326:
303:
200:
225:
584:
577:
4827:
332:
231:
1263:
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor
63:
3236:
1834:"Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8"
2375:
1758:
Fernández-Ruiz E, Pardo-Manuel de
Villena F, Rubio MA, Corbí AL, Rodriguez de Córdoba S, Sánchez-Madrid F (1992). "Mapping of the human VLA-alpha 4 gene to chromosome 2q31-q32".
339:
238:
3226:
1406:
Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis".
4807:
3206:
977:
161:
958:
4868:
4068:
2392:
2368:
2294:
4674:
1725:"Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY"
3799:
3787:
3565:
2104:"The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit"
3851:
3846:
3792:
3572:
2353:
1553:
1374:
2236:"Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)"
1356:
4897:
4887:
3305:
3231:
2361:
1795:
Rubio M, Nueda A, Vara A, Corbí Lopez AL (1992). "A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4".
4412:
4334:
4329:
4324:
4319:
3246:
1185:
325:
2311:
1484:"A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration"
4299:
1192:
302:
3535:
1392:
1591:
Oostendorp RA, Dörmer P (1997). "VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells".
4103:
3597:
3283:
2008:"The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function"
1343:
1322:
3742:
3278:
2137:
Gailit J, Pierschbacher M, Clark RA (1993). "Expression of functional alpha 4 beta 1 integrin by human dermal fibroblasts".
1339:
2317:
2051:"The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis"
224:
199:
60:
4861:
4239:
3711:
3706:
3651:
3385:
2834:
1318:
3933:
3656:
141:
3251:
2301:
1273:
1686:
O'Connor P (2007). "Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis".
338:
237:
3963:
2388:
2168:"Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation"
1252:
331:
230:
4902:
2829:
1528:
Humphries MJ, Sheridan J, Mould AP, Newham P (1995). "Mechanisms of VCAM-1 and
Fibronectin Binding to Integrin α
1620:
Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors".
4854:
4013:
2908:
2288:
1022:
149:
1912:"Coexpression of two fibronectin receptors, VLA-4 and VLA-5, by immature human erythroblastic precursor cells"
1482:
Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002).
4405:
3977:
1003:
4769:
4743:
4738:
4733:
4658:
4648:
4589:
3320:
3315:
3310:
3300:
2607:
2535:
4594:
2664:
2582:
1264:
undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
4706:
4690:
4621:
3901:
3614:
2205:
Szabo M, McIntyre BW (1996). "Identification of two variants of the human integrin alpha 4 subunit".
2062:
1966:
213:
128:
3928:
3747:
2323:
1147:
1096:
4892:
4398:
3335:
3069:
2265:
1820:
1783:
1711:
1674:
1571:
1293:
173:
1168:
1143:
1117:
1092:
2330:
2257:
2222:
2193:
2154:
2125:
2090:
2037:
1994:
1941:
1898:
1863:
1812:
1775:
1746:
1703:
1666:
1637:
1608:
1559:
1549:
1505:
1464:
1423:
583:
121:
53:
4838:
4695:
4626:
4556:
4551:
4505:
4108:
3841:
3762:
3325:
2518:
2444:
2247:
2214:
2183:
2175:
2146:
2115:
2080:
2070:
2027:
2019:
1984:
1974:
1931:
1923:
1888:
1853:
1845:
1804:
1767:
1736:
1695:
1658:
1629:
1600:
1541:
1495:
1454:
1415:
418:
349:
293:
248:
576:
169:
4168:
2704:
2699:
2622:
2305:
1583:
393:
2284:
1393:"Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)"
2066:
1970:
4790:
4785:
4764:
3953:
3375:
2886:
2689:
2188:
2167:
2023:
1858:
1833:
1443:"Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding"
4826:
2120:
2103:
2085:
2050:
2032:
2007:
1936:
1911:
1893:
1876:
1741:
1724:
1633:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
665:
660:
655:
650:
645:
640:
635:
630:
625:
4881:
3923:
3380:
2471:
2339:
2218:
1989:
1954:
1662:
612:
1824:
1787:
1715:
1678:
4279:
3587:
3577:
3108:
3074:
2269:
411:
190:
1540:. Novartis Foundation Symposia. Vol. 189. pp. 177–91, discussion 191–9.
