297:
274:
171:
196:
548:
303:
202:
2777:
50:
1126:, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcripts of this gene encode proteins that share the N-terminal sequence but completely differ in the C-terminus.
2191:
Yang W, Zhang A, Han Y, Su X, Chen Y, Zhao W (2021). "Cyclin-Dependent Kinase
Inhibitor 2b Controls Fibrosis and Functional Changes in Ischemia-Induced Heart Failure via the BMI1-p15-Rb Signalling Pathway".
2153:
Kudoh K, Ichikawa Y, Yoshida S, Hirai M, Kikuchi Y, Nagata I, et al. (June 2002). "Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer".
2080:
Simon M, Park TW, Köster G, Mahlberg R, Hackenbroch M, Boström J, et al. (December 2001). "Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression".
1603:
Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, et al. (April 1995). "Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer".
1582:
Stone S, Dayananth P, Jiang P, Weaver-Feldhaus JM, Tavtigian SV, Cannon-Albright L, Kamb A (September 1995). "Genomic structure, expression and mutational analysis of the P15 (MTS2) gene".
1503:
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome".
1561:
Hall M, Bates S, Peters G (October 1995). "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins".
1868:"Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines"
1452:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1122:, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by
2059:
Agiostratidou G, Derventzi A, Gonos ES (2002). "Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines".
1759:"Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells"
310:
209:
1987:
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. (April 2001). "Repression of p15INK4b expression by Myc through association with Miz-1".
2282:
1800:
Iavarone A, Massagué J (May 1997). "Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15".
1845:
Tsubari M, Tiihonen E, Laiho M (July 1997). "Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor".
801:
132:
782:
2574:
2468:
1107:
1625:
Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, et al. (December 1994). "Deletion of p16 and p15 genes in brain tumors".
2846:
2822:
1219:
1201:
2841:
2514:
2236:
296:
1903:"Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data"
1009:
2275:
2041:
1016:
2024:
Orlow I, Cordon-Cardo C (2002). "Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors".
1307:"CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A"
273:
1291:
1188:
1167:
1123:
1648:"Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function"
2248:
1184:
195:
170:
47:
1163:
2268:
112:
2584:
1135:
309:
208:
103:, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
2725:
2428:
1724:"The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2"
302:
201:
1106:
in a region that is frequently mutated, deleted, or disregulated in a wide variety of cancer. This gene encodes a
2815:
2423:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2383:
1139:
1237:
Hannon GJ, Beach D (September 1994). "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest".
846:
120:
2375:
827:
2707:
2458:
1099:
2808:
1809:
1694:
1461:
1408:
1246:
184:
2118:
Scarisbrick JJ, Woolford AJ, Calonje E, Photiou A, Ferreira S, Orchard G, et al. (March 2002).
99:
2254:
2242:
2720:
2525:
2217:
2179:
2106:
2012:
1833:
1538:
1485:
1270:
144:
1681:
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, et al. (April 1994).
992:
971:
967:
941:
920:
916:
547:
2715:
2209:
2171:
2141:
2098:
2068:
2047:
2037:
2004:
1975:
1932:
1889:
1854:
1825:
1788:
1745:
1710:
1669:
1634:
1613:
1591:
1570:
1530:
1477:
1434:
1377:
1336:
1262:
92:
40:
2792:
2201:
2163:
2131:
2090:
2029:
1996:
1965:
1957:
1922:
1914:
1879:
1817:
1778:
1770:
1735:
1702:
1659:
1520:
1512:
1469:
1424:
1416:
1367:
1326:
1318:
1254:
389:
320:
264:
219:
140:
1356:"Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma"
2120:"Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome"
1525:
364:
1813:
1698:
1465:
1412:
1250:
1927:
1902:
1757:
Sandhu C, Garbe J, Bhattacharya N, Daksis J, Pan CH, Yaswen P, et al. (May 1997).
1429:
1396:
1331:
1306:
1970:
1945:
1783:
1758:
1646:
Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, et al. (December 1994).
1395:
Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (January 2008).
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
625:
620:
615:
599:
594:
589:
2835:
2654:
2221:
2136:
2119:
1354:
Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, et al. (July 2015).
