324:
301:
198:
223:
330:
229:
31:
57:
2781:"Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase"
1183:. This proteins is frequently accompanied by "centrochromatin"-associated changes to canonical histones and is constitutively present in centromeres. The CENPA protein is a histone H3 variant which replaces one or both
2723:
Tomonaga T, Matsushita K, Yamaguchi S, Oohashi T, Shimada H, Ochiai T, et al. (July 2003). "Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer".
3527:
337:
236:
2822:
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, et al. (April 2004). "Cdc42 and mDia3 regulate microtubule attachment to kinetochores".
3028:
824:
805:
159:
1745:
Schuh M, Lehner CF, Heidmann S (February 2007). "Incorporation of
Drosophila CID/CENP-A and CENP-C into centromeres during early embryonic anaphase".
1195:. CENPA has the greatest sequence divergence of the histone H3 variants, with just 48% similarity to canonical histone H3, and has a highly diverged
2867:
Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL, Cleveland DW (July 2004). "Structural determinants for generating centromeric chromatin".
1254:
at the protein level through a purely epigenetic mechanism. This means that the position of CENPA protein binding to the genome is copied upon
1390:
3517:
3158:
1370:
1352:
3548:
3522:
2395:"Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3"
2746:"CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function"
2690:"Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc"
323:
2364:
Fowler KJ, Newson AJ, MacDonald AC, Kalitsis P, Lyu MS, Kozak CA, et al. (1998). "Chromosomal localization of mouse Cenpa gene".
2155:
2438:"Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0"
1258:
to the two daughter cells independent of the underlying DNA sequence. Under circumstances in which CENPA is lost from a chromosome a
1064:
3021:
1071:
300:
2567:"CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells"
1175:
defines the position of the centromere on each chromosome, determining the position of kinetochore assembly and the final site of
1339:
1318:
2610:"Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated"
1949:"Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles"
1335:
2161:
222:
197:
54:
3143:
2914:"Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin"
1314:
3014:
139:
1863:
Gurard-Levin ZA, Quivy JP, Almouzni G (2014). "Histone chaperones: assisting histone traffic and nucleosome dynamics".
336:
235:
2473:"Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype"
329:
228:
3290:
2237:"Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere"
1243:
3344:
3128:
869:
147:
2280:"Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites"
1239:
850:
2184:"Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone"
3297:
3280:
3250:
3223:
1290:
3285:
3183:
1451:
Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente LP, Nguyen K, Wong AJ, et al. (September 2013).
2524:"CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis"
2047:"The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle"
3505:
3430:
3415:
3245:
3193:
3168:
3108:
2968:
2876:
2831:
2484:
2195:
2107:
1819:
1754:
1263:
1200:
211:
2323:"A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A"
126:
3173:
2167:
1231:
1043:
1039:
1035:
1031:
1006:
980:
976:
972:
968:
943:
1600:"Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points"
1500:
Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, et al. (April 2022).
2900:
2855:
2810:
2510:
2352:
1788:
1267:
171:
2744:
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, et al. (December 2003).
1598:
Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, et al. (March 2017).
1047:
1010:
964:
939:
1808:"Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle"
3235:
3147:
2994:
2943:
2892:
2847:
2802:
2767:
2732:
2711:
2676:
2631:
2596:
2553:
2502:
2459:
2424:
2381:
2344:
2309:
2266:
2223:
2133:
2076:
2027:
1978:
1929:
1880:
1845:
1780:
1727:
1678:
1629:
1580:
1531:
1482:
1433:
1176:
119:
47:
3425:
3324:
2984:
2976:
2933:
2925:
2884:
2839:
2792:
2757:
2701:
2666:
2656:
2621:
2586:
2578:
2543:
2535:
2492:
2449:
2414:
2406:
2373:
2334:
2299:
2291:
2256:
2248:
2213:
2203:
2123:
2115:
2066:
2058:
2017:
2009:
1968:
1960:
1919:
1911:
1872:
1835:
1827:
1770:
1762:
1717:
1709:
1668:
1660:
1619:
1611:
1570:
1562:
1521:
1513:
1472:
1464:
1423:
1415:
1145:
416:
347:
291:
246:
3480:
3475:
167:
3317:
3138:
3086:
1876:
1775:
1211:
391:
2471:
Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, et al. (November 2000).
