345:
322:
219:
244:
2384:
603:
596:
610:
2369:
2399:
351:
250:
40:
1374:
cascade initiated by the plasminogen activation system. uPAR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. When urokinase is bound to the receptor, there is cleavage between the GPI-anchor and the uPAR, releasing a soluble form of the
66:
2183:
Ploug M, Gårdsvoll H, Jørgensen TJ, Lønborg Hansen L, Danø K (April 2002). "Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy".
1697:
Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M (February 2006). "Structure of human urokinase plasminogen activator in complex with its receptor".
2250:
Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, Caputi M, Carriero MV, Iaccarino I, Stoppelli MP (February 2005). "The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis".
2383:
3300:
2439:
2154:
Chavakis T, Kanse SM, May AE, Preissner KT (April 2002). "Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation".
2032:"Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity"
358:
257:
1832:
3290:
3270:
933:
180:
914:
4132:
2456:
2432:
2368:
1830:
Desmedt S, Desmedt V, Delanghe JR, Speeckaert R, Speeckaert MM (2017). "The
Intriguing Role of Soluble Urokinase Receptor in Inflammatory Diseases".
1775:
3863:
2213:
Alfano M, Sidenius N, Blasi F, Poli G (November 2003). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection".
3851:
3629:
4464:
3915:
3910:
3856:
3636:
2417:
2348:
1589:
1392:
2398:
1571:
4469:
3369:
3295:
2425:
1370:. In order to be able to reorganize tissue, the old tissue must be able to be degraded. An important mechanism in this degradation is the
4398:
4393:
4388:
4383:
3310:
2117:
Kjøller L (January 2002). "The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility".
344:
1157:
1301:
and with its native ligand, urokinase. All three three-finger domains are necessary for high affinity binding of the primary ligand,
4363:
1164:
321:
3599:
1427:
4167:
3661:
3347:
1558:
1537:
3806:
3342:
243:
218:
1554:
63:
4303:
3775:
3770:
3715:
3449:
2898:
2392:: Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A
1533:
3997:
3720:
160:
2086:"Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor"
3315:
2085:
1468:
357:
256:
4027:
2452:
1993:
1489:
1325:
350:
249:
2893:
2341:
1989:"The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role"
4077:
2972:
2299:
978:
168:
1448:
of the various components of the plasminogen activation system have been sought as possible anticancer drugs.
4041:
1334:
959:
1609:"The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions"
3384:
3379:
3374:
3364:
2671:
2599:
1408:
2728:
2646:
1650:"Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide"
1291:
232:
3965:
3678:
2334:
1890:
1707:
1412:
1287:
147:
3992:
3811:
1433:
The components of the plasminogen activation system have been found to be highly expressed in many
1423:
1298:
1115:
1111:
1107:
1056:
1052:
1048:
784:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
2295:
3399:
2276:
2238:
2142:
1857:
1731:
1362:
activation system, which in the healthy body is involved in tissue reorganization events such as
192:
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1081:
1060:
2306:
2268:
2230:
2201:
2171:
2134:
2105:
2061:
2012:
1969:
1918:
1849:
1807:
1723:
1679:
1630:
1329:
1318:
602:
595:
140:
56:
1451:
uPAR has been involved in various other non-proteolytic processes related to cancer, such as
1387:
Soluble urokinase plasminogen activator receptor (suPAR) has been found to be a biomarker of
4172:
3905:
3826:
3389:
2582:
2508:
2260:
2222:
2193:
2163:
2126:
2097:
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2002:
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312:
267:
1648:
Llinas P, Le Du MH, Gårdsvoll H, Danø K, Ploug M, Gilquin B, Stura EA, Ménez A (May 2005).
609:
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1607:
Kessler, Pascal; Marchot, Pascale; Silva, Marcela; Servent, Denis (August 2017).