153:
2150:
177:
4289:
3938:
3716:
3691:
3390:
3012:
2938:
2412:
2252:
2235:
1832:
Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R (1990).
1649:
Rose DM, Han J, Ginsberg MH (2003). "Alpha4 integrins and the immune response".
1379:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1361:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1877:"Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage"
1545:
1441:
Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001).
494:
4834:
4219:
3943:
3624:
3365:
3241:
2874:
2869:
2864:
2719:
2503:
1604:
310:
207:
157:
1699:
1296:, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis
4058:
4053:
4048:
4038:
4033:
4028:
4023:
2075:
1979:
1419:
922:
554:
432:
377:
364:
276:
263:
165:
2298:
1849:
1808:
1771:
1707:
1670:
1509:
1500:
1483:
1468:
1459:
1442:
1427:
2261:
2226:
2197:
2158:
2129:
2094:
2041:
1998:
1945:
1902:
1867:
1816:
1779:
1750:
1641:
1612:
1563:
1232:
1227:
4421:
4364:
4264:
4078:
4063:
3266:
3261:
3169:
2859:
1281:
1248:
1216:
1067:
1048:
4314:
4309:
4304:
4204:
4018:
4008:
3835:
3814:
3809:
3777:
3582:
3502:
3497:
3492:
3487:
3482:
3400:
3093:
2933:
2928:
2923:
2918:
2913:
2384:
2344:
2334:
1034:
989:
2179:
1927:
1536: : Implications for Integrin Function and Rational Drug Design".
98:
94:
90:
86:
82:
4599:
4485:
4480:
4254:
4214:
4199:
4183:
4178:
4158:
4153:
4088:
3896:
3866:
3830:
3821:
3634:
3602:
3466:
3461:
3431:
3410:
3370:
3330:
3196:
3174:
3133:
3057:
3052:
3047:
3042:
3037:
3032:
2901:
2896:
2891:
2839:
2824:
2694:
2684:
2647:
2642:
2560:
2555:
1277:
1200:
944:
17:
2234:
Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (1996).
4753:
4748:
4711:
4679:
4653:
4566:
4561:
4546:
4515:
4510:
4500:
4495:
4490:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4379:
4354:
4274:
4269:
4259:
4249:
4234:
4229:
4224:
4209:
4163:
4148:
4113:
4098:
4093:
4083:
4003:
3998:
3993:
3972:
3968:
3958:
3871:
3772:
3767:
3726:
3676:
3671:
3666:
3661:
3646:
3639:
3619:
3607:
3550:
3545:
3540:
3530:
3525:
3518:
3456:
3446:
3441:
3436:
3426:
3405:
3395:
3360:
3355:
3350:
3345:
3340:
3295:
3290:
3256:
3221:
3216:
3211:
3201:
3189:
3184:
3164:
3159:
3154:
3149:
3103:
2995:
2990:
2809:
2793:
2786:
2781:
2776:
2771:
2766:
2761:
2736:
2714:
2709:
2602:
2528:
2523:
2513:
907:
903:
4757:
4715:
4699:
4683:
4630:
4603:
4541:
4536:
4531:
4374:
4369:
4359:
4349:
4344:
4339:
4294:
4284:
4244:
4173:
4143:
4138:
4133:
4128:
4123:
4118:
4073:
4043:
3948:
3916:
3911:
3891:
3881:
3876:
3861:
3856:
3757:
3752:
3721:
3701:
3696:
3686:
3681:
3560:
3513:
3473:
3128:
3123:
3118:
3113:
3098:
3089:
3084:
3079:
3064:
3022:
3017:
3007:
3002:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2950:
2945:
2881:
2854:
2849:
2844:
2819:
2814:
2751:
2746:
2741:
2731:
2726:
2679:
2674:
2669:
2659:
2654:
2637:
2632:
2627:
2617:
2612:
2597:
2592:
2587:
2577:
2572:
2567:
2550:
2545:
2540:
2491:
2459:
2454:
2449:
2432:
2427:
2422:
2417:
145:
4394:
2357:
1910:
Rosemblatt M, Vuillet-Gaugler MH, Leroy C, Coulombel L (1991).
