320:
297:
1390:, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to
194:
219:
2849:
2834:
2819:
571:
578:
2804:
31:
326:
225:
57:
1772:
Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC (January 2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction".
2848:
1810:"The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner"
2833:
2818:
333:
232:
1398:
2521:
Kesavapany S, Lau KF, McLoughlin DM, et al. (2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction".
1386:(CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by
1101:
155:
1082:
126:, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
2036:
Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway".
1573:
Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E (October 1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5".
2803:
2877:
2783:
2289:
Patrick GN, Zukerberg L, Nikolic M, et al. (2000). "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration".
1555:
1537:
319:
2743:
1301:
2552:"Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation"
2061:
Studzinski GP, Harrison JS (2003). "The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells".
1900:"Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation"
1308:
296:
1627:
1524:
1503:
2178:"Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality"
218:
193:
2749:
1520:
54:
1499:
135:
2488:"Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2"
1733:"Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2"
1410:
332:
231:
325:
224:
2776:
1446:
1383:
1146:
143:
1127:
1391:
207:
2406:
Lee MS, Kwon YT, Li M, et al. (2000). "Neurotoxicity induces cleavage of p35 to p25 by calpain".
2769:
2415:
2368:
1582:
122:
2755:
2326:
Ching YP, Qi Z, Wang JH (2000). "Cloning of three novel neuronal Cdk5 activator binding proteins".
2857:: STRUCTURAL MECHANISM FOR THE INHIBITION OF CD5-P25 FROM THE ROSCOVITINE, ALOISINE AND INDIRUBIN.
2657:"The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity"
2439:
2394:
2314:
2207:
2129:
2086:
1982:"The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity"
1672:
1606:
167:
1284:
1263:
1237:
1216:
570:
2723:
2688:
2643:
2608:
2573:
2538:
2509:
2474:
2431:
2386:
2343:
2306:
2277:
2242:
2199:
2164:
2121:
2078:
2049:
2013:
1962:
1921:
1880:
1839:
1790:
1754:
1713:
1664:
1598:
115:
47:
2842:: STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.
2827:: STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.
2713:
2678:
2668:
2633:
2598:
2563:
2530:
2499:
2464:
2423:
2376:
2335:
2298:
2267:
2232:
2189:
2154:
2111:
2070:
2041:
2003:
1993:
1952:
1911:
1870:
1829:
1821:
1782:
1744:
1703:
1654:
1590:
1417:
577:
412:
343:
287:
242:
163:
387:
2419:
2372:
1586:
30:
1834:
1825:
1809:
2603:
2586:
2453:"Identification of a common protein association region in the neuronal Cdk5 activator"
2381:
2356:
2339:
2194:
2177:
1957:
1940:
1859:"Identification of a common protein association region in the neuronal Cdk5 activator"
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
2871:
2683:
2534:
2443:
2256:"Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18"
2116:
2099:
2008:
1786:
1659:
1642:
606:
2398:
2211:
2133:
2090:
1676:
2318:
1610:
1428:
405:
184:
147:
2702:"Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29"
1939:
Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A (September 2001).
171:
2074:
1560:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1542:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1452:
1422:
1007:
positive regulation of cyclin-dependent protein serine/threonine kinase activity
488:
2568:
2551:
2045:
1916:
1899:
1731:
Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De
Camilli P (March 2001).
304:
201:
151:
2221:"Identification of functional domains in the neuronal Cdk5 activator protein"
2159:
2142:
2622:"Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology"
1046:
548:
426:
371:
358:
270:
257:
159:
2727:
2718:
2701:
2692:
2673:
2656:
2647:
2638:
2621:
2612:
2577:
2542:
2513:
2504:
2487:
2478:
2469:
2452:
2435:
2390:
2347:
2310:
2272:
2255:
2237:
2220:
2082:
2053:
2017:
1998:
1981:
1966:
1925:
1884:
1875:
1858:
1843:
1794:
1758:
1749:
1732:
1717:
1708:
1691:
1668:
1628:"Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)"
2281:
2246:
2203:
2168:
2125:
1602:
1348:
1343:
1475:
1470:
1465:
1440:
1382:
The protein encoded by this gene (p35) is a neuron-specific activator of
1332:
1191:
1172:
1643:"Novel MITF targets identified using a two-step DNA microarray strategy"
2143:"An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator"
1808:
Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002).
