1658:
1656:
1654:
1637:
1635:
1633:
1615:In 2016 a new knock-in mouse was generated on the
1544:CD45 has been recently shown to interact with the
2483:Archivum Immunologiae Et Therapiae Experimentalis
2116:Koretzky GA, Kohmetscher M, Ross S (April 1993).
1939:"Mini-review: CD45 characterization and Isoforms"
406:
305:
1441:, and so functions as a negative regulator of
808:release of sequestered calcium ion into cytosol
2403:Mercier FE, Sykes DB, Scadden DT (June 2016).
1789:
1787:
1663:GRCm38: Ensembl release 89: ENSMUSG00000026395
1315:Protein tyrosine phosphatase, receptor type, C
913:positive regulation of protein kinase activity
903:positive regulation of stem cell proliferation
813:negative regulation of protein kinase activity
4783:
2746:
2670:
888:hematopoietic progenitor cell differentiation
8:
883:positive regulation of T cell proliferation
873:positive regulation of B cell proliferation
5060:
4827:
4820:
4790:
4776:
4768:
2753:
2739:
2731:
2677:
2663:
2655:
2034:Baldwin TA, Ostergaard HL (October 2001).
948:
673:
447:
346:
243:
129:
2770:list of human clusters of differentiation
2428:
2323:
2274:
2264:
2223:
2174:
2133:
2092:
2051:
2010:
1969:
1889:
1750:
1740:
73:Learn how and when to remove this message
57:, without removing the technical details.
2381:. The Jackson Laboratory. Archived from
1808:10.1146/annurev.immunol.21.120601.140946
1772:
1770:
2692:
1629:
1608:. An alternative system is the use of
858:cell surface receptor signaling pathway
27:Mammalian protein found in Homo sapiens
84:
2347:
2345:
2343:
1952:Arendt CW, Ostergaard HL (May 1997).
1913:Leong AS, Cooper K, Leong FJ (2003).
757:integral component of plasma membrane
721:protein tyrosine phosphatase activity
411:
372:
367:
310:
269:
264:
55:make it understandable to non-experts
7:
2612:Immunology course for undergraduates
1866:"CD45: all is not yet crystal clear"
2163:The Journal of Biological Chemistry
2122:The Journal of Biological Chemistry
2081:The Journal of Biological Chemistry
1999:The Journal of Biological Chemistry
1958:The Journal of Biological Chemistry
1843:10.1146/annurev.iy.07.040189.002011
1325:that, in humans, is encoded by the
918:peptidyl-tyrosine dephosphorylation
691:phosphoprotein phosphatase activity
2198:Wu L, Fu J, Shen SH (April 2002).
1220:
1183:
1149:
1116:
1092:
1073:
1047:
1024:
998:
979:
629:
547:
485:
464:
25:
2453:"002014 - B6.SJL-Ptprc Pepc/BoyJ"
898:T cell receptor signaling pathway
798:B cell receptor signaling pathway
2710:
2695:
1882:10.1111/j.1365-2567.2005.02265.x
777:external side of plasma membrane
647:
640:
633:
395:
388:
382:
359:
294:
287:
281:
256:
93:
34:
2216:10.1128/mcb.22.8.2673-2686.2002
1343:), which was originally called
2204:Molecular and Cellular Biology
737:integral component of membrane
658:More reference expression data
613:More reference expression data
1:
4803:protein tyrosine phosphatases
2135:10.1016/S0021-9258(18)52965-3
2094:10.1016/S0021-9258(17)32545-0
1915:Manual of Diagnostic Cytology
380:
279:
2421:10.1016/j.stemcr.2016.04.010
2266:10.1371/journal.ppat.1002432
1941:. Bio-Rad Laboratories, Inc.
1433:), or by activating various
1407:type I transmembrane protein
1388:protein tyrosine phosphatase
5559:Clusters of differentiation
5554:Genes on human chromosome 1
2766:clusters of differentiation
2591:10.1016/j.imlet.2004.05.011
2053:10.4049/jimmunol.167.7.3829
1831:Annual Review of Immunology
1796:Annual Review of Immunology
1595:There are two identifiable
1585:Blood stem cell transplants
803:cell cycle phase transition
5575:
1864:Holmes N (February 2006).
1398:, and thus belongs to the
1341:cluster of differentiation
1332:. PTPRC is also known as
782:secretory granule membrane
2690:
2554:10.1007/s00251-004-0668-z
2516:10.3109/10428190309178767
1698:"Mouse PubMed Reference:"
1680:"Human PubMed Reference:"
1301:
1296:
1292:
1285:
1269:
1256:Chr 1: 198.64 – 198.76 Mb
1250:
1227:
1190:
1179:
1156:
1123:
1112:
1099:
1095:
1080:
1076:
1067:
1054:
1050:
1031:
1027:
1018:
1005:
1001:
986:
982:
973:
958:
951:
947:
931:
878:defense response to virus
828:protein dephosphorylation
676:
672:
655:
632:
623:
610:
559:
550:
513:epithelium of nasopharynx
497:
488:
458:
450:
446:
429:
416:
379:
358:
349:
345:
328:
315:
278:
255:
246:
242:
197:
194:
184:
177:
172:
137:
132:
115:
110:
105:
101:
92:
87:
1971:10.1074/jbc.272.20.13117
1591:Use as a congenic marker
1511:PTPRC has been shown to
1345:leukocyte common antigen
1263:Chr 1: 137.99 – 138.1 Mb
923:neutrophil degranulation
843:regulation of cell cycle
2504:Leukemia & Lymphoma
2316:10.1073/pnas.1312420110
1742:10.1073/pnas.87.18.7000
1581:antibody-drug conjugate
1427:B-cell antigen receptor
818:bone marrow development
5322:Phosphatase and tensin
4949:Non receptor type PTPs
2176:10.1074/jbc.271.3.1295
2012:10.1074/jbc.M003088200
1566:acute myeloid leukemia
868:T cell differentiation
711:protein kinase binding
599:mesenteric lymph nodes
2377:Mobraaten LE (1994).
