1232:. Secondly, increased levels of P-selectin mRNA and protein are induced by inflammatory mediators such as tumor necrosis factor-a (TNF-a), LPS, and interleukin-4 (IL-4). Although TNF-a and LPS increase levels of both mRNA and protein in murine models, they do not appear to affect mRNA in human endothelial cells, while IL-4 increases P-selectin transcription in both species. The elevated synthesis of P-selectin may play an important role in the delivery of protein to the cell surface. In ischemic stroke patients, plasma P-selectin concentration was reported to be highly correlated to plasminogen activator inhibitor-1 activity and tissue plasminogen activator activity.
1461:
the use of heparin as anti-cancer agent is limited because of its risk, which might induce adverse bleeding complications. Given those reasons, development of new compounds that target P-selectin is now emerging for cancer therapy. Among them, the inhibitory activity of semisynthetic sulfated tri mannose C-C-linked dimers (STMCs) to P-selectin was shown by the attenuation of tumor metastasis in vivo animal model, indicating the inhibition of interaction between tumor cell and endothelial cell is significant for blocking tumor dissemination.
331:
308:
205:
230:
1412:, and helps cancer cells invade into the bloodstream for metastasis and provides local multiple growth factors, respectively. Moreover, platelets facilitate tumor metastasis by forming complexes with tumour cells and leukocytes in the vasculature, thus preventing recognition by macrophages. This is thought to contribute to the seeding of tumour microemboli in distant organs. In vivo mice experiments have shown that a reduction in circulating platelets could reduce cancer metastasis.
3063:
3033:
3078:
582:
3048:
337:
236:
42:
1460:
Heparin has long been known to represent antiheparanase activity that is to keep an endoglycosidase from degrading heparan sulfate, one of the glycosaminoglycans, and to effectively inhibit P-selectin. Despite a striking effect of heparin on tumor progression shown in a number of clinical trials,
1215:
in humans. P-selectin is constitutively expressed in megakaryocytes (the precursor of platelets) and endothelial cells. P-selectin expression is induced by two distinct mechanisms. First, P-selectin is synthesized by megakaryocytes and endothelial cells, where it is sorted into the membranes of
1384:
P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In a quiescent platelet, P-selectin is located on the inner wall of Ξ±-granules. Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane
68:
1292:(same as complement regulatory proteins: CRP) having short consensus repeats (~60 amino acids). The number of CRP repeats is the major feature differentiating the type of selectin in extracellular region. In human, P-selectin has nine repeats while
1385:
flipping" where the platelet releases Ξ±- and dense granules and the inner walls of the granules are exposed on the outside of the cell. The P-selectin then promotes platelet aggregation through platelet-fibrin and platelet-platelet binding.
2026:
Woltmann G, McNulty CA, Dewson G, Symon FA, Wardlaw AJ (May 2000). "Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow".
1381:-sensitive, endo-beta-galactosidase-resistant structures, clearly different from those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses.
1202:
Other names for P-selectin include CD62P, Granule
Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first identified in endothelial cells in 1989.
2479:
Monzavi-Karbassi B, Stanley JS, Hennings L, Jousheghany F, Artaud C, Shaaf S, et al. (March 2007). "Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines".
2195:
Wein M, Sterbinsky SA, Bickel CA, Schleimer RP, Bochner BS (March 1995). "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin".
3979:
2799:
Varki NM, Varki A (February 2002). "Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans".
3118:
1374:
is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca-independent pathway involved in the release of P-selectin.
1472:
is a monoclonal antibody against P-selectin. which has now been approved by
Novartis on November 15, 2019 for the indication of vaso-occlusive crisis in sickle cell patients.
1344:, in which it mediates tethering and adhesion of these cells. However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin.
2284:"E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung"
1795:"Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140"
1705:"Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells"
1425:(sLe(x)) is expressed on the surface of tumor cells and can be recognized by E-selectin and P-selectin, playing on a key role in metastasis of the tumor. However, in the
5155:
1457:
is of interest in P-selectin mediated tumor metastasis. Selective removal of mucin results in reduced interaction between P-selectin and platelets in vivo and in vitro.
344:
243:
3969:
2894:
Chen M, Geng JG (2006). "P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis".
2331:
Chen M, Geng JG (2006). "P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis".
3062:
3949:
895:
876:
166:
4811:
3135:
3111:
3032:
5304:
3077:
4542:
1368:
by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface.
1615:"GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies"
4530:
4308:
5148:
4594:
4589:
4535:
4315:
3096:
3012:
1560:
65:
1836:"Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes"
1542:
5694:
4048:
3974:
3104:
3047:
5077:
5072:
5067:
5062:
3989:
1099:
330:
1106:
5673:
5042:
2148:"Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP"
1664:"The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction"
307:
5141:
4278:
1433:, E-selectin reactivity is sLe(x) dependent while P-selectin reactivity is sLe(x)-independent, suggesting P-selectin binding is
5699:
5203:
4846:
4340:
4026:
2379:"Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis"
1529:
1508:
4485:
4021:
2566:"Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species"
1525:
2607:"The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials"
229:
204:
5193:
4982:
4454:
4449:
4394:
4128:
3577:
1504:
4676:
4399:
1983:
Wang J, Li J, Liu Q (August 2005). "Association between platelet activation and fibrinolysis in acute stroke patients".
1162:
146:
3994:
343:
242:
5621:
4706:
3131:
2062:
Vestweber D, Blanks JE (January 1999). "Mechanisms that regulate the function of the selectins and their ligands".
3572:
3005:
336:
235:
5653:
4756:
3651:
2942:
940:
154:
2836:
Furie B, Furie BC (April 2004). "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation".
1746:"Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway"
4720:
1325:
921:
1241:
5383:
5176:
5168:
4063:
4058:
4053:
4043:
3350:
3278:
2099:"Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors"
1365:
1245:
1229:
1196:
1188:
1176:
5360:
3407:
3325:
1261:
5332:
5318:
4644:
4357:
2998:
2390:
1393:
1192:
218:
133:
2865:
Cambien B, Wagner DD (April 2004). "A new role in hemostasis for the adhesion receptor P-selectin".
5197:
4671:
4490:
1442:
1061:
5704:
4078:
3812:
2919:
2824:
2636:
2505:
2461:
2356:
2008:
1434:
178:
1082:
1057:
1031:
1010:
2233:"Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells"
2097:
Lorenzon P, Vecile E, Nardon E, Ferrero E, Harlan JM, Tedesco F, et al. (September 1998).
2970:
2949:
2911:
2882:
2853:
2816:
2787:
2734:
2685:
2628:
2587:
2546:
2497:
2453:
2418:
2348:
2313:
2264:
2213:
2177:
2128:
2079:
2044:
2000:
1965:
1916:
1865:
1816:
1775:
1726:
1685:
1644:
1595:
1446:
1357:
126:
58:
5133:
2703:
Ataga KI, Kutlar A, Kanter J, Liles D, Cancado R, Friedrisch J, et al. (February 2017).
1662:
Herrmann SM, Ricard S, Nicaud V, Mallet C, Evans A, Ruidavets JB, et al. (August 1998).
1408:. P-selectin is expressed on the surface of both stimulated endothelial cells and activated
5498:
5164:
4851:
4584:
4505:
4068:
3261:
3187:
2903:
2874:
2845:
2808:
2777:
2769:
2724:
2716:
2675:
2667:
2618:
2577:
2536:
2489:
2445:
2408:
2398:
2340:
2303:
2295:
2254:
2244:
2205:
2167:
2159:
2118:
2110:
2071:
2036:
1992:
1955:
1947:
1906:
1896:
1855:
1847:
1806:
1765:
1757:
1716:
1675:
1634:
1626:
1587:
423:
354:
298:
253:
2231:
Martinelli S, Chen EJ, Clarke F, Lyck R, Affentranger S, Burkhardt JK, et al. (2013).