1387:
1158:
1113:
837:
regulation of cyclin-dependent protein serine/threonine kinase activity
92:
88:
84:
80:
76:
2427:
1594:
1434:
1364:
1316:
1068:
2357:"Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase"
1692:"Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35"
640:
cyclin-dependent protein serine/threonine kinase activator activity
2302:
1980:
Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (March 2002).
1857:
Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH (October 2000).
1031:
1027:
1397:
In melanocytic cells CDK5R1 gene expression may be regulated by
1371:
139:
2765:
882:
positive regulation of protein serine/threonine kinase activity
586:
2761:
2254:
Fletcher AI, Shuang R, Giovannucci DR, et al. (1999).
1690:
Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (August 2002).
832:
G protein-coupled acetylcholine receptor signaling pathway
2812:: STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX
2587:"Structure and regulation of the CDK5-p25(nck5a) complex"
1941:"Structure and regulation of the CDK5-p25(nck5a) complex"
395:
1641:
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008).
982:
regulation of signal transduction by p53 class mediator
2098:
Takahashi M, Tomizawa K, Sato K, et al. (1995).
560:
2486:
Floyd SR, Porro EB, Slepnev VI, et al. (2001).
972:
positive regulation of protein targeting to membrane
2585:Tarricone C, Dhavan R, Peng J, et al. (2001).
1277:
1256:
1230:
1209:
927:
negative regulation of transcription, DNA-templated
867:
regulation of microtubule cytoskeleton organization
1516:
1514:
1512:
1495:
1493:
1491:
997:embryo development ending in birth or egg hatching
660:protein serine/threonine kinase activator activity
1002:positive regulation of microtubule polymerization
342:
241:
2176:Chae T, Kwon YT, Bronson R, et al. (1997).
937:cerebral cortex radially oriented cell migration
897:ionotropic glutamate receptor signaling pathway
887:positive regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
2451:Wang X, Ching YP, Lam WH, et al. (2000).
2355:Kwon YT, Gupta A, Zhou Y, et al. (2000).
2100:"A novel tau-tubulin kinase from bovine brain"
1521:GRCm38: Ensembl release 89: ENSMUSG00000048895
822:positive regulation of protein kinase activity
2777:
2141:Tang D, Yeung J, Lee KY, et al. (1995).
842:regulation of actin cytoskeleton organization
8:
1500:GRCh38: Ensembl release 89: ENSG00000176749
957:regulation of dendritic spine morphogenesis
2784:
2770:
2762:
1042:
602:
383:
282:
179:
65:
2717:
2682:
2672:
2637:
2602:
2567:
2503:
2468:
2380:
2271:
2236:
2193:
2158:
2115:
2007:
1997:
1956:
1915:
1874:
1833:
1748:
1707:
1658:
2655:Qu D, Li Q, Lim HY, et al. (2002).
2620:Rashid T, Banerjee M, Nikolic M (2002).
1622:
1620:
731:intracellular membrane-bounded organelle
2799:
1487:
987:serine phosphorylation of STAT protein
20:
1361:Cyclin-dependent kinase 5 activator 1
1017:activation of protein kinase activity
992:microtubule cytoskeleton organization
952:negative regulation of axon extension
675:ionotropic glutamate receptor binding
347:
308:
303:
246:
205:
200:
7:
1012:regulation of synaptic vesicle cycle
827:regulation of neuron differentiation
1898:Chen F, Studzinski GP (June 2001).