2096:"Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome"
2972:
2880:
2835:
2488:
2199:
2111:
1823:
1758:
3208:
3132:
2989:
2956:
2938:
2913:
2548:
2523:
2419:
2394:
2393:
Muro Y, Azuma N, Onouchi H, Kunimatsu M, Tomita Y, Sasaki M, et al. (April 2000).
2304:
2279:
2261:
2236:
2128:
2095:
2071:
2046:
2022:
1997:
1973:
1948:
1924:
1899:
1840:
1807:
1806:
Shukla M, Tong P, White SA, Singh PP, Reid AM, Catania S, et al. (December 2018).
1722:
1697:
1673:
1648:
1624:
1599:
1575:
1550:
1526:
1501:
1477:
1453:"A two-step mechanism for epigenetic specification of centromere identity and function"
1452:
1428:
1403:
1247:
1230:
in S. pombe. To orchestrate this specialised loading there are CENPA-specific histone
30:
2762:
2745:
2671:
2644:
2591:
2566:
2497:
2472:
2339:
2322:
1566:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
678:
673:
668:
663:
658:
653:
648:
643:
627:
622:
617:
612:
607:
3542:
3188:
2797:
2780:
2410:
2218:
2183:
2094:
Yan K, Yang J, Zhang Z, McLaughlin SH, Chang L, Fasci D, et al. (October 2019).
1255:
594:
2814:
2582:
2514:
2356:
1792:
3163:
3037:
2904:
2859:
409:
188:
151:
2957:"The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres"
175:
3382:
3377:
3240:
3218:
3213:
3081:
1375:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1357:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1286:
1274:
1172:
1149:
2188:
Proceedings of the
National Academy of Sciences of the United States of America
492:
3402:
3392:
3387:
3372:
3312:
3302:
3203:
3178:
3152:
3103:
3093:
3041:
2688:
Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH (September 2002).
2119:
1947:
Aldrup-MacDonald ME, Kuo ME, Sullivan LL, Chew K, Sullivan BA (October 2016).
1915:
1831:
1766:
1664:
1215:
1207:
1196:
1188:
1184:
1156:
1152:
1142:
308:
205:
155:
2706:
2689:
2013:
3354:
3098:
3076:
3057:
3006:
1517:
1259:
1192:
1160:
769:
552:
430:
375:
362:
274:
261:
163:
2998:
2947:
2896:
2851:
2806:
2771:
2736:
2715:
2680:
2661:
2635:
2626:
2609:
2600:
2557:
2506:
2463:
2454:
2437:
2428:
2208:
2137:
2080:
2031:
1982:
1933:
1884:
1849:
1784:
1731:
1682:
1633:
1584:
1535:
1486:
1437:
2539:
2385:
2348:
2313:
2295:
2270:
2252:
2227:
1964:
1713:
1615:
1111:
1106:
3340:
3124:
1251:
1227:
1219:
1095:
914:
895:
2980:
2888:
2843:
2062:
3510:
3364:
3275:
3270:
1404:"Epigenetic regulation of centromeric chromatin: old dogs, new tricks?"
1223:
1180:
1131:
881:
836:
2779:
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004).
2377:
96:
92:
88:
84:
80:
76:
3420:
3307:
3071:
3067:
3062:
2182:
Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL (May 1991).
1998:"Centromeres: genetic input to calibrate an epigenetic feedback loop"
1551:"Conserved organization of centromeric chromatin in flies and humans"
1387:
1278:
1079:
791:
2929:
1468:
1419:
1246:. In most eukaryotes CENPA is loaded into large domains of highly
3485:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3348:
1282:
1235:
1698:"Propagation of centromeric chromatin requires exit from mitosis"
1649:"Posttranslational modifications of CENP-A: marks of distinction"
754:
750:
2645:"Molecular cloning and sequence analysis of hamster CENP-A cDNA"
1138:
143:
3010:
2608:
Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH (July 2002).
2955:
Sekulic N, Bassett EA, Rogers DJ, Black BE (September 2010).
2321:
Valdivia MM, Figueroa J, Iglesias C, OrtΓz M (January 1998).