1538:
Ciba
Foundation Symposium 189 - Cell Adhesion and Human Disease
592:
3886:
2498:
2486:
2481:
2476:
2466:
2439:
2407:
883:
positive regulation of vascular endothelial cell proliferation
4390:
2329:
Overview of all the structural information available in the
893:
positive regulation of endothelial cell apoptotic process
783:
cell-matrix adhesion involved in ameboidal cell migration
1955:"Characterization of the alpha 4 integrin gene promoter"
873:
cell-cell adhesion in response to extracellular stimulus
843:
negative regulation of protein homodimerization activity
401:
4842:
818:
positive regulation of leukocyte tethering or rolling
566:
1875:
Teixidó J, Parker CM, Kassner PD, Hemler ME (1992).
848:
clathrin-dependent extracellular exosome endocytosis
4778:
4726:
4667:
4641:
4614:
4582:
4575:
4524:
4428:
4192:
3986:
3735:
3419:
3142:
2802:
2400:
2166:Pujades C, Teixidó J, Bazzoni G, Hemler ME (1996).
1161:
1136:
1110:
1085:
823:
positive regulation of leukocyte cell-cell adhesion
1335:
1333:
1331:
1314:
1312:
1310:
2006:Takada Y, Elices MJ, Crouse C, Hemler ME (1989).
348:
247:
1723:Chan BM, Elices MJ, Murphy E, Hemler ME (1992).
1340:GRCm38: Ensembl release 89: ENSMUSG00000027009
4862:
4406:
2369:
8:
1251:alpha subunit. It makes up half of the α4β1
2049:Takada Y, Strominger JL, Hemler ME (1987).
1319:GRCh38: Ensembl release 89: ENSG00000115232
773:substrate adhesion-dependent cell spreading
4869:
4855:
4579:
4413:
4399:
4391:
2376:
2362:
2354:
1953:Rosen GD, Birkenmeier TM, Dean DC (1991).
918:
828:positive regulation of leukocyte migration
608:
389:
288:
185:
71:
2393:list of human clusters of differentiation
2287:at the U.S. National Library of Medicine
2251:
2187:
2119:
2084:
2074:
2031:
1988:
1978:
1935:
1892:
1857:
1740:
1499:
1458:
1306:
863:cell-cell adhesion mediated by integrin
758:positive regulation of T cell migration
27:Mammalian protein found in Homo sapiens
2102:Hemler ME, Huang C, Schwarz L (1987).
1579:
1569:
778:cellular response to cytokine stimulus
132:, CD49D, IA4, integrin subunit alpha 4
31:
353:
314:
309:
252:
211:
206:
7:
4823:
4821:
1688:Expert Opinion on Biological Therapy
868:axonogenesis involved in innervation
808:integrin-mediated signaling pathway
666:protein heterodimerization activity
4841:. You can help Knowledge (XXG) by
4808:cell surface receptor deficiencies
2024:10.1002/j.1460-2075.1989.tb03516.x
1158:
1133:
1107:
1082:
1058:
1039:
1013:
994:
968:
949:
571:
489:
427:
406:
25:
878:cellular response to amyloid-beta
763:extracellular matrix organization
4825:
2343:(Human Integrin alpha-4) at the
1663:10.1034/j.1600-065X.2002.18611.x
582:
575:
337:
330:
324:
301:
236:
229:
223:
198:
748:endodermal cell differentiation
793:leukocyte tethering or rolling
768:heterotypic cell-cell adhesion
687:integral component of membrane
651:cell adhesion molecule binding
593:More reference expression data
555:More reference expression data
1:
2174:. 313. ( Pt 3) (3): 899–908.