967:superior olivary nucleus maturation
1826:10.1523/JNEUROSCI.22-18-07879.2002
1274:
1253:
1227:
1206:
1182:
1163:
1137:
1118:
1092:
1073:
922:peptidyl-threonine phosphorylation
902:layer formation in cerebral cortex
565:
483:
421:
400:
14:
2219:Poon RY, Lew J, Hunter T (1997).
1367:that in humans is encoded by the
857:ephrin receptor signaling pathway
695:protein kinase activator activity
2847:
2832:
2817:
2802:
2535:10.1046/j.1460-9568.2001.01376.x
1787:10.1046/j.1460-9568.2001.01376.x
1660:10.1111/j.1755-148X.2008.00505.x
576:
569:
331:
324:
318:
295:
230:
223:
217:
192:
29:
907:peptidyl-serine phosphorylation
771:perinuclear region of cytoplasm
2550:Chen F, Studzinski GP (2001).
587:More reference expression data
549:More reference expression data
441:Region I of hippocampus proper
1:
2604:10.1016/S1097-2765(01)00343-4
2382:10.1016/S0960-9822(00)00411-5
2340:10.1016/S0378-1119(99)00499-0
2195:10.1016/S0896-6273(01)80044-1
1958:10.1016/S1097-2765(01)00343-4
932:neuron projection development
917:cell population proliferation
316:
215:
2878:Genes on human chromosome 17
2117:10.1016/0014-5793(95)00955-9
962:regulation of macroautophagy
2075:10.1080/1042819021000030009
2894:
2754:gene details page in the
2700:Patzke H, Tsai LH (2002).
527:lateral geniculate nucleus
507:medial ganglionic eminence
2797:
2569:10.1182/blood.V97.12.3763
2046:10.1080/13550280290167885
1917:10.1182/blood.V97.12.3763
1647:Pigment Cell Melanoma Res
1556:"Mouse PubMed Reference:"
1538:"Human PubMed Reference:"
1447:Cyclin-dependent kinase 5
1409:CDK5R1 has been shown to
1384:cyclin-dependent kinase 5
1347:
1342:
1338:
1331:
1315:
1296:
1281:
1260:
1249:
1234:
1213:
1202:
1189:
1185:
1170:
1166:
1157:
1144:
1140:
1125:
1121:
1112:
1099:
1095:
1080:
1076:
1067:
1052:
1045:
1041:
1025:
862:neuron cell-cell adhesion
605:
601:
584:
568:
559:
546:
519:medial geniculate nucleus
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
133:
130:
120:
113:
108:
73:
68:
51:
46:
41:
37:
28:
23:
2160:10.1074/jbc.270.45.26897
1309:Chr 11: 80.37 – 80.37 Mb
1302:Chr 17: 32.49 – 32.49 Mb
766:protein kinase 5 complex
499:Rostral migratory stream
2040:. 8 Suppl 2 (2): 91–6.
947:hippocampus development
630:ephrin receptor binding
620:protein kinase activity
2719:10.1074/jbc.M109645200
2674:10.1074/jbc.M107270200
2639:10.1074/jbc.M105599200
2505:10.1074/jbc.M008932200
2470:10.1074/jbc.M004358200
2273:10.1074/jbc.274.7.4027
2238:10.1074/jbc.272.9.5703
1999:10.1074/jbc.M107270200
1876:10.1074/jbc.M004358200
1750:10.1074/jbc.M008932200
1709:10.1074/jbc.M201161200
912:neuron differentiation
877:cerebellum development
741:neuromuscular junction
690:actin filament binding
655:protein kinase binding
531:lateral septal nucleus
453:superior frontal gyrus
349:11 B5|11 47.94 cM
2684:10536/DRO/DU:30101408
2009:10536/DRO/DU:30101408
680:alpha-tubulin binding
503:medial dorsal nucleus
310:Chromosome 11 (mouse)
208:Chromosome 17 (human)
2748:genome location and
942:axonal fasciculation
726:postsynaptic density
685:beta-tubulin binding
457:orbitofrontal cortex
69:List of PDB id codes
42:Available structures
2756:UCSC Genome Browser
2420:2000Natur.405..360L
2373:2000CBio...10..363K
1587:1994Natur.371..419T
1392:Alzheimer's disease
625:calcium ion binding
437:ganglionic eminence
1147:ENSMUSG00000048895
847:embryo development
815:Biological process
756:neuronal cell body
704:Cellular component
613:Molecular function
511:olfactory tubercle
172:CDK5R1 - orthologs
2865:
2864:
2153:(45): 26897–903.