576:
2110:
2016:
2788:
2676:
1837:
1542:
1489:
1274:
382:
161:
124:
2183:
1372:
1355:
652:
positive regulation of transforming growth factor beta receptor signaling pathway
148:
2697:
2666:
2033:
1224:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1206:
National Center for
Biotechnology Information, U.S. National Library of Medicine
712:
negative regulation of cyclin-dependent protein serine/threonine kinase activity
2205:
1516:
1292:"Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)"
465:
2618:
2502:
2291:
2094:
1103:
281:
178:
128:
1884:
1867:
2741:
2691:
2681:
2364:
2360:
2350:
2346:
2342:
2332:
2328:
2318:
2314:
1706:
1683:"A cell cycle regulator potentially involved in genesis of many tumor types"
746:
525:
403:
348:
335:
247:
234:
136:
2213:
2175:
2145:
2102:
2072:
2051:
2008:
1979:
1936:
1893:
1534:
1481:
1438:
1381:
1340:
1858:
1829:
1792:
1774:
1749:
1714:
1673:
1664:
1647:
1638:
1617:
1595:
1574:
1266:
1056:
1051:
2746:
2686:
2671:
2640:
2626:
2356:
2338:
2324:
2310:
1740:
1723:
1397:"Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA"
1322:
1119:
1040:
891:
872:
1918:
1473:
1420:
2755:
2662:
2635:
2294:
1080:
858:
813:
657:
regulation of cyclin-dependent protein serine/threonine kinase activity
2260:
2167:
1961:
1305:
Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, et al. (January 2018).
69:
2594:
2510:
2496:
2492:
2480:
2438:
2433:
2302:
2000:
1821:
1258:
1024:
768:
2776:
1682:
595:
cyclin-dependent protein serine/threonine kinase inhibitor activity
2569:
2564:
2453:
2448:
2443:
731:
727:
2784:
2598:
2589:
2559:
2538:
2476:
1866:
Rich JN, Zhang M, Datto MB, Bigner DD, Wang XF (December 1999).
1115:
1111:
1087:
116:
2264:
556:
2579:
2543:
2533:
2506:
2484:
1110:, also known as p15Ink4b protein, which forms a complex with
677:
negative regulation of G1/S transition of mitotic cell cycle
1134:
CDKN2B tumor suppressor gene product p15 has been shown to
702:
positive regulation of transcription by RNA polymerase II
1946:"DNA cloning using in vitro site-specific recombination"
372:
2796:
1901:
Yuan C, Selby TL, Li J, Byeon IJ, Tsai MD (June 2000).
537:
2028:. Methods Mol. Biol. Vol. 179. pp. 43–59.
1118:, and prevents the activation of the CDK kinases by
707:
negative regulation of cell population proliferation
687:
negative regulation of epithelial cell proliferation
2734:
2706:
2653:
2617:
2608:
2552:
2524:
2467:
2374:
2301:
985:
960:
934:
909:
1944:Hartley JL, Temple GF, Brasch MA (November 2000).
1180:
1178:
1176:
1159:
1157:
1155:
319:
218:
16:Protein-coding gene in the species Homo sapiens
1185:GRCm38: Ensembl release 89: ENSMUSG00000073802
2816:
2276:
8:
1722:Reynisdóttir I, Massagué J (February 1997).
1164:GRCh38: Ensembl release 89: ENSG00000147883
642:cellular response to extracellular stimulus
2823:
2809:
2614:
2283:
2269:
2261:
742:
572:
504:transitional epithelium of urinary bladder
360:
259:
156:
58:
2575:Cellular apoptosis susceptibility protein
2135:
1969:
1926:
1883:
1782:
1739:
1663:
1524:
1428:
1371:
1330:
2124:The Journal of Investigative Dermatology
1286:
1284:
1151:
662:mitotic cell cycle checkpoint signaling
697:negative regulation of phosphorylation
18:
1069:Cyclin-dependent kinase 4 inhibitor B
682:G2/M transition of mitotic cell cycle
324:
285:
280:
223:
182:
177:
7:
2773:
2771:
496:endothelial cell of lymphatic vessel
1872:The Journal of Biological Chemistry