196:
4353:
4002:
3780:
3755:
3454:
3076:
3002:
2476:
1594:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1576:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1371:
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1955:
1494:
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1441:
1263:
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176:
2101:
1665:
1266:(GPI) anchor. uPAR was originally identified as a saturable binding site for
4122:
4117:
4112:
4102:
4097:
4092:
4087:
1719:
1509:
1434:
1302:
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295:
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184:
2272:
2234:
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2175:
2138:
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2016:
2007:
1988:
1973:
1922:
1913:
1853:
1811:
1750:
1727:
1683:
1634:
2047:
1792:
1305:. In addition, uPAR also interacts with several other proteins, including
1204:
1199:
4428:
4328:
4142:
4127:
3330:
3325:
3233:
2923:
2264:
1314:
1188:
1023:
1004:
834:
positive regulation of epidermal growth factor receptor signaling pathway
2226:
2130:
4378:
4373:
4368:
4268:
4082:
4072:
3899:
3878:
3873:
3841:
3646:
3566:
3561:
3556:
3551:
3546:
3464:
3157:
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2987:
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2448:
2320:
2310:
2197:
2167:
1499:
1343:
1295:
1241:
990:
945:
1625:
1608:
1440:, indicating that tumors are able to hijack the system, and use it in
117:
113:
109:
105:
101:
97:
93:
89:
85:
4318:
4278:
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3434:
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2955:
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2888:
2758:
2748:
2711:
2706:
2624:
2619:
1484:
1396:
1310:
1172:
900:
151:, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor
17:
4443:
4418:
4338:
4333:
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4293:
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3459:
3424:
3419:
3414:
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3404:
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3253:
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3223:
3218:
3213:
3167:
3059:
3054:
2873:
2857:
2850:
2845:
2840:
2835:
2830:
2825:
2800:
2778:
2773:
2666:
2592:
2587:
2577:
1504:
1437:
1376:
1938:"Senolytic CAR T cells reverse senescence-associated pathologies"
863:
859:
4438:
4433:
4423:
4413:
4408:
4403:
4358:
4348:
4308:
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3019:
3014:
3009:
2945:
2918:
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2908:
2883:
2878:
2815:
2810:
2805:
2795:
2790:
2743:
2738:
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2723:
2718:
2701:
2696:
2691:
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2676:
2661:
2656:
2651:
2641:
2636:
2631:
2614:
2609:
2604:
2555:
2523:
2518:
2513:
2496:
2491:
2486:
2481:
2319:(Human Urokinase plasminogen activator surface receptor) at the
1472:
1248:
824:
positive regulation of release of cytochrome c from mitochondria
164:
2421:
2377:: crystal structure of urokinase plasminogen activator receptor
2330:
618:
3950:
2562:
2550:
2545:
2540:
2530:
2503:
2471:
2326:
1422:
Urokinase receptors have been found to be highly expressed on
2305:
Overview of all the structural information available in the
794:
negative regulation of intrinsic apoptotic signaling pathway
2030:
Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG (May 2001).
1419:
have significantly higher suPAR compared to non-smokers.
420:
1324:
It has been possible to express uPAR recombinantly in
2407:: Crystal structure of ATF-urokinase receptor complex
585:
4256:
4050:
3799:
3483:
3206:
2866:
2464:
1133:
1100:
1074:
1041:
1550:
1548:
1546:
1529:
1527:
1525:
1290:family. The structure of uPAR has been solved by
799:urokinase plasminogen activator signaling pathway
662:urokinase plasminogen activator receptor activity
367:
266:
1833:Critical Reviews in Clinical Laboratory Sciences
1222:urokinase plasminogen activator surface receptor
1825:
1823:
1821:
1555:GRCm38: Ensembl release 89: ENSMUSG00000046223
779:positive regulation of protein phosphorylation
2433:
2342:
8:
1534:GRCh38: Ensembl release 89: ENSG00000011422
2440:
2426:
2418:
2349:
2335:
2327:
874:
634:
408:
307:
204:
74:
2457:list of human clusters of differentiation
2298:at the U.S. National Library of Medicine
2055:
2006:
1963:
1912:
1902:
1877:"T Cells Engineered to Target Senescence"
1801:
1791:
1673:
1624:
1270:(also known as uPA) on the cell surface.
1774:Thunø M, Macho B, Eugen-Olsen J (2009).
804:negative regulation of apoptotic process
2364:
1521:
27:Mammalian protein found in Homo sapiens
1430:to eliminate senescent cells in mice.
29:
1467:Urokinase receptor has been shown to
1393:chronic obstructive pulmonary disease
723:integral component of plasma membrane
372:
333:
328:
271:
230:
225:
7:
532:endothelial cell of lymphatic vessel
1776:"suPAR: the molecular crystal ball"
814:attachment of GPI anchor to protein
1936:Amor C, Feucht J, Lowe SW (2020).
1342:sites are used in vivo giving the
1130:
1097:
1071:
1038:
1014:
995:
969:
950:
924:
905:
829:positive regulation of DNA binding
590:
508:
446:
425:
25:
1428:chimeric antigen receptor T cells
2397:
2382:
2367:
2186:Biochemical Society Transactions
2156:Biochemical Society Transactions
608:
601:
594:
356:
349:
343:
320:
255:
248:
242:
217:
38:
1459:regulation, and cell adhesion.