2352:Mole B (2024-07-15).
2040:Journal of Immunology
1577:genetically modifying
1458:histological sections
823:stem cell development
772:extracellular exosome
579:stroma of bone marrow
1454:immunohistochemistry
1445:receptor signaling.
863:B cell proliferation
696:phosphatase activity
413:1 E4|1 60.73 cM
374:Chromosome 1 (mouse)
272:Chromosome 1 (human)
133:List of PDB id codes
106:Available structures
2310:(50): E4884–E4893.
2087:(25): 17238–17244.
2005:(41): 32071–32076.
1964:(20): 13117–13125.
1733:1990PNAS...87.7000K
1556:Clinical importance
1356:hematopoietic cells
583:submandibular gland
4832:Receptor type PTPs
2614:. Davidson College
2606:Jameson R (2006).
2579:Immunology Letters
1435:Src family kinases
1057:ENSMUSG00000026395
791:Biological process
730:Cellular component
716:hydrolase activity
684:Molecular function
575:tibiofemoral joint
5541:
5540:
5451:
5450:
5447:
5446:
5065:MAPK phosphatases
5044:
5043:
4765:
4764:
2728:
2727:
2409:Stem Cell Reports
2128:(12): 8958–8964.
1727:(18): 7000–7004.
1400:receptor type PTP
1396:catalytic domains
1312:
1311:
1308:
1307:
1281:
1280:
1246:
1245:
1217:
1216:
1175:
1174:
1146:
1145:
1108:
1107:
1089:
1088:
1063:
1062:
1044:
1043:
1014:
1013:
995:
994:
943:
942:
908:dephosphorylation
668:
667:
664:
663:
619:
618:
606:
605:
544:
543:
529:bone marrow cells
442:
441:
341:
340:
236:PTPRC - orthologs
168:
167:
164:
163:
116:Ortholog search:
83:
82:
75:
16:(Redirected from
5566:
5324:homologs (PTENs)
5061:
4828:
4821:
4792:
4785:
4778:
4769:
2755:
2748:
2741:
2732:
2714:
2699:
2679:
2672:
2665:
2656:
2622:
2620:
2619:
2602:
2573:
2535:
2510:(9): 1477–1481.
2498:
2467:
2466:
2464:
2463:
2449:
2443:
2442:
2432:
2400:
2394:
2393:
2391:
2390:
2374:
2368:
2367:
2365:
2364:
2349:
2338:
2337:
2327:
2295:
2289:
2288:
2278:
2268:
2259:(12): e1002432.
2244:
2238:
2237:
2227:
2210:(8): 2673–2686.
2195:
2189:
2188:
2178:
2169:(3): 1295–1300.
2154:
2148:
2147:
2137:
2113:
2107:
2106:
2096:
2072:
2066:
2065:
2055:
2046:(7): 3829–3835.
2031:
2025:
2024:
2014:
1990:
1984:
1983:
1973:
1949:
1943:
1942:
1935:
1929:
1928:
1910:
1904:
1903:
1893:
1861:
1855:
1854:
1826:
1820:
1819:
1791:
1782:
1781:
1774:
1765:
1764:
1754:
1744:
1712:
1706:
1705:
1694:
1688:
1687:
1676:
1670:
1660:
1649:
1639:
1294:
1293:
1265:
1258:
1241:
1221:
1212:
1184:
1180:RefSeq (protein)
1170:
1150:
1141:
1117:
1093:
1074:
1048:
1025:
999:
980:
949:
674:
660:
651:
644:
637:
630:
615:
555:
553:Top expressed in
548:
493:
491:Top expressed in
486:
465:
448:
438:
425:
414:
399:
392:
386:
375:
363:
347:
337:
324:
313:
298:
291:
285:
274:
260:
244:
238:
189:
182:
159:
130:
124:
103:
102:
97:
85:
78:
71:
67:
64:
58:
38:
37:
30:
21:
5574:
5573:
5569:
5568:
5567:
5565:
5564:
5563:
5544:
5543:
5542:
5537:
5504:
5469:
5443:
5355:
5323:
5317:
5211:
5180:
5154:
5128:
5056:
5053:
5050:
5040:
4944:
4810:
4796:
4766:
4761:
4565:
4359:
4108:
3792:
3515:
3175:
2773:
2759:
2729:
2724:
2721:
2715:
2706:
2700:
2686:
2683:
2630:
2625:
2617:
2615:
2605:
2576:
2538:
2501:
2480:
2476:
2471:
2470:
2461:
2459:
2451:
2450:
2446:
2402:
2401:
2397:
2388:
2386:
2376:
2375:
2371:
2362:
2360:
2351:
2350:
2341:
2297:
2296:
2292:
2246:
2245:
2241:
2197:
2196:
2192:
2156:
2155:
2151:
2115:
2114:
2110:
2074:
2073:
2069:
2033:
2032:
2028:
1992:
1991:
1987:
1951:
1950:
1946:
1937:
1936:
1932:
1925:
1912:
1911:
1907:
1863:
1862:
1858:
1828:
1827:
1823:
1793:
1792:
1785:
1776:
1775:
1768:
1714:
1713:
1709:
1696:
1695:
1691:
1678:
1677:
1673:
1661:
1652:
1640:
1631:
1626:
1593:
1558:
1509:
1489:O-linked glycan
1474:
1384:
1372:immune response
1358:, particularly
1339:(CD stands for
1303:View/Edit Mouse
1298:View/Edit Human
1261:
1254:
1251:Location (UCSC)
1237:
1233:
1229:
1208:
1204:
1200:
1196:
1192:
1166:
1162:
1158:
1137:
1133:
1129:
1125:
1038:ENSG00000262418
1036:
1034:ENSG00000081237
927:
786:
752:plasma membrane
725:
701:protein binding
656:
646:
645:
639:
638:
611:
602:
597:
593:
589:
585:
581:
577:
573:
569:
565:
551:
540:
535:
531:
527:
523:
519:
515:
511:
507:
503:
489:
433:
420:
412:
402:
401:
400:
393:
373:
350:Gene location (
332:
319:
311:
301:
300:
299:
292:
270:
247:Gene location (
198:
185:
178:
139:
117:
79:
68:
62:
59:
51:help improve it
48:
39:
35:
28:
23:
22:
15:
12:
11:
5:
5572:
5570:
5562:
5561:
5556:
5546:
5545:
5539:
5538:
5536:
5535:
5530:
5525:
5520:
5514:
5512:
5506:
5505:
5503:
5502:
5501:
5500:
5495:
5490:
5479:
5477:
5471:
5470:
5468:
5467:
5461:
5459:
5453:
5452:
5449:
5448:
5445:
5444:
5442:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5365:
5363:
5357:
5356:
5354:
5353:
5348:
5343:
5338:
5333:
5327:
5325:
5319:
5318:
5316:
5315:
5310:
5305:
5300:
5295:
5290:
5285:
5280:
5275:
5270:
5265:
5260:
5255:
5250:
5245:
5240:
5235:
5230:
5225:
5219:
5217:
5213:
5212:
5210:
5209:
5204:
5199:
5194:
5188:
5186:
5182:
5181:
5179:
5178:
5173:
5168:
5162:
5160:
5156:
5155:
5153:
5152:
5147:
5142:
5136:
5134:
5130:
5129:
5127:
5126:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5070:
5068:
5058:
5046:
5045:
5042:
5041:
5039:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4952:
4950:
4946:
4945:
4943:
4942:
4937:
4932:
4927:
4922:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4852:
4847:
4842:
4836:
4834:
4825:
4824:Classical PTPs
4818:
4812:
4811:
4797:
4795:
4794:
4787:
4780:
4772:
4763:
4762:
4760:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4704:
4699:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4573:
4571:
4567:
4566:
4564:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4367:
4365:
4361:
4360:
4358:
4357:
4352:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4297:
4296:
4291:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4210:
4201:
4196:
4195:
4194:
4189:
4179:
4174:
4173:
4172:
4167:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4116:
4114:
4110:
4109:
4107:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4020:
4019:
4014:
4004:
3999:
3994:
3989:
3988:
3987:
3982:
3977:
3967:
3962:
3957:
3952:
3947:
3946:
3945:
3940:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3899:
3898:
3893:
3883:
3877:
3872:
3867:
3862:
3853:
3848:
3847:
3846:
3841:
3836:
3826:
3821:
3816:
3811:
3806:
3800:
3798:
3794:
3793:
3791:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3664:
3663:
3658:
3648:
3647:
3646:
3641:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3570:
3569:
3564:
3554:
3549:
3544:
3539:
3534:
3529:
3523:
3521:
3517:
3516:
3514:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3464:
3459:
3454:
3449:
3444:
3439:
3438:
3437:
3432:
3427:
3422:
3417:
3412:
3402:
3397:
3392:
3387:
3382:
3377:
3376:
3375:
3370:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3319:
3318:
3313:
3308:
3303:
3298:
3293:
3283:
3282:
3281:
3276:
3271:
3261:
3256:
3255:
3254:
3249:
3244:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3183:
3181:
3177:
3176:
3174:
3173:
3168:
3167:
3166:
3161:
3156:
3151:
3146:
3141:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3100:
3099:
3094:
3089:
3084:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3028:
3027:
3022:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2941:
2940:
2935:
2925:
2920:
2915:
2910:
2909:
2908:
2903:
2898:
2893:
2883:
2878:
2873:
2872:
2871:
2861:
2856:
2851:
2846:
2841:
2840:
2839:
2834:
2829:
2819:
2814:
2813:
2812:
2807:
2802:
2797:
2792:
2781:
2779:
2775:
2774:
2760:
2758:
2757:
2750:
2743:
2735:
2726:
2725:
2723:
2722:
2716:
2709:
2707:
2701:
2694:
2691:
2688:
2687:
2684:
2682:
2681:
2674:
2667:
2659:
2653:
2652:
2629:
2628:External links
2626:
2624:
2623:
2603:
2585:(3): 167–174.
2574:
2548:(2): 107–110.
2542:Immunogenetics
2536:
2499:
2477:
2475:
2472:
2469:
2468:
2444:
2415:(6): 985–992.
