253:
230:
127:
152:
511:
504:
259:
158:
1894:
1008:
This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for
1282:
Lundström A, Serre G, Haftek M, Egelrud T (1995). "Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation".
1025:
1322:"Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation"
266:
165:
1611:
Levy-Nissenbaum E, Betz RC, Frydman M, et al. (2003). "Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin".
724:
1720:"A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups"
88:
705:
1125:"Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes"
1843:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1432:"Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation"
1963:
1105:
1939:
1087:
1958:
252:
1500:
Hui J, Oka A, Tamiya G, et al. (2003). "Corneodesmosin DNA polymorphisms in MHC haplotypes and
Japanese patients with psoriasis".
939:
932:
229:
1529:
Orrù S, Giuressi E, Casula M, et al. (2003). "Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN)".
1796:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1401:
Guerrin M, Vincent C, Simon M, et al. (2001). "Identification of six novel polymorphisms in the human corneodesmosin gene".
1226:
1074:
1053:
1357:"Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris"
1245:
Toribio J, Quiñones PA (1975). "Hereditary hypotrichosis simplex of the scalp. Evidence for autosomal dominant inheritance".
1070:
1685:"Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7"
151:
126:
1356:
1049:
68:
265:
164:
1932:
258:
157:
769:
76:
750:
1467:"Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties"
1755:"Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice"
1925:
1805:
1571:
1177:
140:
1013:. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
55:
1166:"Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation"
915:
911:
864:
860:
1829:
1636:
1308:
1270:
100:
1650:"Homo-oligomerization of human corneodesmosin is mediated by its N-terminal glycine loop domain"
1560:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
890:
839:
1872:
1821:
1784:
1741:
1706:
1671:
1628:
1599:
1546:
1517:
1488:
1453:
1418:
1389:
1343:
1300:
1262:
1205:
1146:
48:
1909:
1968:
1862:
1854:
1813:
1774:
1766:
1731:
1696:
1661:
1620:
1589:
1579:
1538:
1509:
1478:
1443:
1410:
1379:
1371:
1333:
1292:
1254:
1195:
1185:
1136:
510:
345:
276:
220:
175:
503:
320:
96:
1414:
1809:
1575:
1181:
1867:
1842:
1258:
1779:
1754:
1594:
1559:
1542:
1513:
1375:
639:
634:
629:
624:
619:
614:
609:
604:
588:
583:
578:
573:
568:
552:
1952:
1701:
1684:
1666:
1649:
1200:
1165:
539:
1640:
1274:
80:
1905:
1833:
1010:
338:
117:
1312:
104:
1110:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1092:
National Center for
Biotechnology Information, U.S. National Library of Medicine
421:
237:
134:
84:
1338:
1321:
1141:
1124:
1190:
669:
481:
359:
304:
291:
203:
190:
92:
1876:
1825:
1788:
1745:
1710:
1675:
1632:
1603:
1584:
1550:
1521:
1492:
1483:
1466:
1457:
1448:
1431:
1422:
1393:
1347:
1304:
1266:
1209:
1150:
979:
1736:
1719:
1384:
963:
814:
795:
1817:
1770:
974:
1858:
1296:
995:
781:
736:
947:
691:
1893:
17:
1624:
654:
650:
1901:
1123:
Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998).
1002:
72:
519:
1026:
List of conditions caused by problems with junctional proteins
1558:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
59:, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
328:
1913:
1465:
Jonca N, Guerrin M, Hadjiolova K, et al. (2002).
1841:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
493:
1683:
Caubet C, Jonca N, Brattsand M, et al. (2004).
1320:
Guerrin M, Simon M, Montézin M, et al. (1998).
1355:Jenisch S, Koch S, Henseler T, et al. (2000).
904:
883:
853:
832:
1066:
1064:
1062:
1045:
1043:
1041:
1430:Simon M, Jonca N, Guerrin M, et al. (2001).