1358:
1357:
1354:
1353:
1327:
1326:
1292:
1291:
1271:
1270:
1245:
1244:
1224:
1223:
1198:
1197:
1179:
1178:
1153:
1152:
1134:
1133:
1108:
1107:
1089:
1088:
1037:
1036:
892:brain development
801:neuron projection
776:contractile fiber
597:
596:
593:
592:
555:
554:
542:
541:
523:prefrontal cortex
515:nucleus accumbens
480:
479:
473:entorhinal cortex
469:postcentral gyrus
378:
377:
277:
276:
104:
103:
100:
99:
52:Ortholog search:
2885:
2851:
2836:
2821:
2806:
2786:
2779:
2772:
2763:
2731:
2721:
2696:
2686:
2676:
2651:
2641:
2632:(52): 49043–52.
2616:
2606:
2581:
2571:
2546:
2523:Eur. J. Neurosci
2517:
2507:
2482:
2472:
2447:
2428:10.1038/35012636
2402:
2384:
2351:
2322:
2297:(6762): 615–22.
2285:
2275:
2250:
2240:
2215:
2197:
2172:
2162:
2137:
2119:
2094:
2057:
2022:
2021:
2011:
2001:
1977:
1971:
1970:
1960:
1936:
1930:
1929:
1919:
1895:
1889:
1888:
1878:
1854:
1848:
1847:
1837:
1805:
1799:
1798:
1775:Eur. J. Neurosci
1769:
1763:
1762:
1752:
1728:
1722:
1721:
1711:
1702:(35): 31988–93.
1687:
1681:
1680:
1662:
1638:
1632:
1631:
1624:
1615:
1614:
1595:10.1038/371419a0
1581:(6496): 419–23.
1570:
1564:
1563:
1552:
1546:
1545:
1534:
1528:
1518:
1507:
1497:
1418:Actinin, alpha 1
1340:
1339:
1311:
1304:
1287:
1275:
1266:
1254:
1250:RefSeq (protein)
1240:
1228:
1219:
1207:
1183:
1164:
1138:
1119:
1093:
1074:
1043:
872:neuron migration
852:rhythmic process
665:protease binding
635:cadherin binding
603:
589:
580:
573:
566:
551:
491:
489:Top expressed in
484:
449:ventricular zone
445:Brodmann area 23
429:
427:Top expressed in
422:
401:
384:
374:
361:
350:
335:
328:
322:
311:
299:
283:
273:
260:
249:
234:
227:
221:
210:
196:
180:
174:
125:
118:
95:
66:
60:
39:
38:
33:
21:
2893:
2892:
2888:
2887:
2886:
2884:
2883:
2882:
2868:
2867:
2866:
2861:
2858:
2852:
2843:
2837:
2828:
2822:
2813:
2807:
2793:
2790:
2739:
2734:
2712:(10): 8054–60.
2699:
2654:
2619:
2584:
2549:
2520:
2498:(11): 8104–10.
2485:
2463:(41): 31763–9.
2450:
2414:(6784): 360–4.
2405:
2354:
2334:(1–2): 285–94.
2325:
2288:
2253:
2218:
2175:
2140:
2097:
2060:
2035:
2031:
2029:Further reading
2026:
2025:
1979:
1978:
1974:
1938:
1937:
1933:
1897:
1896:
1892:
1869:(41): 31763–9.