2395:
2369:
2339:
2290:
2253:PLoS Pathogens
2239:
2190:
2149:
2108:
2067:
2026:
1985:
1944:
1930:
1923:
1905:
1876:(2): 145–155.
1856:
1821:
1783:
1766:
1707:
1689:
1671:
1650:
1628:
1627:
1625:
1622:
1592:
1589:
1557:
1554:
1542:
1541:
1535:
1529:
1523:
1508:
1505:
1473:
1470:
1431:co-stimulation
1413:cells (except
1383:
1380:
1317:also known as
1310:
1309:
1306:
1305:
1300:
1290:
1289:
1283:
1282:
1279:
1278:
1276:
1274:
1267:
1266:
1259:
1252:
1248:
1247:
1244:
1243:
1225:
1224:
1218:
1215:
1214:
1188:
1187:
1181:
1177:
1176:
1173:
1172:
1154:
1153:
1147:
1144:
1143:
1121:
1120:
1114:
1110:
1109:
1106:
1105:
1097:
1096:
1090:
1087:
1086:
1078:
1077:
1071:
1065:
1064:
1061:
1060:
1052:
1051:
1045:
1042:
1041:
1029:
1028:
1022:
1016:
1015:
1012:
1011:
1003:
1002:
996:
993:
992:
984:
983:
977:
971:
970:
965:
960:
956:
955:
945:
944:
941:
940:
929:
928:
926:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
794:
792:
788:
787:
785:
784:
779:
774:
769:
764:
759:
754:
749:
747:focal adhesion
744:
739:
733:
731:
727:
726:
724:
723:
718:
713:
708:
703:
698:
693:
687:
685:
681:
680:
670:
669:
666:
665:
662:
661:
653:
652:
627:
621:
620:
617:
616:
608:
607:
604:
603:
601:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
560:
557:
556:
545:
542:
541:
539:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
495:
494:
482:
481:
473:
462:
456:
455:
452:RNA expression
444:
443:
440:
439:
431:
427:
426:
418:
415:
410:
404:
403:
394:
387:
381:
377:
376:
371:
365:
364:
356:
355:
343:
342:
339:
338:
330:
326:
325:
317:
314:
309:
303:
302:
293:
286:
280:
276:
275:
268:
262:
261:
253:
252:
240:
239:
196:
192:
191:
183:
175:
174:
170:
169:
166:
165:
162:
161:
135:
134:
126:
125:
114:
108:
107:
99:
98:
90:
89:
81:
80:
42:
40:
33:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5571:
5560:
5557:
5555:
5552:
5551:
5549:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5515:
5513:
5511:
5507:
5499:
5496:
5494:
5491:
5489:
5486:
5485:
5484:
5481:
5480:
5478:
5476:
5472:
5466:
5463:
5462:
5460:
5458:
5454:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5366:
5364:
5362:
5361:Myotubularins
5358:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5328:
5326:
5320:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5264:
5261:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5239:
5236:
5234:
5231:
5229:
5226:
5224:
5221:
5220:
5218:
5216:Atypical DSPs
5214:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5189:
5187:
5183:
5177:
5174:
5172:
5169:
5167:
5164:
5163:
5161:
5157:
5151:
5148:
5146:
5143:
5141:
5138:
5137:
5135:
5131:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5071:
5069:
5066:
5062:
5059:
5055:
5052:dual specific
5047:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4953:
4951:
4947:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4846:
4843:
4841:
4838:
4837:
4835:
4833:
4829:
4826:
4822:
4819:
4817:
4813:
4808:
4804:
4800:
4793:
4788:
4786:
4781:
4779:
4774:
4773:
4770:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4574:
4572:
4568:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4368:
4366:
4362:
4356:
4353:
4351:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4295:
4292:
4290:
4287:
4286:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4214:
4211:
4209:
4205:
4202:
4200:
4197:
4193:
4190:
4188:
4185:
4184:
4183:
4180:
4178:
4175:
4171:
4168:
4166:
4163:
4162:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4117:
4115:
4111:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4018:
4015:
4013:
4010:
4009:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3986:
3983:
3981:
3978:
3976:
3973:
3972:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
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3939:
3936:
3935:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3897:
3894:
3892:
3889:
3888:
3887:
3884:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3857:
3854:
3852:
3849:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3801:
3799:
3795:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3662:
3659:
3657:
3654:
3653:
3652:
3649:
3645:
3642:
3640:
3637:
3636:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3568:
3565:
3563:
3560:
3559:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
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3522:
3518:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3407:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3374:
3371:
3369:
3366:
3365:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3288:
3287:
3284:
3280:
3277:
3275:
3272:
3270:
3267:
3266:
3265:
3262:
3260:
3257:
3253:
3250:
3248:
3245:
3243:
3240:
3239:
3238:
3235:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3184:
3182:
3178:
3172:
3169:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3136:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3079:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3026:
3023:
3021:
3018:
3017:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2939:
2936:
2934:
2931:
2930:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2888:
2887:
2884:
2882:
2879:
2877:
2874:
2870:
2867:
2866:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2838:
2835:
2833:
2830:
2828:
2825:
2824:
2823:
2820:
2818:
2815:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2787:
2786:
2783:
2782:
2780:
2776:
2771:
2767:
2763:
2756:
2751:
2749:
2744:
2742:
2737:
2736:
2733:
2719:
2713:
2708:
2704:
2698:
2693:
2689:
2680:
2675:
2673:
2668:
2666:
2661:
2660:
2657:
2650:
2646:
2645:
2640:
2636:
2632:
2631:
2627:
2613:
2609:
2604:
2600:
2596:
2592:
2588:
2584:
2580:
2575:
2571:
2567:
2563:
2559:
2555:
2551:
2547:
2543:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2500:
2496:
2492:
2488:
2484:
2479:
2478:
2473:
2458:
2454:
2448:
2445:
2440:
2436:
2431:
2426:
2422:
2418:
2414:
2410:
2406:
2399:
2396:
2385:on 2015-01-08
2384:
2380:
2373:
2370:
2359:
2355:
2348:
2346:
2344:
2340:
2335:
2331:
2326:
2321:
2317:
2313:
2309:
2305:
2301:
2294:
2291:
2286:
2282:
2277:
2272:
2267:
2262:
2258:
2254:
2250:
2243:
2240:
2235:
2231:
2226:
2221:
2217:
2213:
2209:
2205:
2201:
2194:
2191:
2186:
2182:
2177:
2172:
2168:
2164:
2160:
2153:
2150:
2145:
2141:
2136:
2131:
2127:
2123:
2119:
2112:
2109:
2104:
2100:
2095:
2090:
2086:
2082:
2078:
2071:
2068:
2063:
2059:
2054:
2049:
2045:
2041:
2037:
2030:
2027:
2022:
2018:
2013:
2008:
2004:
2000:
1996:
1989:
1986:
1981:
1977:
1972:
1967:
1963:
1959:
1955:
1948:
1945:
1940:
1934:
1931:
1926:
1924:1-84110-100-1
1920:
1916:
1909:
1906:
1901:
1897:
1892:
1887:
1883:
1879:
1875:
1871:
1867:
1860:
1857:
1852:
1848:
1844:
1840:
1836:
1832:
1825:
1822:
1817:
1813:
1809:
1805:
1801:
1797:
1790:
1788:
1784:
1779:
1773:
1771:
1767:
1762:
1758:
1753:
1748:
1743:
1738:
1734:
1730:
1726:
1722:
1718:
1711:
1708:
1703:
1699:
1693:
1690:
1685:
1681:
1675:
1672:
1668:
1664:
1659:
1657:
1655:
1651:
1647:
1643:
1638:
1636:
1634:
1630:
1623:
1621:
1618:
1613:
1611:
1607:
1603:
1598:
1590:
1588:
1586:
1582:
1578:
1573:
1571:
1567:
1563:
1555:
1553:
1551:
1547:
1539:
1536:
1533:
1530:
1527:
1524:
1521:
1518:
1517:
1516:
1514:
1506:
1504:
1500:
1496:
1492:
1490:
1486:
1481:
1479:
1471:
1469:
1467:
1463:
1459:
1455:
1451:
1446:
1444:
1440:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1411:hematopoietic
1408:
1403:
1401:
1397:
1393:
1389:
1381:
1379:
1377:
1373:
1369:
1365:
1361:
1357:
1352:
1350:
1346:
1342:
1338:
1335:
1331:
1328:
1324:
1320:
1316:
1304:
1299:
1295:
1291:
1288:
1284:
1277:
1275:
1272:
1268:
1264:
1260:
1257:
1253:
1249:
1242:
1240:
1236:
1232:
1226:
1222:
1219:
1213:
1211:
1207:
1203:
1199:
1195:
1189:
1185:
1182:
1178:
1171:
1169:
1165:
1161:
1155:
1151:
1148:
1142:
1140:
1136:
1132:
1128:
1122:
1118:
1115:
1113:RefSeq (mRNA)
1111:
1104:
1103:
1098:
1094:
1091:
1085:
1084:
1079:
1075:
1072:
1070:
1066:
1059:
1058:
1053:
1049:
1046:
1040:
1039:
1035:
1030:
1026:
1023:
1021:
1017:
1010:
1009:
1004:
1000:
997:
991:
990:
985:
981:
978:
976:
972:
969:
966:
964:
961:
957:
954:
950:
946:
939:
935:
930:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
795:
793:
790:
789:
783:
780:
778:
775:
773:
770:
768:
767:membrane raft
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
734:
732:
729:
728:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
688:
686:
683:
682:
679:
678:Gene ontology
675:
671:
659:
654:
650:
643:
636:
631:
628:
626:
622:
614:
609:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
561:
558:
554:
549:
546:
536:
532:
528:
524:
520:
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120:
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109:
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100:
96:
91:
86:
77:
74:
66:
56:
52:
46:
43:This article
41:
32:
31:
19:
5054:phosphatases
4849:
4283:
4203:
4181:
4159:
4006:
3969:
3932:
3885:
3855:
3828:
3650:
3556:
3404:
3133:
3113:
2885:
2717:
2702:
2642:
2616:. Retrieved
2611:
2582:
2578:
2545:
2541:
2507:
2503:
2489:(2): 85–93.
