1695:
346:
323:
220:
245:
3507:
3537:
597:
352:
251:
3522:
29:
1615:
in a cohort of 17 healthy human volunteers. This experimental vaccine was well-tolerated, and those who received the adjuvanted vaccine had stronger anti-HCV immune responses (enhanced magnitude, breadth and proliferative capacity of anti-HCV-specific T-cells) compared with volunteers who received
55:
1702:
CD74 receptor is expressed on the surface of different cell types. Interaction between MIF cytokine and its cell membrane receptor CD74 activates pro-survival and proliferative pathways that protect against injury and promote healing in different parts of the body.
2479:"The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors"
1574:
interacts with MHC II, releasing CLIP and allowing other peptides to bind. In some cases, CLIP dissociates without any further molecular interactions, but in other cases the binding to the MHC is more stable.
1545:
The invariant chain also facilitates the export of MHC class II from the RER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late
3322:
Naujokas MF, Morin M, Anderson MS, Peterson M, Miller J (July 1993). "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44".
4438:
2385:
Wang F, Shen X, Guo X, Peng Y, Liu Y, Xu S, Yang J (February 2010). "Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats".
2699:
Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P (December 1992). "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides".
3277:
Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC (July 1993). "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1".
3577:
3506:
359:
258:
4428:
2956:"Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes"
1550:
containing the endocytosed antigen proteins (from the exogenous pathway). Binding to Ii ensures that no antigen peptides from the endogenous pathway meant for
2309:"Targeting Parasite-Produced Macrophage Migration Inhibitory Factor as an Antivirulence Strategy With Antibiotic-Antibody Combination to Reduce Tissue Damage"
1542:(RER) binds a segment of the invariant chain (Ii; a trimer) in order to shape the peptide-binding groove and prevent the formation of a closed conformation.
4408:
3536:
2264:
Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, et al. (June 2014). "Autoantibodies against CD74 in spondyloarthritis".
1165:
181:
5270:
3594:
3570:
2630:
Jones PP, Murphy DB, Hewgill D, McDevitt HO (January 1979). "Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates".
1582:
on the cell surface. Without CLIP, MHC class II aggregates disassemble and/or denature in the endosomes, and proper antigen presentation is impaired.
1146:
1659:
2238:
5001:
4989:
4767:
3036:
Claesson L, Peterson PA (June 1983). "Association of human gamma chain with class II transplantation antigens during intracellular transport".
1683:
1523:
5053:
5048:
4994:
4774:
3555:
3486:
3189:
Ghosh P, Amaya M, Mellins E, Wiley DC (November 1995). "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3".
3109:
2072:
1822:
5607:
5602:
4507:
4433:
3563:
1804:
1663:
3067:"The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity"
2745:
345:
52:
5536:
5531:
5526:
5521:
4448:
1842:"cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure"
1405:
3446:
2876:"Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation"
2790:"Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens"
1412:
322:
5501:
3521:
3152:
Machamer CE, Cresswell P (December 1982). "Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens".
1694:
2917:
Genuardi M, Saunders GF (1988). "Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32".
4737:
1724:
1563:
1535:
5305:
4799:
4485:
1791:
1770:
4944:
4480:
1787:
3429:
1570:
remaining bound to the groove of MHC class II molecules. The rest of the Ii is degraded. CLIP blocks peptide-binding until
244:
219:
5441:
4913:
4908:
4853:
4587:
4036:
3452:
1766:
5135:
4858:
3007:
Koch N, HΓ€mmerling GJ (October 1985). "Ia-associated invariant chain is fatty acylated before addition of sialic acid".
161:
4453:
1679:
2430:"The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei"
358:
257:
5165:
3590:
1736:
4031:
3479:
351:
250:
5215:
4110:
3423:
1210:
169:
5179:
1655:
1191:
1026:
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
2145:
Vogt AB, Kropshofer H (April 1999). "HLA-DM - an endosomal and lysosomal chaperone for the immune system".
5612:
4522:
4517:
4512:
4502:
3809:
3737:
1667:
3439:
3866:
3784:
1901:"Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens"
1539:
1519:
5103:
4816:
3472:
3372:
3286:
3198:
2967:
2708:
2182:"MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans"
1853:
1579:
1507:
233:
2428:
Dobson SE, Augustijn KD, Brannigan JA, Schnick C, Janse CJ, Dodson EJ, et al. (December 2009).
148:
5130:
4949:
3458:
2098:"The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway"
1612:
1384:
1363:
1359:
1351:
1347:
1317:
1296:
1292:
1288:
1284:
3361:"Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization"
1711:
The invariant chain was first described by
Patricia P. Jones, Donal B. Murphy, Derek Hewgill, and
4537:
4271:
3419:
3347:
3310:
3222:
3177:
3140:
2942:
2862:
2776:
2732:
2410:
2289:
2219:
1651:
1600:
193:
1388:
1355:
1321:
1280:
1554:
molecules accidentally bind to the groove of MHC class II molecules. The Ii is then cleaved by
3400:
3339:
3302:
3265:
3214:
3169:
3132:
3096:
3053:
3024:
2995:
2934:
2905:
2854:
2819:
2768:
2746:"MHC class II-associated invariant chain contains a sorting signal for endosomal compartments"
2724:
2687:
2647:
2612:
2581:"Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair"
2561:
2510:
2459:
2402:
2367:
2340:
2281:
2211:
2162:
2127:
2078:
2068:
2042:
2011:"Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair"
1991:
1930:
1881:
1604:
141:
45:
3236:"Mapping functional regions in the lumenal domain of the class II-associated invariant chain"
2180:
Esposito I, Cicconi P, D'Alise AM, Brown A, Esposito M, Swadling L, et al. (June 2020).
5310:
5043:
4964:
4527:
3720:
3646:
3433:
3390:
3380:
3331:
3294:
3255:
3247:
3206:
3161:
3124:
3086:
3078:
3045:
3016:
2985:
2975:
2926:
2895:
2887:
2844:
2809:
2801:
2760:
2716:
2679:
2639:
2602:
2592:
2551:
2541:
2500:
2490:
2449:
2441:
2394:
2330:
2320:
2273:
2201:
2193:
2154:
2117:
2109:
2032:
2022:
1983:
1920:
1912:
1871:
1861:
1620:
438:
369:
313:
268:
5370:
3906:
3901:
3824:
3515:: CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L
2307:
Ghosh S, Padalia J, Ngobeni R, Abendroth J, Farr L, Shirley DA, et al. (March 2020).
596:
413:
189:
3376:
3290:
3202:
2971:
2712:
1987:
1857:
5155:
4577:
4088:
3891:
3260:
3235:
3082:
2900:
2875:
2814:
2789:
2607:
2580:
2556:
2529:
2528:
Verjans E, Noetzel E, Bektas N, SchΓΌtz AK, Lue H, Lennartz B, et al. (July 2009).