1309:, the uPAR associated protein (
748:extrinsic component of membrane
652:protein domain specific binding
1278:uPAR consists of three tandem
738:anchored component of membrane
708:endoplasmic reticulum membrane
693:integral component of membrane
619:More reference expression data
574:More reference expression data
1:
2090:Current Pharmaceutical Design
2036:Molecular Biology of the Cell
1846:10.1080/10408363.2016.1269310
1426:, leading researchers to use
1338:. 4 out of 5 of the possible
341:
240:
4465:Genes on human chromosome 19
2215:Journal of Leukocyte Biology
1391:. Elevated suPAR is seen in
1264:glycosylphosphotidylinositol
4470:Clusters of differentiation
2453:clusters of differentiation
703:endoplasmic reticulum lumen
677:signaling receptor activity
470:stromal cell of endometrium
4486:
2253:Thrombosis and Haemostasis
1994:Thrombosis and Haemostasis
1904:10.1038/d41586-020-01759-x
1490:Cluster of differentiation
1354:Physiological significance
672:signaling receptor binding
2362:
1956:10.1038/s41586-020-2403-9
1755:suPARnostic® by ViroGates
1613:Journal of Neurochemistry
1590:"Mouse PubMed Reference:"
1572:"Human PubMed Reference:"
1274:Molecular characteristics
1244:encoded in humans by the
1203:
1198:
1194:
1187:
1171:
1152:
1137:
1104:
1093:
1078:
1045:
1034:
1021:
1017:
1002:
998:
989:
976:
972:
957:
953:
944:
931:
927:
912:
908:
899:
884:
877:
873:
857:
839:regulation of proteolysis
758:specific granule membrane
637:
633:
616:
593:
584:
571:
520:
511:
458:
449:
419:
411:
407:
390:
377:
340:
319:
310:
306:
289:
276:
239:
216:
207:
203:
158:
155:
145:
138:
133:
82:
77:
60:
55:
50:
46:
37:
32:
2300:Medical Subject Headings
2102:10.2174/1381612033454630
1875:Wagner V, Gil J (2020).
1666:10.1038/sj.emboj.7600635
1158:Chr 19: 43.65 – 43.67 Mb
849:neutrophil degranulation
1720:10.1126/science.1121143
1335:Drosophila melanogaster
1165:Chr 7: 24.16 – 24.18 Mb
2008:10.1055/s-0038-1675399
1987:Josip Madunić (2018).
1409:cardiovascular disease
1358:uPAR is a part of the
556:mucous cell of stomach
2048:10.1091/mbc.12.5.1467
1383:Clinical significance
1292:X-ray crystallography
743:extracellular exosome
552:stroma of bone marrow
233:Chromosome 19 (human)
2296:PLAUR+protein,+human
2265:10.1160/TH04-09-0592
2119:Biological Chemistry
1413:rheumatoid arthritis
1288:three-finger protein
728:extracellular region
335:Chromosome 7 (mouse)
78:List of PDB id codes
51:Available structures
2227:10.1189/jlb.0403176
2131:10.1515/BC.2002.002
1895:2020Natur.583...37W
1793:10.1155/2009/504294
1712:2006Sci...311..656H
844:signal transduction
2198:10.1042/BST0300177
2168:10.1042/BST0300168
1294:in complex with a
1218:Urokinase receptor
979:ENSMUSG00000046223
772:Biological process
686:Cellular component
645:Molecular function
536:tibiofemoral joint
4452:
4451:
2415:
2414:
2001:(12): 2020–2036.
1950:(7814): 127–132.
1626:10.1111/jnc.13975
1375:protein known as
1319:membrane proteins
1214:
1213:
1210:
1209:
1183:
1182:
1148:
1147:
1127:
1126:
1089:
1088:
1068:
1067:
1030:
1029:
1011:
1010:
985:
984:
966:
965:
940:
939:
921:
920:
869:
868:
809:blood coagulation
629:
628:
625:
624:
580:
579:
567:
566:
505:
504:
486:bone marrow cells
462:periodontal fiber
403:
402:
302:
301:
197:PLAUR - orthologs
129:
128:
125:
124:
61:Ortholog search:
16:(Redirected from
4477:
2442:
2435:
2428:
2419:
2401:
2386:
2371:
2351:
2344:
2337:
2328:
2284:
2246:
2209:
2179:
2150:
2113:
2096:(19): 1499–528.
2084:Ploug M (2003).
2070:
2069:
2059:
2027:
2021:
2020:
2010:
1984:
1978:
1977:
1967:
1933:
1927:
1926:
1916:
1906:
1872:
1866:
1865:
1827:
1816:
1815:
1805:
1795:
1771:
1765:
1764:
1762:
1761:
1746:
1740:
1739:
1694:
1688:
1687:
1677:
1654:The EMBO Journal
1645:
1639:
1638:
1628:
1604:
1598:
1597:
1586:
1580:
1579:
1568:
1562:
1552:
1541:
1531:
1348:molecular weight
1258:tethered to the
1220:, also known as
1196:
1195:
1167:
1160:
1143:
1131:
1122:
1098:
1094:RefSeq (protein)
1084:
1072:
1063:
1039:
1015:
996:
970:
951:
925:
906:
875:
635:
621:
612:
605:
598:
591:
576:
516:
514:Top expressed in
509:
490:cartilage tissue
454:
452:Top expressed in
447:
426:
409:
399:
386:
375:
360:
353:
347:
336:
324:
308:
298:
285:
274:
259:
252:
246:
235:
221:
205:
199:
150:
143:
120:
75:
69:
48:
47:
42:
30:
21:
4485:
4484:
4480:
4479:
4478:
4476:
4475:
4474:
4455:
4454:
4453:
4448:
4252:
4046:
3795:
3479:
3202:
2862:
2460:
2446:
2416:
2411:
2408:
2402:
2393:
2387:
2378:
2372:
2358:
2355:
2292:
2287:
2249:
2212:
2182:
2153:
2116:
2083:
2079:
2077:Further reading
2074:
2073:
2029:
2028:
2024:
1986:
1985:
1981:
1935:
1934:
1930:
1889:(7814): 37–38.