1856:
1855:
1851:
1820:(18): 7879–91.
1807:
1806:
1802:
1771:
1770:
1766:
1743:(11): 8104–10.
1730:
1729:
1725:
1689:
1688:
1684:
1640:
1639:
1635:
1626:
1625:
1618:
1572:
1571:
1567:
1554:
1553:
1549:
1536:
1535:
1531:
1519:
1510:
1498:
1489:
1484:
1462:
1407:
1380:
1349:View/Edit Mouse
1344:View/Edit Human
1307:
1300:
1297:Location (UCSC)
1283:
1262:
1236:
1215:
1128:ENSG00000176749
1021:
810:
791:plasma membrane
746:dendritic spine
699:
650:protein binding
645:kinase activity
585:
575:
574:
547:
538:
533:
529:
525:
521:
517:
513:
509:
505:
501:
487:
476:
471:
467:
463:
461:Brodmann area 9
459:
455:
451:
447:
443:
439:
425:
369:
356:
348:
338:
337:
336:
329:
309:
286:Gene location (
268:
255:
247:
237:
236:
235:
228:
206:
183:Gene location (
134:
121:
114:
75:
53:
17:
12:
11:
5:
2891:
2889:
2881:
2880:
2870:
2869:
2863:
2862:
2860:
2859:
2853:
2846:
2844:
2838:
2831:
2829:
2823:
2816:
2814:
2808:
2801:
2798:
2795:
2794:
2791:
2789:
2788:
2781:
2774:
2766:
2760:
2759:
2738:
2737:External links
2735:
2733:
2732:
2697:
2667:(9): 7324–32.
2652:
2617:
2582:
2562:(12): 3763–7.
2547:
2518:
2483:
2448:
2403:
2352:
2323:
2286:
2266:(7): 4027–35.
2251:
2216:
2173:
2138:
2095:
2063:Leuk. Lymphoma
2058:
2032:
2030:
2027:
2024:
2023:
1992:(9): 7324–32.
1972:
1931:
1910:(12): 3763–7.
1890:
1849:
1800:
1764:
1723:
1682:
1633:
1616:
1565:
1547:
1529:
1508:
1486:
1485:
1483:
1480:
1479:
1478:
1473:
1468:
1461:
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1450:
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1406:
1403:
1379:
1376:
1356:
1355:
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1351:
1346:
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1329:
1328:
1325:
1324:
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1320:
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1196:
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1187:
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1180:
1177:
1176:
1168:
1167:
1161:
1155:
1154:
1151:
1150:
1142:
1141:
1135:
1132:
1131:
1123:
1122:
1116:
1110:
1109:
1106:
1105:
1097:
1096:
1090:
1087:
1086:
1078:
1077:
1071:
1065:
1064:
1059:
1054:
1050:
1049:
1039:
1038:
1035:
1034:
1023:
1022:
1020:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
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954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
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884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
818:
816:
812:
811:
809:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
707:
705:
701:
700:
698:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
616:
614:
610:
609:
599:
598:
595:
594:
591:
590:
582:
581:
563:
557:
556:
553:
552:
544:
543:
540:
539:
537:
536:
532:
528:
524:
520:
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512:
508:
504:
500:
496:
493:
492:
481:
478:
477:
475:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
431:
430:
418:
417:
409:
398:
392:
391:
388:RNA expression
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
307:
301:
300:
292:
291:
279:
278:
275:
274:
266:
262:
261:
253:
250:
245:
239:
238:
229:
222:
216:
212:
211:
204:
198:
197:
189:
188:
176:
175:
132:
128:
127:
119:
111:
110:
106:
105:
102:
101:
98:
97:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2890:
2879:
2876:
2875:
2873:
2856:
2850:
2845:
2841:
2835:
2830:
2826:
2820:
2815:
2811:
2805:
2800:
2796:
2787:
2782:
2780:
2775:
2773:
2768:
2767:
2764:
2757:
2753:
2752:
2747:
2746:
2741:
2740:
2736:
2729:
2725:
2720:
2715:
2711:
2707:
2706:J. Biol. Chem
2703:
2698:
2694:
2690:
2685:
2680:
2675:
2670:
2666:
2662:
2661:J. Biol. Chem
2658:
2653:
2649:
2645:
2640:
2635:
2631:
2627:
2626:J. Biol. Chem
2623:
2618:
2614:
2610:
2605:
2600:
2597:(3): 657–69.