2505:
2478:
2454:
2429:
2335:
2308:
2206:
2181:
2122:
2097:
2037:
2010:
1643:
1623:, if this enhancing effect can be demonstrated to apply to the appropriate antigen(s).
1567:
3091:
3066:
2990:
2955:
2358:
Shan ZX, Lin QX, Deng CY, Tan HH, Kuang SJ, Xiao DZ, et al. (December 2009). "".
2158:
1925:
1900:
1876:
1841:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
28:
5596:
5125:
4582:
3673:
3395:
3360:
3335:
3128:
2764:
2643:
2223:
1712:
1515:
931:
negative regulation of DNA damage response, signal transduction by p53 class mediator
625:
3351:
3181:
2780:
2414:
2293:
2277:
1518:
responses. The cell surface form of the invariant chain is known as CD74. CD74 is a
5481:
4789:
4779:
4310:
4276:
3314:
3226:
3144:
2946:
2866:
2736:
1974:
Cresswell P (1994). "Assembly, transport, and function of MHC class II molecules".
1596:
1559:
1511:
431:
210:
3110:"Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens"
2530:"Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer"
173:
2197:
901:
antigen processing and presentation of exogenous peptide antigen via MHC class II
197:
5491:
5140:
4918:
4893:
4592:
4214:
4140:
3614:
3165:
2849:
2832:
2239:"Adjuvanted viral-vectored vaccine promising against hepatitis C in early trial"
1827:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1809:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1741:
1632:
1555:
1551:
3365:
Proceedings of the
National Academy of Sciences of the United States of America
2960:
Proceedings of the
National Academy of Sciences of the United States of America
2683:
2398:
1846:
Proceedings of the
National Academy of Sciences of the United States of America
514:
5421:
5145:
4826:
4567:
4443:
4076:
4071:
4066:
3921:
3705:
2113:
1647:
330:
227:
177:
2597:
2082:
2027:
1916:
5260:
5255:
5250:
5240:
5235:
5230:
5225:
3385:
2980:
2954:
O'Sullivan DM, Larhammar D, Wilson MC, Peterson PA, Quaranta V (June 1986).
2670:
Stove V, Verhasselt B (January 2006). "Modelling thymic HIV-1 Nef effects".
2546:
2495:
2325:
1866:
1631:
Found on a number of cancer cell types. Possible cancer therapy target. See
1110:
574:
452:
397:
384:
296:
283:
185:
2691:
2616:
2565:
2514:
2477:
Piette C, Deprez M, Roger T, NoΓ«l A, Foidart JM, Munaut C (November 2009).
2463:
2406:
2371:
2344:
2285:
2215:
2166:
2131:
2046:
3404:
3343:
3306:
3269:
3251:
3218:
3173:
3136:
3100:
3057:
3028:
2999:
2938:
2909:
2891:
2858:
2823:
2805:
2772:
2728:
1995:
1934:
1885:
1619:
The Ii molecule might also prove to be useful as an adjuvant for a future
1452:
1447:
5566:
5466:
5280:
5265:
4468:
4463:
4371:
4061:
2651:
1948:
1715:
at
Stanford. The nomenclature "Ii" comes from an Ix-based naming system (
1608:
1547:
1436:
1255:
1236:
896:
positive regulation of dendritic cell antigen processing and presentation
3049:
3020:
5516:
5511:
5506:
5406:
5220:
5210:
5037:
5016:
5011:
4979:
4784:
4704:
4699:
4694:
4689:
4684:
4602:
4295:
4135:
4130:
4125:
4120:
4115:
3586:
2930:
2833:"The invariant chain is a phosphorylated subunit of class II molecules"
1503:
1484:
1222:
1177:
2360:
Nan Fang Yi Ke da Xue Xue Bao = Journal of
Southern Medical University
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
5456:
5416:
5401:
5385:
5380:
5360:
5355:
5290:
5098:
5068:
5032:
5023:
4836:
4804:
4668:
4663:
4633:
4612:
4572:
4532:
4398:
4376:
4335:
4259:
4254:
4249:
4244:
4239:
4234:
4103:
4098:
4093:
4041:
4026:
3896:
3886:
3849:
3844:
3762:
3757:
3298:
3210:
3108:
Kvist S, Wiman K, Claesson L, Peterson PA, Dobberstein B (May 1982).
2720:
1571:
1420:
1132:
2445:
795:
integral component of lumenal side of endoplasmic reticulum membrane
3359:
Roche PA, Teletski CL, Stang E, Bakke O, Long EO (September 1993).
5581:
5556:
5476:
5471:
5461:
5451:
5436:
5431:
5426:
5411:
5365:
5350:
5315:
5300:
5295:
5285:
5205:
5200:
5195:
5174:
5170:
5160:
5073:
4974:
4969:
4928:
4878:
4873:
4868:
4863:
4848:
4841:
4821:
4809:
4752:
4747:
4742:
4732:
4727:
4720:
4658:
4648:
4643:
4638:
4628:
4607:
4597:
4562:
4557:
4552:
4547:
4542:
4497:
4492:
4458:
4423:
4418:
4413:
4403:
4391:
4386:
4366:
4361:
4356:
4351:
4305:
4197:
4192:
4011:
3995:
3988:
3983:
3978:
3973:
3968:
3963:
3938:
3916:
3911:
3804:
3730:
3725:
3715:
3545:: NMR structure of P41icf, a potent inhibitor of human cathepsin L
1693:
951:
positive regulation of chemokine (C-X-C motif) ligand 2 production
1095:
1091:
5576:
5571:
5561:
5551:
5546:
5541:
5496:
5486:
5446:
5375:
5345:
5340:
5335:
5330:
5325:
5320:
5275:
5245:
5150:
5118:
5113:
5093:
5083:
5078:
5063:
5058:
4959:
4954:
4923:
4903:
4898:
4888:
4883:
4762:
4715:
4675:
4330:
4325:
4320:
4315:
4300:
4291:
4286:
4281:
4266:
4224:
4219:
4209:
4204:
4187:
4182:
4172:
4167:
4162:
4157:
4152:
4147:
4083:
4056:
4051:
4046:
4021:
4016:
3953:
3948:
3943:
3933:
3928:
3881:
3876:
3871:
3861:
3856:
3839:
3834:
3829:
3819:
3814:
3799:
3794:
3789:
3779:
3774:
3769:
3752:
3747:
3742:
3693:
3661:
3656:
3651:
3634:
3629:
3624:
3619:
1491:
165:
3559:
3468:
5088:
3700:
3688:
3683:
3678:
3668:
3641:
3609:
3464:
1840:
Claesson L, Larhammar D, Rask L, Peterson PA (December 1983).
605:
1046:
positive regulation of I-kappaB kinase/NF-kappaB signaling
1031:
positive regulation of cytokine-mediated signaling pathway
971:
antigen processing and presentation of endogenous antigen
2063:
Owen JA, Punt J, Stranford SA, Jones PP, Kuby J (2013).