1502:"Complete genomic and epigenetic maps of human centromeres"
2565:
Ando S, Yang H, Nozaki N, Okazaki T, Yoda K (April 2002).
1696:
Jansen LE, Black BE, Foltz DR, Cleveland DW (March 2007).
399:
3528:
International System for Human
Cytogenetic Nomenclature
2235:
Sullivan KF, Hechenberger M, Masri K (November 1994).
705:
protein localization to chromosome, centromeric region
1270:
to repopulate the centromere with CENPA nucleosomes.
1262:
mechanism has been described in human cells in which
564:
2522:
Zeitlin SG, Shelby RD, Sullivan KF (December 2001).
2436:
Lomonte P, Sullivan KF, Everett RD (February 2001).
3498:
3401:
3363:
3333:
3261:
3117:
3048:
1206:Unusually for a histone, CENPA nucleosomes are not
1024:
999:
957:
932:
1331:
1329:
1327:
1310:
1308:
1306:
1250:. The position of CENPA within satellite DNA are
346:
245:
2278:Shelby RD, Vafa O, Sullivan KF (February 1997).
1900:"Centromere identity from the DNA point of view"
1898:Plohl M, MeΕ‘troviΔ N, Mravinac B (August 2014).
1549:Blower MD, Sullivan BA, Karpen GH (March 2002).
16:Protein-coding gene in the species Homo sapiens
2643:Figueroa J, PendΓ³n C, Valdivia MM (May 2002).
1336:GRCm38: Ensembl release 89: ENSMUSG00000029177
3022:
2045:Kixmoeller K, Allu PK, Black BE (June 2020).
1148:which is the critical factor determining the
8:
700:establishment of mitotic spindle orientation
1996:van den Berg SJ, Jansen LE (October 2020).
1315:GRCh38: Ensembl release 89: ENSG00000115163
3360:
3029:
3015:
3007:
765:
590:
387:
286:
183:
65:
2988:
2937:
2918:Nature Structural & Molecular Biology
2796:
2761:
2705:
2670:
2660:
2625:
2590:
2547:
2496:
2453:
2418:
2338:
2303:
2260:
2217:
2207:
2127:
2070:
2021:
1972:
1923:
1839:
1774:
1721:
1672:
1647:Srivastava S, Foltz DR (September 2018).
1623:
1574:
1525:
1476:
1427:
2912:Sullivan BA, Karpen GH (November 2004).
1402:Allshire RC, Karpen GH (December 2008).
1302:
1203:sites including H3K4, H3K9 and H3K27.
20:
3518:List of organisms by chromosome count
1877:10.1146/annurev-biochem-060713-035536
351:
312:
307:
250:
209:
204:
130:, CENP-A, CenH3, centromere protein A
7:
2399:Clinical and Experimental Immunology
695:CENP-A containing chromatin assembly
2614:The Journal of Biological Chemistry
2442:The Journal of Biological Chemistry
1199:that lacks many well characterised
623:protein heterodimerization activity
1273:CENPA interacts directly with the
1134:which in humans is encoded by the
1021:
996:
954:
929:
905:
886:
860:
841:
815:
796:
569:
487:
425:
404:
14:
2798:10.1111/j.1365-2443.2004.00705.x
2411:10.1046/j.1365-2249.2000.01189.x
1285:. Through this interaction the
335:
328:
322:
299:
234:
227:
221:
196:
29:
3139:Macrochromosome/Microchromosome
2583:10.1128/MCB.22.7.2229-2241.2002
1266:recruits CENPA via a satellite
1218:stages in different organisms:
2571:Molecular and Cellular Biology
2366:Cytogenetics and Cell Genetics
1776:11858/00-001M-0000-002A-23E4-7
664:chromosome, centromeric region
553:More reference expression data
1:
2763:10.1016/S1534-5807(03)00364-2
2498:10.1016/S0960-9822(00)00769-7
2340:10.1016/S0014-5793(97)01583-4
1865:Annual Review of Biochemistry
1567:10.1016/s1534-5807(02)00135-1
320:
219:
1214:and are loaded at different
3549:Genes on human chromosome 2