2795:. You can help Knowledge (XXG) by
982:
957:
931:
906:
882:
863:
837:
818:
792:
773:
542:
460:
398:
377:
14:
1108:cyclin-dependent kinase inhibitor
2775:
2137:10.1046/j.0022-202x.2001.01682.x
546:
308:
301:
295:
272:
207:
200:
194:
169:
2156:International Journal of Cancer
1098:This gene lies adjacent to the
2194:Canadian Journal of Cardiology
1763:Molecular and Cellular Biology
1526:11858/00-001M-0000-0010-8592-0
557:More reference expression data
526:More reference expression data
1:
2847:Human chromosome 9 gene stubs
672:cellular response to nutrient
647:megakaryocyte differentiation
293:
192:
1373:10.1158/2159-8290.CD-14-1096
2842:Genes on human chromosome 9
2585:Maturation promoting factor
2241:human gene location in the
1073:multiple tumor suppressor 2
2863:
2770:
2726:Postreplication checkpoint
2253:human gene details in the
2206:10.1016/j.cjca.2020.05.016
1517:10.1016/j.cell.2005.08.029
430:mucosa of transverse colon
2083:Journal of Neuro-Oncology
2034:10.1385/1-59259-238-4:043
1220:"Mouse PubMed Reference:"
1202:"Human PubMed Reference:"
1140:cyclin-dependent kinase 4
1055:
1050:
1046:
1039:
1023:
1004:
989:
964:
953:
938:
913:
902:
889:
885:
870:
866:
857:
844:
840:
825:
821:
812:
799:
795:
780:
776:
767:
752:
745:
741:
725:
575:
571:
554:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1885:10.1074/jbc.274.49.35053
2095:10.1023/A:1013863630293
1728:Genes & Development
1707:10.1126/science.8153634
1652:Genes & Development
1083:that is encoded by the
1017:Chr 4: 89.22 – 89.23 Mb
422:mucosa of sigmoid colon
2708:Cell cycle checkpoints
600:protein kinase binding
500:mucous cell of stomach
2735:Other cellular phases
2459:CDK-activating kinase
1775:10.1128/MCB.17.5.2458
1665:10.1101/gad.8.24.2939
476:epithelium of stomach
1741:10.1101/gad.11.4.492
1323:10.1038/onc.2017.316
1010:Chr 9: 22 – 22.01 Mb
326:4 C4|4 42.15 cM
287:Chromosome 4 (mouse)
185:Chromosome 9 (human)
62:List of PDB id codes
35:Available structures
2255:UCSC Genome Browser
2243:UCSC Genome Browser
1989:Nature Cell Biology
1919:10.1110/ps.9.6.1120
1814:1997Natur.387..417L
1699:1994Sci...264..436K
1474:10.1038/nature04209
1466:2005Natur.437.1173R
1421:10.1038/nature06468
1413:2008Natur.451..202Y
1251:1994Natur.371..257H
717:cellular senescence
512:conjunctival fornix
2783:This article on a
2721:Spindle checkpoint
2526:P53 p63 p73 family
847:ENSMUSG00000073802
667:spleen development
635:Biological process
609:Cellular component
583:Molecular function
438:buccal mucosa cell
149:CDKN2B - orthologs
2804:
2803:
2768:
2767:
2764:
2763:
2716:Restriction point
2168:10.1002/ijc.10331
1962:10.1101/gr.143000
1066:
1065:
1062:
1061:
1035:
1034:
1000:
999:
979:
978:
949:
948:
928:
927:
898:
897:
879:
878:
853:
852:
834:
833:
808:
807:
789:
788:
737:
736:
567:
566:
563:
562:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
2854:
2825:
2818:
2811:
2779:
2772:
2615:
2285:
2278:
2271:
2262:
2225:
2187:
2149:
2139:
2114:
2076:
2055:
2020:
2001:10.1038/35070076
1983:
1973:
1940:
1930:
1897:
1887:
1862:
1841:
1822:10.1038/387417a0
1808:(6631): 417–22.
1796:
1786:
1753:
1743:
1718:
1693:(5157): 436–40.
1677:
1667:
1642:
1621:
1599:
1578:
1547:
1546:
1528:
1500:
1494:
1493:
1460:(7062): 1173–8.
1449:
1443:
1442:
1432:
1392:
1386:
1385:
1375:
1360:Cancer Discovery
1351:
1345:
1344:
1334:
1302:
1296:
1295:
1288:
1279:
1278:
1259:10.1038/371257a0
1245:(6494): 257–61.