275:
174:
1718:Capon F, Allen MH, Ameen M, et al. (2005).
1648:Caubet C, Jonca N, Lopez F, et al. (2004).
27:Protein-coding gene in the species Homo sapiens
1753:Yang T, Liang D, Koch PJ, et al. (2004).
1071:GRCm38: Ensembl release 89: ENSMUSG00000039518
1933:
8:
1050:GRCh38: Ensembl release 89: ENSG00000204539
1940:
1926:
665:
535:
316:
215:
112:
1866:
1778:
1735:
1700:
1665:
1593:
1583:
1482:
1447:
1383:
1337:
1199:
1189:
1140:
1221:
1219:
1037:
29:
280:
241:
236:
179:
138:
133:
7:
1890:
1888:
1415:10.1034/j.1399-0039.2001.057001032.x
635:negative regulation of cornification
1022:Hypertrichosis simplex of the scalp
1912:. You can help Knowledge (XXG) by
1259:10.1111/j.1365-2133.1974.tb12455.x
1227:"Entrez Gene: CDSN corneodesmosin"
901:
880:
850:
829:
805:
786:
760:
741:
715:
696:
498:
416:
354:
333:
25:
1543:10.1034/j.1399-0039.2002.600403.x
1514:10.1034/j.1399-0039.2002.600110.x
1376:10.1034/j.1399-0039.1999.540501.x
998:that in humans is encoded by the
553:protein homodimerization activity
1892:
1702:10.1111/j.0022-202X.2004.22512.x
1667:10.1111/j.0022-202X.2004.22331.x
509:
502:
264:
257:
251:
228:
163:
156:
150:
125:
1164:Zhou Y, Chaplin DD (Nov 1993).
520:More reference expression data
482:More reference expression data
1:
1964:Human chromosome 6 gene stubs
249:
148:
1564:Proc. Natl. Acad. Sci. U.S.A
615:keratinocyte differentiation
1959:Genes on human chromosome 6
456:subcutaneous adipose tissue
1985:
1887:
448:superior surface of tongue
1106:"Mouse PubMed Reference:"
1088:"Human PubMed Reference:"
978:
973:
969:
962:
946:
927:
908:
887:
876:
857:
836:
825:
812:
808:
793:
789:
780:
767:
763:
748:
744:
735:
722:
718:
703:
699:
690:
675:
668:
664:
648:
538:
534:
517:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
1339:10.1074/jbc.273.35.22640
1170:Proc Natl Acad Sci U S A
1142:10.1074/jbc.272.50.31770
940:Chr 17: 35.86 – 35.87 Mb
1191:10.1073/pnas.90.20.9470
933:Chr 6: 31.12 – 31.12 Mb
630:corneocyte desquamation
1585:10.1073/pnas.242603899
1484:10.1074/jbc.M108438200
1449:10.1074/jbc.M100201200
394:skeletal muscle tissue
620:epidermis development
243:Chromosome 17 (mouse)
569:extracellular region
460:white adipose tissue
436:skin of external ear
386:gastrocnemius muscle
141:Chromosome 6 (human)
1818:10.1038/nature04209
1810:2005Natur.437.1173R
1771:10.1101/gad.1232104
1689:J. Invest. Dermatol
1654:J. Invest. Dermatol
1576:2002PNAS...9916899M
1285:Arch. Dermatol. Res
1182:1993PNAS...90.9470Z
1900:This article on a
1859:10.1101/gr.4039406
1737:10.1093/hmg/ddh273
1297:10.1007/BF00371795
770:ENSMUSG00000039518
640:cell-cell adhesion
610:skin morphogenesis
598:Biological process
584:cornified envelope
579:cell-cell junction
562:Cellular component
546:Molecular function
1921:
1920:
1570:(26): 16899–903.