4911:
3447:
3442:
3365:
2656:"Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase"
1416:
1317:
1285:
1225:
581:
398:
174:
2564:
Bar-Ner M, Eldor A, Wasserman L, Matzner Y, Cohen IR, Fuks Z, et al. (August 1987).
2525:"P-selectin mediates metastatic progression through binding to sulfatides on tumor cells"
2436:
Gasic GJ (1984). "Role of plasma, platelets, and endothelial cells in tumor metastasis".
1300:
has only two. P-selectin is anchored in transmembrane region that is followed by a short
1276:
region of P-selectin is composed of three different domains like other selectin types; a
2394:
1885:"Differential regulation of human and murine P-selectin expression and function in vivo"
4696:
4118:
3629:
3432:
2782:
2757:
2729:
2704:
2680:
2655:
2308:
2283:
2259:
2232:
2172:
2147:
2123:
2098:
1960:
1935:
1911:
1884:
1860:
1835:
1257:
2938:
1811:
1794:
1770:
1745:
1639:
1614:
810:
805:
800:
795:
790:
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724:
719:
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673:
668:
663:
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648:
643:
638:
633:
628:
623:
5688:
5480:
4666:
4123:
3214:
2979:
2958:
2623:
2606:
2413:
2378:
1591:
1469:
1277:
1273:
1265:
1253:
1217:
610:
2923:
2509:
2465:
2360:
2012:
5451:
5447:
5443:
5439:
5232:
5022:
4330:
4320:
3851:
3817:
2828:
2640:
1430:
1361:
416:
195:
2075:
158:
2878:
2849:
1996:
1316:) which is expressed on almost all leukocytes, although P-selectin also binds to
182:
5524:
5457:
5417:
5407:
5032:
4681:
4459:
4434:
4133:
3755:
3681:
3155:
2582:
2565:
2209:
1565:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1547:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1419:
1301:
1269:
1180:
806:
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
2383:
Proceedings of the
National Academy of Sciences of the United States of America
2163:
1613:
McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (July 1989).
1211:
P-selectin is located on chromosome 1q21-q24, spans > 50 kb and contains 17
499:
5630:
5596:
5591:
5514:
5435:
4962:
4686:
4367:
4108:
3984:
3612:
3607:
3462:
3246:
2907:
2344:
2040:
1405:
1377:
Ligands for P-selectin on eosinophils and neutrophils are similar sialylated,
1353:
1337:
1333:
1329:
1297:
1293:
1289:
1281:
315:
212:
162:
2249:
1721:
1704:
1240:
P-selectin is found in endothelial cells and platelets where it is stored in
5427:
5227:
4801:
4796:
4791:
4781:
4776:
4771:
4766:
2541:
2524:
1883:
Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, et al. (December 2010).
1438:
1409:
1184:
840:
559:
437:
382:
369:
281:
268:
170:
2915:
2886:
2857:
2820:
2773:
2738:
2689:
2632:
2550:
2501:
2422:
2403:
2352:
2317:
2299:
2268:
2181:
2114:
2048:
2004:
1969:
1951:
1936:"Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention"
1920:
1680:
1663:
1449:(GAG). Its activity in tumor metastasis has been probed by the addition of
746:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
2791:
2720:
2591:
2457:
2377:
Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A (March 2001).
2217:
2132:
2083:
1869:
1851:
1820:
1779:
1730:
1689:
1648:
1599:
1146:
1141:
5636:
5583:
5392:
5296:
5185:
5107:
5007:
4821:
4806:
4009:
4004:
3912:
3602:
2812:
1901:
1578:
Ryan US, Worthington RE (February 1992). "Cell-cell contact mechanisms".
1481:
1378:
1371:
1341:
1321:
1249:
1221:
1130:
985:
966:
3071:: Crystal structure of P-selectin lectin/EGF domains complexed with SLeX
2705:"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease"
2654:
Borsig L, Vlodavsky I, Ishai-Michaeli R, Torri G, Vismara E (May 2011).
1761:
1744:
Disdier M, Morrissey JH, Fugate RD, Bainton DF, McEver RP (March 1992).
5057:
5052:
5047:
4947:
4761:
4751:
4578:
4557:
4552:
4520:
4325:
4245:
4240:
4235:
4230:
4225:
4143:
3836:
3676:
3671:
3666:
3661:
3656:
3127:
2984:
2974:
2963:
2953:
2671:
2449:
1450:
1422:
1312:
The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (
952:
907:
2493:
1630:
103:
99:
95:
91:
87:
41:
5493:
5364:
5254:
5217:
5207:
4997:
4957:
4942:
4926:
4921:
4901:
4896:
4831:
4639:
4609:
4573:
4564:
4377:
4345:
4209:
4204:
4174:
4153:
4113:
4073:
3939:
3917:
3876:
3800:
3795:
3790:
3785:
3780:
3775:
3644:
3639:
3634:
3582:
3567:
3437:
3427:
3390:
3385:
3303:
3298:
1313:
1114:
862:
17:
1183:
cells, which line the inner surface of blood vessels, and activated
2758:"Knowledge-based model building of proteins: concepts and examples"
5668:
5645:
5641:
5569:
5559:
5554:
5549:
5544:
5539:
5488:
5368:
5350:
5346:
5336:
5322:
5308:
5284:
5279:
5274:
5269:
5264:
5259:
5242:
5237:
5211:
5122:
5097:
5017:
5012:
5002:
4992:
4977:
4972:
4967:
4952:
4906:
4891:
4856:
4841:
4836:
4826:
4746:
4741:
4736:
4715:
4711:
4701:
4614:
4515:
4510:
4469:
4419:
4414:
4409:
4404:
4389:
4382:
4362:
4350:
4293:
4288:
4283:
4273:
4268:
4261:
4199:
4189:
4184:
4179:
4169:
4148:
4138:
4103:
4098:
4093:
4088:
4083:
4038:
4033:
3999:
3964:
3959:
3954:
3944:
3932:
3927:
3907:
3902:
3897:
3892:
3846:
3738:
3733:
3552:
3536:
3529:
3524:
3519:
3514:
3509:
3504:
3479:
3457:
3452:
3345:
3271:
3266:
3256:
1834:
Hahne M, JΓ€ger U, Isenmann S, Hallmann R, Vestweber D (May 1993).
1793:
Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (May 1989).
1454:
1389:
1404:
P-selectin has a functional role in tumour metastasis similar to
1352:
P-selectin plays an essential role in the initial recruitment of
825:
821:
5663:
5658:
5625:
5564:
5534:
5529:
5519:
5469:
5465:
5461:
5412:
5354:
5340:
5326:
5312:
5247:
5222:
5117:
5112:
5102:
5092:
5087:
5082:
5037:
5027:
4987:
4916:
4886:
4881:
4876:
4871:
4866:
4861:
4816:
4786:
4691:
4659:
4654:
4634:
4624:
4619:
4604:
4599:
4500:
4495:
4464:
4444:
4439:
4429:
4424:
4303:
4256:
4216:
3871:
3866:
3861:
3856:
3841:
3832:
3827:
3822:
3807:
3765:
3760:
3750:
3745:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3693:
3688:
3624:
3597:
3592:
3587:
3562:
3557:
3494:
3489:
3484:
3474:
3469:
3422:
3417:
3412:
3402:
3397:
3380:
3375:
3370:
3360:
3355:
3340:
3335:
3330:
3320:
3315:
3310:
3293:
3288:
3283:
3234:
3202:
3197:
3192:
3175:
3170:
3165:
3160:
1453:
that functions to blocks tumor metastasis. In addition to GAGs,
1212:
1169:
150:
5137:
3100:
3041:: STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES
2994:
590:
4629:
3241:
3229:
3224:
3219:
3209:
3182:
3150:
2990:
2282:
KΓΆhler S, Ullrich S, Richter U, Schumacher U (February 2010).
