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1246:
protein that starts to appear at DNA damage in less than a second, with half maximum accumulation within 1.6 seconds after the damage occurs. Next the chromatin remodeler CHD1L (ALC1) quickly attaches to the product of PARP1, and completes arrival at the DNA damage within 10 seconds of the damage.
1994:
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (May 2001). "Creation of genome-wide
2075:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
1190:. It has been implicated in chromatin remodeling and DNA relaxation process required for DNA replication, repair and transcription. The ALC1 comprises ATPase domain and macro domain. On the basis of homology within the ATPase domain, ALC1 belongs to Snf2 family.
1733:
Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N, Vermeulen W, Vrieling H, Mullenders L (October 2012).
1951:
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000).
1864:
Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression".
1922:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
255:
154:
1953:"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"
1247:
About half of the maximum chromatin relaxation, due to action of CHD1L (ALC1), occurs by 10 seconds. This then allows recruitment of the DNA repair enzyme
1399:"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning"
753:
77:
734:
1893:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2078:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1397:
Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998).
2198:
2174:
1379:
1361:
2193:
1640:
Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G, Huet S (December 2016).
1242:
protein, acts very early in DNA repair. Chromatin relaxation occurs rapidly at the site of a DNA damage. This process is initiated by
1113:
241:
1837:
1222:
reprogramming. The CHD1L macro-domain interacts with the PAR moiety of PARylated-PARP1 to facilitate early-stage reprogramming and
1120:
218:
1456:
1348:
1327:
1344:
1843:
1537:
Jiang BH, Chen WY, Li HY, Chien Y, Chang WC, Hsieh PC, Wu P, Chen CY, Song HY, Chien CS, Sung YJ, Chiou SH (October 2015).
140:
115:
1238:
To allow the critical cellular process of DNA repair, the chromatin must be remodeled at sites of damage. CHD1L (ALC1) a
1323:
57:
1285:
254:
153:
1268:
247:
146:
2167:
48:, ALC1, CHDL, chromodomain helicase DNA binding protein 1-like, chromodomain helicase DNA binding protein 1 like
1292:
1280:
1256:
798:
65:
1539:"CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming"
1642:"The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage"
779:
2032:
Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG (June 2005).
2160:
1410:
1239:
1211:
129:
44:
1849:
1295:
a disturbance occurs, which leads to increased DNA breaks. The role of CHD1L is similar to that of
1227:
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1694:"PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites"
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2012:
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1735:"PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1"
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1501:
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492:
37:
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Haince JF, McDonald D, Rodrigue A, Déry U, Masson JY, Hendzel MJ, Poirier GG (January 2008).
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1472:"Identification of multiple distinct Snf2 subfamilies with conserved structural motifs"
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1588:"The chromatin remodeling factor Chd1l is required in the preimplantation embryo"
93:
1384:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1366:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1260:
1403:
Proceedings of the
National Academy of Sciences of the United States of America
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in stem cells. It appears that CHD1L expression is vital for early events in
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1995:
protein expression libraries using random activation of gene expression".
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Snider AC, Leong D, Wang QT, Wysocka J, Yao MW, Scott MP (February 2013).
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1968:
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1457:"Entrez Gene: CHD1L chromodomain helicase DNA binding protein 1-like"
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2128:
2008:
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Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006).
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61:
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nucleotide-excision repair, preincision complex stabilization
1193:
It has 897 amino acids and is approximately 101kDa in size.
1470:
Flaus A, Martin DM, Barton GJ, Owen-Hughes T (2006-05-31).
1784:"Understanding the impact of 1q21.1 copy number variant"
644:
nucleotide-excision repair, preincision complex assembly
317:
2148:
669:
nucleotide-excision repair, DNA incision, 3'-to lesion
649:
nucleotide-excision repair, DNA incision, 5'-to lesion
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repair. CHD1L (ALC1) is also required for repair of
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2034:"The macro domain is an ADP-ribose binding module"
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264:
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1173:Chromodomain-helicase-DNA-binding protein 1-like
664:nucleotide-excision repair, DNA duplex unwinding
16:Protein-coding gene in the species Homo sapiens
1345:GRCm38: Ensembl release 89: ENSMUSG00000028089
1251:, to initiate DNA repair, within 13 seconds.