956:
macrophage migration inhibitory factor signaling pathway
916:
positive regulation of peptidyl-tyrosine phosphorylation
649:
MHC class II protein binding, via antigen binding groove
421:
1899:
Kudo J, Chao LY, Narni F, Saunders GF (December 1985).
1698:
Role of CD74 receptor in tissue injury and wound repair
775:
macrophage migration inhibitory factor receptor complex
921:
negative regulation of mature B cell apoptotic process
152:, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
996:
positive regulation of macrophage cytokine production
586:
3234:
Bijlmakers MJ, Benaroch P, Ploegh HL (August 1994).
5394:
5188:
4937:
4621:
4344:
4004:
3602:
2874:O'Sullivan DM, Noonan D, Quaranta V (August 1987).
1510:. It is involved in the formation and transport of
1465:
HLA class II histocompatibility antigen gamma chain
1377:
1340:
1310:
1273:
1061:
positive regulation of transcription, DNA-templated
1783:
1781:
1779:
1762:
1760:
1758:
1578:The stable MHC class II + antigen complex is then
2788:Marks MS, Blum JS, Cresswell P (September 1990).
1066:positive regulation of viral entry into host cell
368:
267:
1646:against CD74 have been identified as promising
1056:positive regulation of monocyte differentiation
1011:positive regulation of fibroblast proliferation
2096:Schulze MS, Wucherpfennig KW (February 2012).
1788:GRCm38: Ensembl release 89: ENSMUSG00000024610
1036:positive regulation of protein phosphorylation
881:chaperone cofactor-dependent protein refolding
659:macrophage migration inhibitory factor binding
3571:
3480:
991:negative regulation of T cell differentiation
891:positive regulation of type 2 immune response
861:positive regulation of T cell differentiation
8:
3530:: HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN
2058:
2056:
1021:positive regulation of ERK1 and ERK2 cascade
946:positive regulation of neutrophil chemotaxis
1767:GRCh38: Ensembl release 89: ENSG00000019582
1001:positive regulation of B cell proliferation
3578:
3564:
3556:
3487:
3473:
3465:
1469:HLA-DR antigens-associated invariant chain
1106:
830:clathrin-coated endocytic vesicle membrane
621:
409:
308:
205:
63:
3595:list of human clusters of differentiation
3422:at the U.S. National Library of Medicine
3394:
3384:
3259:
3090:
3065:Strubin M, Mach B, Long EO (April 1984).
2989:
2979:
2899:
2848:
2813:
2606:
2596:
2555:
2545:
2504:
2494:
2453:
2334:
2324:
2205:
2121:
2036:
2026:
1924:
1875:
1865:
1616:the vaccine that lacked the Ii adjuvant.
2744:Bakke O, Dobberstein B (November 1990).
2067:(7th ed.). New York: W.H. Freeman.
1686:(MIF) to mediate some of its functions.
1660:non-radiographic axial spondyloarthritis
1566:), leaving only a small fragment called
1514:peptide complexes for the generation of
986:negative regulation of peptide secretion
866:negative regulation of apoptotic process
3502:
1754:
1723:mmune) that predates the naming of the
936:immunoglobulin mediated immune response
16:Mammalian protein found in Homo sapiens
1684:Macrophage migration inhibitory factor
1524:macrophage migration inhibitory factor
1041:positive regulation of kinase activity
750:ER to Golgi transport vesicle membrane
18:
2831:Spiro RC, Quaranta V (October 1989).
373:
334:
329:
272:
231:
226:
7:
3240:The Journal of Experimental Medicine
2880:The Journal of Experimental Medicine
1664:radiographic axial spondyloarthritis
669:MHC class II protein complex binding
2483:The Journal of Biological Chemistry
1988:10.1146/annurev.iy.12.040194.001355
1607:(HCV) genomeβhas been tested as an
1081:protein-containing complex assembly
1051:positive regulation of MAPK cascade
926:regulation of macrophage activation
911:antigen processing and presentation
3083:10.1002/j.1460-2075.1984.tb01898.x
2579:Farr L, Ghosh S, Moonah S (2020).
2313:The Journal of Infectious Diseases
2009:Farr L, Ghosh S, Moonah S (2020).
1374:
1337:
1307:
1270:
1246:
1227:
1201:
1182:
1156:
1137:
961:prostaglandin biosynthetic process
790:intracellular anatomical structure
664:protein folding chaperone activity
591:
509:
447:
426:
14:
1949:"UniProtKB - P04233 (HG2A_HUMAN)"
1487:that in humans is encoded by the
3535:
3520:
3505:
2266:Annals of the Rheumatic Diseases
1725:Major Histocompatibility Complex
1621:vaccine for the SARS-CoV-2 virus
1564:cortical thymic epithelial cells
1006:negative thymic T cell selection
876:positive thymic T cell selection
840:external side of plasma membrane
595:
357:
350:
344:
321:
256:
249:
243:
218:
27:
2278:10.1136/annrheumdis-2012-202208
1506:which plays a critical role in
1016:intracellular protein transport
2186:Science Translational Medicine
2147:Trends in Biochemical Sciences
1955:. The UniProt Consortium. 2020
1650:in the early diagnosis of the
805:endoplasmic reticulum membrane
745:integral component of membrane
606:More reference expression data
575:More reference expression data
1:
2159:10.1016/s0968-0004(99)01364-x
2102:Current Opinion in Immunology
1595:The Ii moleculeβfused with a
1071:protein heterotetramerization
966:cell population proliferation
639:nitric-oxide synthase binding
342:
241:
3336:10.1016/0092-8674(93)90417-O
3129:10.1016/0092-8674(82)90090-3
2765:10.1016/0092-8674(90)90137-4
2644:10.1016/0161-5890(79)90027-0
2198:10.1126/scitranslmed.aaz7715
1744:the first Mab to target CD74
770:trans-Golgi network membrane
720:MHC class II protein complex
684:MHC class II protein binding
5608:Clusters of differentiation
5603:Genes on human chromosome 5
3591:clusters of differentiation
3166:10.4049/jimmunol.129.6.2564
2850:10.4049/jimmunol.143.8.2589
2794:The Journal of Cell Biology
1976:Annual Review of Immunology
1540:rough endoplasmic reticulum
5629:
3457:gene details page in the
2684:10.2174/157016206775197583
2399:10.1016/j.pain.2009.11.011
2237:Larkin M (June 24, 2020).