1874:
1873:
1869:
1829:
1828:
1819:
1780:Disease Markers
1773:
1772:
1768:
1759:
1757:
1751:"What is suPAR"
1748:
1747:
1743:
1706:(5761): 656–9.
1696:
1695:
1691:
1647:
1646:
1642:
1606:
1605:
1601:
1588:
1587:
1583:
1570:
1569:
1565:
1553:
1544:
1532:
1523:
1518:
1481:
1465:
1424:senescent cells
1385:
1366:involution and
1356:
1284:protein domains
1276:
1236:ifferentiation
1205:View/Edit Mouse
1200:View/Edit Human
1163:
1156:
1153:Location (UCSC)
1139:
1118:
1114:
1110:
1106:
1080:
1059:
1055:
1051:
1047:
960:ENSG00000011422
853:
767:
753:plasma membrane
698:cell projection
681:
657:protein binding
617:
607:
606:
600:
599:
572:
563:
558:
554:
550:
546:
542:
540:right lung lobe
538:
534:
530:
526:
512:
501:
496:
492:
488:
484:
480:
476:
472:
468:
464:
450:
394:
381:
373:
363:
362:
361:
354:
334:
311:Gene location (
293:
280:
272:
262:
261:
260:
253:
231:
208:Gene location (
159:
146:
139:
84:
62:
28:
23:
22:
15:
12:
11:
5:
4483:
4481:
4473:
4472:
4467:
4457:
4456:
4450:
4449:
4447:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4260:
4258:
4254:
4253:
4251:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4054:
4052:
4048:
4047:
4045:
4044:
4039:
4030:
4025:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3985:
3984:
3983:
3978:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3897:
3888:
3883:
3882:
3881:
3876:
3866:
3861:
3860:
3859:
3854:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3803:
3801:
3797:
3796:
3794:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3707:
3706:
3701:
3691:
3686:
3681:
3676:
3675:
3674:
3669:
3664:
3654:
3649:
3644:
3639:
3634:
3633:
3632:
3627:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3586:
3585:
3580:
3570:
3564:
3559:
3554:
3549:
3540:
3535:
3534:
3533:
3528:
3523:
3513:
3508:
3503:
3498:
3493:
3487:
3485:
3481:
3480:
3478:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3351:
3350:
3345:
3335:
3334:
3333:
3328:
3318:
3313:
3308:
3303:
3298:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3257:
3256:
3251:
3241:
3236:
3231:
3226:
3221:
3216:
3210:
3208:
3204:
3203:
3201:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3151:
3146:
3141:
3136:
3131:
3126:
3125:
3124:
3119:
3114:
3109:
3104:
3099:
3089:
3084:
3079:
3074:
3069:
3064:
3063:
3062:
3057:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3006:
3005:
3000:
2995:
2990:
2985:
2980:
2970:
2969:
2968:
2963:
2958:
2948:
2943:
2942:
2941:
2936:
2931:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2870:
2868:
2864:
2863:
2861:
2860:
2855:
2854:
2853:
2848:
2843:
2838:
2833:
2828:
2818:
2813:
2808:
2803:
2798:
2793:
2788:
2787:
2786:
2781:
2776:
2771:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2715:
2714:
2709:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2628:
2627:
2622:
2612:
2607:
2602:
2597:
2596:
2595:
2590:
2585:
2580:
2570:
2565:
2560:
2559:
2558:
2548:
2543:
2538:
2533:
2528:
2527:
2526:
2521:
2516:
2506:
2501:
2500:
2499:
2494:
2489:
2484:
2479:
2468:
2466:
2462:
2461:
2447:
2445:
2444:
2437:
2430:
2422:
2413:
2412:
2410:
2409:
2403:
2396:
2394:
2388:
2381:
2379:
2373:
2366:
2363:
2360:
2359:
2356:
2354:
2353:
2346:
2339:
2331:
2325:
2324:
2303:
2291:
2290:External links
2288:
2286:
2285:
2247:
2210:
2180:
2151:
2114:
2080:
2078:
2075:
2072:
2071:
2042:(5): 1467–79.
2022:
1979:
1928:
1867:
1840:(2): 117–133.
1817:
1766:
1741:
1689:
1660:(9): 1655–63.
1640:
1599:
1581:
1563:
1542:
1520:
1519:
1517:
1514:
1513:
1512:
1507:
1502:
1497:
1492:
1487:
1480:
1477:
1464:
1461:
1453:cell migration
1384:
1381:
1355:
1352:
1350:of 50–60 kDA.