2121:10.1016/S0021-9258(18)61504-2
1894:10.1016/S0021-9258(18)46014-0
1742:10.1016/S0021-9258(18)42453-2
1634:10.1016/S0962-8924(98)01344-0
803:regulation of immune response
707:integrin alpha4-beta7 complex
322:
221:
4668:Leukocyte-adhesion receptor:
2219:10.1016/0161-5890(96)00001-6
2151:10.1111/1523-1747.ep12470011
2055:Proc. Natl. Acad. Sci. U.S.A
1959:Proc. Natl. Acad. Sci. U.S.A
838:leukocyte cell-cell adhesion
4898:Clusters of differentiation
4888:Genes on human chromosome 2
4727:Very late antigen receptor:
2389:clusters of differentiation
2253:10.4049/jimmunol.157.5.2039
888:neuron projection extension
4919:
4820:
2322:gene details page in the
1546:10.1002/9780470514719.ch13
1253:lymphocyte homing receptor
732:protein-containing complex
4803:
1605:10.3109/10428199709055581
1375:"Mouse PubMed Reference:"
1357:"Human PubMed Reference:"
1231:
1226:
1222:
1215:
1199:
1186:Chr 2: 181.46 – 181.54 Mb
1180:
1165:
1140:
1129:
1114:
1089:
1078:
1065:
1061:
1046:
1042:
1033:
1020:
1016:
1001:
997:
988:
975:
971:
956:
952:
943:
928:
921:
917:
901:
611:
607:
590:
574:
565:
552:
501:
492:
439:
430:
400:
392:
388:
371:
358:
321:
300:
291:
287:
270:
257:
220:
197:
188:
184:
139:
136:
126:
119:
114:
79:
74:
57:
52:
47:
43:
39:
34:
2289:Medical Subject Headings
1700:10.1517/14712598.7.1.123
1272:CD49d has been shown to
661:C-X3-C chemokine binding
2297:Info with links in the
2076:10.1073/pnas.84.10.3239
1980:10.1073/pnas.88.10.4094
1420:10.1242/jcs.113.13.2385
1193:Chr 2: 79.09 – 79.16 Mb
631:protein antigen binding
529:muscle layer of urethra
525:external carotid artery
521:internal carotid artery
2299:Cell Migration Gateway
1850:10.1083/jcb.110.6.2145
1809:10.1002/eji.1830220434
1772:10.1002/eji.1830220243
1501:10.1074/jbc.M110928200
1460:10.1074/jbc.M102665200
753:B cell differentiation
517:mesenteric lymph nodes
513:lumbar spinal ganglion
4779:Vitronectin receptor:
4642:Fibronectin receptor:
4595:Glycoprotein IIb/IIIa
4583:Cytoadhesin receptor:
682:extracellular exosome
4770:Integrin alpha6beta1
4744:Integrin alpha3beta1
4739:Integrin alpha2beta1
4734:Integrin alpha1beta1
4707:Integrin alphaXbeta2
4691:Macrophage-1 antigen
4659:Integrin alpha5beta1
4654:Integrin alpha4beta1
4649:Integrin alpha2beta1
4622:Macrophage-1 antigen
4615:Fibrinogen receptor:
4590:Integrin alpha6beta4
2316:genome location and
788:cell-matrix adhesion
355:2 C3|2 47.38 cM
316:Chromosome 2 (mouse)
214:Chromosome 2 (human)
75:List of PDB id codes
48:Available structures
2324:UCSC Genome Browser
2139:J. Invest. Dermatol
2067:1987PNAS...84.3239T
1971:1991PNAS...88.4094R
858:receptor clustering
813:leukocyte migration
656:coreceptor activity
646:fibronectin binding
479:epithelium of colon
2304:2014-12-11 at the
1414:(Pt 13): 2385–97.
1294:Carotegrast methyl
1023:ENSMUSG00000027009
741:Biological process
727:neuronal cell body
675:Cellular component
619:Molecular function
4850:
4849:
4815:
4814:
4799:
4798:
4388:
4387:
2213:(17–18): 1453–4.
2180:10.1042/bj3130899
1928:10.1172/JCI115002
1555:978-0-470-51471-9
1242:
1241:
1238:
1237:
1211:
1210:
1176:
1175:
1155:
1154:
1125:
1124:
1104:
1103:
1074:
1073:
1055:
1054:
1029:
1028:
1010:
1009:
984:
983:
965:
964:
913:
912:
636:metal ion binding
603:
602:
599:
598:
561:
560:
548:
547:
486:
485:
447:bone marrow cells
384:
383:
283:
282:
178:ITGA4 - orthologs
110:
109:
106:
105:
58:Ortholog search:
16:(Redirected from
4910:
4903:Immunology stubs
4871:
4864:
4857:
4829:
4822:
4580:
4415:
4408:
4401:
4392:
2378:
2371:
2364:
2355:
2273:
2255:
2230:
2201:
2191:
2162:
2133:
2123:
2098:
2088:
2078:
2045:
2035:
2002:
1992:
1982:
1949:
1939:
1906:
1896:
1871:
1861:
1828:
1791:
1754:
1744:
1719:
1682:
1645:
1622:Trends Cell Biol
1616:
1587:
1581:
1577:
1575:
1567:
1514:
1513:
1503:
1494:(23): 20887–94.