1737:Cluster of differentiation
740:transport vesicle membrane
735:endocytic vesicle membrane
654:cytokine receptor activity
3500:
3440:School of Crystallography
2114:10.1016/j.coi.2011.11.004
1953:The UniProt Knowledgebase
1823:"Mouse PubMed Reference:"
1805:"Human PubMed Reference:"
1483:ifferentiation 74), is a
1451:
1446:
1442:
1435:
1419:
1400:
1381:
1344:
1333:
1314:
1277:
1266:
1253:
1249:
1234:
1230:
1221:
1208:
1204:
1189:
1185:
1176:
1163:
1159:
1144:
1140:
1131:
1116:
1109:
1105:
1089:
644:identical protein binding
624:
620:
603:
594:
585:
572:
521:
512:
459:
450:
420:
412:
408:
391:
378:
341:
320:
311:
307:
290:
277:
240:
217:
208:
204:
159:
156:
146:
139:
134:
71:
66:
49:
44:
39:
35:
26:
21:
3424:Medical Subject Headings
2598:10.3389/fimmu.2020.01273
2028:10.3389/fimmu.2020.01273
1538:class II protein in the
1413:Chr 18: 60.94 β 60.95 Mb
1406:Chr 5: 150.4 β 150.41 Mb
906:adaptive immune response
3386:10.1073/pnas.90.18.8581
2981:10.1073/pnas.83.12.4484
2585:Frontiers in Immunology
2547:10.1186/1471-2407-9-230
2496:10.1074/jbc.M109.014589
2015:Frontiers in Immunology
1867:10.1073/pnas.80.24.7395
1656:axial spondyloarthritis
1639:Axial spondyloarthritis
491:upper lobe of left lung
2245:. GI Health Foundation
1917:10.1093/nar/13.24.8827
1905:Nucleic Acids Research
1699:
1668:Ankylosing spondylitis
375:18 E1|18 34.41 cM
3252:10.1084/jem.180.2.623
3154:Journal of Immunology
2892:10.1084/jem.166.2.444
2837:Journal of Immunology
2806:10.1083/jcb.111.3.839
2326:10.1093/infdis/jiz579
1697:
1586:Clinical significance
1520:cell surface receptor
1076:protein trimerization
976:immune system process
800:endoplasmic reticulum
715:extracellular exosome
336:Chromosome 18 (mouse)
3451:genome location and
2672:Current HIV Research
2632:Molecular Immunology
2366:(12): 2383β6, 2390.
1508:antigen presentation
694:CD4 receptor binding
674:amyloid-beta binding
561:white adipose tissue
234:Chromosome 5 (human)
67:List of PDB id codes
40:Available structures
3459:UCSC Genome Browser
3442:The Invariant Chain
3436:(student generated)
3420:CD74+protein,+human
3377:1993PNAS...90.8581R
3291:1993Natur.364...33B
3203:1995Natur.378..457G
3050:10.1021/bi00282a026
3021:10.1021/bi00343a023
2972:1986PNAS...83.4484O
2713:1992Natur.360..474R
2489:(47): 32483β32492.
2243:Reuters Health News
1858:1983PNAS...80.7395C
941:leukocyte migration
871:signal transduction
755:multivesicular body
2931:10.1007/BF00372530
1700:
1690:Recovery functions
1682:with the cytokine
1652:autoimmune disease
1211:ENSMUSG00000024610
849:Biological process
725:lysosomal membrane
703:Cellular component
632:Molecular function
495:lower lobe of lung
5590:
5589:
3553:
3552:
3371:(18): 8581β8585.
3197:(6556): 457β462.
3044:(13): 3206β3213.
3015:(22): 6185β6190.
2966:(12): 4484β4488.
2707:(6403): 474β477.
2440:(12): 2578β2591.
2192:(548): eaaz7715.
2074:978-1-4641-1991-0
1911:(24): 8827β8841.
1852:(24): 7395β7399.
1605:Hepatitis C virus
1522:for the cytokine
1462:
1461:
1458:
1457:
1431:
1430:
1396:
1395:
1371:
1370:
1329:
1328:
1304:
1303:
1262:
1261:
1243:
1242:
1217:
1216:
1198:
1197:
1172:
1171:
1153:
1152:
1101:
1100:
835:NOS2-CD74 complex
616:
615:
612:
611:
581:
580:
568:
567:
506:
505:
404:
403:
303:
302:
130:
129:
126:
125:
50:Ortholog search:
5620:
3580:
3573:
3566:
3557:
3539:
3524:
3509:
3489:
3482:
3475:
3466:
3434:Davidson College
3408:
3398:
3388:
3355:
3318:
3299:10.1038/364033a0
3273:
3263:
3230:
3211:10.1038/378457a0
3185:
3160:(6): 2564β2569.
3148:
3114:
3104:
3094:
3071:The EMBO Journal
3061:
3032:
3003:
2993:
2983:
2950:
2913:
2903:
2870:
2852:
2843:(8): 2589β2594.
2827:
2817:
2784:
2750:
2740:
2721:10.1038/360474a0
2695:
2656:
2655:
2627:
2621:
2620:
2610:
2600:
2576:
2570:
2569:
2559:
2549:
2525:
2519:
2518:
2508:
2498:
2474:
2468:
2467:
2457:
2425:
2419:
2418:
2382:
2376:
2375:
2355:
2349:
2348:
2338:
2328:
2319:(7): 1185β1193.
2304:
2298:
2297:
2272:(6): 1211β1214.
2261:
2255:
2254:
2252:
2250:
2234:
2228:
2227:
2209:
2177:
2171:
2170:
2142:
2136:
2135:
2125:
2093:
2087:
2086:
2060:
2051:
2050:
2040:
2030:
2006:
2000:
1999:
1971:
1965:
1964:
1962:
1960:
1945:
1939:
1938:
1928:
1896:
1890:
1889:
1879:
1869:
1837:
1831:
1830:
1819:
1813:
1812:
1801:
1795:
1785:
1774:
1764:
1601:conserved region
1591:Vaccine adjuvant
1444:
1443:
1415:
1408:
1391:
1375:
1366:
1338:
1334:RefSeq (protein)
1324:
1308:
1299:
1271:
1247:
1228:
1202:
1183:
1157:
1138:
1107:
981:defense response
886:T cell selection
689:cytokine binding
622:
608:
599:
592:
577:
517:
515:Top expressed in
510:
455:
453:Top expressed in
448:
427:
410:
400:
387:
376:
361:
354:
348:
337:
325:
309:
299:
286:
275:
260:
253:
247:
236:
222:
206:
200:
198:CD74 - orthologs
151:
144:
121:
64:
58:
37:
36:
31:
19:
5628:
5627:
5623:
5622:
5621:
5619:
5618:
5617:
5593:
5592:
5591:
5586:
5390:
5184:
4933:
4617:
4340:
4000:
3598:
3584:
3554:
3549:
3546:
3540:
3531:
3525:
3516:
3510:
3496:
3493:
3416:
3411:
3358:
3321:
3285:(6432): 33β39.