1218:/PARylation in regulating pluripotency during
2168:
8:
1324:GRCh38: Ensembl release 89: ENSG00000131778
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429:transitional epithelium of urinary bladder
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634:cellular response to DNA damage stimulus
624:nucleotide-excision repair, DNA incision
619:global genome nucleotide-excision repair
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1698:The Journal of Biological Chemistry
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1788:Orphanet Journal of Rare Diseases
1183:that in humans is encoded by the
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114:
509:More reference expression data
471:More reference expression data
367:right hemisphere of cerebellum
1:
2199:Human chromosome 1 gene stubs
1936:10.1016/S0378-1119(97)00411-3
1646:Molecular Biology of the Cell
238:
137:
2147:. You can help Knowledge by
1907:10.1016/0378-1119(94)90802-8
1878:10.1016/0378-1119(94)90293-3
1214:activity and interacts with
2194:Genes on human chromosome 1
1739:The Journal of Cell Biology
1286:1q21.1 duplication syndrome
2215:
2122:
1848:gene details page in the
1269:nucleotide excision repair
1257:homologous recombinational
383:mucosa of transverse colon
1380:"Mouse PubMed Reference:"
1362:"Human PubMed Reference:"
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52:
42:
35:
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26:
21:
2050:10.1038/sj.emboj.7600664
1293:1q21.1 deletion syndrome
1281:1q21.1 deletion syndrome
1114:Chr 1: 147.24 – 147.3 Mb
1658:10.1091/mbc.E16-05-0269
1424:10.1073/pnas.95.14.8175
1121:Chr 3: 97.47 – 97.52 Mb
1801:10.1186/1750-1172-6-54
1711:10.1074/jbc.M706734200
1476:Nucleic Acids Research
1751:10.1083/jcb.201112132
1275:Related gene problems
1228:embryonic development
572:DNA helicase activity
1997:Nature Biotechnology
1842:genome location and
1604:10.1242/bio.20122949
1240:chromatin remodeling
1212:chromatin remodeling
659:DNA duplex unwinding
654:chromatin remodeling
232:Chromosome 3 (mouse)
130:Chromosome 1 (human)
1850:UCSC Genome Browser
1415:1998PNAS...95.8175M
433:seminiferous tubule
371:right lobe of liver
2135:This article on a
2094:10.1101/gr.4039406
1782:Harvard C (2011).
1488:10.1093/nar/gkl295
799:ENSMUSG00000028089
612:Biological process
581:Cellular component
557:hydrolase activity
542:nucleotide binding
535:Molecular function
375:anterior pituitary
2156:
2155:
1969:10.1101/gr.140200
1652:(24): 3791–3799.
1555:10.1002/stem.2116
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94:CHD1L - orthologs
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2038:The EMBO Journal
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1482:(10): 2887–905.
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982:RefSeq (protein)
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449:primitive streak
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411:Top expressed in
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349:Top expressed in
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2082:Genome Research
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2044:(11): 1911–20.
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1993:
1963:(10): 1546–60.
1957:Genome Research
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1930:(1–2): 149–56.
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1857:Further reading
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1704:(2): 1197–208.
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1549:(10): 2961–72.
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1409:(14): 8175–80.
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1301:Werner syndrome
1277:
1255:is involved in
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1161:View/Edit Mouse
1156:View/Edit Human
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1109:Location (UCSC)
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552:protein binding
547:ATPase activity
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208:Gene location (
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1831:External links
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1862:
1861:
1856:
1851:
1847:
1846:
1841:
1840:
1835:
1834:
1830:
1821:
1817:
1812:
1807:
1802:
1797:
1793:
1789:
1785:
1778:
1775:
1770:
1766:
1761:
1756:
1752:
1748:
1745:(2): 235–49.
1744:
1740:
1736:
1729:
1726:
1721:
1717:
1712:
1707:
1703:
1699:
1695:
1688:
1686:
1682:
1677:
1673:
1668:
1663:
1659:
1655:
1651:
1647:
1643:
1636:
1634:
1632:
1628:
1623:
1619:
1614:
1609:
1605:
1601:
1598:(2): 121–31.