1275:
1272:
1212:
1211:
1208:
1207:
1202:
1192:
1191:
1185:
1184:
1181:
1180:
1178:
1176:
1169:
1168:
1161:
1154:
1150:
1149:
1146:
1145:
1135:
1134:
1128:
1125:
1124:
1102:
1101:
1095:
1091:
1090:
1087:
1086:
1076:
1075:
1069:
1066:
1065:
1043:
1042:
1036:
1032:
1031:
1028:
1027:
1019:
1018:
1012:
1009:
1008:
1000:
999:
993:
987:
986:
983:
982:
974:
973:
967:
964:
963:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
891:
886:
882:
881:
871:
870:
867:
866:
855:
854:
852:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
775:
773:
769:
768:
766:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
718:focal adhesion
715:
710:
705:
700:
695:
689:
687:
683:
682:
680:
679:
674:
669:
667:enzyme binding
664:
659:
654:
648:
646:
642:
641:
631:
630:
627:
626:
623:
622:
614:
613:
588:
582:
581:
578:
577:
569:
568:
565:
564:
562:
561:
557:
553:
549:
545:
541:
537:
533:
529:
525:
521:
518:
517:
506:
503:
502:
500:
499:
495:
491:
487:
483:
479:
475:
471:
467:
463:
459:
456:
455:
443:
442:
434:
423:
417:
416:
413:RNA expression
405:
404:
401:
400:
392:
388:
387:
379:
376:
371:
365:
364:
355:
348:
342:
338:
337:
332:
326:
325:
317:
316:
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
229:
223:
222:
214:
213:
201:
200:
157:
153:
152:
144:
136:
135:
131:
130:
127:
126:
123:
122:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4482:
4471:
4468:
4466:
4463:
4462:
4460:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4261:
4259:
4255:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4055:
4053:
4049:
4043:
4040:
4038:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3982:
3979:
3977:
3974:
3973:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3901:
3898:
3896:
3892:
3889:
3887:
3884:
3880:
3877:
3875:
3872:
3871:
3870:
3867:
3865:
3862:
3858:
3855:
3853:
3850:
3849:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3804:
3802:
3798:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3705:
3702:
3700:
3697:
3696:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3673:
3670:
3668:
3665:
3663:
3660:
3659:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3631:
3628:
3626:
3623:
3622:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3584:
3581:
3579:
3576:
3575:
3574:
3571:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3544:
3541:
3539:
3536:
3532:
3529:
3527:
3524:
3522:
3519:
3518:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3488:
3486:
3482:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3349:
3346:
3344:
3341:
3340:
3339:
3336:
3332:
3329:
3327:
3324:
3323:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3255:
3252:
3250:
3247:
3246:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3211:
3209:
3205:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3094:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3061:
3058:
3056:
3053:
3052:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2975:
2974:
2971:
2967:
2964:
2962:
2959:
2957:
2954:
2953:
2952:
2949:
2947:
2944:
2940:
2937:
2935:
2932:
2930:
2927:
2926:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2871:
2869:
2865:
2859:
2856:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2823:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2766:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2713:
2710:
2708:
2705:
2704:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2626:
2623:
2621:
2618:
2617:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2575:
2574:
2571:
2569:
2566:
2564:
2561:
2557:
2554:
2553:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2525:
2522:
2520:
2517:
2515:
2512:
2511:
2510:
2507:
2505:
2502:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2474:
2473:
2470:
2469:
2467:
2463:
2458:
2454:
2450:
2443:
2438:
2436:
2431:
2429:
2424:
2423:
2420:
2406:
2400:
2395:
2391:
2385:
2380:
2376:
2370:
2365:
2361:
2352:
2347:
2345:
2340:
2338:
2333:
2332:
2329:
2322:
2318:
2317:
2312:
2308:
2304:
2301:
2297:
2294:
2293:
2289:
2282:
2278:
2274:
2270:
2266:
2262:
2259:(2): 205–11.
2258:
2254:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2211:
2207:
2203:
2199:
2195:
2192:(2): 177–83.
2191:
2187:
2181:
2177:
2173:
2169:
2165:
2162:(2): 168–73.
2161:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2120:
2115:
2111:
2107:
2103:
2099:
2095:
2091:
2087:
2082:
2081:
2076:
2067:
2063:
2058:
2053:
2049:
2045:
2041:
2037:
2033:
2026:
2023:
2018:
2014:
2009:
2004:
2000:
1996:
1995:
1990:
1983:
1980:
1975:
1971:
1966:
1961:
1957:
1953:
1949:
1945:
1944:
1939:
1932:
1929:
1924:
1920:
1915:
1914:10044/1/80980
1910:
1905:
1900:
1896:
1892:
1888:
1884:
1883:
1878:
1871:
1868:
1863:
1859:
1855:
1851:
1847:
1843:
1839:
1835:
1834:
1826:
1824:
1822:
1818:
1813:
1809:
1804:
1799:
1794:
1789:
1786:(3): 157–72.