1479:
1473:
1472:
1462:
1438:
1432:
1431:
1403:
1397:
1396:
1389:
1383:
1382:
1371:
1365:
1364:
1353:
1347:
1337:
1326:
1316:
1224:
1223:
1195:
1188:
1171:
1159:
1150:
1134:
1130:RefSeq (protein)
1120:
1108:
1099:
1083:
1059:
1040:
1014:
995:
969:
950:
919:
833:import into cell
712:integrin complex
609:
595:
586:
579:
572:
557:
497:
495:Top expressed in
490:
475:secondary oocyte
435:
433:Top expressed in
428:
407:
390:
380:
367:
356:
341:
334:
328:
317:
305:
289:
279:
266:
255:
240:
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131:
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101:
72:
66:
45:
44:
32:
21:
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4909:
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4878:
4877:
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4875:
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4722:
4663:
4637:
4610:
4571:
4520:
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4389:
4384:
4188:
3982:
3731:
3415:
3138:
2798:
2396:
2382:
2351:
2306:Wayback Machine
2281:
2276:
2233:
2204:
2165:
2136:
2101:
2061:(10): 3239–43.
2048:
2005:
1952:
1916:J. Clin. Invest
1909:
1874:
1831:
1803:(4): 1099–102.
1797:Eur. J. Immunol
1794:
1760:Eur. J. Immunol
1757:
1735:(12): 8366–70.
1722:
1685:
1648:
1619:
1599:(5–6): 423–35.
1590:
1578:
1568:
1556:
1535:
1531:
1527:
1523:
1521:Further reading
1518:
1517:
1481:
1480:
1476:
1453:(44): 40903–9.
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1317:
1308:
1303:
1290:
1270:
1261:
1233:View/Edit Mouse
1228:View/Edit Human
1191:
1184:
1181:Location (UCSC)
1167:
1146:
1142:
1116:
1095:
1091:
1004:ENSG00000115232
897:
736:
717:plasma membrane
670:
641:antigen binding
626:protein binding
591:
581:
580:
553:
544:
539:
535:
531:
527:
523:
519:
515:
511:
507:
493:
482:
477:
473:
471:trabecular bone
469:
465:
461:
457:
453:
449:
445:
431:
375:
362:
354:
344:
343:
342:
335:
315:
292:Gene location (
274:
261:
253:
243:
242:
241:
234:
212:
189:Gene location (
140:
127:
120:
81:
59:
28:
23:
22:
15:
12:
11:
5:
4916:
4914:
4906:
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4848:
4847:
4830:
4813:
4812:
4804:
4801:
4800:
4797:
4796:
4794:
4793:
4791:Alpha-v beta-5
4788:
4786:Alpha-v beta-3
4782:
4780:
4776:
4775:
4773:
4772:
4767:
4765:Alpha-5 beta-1
4762:
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2279:External links
2277:
2275:
2274:
2246:(5): 2039–47.
2231:
2202:
2163:
2134:
2099:
2046:
2003:
1965:(10): 4094–8.
1950:
1907:
1887:(3): 1786–91.
1872:
1844:(6): 2145–55.