2528:The Journal of Cell Biology
2284:The Journal of Cell Biology
2241:The Journal of Cell Biology
1702:The Journal of Cell Biology
1604:The Journal of Cell Biology
1277:through proteins including
3565:
3179:Dinoflagellate chromosomes
2166:gene details page in the
515:medial ganglionic eminence
3523:List of sequenced genomes
3291:Chromosomal translocation
3164:A chromosome/B chromosome
3155:(or accessory chromosome)
2120:10.1038/s41586-019-1609-1
1916:10.1007/s00412-014-0462-0
1832:10.1016/j.cub.2018.10.049
1767:10.1016/j.cub.2006.11.051
1665:10.1007/s00412-018-0665-x
1371:"Mouse PubMed Reference:"
1353:"Human PubMed Reference:"
1171:CENPA is a protein which
1110:
1105:
1101:
1094:
1078:
1059:
1028:
1003:
992:
961:
936:
925:
912:
908:
893:
889:
880:
867:
863:
848:
844:
835:
822:
818:
803:
799:
790:
775:
768:
764:
748:
720:sister chromatid cohesion
593:
589:
577:
572:
563:
550:
499:
490:
437:
428:
398:
390:
386:
369:
356:
319:
298:
289:
285:
268:
255:
218:
195:
186:
182:
137:
134:
124:
117:
112:
73:
68:
51:
46:
41:
37:
28:
23:
3345:Telomere-binding protein
3159:Supernumerary chromosome
2694:Human Molecular Genetics
2014:10.15252/embj.2020106638
1408:Nature Reviews. Genetics
1248:repetitive satellite DNA
1518:10.1126/science.abl4178
1289:are able to accurately
1072:Chr 5: 30.82 β 30.83 Mb
628:nucleosomal DNA binding
3281:Structural alterations
2707:10.1093/hmg/11.19.2319
2662:10.1186/1471-2164-3-11
2627:10.1074/jbc.M200620200
2455:10.1074/jbc.M008547200
2209:10.1073/pnas.88.9.3734
1065:Chr 2: 26.76 β 26.8 Mb
3298:Numerical alterations
3286:Chromosomal inversion
3184:Homologous chromosome
2540:10.1083/jcb.200108125
2296:10.1083/jcb.136.3.501
2253:10.1083/jcb.127.3.581
1965:10.1101/gr.206706.116
1714:10.1083/jcb.200701066
1616:10.1083/jcb.201608083
1291:segregate chromosomes
1226:phase in drosophila,
1185:canonical H3 histones
523:mandibular prominence
3506:Extrachromosomal DNA
3194:Satellite chromosome
3169:Lampbrush chromosome
3109:Nuclear organization
2160:genome location and
1818:(24): 3924β3936.e4.
1201:histone modification
1124:Centromere protein A
715:kinetochore assembly
519:maxillary prominence
353:5 B1|5 16.76 cM
314:Chromosome 5 (mouse)
212:Chromosome 2 (human)
69:List of PDB id codes
42:Available structures
3199:Centromere position
3174:Polytene chromosome
3144:Circular chromosome
2981:10.1038/nature09323
2973:2010Natur.467..347S
2889:10.1038/nature02766
2881:2004Natur.430..578B
2844:10.1038/nature02452
2836:2004Natur.428..767Y
2620:(30): 26921β26926.
2489:2000CBio...10.1319U
2200:1991PNAS...88.3734P
2168:UCSC Genome Browser
2112:2019Natur.574..278Y
2063:10.1098/rsob.200051
1824:2018CBio...28E3924S
1759:2007CBio...17..237S
1457:Nature Cell Biology
1191:within centromeric
740:nucleosome assembly
725:mitotic cytokinesis
503:endocardial cushion
461:ganglionic eminence
2750:Developmental Cell
1555:Developmental Cell
1512:(6588): eabl4178.
1268:DNA binding domain
1238:in human, CAL1 in
1163:including humans.
870:ENSMUSG00000029177
688:Biological process
637:Cellular component
601:Molecular function
457:buccal mucosa cell
3536:
3535:
3494:
3493:
3231:Centromere number
3148:Linear chromosome
2967:(7313): 347β351.
2924:(11): 1076β1083.
2875:(6999): 578β582.
2830:(6984): 767β771.