2596:
2592:
2588:
2583:
2579:
2575:
2570:
2565:
2561:
2557:
2553:
2548:
2544:
2540:
2536:
2532:
2528:
2524:
2519:
2515:
2511:
2506:
2501:
2497:
2493:
2492:J. Biol. Chem
2489:
2484:
2480:
2476:
2471:
2466:
2462:
2458:
2457:J. Biol. Chem
2454:
2449:
2445:
2441:
2437:
2433:
2429:
2425:
2421:
2417:
2413:
2409:
2404:
2400:
2396:
2392:
2388:
2383:
2378:
2374:
2370:
2367:(7): 363–72.
2366:
2362:
2358:
2353:
2349:
2345:
2341:
2337:
2333:
2329:
2324:
2320:
2316:
2312:
2308:
2304:
2303:10.1038/45159
2300:
2296:
2292:
2287:
2283:
2279:
2274:
2269:
2265:
2261:
2260:J. Biol. Chem
2257:
2252:
2248:
2244:
2239:
2234:
2231:(9): 5703–8.
2230:
2226:
2225:J. Biol. Chem
2222:
2217:
2213:
2209:
2205:
2201:
2196:
2191:
2187:
2183:
2179:
2174:
2170:
2166:
2161:
2156:
2152:
2148:
2147:J. Biol. Chem
2144:
2139:
2135:
2131:
2127:
2123:
2118:
2113:
2109:
2105:
2101:
2096:
2092:
2088:
2084:
2080:
2076:
2072:
2069:(2): 235–40.
2068:
2064:
2059:
2055:
2051:
2047:
2043:
2039:
2038:J. Neurovirol
2034:
2033:
2028:
2019:
2015:
2010:
2005:
2000:
1995:
1991:
1987:
1986:J. Biol. Chem
1983:
1976:
1973:
1968:
1964:
1959:
1954:
1951:(3): 657–69.
1950:
1946:
1942:
1935:
1932:
1927:
1923:
1918:
1913:
1909:
1905:
1901:
1894:
1891:
1886:
1882:
1877:
1872:
1868:
1864:
1863:J. Biol. Chem
1860:
1853:
1850:
1845:
1841:
1836:
1831:
1827:
1823:
1819:
1815:
1811:
1804:
1801:
1796:
1792:
1788:
1784:
1780:
1776:
1768:
1765:
1760:
1756:
1751:
1746:
1742:
1738:
1737:J. Biol. Chem
1734:
1727:
1724:
1719:
1715:
1710:
1705:
1701:
1697:
1696:J. Biol. Chem
1693:
1686:
1683:
1678:
1674:
1670:
1666:
1661:
1656:
1653:(6): 665–76.