989:
988:
985:
984:
958:
957:
923:
922:
898:
897:
872:
871:
847:
846:
821:
820:
802:
801:
776:
775:
757:
756:
731:
730:
712:
711:
660:
659:
530:
529:
526:
525:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
1976:
1942:
1935:
1928:
1896:
1889:
1880:
1870:
1837:
1804:(7062): 1173–8.
1792:
1782:
1749:
1739:
1714:
1704:
1679:
1669:
1644:
1607:
1597:
1587:
1554:
1525:
1496:
1486:
1461:
1451:
1426:
1397:
1387:
1361:
1351:
1341:
1316:
1278:
1231:
1230:
1223:
1214:
1213:
1203:
1193:
1161:
1155:
1154:
1144:
1120:
1114:
1113:
1102:
1096:
1095:
1084:
1078:
1068:
1057:
1047:
971:
970:
942:
935:
918:
902:
893:
881:
877:RefSeq (protein)
867:
851:
842:
830:
806:
787:
761:
742:
716:
697:
666:
536:
522:
513:
506:
499:
484:
424:
422:Top expressed in
417:
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
105:CDSN - orthologs
58:
51:
30:
21:
1984:
1983:
1979:
1978:
1977:
1975:
1974:
1973:
1949:
1948:
1947:
1946:
1885:
1883:
1840:
1795:
1752:
1724:Hum. Mol. Genet
1717:
1682:
1647:
1610:
1557:
1531:Tissue Antigens
1528:
1502:Tissue Antigens
1499:
1464:
1442:(23): 20292–9.
1429:
1403:Tissue Antigens
1400:
1364:Tissue Antigens
1359:
1354:
1332:(35): 22640–7.
1319:
1281:
1247:Br. J. Dermatol
1244:
1240:
1238:Further reading
1235:
1234:
1225:
1224:
1217:
1163:
1162:
1158:
1135:(50): 31770–6.
1122:
1121:
1117:
1104:
1103:
1099:
1086:
1085:
1081:
1069:
1060:
1048:
1039:
1034:
1019:
980:View/Edit Mouse
975:View/Edit Human
938:
931:
928:Location (UCSC)
914:
910:
889:
863:
859:
838:
751:ENSG00000204539
644:
593:
589:plasma membrane
557:
518:
508:
507:
480:
471:
466:
462:
458:
454:
452:skin of abdomen
450:
446:
442:
438:
434:
420:
409:
404:
400:
396:
392:
388:
384:
380:
376:
372:
370:skin of abdomen
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
1982:
1980:
1972:
1971:
1966:
1961:
1951:
1950:
1945:
1944:
1937:
1930:
1922:
1919:
1918:
1897:
1882:
1881:
1838:
1793:
1765:(19): 2354–8.
1750:
1730:(20): 2361–8.
1715:
1695:(5): 1235–44.
1680:
1645:
1625:10.1038/ng1163
1608:
1555:
1526:
1497:
1462:
1427:
1398:
1352:
1317:
1279:
1241:
1239:
1236:
1233:
1232:
1215:
1176:(20): 9470–4.
1156:
1115:
1097:
1079:
1058:
1036:
1035:
1033:
1030:
1029:
1028:
1023:
1018:
1015:
992:Corneodesmosin
987:
986:
983:
982:
977:
967:
966:
960:
959:
956:
955:
953:
951:
944:
943:
936:
929:
925:
924:
921:
920:
906:
905:
899:
896:
895:
885:
884:
878:
874:
873:
870:
869:
855:
854:
848:
845:
844:
834:
833:
827:
823:
822:
819:
818:
810:
809:
803:
800:
799:
791:
790:
784:
778:
777:
774:
773:
765:
764:
758:
755:
754:
746:
745:
739:
733:
732:
729:
728:
720:
719:
713:
710:
709:
701:
700:
694:
688:
687:
682:
677:
673:
672:
662:
661:
658:
657:
646:
645:
643:
642:
637:
632:
627:
622:
617:
612:
607:
601:
599:
595:
594:
592:
591:
586:
581:
576:
571:
565:
563:
559:
558:
556:
555:
549:
547:
543:
542:
532:
531:
528:
527:
524:
523:
515:
514:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1981:
1970:
1967:
1965:
1962:
1960:
1957:
1956:
1954:
1943:
1938:
1936:
1931:
1929:
1924:
1923:
1917:
1915:
1911:
1907:
1903:
1898:
1895:
1891:
1886:
1878:
1874:
1869:
1864:
1860:
1856:
1852:
1848:
1844:
1839:
1835:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1794:
1790:
1786:
1781:
1776:
1772:
1768:
1764:
1760:
1756:
1751:
1747:
1743:
1738:
1733:
1729:
1725:
1721:
1716:
1712:
1708:
1703:
1698:
1694:
1690:
1686:
1681:
1677:
1673:
1668:
1663:
1660:(3): 747–54.