1426:
776:
positive regulation of phosphatidylinositol 3-kinase signaling
3086:: P-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH PSGL-1 PEPTIDE
786:
calcium-mediated signaling using intracellular calcium source
137:, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, selectin P
2969:
Overview of all the structural information available in the
2948:
Overview of all the structural information available in the
2605:
Lazo-Langner A, Goss GD, Spaans JN, Rodger MA (April 2007).
2198:
American
Journal of Respiratory Cell and Molecular Biology
1220:
and endothelial cells are activated by agonists such as
406:
2146:
Cleator JH, Zhu WQ, Vaughan DE, Hamm HE (April 2006).
571:
3056:: Crystal structure of P-selectin lectin/EGF domains
1187:. In unactivated endothelial cells, it is stored in
5614:
5582:
5507:
5479:
5426:
5400:
5391:
5382:
5295:
5184:
5175:
4935:
4729:
4478:
4162:
3885:
3545:
3143:
1195:. In unactivated platelets P-selectin is stored in
1075:
1050:
1024:
1003:
2756:Bajorath J, Stenkamp R, Aruffo A (November 1993).
2523:Garcia J, Callewaert N, Borsig L (February 2007).
1521:
1519:
1517:
1500:
1498:
1496:
2896:Archivum Immunologiae et Therapiae Experimentalis
2333:Archivum Immunologiae et Therapiae Experimentalis
353:
252:
2372:
2370:
1934:PanΓ©s J, Perry M, Granger DN (February 1999).
1526:GRCm38: Ensembl release 89: ENSMUSG00000026580
5149:
3112:
3006:
8:
1248:, respectively. In response to inflammatory
1224:, P-selectin is rapidly translocated to the
1505:GRCh38: Ensembl release 89: ENSG00000174175
1441:-dependent. One of the sulfated ligands is
771:defense response to Gram-negative bacterium
5397:
5388:
5181:
5156:
5142:
5134:
3119:
3105:
3097:
3013:
2999:
2991:
836:
791:positive regulation of platelet activation
751:positive regulation of leukocyte migration
606:
394:
293:
190:
76:
3136:list of human clusters of differentiation
2941:at the U.S. National Library of Medicine
2781:
2728:
2679:
2622:
2581:
2540:
2412:
2402:
2307:
2258:
2248:
2171:
2122:
1959:
1910:
1900:
1859:
1810:
1769:
1720:
1679:
1638:
3028:
1492:
1290:complement-binding protein-like domains
1703:Pan J, Xia L, McEver RP (April 1998).
31:
2801:Seminars in Thrombosis and Hemostasis
2611:Journal of Thrombosis and Haemostasis
1619:The Journal of Clinical Investigation
1396:that are still poorly characterized.
720:integral component of plasma membrane
358:
319:
314:
257:
216:
211:
7:
1889:The Journal of Experimental Medicine
510:endothelial cell of lymphatic vessel
2709:The New England Journal of Medicine
1799:The Journal of Biological Chemistry
1709:The Journal of Biological Chemistry
1179:(CAM) on the surfaces of activated
1072:
1047:
1021:
1000:
976:
957:
931:
912:
886:
867:
576:
494:
432:
411:
25:
1165:that in humans is encoded by the
761:regulation of integrin activation
639:calcium-dependent protein binding
3076:
3061:
3046:
3031:
2624:10.1111/j.1538-7836.2007.02427.x
1324:. PSGL-1 is situated on various
710:external side of plasma membrane
580:
342:
335:
329:
306:
241:
234:
228:
203:
40:
2482:International Journal of Cancer
1940:British Journal of Pharmacology
1360:) to the site of injury during
705:platelet dense granule membrane
700:platelet alpha granule membrane
1364:. When endothelial cells are
811:leukocyte tethering or rolling
801:response to lipopolysaccharide
690:integral component of membrane
591:More reference expression data
560:More reference expression data
460:olfactory zone of nasal mucosa
1:
2076:10.1152/physrev.1999.79.1.181
1812:10.1016/S0021-9258(18)83104-0
1750:Molecular Biology of the Cell
1580:Current Opinion in Immunology
327:
226:
2879:10.1016/j.molmed.2004.02.007
2867:Trends in Molecular Medicine
2850:10.1016/j.molmed.2004.02.008
2838:Trends in Molecular Medicine
1997:10.1016/j.neulet.2005.04.090
1592:10.1016/0952-7915(92)90120-4
1163:type-1 transmembrane protein
741:leukocyte cell-cell adhesion
27:Type-1 transmembrane protein
5695:Genes on human chromosome 1
3132:clusters of differentiation
2583:10.1182/blood.V70.2.551.551
2210:10.1165/ajrcmb.12.3.7532979
2103:The Journal of Cell Biology
1840:The Journal of Cell Biology
1388:P-selectin attaches to the
5721:
5622:Lymphocyte homing receptor
2983:(Mouse P-selectin) at the
2962:(Human P-selectin) at the
2164:10.1182/blood-2004-07-2698
1216:secretory granules. When
1175:P-selectin functions as a
634:lipopolysaccharide binding
3026:
2908:10.1007/s00005-006-0010-6
2438:Cancer Metastasis Reviews
2345:10.1007/s00005-006-0010-6
2288:British Journal of Cancer
2041:10.1182/blood.V95.10.3146
1561:"Mouse PubMed Reference:"
1543:"Human PubMed Reference:"
1145:
1140:
1136:
1129:
1113:
1107:Chr 1: 163.94 β 163.98 Mb
1100:Chr 1: 169.59 β 169.63 Mb
1094:
1079:
1054:
1043:
1028:
1007:
996:
983:
979:
964:
960:
951:
938:
934:
919:
915:
906:
893:
889:
874:
870:
861:
846:
839:
835:
819:
644:glycosphingolipid binding
609:
605:
588:
579:
570:
557:
506:
497:
444:
435:
405:
397:
393:
376:
363:
326:
305:
296:
292:
275:
262:
225:
202:
193:
189:
144:
141:
131:
124:
119:
84:
79:
62:
57:
52:
48:
39:
34:
5654:Carcinoembryonic antigen
5508:Unconventional/ungrouped
2943:Medical Subject Headings
2250:10.3389/fimmu.2013.00084
1722:10.1074/jbc.273.16.10058
1668:Human Molecular Genetics
5169:cell adhesion molecules
2237:Frontiers in Immunology
629:oligosaccharide binding
464:upper lobe of left lung
5700:Cell adhesion proteins
2774:10.1002/pro.5560021103
2404:10.1073/pnas.061615598
2300:10.1038/sj.bjc.6605492
2115:10.1083/jcb.142.5.1381
1952:10.1038/sj.bjp.0702328
1177:cell adhesion molecule
756:platelet degranulation
360:1 H2.2|1 71.42 cM
5361:Glycoprotein IIb/IIIa
2721:10.1056/NEJMoa1611770
2542:10.1093/glycob/cwl059
2064:Physiological Reviews
1852:10.1083/jcb.121.3.655
1392:cytoskeleton through
781:inflammatory response
448:right coronary artery
5333:Macrophage-1 antigen
5319:Integrin alphaXbeta2
2813:10.1055/s-2002-20564
1985:Neuroscience Letters
1902:10.1084/jem.20101545
1681:10.1093/hmg/7.8.1277
1280:-like domain in the
1242:Weibel-Palade bodies
1193:Weibel-Palade bodies
654:carbohydrate binding
476:left coronary artery
321:Chromosome 1 (mouse)
219:Chromosome 1 (human)
80:List of PDB id codes
53:Available structures
5198:Myelin protein zero
5177:Calcium-independent
2395:2001PNAS...98.3352B
1762:10.1091/mbc.3.3.309
1715:(16): 10058β10067.