1652:
1648:
1644:
1637:
1634:
1629:
1623:
1621:
1617:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1569:
1566:
1561:
1557:
1551:
1548:
1543:
1539:
1533:
1530:
1526:
1522:
1517:
1515:
1513:
1509:
1505:
1501:
1496:
1494:
1492:
1488:
1481:
1477:
1474:
1472:
1469:
1467:
1464:
1463:
1459:
1454:
1451:
1448:
1445:
1442:
1439:
1436:
1433:
1430:
1427:
1424:
1421:
1419:
1416:
1415:
1414:
1412:
1404:
1402:
1400:
1395:
1393:
1389:
1385:
1377:
1375:
1373:
1370:
1366:
1362:
1350:
1345:
1341:
1337:
1334:
1330:
1323:
1321:
1318:
1314:
1310:
1306:
1303:
1299:
1295:
1288:
1286:
1280:
1276:
1273:
1267:
1265:
1259:
1255:
1252:
1248:
1241:
1239:
1233:
1229:
1226:
1220:
1218:
1212:
1208:
1205:
1203:RefSeq (mRNA)
1201:
1194:
1193:
1188:
1184:
1181:
1175:
1174:
1169:
1165:
1162:
1160:
1156:
1149:
1148:
1143:
1139:
1136:
1130:
1129:
1124:
1120:
1117:
1115:
1111:
1104:
1103:
1098:
1094:
1091:
1085:
1084:
1079:
1075:
1072:
1070:
1066:
1063:
1060:
1058:
1055:
1051:
1048:
1044:
1040:
1033:
1029:
1024:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
977:axon guidance
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
819:
817:
814:
813:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
708:
706:
703:
702:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
670:actin binding
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
617:
615:
612:
611:
608:
607:Gene ontology
604:
600:
588:
583:
579:
572:
567:
564:
562:
558:
550:
545:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
472:
468:
465:parietal lobe
464:
460:
456:
452:
448:
444:
440:
436:
435:
432:
428:
423:
420:
419:
416:
414:
410:
408:
407:
403:
402:
399:
397:
393:
389:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
306:
302:
298:
293:
289:
284:
280:
272:
267:
263:
259:
254:
244:
240:
233:
226:
220:
213:
209:
203:
199:
195:
190:
186:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
129:
124:
117:
112:
107:
96:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2854:
2839:
2824:
2809:
2750:
2744:
2709:
2705:
2664:
2660:
2629:
2625:
2594:
2590:
2559:
2555:
2529:(2): 241–7.
2526:
2522:
2495:
2491:
2460:
2456:
2411:
2407:
2364:
2360:
2331:
2327:
2294:
2290:
2263:
2259:
2228:
2224:
2188:(1): 29–42.
2185:
2181:
2150:
2146:
2110:(1): 59–64.
2107:
2103:
2066:
2062:
2037:
1989:
1985:
1975:
1948:
1944:
1934:
1907:
1903:
1893:
1866:
1862:
1852:
1817:
1813:
1803:
1781:(2): 241–7.
1778:
1774:
1767:
1740:
1736:
1726:
1699:
1695:
1685:
1650:
1646:
1636:
1578:
1574:
1568:
1559:
1550:
1541:
1532:
1429:Beta-catenin
1408:
1405:Interactions
1396:
1381:
1368:
1360:
1359:
1282:
1261:
1235:
1214:
1190:
1171:
1145:
1126:
1100:
1081:
1061:
1056:
411:
404:
131:External IDs
74:
18:
2792:PDB gallery
1814:J. Neurosci
1453:Protein SET
1423:Amphiphysin
796:microtubule
786:nucleoplasm
736:growth cone
370:80,372,010
357:80,367,849
269:32,491,253
256:32,486,993
109:Identifiers
2361:Curr. Biol
1527:, May 2017
1506:, May 2017
1482:References
806:presynapse
415:(ortholog)
152:HomoloGene
2591:Mol. Cell
2444:205006589