1659:
1655:
1651:
1646:
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1614:
1609:
1605:
1601:
1596:
1591:
1586:
1581:
1577:
1573:
1569:
1565:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1498:
1494:
1490:
1485:
1480:
1477:(7): 5024–9.
1476:
1472:
1471:J. Biol. Chem
1468:
1463:
1459:
1455:
1450:
1445:
1441:
1437:
1436:J. Biol. Chem
1433:
1428:
1424:
1420:
1416:
1412:
1408:
1404:
1399:
1395:
1391:
1386:
1385:2027.42/66173
1381:
1377:
1373:
1370:(5): 439–49.
1369:
1365:
1358:
1353:
1349:
1345:
1340:
1335:
1331:
1327:
1326:J. Biol. Chem
1323:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1291:(7): 369–75.
1290:
1286:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1253:(6): 687–96.
1252:
1248:
1243:
1242:
1237:
1228:
1222:
1220:
1216:
1211:
1207:
1202:
1197:
1192:
1187:
1183:
1179:
1175:
1171:
1167:
1160:
1157:
1152:
1148:
1143:
1138:
1134:
1130:
1126:
1119:
1116:
1111:
1107:
1101:
1098:
1093:
1089:
1083:
1080:
1076:
1072:
1067:
1065:
1063:
1059:
1055:
1051:
1046:
1044:
1042:
1038:
1031:
1027:
1024:
1021:
1020:
1016:
1014:
1012:
1006:
1004:
1001:
997:
993:
981:
976:
972:
968:
965:
961:
954:
952:
949:
945:
941:
937:
934:
930:
926:
919:
917:
913:
907:
903:
900:
894:
892:
886:
882:
879:
875:
868:
866:
862:
856:
852:
849:
843:
841:
835:
831:
828:
826:RefSeq (mRNA)
824:
817:
816:
811:
807:
804:
798:
797:
792:
788:
785:
783:
779:
772:
771:
766:
762:
759:
753:
752:
747:
743:
740:
738:
734:
727:
726:
721:
717:
714:
708:
707:
702:
698:
695:
693:
689:
686:
683:
681:
678:
674:
671:
667:
663:
656:
652:
647:
641:
638:
636:
633:
631:
628:
626:
625:cornification
623:
621:
618:
616:
613:
611:
608:
606:
605:cell adhesion
603:
602:
600:
597:
596:
590:
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572:
570:
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566:
564:
561:
560:
554:
551:
550:
548:
545:
544:
541:
540:Gene ontology
537:
533:
521:
516:
512:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
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405:
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397:
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389:
385:
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377:
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353:
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306:
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282:17|17 B1
278:
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267:
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222:
217:
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205:
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136:
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78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1914:expanding it
1906:chromosome 6
1899:
1884:
1853:(1): 55–65.
1850:
1846:
1801:
1797:
1762:
1758:
1727:
1723:
1692:
1688:
1657:
1653:
1619:(2): 151–3.
1616:
1612:
1567:
1563:
1537:(4): 292–8.