2486:
2482:
2474:Bibliography
2460:. Retrieved
2456:
2447:
2412:
2408:
2398:
2387:. Retrieved
2383:the original
2372:
2361:. Retrieved
2358:Ars Technica
2357:
2307:
2303:
2293:
2256:
2252:
2242:
2207:
2203:
2193:
2166:
2162:
2152:
2125:
2121:
2111:
2084:
2080:
2070:
2043:
2039:
2029:
2002:
1998:
1988:
1961:
1957:
1947:
1933:
1914:
1908:
1873:
1869:
1859:
1834:
1830:
1824:
1799:
1795:
1724:
1720:
1710:
1701:
1692:
1683:
1674:
1614:
1594:
1574:
1559:
1543:
1510:
1507:Interactions
1501:
1497:
1493:
1482:
1475:
1447:
1419:plasma cells
1415:erythrocytes
1404:
1385:
1353:
1348:
1344:
1333:
1326:
1318:
1314:
1313:
1235:NP_001255215
1231:NP_001104786
1228:
1194:NP_001254727
1191:
1164:NM_001268286
1160:NM_001111316
1157:
1127:NM_001267798
1124:
1100:
1081:
1055:
1032:
1006:
987:
967:
962:
762:cell surface
475:
468:
434:138,103,446
421:137,990,599
333:198,757,476
320:198,638,457
312:1q31.3-q32.1
195:External IDs
138:
69:
60:
44:
5049:VH1-like or
2685:PDB gallery
2457:www.jax.org
1802:: 107–137.
1562:lipid rafts
1439:JAK kinases
1376:homeostasis
1360:lymphocytes
1210:NP_002829.3
1206:NP_563578.2
595:Paneth cell
563:granulocyte
525:bone marrow
517:granulocyte
173:Identifiers
5548:Categories
5133:Slingshots
2768:(see also
2618:2011-10-24
2462:2020-10-11
2389:2015-01-08
2363:2024-07-15
1870:Immunology
1837:: 339–69.
1669:, May 2017
1648:, May 2017
1624:References
1602:leukocytes
1485:N-terminal
1466:carcinomas
1450:Antibodies
1405:CD45 is a
591:right lung
521:lymph node
479:(ortholog)
216:HomoloGene
5475:Class III
4809:3.1.3.48)
1491:chains.
1462:lymphomas
1239:NP_035340
1202:NP_563578
1198:NP_002829
1168:NM_011210
1139:NM_080922
1135:NM_080921
1131:NM_002838
953:Orthologs
224:GeneCards
63:July 2024
5510:Class IV
5457:Class II
4799:Esterase
2762:Proteins
2599:15275963
2570:10179258
2562:15057492
2532:19867177
2524:14565647
2495:12022705
2439:27185283
2334:24218549
2285:22174689
2234:11909961
2062:11564800
2021:10921916
1900:16423050
1816:12414720
1665:–
1644:–
1606:chimeras
1513:interact
1472:Isoforms
1443:cytokine
1402:family.
1382:Function
1287:Wikidata
932:Sources:
742:membrane
505:appendix
501:monocyte
5243:DUSP13B
5238:DUSP13A
5207:PTP9Q22
5124:MK-STYX
4816:Class I
4570:301–350
4364:251–300
4316:CD240CE
4113:201–250
3797:151–200
3520:101–150
2649:PDBe-KB
2639:UniProt
2430:4911492
2325:3864294
2276:3234252
2185:8576115
2144:8473339
2103:7516335
1980:9148925
1891:1782222
1851:2523715
1761:2169617
1729:Bibcode
1667:Ensembl
1646:Ensembl
1617:C57BL/6
1597:alleles
1550:T cells
1392:mitotic
1368:B cells
1364:T cells
1337:antigen
1069:UniProt
1020:Ensembl
959:Species
938:QuickGO
454:pattern
180:Aliases
49:Please
5498:CDC25C
5493:CDC25B
5488:CDC25A
5439:MTMR15
5434:MTMR14
5429:MTMR13
5424:MTMR12
5419:MTMR11
5414:MTMR10
5298:DUSP27
5293:DUSP26
5288:DUSP25
5283:DUSP24
5278:DUSP23
5273:DUSP22
5268:DUSP21
5263:DUSP19
5258:DUSP18
5253:DUSP15
5248:DUSP14
5233:DUSP12
5228:DUSP11
5197:CDC14B
5192:CDC14A
5185:CDC14s
5176:PTP4A3
5171:PTP4A2
5166:PTP4A1
5119:DUSP16
5114:DUSP10
5067:(MKPs)
5057:(DSPs)
5036:PTPN23
5031:PTPN22
5026:PTPN21
5021:PTPN20
5016:PTPN18
5011:PTPN14
5006:PTPN13
5001:PTPN12
4996:PTPN11
4940:PTPRZ2
4935:PTPRZ1
4900:PTPRN2
4577:CD300A
4536:CDw293
4321:CD240D
4182:CD213a
4160:CDw210
4125:CD202b
4099:CDw199
4094:CDw198
3748:CD140b
3180:51–100
2644:P08575
2608:"CD45"
2597:
2568:
2560:
2530:
2522:
2493:
2437:
2427:
2332:
2322:
2283:
2273:
2232:
2225:133720
2222:
2183:
2142:
2101:
2060:
2019:
1978:
1921:
1898:
1888:
1849:
1814:
1759:
1749:
1570:GM-CSF
1515:with:
1323:enzyme
1321:is an
1273:search
1271:PubMed
1102:P06800
1083:P08575
975:Entrez
625:BioGPS
571:thymus
567:spleen
537:spleen
533:thymus
204:151460
5483:Cdc25
5409:MTMR9
5404:MTMR8
5399:MTMR7
5394:MTMR6
5389:MTMR5
5384:MTMR4
5379:MTMR3
5374:MTMR2
5351:TENC1
5308:RNGTT
5303:EMP2A
5223:DUSP3
5202:CDKN3
5109:DUSP9
5104:DUSP8
5099:DUSP7
5094:DUSP6
5089:DUSP5
5084:DUSP4
5079:DUSP2
5074:DUSP1
4991:PTPN9
4986:PTPN7
4981:PTPN6
4976:PTPN5