1234:
1228:
1227:
1216:
1210:
1209:
1198:
1192:
1182:
1171:
1161:
1100:tumor suppressor
1048:
1047:
1019:
1012:
995:
983:
974:
958:
954:RefSeq (protein)
944:
932:
923:
907:
883:
864:
838:
819:
793:
774:
743:
573:
559:
550:
543:
528:
468:
466:Top expressed in
461:
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
2862:
2861:
2857:
2856:
2855:
2853:
2852:
2851:
2832:
2831:
2830:
2829:
2769:
2760:
2750:
2730:
2702:
2649:
2644:
2630:
2610:
2604:
2548:
2520:
2463:
2370:
2297:
2289:
2233:
2228:
2190:
2152:
2117:
2079:
2058:
2044:
2023:
1986:
1956:(11): 1788–95.
1950:Genome Research
1943:
1907:Protein Science
1900:
1878:(49): 35053–8.
1865:
1853:(14): 2966–73.
1847:Cancer Research
1844:
1799:
1756:
1721:
1680:
1658:(24): 2939–52.
1645:
1627:Cancer Research
1624:
1606:Cancer Research
1602:
1581:
1560:
1556:
1554:Further reading
1551:
1550:
1502:
1501:
1497:
1451:
1450:
1446:
1407:(7175): 202–6.
1394:
1393:
1389:
1353:
1352:
1348:
1304:
1303:
1299:
1290:
1289:
1282:
1236:
1235:
1231:
1218:
1217:
1213:
1200:
1199:
1195:
1183:
1174:
1162:
1153:
1148:
1132:
1096:
1057:View/Edit Mouse
1052:View/Edit Human
1015:
1008:
1005:Location (UCSC)
991:
970:
966:
940:
919:
915:
828:ENSG00000147883
721:
630:
604:
590:protein binding
555:
524:
515:
510:
508:right lung lobe
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
418:mucosa of colon
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
2860:
2858:
2850:
2849:
2844:
2834:
2833:
2828:
2827:
2820:
2813:
2805:
2802:
2801:
2780:
2766:
2765:
2762:
2761:
2759:
2758:
2753:
2748:
2744:
2738:
2736:
2732:
2731:
2729:
2728:
2723:
2718:
2712:
2710:
2704:
2703:
2701:
2700:
2695:
2689:
2684:
2679:
2674:
2669:
2659:
2657:
2651:
2650:
2648:
2647:
2642:
2638:
2633:
2628:
2623:
2621:
2612:
2606:
2605:
2603:
2602:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2556:
2554:
2550:
2549:
2547:
2546:
2541:
2536:
2530:
2528:
2522:
2521:
2519:
2518:
2500:
2473:
2471:
2465:
2464:
2462:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2380:
2378:
2372:
2371:
2369:
2368:
2354:
2336:
2322:
2307:
2305:
2299:
2298:
2290:
2288:
2287:
2280:
2273:
2265:
2259:
2258:
2246:
2232:
2231:External links
2229:
2227:
2226:
2200:(4): 655–664.
2188:
2150:
2115:
2077:
2056:
2042:
2021:
1984:
1941:
1898:
1863:
1842:
1797:
1769:(5): 2458–67.
1754:
1734:(4): 492–503.
1719:
1678:
1643:
1633:(24): 6353–8.
1622:
1612:(7): 1448–51.
1600:
1579:
1557:
1555:
1552:
1549:
1548:
1495:
1444:
1387:
1346:
1317:(1): 128–138.