3276:
3233:
3188:
3151:
3112:
3107:
3064:
3035:
3006:
2953:
2916:
2873:
2830:
2787:
2748:
2743:
2698:
2669:
2665:
2663:Further reading
2660:
2659:
2629:
2628:
2624:
2578:
2577:
2573:
2527:
2526:
2522:
2476:
2475:
2471:
2446:10.1002/pro.263
2434:Protein Science
2427:
2426:
2422:
2384:
2383:
2379:
2357:
2356:
2352:
2306:
2305:
2301:
2263:
2262:
2258:
2248:
2246:
2236:
2235:
2231:
2179:
2178:
2174:
2144:
2143:
2139:
2095:
2094:
2090:
2075:
2065:Kuby immunology
2062:
2061:
2054:
2008:
2007:
2003:
1973:
1972:
1968:
1958:
1956:
1947:
1946:
1942:
1898:
1897:
1893:
1839:
1838:
1834:
1821:
1820:
1816:
1803:
1802:
1798:
1786:
1777:
1765:
1756:
1751:
1733:
1709:
1692:
1676:
1641:
1629:
1593:
1588:
1532:
1496:invariant chain
1453:View/Edit Mouse
1448:View/Edit Human
1411:
1404:
1401:Location (UCSC)
1387:
1383:
1362:
1358:
1354:
1350:
1346:
1320:
1316:
1295:
1291:
1287:
1283:
1279:
1192:ENSG00000019582
1085:
856:immune response
844:
810:plasma membrane
760:Golgi apparatus
710:lysosomal lumen
698:
679:protein binding
604:
573:
564:
559:
555:
551:
547:
543:
539:
535:
531:
527:
513:
502:
499:mucosa of ileum
497:
493:
489:
485:
481:
477:
473:
469:
465:
451:
395:
382:
374:
364:
363:
362:
355:
335:
312:Gene location (
294:
281:
273:
263:
262:
261:
254:
232:
209:Gene location (
160:
147:
140:
73:
51:
17:
12:
11:
5:
5626:
5624:
5616:
5615:
5610:
5605:
5595:
5594:
5588:
5587:
5585:
5584:
5579:
5574:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
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5409:
5404:
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5388:
5383:
5378:
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5333:
5328:
5323:
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5313:
5308:
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5288:
5283:
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5268:
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5223:
5218:
5213:
5208:
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5182:
5177:
5168:
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5148:
5143:
5138:
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5116:
5106:
5101:
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5066:
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5035:
5026:
5021:
5020:
5019:
5014:
5004:
4999:
4998:
4997:
4992:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4941:
4939:
4935:
4934:
4932:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
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4856:
4851:
4846:
4845:
4844:
4839:
4829:
4824:
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4814:
4813:
4812:
4807:
4802:
4792:
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4777:
4772:
4771:
4770:
4765:
4755:
4750:
4745:
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4735:
4730:
4725:
4724:
4723:
4718:
4708:
4702:
4697:
4692:
4687:
4678:
4673:
4672:
4671:
4666:
4661:
4651:
4646:
4641:
4636:
4631:
4625:
4623:
4619:
4618:
4616:
4615:
4610:
4605:
4600:
4595:
4590:
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4580:
4575:
4570:
4565:
4560:
4555:
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4545:
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4525:
4520:
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4510:
4505:
4500:
4495:
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4489:
4488:
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4472:
4471:
4466:
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4411:
4406:
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4341:
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4269:
4264:
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4195:
4185:
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4165:
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4118:
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4074:
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4029:
4024:
4019:
4014:
4008:
4006:
4002:
4001:
3999:
3998:
3993:
3992:
3991:
3986:
3981:
3976:
3971:
3966:
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3936:
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3807:
3802:
3797:
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3787:
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3665:
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3659:
3654:
3644:
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3632:
3627:
3622:
3617:
3606:
3604:
3600:
3599:
3585:
3583:
3582:
3575:
3568:
3560:
3551:
3550:
3548:
3547:
3541:
3534:
3532:
3526:
3519:
3517:
3511:
3504:
3501:
3498:
3497:
3494:
3492:
3491:
3484:
3477:
3469:
3463:
3462:
3443:
3437:
3427:
3415:
3414:External links
3412:
3410:
3409:
3356:
3330:(2): 257β268.
3319:
3274:
3246:(2): 623β629.
3231:
3186:
3149:
3105:
3077:(4): 869β872.
3062:
3033:
3004:
2951:
2919:Immunogenetics
2914:
2886:(2): 444β460.
2871:
2828:
2800:(3): 839β855.
2785:
2759:(4): 707β716.
2741:
2696:
2666:
2664:
2661:
2658:
2657:
2622:
2571:
2520:
2469:
2420:
2393:(2): 275β283.
2377:
2362:(in Chinese).
2350:
2299:
2256:
2229:
2172:
2153:(4): 150β154.
2137:
2108:(1): 105β111.
2088:
2073:
2052:
2001:
1966:
1940:
1891:
1832:
1814:
1796:
1775:
1753:
1752:
1750:
1747:
1746:
1745:
1739:
1732:
1729:
1708:
1705:
1691:
1688:
1678:CD74 receptor
1675:
1672:
1644:Autoantibodies
1640:
1637:
1628:
1625:
1592:
1589:
1587:
1584:
1531:
1528:
1467:also known as
1460:
1459:
1456:
1455:
1450:
1440:
1439:
1433:
1432:
1429:
1428:
1426:
1424:
1417:
1416:
1409:
1402:
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1326:
1312:
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1123:
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1113:
1103:
1102:
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1098:
1087:
1086:
1084:
1083:
1078:
1073:
1068:
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1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
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893:
888:
883:
878:
873:
868:
863:
858:
852:
850:
846:
845:
843:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
765:Golgi membrane
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
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681:
676:
671:
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661:
656:
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641:
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633:
629:
628:
618:
617:
614:
613:
610:
609:
601:
600:
589:
583:
582:
579:
578:
570:
569:
566:
565:
563:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
519:
518:
507:
504:
503:
501:
500:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
457:
456:
444:
443:
435:
424:
418:
417:
414:RNA expression
406:
405:
402:
401:
393:
389:
388:
380:
377:
372:
366:
365:
356:
349:
343:
339:
338:
333:
327:
326:
318:
317:
305:
304:
301:
300:
292:
288:
287:
279:
276:
271:
265:
264:
255:
248:
242:
238:
237:
230:
224:
223:
215:
214:
202:
201:
158:
154:
153:
145:
137:
136:
132:
131:
128:
127:
124:
123:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5625:
5614:
5613:Immune system
5611:
5609:
5606:
5604:
5601:
5600:
5598:
5583:
5580:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5408:
5405:
5403:
5400:
5399:
5397:
5393:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5193:
5191:
5187:
5181:
5178:
5176:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5120:
5117:
5115:
5112:
5111:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5039:
5036:
5034:
5030:
5027:
5025:
5022:
5018:
5015:
5013:
5010:
5009:
5008:
5005:
5003:
5000:
4996:
4993:
4991:
4988:
4987:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4940:
4936:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4843:
4840:
4838:
4835:
4834:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4811:
4808:
4806:
4803:
4801:
4798:
4797:
4796:
4793:
4791:
4788:
4786:
4783:
4781:
4778:
4776:
4773:
4769:
4766:
4764:
4761:
4760:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4722:
4719:
4717:
4714:
4713:
4712:
4709:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4682:
4679:
4677:
4674:
4670:
4667:
4665:
4662:
4660:
4657:
4656:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4635:
4632:
4630:
4627:
4626:
4624:
4620:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4494:
4491:
4487:
4484:
4482:
4479:
4478:
4477:
4474:
4470:
4467:
4465:
4462:
4461:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4393:
4390:
4388:
4385:
4384:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4349:
4347:
4343:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4232:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4199:
4196:
4194:
4191:
4190:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4113:
4112:
4109:
4105:
4102:
4100:
4097:
4095:
4092:
4091:
4090:
4087:
4085:
4082:
4078:
4075:
4073:
4070:
4068:
4065:
4064:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4009:
4007:
4003:
3997:
3994:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3961:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3904:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3851:
3848:
3846:
3843:
3842:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3764:
3761:
3759:
3756:
3755:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3713:
3712:
3709:
3707:
3704:
3702:
3699:
3695:
3692:
3691:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3663:
3660:
3658:
3655:
3653:
3650:
3649:
3648:
3645:
3643:
3640:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3612:
3611:
3608:
3607:
3605:
3601:
3596:
3592:
3588:
3581:
3576:
3574:
3569:
3567:
3562:
3561:
3558:
3544:
3538:
3533:
3529:
3523:
3518:
3514:
3508:
3503:
3499:
3490:
3485:
3483:
3478:
3476:
3471:
3470:
3467:
3460:
3456:
3455:
3450:
3449:
3444:
3441:
3438:
3435:
3431:
3428:
3425:
3421:
3418:
3417:
3413:
3406:
3402:
3397:
3392:
3387:
3382:
3378:
3374:
3370:
3366:
3362:
3357:
3353:
3349:
3345:
3341:
3337:
3333:
3329:
3325:
3320:
3316:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3284:
3280:
3275:
3271:
3267:
3262:
3257:
3253:
3249:
3245:
3241:
3237:
3232:
3228:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3196:
3192:
3187:
3183:
3179:
3175:
3171:
3167:
3163:
3159:
3155:
3150:
3146:
3142:
3138:
3134:
3130:
3126:
3122:
3118:
3111:
3106:
3102:
3098:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3063:
3059:
3055:
3051:
3047:
3043:
3039:
3034:
3030:
3026:
3022:
3018:
3014:
3010:
3005:
3001:
2997:
2992:
2987:
2982:
2977:
2973:
2969:
2965:
2961:
2957:
2952:
2948:
2944:
2940:
2936:
2932:
2928:
2924:
2920:
2915:
2911:
2907:
2902:
2897:
2893:
2889:
2885:
2881:
2877:
2872:
2868:
2864:
2860:
2856:
2851:
2846:
2842:
2838:
2834:
2829:
2825:
2821:
2816:
2811:
2807:
2803:
2799:
2795:
2791:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2747:
2742:
2738:
2734:
2730:
2726:
2722:
2718:
2714:
2710:
2706:
2702:
2697:
2693:
2689:
2685:
2681:
2677:
2673:
2668:
2667:
2662:
2653:
2649:
2645:
2641:
2637:
2633:
2626:
2623:
2618:
2614:
2609:
2604:
2599:
2594:
2590:
2586:
2582:
2575:
2572:
2567:
2563:
2558:
2553:
2548:
2543:
2539:
2535:
2531:
2524:
2521:
2516:
2512:
2507:
2502:
2497:
2492:
2488:
2484:
2480:
2473:
2470:
2465:
2461:
2456:
2451:
2447:
2443:
2439:
2435:
2431:
2424:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2392:
2388:
2381:
2378:
2373:
2369:
2365:
2361:
2354:
2351:
2346:
2342:
2337:
2332:
2327:
2322:
2318:
2314:
2310:
2303:
2300:
2295:
2291:
2287:
2283:
2279:
2275:
2271:
2267:
2260:
2257:
2244:
2240:
2233:
2230:
2225:
2221:
2217:
2213:
2208:
2203:
2199:
2195:
2191:
2187:
2183:
2176:
2173:
2168:
2164:
2160:
2156:
2152:
2148:
2141:
2138:
2133:
2129:
2124:
2119:
2115:
2111:
2107:
2103:
2099:
2092:
2089:
2084:
2080:
2076:
2070:
2066:
2059:
2057:
2053:
2048:
2044:
2039:
2034:
2029:
2024:
2020:
2016:
2012:
2005:
2002:
1997:
1993:
1989:
1985:
1981:
1977:
1970:
1967:
1954:
1950:
1944:
1941:
1936:
1932:
1927:
1922:
1918:
1914:
1910:
1906:
1902:
1895:
1892:
1887:
1883:
1878:
1873:
1868:
1863:
1859:
1855:
1851:
1847:
1843:
1836:
1833:
1828:
1824:
1818:
1815:
1810:
1806:
1800:
1797:
1793:
1789:
1784:
1782:
1780:
1776:
1772:
1768:
1763:
1761:
1759:
1755:
1748:
1743:
1740:
1738:
1735:
1734:
1730:
1728:
1726:
1722:
1718:
1714:
1713:Hugh McDevitt
1706:
1704:
1696:
1689:
1687:
1685:
1681:
1673:
1671:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1638:
1636:
1634:
1626:
1624:
1622:
1617:
1614:
1610:
1606:
1602:
1598:
1590:
1585:
1583:
1581:
1576:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1543:
1541:
1537:
1529:
1527:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1498:(Abbreviated
1497:
1493:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1454:
1449:
1445:
1441:
1438:
1434:
1427:
1425:
1422:
1418:
1414:
1410:
1407:
1403:
1399:
1392:
1390:
1386:
1380:
1376:
1373:
1367:
1365:
1361:
1357:
1353:
1349:
1343:
1339:
1336:
1332:
1325:
1323:
1319:
1313:
1309:
1306:
1300:
1298:
1294:
1290:
1286:
1282:
1276:
1272:
1269:
1267:RefSeq (mRNA)
1265:
1258:
1257:
1252:
1248:
1245:
1239:
1238:
1233:
1229:
1226:
1224:
1220:
1213:
1212:
1207:
1203:
1200:
1194:
1193:
1188:
1184:
1181:
1179:
1175:
1168:
1167:
1162:
1158:
1155:
1149:
1148:
1143:
1139:
1136:
1134:
1130:
1127:
1124:
1122:
1119:
1115:
1112:
1108:
1104:
1097:
1093:
1088:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
853:
851:
848:
847:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
730:late endosome
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
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631:
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627:
626:Gene ontology
623:
619:
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602:
598:
593:
590:
588:
584:
576:
571:
560:
557:adrenal gland
556:
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3364:
3327:
3323:
3282:
3278:
3243:
3239:
3194:
3190:
3157:
3153:
3123:(1): 61β69.