1785:
1781:
1777:
1770:
1767:
1756:
1752:
1745:
1742:
1737:
1733:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1693:
1690:
1685:
1681:
1676:
1671:
1667:
1663:
1659:
1655:
1651:
1644:
1641:
1636:
1632:
1627:
1622:
1618:
1614:
1610:
1603:
1600:
1595:
1591:
1585:
1582:
1577:
1573:
1567:
1564:
1560:
1556:
1551:
1549:
1547:
1543:
1539:
1535:
1530:
1528:
1526:
1522:
1515:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1482:
1478:
1476:
1474:
1470:
1462:
1460:
1458:
1454:
1449:
1447:
1443:
1439:
1436:
1431:
1429:
1425:
1420:
1418:
1414:
1410:
1406:
1405:heart failure
1402:
1401:liver failure
1398:
1394:
1390:
1382:
1380:
1378:
1373:
1369:
1368:wound healing
1365:
1364:mammary gland
1361:
1353:
1351:
1349:
1345:
1341:
1340:glycosylation
1337:
1336:
1331:
1327:
1322:
1320:
1316:
1312:
1308:
1304:
1300:
1297:
1293:
1289:
1285:
1281:
1273:
1271:
1269:
1265:
1261:
1260:cell membrane
1257:
1254:
1250:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1206:
1201:
1197:
1193:
1190:
1186:
1179:
1177:
1174:
1170:
1166:
1162:
1159:
1155:
1151:
1144:
1142:
1136:
1132:
1129:
1123:
1121:
1117:
1113:
1109:
1103:
1099:
1096:
1092:
1085:
1083:
1077:
1073:
1070:
1064:
1062:
1058:
1054:
1050:
1044:
1040:
1037:
1035:RefSeq (mRNA)
1033:
1026:
1025:
1020:
1016:
1013:
1007:
1006:
1001:
997:
994:
992:
988:
981:
980:
975:
971:
968:
962:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
895:
892:
890:
887:
883:
880:
876:
872:
865:
861:
856:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
776:
774:
771:
770:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
733:cell junction
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
690:
688:
685:
684:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
649:
647:
644:
643:
640:
639:Gene ontology
636:
632:
620:
615:
611:
604:
597:
592:
589:
587:
583:
575:
570:
559:
555:
551:
547:
543:
539:
535:
531:
527:
523:
522:
519:
515:
510:
507:
497:
493:
489:
485:
481:
477:
473:
469:
465:
461:
460:
457:
453:
448:
445:
444:
441:
439:
435:
433:
432:
428:
427:
424:
422:
418:
414:
410:
406:
398:
393:
389:
385:
380:
370:
366:
359:
352:
346:
339:
331:
327:
323:
318:
314:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
234:
228:
224:
220:
215:
211:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
154:
149:
142:
137:
132:
121:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3970:
3890:
3868:
3846:
3693:
3656:
3619:
3572:
3542:
3515:
3337:
3243:
3133:
3091:
2820:
2572:
2404:
2389:
2374:
2314:
2256:
2252:
2221:(5): 750–6.
2218:
2214:
2189:
2185:
2159:
2155:
2122:
2118:
2093:
2089:
2039:
2035:
2025:
1998:
1992:
1982:
1947:
1941:
1931:
1886:
1880:
1870:
1837:
1831:
1783:
1779:
1769:
1758:. Retrieved
1754:
1744:
1703:
1699:
1692:
1657:
1653:
1643:
1616:
1612:
1602:
1593:
1584:
1575:
1566:
1466:
1463:Interactions
1450:
1432:
1421:
1389:inflammation
1386:
1357:
1333:
1323:
1282:, which are
1277:
1256:glycoprotein
1245:
1237:
1233:
1229:
1225:
1221:
1217:
1215:
1138:
1116:NP_001287966
1112:NP_001005377
1108:NP_001005376
1105:
1079:
1057:NM_001301037
1053:NM_001005377
1049:NM_001005376
1046:
1022:
1003:
977:
958:
932:
913:
893:
888:
789:fibrinolysis
763:cell surface
436:
429:
156:External IDs
83:
2357:PDB gallery
2125:(1): 5–19.
1749:ViroGates.
1372:proteolysis
1360:plasminogen
1332:cells from
1307:vitronectin
1253:multidomain
544:bone marrow
524:granulocyte
494:granulocyte
478:gallbladder
395:24,175,393
382:24,161,909
374:7|7 A3
294:43,670,547
281:43,646,095
134:Identifiers
4459:Categories
2455:(see also
1760:2021-09-27
1561:, May 2017
1540:, May 2017
1516:References
1495:Metastasis
1457:cell cycle
1446:inhibitors
1442:metastasis
1317:family of
1313:) and the
1299:antagonist
1280:LU domains
1251:. It is a
1232:luster of
1224:(uPAR) or
819:chemotaxis
498:right lung
440:(ortholog)
177:HomoloGene
1510:Urokinase
1435:malignant
1326:CHO-cells
1303:urokinase
1268:urokinase
1141:NP_035243
1120:NP_002650
1082:NM_011113
1061:NM_002659
879:Orthologs
474:vena cava
185:GeneCards
2449:Proteins
2281:35517406
2273:15711734
2235:12960238
2206:12023847
2176:12023845
2139:11928822
2110:12871065
2066:11359936
2017:30419600
1974:32555459
1923:32601490
1862:32624995
1854:28084848
1812:19893210
1736:39521660
1728:16456079
1684:15861141
1635:28326549
1619:: 7–18.