1297:
1280:
1229:
1211:
1193:
1172:
1150:
1149:
1147:
1144:
1131:
1128:
1095:
1092:
1071:also known as
1064:
1063:
1060:
1059:
1054:
1044:
1043:
1037:
1036:
1033:
1032:
1030:
1028:
1021:
1020:
1013:
1006:
1002:
1001:
998:
997:
987:
986:
980:
977:
976:
962:
961:
955:
951:
950:
947:
946:
936:
935:
929:
926:
925:
911:
910:
904:
900:
899:
896:
895:
887:
886:
880:
877:
876:
868:
867:
861:
855:
854:
851:
850:
842:
841:
835:
832:
831:
823:
822:
816:
810:
809:
806:
805:
797:
796:
790:
787:
786:
778:
777:
771:
765:
764:
759:
754:
750:
749:
739:
738:
735:
734:
723:
722:
720:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
638:
636:
632:
631:
629:
628:
623:
618:
612:
610:
606:
605:
603:
602:
597:
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
414:jejunal mucosa
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2859:
2848:
2845:
2843:
2840:
2839:
2837:
2826:
2821:
2819:
2814:
2812:
2807:
2806:
2800:
2798:
2794:
2790:
2786:
2781:
2778:
2774:
2757:
2754:
2752:
2745:
2743:
2740:
2739:
2737:
2733:
2727:
2724:
2722:
2719:
2717:
2714:
2713:
2711:
2709:
2705:
2699:
2696:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2664:
2661:
2660:
2658:
2656:
2652:
2646:
2639:
2637:
2634:
2632:
2625:
2624:
2622:
2620:
2616:
2613:
2607:
2600:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2557:
2555:
2551:
2545:
2542:
2540:
2537:
2535:
2532:
2531:
2529:
2527:
2523:
2516:
2512:
2508:
2504:
2501:
2498:
2494:
2490:
2486:
2482:
2478:
2475:
2474:
2472:
2470:
2469:CDK inhibitor
2466:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2381:
2379:
2377:
2373:
2366:
2362:
2358:
2355:
2352:
2348:
2344:
2340:
2337:
2334:
2330:
2326:
2323:
2320:
2316:
2312:
2309:
2308:
2306:
2304:
2300:
2296:
2293:
2286:
2281:
2279:
2274:
2272:
2267:
2266:
2263:
2256:
2252:
2251:
2247:
2244:
2240:
2239:
2235:
2234:
2230:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2189:
2185:
2181:
2177:
2173:
2169:
2165:
2162:(4): 579–82.
2161:
2157:
2151:
2147:
2143:
2138:
2133:
2129:
2125:
2121:
2116:
2112:
2108:
2104:
2100:
2096:
2092:
2089:(3): 149–58.
2088:
2084:
2078:
2074:
2070:
2066:
2062:
2057:
2053:
2049:
2045:
2043:1-59259-238-4
2039:
2035:
2031:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1985:
1981:
1977:
1972:
1967:
1963:
1959:
1955:
1951:
1947:
1942:
1938:
1934:
1929:
1924:
1920:
1916:
1913:(6): 1120–8.
1912:
1908:
1904:
1899:
1895:
1891:
1886:
1881:
1877:
1873:
1869:
1864:
1860:
1856:
1852:
1848:
1843:
1839:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1798:
1794:
1790:
1785:
1780:
1776:
1772:
1768:
1764:
1760:
1755:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1679:
1675:
1671:
1666:
1661:
1657:
1653:
1649:
1644:
1640:
1636:
1632:
1628:
1623:
1619:
1615:
1611:
1607:
1601:
1597:
1593:
1590:(5): 987–91.
1589:
1585:
1580:
1576:
1572:
1569:(8): 1581–8.
1568:
1564:
1559:
1558:
1553:
1544:
1540:
1536:
1532:
1527:
1522:
1518:
1514:
1511:(6): 957–68.
1510:
1506:
1499:
1496:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1448:
1445:
1440:
1436:
1431:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1391:
1388:
1383:
1379:
1374:
1369:
1365:
1361:
1357:
1350:
1347:
1342:
1338:
1333:
1328:
1324:
1320:
1316:
1312:
1308:
1301:
1298:
1293:
1287:
1285:
1281:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1233:
1230:
1225:
1221:
1215:
1212:
1207:
1203:
1197:
1194:
1190:
1186:
1181:
1179:
1177:
1173:
1169:
1165:
1160:
1158:
1156:
1152:
1145:
1143:
1141:
1137:
1129:
1127:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1093:
1091:
1089:
1086:
1082:
1078:
1074:
1070:
1058:
1053:
1049:
1045:
1042:
1038:
1031:
1029:
1026:
1022:
1018:
1014:
1011:
1007:
1003:
996:
994:
988:
984:
981:
975:
973:
969:
963:
959:
956:
952:
945:
943:
937:
933:
930:
924:
922:
918:
912:
908:
905:
903:RefSeq (mRNA)
901:
894:
893:
888:
884:
881:
875:
874:
869:
865:
862:
860:
856:
849:
848:
843:
839:
836:
830:
829:
824:
820:
817:
815:
811:
804:
803:
798:
794:
791:
785:
784:
779:
775:
772:
770:
766:
763:
760:
758:
755:
751:
748:
744:
740:
733:
729:
724:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
627:
624:
622:
619:
617:
614:
613:
611:
608:
607:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2797:expanding it
2789:chromosome 9
2782:
2677:Prometaphase
2488:
2249:
2237:
2197:
2193:
2159:
2155:
2130:(3): 493–9.