2731:(13): 3511β3516.
2700:(19): 2319β2329.
2483:(21): 1319β1328.
2378:10.1159/000134748
2106:(7777): 278β282.
1959:(10): 1301β1311.
1275:inner kinetochore
1121:
1120:
1117:
1116:
1090:
1089:
1055:
1054:
1018:
1017:
988:
987:
951:
950:
921:
920:
902:
901:
876:
875:
857:
856:
831:
830:
812:
811:
760:
759:
644:inner kinetochore
613:chromatin binding
585:
584:
581:
580:
559:
558:
546:
545:
484:
483:
382:
381:
281:
280:
176:CENPA - orthologs
108:
107:
104:
103:
52:Ortholog search:
3556:
3361:
3325:Polyploidization
3153:Extra chromosome
3068:Genetic material
3031:
3024:
3017:
3008:
3002:
2992:
2951:
2941:
2908:
2863:
2818:
2800:
2775:
2765:
2740:
2719:
2709:
2684:
2674:
2664:
2639:
2629:
2604:
2594:
2577:(7): 2229β2241.
2561:
2551:
2534:(7): 1147β1157.
2518:
2500:
2467:
2457:
2448:(8): 5829β5835.
2432:
2422:
2389:
2372:(3β4): 298β301.
2360:
2342:
2317:
2307:
2274:
2264:
2231:
2221:
2211:
2194:(9): 3734β3738.
2142:
2141:
2131:
2091:
2085:
2084:
2074:
2042:
2036:
2035:
2025:
2002:The EMBO Journal
1993:
1987:
1986:
1976:
1944:
1938:
1937:
1927:
1895:
1889:
1888:
1860:
1854:
1853:
1843:
1803:
1797:
1796:
1778:
1742:
1736:
1735:
1725:
1693:
1687:
1686:
1676:
1644:
1638:
1637:
1627:
1595:
1589:
1588:
1578:
1546:
1540:
1539:
1529:
1497:
1491:
1490:
1480:
1463:(9): 1056β1066.
1448:
1442:
1441:
1431:
1399:
1393:
1385:
1379:
1378:
1367:
1361:
1360:
1349:
1343:
1333:
1322:
1312:
1293:during mitosis.
1222:phase in human,
1179:cohesion during
1177:sister chromatid
1126:, also known as
1103:
1102:
1074:
1067:
1050:
1022:
1013:
997:
993:RefSeq (protein)
983:
955:
946:
930:
906:
887:
861:
842:
816:
797:
766:
591:
570:
555:
531:primitive streak
507:ventricular zone
495:
493:Top expressed in
488:
453:ventricular zone
445:secondary oocyte
433:
431:Top expressed in
426:
405:
388:
378:
365:
354:
339:
332:
326:
315:
303:
287:
277:
264:
253:
238:
231:
225:
214:
200:
184:
178:
129:
122:
99:
66:
60:
39:
38:
33:
21:
3564:
3563:
3559:
3558:
3557:
3555:
3554:
3553:
3539:
3538:
3537:
3532:
3490:
3397:
3359:
3329:
3318:Paleopolyploidy
3263:
3257:
3113:
3087:Heterochromatin
3050:
3044:
3035:
3005:
2954:
2930:10.1038/nsmb845
2911:
2866:
2821:
2778:
2743:
2725:Cancer Research
2722:
2687:
2642:
2607:
2564:
2521:
2477:Current Biology
2470:
2435:
2392:
2363:
2320:
2277:
2234:
2181:
2177:
2175:Further reading
2151:
2146:
2145:
2093:
2092:
2088:
2044:
2043:
2039:
2008:(20): e106638.
1995:
1994:
1990:
1953:Genome Research
1946:
1945:
1941:
1897:
1896:
1892:
1862:
1861:
1857:
1812:Current Biology
1805:
1804:
1800:
1747:Current Biology
1744:
1743:
1739:
1695:
1694:
1690:
1646:
1645:
1641:
1597:
1596:
1592:
1548:
1547:
1543:
1499:
1498:
1494:
1469:10.1038/ncb2805
1450:
1449:
1445:
1420:10.1038/nrg2466
1414:(12): 923β937.