1557:–
1536:–
1479:See also
1469:interact
1315:integrin
1240:), is a
1189:Wikidata
858:Sources:
713:membrane
548:calvaria
466:monocyte
273:19q13.31
4257:301–350
4051:251–300
4003:CD240CE
3800:201–250
3484:151–200
3207:101–150
2321:PDBe-KB
2311:UniProt
2243:8526093
2147:6125978
1965:7583560
1891:Bibcode
1803:3835059
1708:Bibcode
1700:Science
1675:1142576
1559:Ensembl
1538:Ensembl
1500:Plasmin
1444:. Thus
1417:Smokers
1344:protein
1296:peptide
1286:of the
1262:with a
1242:protein
991:UniProt
946:Ensembl
885:Species
864:QuickGO
528:decidua
415:pattern
141:Aliases
4264:CD300A
4223:CDw293
4008:CD240D
3869:CD213a
3847:CDw210
3812:CD202b
3786:CDw199
3781:CDw198
3435:CD140b
2867:51–100
2316:Q03405
2302:(MeSH)
2279:
2271:
2241:
2233:
2204:
2174:
2145:
2137:
2108:
2064:
2054:
2015:
1972:
1962:
1943:Nature
1921:
1882:Nature
1860:
1852:
1810:
1800:
1734:
1726:
1682:
1672:
1633:
1485:Cancer
1438:tumors
1411:, and
1397:asthma
1311:uPARAP
1175:search
1173:PubMed
1024:P35456
1005:Q03405
901:Entrez
586:BioGPS
560:spleen
165:173391
4444:CD350
4439:CD349
4434:CD344
4429:CD340
4424:CD339
4419:CD338
4414:CD337
4409:CD336
4404:CD335
4399:CD334
4394:CD333
4389:CD332
4384:CD331
4379:CD329
4374:CD328
4369:CD327
4364:CD326
4359:CD325
4354:CD324
4349:CD322
4344:CD321
4339:CD320
4334:CD318
4329:CD317
4324:CD316
4319:CD315
4314:CD314
4309:CD312
4304:CD309
4299:CD307
4294:CD306
4289:CD305
4284:CD304
4279:CD303
4274:CD302
4269:CD301
4248:CD299
4243:CD298
4238:CD297
4233:CD295
4228:CD294
4218:CD292
4213:CD290
4208:CD289
4203:CD288
4198:CD286
4193:CD284
4188:CD283
4183:CD282
4178:CD281
4173:CD280
4168:CD279
4163:CD278
4158:CD276
4153:CD275
4148:CD274
4143:CD273
4138:CD272
4133:CD271
4128:CD269
4123:CD268
4118:CD267
4113:CD266
4108:CD265
4103:CD264
4098:CD263
4093:CD262
4088:CD261
4083:CD258
4078:CD257
4073:CD256
4068:CD254
4063:CD253
4058:CD252
4042:CD249
4037:CD248
4033:CD247
4028:CD246
4023:CD244
4018:CD243
4013:CD241
3998:CD239
3993:CD238
3988:CD236
3971:CD235
3966:CD234
3961:CD233
3956:CD230
3951:CD229
3946:CD228
3941:CD227
3936:CD226
3931:CD225
3926:CD224
3921:CD223
3916:CD222
3911:CD221
3906:CD220
3891:CD218
3886:CD217
3864:CD212
3842:CD209
3837:CD208
3832:CD207
3827:CD206
3822:CD205
3817:CD204
3807:CD201
3791:CD200
3776:CD197
3771:CD196
3766:CD195
3761:CD194
3756:CD193
3751:CD192
3746:CD191
3741:CD186
3736:CD185
3731:CD184
3726:CD183
3721:CD182
3716:CD181
3711:CD180
3694:CD179
3689:CD178
3684:CD177
3679:CD174
3657:CD172
3652:CD171
3647:CD170
3642:CD169
3637:CD168
3620:CD167
3615:CD166
3610:CD164
3605:CD163
3600:CD162
3595:CD161
3590:CD160
3573:CD159
3543:CD158
3538:CD157
3516:CD156
3511:CD155
3506:CD154
3501:CD153
3496:CD152
3491:CD151
3475:CD150
3470:CD148
3465:CD147
3460:CD146
3455:CD144
3450:CD143
3445:CD142
3440:CD141
3430:CD138
3425:CD137
3420:CD136
3415:CD135
3410:CD134
3405:CD133
3400:CD132
3395:CD131
3390:CD130
3385:CD129
3380:CD127
3375:CD126
3370:CD125
3365:CD124
3360:CD123
3355:CD122
3338:CD121
3321:CD120
3316:CD119
3311:CD118
3306:CD117
3301:CD116
3296:CD115
3291:CD114
3286:CD113
3281:CD112
3276:CD111
3271:CD110
3266:CD109
3261:CD108
3244:CD107
3239:CD106
3234:CD105
3229:CD104