4971:PTPN4
4966:PTPN3
4961:PTPN2
4956:PTPN1
4930:PTPRU
4925:PTPRT
4920:PTPRS
4915:PTPRR
4910:PTPRQ
4905:PTPRO
4895:PTPRN
4890:PTPRM
4885:PTPRK
4880:PTPRJ
4875:PTPRH
4870:PTPRG
4865:PTPRF
4860:PTPRE
4855:PTPRD
4850:PTPRC
4845:PTPRB
4840:PTPRA
4757:CD350
4752:CD349
4747:CD344
4742:CD340
4737:CD339
4732:CD338
4727:CD337
4722:CD336
4717:CD335
4712:CD334
4707:CD333
4702:CD332
4697:CD331
4692:CD329
4687:CD328
4682:CD327
4677:CD326
4672:CD325
4667:CD324
4662:CD322
4657:CD321
4652:CD320
4647:CD318
4642:CD317
4637:CD316
4632:CD315
4627:CD314
4622:CD312
4617:CD309
4612:CD307
4607:CD306
4602:CD305
4597:CD304
4592:CD303
4587:CD302
4582:CD301
4561:CD299
4556:CD298
4551:CD297
4546:CD295
4541:CD294
4531:CD292
4526:CD290
4521:CD289
4516:CD288
4511:CD286
4506:CD284
4501:CD283
4496:CD282
4491:CD281
4486:CD280
4481:CD279
4476:CD278
4471:CD276
4466:CD275
4461:CD274
4456:CD273
4451:CD272
4446:CD271
4441:CD269
4436:CD268
4431:CD267
4426:CD266
4421:CD265
4416:CD264
4411:CD263
4406:CD262
4401:CD261
4396:CD258
4391:CD257
4386:CD256
4381:CD254
4376:CD253
4371:CD252
4355:CD249
4350:CD248
4346:CD247
4341:CD246
4336:CD244
4331:CD243
4326:CD241
4311:CD239
4306:CD238
4301:CD236
4284:CD235
4279:CD234
4274:CD233
4269:CD230
4264:CD229
4259:CD228
4254:CD227
4249:CD226
4244:CD225
4239:CD224
4234:CD223
4229:CD222
4224:CD221
4219:CD220
4204:CD218
4199:CD217
4177:CD212
4155:CD209
4150:CD208
4145:CD207
4140:CD206
4135:CD205
4130:CD204
4120:CD201
4104:CD200
4089:CD197
4084:CD196
4079:CD195
4074:CD194
4069:CD193
4064:CD192
4059:CD191
4054:CD186
4049:CD185
4044:CD184
4039:CD183
4034:CD182
4029:CD181
4024:CD180
4007:CD179
4002:CD178
3997:CD177
3992:CD174
3970:CD172
3965:CD171
3960:CD170
3955:CD169
3950:CD168
3933:CD167
3928:CD166
3923:CD164
3918:CD163
3913:CD162
3908:CD161
3903:CD160
3886:CD159
3856:CD158
3851:CD157
3829:CD156
3824:CD155
3819:CD154
3814:CD153
3809:CD152
3804:CD151
3788:CD150
3783:CD148
3778:CD147
3773:CD146
3768:CD144
3763:CD143
3758:CD142
3753:CD141
3743:CD138
3738:CD137
3733:CD136
3728:CD135
3723:CD134
3718:CD133
3713:CD132
3708:CD131
3703:CD130
3698:CD129
3693:CD127
3688:CD126
3683:CD125
3678:CD124
3673:CD123
3668:CD122
3651:CD121
3634:CD120
3629:CD119
3624:CD118
3619:CD117
3614:CD116
3609:CD115
3604:CD114
3599:CD113
3594:CD112
3589:CD111
3584:CD110
3579:CD109
3574:CD108
3557:CD107
3552:CD106
3547:CD105
3542:CD104
3537:CD103
3532:CD102
3527:CD101
3511:CD100
2566:S2CID
2528:S2CID
1752:54670
1538:SKAP1
1534:, and
1520:GANAB
1478:exons
1460:from
1327:PTPRC
1319:PTPRC
1008:19264
968:Mouse
963:Human
934:Amigo
587:blood
509:blood
477:Mouse
470:Human
417:Start
352:Mouse
316:Start
249:Human
228:PTPRC
212:97810
187:PTPRC
88:PTPRC
5533:EYA4
5528:EYA3
5523:EYA2
5518:EYA1
5465:ACP1
5369:MTM1
5341:TPTE
5336:TPIP
5331:PTEN
5313:STYX
5159:PRLs
5150:SSH3
5145:SSH2
5140:SSH1
3506:CD99
3501:CD98
3496:CD97
3491:CD96
3486:CD95
3481:CD94
3476:CD93
3471:CD92
3467:CD91
3462:CD90
3457:CD89
3452:CD88
3447:CD87
3442:CD86
3405:CD85
3400:CD84
3395:CD83
3390:CD82
3385:CD81
3380:CD80
3363:CD79
3358:CD78
3353:CD74
3348:CD73
3343:CD72
3338:CD71
3333:CD70
3328:CD69
3323:CD68
3286:CD66
3264:CD64
3259:CD63
3237:CD62
3232:CD61
3227:CD59
3222:CD58
3217:CD57
3212:CD56
3207:CD55
3202:CD54
3197:CD53
3192:CD52
3187:CD51
3171:CD50
3134:CD49
3129:CD48
3124:CD47
3119:CD46
3114:CD45
3109:CD44
3104:CD43
3077:CD42
3072:CD41
3067:CD40
3062:CD39
3057:CD38
3052:CD37
3047:CD36
3042:CD35
3037:CD34
3032:CD33
3015:CD32
3010:CD31
3005:CD30
3000:CD29
2995:CD28
2990:CD27
2985:CD26
2980:CD25
2975:CD24
2970:CD23
2965:CD22
2960:CD21
2955:CD20
2950:CD19
2945:CD18
2928:CD16
2923:CD15
2918:CD14
2913:CD13
2886:CD11
2881:CD10
2778:1–50
2718:1ygu
2703:1ygr
2637:for
2595:PMID
2558:PMID
2520:PMID
2491:PMID
2435:PMID
2330:PMID
2281:PMID
2230:PMID
2181:PMID
2140:PMID
2099:PMID
2058:PMID
2017:PMID
1976:PMID
1919:ISBN
1896:PMID
1847:PMID
1812:PMID
1757:PMID
1610:CD90
1546:HCMV
1464:and
1425:and
1417:and
1374:and
1334:CD45
1330:gene
989:5788
460:Bgee
408:Band
369:Chr.