2127:
2123:
2086:
2082:
2067:(5): 443–6.
2064:
2060:
2025:
1995:(4): 392–9.
1992:
1988:
1953:
1949:
1910:
1906:
1875:
1871:
1850:
1846:
1805:
1801:
1766:
1762:
1731:
1727:
1690:
1686:
1655:
1651:
1630:
1626:
1609:
1605:
1587:
1583:
1566:
1562:
1508:
1504:
1498:
1457:
1453:
1447:
1404:
1400:
1390:
1366:(7): 723–9.
1363:
1359:
1349:
1314:
1310:
1300:
1242:
1238:
1232:
1223:
1214:
1205:
1196:
1133:
1130:Interactions
1097:
1084:
1076:
1072:
1068:
1067:
990:
965:
939:
914:
890:
871:
845:
826:
800:
781:
761:
756:
388:
381:
108:External IDs
67:
2698:Cytokinesis
2667:Preprophase
2611:checkpoints
2026:Gene Probes
1090:in humans.
1075:(MTS-2) or
446:skin of hip
426:oral cavity
347:89,229,276
334:89,224,536
246:22,009,305
233:22,002,903
86:Identifiers
2836:Categories
2619:Interphase
2609:Phases and
2292:Cell cycle
1191:, May 2017
1170:, May 2017
1146:References
692:cell cycle
484:left colon
392:(ortholog)
129:HomoloGene
2787:on human
2742:Apoptosis
2692:Telophase
2682:Metaphase
2477:INK4a/ARF
2222:218756624
993:NP_031696
972:NP_511042
968:NP_004927
942:NM_007670
921:NM_004936
917:NM_078487
747:Orthologs
616:cytoplasm
137:GeneCards
2687:Anaphase
2672:Prophase
2295:proteins
2214:32428618
2176:11992549
2146:11874489
2111:19711721
2103:11859969
2073:11695244
2052:11692873
2017:12696178
2009:11283613
1980:11076863
1937:10892805
1894:10574984
1584:Oncogene
1563:Oncogene
1535:16169070
1482:16189514
1439:18185590
1382:25873077
1341:28892048
1311:Oncogene
1187:–
1166:–
1136:interact
1124:TGF beta
1120:cyclin D
1094:Function
1041:Wikidata
726:Sources:
488:calvaria
442:duodenum
2756:Meiosis
2663:Mitosis
2655:M phase
2636:S phase
2503:cip/kip
2061:In Vivo
1928:2144649
1859:9230210
1838:1040022
1830:9163429
1810:Bibcode
1793:9111314
1750:9042862
1715:8153634
1695:Bibcode
1687:Science
1674:8001816
1639:7987828
1618:7882351
1596:7675459
1575:7478582
1543:8235923
1490:4427026
1462:Bibcode
1430:2743558
1409:Bibcode
1332:5759028
1275:4268054
1267:8078588
1247:Bibcode
1189:Ensembl
1168:Ensembl
1081:protein
859:UniProt
814:Ensembl
753:Species
732:QuickGO
626:nucleus
621:cytosol
480:jejunum
367:pattern
93:Aliases
2595:Cullin
2481:p14arf
2303:Cyclin
2250:CDKN2B
2238:CDKN2B
2220:
2212:
2182:
2174:
2144:
2109:
2101:
2071:
2050:
2040:
2015:
2007:
1978:
1971:310948
1968:
1935:
1925:
1892:
1857:
1836:
1828:
1802:Nature
1791:
1784:232094
1781:
1748:
1713:
1672:
1637:
1616:
1594:
1573:
1541:
1533:
1488:
1480:
1454:Nature
1437:
1427:
1401:Nature
1380:
1339:
1329:
1273:
1265:
1239:Nature
1104:CDKN2A
1085:CDKN2B
1027:search
1025:PubMed
892:P55271
873:P42772
769:Entrez
538:BioGPS
434:rectum
225:9p21.3
141:CDKN2B
125:104737
117:600431
100:CDKN2B
22:CDKN2B
2791:is a
2751:phase
2645:phase
2631:phase
2570:Cdc42
2565:Cdc25
2553:Other
2335:, B3)
2218:S2CID
2184:81974
2180:S2CID
2107:S2CID
2013:S2CID
1834:S2CID