2104:FEBS Lett
1945:Mol. Cell
1285:NP_034001
1264:NP_003876
1238:NM_009871
1217:NM_003885
1047:Orthologs
711:cytoplasm
535:subiculum
160:GeneCards
2872:Category
2728:11784720
2693:11741927
2648:11604394
2613:11583627
2578:11389014
2543:11168528
2514:11113134
2479:10915792
2436:10830966
2399:16438320
2391:10753743
2348:10721722
2311:10604467
2212:18685470
2134:42295269
2091:30242995
2083:12688339
2054:12491158
2018:11741927
1967:11583627
1926:11389014
1885:10915792
1844:12223541
1795:11168528
1759:11113134
1718:12084709
1677:24698373
1669:19067971
1523:–
1502:–
1476:CDK5RAP3
1471:CDK5RAP2
1466:CDK5RAP1
1460:See also
1441:CDK5RAP2
1411:interact
1378:Function
1333:Wikidata
1026:Sources:
761:dendrite
721:membrane
2416:Bibcode
2369:Bibcode
2319:4414281
2282:9933594
2247:9038181
2204:9010203
2169:7592934
2126:7556643
1835:6758084
1611:4267944
1603:8090221
1583:Bibcode
1525:Ensembl
1504:Ensembl
1388:calpain
1159:UniProt
1114:Ensembl
1053:Species
1032:QuickGO
781:nucleus
716:cytosol
390:pattern
248:17q11.2
116:Aliases
2751:CDK5R1
2745:CDK5R1
2742:Human
2726:
2691:
2646:
2611:
2576:
2541:
2512:
2477:
2442:
2434:
2408:Nature
2397:
2389:
2346:
2317:
2309:
2291:Nature
2280:
2245:
2210:
2202:
2182:Neuron
2167:
2132:
2124:
2089:
2081:
2052:
2016:
1965:
1924:
1883:
1842:
1832:
1793:
1757:
1716:
1675:
1667:
1609:
1601:
1575:Nature
1435:CAMK2A
1413:with:
1369:CDK5R1
1365:enzyme
1363:is an
1319:search
1317:PubMed
1192:P61809
1173:Q15078
1069:Entrez
561:BioGPS
164:CDK5R1
148:101764
140:603460
123:CDK5R1
24:CDK5R1
2556:Blood
2440:S2CID
2395:S2CID
2315:S2CID
2208:S2CID
2130:S2CID
2087:S2CID
1904:Blood
1673:S2CID
1607:S2CID
1102:12569
1062:Mouse
1057:Human
1028:Amigo
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
185:Human
156:31200
2855:1unl
2840:1unh
2825:1ung
2810:1h4l
2724:PMID
2689:PMID
2644:PMID
2609:PMID
2574:PMID
2539:PMID
2510:PMID
2475:PMID
2432:PMID
2387:PMID
2344:PMID
2328:Gene
2307:PMID
2278:PMID
2243:PMID
2200:PMID
2165:PMID
2122:PMID
2079:PMID
2050:PMID
2014:PMID
1963:PMID
1922:PMID
1881:PMID
1840:PMID
1791:PMID
1755:PMID
1714:PMID
1665:PMID
1599:PMID
1399:MITF
1372:gene
1083:8851
751:axon
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
136:OMIM
93:3O0G
89:1UNL
85:1UNH
81:1UNG
77:1H4L
58:RCSB
55:PDBe
2714:doi
2710:277
2679:hdl
2669:doi
2665:277
2634:doi
2630:276
2599:doi
2564:doi
2531:doi
2500:doi
2496:276
2465:doi
2461:275
2424:doi
2412:405
2377:doi
2336:doi
2332:242
2299:doi
2295:402
2268:doi
2264:274
2233:doi
2229:272
2190:doi
2155:doi
2151:270
2112:doi
2108:372
2071:doi
2042:doi
2004:hdl
1994:doi
1990:277
1953:doi
1912:doi
1871:doi
1867:275
1830:PMC
1822:doi
1783:doi
1745:doi
1741:276
1704:doi
1700:277
1655:doi
1591:doi
1579:371
366:End
265:End
168:OMA
144:MGI
48:PDB
2874::
2722:.
2708:.
2704:.
2687:.
2677:.
2663:.
2659:.
2642:.
2628:.
2624:.
2607:.
2593:.
2589:.
2572:.
2560:97
2558:.
2554:.
2537:.
2527:13
2525:.
2508:.
2494:.
2490:.
2473:.
2459:.
2455:.
2438:.
2430:.
2422:.
2410:.
2393:.
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