1534:
1530:
1508:(1): 77–83.
1505:
1501:
1474:
1470:
1439:
1435:
1406:
1402:
1367:
1363:
1329:
1325:
1288:
1284:
1250:
1246:
1173:
1169:
1159:
1132:
1128:
1118:
1109:
1100:
1091:
1082:
1011:desquamation
1007:
999:
991:
990:
916:NP_001342204
912:NP_001008424
909:
888:
865:NM_001355275
861:NM_001008424
858:
837:
813:
794:
768:
749:
723:
704:
684:
679:
444:skin of back
344:
337:
64:External IDs
1409:(1): 32–8.
1129:J Biol Chem
402:gallbladder
374:skin of leg
303:35,868,077
290:35,863,025
202:31,120,446
189:31,115,087
42:Identifiers
1953:Categories
1847:Genome Res
1613:Nat. Genet
1077:, May 2017
1056:, May 2017
1032:References
348:(ortholog)
85:HomoloGene
1904:on human
1759:Genes Dev
891:NP_001255
840:NM_001264
670:Orthologs
574:desmosome
440:esophagus
93:GeneCards
1877:16344560
1826:16189514
1789:15466487
1746:15333584
1711:15140227
1676:15086562
1641:10116539
1633:12754508
1604:12477932
1551:12472658
1522:12366786
1493:11739386
1458:11279026
1423:11169256
1394:10599883
1275:28843515
1073:–
1052:–
1017:See also
964:Wikidata
649:Sources:
468:gastrula
406:duodenum
382:placenta
378:testicle
1969:Plakins
1868:1356129
1834:4427026
1806:Bibcode
1572:Bibcode
1348:9712893
1305:7818278
1267:4141628
1210:8415725
1178:Bibcode
1151:9395522
1075:Ensembl
1054:Ensembl
996:protein
782:UniProt
737:Ensembl
676:Species
655:QuickGO
323:pattern
181:6p21.33
81:3505689
49:Aliases
1875:
1865:
1832:
1824:
1798:Nature
1787:
1780:522985
1777:
1744:
1709:
1674:
1639:
1631:
1602:
1595:139241
1592:
1549:
1520:
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1392:
1346:
1313:614870
1311:
1303:
1273:
1265:
1208:
1198:
1149:
950:search
948:PubMed
815:Q7TPC1
796:Q15517
725:386463
692:Entrez
494:BioGPS
464:cervix
398:tonsil
390:vagina
73:602593
1908:is a
1830:S2CID
1637:S2CID
1360:(PDF)
1309:S2CID
1271:S2CID
1201:47590
994:is a
685:Mouse
680:Human
651:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:48005
1910:stub
1902:gene
1873:PMID
1822:PMID
1785:PMID
1742:PMID
1707:PMID
1672:PMID
1629:PMID
1600:PMID
1547:PMID
1518:PMID
1489:PMID
1454:PMID
1419:PMID
1390:PMID
1344:PMID
1301:PMID
1263:PMID
1206:PMID
1147:PMID
1003:gene
1000:CDSN
706:1041
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
97:CDSN
69:OMIM
56:CDSN
33:CDSN
18:CDSN
1863:PMC
1855:doi
1814:doi
1802:437
1775:PMC
1767:doi
1732:doi
1697:doi
1693:122
1662:doi
1658:122
1621:doi
1590:PMC
1580:doi
1539:doi
1510:doi
1479:doi
1475:277
1444:doi
1440:276
1411:doi
1380:hdl
1372:doi
1334:doi
1330:273
1293:doi
1289:286
1255:doi
1196:PMC
1186:doi
1137:doi
1133:272
432:lip
299:End
198:End
101:OMA
77:MGI
1955::
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1249:.
1218:^
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1168:.
1145:.
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1127:.
1108:.
1090:.
1061:^
1040:^
1005:.
653:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
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87::
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71::
1941:e
1934:t
1927:v
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