1829:
1792:
1755:
1720:
1683:
1646:
1617:
1593:Leuk. Lymphoma
1588:
1580:|journal=
1554:
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729:
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699:
697:focal adhesion
694:
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398:
397:
394:RNA expression
386:
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3489:
3486:
3484:
3480:
3477:
3475:
3472:
3468:
3465:
3463:
3460:
3458:
3455:
3454:
3453:
3450:
3448:
3445:
3443:
3440:
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3435:
3433:
3430:
3428:
3425:
3424:
3422:
3418:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
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3339:
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3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
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3299:
3297:
3294:
3292:
3289:
3285:
3282:
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3277:
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3265:
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3260:
3259:
3258:
3255:
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3248:
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3243:
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3225:
3223:
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3213:
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3208:
3205:
3203:
3200:
3198:
3195:
3191:
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3183:
3182:
3181:
3178:
3176:
3173:
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3156:
3153:
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3148:
3147:
3145:
3141:
3135:
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3117:
3115:
3112:
3110:
3107:
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3097:
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3076:
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3019:
3016:
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3009:
3006:
3004:
3001:
2997:
2994:
2992:
2989:
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2979:
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2898:
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2823:
2821:
2818:
2816:
2813:
2811:
2808:
2807:
2805:
2801:
2795:
2792:
2788:
2785:
2783:
2780:
2778:
2775:
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2768:
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2755:
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2730:
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2721:
2718:
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2702:
2701:
2698:
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2693:
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2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
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2656:
2653:
2649:
2646:
2644:
2641:
2640:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2562:
2559:
2557:
2554:
2553:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2511:
2510:
2507:
2505:
2502:
2500:
2497:
2493:
2490:
2489:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2461:
2458:
2456:
2453:
2451:
2448:
2447:
2446:
2443:
2441:
2438:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2410:
2409:
2406:
2405:
2403:
2399:
2394:
2390:
2386:
2379:
2374:
2372:
2367:
2365:
2360:
2359:
2356:
2352:
2346:
2342:
2341:
2336:
2332:
2328:
2325:
2321:
2320:
2315:
2314:
2309:
2307:
2303:
2300:
2296:
2293:
2290:
2286:
2285:CD49d+antigen
2283:
2282:
2278:
2271:
2267:
2263:
2259:
2254:
2249:
2245:
2241:
2237:
2232:
2228:
2224:
2220:
2216:
2212:
2208:
2203:
2199:
2195:
2190:
2185:
2181:
2177:
2173:
2169:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2135:
2131:
2127:
2122:
2117:
2114:(7): 3300–9.
2113:
2109:
2108:J. Biol. Chem
2105:
2100:
2096:
2092:
2087:
2082:
2077:
2072:
2068:
2064:
2060:
2056:
2052:
2047:
2043:
2039:
2034:
2029:
2025:
2021:
2018:(5): 1361–8.
2017:
2013:
2009:
2004:
2000:
1996:
1991:
1986:
1981:
1976:
1972:
1968:
1964:
1960:
1956:
1951:
1947:
1943:
1938:
1933:
1929:
1925:
1921:
1917:
1913:
1908:
1904:
1900:
1895:
1890:
1886:
1882:
1881:J. Biol. Chem
1878:
1873:
1869:
1865:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1798:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1766:(2): 587–90.
1765:
1761:
1756:
1752:
1748:
1743:
1738:
1734:
1730:
1729:J. Biol. Chem
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1694:(1): 123–36.
1693:
1689:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1657:(1): 118–24.
1656:
1652:
1647:
1643:
1639:
1635:
1631:
1628:(10): 390–6.
1627:
1623:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1589:
1585:
1573:
1565:
1561:
1557:
1551:
1547:
1543:
1539:
1526:
1525:
1520:
1511:
1507:
1502:
1497:
1493:
1489:
1488:J. Biol. Chem
1485:
1478:
1475:
1470:
1466:
1461:
1456:
1452:
1448:
1447:J. Biol. Chem
1444:
1437:
1434:
1429:
1425:
1421:
1417:
1413:
1409:
1402:
1399:
1394:
1388:
1385:
1380:
1376:
1370:
1367:
1362:
1358:
1352:
1349:
1345:
1341:
1336:
1334:
1332:
1328:
1324:
1320:
1315:
1313:
1311:
1307:
1300:
1295:
1292:
1291:
1287:
1285:
1283:
1279:
1275:
1267:
1265:
1258:
1256:
1254:
1250:
1246:
1234:
1229:
1225:
1221:
1218:
1214:
1207:
1205:
1202:
1198:
1194:
1190:
1187:
1183:
1179:
1172:
1170:
1164:
1160:
1157:
1151:
1149:
1145:
1139:
1135:
1132:
1128:
1121:
1119:
1113:
1109:
1106:
1100:
1098:
1094:
1088:
1084:
1081:
1079:RefSeq (mRNA)
1077:
1070:
1069:
1064:
1060:
1057:
1051:
1050:
1045:
1041:
1038:
1036:
1032:
1025:
1024:
1019:
1015:
1012:
1006:
1005:
1000:
996:
993:
991:
987:
980:
979:
974:
970:
967:
961:
960:
955:
951:
948:
946:
942:
939:
936:
934:
931:
927:
924:
920:
916:
909:
905:
900:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
853:cell adhesion
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
745:
743:
740:
739:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
679:
677:
674:
673:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
623:
621:
618:
617:
614:
613:Gene ontology
610:
606:
594:
589:
585:
578:
573:
570:
568:
564:
556:
551:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
503:
500:
496:
491:
488:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
441:
438:
434:
429:
426:
425:
422:
420:
416:
414:
413:
409:
408:
405:
403:
399:
395:
391:
387:
379:
374:
370:
366:
361:
351:
347:
340:
333:
327:
320:
312:
308:
304:
299:
295:
290:
286:
278:
273:
269:
265:
260:
250:
246:
239:
232:
226:
219:
215:
209:
205:
201:
196:
192:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
135:
130:
123:
118:
113:
102:
100:
96:
92:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
30:
19:
4843:expanding it
4832:
4817:
4805:
3906:
3826:
3804:
3782:
3629:
3592:
3555:
3508:
3478:
3451:
3273:
3179:
3027:
2756:
2508:
2350:
2338:
2318:
2312:
2243:
2239:
2210:
2207:Mol. Immunol
2206:
2171:
2145:(3): 323–8.
2142:
2138:
2111:
2107:
2058:
2054:
2015:
2011:
1962:
1958:
1919:
1915:
1884:
1880:
1841:
1838:J. Cell Biol
1837:
1800:
1796:
1763:
1759:
1732:
1728:
1691:
1687:
1654:
1651:Immunol. Rev
1650:
1625:
1621:
1596:
1592:
1537:
1491:
1487:
1477:
1450:
1446:
1436:
1411:
1407:
1401:
1387:
1378:
1369:
1360:
1351:
1271:
1268:Interactions
1262:
1244:
1243:
1166:
1148:NP_001303241
1141:
1115:
1097:NM_001316312
1090:
1066:
1047:
1021:
1002:
976:
957:
937:
932:
702:cell surface
417:
410:
275:181,538,940
262:181,457,202
137:External IDs
80:
29:
1922:(1): 6–11.
1408:J. Cell Sci
722:growth cone
541:human fetus
537:granulocyte
451:granulocyte
376:79,163,467
363:79,085,770
115:Identifiers
4882:Categories
4835:immunology
2391:(see also
2240:J. Immunol
2172:Biochem. J
1346:, May 2017
1325:, May 2017
1301:References
798:diapedesis
463:lymph node
421:(ortholog)
158:HomoloGene