3120:
3116:
3074:
3070:
3041:
3038:Biochemistry
3037:
3012:
3009:Biochemistry
3008:
2963:
2959:
2925:(1): 53β56.
2922:
2918:
2883:
2879:
2840:
2836:
2797:
2793:
2756:
2752:
2704:
2700:
2678:(1): 57β64.
2675:
2671:
2638:(1): 51β60.
2635:
2631:
2625:
2588:
2584:
2574:
2537:
2533:
2523:
2486:
2482:
2472:
2437:
2433:
2423:
2390:
2386:
2380:
2363:
2359:
2353:
2316:
2312:
2302:
2269:
2265:
2259:
2247:. Retrieved
2242:
2232:
2189:
2185:
2175:
2150:
2146:
2140:
2105:
2101:
2091:
2064:
2018:
2014:
2004:
1979:
1975:
1969:
1957:. Retrieved
1952:
1943:
1908:
1904:
1894:
1849:
1845:
1835:
1826:
1817:
1808:
1799:
1720:
1716:
1710:
1701:
1677:
1674:Interactions
1642:
1630:
1618:
1597:viral vector
1594:
1577:
1544:
1534:The nascent
1533:
1512:MHC class II
1499:
1495:
1488:
1480:
1476:
1472:
1468:
1464:
1463:
1385:NP_001036070
1382:
1364:NP_001351013
1360:NP_001351012
1352:NP_001020330
1348:NP_001020329
1345:
1318:NM_001042605
1315:
1297:NM_001364084
1293:NM_001364083
1289:NM_001025159
1285:NM_001025158
1278:
1254:
1235:
1209:
1190:
1164:
1145:
1125:
1120:
785:cell surface
541:zone of skin
437:
430:
295:150,412,969
282:150,401,637
157:External IDs
72:
3495:PDB gallery
1982:: 259β293.
1742:Milatuzumab
1633:milatuzumab
1613:HCV vaccine
1560:cathepsin L
1556:cathepsin S
1552:MHC class I
1516:CD4+ T cell
1504:polypeptide
487:gallbladder
471:granulocyte
396:60,945,724
383:60,936,920
135:Identifiers
5597:Categories
3593:(see also
2534:BMC Cancer
1794:, May 2017
1773:, May 2017
1749:References
1648:biomarkers
1479:luster of
483:right lung
479:lymph node
441:(ortholog)
178:HomoloGene
2224:219722045
2083:820117219
1680:interacts
1580:presented
1389:NP_034675
1356:NP_004346
1322:NM_010545
1281:NM_004355
1111:Orthologs
186:GeneCards
3587:Proteins
3430:Overview
3352:10295196
3182:42620266
2781:19993336
2692:16454711
2617:32655566
2591:: 1273.
2566:19602265
2515:19759012
2464:19827093
2415:38141283
2407:20005040
2372:20034881
2345:31677380
2294:22939188
2286:23687263
2216:32554708
2167:10322421
2132:22138314
2047:32655566
2021:: 1273.
1790:–
1769:–
1731:See also
1609:adjuvant
1548:endosome
1530:Function
1437:Wikidata
1090:Sources:
825:endosome
815:lysosome
780:membrane
467:appendix
463:monocyte
5395:301β350
5189:251β300
5141:CD240CE
4938:201β250
4622:151β200
4345:101β150
3405:8397411
3373:Bibcode
3344:8343954
3315:4248668
3307:8316295
3287:Bibcode
3270:7519244
3261:2191624
3227:4275956
3219:7477400
3199:Bibcode
3174:6982931
3145:9066996
3137:6955026
3101:6586420
3058:6576808
3029:3866610
3000:3459184
2968:Bibcode
2947:2418453
2939:3132422
2910:3036998
2901:2189580
2867:6755576
2859:2507633
2824:2391366
2815:2116304
2773:2121367
2737:4338656
2729:1448172
2709:Bibcode
2608:7325688
2557:2716369
2540:: 230.
2506:2781663
2455:2798171
2336:7325720
2249:Aug 10,
2207:7610808
2123:3288754
2038:7325688
1996:8011283
1959:Aug 10,
1935:3001652
1886:6324166
1854:Bibcode
1792:Ensembl
1771:Ensembl
1707:History
1654:called
1603:of the
1526:(MIF).
1502:) is a
1485:protein
1223:UniProt
1178:Ensembl
1117:Species
1096:QuickGO
820:vacuole
529:jejunum
416:pattern
142:Aliases
5402:CD300A
5361:CDw293
5146:CD240D
5007:CD213a
4985:CDw210
4950:CD202b
4924:CDw199
4919:CDw198
4573:CD140b
4005:51β100
3445:Human
3426:(MeSH)
3403:
3393:
3350:
3342:
3313:
3305:
3279:Nature
3268:
3258:
3225:
3217:
3191:Nature
3180:
3172:
3143:
3135:
3099:
3092:557440
3089:
3056:
3027:
2998:
2991:323758
2988:
2945:
2937:
2908:
2898:
2865:
2857:
2822:
2812:
2779:
2771:
2735:
2727:
2701:Nature
2690:
2652:376435
2650:
2615:
2605:
2564:
2554:
2513:
2503:
2462:
2452:
2413:
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2343:
2333:
2292:
2284:
2222:
2214:
2204:
2165:
2130:
2120:
2081:
2071:
2045:
2035:
1994:
1933:
1926:318954
1923:
1884:
1877:389957
1874:
1627:Cancer
1611:for a
1572:HLA-DM
1494:. The
1423:search
1421:PubMed
1256:P04441
1237:P04233
1133:Entrez
587:BioGPS
553:uterus
533:thymus
525:spleen
475:spleen
274:5q33.1
166:142790
5582:CD350
5577:CD349
5572:CD344
5567:CD340
5562:CD339
5557:CD338
5552:CD337
5547:CD336
5542:CD335
5537:CD334
5532:CD333
5527:CD332
5522:CD331
5517:CD329
5512:CD328
5507:CD327
5502:CD326
5497:CD325
5492:CD324
5487:CD322
5482:CD321
5477:CD320
5472:CD318
5467:CD317
5462:CD316
5457:CD315
5452:CD314
5447:CD312
5442:CD309
5437:CD307
5432:CD306
5427:CD305
5422:CD304
5417:CD303
5412:CD302
5407:CD301
5386:CD299
5381:CD298
5376:CD297