1443:chondroitin sulfate
1326:hematopoietic cells
1207:Gene and regulation
796:leukocyte migration
715:extracellular space
669:calcium ion binding
659:sialic acid binding
480:canal of the cervix
2672:10.1593/neo.101734
2450:10.1007/BF00047657
941:ENSMUSG00000026580
734:Biological process
683:Cellular component
617:Molecular function
542:tibiofemoral joint
5682:
5681:
5610:
5609:
5578:
5577:
5384:Calcium-dependent
5378:
5377:
5165:Membrane proteins
5131:
5130:
3094:
3093:
2768:(11): 1798β1810.
2494:10.1002/ijc.22424
2035:(10): 3146β3152.
1895:(13): 2975β2987.
1805:(14): 7768β7771.
1631:10.1172/JCI114175
1447:glycosaminoglycan
1437:-independent and
1358:white blood cells
1296:contains six and
1156:
1155:
1152:
1151:
1125:
1124:
1090:
1089:
1069:
1068:
1039:
1038:
1018:
1017:
992:
991:
973:
972:
947:
946:
928:
927:
902:
901:
883:
882:
831:
830:
674:metal ion binding
601:
600:
597:
596:
566:
565:
553:
552:
491:
490:
456:left uterine tube
389:
388:
288:
287:
115:
114:
111:
110:
63:Ortholog search:
16:(Redirected from
5712:
5398:
5389:
5182:
5158:
5151:
5144:
5135:
3121:
3114:
3107:
3098:
3080:
3065:
3050:
3035:
3015:
3008:
3001:
2992:
2927:
2890:
2861:
2832:
2795:
2785:
2743:
2742:
2732:
2700:
2694:
2693:
2683:
2651:
2645:
2644:
2626:
2602:
2596:
2595:
2585:
2561:
2555:
2554:
2544:
2520:
2514:
2513:
2488:(6): 1179β1191.
2476:
2470:
2469:
2433:
2427:
2426:
2416:
2406:
2389:(6): 3352β3357.
2374:
2365:
2364:
2328:
2322:
2321:
2311:
2279:
2273:
2272:
2262:
2252:
2228:
2222:
2221:
2192:
2186:
2185:
2175:
2158:(7): 2736β2744.
2143:
2137:
2136:
2126:
2109:(5): 1381β1391.
2094:
2088:
2087:
2059:
2053:
2052:
2023:
2017:
2016:
1980:
1974:
1973:
1963:
1931:
1925:
1924:
1914:
1904:
1880:
1874:
1873:
1863:
1831:
1825:
1824:
1814:
1790:
1784:
1783:
1773:
1741:
1735:
1734:
1724:
1700:
1694:
1693:
1683:
1674:(8): 1277β1284.
1659:
1653:
1652:
1642:
1610:
1604:
1603:
1575:
1569:
1568:
1557:
1551:
1550:
1539:
1533:
1523:
1512:
1502:
1465:As a drug target
1260:, P-selectin is
1138:
1137:
1109:
1102:
1085:
1073:
1064:
1048:
1044:RefSeq (protein)
1034:
1022:
1013:
1001:
977:
958:
932:
913:
887:
868:
837:
607:
593:
584:
577:
562:
518:secondary oocyte
502:
500:Top expressed in
495:
440:
438:Top expressed in
433:
412:
395:
385:
372:
361:
346:
339:
333:
322:
310:
294:
284:
271:
260:
245:
238:
232:
221:
207:
191:
185:
183:SELP - orthologs
136:
129:
106:
77:
71:
50:
49:
44:
32:
21:
5720:
5719:
5715:
5714:
5713:
5711:
5710:
5709:
5685:
5684:
5683:
5678:
5606:
5574:
5503:
5475:
5422:
5374:
5291:
5171:
5162:
5132:
5127:
4931:
4725:
4474:
4158:
3881:
3541:
3139:
3125:
3095:
3090:
3087:
3081:
3072:
3066:
3057:
3051:
3042:
3036:
3022:
3019:
2935:
2930:
2893:
2864:
2835:
2798:
2762:Protein Science
2755:
2751:
2749:Further reading
2746:
2702:
2701:
2697:
2653:
2652:
2648:
2604:
2603:
2599:
2563:
2562:
2558:
2522:
2521:
2517:
2478:
2477:
2473:
2435:
2434:
2430:
2376:
2375:
2368:
2330:
2329:
2325:
2281:
2280:
2276:
2230:
2229:
2225:
2194:
2193:
2189:
2145:
2144:
2140:
2096:
2095:
2091:
2061:
2060:
2056:
2025:
2024:
2020:
1982:
1981:
1977:
1933:
1932:
1928:
1882:
1881:
1877:
1833:
1832:
1828:
1792:
1791:
1787:
1743:
1742:
1738:
1702:
1701:
1697:
1661:
1660:
1656:
1612:
1611:
1607:
1577:
1576:
1572:
1559:
1558:
1554:
1541:
1540:
1536:
1524:
1515:
1503:
1494:
1490:
1478:
1467:
1417:oligosaccharide
1402:
1394:anchor proteins
1350:
1318:heparan sulfate
1310:
1286:EGF-like domain
1266:plasma membrane
1238:
1226:plasma membrane
1209:
1147:View/Edit Mouse
1142:View/Edit Human
1105:
1098:
1095:Location (UCSC)
1081:
1060:
1056:
1030:
1009:
922:ENSG00000174175
815:
729:
725:plasma membrane
678:
664:protein binding
624:heparin binding
589:
558:
549:
544:
540:
536:
532:
528:
524:
520:
516:
512:
498:
487:
482:
478:
474:
470:
466:
462:
458:
454:
450:
436:
380:
367:
359:
349:
348:
347:
340:
320:
297:Gene location (
279:
266:
258:
248:
247:
246:
239:
217:
194:Gene location (
145:
132:
125:
86:
64:
28:
23:
22:
15:
12:
11:
5:
5718:
5716:
5708:
5707:
5702:
5697:
5687:
5686:
5680:
5679:
5677:
5676:
5671:
5666:
5661:
5656:
5650:
5649:
5633:
5628:
5618:
5616:
5612:
5611:
5608:
5607:
5605:
5604:
5599:
5594:
5588:
5586:
5580:
5579:
5576:
5575:
5573:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5511:
5509:
5505:
5504:
5502:
5501:
5496:
5491:
5485:
5483:
5477:
5476:
5474:
5473:
5455:
5432:
5430:
5424:
5423:
5421:
5420:
5415:
5410:
5404:
5402:
5395:
5386:
5380:
5379:
5376:
5375:
5373:
5372:
5358:
5344:
5330:
5316:
5301:
5299:
5293:
5292:
5290:
5289:
5288:
5287:
5282:
5277:
5272:
5267:
5262:
5252:
5251:
5250:
5245:
5240:
5235:
5225:
5220:
5215:
5201:
5190:
5188:
5179:
5173:
5172:
5163:
5161:
5160:
5153:
5146:
5138:
5129:
5128:
5126:
5125:
5120:
5115:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5075:
5070:
5065:
5060:
5055:
5050:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4939:
4937:
4933:
4932:
4930:
4929:
4924:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4733:
4731:
4727:
4726:
4724:
4723:
4718:
4709:
4704:
4699:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4663:
4662:
4657:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4576:
4567:
4562:
4561:
4560:
4555:
4545:
4540:
4539:
4538:
4533:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4482:
4480:
4476:
4475:
4473:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4386:
4385:
4380:
4370:
4365:
4360:
4355:
4354:
4353:
4348:
4343:
4333:
4328:
4323:
4318:
4313:
4312:
4311:
4306:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4265:
4264:
4259:
4249:
4243:
4238:
4233:
4228:
4219:
4214:
4213:
4212:
4207:
4202:
4192:
4187:
4182:
4177:
4172:
4166:
4164:
4160:
4159:
4157:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4030:
4029:
4024:
4014:
4013:
4012:
4007:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3936:
3935:
3930:
3920:
3915:
3910:
3905:
3900:
3895:
3889:
3887:
3883:
3882:
3880:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3830:
3825:
3820:
3815:
3810:
3805:
3804:
3803:
3798:
3793:
3788:
3783:
3778:
3768:
3763:
3758:
3753:
3748:
3743:
3742:
3741:
3736:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3685:
3684:
3679:
3674:
3669:
3664:
3659:
3649:
3648:
3647:
3642:
3637:
3627:
3622:
3621:
3620:
3615:
3610:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3549:
3547:
3543:
3542:
3540:
3539:
3534:
3533:
3532:
3527:
3522:
3517:
3512:
3507:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3466:
3465:
3460:
3455:
3450:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3394:
3393:
3388:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3307:
3306:
3301:
3291:
3286:
3281:
3276:
3275:
3274:
3269:
3264:
3259:
3249:
3244:
3239:
3238:
3237:
3227:
3222:
3217:
3212:
3207:
3206:
3205:
3200:
3195:
3185:
3180:
3179:
3178:
3173:
3168:
3163:
3158:
3147:
3145:
3141:
3140:
3126:
3124:
3123:
3116:
3109:
3101:
3092:
3091:
3089:
3088:
3082:
3075:
3073:
3067:
3060:
3058:
3052:
3045:
3043:
3037:
3030:
3027:
3024:
3023:
3020:
3018:
3017:
3010:
3003:
2995:
2989:
2988:
2967:
2946:
2934:
2933:External links
2931:
2929:
2928:
2891:
2873:(4): 179β186.
2862:
2844:(4): 171β178.
2833:
2796:
2752:
2750:
2747:
2745:
2744:
2715:(5): 429β439.
2695:
2666:(5): 445β452.
2646:
2617:(4): 729β737.
2597:
2576:(2): 551β557.
2556:
2535:(2): 185β196.
2515:
2471:
2428:
2366:
2323:
2294:(3): 602β609.
2274:
2223:
2204:(3): 315β319.
2187:
2138:
2089:
2070:(1): 181β213.
2054:
2018:
1991:(3): 305β309.
1975:
1946:(3): 537β550.
1926:
1875:
1846:(3): 655β664.
1826:
1785:
1756:(3): 309β321.
1736:
1695:
1654:
1605:
1570:
1552:
1534:
1513:
1491:
1489:
1486:
1485:
1484:
1477:
1474:
1466:
1463:
1429:breast cancer
1401:
1400:Role in cancer
1398:
1349:
1346:
1309:
1306:
1237:
1234:
1218:megakaryocytes
1208:
1205:
1154:
1153:
1150:
1149:
1144:
1134:
1133:
1127:
1126:
1123:
1122:
1120:
1118:
1111:
1110:
1103:
1096:
1092:
1091:
1088:
1087:
1077:
1076:
1070:
1067:
1066:
1052:
1051:
1045:
1041:
1040:
1037:
1036:
1026:
1025:
1019:
1016:
1015:
1005:
1004:
998:
994:
993:
990:
989:
981:
980:
974:
971:
970:
962:
961:
955:
949:
948:
945:
944:
936:
935:
929:
926:
925:
917:
916:
910:
904:
903:
900:
899:
891:
890:
884:
881:
880:
872:
871:
865:
859:
858:
853:
848:
844:
843:
833:
832:
829:
828:
817:
816:
814:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
737:
735:
731:
730:
728:
727:
722:
717:
712:
707:
702:
697:
692:
686:
684:
680:
679:
677:
676:
671:
666:
661:
656:
651:
649:fucose binding
646:
641:
636:
631:
626:
620:
618:
614:
613:
603:
602:
599:
598:
595:
594:
586:
585:
574:
568:
567:
564:
563:
555:
554:
551:
550:
548:
547:
543:
539:
535:
531:
527:
526:primary oocyte
523:
519:
515:
511:
507:
504:
503:
492:
489:
488:
486:
485:
481:
477:
473:
469:
468:gastric mucosa
465:
461:
457:
453:
449:
445:
442:
441:
429:
428:
420:
409:
403:
402:
399:RNA expression
391:
390:
387:
386:
378:
374:
373:
365:
362:
357:
351:
350:
341:
334:
328:
324:
323:
318:
312:
311:
303:
302:
290:
289:
286:
285:
277:
273:
272:
264:
261:
256:
250:
249:
240:
233:
227:
223:
222:
215:
209:
208:
200:
199:
187:
186:
143:
139:
138:
130:
122:
121:
117:
116:
113:
112:
109:
108:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5717:
5706:
5703:
5701:
5698:
5696:
5693:
5692:
5690:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5655:
5652:
5651:
5647:
5643:
5639:
5638:
5634:
5632:
5629:
5627:
5623:
5620:
5619:
5617:
5613:
5603:
5600:
5598:
5595:
5593:
5590:
5589:
5587:
5585:
5581:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5512:
5510:
5506:
5500:
5497:
5495:
5492:
5490:
5487:
5486:
5484:
5482:
5481:Protocadherin
5478:
5471:
5467:
5463:
5459:
5456:
5453:
5449:
5445:
5441:
5437:
5434:
5433:
5431:
5429:
5425:
5419:
5416:
5414:
5411:
5409:
5406:
5405:
5403:
5399:
5396:
5394:
5390:
5387:
5385:
5381:
5370:
5366:
5362:
5359:
5356:
5352:
5348:
5345:
5342:
5338:
5334:
5331:
5328:
5324:
5320:
5317:
5314:
5310:
5306:
5303:
5302:
5300:
5298:
5294:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5257:
5256:
5253:
5249:
5246:
5244:
5241:
5239:
5236:
5234:
5231:
5230:
5229:
5226:
5224:
5221:
5219:
5216:
5213:
5209:
5205:
5202:
5199:
5195:
5192:
5191:
5189:
5187:
5183:
5180:
5178:
5174:
5170:
5166:
5159:
5154:
5152:
5147:
5145:
5140:
5139:
5136:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5059:
5056:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4940:
4938:
4934:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4734:
4732:
4728:
4722:
4719:
4717:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4661:
4658:
4656:
4653:
4652:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4580:
4577:
4575:
4571:
4568:
4566:
4563:
4559:
4556:
4554:
4551:
4550:
4549:
4546:
4544:
4541:
4537:
4534:
4532:
4529:
4528:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4483:
4481:
4477:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4384:
4381:
4379:
4376:
4375:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4352:
4349:
4347:
4344:
4342:
4339:
4338:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4310:
4307:
4305:
4302:
4301:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4263:
4260:
4258:
4255:
4254:
4253:
4250:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4223:
4220:
4218:
4215:
4211:
4208:
4206:
4203:
4201:
4198:
4197:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4167:
4165:
4161:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4028:
4025:
4023:
4020:
4019:
4018:
4015:
4011:
4008:
4006:
4003:
4002:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3934:
3931:
3929:
3926:
3925:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3890:
3888:
3884:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3773:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3740:
3737:
3735:
3732:
3731:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3654:
3653:
3650:
3646:
3643:
3641:
3638:
3636:
3633:
3632:
3631:
3628:
3626:
3623:
3619:
3616:
3614:
3611:
3609:
3606:
3605:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3550:
3548:
3544:
3538:
3535:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3502:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3445:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3392:
3389:
3387:
3384:
3383:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3305:
3302:
3300:
3297:
3296:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3254:
3253:
3250:
3248:
3245:
3243:
3240:
3236:
3233:
3232:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3204:
3201:
3199:
3196:
3194:
3191:
3190:
3189:
3186:
3184:
3181:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3153:
3152:
3149:
3148:
3146:
3142:
3137:
3133:
3129:
3122:
3117:
3115:
3110:
3108:
3103:
3102:
3099:
3085:
3079:
3074:
3070:
3064:
3059:
3055:
3049:
3044:
3040:
3034:
3029:
3025:
3016:
3011:
3009:
3004:
3002:
2997:
2996:
2993:
2986:
2982:
2981:
2976:
2972:
2968:
2965:
2961:
2960:
2955:
2951:
2947:
2944:
2940:
2937:
2936:
2932:
2925:
2921:
2917:
2913:
2909:
2905:
2901:
2897:
2892:
2888:
2884:
2880:
2876:
2872:
2868:
2863:
2859:
2855:
2851:
2847:
2843:
2839:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2797:
2793:
2789:
2784:
2779:
2775:
2771:
2767:
2763:
2759:
2754:
2753:
2748:
2740:
2736:
2731:
2726:
2722:
2718:
2714:
2710:
2706:
2699:
2696:
2691:
2687:
2682:
2677:
2673:
2669:
2665:
2661:
2657:
2650:
2647:
2642:
2638:
2634:
2630:
2625:
2620:
2616:
2612:
2608:
2601:
2598:
2593:
2589:
2584:
2579:
2575:
2571:
2567:
2560:
2557:
2552:
2548:
2543:
2538:
2534:
2530:
2526:
2519:
2516:
2511:
2507:
2503:
2499:
2495:
2491:
2487:
2483:
2475:
2472:
2467:
2463:
2459:
2455:
2451:
2447:
2444:(2): 99β114.
2443:
2439:
2432:
2429:
2424:
2420:
2415:
2410:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2373:
2371:
2367:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2334:
2327:
2324:
2319:
2315:
2310:
2305:
2301:
2297:
2293:
2289:
2285:
2278:
2275:
2270:
2266:
2261:
2256:
2251:
2246:
2242:
2238:
2234:
2227:
2224:
2219:
2215:
2211:
2207:
2203:
2199:
2191:
2188:
2183:
2179:
2174:
2169:
2165:
2161:
2157:
2153:
2149:
2142:
2139:
2134:
2130:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2093:
2090:
2085:
2081:
2077:
2073:
2069:
2065:
2058:
2055:
2050:
2046:
2042:
2038:
2034:
2030:
2022:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1986:
1979:
1976:
1971:
1967:
1962:
1957:
1953:
1949:
1945:
1941:
1937:
1930:
1927:
1922:
1918:
1913:
1908:
1903:
1898:
1894:
1890:
1886:
1879:
1876:
1871:
1867:
1862:
1857:
1853:
1849:
1845:
1841:
1837:
1830:
1827:
1822:
1818:
1813:
1808:
1804:
1800:
1796:
1789:
1786:
1781:
1777:
1772:
1767:
1763:
1759:
1755:
1751:
1747:
1740:
1737:
1732:
1728:
1723:
1718:
1714:
1710:
1706:
1699:
1696:
1691:
1687:
1682:
1677:
1673:
1669:
1665:
1658:
1655:
1650:
1646:
1641:
1636:
1632:
1628:
1624:
1620:
1616:
1609:
1606:
1601:
1597:
1593:
1589:
1585:
1581:
1574:
1571:
1566:
1562:
1556:
1553:
1548:
1544:
1538:
1535:
1531:
1527:
1522:
1520:
1518:
1514:
1510:
1506:
1501:
1499:
1497:
1493:
1487:
1483:
1480:
1479:
1475:
1473:
1471:
1470:Crizanlizumab
1464:
1462:
1458:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1428:
1424:
1421:
1418:
1413:
1411:
1407:
1399:
1397:
1395:
1391:
1386:
1382:
1380:
1375:
1373:
1369:
1367:
1363:
1359:
1355:
1347:
1345:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1307:
1305:
1304:tail region.
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1278:C-type lectin
1275:
1274:extracellular
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1235:
1233:
1231:
1227:
1223:
1219:
1214:
1206:
1204:
1200:
1198:
1194:
1190:
1186:
1182:
1178:
1173:
1171:
1168:
1164:
1160:
1148:
1143:
1139:
1135:
1132:
1128:
1121:
1119:
1116:
1112:
1108:
1104:
1101:
1097:
1093:
1086:
1084:
1078:
1074:
1071:
1065:
1063:
1059:
1053:
1049:
1046:
1042:
1035:
1033:
1027:
1023:
1020:
1014:
1012:
1006:
1002:
999:
997:RefSeq (mRNA)
995:
988:
987:
982:
978:
975:
969:
968:
963:
959:
956:
954:
950:
943:
942:
937:
933:
930:
924:
923:
918:
914:
911:
909:
905:
898:
897:
892:
888:
885:
879:
878:
873:
869:
866:
864:
860:
857:
854:
852:
849:
845:
842:
838:
834:
827:
823:
818:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
766:cell adhesion
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
738:
736:
733:
732:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
687:
685:
682:
681:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
612:
611:Gene ontology
608:
604:
592:
587:
583:
578:
575:
573:
569:
561:
556:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
508:
505:
501:
496:
493:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
446:
443:
439:
434:
431:
430:
427:
425:
421:
419:
418:
414:
413:
410:
408:
404:
400:
396:
392:
384:
379:
375:
371:
366:
356:
352:
345:
338:
332:
325:
317:
313:
309:
304:
300:
295:
291:
283:
278:
274:
270:
265:
255:
251:
244:
237:
231:
224:
220:
214:
210:
206:
201:
197:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
140:
135:
128:
123:
118:
107:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
5635:
5601:
4649:
4569:
4547:
4525:
4372:
4335:
4298:
4251:
4221:
4194:
4016:
3922:
3770:
3617:
3499:
3251:
3083:
3068:
3053:
3038:
2978:
2957:
2902:(2): 75β84.
2899:
2895:
2870:
2866:
2841:
2837:
2807:(1): 53β66.
2804:
2800:
2765:
2761:
2712:
2708:
2698:
2663:
2659:
2649:
2614:
2610:
2600:
2573:
2569:
2559:
2532:
2529:Glycobiology
2528:
2518:
2485:
2481:
2474:
2441:
2437:
2431:
2386:
2382:
2339:(2): 75β84.
2336:
2332:
2326:
2291:
2287:
2277:
2240:
2236:
2226:
2201:
2197:
2190:
2155:
2151:
2141:
2106:
2102:
2092:
2067:
2063:
2057:
2032:
2028:
2021:
1988:
1984:
1978:
1943:
1939:
1929:
1892:
1888:
1878:
1843:
1839:
1829:
1802:
1798:
1788:
1753:
1749:
1739:
1712:
1708:
1698:
1671:
1667:
1657:
1625:(1): 92β99.
1622:
1618:
1608:
1586:(1): 33β37.