1401:
1400:
1396:
1386:
1382:
1369:
1368:
1364:
1351:
1350:
1346:
1334:
1325:
1313:
1304:
1299:
1212:DNA replication
1197:N-terminal tail
1187:in a subset of
1169:
1112:View/Edit Mouse
1107:View/Edit Human
1070:
1063:
1060:Location (UCSC)
1046:
1042:
1038:
1034:
1030:
1009:
1005:
979:
975:
971:
967:
963:
942:
938:
851:ENSG00000115163
744:
683:
632:
618:protein binding
551:
542:
537:
533:
529:
525:
521:
517:
513:
511:renal corpuscle
509:
505:
491:
480:
475:
473:trabecular bone
471:
467:
463:
459:
455:
451:
447:
443:
429:
373:
360:
352:
342:
341:
340:
333:
313:
290:Gene location (
272:
259:
251:
241:
240:
239:
232:
210:
187:Gene location (
138:
125:
118:
75:
53:
17:
12:
11:
5:
3562:
3560:
3552:
3551:
3541:
3540:
3534:
3533:
3531:
3530:
3525:
3520:
3515:
3514:
3513:
3502:
3500:
3496:
3495:
3492:
3491:
3489:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3448:
3443:
3438:
3433:
3428:
3423:
3418:
3413:
3407:
3405:
3399:
3398:
3396:
3395:
3390:
3385:
3380:
3375:
3369:
3367:
3358:
3357:
3352:
3337:
3335:
3331:
3330:
3328:
3327:
3322:
3321:
3320:
3315:
3310:
3305:
3295:
3294:
3293:
3288:
3278:
3273:
3267:
3265:
3259:
3258:
3256:
3255:
3254:
3253:
3248:
3243:
3238:
3228:
3227:
3226:
3221:
3216:
3211:
3209:Submetacentric
3206:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3150:
3141:
3136:
3135:or heterosome)
3129:Sex chromosome
3121:
3119:
3115:
3114:
3112:
3111:
3106:
3101:
3096:
3091:
3090:
3089:
3084:
3074:
3065:
3060:
3054:
3052:
3046:
3045:
3036:
3034:
3033:
3026:
3019:
3011:
3004:
3003:
2952:
2909:
2864:
2819:
2791:(2): 105β120.
2785:Genes to Cells
2776:
2756:(6): 853β864.
2741:
2720:
2685:
2640:
2605:
2562:
2519:
2468:
2433:
2405:(1): 218β223.
2390:
2361:
2318:
2290:(3): 501β513.
2275:
2247:(3): 581β592.
2232:
2178:
2176:
2173:
2172:
2171:
2150:
2149:External links
2147:
2144:
2143:
2086:
2037:
1988:
1939:
1910:(4): 313β325.
1890:
1855:
1798:
1753:(3): 237β243.
1737:
1708:(6): 795β805.
1688:
1659:(3): 279β290.
1639:
1610:(3): 607β621.
1590:
1561:(3): 319β330.