4893:Integrins
4806:see also
4422:Integrins
1582:ignored (
1572:cite book
1169:NP_034706
1144:NP_000876
1118:NM_010576
1093:NM_000885
923:Orthologs
166:GeneCards
2385:Proteins
2302:Archived
1825:83613615
1788:86449765
1716:73319319
1708:17150024
1679:37850994
1671:12234367
1510:11919182
1469:11533025
1428:10852818
1342:–
1321:–
1288:See also
1282:Paxillin
1274:interact
1259:Function
1249:integrin
1217:Wikidata
902:Sources:
692:membrane
455:appendix
443:monocyte
4193:301–350
3987:251–300
3939:CD240CE
3736:201–250
3420:151–200
3143:101–150
2345:PDBe-KB
2335:UniProt
2270:1977096
2262:8757325
2227:8643114
2198:8611173
2189:1216996
2159:8440915
2130:3546305
2095:3033641
2063:Bibcode
2042:2788572
1999:2034655
1967:Bibcode
1946:1824634
1903:1730718
1868:1693624
1859:2116116
1817:1551405
1780:1537388
1751:1373725
1642:9789327
1613:9086434
1564:7587632
1344:Ensembl
1323:Ensembl
1035:UniProt
990:Ensembl
929:Species
908:QuickGO
396:pattern
122:Aliases
4600:ITGA2B
4576:Dimers
4200:CD300A
4159:CDw293
3944:CD240D
3805:CD213a
3783:CDw210
3748:CD202b
3722:CDw199
3717:CDw198
3371:CD140b
2803:51–100
2340:P13612
2310:Human
2291:(MeSH)
2268:
2260:
2225:
2196:
2186:
2157:
2128:
2093:
2086:304844
2083:
2040:
2033:400962
2030:
2012:EMBO J
1997:
1987:
1944:
1937:294977
1934:
1901:
1866:
1856:
1823:
1815:
1786:
1778:
1749:
1714:
1706:
1677:
1669:
1640:
1611:
1562:
1552:
1508:
1467:
1426:
1278:LGALS8
1247:is an
1203:search
1201:PubMed
1068:Q00651
1049:P13612
945:Entrez
567:BioGPS
533:thymus
509:spleen
467:spleen
254:2q31.3
146:192975
4833:This
4754:CD49d
4749:VLA-4
4712:CD11c
4696:CD11b
4680:CD11a
4675:LFA-1
4627:CD11b
4604:ITGB3
4429:Alpha
4380:CD350
4375:CD349
4370:CD344
4365:CD340
4360:CD339
4355:CD338
4350:CD337
4345:CD336
4340:CD335
4335:CD334
4330:CD333
4325:CD332
4320:CD331
4315:CD329
4310:CD328
4305:CD327
4300:CD326
4295:CD325
4290:CD324
4285:CD322
4280:CD321
4275:CD320
4270:CD318
4265:CD317
4260:CD316
4255:CD315
4250:CD314
4245:CD312
4240:CD309
4235:CD307
4230:CD306
4225:CD305
4220:CD304
4215:CD303
4210:CD302
4205:CD301
4184:CD299
4179:CD298
4174:CD297
4169:CD295
4164:CD294
4154:CD292
4149:CD290
4144:CD289
4139:CD288
4134:CD286
4129:CD284
4124:CD283
4119:CD282
4114:CD281
4109:CD280
4104:CD279
4099:CD278
4094:CD276
4089:CD275
4084:CD274
4079:CD273
4074:CD272
4069:CD271
4064:CD269
4059:CD268
4054:CD267
4049:CD266
4044:CD265
4039:CD264
4034:CD263
4029:CD262
4024:CD261
4019:CD258
4014:CD257
4009:CD256
4004:CD254
3999:CD253
3994:CD252
3978:CD249
3973:CD248
3969:CD247
3964:CD246
3959:CD244
3954:CD243
3949:CD241
3934:CD239
3929:CD238
3924:CD236
3907:CD235
3902:CD234
3897:CD233
3892:CD230
3887:CD229
3882:CD228
3877:CD227
3872:CD226
3867:CD225
3862:CD224
3857:CD223
3852:CD222
3847:CD221
3842:CD220
3827:CD218
3822:CD217
3800:CD212
3778:CD209
3773:CD208
3768:CD207
3763:CD206
3758:CD205
3753:CD204
3743:CD201
3727:CD200
3712:CD197
3707:CD196
3702:CD195
3697:CD194
3692:CD193
3687:CD192
3682:CD191
3677:CD186
3672:CD185
3667:CD184
3662:CD183
3657:CD182
3652:CD181
3647:CD180
3630:CD179
3625:CD178
3620:CD177
3615:CD174
3593:CD172
3588:CD171
3583:CD170
3578:CD169
3573:CD168
3556:CD167
3551:CD166
3546:CD164
3541:CD163
3536:CD162
3531:CD161
3526:CD160
3509:CD159
3479:CD158
3474:CD157
3452:CD156
3447:CD155
3442:CD154
3437:CD153
3432:CD152
3427:CD151
3411:CD150
3406:CD148
3401:CD147
3396:CD146
3391:CD144
3386:CD143
3381:CD142
3376:CD141
3366:CD138
3361:CD137
3356:CD136
3351:CD135
3346:CD134
3341:CD133
3336:CD132
3331:CD131
3326:CD130
3321:CD129
3316:CD127
3311:CD126
3306:CD125
3301:CD124
3296:CD123
3291:CD122
3274:CD121
3257:CD120
3252:CD119
3247:CD118
3242:CD117
3237:CD116
3232:CD115
3227:CD114
3222:CD113
3217:CD112
3212:CD111
3207:CD110
3202:CD109
3197:CD108
3180:CD107
3175:CD106
3170:CD105
3165:CD104
3160:CD103
3155:CD102
3150:CD101
3134:CD100
2319:ITGA4
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