1583:
1579:
1573:
1564:
1555:
1546:
1537:
1468:
1459:
1445:, a type of
1414:
1403:
1387:
1383:
1376:
1370:
1362:inflammation
1351:
1311:
1262:translocated
1239:
1210:
1201:
1174:
1166:
1158:
1157:
1080:
1055:
1029:
1008:
984:
965:
939:
920:
894:
875:
855:
850:
422:
415:
381:163,977,595
368:163,942,833
280:169,630,193
267:169,588,849
142:External IDs
85:
29:
5458:Desmocollin
3021:PDB gallery
1338:lymphocytes
1334:eosinophils
1330:neutrophils
1302:cytoplasmic
1272:cells. The
1270:endothelial
1181:endothelial
1062:NP_002996.2
538:ankle joint
522:granulocyte
472:gallbladder
120:Identifiers
5689:Categories
5631:L-selectin
5602:P-selectin
5597:L-selectin
5592:E-selectin
5515:T-cadherin
5436:Desmoglein
5428:Desmosomal
3134:(see also
2939:P-Selectin
1532:, May 2017
1511:, May 2017
1488:References
1420:sialylated
1406:E-selectin
1354:leukocytes
1298:L-selectin
1294:E-selectin
1282:N-terminus
1246:Ξ±-granules
1197:Ξ±-granules
1159:P-selectin
426:(ortholog)
163:HomoloGene
5705:Selectins
5584:Selectins
5401:Classical
5393:Cadherins
5297:Integrins
5228:L1 family
2660:Neoplasia
1439:sulfation
1431:cell line
1410:platelets
1366:activated
1342:monocytes
1322:fucoidans
1250:cytokines
1236:Structure
1185:platelets
1083:NP_035477
1058:NP_002996
1032:NM_011347
1011:NM_003005
841:Orthologs
171:GeneCards
5637:integrin
5186:IgSF CAM
3128:Proteins
2924:33274938
2916:16648968
2887:15059609
2858:15059608
2821:11885026
2739:27959701
2690:21532885
2633:17408406
2551:17043066
2510:39853960
2502:17154173
2466:20508207
2423:11248082
2361:33274938
2353:16648968
2318:20010946
2269:23579783
2182:16332977
2049:10807781
2013:22979258
2005:15916851
1970:10188959
1921:21149548
1528:–
1507:–
1482:Selectin
1476:See also
1379:protease
1372:Thrombin
1348:Function
1328:such as
1252:such as
1230:granules
1222:thrombin
1189:granules
1131:Wikidata
820:Sources:
695:membrane
484:appendix
452:monocyte
4936:301β350
4730:251β300
4682:CD240CE
4479:201β250
4163:151β200
3886:101β150
2985:PDBe-KB
2975:UniProt
2964:PDBe-KB
2954:UniProt
2829:3222756
2792:7505680
2783:2142283
2730:5481200
2681:3084621
2641:7632947
2592:2955820
2458:6386144
2391:Bibcode
2309:2822933
2260:3619129
2218:7532979
2173:1895372
2133:9732297
2124:2149355
2084:9922371
1961:1565837
1912:3005233
1870:7683689
1861:2119562
1821:2470733
1780:1378326
1731:9545353
1690:9668170
1649:2472431
1600:1375831
1530:Ensembl
1509:Ensembl
1451:heparin
1423:Lewis x
1264:to the
1191:called
953:UniProt
908:Ensembl
847:Species
826:QuickGO
401:pattern
127:Aliases
5499:PCDH19
5494:PCDH15
5365:ITGA2B
5255:Nectin
5233:L1-CAM
5223:PE-CAM
5218:VCAM-1
4943:CD300A
4902:CDw293
4687:CD240D
4548:CD213a
4526:CDw210
4491:CD202b
4465:CDw199
4460:CDw198
4114:CD140b
3546:51β100
2980:Q01102
2959:P16109
2945:(MeSH)
2922:
2914:
2885:
2856:
2827:
2819:
2790:
2780:
2737:
2727:
2688:
2678:
2639:
2631:
2590:
2549:
2508:
2500:
2464:
2456:
2421:
2411:
2359:
2351:
2316:
2306:
2267:
2257:
2243:: 84.
2216:
2180:
2170:
2131:
2121:
2082:
2047:
2011:
2003:
1968:
1958:
1919:
1909:
1868:
1858:
1819:
1778:
1771:275532
1768:
1729:
1688:
1647:
1640:303957
1637:
1598:
1340:, and
1314:PSGL-1
1308:Ligand
1288:and a
1117:search
1115:PubMed
986:Q01102
967:P16109
863:Entrez
572:BioGPS
534:embryo
514:zygote
259:1q24.2
151:173610
5674:EpCAM
5669:CD146
5646:LFA-1
5642:VLA-4
5615:Other
5570:CDH10
5560:CDH17
5555:CDH16
5550:CDH15
5545:CDH12
5540:CDH11
5489:PCDH1
5369:ITGB3
5351:CD49d
5347:VLA-4
5337:CD11b
5323:CD11c
5309:CD11a
5305:LFA-1
5285:CD155
5280:CADM3
5275:CADM1
5270:PVRL3
5265:PVRL2
5260:PVRL1
5243:NFASC
5238:NRCAM
5194:N-CAM
5123:CD350
5118:CD349
5113:CD344
5108:CD340
5103:CD339
5098:CD338
5093:CD337
5088:CD336
5083:CD335
5078:CD334
5073:CD333
5068:CD332
5063:CD331
5058:CD329
5053:CD328
5048:CD327
5043:CD326
5038:CD325
5033:CD324
5028:CD322
5023:CD321
5018:CD320
5013:CD318
5008:CD317
5003:CD316
4998:CD315
4993:CD314
4988:CD312
4983:CD309
4978:CD307
4973:CD306
4968:CD305
4963:CD304
4958:CD303
4953:CD302
4948:CD301
4927:CD299
4922:CD298
4917:CD297
4912:CD295
4907:CD294
4897:CD292
4892:CD290
4887:CD289
4882:CD288
4877:CD286
4872:CD284
4867:CD283
4862:CD282
4857:CD281
4852:CD280
4847:CD279
4842:CD278
4837:CD276
4832:CD275
4827:CD274
4822:CD273
4817:CD272
4812:CD271
4807:CD269
4802:CD268
4797:CD267
4792:CD266
4787:CD265
4782:CD264
4777:CD263
4772:CD262
4767:CD261
4762:CD258
4757:CD257
4752:CD256
4747:CD254
4742:CD253
4737:CD252
4721:CD249
4716:CD248
4712:CD247
4707:CD246
4702:CD244
4697:CD243
4692:CD241
4677:CD239
4672:CD238
4667:CD236
4650:CD235
4645:CD234
4640:CD233
4635:CD230
4630:CD229
4625:CD228
4620:CD227
4615:CD226
4610:CD225
4605:CD224
4600:CD223
4595:CD222
4590:CD221
4585:CD220
4570:CD218
4565:CD217
4543:CD212
4521:CD209
4516:CD208
4511:CD207
4506:CD206
4501:CD205
4496:CD204
4486:CD201
4470:CD200
4455:CD197
4450:CD196
4445:CD195
4440:CD194