5371:CD295
5366:CD294
5356:CD292
5351:CD290
5346:CD289
5341:CD288
5336:CD286
5331:CD284
5326:CD283
5321:CD282
5316:CD281
5311:CD280
5306:CD279
5301:CD278
5296:CD276
5291:CD275
5286:CD274
5281:CD273
5276:CD272
5271:CD271
5266:CD269
5261:CD268
5256:CD267
5251:CD266
5246:CD265
5241:CD264
5236:CD263
5231:CD262
5226:CD261
5221:CD258
5216:CD257
5211:CD256
5206:CD254
5201:CD253
5196:CD252
5180:CD249
5175:CD248
5171:CD247
5166:CD246
5161:CD244
5156:CD243
5151:CD241
5136:CD239
5131:CD238
5126:CD236
5109:CD235
5104:CD234
5099:CD233
5094:CD230
5089:CD229
5084:CD228
5079:CD227
5074:CD226
5069:CD225
5064:CD224
5059:CD223
5054:CD222
5049:CD221
5044:CD220
5029:CD218
5024:CD217
5002:CD212
4980:CD209
4975:CD208
4970:CD207
4965:CD206
4960:CD205
4955:CD204
4945:CD201
4929:CD200
4914:CD197
4909:CD196
4904:CD195
4899:CD194
4894:CD193
4889:CD192
4884:CD191
4879:CD186
4874:CD185
4869:CD184
4864:CD183
4859:CD182
4854:CD181
4849:CD180
4832:CD179
4827:CD178
4822:CD177
4817:CD174
4795:CD172
4790:CD171
4785:CD170
4780:CD169
4775:CD168
4758:CD167
4753:CD166
4748:CD164
4743:CD163
4738:CD162
4733:CD161
4728:CD160
4711:CD159
4681:CD158
4676:CD157
4654:CD156
4649:CD155
4644:CD154
4639:CD153
4634:CD152
4629:CD151
4613:CD150
4608:CD148
4603:CD147
4598:CD146
4593:CD144
4588:CD143
4583:CD142
4578:CD141
4568:CD138
4563:CD137
4558:CD136
4553:CD135
4548:CD134
4543:CD133
4538:CD132
4533:CD131
4528:CD130
4523:CD129
4518:CD127
4513:CD126
4508:CD125
4503:CD124
4498:CD123
4493:CD122
4476:CD121
4459:CD120
4454:CD119
4449:CD118
4444:CD117
4439:CD116
4434:CD115
4429:CD114
4424:CD113
4419:CD112
4414:CD111
4409:CD110
4404:CD109
4399:CD108
4382:CD107
4377:CD106
4372:CD105
4367:CD104
4362:CD103
4357:CD102
4352:CD101
4336:CD100
3396:47401
3348:S2CID
3311:S2CID
3223:S2CID
3178:S2CID
3141:S2CID
3113:(PDF)
2943:S2CID
2863:S2CID
2777:S2CID
2749:(PDF)
2733:S2CID
2411:S2CID
2290:S2CID
2220:S2CID
1599:to a
1166:16149
1126:Mouse
1121:Human
1092:Amigo
545:colon
537:ileum
439:Mouse
432:Human
379:Start
314:Mouse
278:Start
211:Human
174:96534
4331:CD99
4326:CD98
4321:CD97
4316:CD96
4311:CD95
4306:CD94
4301:CD93
4296:CD92
4292:CD91
4287:CD90
4282:CD89
4277:CD88
4272:CD87
4267:CD86
4230:CD85
4225:CD84
4220:CD83
4215:CD82
4210:CD81
4205:CD80
4188:CD79
4183:CD78
4178:CD74
4173:CD73
4168:CD72
4163:CD71
4158:CD70
4153:CD69
4148:CD68
4111:CD66
4089:CD64
4084:CD63
4062:CD62
4057:CD61
4052:CD59
4047:CD58
4042:CD57
4037:CD56
4032:CD55
4027:CD54
4022:CD53
4017:CD52
4012:CD51
3996:CD50
3959:CD49
3954:CD48
3949:CD47
3944:CD46
3939:CD45
3934:CD44
3929:CD43
3902:CD42
3897:CD41
3892:CD40
3887:CD39
3882:CD38
3877:CD37
3872:CD36
3867:CD35
3862:CD34
3857:CD33
3840:CD32
3835:CD31
3830:CD30
3825:CD29
3820:CD28
3815:CD27
3810:CD26
3805:CD25
3800:CD24
3795:CD23
3790:CD22
3785:CD21
3780:CD20
3775:CD19
3770:CD18
3753:CD16
3748:CD15
3743:CD14
3738:CD13
3711:CD11
3706:CD10
3603:1β50
3543:1l3h
3528:1iie
3513:1icf
3454:CD74
3448:CD74
3401:PMID
3340:PMID
3324:Cell
3303:PMID
3266:PMID
3215:PMID
3170:PMID
3133:PMID
3117:Cell
3097:PMID
3054:PMID
3025:PMID
2996:PMID
2935:PMID
2906:PMID
2855:PMID
2820:PMID
2769:PMID
2753:Cell
2725:PMID
2688:PMID
2648:PMID
2613:PMID
2562:PMID
2511:PMID
2460:PMID
2403:PMID
2387:Pain
2368:PMID
2341:PMID
2282:PMID
2251:2020
2212:PMID
2163:PMID
2128:PMID
2079:OCLC
2069:ISBN
2043:PMID
1992:PMID
1961:2020
1931:PMID
1882:PMID
1719:for
1670:).
1662:and
1568:CLIP
1492:gene
1489:CD74
1473:CD74
422:Bgee
370:Band
331:Chr.
269:Band
228:Chr.
190:CD74
182:3209
162:OMIM
149:CD74
119:4X5W
115:4AEN
111:3QXD
107:3QXA
103:3PGD
99:3PGC
95:3PDO
91:1MUJ
87:1L3H
83:1IIE
79:1ICF
75:1A6A
56:RCSB
53:PDBe
22:CD74
3701:CD9
3689:CD8
3684:CD7
3679:CD6
3674:CD5
3669:CD4
3647:CD3
3642:CD2
3615:a-c
3610:CD1
3432:at
3391:PMC
3381:doi
3332:doi
3295:doi
3283:364
3256:PMC
3248:doi
3244:180
3207:doi
3195:378
3162:doi
3158:129
3125:doi
3087:PMC
3079:doi
3046:doi
3017:doi
2986:PMC
2976:doi
2927:doi
2896:PMC
2888:doi
2884:166
2845:doi
2841:143
2810:PMC
2802:doi
2798:111
2761:doi
2717:doi
2705:360
2680:doi
2640:doi
2603:PMC
2593:doi
2552:PMC
2542:doi
2501:PMC
2491:doi
2487:284
2450:PMC
2442:doi
2395:doi
2391:148
2331:PMC
2321:doi
2317:221
2274:doi
2202:PMC
2194:doi
2155:doi
2118:PMC
2110:doi
2033:PMC
2023:doi
1984:doi
1921:PMC
1913:doi
1872:PMC
1862:doi
1727:.
1562:in
1536:MHC
1471:or
1147:972
549:lip
392:End
291:End
194:OMA
170:MGI
46:PDB
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