1541:
1492:
1443:
1394:
1380:
1362:
1344:
1323:
1301:
1300:
1298:
1295:
1210:together with
1173:epigenetically
1168:
1165:
1119:
1118:
1115:
1114:
1109:
1099:
1098:
1092:
1091:
1088:
1087:
1085:
1083:
1076:
1075:
1068:
1061:
1057:
1056:
1053:
1052:
1026:
1025:
1019:
1016:
1015:
1001:
1000:
994:
990:
989:
986:
985:
959:
958:
952:
949:
948:
934:
933:
927:
923:
922:
919:
918:
910:
909:
903:
900:
899:
891:
890:
884:
878:
877:
874:
873:
865:
864:
858:
855:
854:
846:
845:
839:
833:
832:
829:
828:
820:
819:
813:
810:
809:
801:
800:
794:
788:
787:
782:
777:
773:
772:
762:
761:
758:
757:
746:
745:
743:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
691:
689:
685:
684:
682:
681:
676:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
631:
630:
625:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
575:
574:
567:
561:
560:
557:
556:
548:
547:
544:
543:
541:
540:
539:tail of embryo
536:
532:
528:
527:abdominal wall
524:
520:
516:
512:
508:
504:
500:
497:
496:
485:
482:
481:
479:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
435:
434:
422:
421:
413:
402:
396:
395:
392:RNA expression
384:
383:
380:
379:
371:
367:
366:
358:
355:
350:
344:
343:
334:
327:
321:
317:
316:
311:
305:
304:
296:
295:
283:
282:
279:
278:
270:
266:
265:
257:
254:
249:
243:
242:
233:
226:
220:
216:
215:
208:
202:
201:
193:
192:
180:
179:
136:
132:
131:
123:
115:
114:
110:
109:
106:
105:
102:
101:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3561:
3550:
3547:
3546:
3544:
3529:
3526:
3524:
3521:
3519:
3516:
3512:
3509:
3508:
3507:
3504:
3503:
3501:
3497:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3414:
3412:
3409:
3408:
3406:
3404:
3400:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3370:
3368:
3366:
3362:
3356:
3353:
3350:
3346:
3342:
3339:
3338:
3336:
3332:
3326:
3323:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3300:
3299:
3296:
3292:
3289:
3287:
3284:
3283:
3282:
3279:
3277:
3274:
3272:
3269:
3268:
3266:
3264:and evolution
3260:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3233:
3232:
3229:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3201:
3200:
3197:
3195:
3192:
3190:
3189:Isochromosome
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3154:
3151:
3149:
3145:
3142:
3140:
3137:
3134:
3130:
3126:
3123:
3122:
3120:
3116:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3088:
3085:
3083:
3080:
3079:
3078:
3075:
3073:
3069:
3066:
3064:
3061:
3059:
3056:
3055:
3053:
3047:
3043:
3039:
3032:
3027:
3025:
3020:
3018:
3013:
3012:
3009:
3000:
2996:
2991:
2986:
2982:
2978:
2974:
2970:
2966:
2962:
2958:
2953:
2949:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2910:
2906:
2902:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2865:
2861:
2857:
2853:
2849:
2845:
2841:
2837:
2833:
2829:
2825:
2820:
2816:
2812:
2808:
2804:
2799:
2794:
2790:
2786:
2782:
2777:
2773:
2769:
2764:
2759:
2755:
2751:
2747:
2742:
2738:
2734:
2730:
2726:
2721:
2717:
2713:
2708:
2703:
2699:
2695:
2691:
2686:
2682:
2678:
2673:
2668:
2663:
2658:
2654:
2650:
2646:
2641:
2637:
2633:
2628:
2623:
2619:
2615:
2611:
2606:
2602:
2598:
2593:
2588:
2584:
2580:
2576:
2572:
2568:
2563:
2559:
2555:
2550:
2545:
2541:
2537:
2533:
2529:
2525:
2520:
2516:
2512:
2508:
2504:
2499:
2494:
2490:
2486:
2482:
2478:
2474:
2469:
2465:
2461:
2456:
2451:
2447:
2443:
2439:
2434:
2430:
2426:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2391:
2387:
2383:
2379:
2375:
2371:
2367:
2362:
2358:
2354:
2350:
2346:
2341:
2336:
2332:
2328:
2324:
2319:
2315:
2311:
2306:
2301:
2297:
2293:
2289:
2285:
2281:
2276:
2272:
2268:
2263:
2258:
2254:
2250:
2246:
2242:
2238:
2233:
2229:
2225:
2220:
2215:
2210:
2205:
2201:
2197:
2193:
2189:
2185:
2180:
2179:
2174:
2169:
2165:
2164:
2159:
2158:
2153:
2152:
2148:
2139:
2135:
2130:
2125:
2121:
2117:
2113:
2109:
2105:
2101:
2097:
2090:
2087:
2082:
2078:
2073:
2068:
2064:
2060:
2057:(6): 200051.