1597:
1593:
1589:
1582:
1579:
1574:
1570:
1565:
1560:
1556:
1552:
1548:
1544:
1540:
1533:
1530:
1525:
1521:
1515:
1512:
1507:
1503:
1498:
1493:
1489:
1485:
1481:
1477:
1473:
1466:
1463:
1458:
1452:
1449:
1444:
1440:
1435:
1430:
1425:
1420:
1416:
1412:
1408:
1404:
1400:
1393:
1390:
1385:
1381:
1375:
1372:
1367:
1363:
1357:
1354:
1350:
1346:
1341:
1339:
1337:
1333:
1329:
1325:
1320:
1318:
1316:
1312:
1305:
1303:
1302:
1298:
1294:
1287:
1284:
1282:
1279:
1278:
1274:
1272:
1270:
1266:
1262:
1258:
1254:
1250:
1245:
1241:
1234:In DNA repair
1233:
1231:
1229:
1225:
1221:
1220:developmental
1217:
1213:
1209:
1206:CHD1L, a DNA
1201:
1196:
1194:
1191:
1189:
1186:
1182:
1178:
1174:
1162:
1157:
1153:
1149:
1146:
1142:
1135:
1133:
1130:
1126:
1122:
1118:
1115:
1111:
1107:
1100:
1098:
1092:
1088:
1085:
1079:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1021:
1017:
1011:
1007:
1003:
999:
995:
991:
987:
984:
980:
973:
971:
965:
961:
958:
952:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
884:
880:
876:
872:
868:
864:
860:
857:
855:RefSeq (mRNA)
853:
846:
845:
840:
836:
833:
827:
826:
821:
817:
814:
812:
808:
801:
800:
795:
791:
788:
782:
781:
776:
772:
769:
767:
763:
756:
755:
750:
746:
743:
737:
736:
731:
727:
724:
722:
718:
715:
712:
710:
707:
703:
700:
696:
692:
685:
681:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
604:
601:
599:
596:
594:
591:
589:
586:
585:
583:
580:
579:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
457:Gonadal ridge
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:3|3 F2.2
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2149:expanding it
2141:chromosome 1
2134:
2119:
2088:(1): 55–65.
2085:
2081:
2041:
2037:
2003:(5): 440–5.
2000:
1996:
1960:
1956:
1927:
1923:
1898:
1894:
1869:
1865:
1844:
1838:
1791:
1787:
1777:
1742:
1738:
1728:
1701:
1697:
1649:
1645:
1595:
1592:Biology Open
1591:
1581:
1546:
1542:
1532:
1523:
1514:
1479:
1475:
1465:
1451:
1406:
1402:
1392:
1383:
1374:
1365:
1356:
1290:
1237:
1224:pluripotency
1210:, possesses
1205:
1192:
1184:
1176:
1172:
1171:
1094:
1076:NP_001335395
1072:NP_001335394
1068:NP_001335393
1064:NP_001335392
1060:NP_001335391
1056:NP_001335390
1052:NP_001335389
1048:NP_001335388
1044:NP_001335387
1040:NP_001335386
1036:NP_001335385
1032:NP_001335384
1028:NP_001335383
1024:NP_001335382
1020:NP_001335381
1016:NP_001335380
1013:
998:NP_001243267
994:NP_001243266
990:NP_001243265
967:
941:NM_001348466
937:NM_001348465
933:NM_001348464
929:NM_001348463
925:NM_001348462
921:NM_001348461
917:NM_001348460
913:NM_001348459
909:NM_001348458
905:NM_001348457
901:NM_001348456
897:NM_001348455
893:NM_001348454
889:NM_001348453
886:
879:NM_001348452
875:NM_001348451
871:NM_001256338
867:NM_001256337
863:NM_001256336
842:
823:
797:
778:
752:
733:
713:
708:
441:spermatocyte
437:otic vesicle
425:otic placode
333:
326:
191:147,295,765
178:147,242,654
53:External IDs
598:nucleoplasm
562:ATP binding
453:Paneth cell
387:granulocyte
292:97,517,519
279:97,468,058
31:Identifiers
2188:Categories
1543:Stem Cells
1351:, May 2017
1330:, May 2017
1306:References
629:DNA repair
363:C1 segment
337:(ortholog)
74:HomoloGene
2139:on human
1520:"UniProt"
1299:with the
1265:chromatin
1263:-damaged
1097:NP_080815
1006:NP_078844
1002:NP_004275
970:NM_026539
949:NM_024568
945:NM_004284
699:Orthologs
445:spermatid
82:GeneCards
2112:16344560
2068:15902274
2025:25064683
2017:11329013
1987:11042152
1820:21824431
1769:23045548
1720:18025084
1676:27733626
1622:23429299
1573:26201266
1506:16738128
1347:–
1326:–
1297:helicase
1267:through
1208:helicase
1197:Function
1179:) is an
1145:Wikidata
678:Sources:
2103:1356129
2059:1142602
1944:9373149
1915:8125298
1886:8076819
1811:3180300
1760:3471223
1667:5170603
1613:3575647
1564:4832376
1524:UniProt
1497:1474054
1443:9653160
1411:Bibcode
1349:Ensembl
1328:Ensembl
811:UniProt
766:Ensembl
705:Species
684:QuickGO
603:cytosol
593:nucleus
421:saccule
312:pattern
70:1915308
38:Aliases
2110:
2100:
2066:
2056:
2023:
2015:
1985:
1978:310934
1975:
1942:
1913:
1884:
1836:Human
1818:
1808:
1794:: 54.