1539:S2CID
1486:S2CID
1271:S2CID
1138:with
1102:gene
1079:is a
802:12579
762:Mouse
757:Human
728:Amigo
492:ileum
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:55859
2793:stub
2785:gene
2599:CUL7
2560:Cdc2
2210:PMID
2172:PMID
2142:PMID
2099:PMID
2069:PMID
2048:PMID
2038:ISBN
2005:PMID
1976:PMID
1933:PMID
1890:PMID
1855:PMID
1826:PMID
1789:PMID
1746:PMID
1711:PMID
1670:PMID
1635:PMID
1614:PMID
1592:PMID
1571:PMID
1531:PMID
1505:Cell
1478:PMID
1435:PMID
1378:PMID
1337:PMID
1263:PMID
1116:CDK6
1112:CDK4
1088:gene
783:1030
450:gums
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:1D9S
51:RCSB
48:PDBe
2590:Wee
2580:E2F
2544:p73
2539:p63
2534:p53
2515:p57
2511:p27
2507:p21
2497:p19
2493:p18
2489:p15
2485:p16
2439:11B
2434:11A
2376:CDK
2202:doi
2164:doi
2132:doi
2128:118
2091:doi
2030:doi
1997:doi
1966:PMC
1958:doi
1923:PMC
1915:doi
1880:doi
1876:274
1818:doi
1806:387
1779:PMC
1771:doi
1736:doi
1703:doi
1691:264
1660:doi
1521:hdl
1513:doi
1509:122
1470:doi
1458:437
1425:PMC
1417:doi
1405:451
1368:doi
1327:PMC
1319:doi
1255:doi
1243:371
1114:or
1077:p15
343:End
242:End
145:OMA
121:MGI
41:PDB
2838::
2513:,
2509:,
2495:,
2491:,
2487:,
2454:14
2449:13
2444:12
2429:10
2365:E2
2363:,
2361:E1
2351:D3
2349:,
2347:D2
2345:,
2343:D1
2333:B2
2331:,
2329:B1
2319:A2
2317:,
2315:A1
2216:.
2208:.
2198:37
2196:.
2178:.
2170:.
2160:99
2158:.
2140:.
2126:.
2122:.
2105:.
2097:.
2087:55
2085:.
2065:15
2063:.
2046:.
2036:.
2011:.
2003:.
1991:.
1974:.
1964:.
1954:10
1952:.
1948:.
1931:.
1921:.
1909:.
1905:.
1888:.
1874:.
1870:.
1851:57
1849:.
1832:.
1824:.
1816:.
1804:.
1787:.
1777:.
1767:17
1765:.
1761:.
1744:.
1732:11
1730:.
1726:.
1709:.
1701:.
1689:.
1685:.
1668:.
1654:.
1650:.
1631:54
1629:.
1610:55
1608:.
1588:11
1586:.
1567:11
1565:.
1537:.
1529:.
1519:.
1507:.
1484:.
1476:.
1468:.
1456:.
1433:.
1423:.
1415:.
1403:.
1399:.
1376:.
1362:.
1358:.
1335:.
1325:.
1315:37
1313:.
1309:.
1283:^
1269:.
1261:.
1253:.
1241:.
1222:.
1204:.
1175:^
1154:^
1142:.
730:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
2824:e
2817:t
2810:v
2799:.
2749:0
2747:G
2694:)
2665:(
2643:2
2641:G
2629:1
2627:G
2601:)
2597:(
2517:)
2505:(
2499:)
2483:/
2479:(
2424:9
2419:8
2414:7
2409:6
2404:5
2399:4
2394:3
2389:2
2384:1
2367:)
2359:(
2357:E
2353:)
2341:(
2339:D
2327:(
2325:B
2321:)
2313:(
2311:A
2284:e
2277:t
2270:v
2257:.
2245:.
2224:.
2204::
2186:.
2166::
2148:.
2134::
2113:.
2093::
2075:.
2054:.
2032::
2019:.
1999::
1993:3
1982:.
1960::
1939:.
1917::
1911:9
1896:.
1882::
1861:.
1840:.
1820::
1812::
1795:.
1773::
1752:.
1738::
1717:.
1705::
1697::
1676:.
1662::
1656:8
1641:.
1620:.
1598:.
1577:.
1545:.
1523::
1515::
1492:.
1472::
1464::
1441:.
1419::
1411::
1384:.
1370::
1364:5
1343:.
1321::
1294:.
1277:.
1257::
1249::
1226:.
1208:.
267:)
164:)
147::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