2056:
2052:
2048:
2041:
2038:
2033:
2029:
2024:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1989:
1984:
1980:
1975:
1970:
1966:
1962:
1958:
1954:
1950:
1943:
1940:
1935:
1931:
1926:
1921:
1917:
1913:
1909:
1905:
1901:
1894:
1891:
1886:
1882:
1878:
1874:
1870:
1866:
1859:
1856:
1851:
1847:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1813:
1809:
1802:
1799:
1794:
1790:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1741:
1738:
1733:
1729:
1724:
1719:
1715:
1711:
1707:
1703:
1699:
1692:
1689:
1684:
1680:
1675:
1670:
1666:
1662:
1658:
1654:
1650:
1643:
1640:
1635:
1631:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1594:
1591:
1586:
1582:
1577:
1572:
1568:
1564:
1560:
1556:
1552:
1545:
1542:
1537:
1533:
1528:
1523:
1519:
1515:
1511:
1507:
1503:
1496:
1493:
1488:
1484:
1479:
1474:
1470:
1466:
1462:
1458:
1454:
1447:
1444:
1439:
1435:
1430:
1425:
1421:
1417:
1413:
1409:
1405:
1398:
1395:
1392:
1389:
1384:
1381:
1376:
1372:
1366:
1363:
1358:
1354:
1348:
1345:
1341:
1337:
1332:
1330:
1328:
1324:
1320:
1316:
1311:
1309:
1307:
1303:
1296:
1294:
1292:
1288:
1284:
1280:
1276:
1271:
1269:
1265:
1261:
1257:
1256:cell division
1253:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
1204:
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1166:
1164:
1162:
1158:
1154:
1151:
1147:
1144:
1141:. CENPA is a
1140:
1137:
1133:
1129:
1125:
1113:
1108:
1104:
1100:
1097:
1093:
1086:
1084:
1081:
1077:
1073:
1069:
1066:
1062:
1058:
1051:
1049:
1045:
1041:
1037:
1033:
1027:
1023:
1020:
1014:
1012:
1008:
1002:
998:
995:
991:
984:
982:
978:
974:
970:
966:
960:
956:
953:
947:
945:
941:
935:
931:
928:
926:RefSeq (mRNA)
924:
917:
916:
911:
907:
904:
898:
897:
892:
888:
885:
883:
879:
872:
871:
866:
862:
859:
853:
852:
847:
843:
840:
838:
834:
827:
826:
821:
817:
814:
808:
807:
802:
798:
795:
793:
789:
786:
783:
781:
778:
774:
771:
767:
763:
756:
752:
747:
741:
738:
736:
735:cell division
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
710:viral process
708:
706:
703:
701:
698:
696:
693:
692:
690:
687:
686:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
568:
566:
562:
554:
549:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
501:
498:
494:
489:
486:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
439:
436:
432:
427:
424:
423:
420:
418:
414:
412:
411:
407:
406:
403:
401:
397:
393:
389:
385:
377:
372:
368:
364:
359:
349:
345:
338:
331:
325:
318:
310:
306:
302:
297:
293:
288:
284:
276:
271:
267:
263:
258:
248:
244:
237:
230:
224:
217:
213:
207:
203:
199:
194:
190:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
133:
128:
121:
116:
111:
100:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3410:
3230:
3198:
3038:Cytogenetics
2964:
2960:
2921:
2917:
2872:
2868:
2827:
2823:
2788:
2784:
2753:
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2649:BMC Genomics
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2054:
2051:Open Biology
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2005:
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1347:
1287:microtubules
1272:
1242:and Scm3 in
1205:
1170:
1135:
1127:
1123:
1122:
1044:NP_001289061
1040:NP_001289060
1036:NP_001289059
1032:NP_001289058
1029:
1007:NP_001035891
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981:NM_001302132
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973:NM_001302130
969:NM_001302129
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944:NM_001042426
937:
913:
894:
868:
849:
823:
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535:otic placode
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135:External IDs
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3241:Monocentric
3224:Holocentric
3219:Acrocentric
3214:Telocentric
3204:Metacentric
3082:Euchromatin
3042:chromosomes
1871:: 487β517.
1189:nucleosomes
1153:position(s)
1150:kinetochore
674:kinetochore
654:nucleoplasm
608:DNA binding
477:bone marrow
374:30,832,174
361:30,824,121
273:26,801,067
260:26,764,289
113:Identifiers
3403:Centromere
3334:Structures
3313:Polyploidy
3303:Aneuploidy
3104:Nucleosome
3094:Chromosome
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1904:Chromosoma
1653:Chromosoma
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1342:, May 2017
1321:, May 2017
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1161:eukaryotes
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