1767:
1757:
1718:
1674:
1664:
1620:
1610:
1571:
1561:
1504:
1494:
1441:
1431:
1181:enzyme
1131:search
1129:PubMed
844:Q9CXF7
825:Q86WJ1
721:Entrez
483:BioGPS
391:spleen
170:1q21.1
62:613039
2143:is a
2021:S2CID
1845:CHD1L
1839:CHD1L
1434:20949
1291:With
1253:MRE11
1249:MRE11
1244:PARP1
1216:PARP1
1185:CHD1L
754:68058
714:Mouse
709:Human
680:Amigo
359:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:CHD1L
78:11590
45:CHD1L
22:CHD1L
2145:stub
2137:gene
2108:PMID
2064:PMID
2013:PMID
1983:PMID
1940:PMID
1924:Gene
1911:PMID
1895:Gene
1882:PMID
1866:Gene
1816:PMID
1765:PMID
1716:PMID
1672:PMID
1618:PMID
1569:PMID
1502:PMID
1439:PMID
1188:gene
1177:ALC1
735:9557
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
2098:PMC
2090:doi
2054:PMC
2046:doi
2005:doi
1973:PMC
1965:doi
1932:doi
1928:200
1903:doi
1899:138
1874:doi
1870:146
1806:PMC
1796:doi
1755:PMC
1747:doi
1743:199
1706:doi
1702:283
1662:PMC
1654:doi
1608:PMC
1600:doi
1559:PMC
1551:doi
1492:PMC
1484:doi
1429:PMC
1419:doi
1230:.
288:End
187:End
90:OMA
66:MGI
2190::
2106:.
2096:.
2086:16
2084:.
2080:.
2062:.
2052:.
2042:24
2040:.
2036:.
2019:.
2011:.
2001:19
1999:.
1981:.
1971:.
1961:10
1959:.
1955:.
1938:.
1926:.
1909:.
1897:.
1880:.
1868:.
1814:.
1804:.
1790:.
1786:.
1763:.
1753:.
1741:.
1737:.
1714:.
1700:.
1696:.
1684:^
1670:.
1660:.
1650:27
1648:.
1644:.
1630:^
1616:.
1606:.
1594:.
1590:.
1567:.
1557:.
1547:33
1545:.
1541:.
1522:.
1500:.
1490:.
1480:34
1478:.
1474:.
1437:.
1427:.
1417:.
1407:95
1405:.
1401:.
1382:.
1364:.
1335:^
1314:^
1271:.
1261:UV
682:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2176:e
2169:t
2162:v
2151:.
2114:.
2092::
2070:.
2048::
2027:.
2007::
1989:.
1967::
1946:.
1934::
1917:.
1905::
1888:.
1876::
1852:.
1822:.
1798::
1792:6
1771:.
1749::
1722:.
1708::
1678:.
1656::
1624:.
1602::
1596:2
1575:.
1553::
1526:.
1508:.
1486::
1459:.
1445:.
1421::
1413::
1386:.
1368:.
1175:(
212:)
109:)
92::
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