3224:CD103
3219:CD102
3214:CD101
3198:CD100
2277:S2CID
2239:S2CID
2143:S2CID
2057:34598
1858:S2CID
1732:S2CID
1505:suPAR
1471:with
1377:suPAR
1246:PLAUR
934:18793
894:Mouse
889:Human
860:Amigo
482:blood
438:Mouse
431:Human
378:Start
313:Mouse
277:Start
210:Human
189:PLAUR
181:48120
173:97612
148:PLAUR
33:PLAUR
3193:CD99
3188:CD98
3183:CD97
3178:CD96
3173:CD95
3168:CD94
3163:CD93
3158:CD92
3154:CD91
3149:CD90
3144:CD89
3139:CD88
3134:CD87
3129:CD86
3092:CD85
3087:CD84
3082:CD83
3077:CD82
3072:CD81
3067:CD80
3050:CD79
3045:CD78
3040:CD74
3035:CD73
3030:CD72
3025:CD71
3020:CD70
3015:CD69
3010:CD68
2973:CD66
2951:CD64
2946:CD63
2924:CD62
2919:CD61
2914:CD59
2909:CD58
2904:CD57
2899:CD56
2894:CD55
2889:CD54
2884:CD53
2879:CD52
2874:CD51
2858:CD50
2821:CD49
2816:CD48
2811:CD47
2806:CD46
2801:CD45
2796:CD44
2791:CD43
2764:CD42
2759:CD41
2754:CD40
2749:CD39
2744:CD38
2739:CD37
2734:CD36
2729:CD35
2724:CD34
2719:CD33
2702:CD32
2697:CD31
2692:CD30
2687:CD29
2682:CD28
2677:CD27
2672:CD26
2667:CD25
2662:CD24
2657:CD23
2652:CD22
2647:CD21
2642:CD20
2637:CD19
2632:CD18
2615:CD16
2610:CD15
2605:CD14
2600:CD13
2573:CD11
2568:CD10
2465:1–50
2405:2i9b
2390:2fd6
2375:1ywh
2309:for
2269:PMID
2231:PMID
2202:PMID
2172:PMID
2135:PMID
2106:PMID
2062:PMID
2013:PMID
1970:PMID
1919:PMID
1850:PMID
1808:PMID
1724:PMID
1680:PMID
1631:PMID
1473:LRP1
1328:and
1249:gene
1226:CD87
1216:The
915:5329
421:Bgee
369:Band
330:Chr.
268:Band
227:Chr.
161:OMIM
118:4QTI
114:4K24
110:2I9B
106:3U74
102:3U73
98:3BT2
94:3BT1
90:2FD6
86:1YWH
67:RCSB
64:PDBe
18:CD87
2563:CD9
2551:CD8
2546:CD7
2541:CD6
2536:CD5
2531:CD4
2509:CD3
2504:CD2
2477:a-c
2472:CD1
2307:PDB
2261:doi
2223:doi
2194:doi
2164:doi
2127:doi
2123:383
2098:doi
2052:PMC
2044:doi
2003:doi
1999:118
1960:PMC
1952:doi
1948:583
1909:hdl
1899:doi
1887:583
1842:doi
1798:PMC
1788:doi
1716:doi
1704:311
1670:PMC
1662:doi
1621:doi
1617:142
391:End
290:End
193:OMA
169:MGI
57:PDB
4461::
4035:-
3156:-
2497:1E
2492:1D
2487:1B
2482:1A
2451::
2313::
2275:.
2267:.
2257:93
2255:.
2237:.
2229:.
2219:74
2217:.
2200:.
2190:30
2188:.
2170:.
2160:30
2158:.
2141:.
2133:.
2121:.
2104:.
2092:.
2088:.
2060:.
2050:.
2040:12
2038:.
2034:.
2011:.
1997:.
1991:.
1968:.
1958:.
1946:.
1940:.
1917:.
1907:.
1897:.
1885:.
1879:.
1856:.
1848:.
1838:54
1836:.
1820:^
1806:.
1796:.
1784:27
1782:.
1778:.
1753:.
1730:.
1722:.
1714:.
1702:.
1678:.
1668:.
1658:24
1656:.
1652:.
1629:.
1615:.
1611:.
1592:.
1574:.
1545:^
1524:^
1475:.
1455:,
1415:.
1407:,
1403:,
1399:,
1395:,
1379:.
1346:a
1330:S2
1321:.
1238:87
862:/
397:bp
384:bp
296:bp
283:bp
191:;
187::
183:;
179::
175:;
171::
167:;
163::
116:,
112:,
108:,
104:,
100:,
96:,
92:,
88:,
3981:b
3976:a
3902:)
3900:b
3895:a
3893:(
3879:2
3874:1
3857:b
3852:a
3704:b
3699:a
3672:g
3667:b
3662:a
3630:b
3625:a
3583:c
3578:a
3569:)
3567:k
3562:i
3557:e
3552:d
3547:a
3545:(
3531:c
3526:b
3521:a
3348:b
3343:a
3331:b
3326:a
3254:b
3249:a
3122:k
3117:j
3112:h
3107:e
3102:d
3097:a
3060:b
3055:a
3003:f
2998:e
2993:d
2988:c
2983:b
2978:a
2966:C
2961:B
2956:A
2939:P
2934:L
2929:E
2851:f
2846:e
2841:d
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