4435:CD193
4430:CD192
4425:CD191
4420:CD186
4415:CD185
4410:CD184
4405:CD183
4400:CD182
4395:CD181
4390:CD180
4373:CD179
4368:CD178
4363:CD177
4358:CD174
4336:CD172
4331:CD171
4326:CD170
4321:CD169
4316:CD168
4299:CD167
4294:CD166
4289:CD164
4284:CD163
4279:CD162
4274:CD161
4269:CD160
4252:CD159
4222:CD158
4217:CD157
4195:CD156
4190:CD155
4185:CD154
4180:CD153
4175:CD152
4170:CD151
4154:CD150
4149:CD148
4144:CD147
4139:CD146
4134:CD144
4129:CD143
4124:CD142
4119:CD141
4109:CD138
4104:CD137
4099:CD136
4094:CD135
4089:CD134
4084:CD133
4079:CD132
4074:CD131
4069:CD130
4064:CD129
4059:CD127
4054:CD126
4049:CD125
4044:CD124
4039:CD123
4034:CD122
4017:CD121
4000:CD120
3995:CD119
3990:CD118
3985:CD117
3980:CD116
3975:CD115
3970:CD114
3965:CD113
3960:CD112
3955:CD111
3950:CD110
3945:CD109
3940:CD108
3923:CD107
3918:CD106
3913:CD105
3908:CD104
3903:CD103
3898:CD102
3893:CD101
3877:CD100
2920:S2CID
2825:S2CID
2637:S2CID
2570:Blood
2506:S2CID
2462:S2CID
2414:30657
2357:S2CID
2152:Blood
2029:Blood
2009:S2CID
1455:mucin
1390:actin
1284:, an
1258:IL-13
1228:from
1213:exons
1161:is a
896:20344
856:Mouse
851:Human
822:Amigo
546:ankle
530:blood
424:Mouse
417:Human
364:Start
299:Mouse
263:Start
196:Human
159:98280
18:CD62P
5664:CD44
5659:CD24
5626:CD44
5565:CDH9
5535:CDH8
5530:CDH6
5525:CDH5
5520:CDH4
5470:DSC3
5466:DSC2
5462:DSC1
5452:DSG4
5448:DSG3
5444:DSG2
5440:DSG1
5418:CDH3
5413:CDH2
5408:CDH1
5355:CD29
5341:CD18
5327:CD18
5313:CD18
5248:CHL1
5204:ICAM
3872:CD99
3867:CD98
3862:CD97
3857:CD96
3852:CD95
3847:CD94
3842:CD93
3837:CD92
3833:CD91
3828:CD90
3823:CD89
3818:CD88
3813:CD87
3808:CD86
3771:CD85
3766:CD84
3761:CD83
3756:CD82
3751:CD81
3746:CD80
3729:CD79
3724:CD78
3719:CD74
3714:CD73
3709:CD72
3704:CD71
3699:CD70
3694:CD69
3689:CD68
3652:CD66
3630:CD64
3625:CD63
3603:CD62
3598:CD61
3593:CD59
3588:CD58
3583:CD57
3578:CD56
3573:CD55
3568:CD54
3563:CD53
3558:CD52
3553:CD51
3537:CD50
3500:CD49
3495:CD48
3490:CD47
3485:CD46
3480:CD45
3475:CD44
3470:CD43
3443:CD42
3438:CD41
3433:CD40
3428:CD39
3423:CD38
3418:CD37
3413:CD36
3408:CD35
3403:CD34
3398:CD33
3381:CD32
3376:CD31
3371:CD30
3366:CD29
3361:CD28
3356:CD27
3351:CD26
3346:CD25
3341:CD24
3336:CD23
3331:CD22
3326:CD21
3321:CD20
3316:CD19
3311:CD18
3294:CD16
3289:CD15
3284:CD14
3279:CD13
3252:CD11
3247:CD10
3144:1β50
3084:1g1s
3069:1g1r
3054:1g1q
3039:1fsb
2973:for
2952:for
2912:PMID
2883:PMID
2854:PMID
2817:PMID
2788:PMID
2735:PMID
2686:PMID
2629:PMID
2588:PMID
2547:PMID
2498:PMID
2454:PMID
2419:PMID
2349:PMID
2314:PMID
2265:PMID
2214:PMID
2178:PMID
2129:PMID
2080:PMID
2045:PMID
2001:PMID
1966:PMID
1917:PMID
1866:PMID
1817:PMID
1776:PMID
1727:PMID
1686:PMID
1645:PMID
1596:PMID
1415:The
1320:and
1256:and
1254:IL-4
1244:and
1170:gene
1167:SELP
877:6403
407:Bgee
355:Band
316:Chr.
254:Band
213:Chr.
175:SELP
167:2260
147:OMIM
134:SELP
104:1HES
100:1G1S
96:1G1R
92:1G1Q
88:1FSB
69:RCSB
66:PDBe
35:SELP
3242:CD9
3230:CD8
3225:CD7
3220:CD6
3215:CD5
3210:CD4
3188:CD3
3183:CD2
3156:a-c
3151:CD1
2971:PDB
2950:PDB
2904:doi
2875:doi
2846:doi
2809:doi
2778:PMC
2770:doi
2725:PMC
2717:doi
2713:376
2676:PMC
2668:doi
2619:doi
2578:doi
2537:doi
2490:doi
2486:120
2446:doi
2409:PMC
2399:doi
2341:doi
2304:PMC
2296:doi
2292:102
2255:PMC
2245:doi
2206:doi
2168:PMC
2160:doi
2156:107
2119:PMC
2111:doi
2107:142
2072:doi
2037:doi
1993:doi
1989:384
1956:PMC
1948:doi
1944:126
1907:PMC
1897:doi
1893:207
1856:PMC
1848:doi
1844:121
1807:doi
1803:264
1766:PMC
1758:doi
1717:doi
1713:273
1676:doi
1635:PMC
1627:doi
1588:doi
1427:4T1
1268:in
377:End
276:End
179:OMA
155:MGI
59:PDB
5691::
5644:,
5624::
5468:,
5464:,
5450:,
5446:,
5442:,
5210:,
5167::
4714:-
3835:-
3176:1E
3171:1D
3166:1B
3161:1A
3130::
2977::
2956::
2918:.
2910:.
2900:54
2898:.
2881:.
2871:10
2869:.
2852:.
2842:10
2840:.
2823:.
2815:.
2805:28
2803:.
2786:.
2776:.
2764:.
2760:.
2733:.
2723:.
2711:.
2707:.
2684:.
2674:.
2664:13
2662:.
2658:.
2635:.
2627:.
2613:.
2609:.
2586:.
2574:70
2572:.
2568:.
2545:.
2533:17
2531:.
2527:.
2504:.
2496:.
2484:.
2460:.
2452:.
2440:.
2417:.
2407:.
2397:.
2387:98
2385:.
2381:.
2369:^
2355:.
2347:.
2337:54
2335:.
2312:.
2302:.
2290:.
2286:.
2263:.
2253:.
2239:.
2235:.
2212:.
2202:12
2200:.
2176:.
2166:.
2154:.
2150:.
2127:.
2117:.
2105:.
2101:.
2078:.
2068:79
2066:.
2043:.
2033:95
2031:.
2007:.
1999:.
1987:.
1964:.
1954:.
1942:.
1938:.
1915:.
1905:.
1891:.
1887:.
1864:.
1854:.
1842:.
1838:.
1815:.
1801:.
1797:.
1774:.
1764:.
1752:.
1748:.
1725:.
1711:.
1707:.
1684:.
1670:.
1666:.
1643:.
1633:.
1623:84
1621:.
1617:.
1594:.
1582:.
1563:.
1545:.
1516:^
1495:^
1435:Ca
1336:,
1332:,
1199:.
1172:.
824:/
383:bp
370:bp
282:bp
269:bp
177:;
173::
169:;
165::
161:;
157::
153:;
149::
102:,
98:,
94:,
90:,
5648:)
5640:(
5472:)
5460:(
5454:)
5438:(
5371:)
5367:+
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