307:Band
266:Chr.
220:2126
200:OMIM
157:5FN7
153:5FN6
149:5FMV
145:1YGR
141:1YGU
122:RCSB
119:PDBe
18:CD45
5346:TNS
2876:CD9
2864:CD8
2859:CD7
2854:CD6
2849:CD5
2844:CD4
2822:CD3
2817:CD2
2790:a-c
2785:CD1
2635:PDB
2587:doi
2550:doi
2512:doi
2425:PMC
2417:doi
2320:PMC
2312:doi
2308:110
2271:PMC
2261:doi
2220:PMC
2212:doi
2171:doi
2167:271
2130:doi
2126:268
2089:doi
2085:269
2048:doi
2044:167
2007:doi
2003:275
1966:doi
1962:272
1886:PMC
1878:doi
1874:117
1839:doi
1804:doi
1747:PMC
1737:doi
1532:Lck
1526:LYN
1351:).
1349:LCA
430:End
329:End
232:OMA
208:MGI
112:PDB
53:to
5550::
4807:EC
4801::
4348:-
3469:-
2810:1E
2805:1D
2800:1B
2795:1A
2764::
2641::
2610:.
2593:.
2583:94
2581:.
2564:.
2556:.
2546:56
2544:.
2526:.
2518:.
2508:44
2506:.
2487:50
2485:.
2455:.
2433:.
2423:.
2411:.
2407:.
2356:.
2342:^
2328:.
2318:.
2306:.
2302:.
2279:.
2269:.
2255:.
2251:.
2228:.
2218:.
2208:22
2206:.
2202:.
2179:.
2165:.
2161:.
2138:.
2124:.
2120:.
2097:.
2083:.
2079:.
2056:.
2042:.
2038:.
2015:.
2001:.
1997:.
1974:.
1960:.
1956:.
1894:.
1884:.
1872:.
1868:.
1845:.
1833:.
1810:.
1800:21
1798:.
1786:^
1769:^
1755:.
1745:.
1735:.
1725:87
1723:.
1719:.
1700:.
1682:.
1653:^
1632:^
1468:.
1423:T-
1378:.
1366:,
936:/
436:bp
423:bp
335:bp
322:bp
230:;
226::
222:;
218::
214:;
210::
206:;
202::
155:,
151:,
147:,
143:,
4805:(
4791:e
4784:t
4777:v
4294:b
4289:a
4215:)
4213:b
4208:a
4206:(
4192:2
4187:1
4170:b
4165:a
4017:b
4012:a
3985:g
3980:b
3975:a
3943:b
3938:a
3896:c
3891:a
3882:)
3880:k
3875:i
3870:e
3865:d
3860:a
3858:(
3844:c
3839:b
3834:a
3661:b
3656:a
3644:b
3639:a
3567:b
3562:a
3435:k
3430:j
3425:h
3420:e
3415:d
3410:a
3373:b
3368:a
3316:f
3311:e
3306:d
3301:c
3296:b
3291:a
3279:C
3274:B
3269:A
3252:P
3247:L
3242:E
3164:f
3159:e
3154:d
3149:c
3144:b
3139:a
3097:d
3092:c
3087:b
3082:a
3025:B
3020:A
2938:B
2933:A
2906:d
2901:c
2896:b
2891:a
2869:a
2837:ε
2832:δ
2827:γ
2772:)
2754:e
2747:t
2740:v
2678:e
2671:t
2664:v
2651:.
2621:.
2601:.
2589::
2572:.
2552::
2534:.
2514::
2497:.
2465:.
2441:.
2419::
2413:6
2392:.
2366:.
2336:.
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2287:.
2263::
2257:7
2236:.
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2187:.
2173::
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2105:.
2091::
2064:.
2050::
2023:.
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1982:.
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1927:.
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1818:.
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1780:.
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1739::
1731::
1704:.
1686:.
1540:.
1528:,
1522:,
1347:(
354:)
251:)
234::
76:)
70:(
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61:(
47:.
20:)
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