Knowledge

CHRNA10

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Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)".
2183: 804: 785: 79: 1418: 1200: 2173: 1182: 1255:"The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system" 1385: 243: 1411: 1123:α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown. 1023: 1834: 1822: 1016: 220: 1854: 1731: 1098: 1169: 1148: 1867: 1391: 142: 117: 1165: 1144: 59: 256: 155: 1253:
Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007).
1314:"Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors" 249: 148: 1889: 1846: 1689: 1403: 1903: 1442: 1378: 849: 67: 830: 2090: 2178: 1438: 131: 1325: 1266: 1105: 46: 1374: 2103: 1397: 976: 972: 946: 921: 917: 1906: 1641: 1450: 91: 980: 925: 558:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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detection of mechanical stimulus involved in sensory perception of sound
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This nAchR subunit is required for the normal function of the
1097:. The protein encoded by this gene is a subunit of certain 1116:
RgIA has been shown to be analgesic in an animal model of
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positive regulation of cytosolic calcium ion concentration
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integral component of postsynaptic specialization membrane
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acetylcholine-gated cation-selective channel activity
484: 2102: 2089: 2049: 1984: 1914: 1902: 1880: 1730: 1680: 1506: 1458: 1449: 994: 965: 939: 910: 1161: 1159: 1157: 1140: 1138: 1136: 266: 165: 50:, cholinergic receptor nicotinic alpha 10 subunit 1076:Neuronal acetylcholine receptor subunit alpha-10 543:extracellular ligand-gated ion channel activity 16:Protein-coding gene in the species Homo sapiens 1166:GRCm38: Ensembl release 89: ENSMUSG00000066279 1419: 685:regulation of postsynaptic membrane potential 8: 705:negative regulation of ERK1 and ERK2 cascade 1145:GRCh38: Ensembl release 89: ENSG00000129749 665:regulation of cell population proliferation 2099: 1911: 1455: 1426: 1412: 1404: 745: 510: 307: 206: 103: 1377:at the U.S. National Library of Medicine 1347: 1337: 1288: 1278: 553:transmembrane signaling receptor activity 1132: 1084:cholinergic receptor nicotinic alpha 10 20: 624:integral component of plasma membrane 271: 232: 227: 170: 129: 124: 7: 670:calcium ion transmembrane transport 991: 962: 936: 907: 885: 866: 840: 821: 795: 776: 650:synaptic transmission, cholinergic 489: 407: 345: 324: 14: 2184:Nicotinic acetylcholine receptors 1099:nicotinic acetylcholine receptors 1090:that in humans is encoded by the 690:excitatory postsynaptic potential 715:regulation of membrane potential 255: 248: 242: 219: 154: 147: 141: 116: 710:chemical synaptic transmission 574:integral component of membrane 473:More reference expression data 397:right hemisphere of cerebellum 1: 240: 139: 2174:Genes on human chromosome 11 1318:Proc. Natl. Acad. Sci. U.S.A 1259:Proc. Natl. Acad. Sci. U.S.A 700:ion transmembrane transport 2200: 1396:gene details page in the 538:signaling receptor binding 381:mucosa of transverse colon 1986:Voltage- and ligand-gated 1443:ligand-gated ion channels 1201:"Mouse PubMed Reference:" 1183:"Human PubMed Reference:" 1062: 1057: 1053: 1046: 1030: 1024:Chr 7: 101.76 – 101.77 Mb 1011: 998: 969: 958: 943: 914: 903: 892: 888: 873: 869: 860: 847: 843: 828: 824: 815: 802: 798: 783: 779: 770: 755: 748: 744: 728: 513: 509: 497: 492: 483: 470: 439:quadriceps femoris muscle 419: 410: 357: 348: 318: 310: 306: 289: 276: 239: 218: 209: 205: 188: 175: 138: 115: 106: 102: 57: 54: 44: 37: 32: 28: 23: 1379:Medical Subject Headings 528:calcium channel activity 1732:Nicotinic acetylcholine 1339:10.1073/pnas.0608715103 1280:10.1073/pnas.0708545105 675:inner ear morphogenesis 1375:CHRNA10+protein,+human 1232:10.1006/geno.2000.6503 1017:Chr 11: 3.67 – 3.67 Mb 720:nervous system process 443:skeletal muscle tissue 1439:cell surface receptor 1108:which is part of the 680:calcium ion transport 584:postsynaptic membrane 393:cerebellar hemisphere 132:Chromosome 11 (human) 2104:Purinergic receptors 1390:genome location and 1106:olivocochlear system 533:ion channel activity 361:gastrocnemius muscle 234:Chromosome 7 (mouse) 1398:UCSC Genome Browser 1330:2006PNAS..10317880V 1271:2007PNAS..10420594V 695:signal transduction 614:cholinergic synapse 389:right lobe of liver 96:CHRNA10 - orthologs 1872:β1δε - Muscle type 1451:Cys-loop receptors 850:ENSMUSG00000066279 638:Biological process 567:Cellular component 521:Molecular function 2161: 2160: 2157: 2156: 2085: 2084: 1916:Ligand-gated only 1898: 1897: 1078:, also known as 1073: 1072: 1069: 1068: 1042: 1041: 1007: 1006: 988: 987: 954: 953: 933: 932: 899: 898: 882: 881: 856: 855: 837: 836: 811: 810: 792: 791: 740: 739: 629:neuron projection 505: 504: 501: 500: 479: 478: 466: 465: 404: 403: 302: 301: 201: 200: 2191: 2100: 1912: 1456: 1428: 1421: 1414: 1405: 1362: 1361: 1351: 1341: 1309: 1303: 1302: 1292: 1282: 1250: 1244: 1243: 1215: 1209: 1208: 1197: 1191: 1190: 1179: 1173: 1163: 1152: 1142: 1055: 1054: 1026: 1019: 1002: 992: 983: 963: 959:RefSeq (protein) 949: 937: 928: 908: 886: 867: 841: 822: 796: 777: 746: 511: 490: 475: 415: 413:Top expressed in 408: 353: 351:Top expressed in 346: 325: 308: 298: 285: 274: 259: 252: 246: 235: 223: 207: 197: 184: 173: 158: 151: 145: 134: 120: 104: 98: 49: 42: 21: 2199: 2198: 2194: 2193: 2192: 2190: 2189: 2188: 2164: 2163: 2162: 2153: 2081: 2075: 2067: 2045: 1980: 1894: 1876: 1871: 1863:- Ganglion type 1862: 1858: 1850: 1842: 1838: 1830: 1826: 1726: 1717: 1709: 1701: 1693: 1676: 1670: 1662: 1654: 1645: 1615: 1607: 1599: 1591: 1583: 1575: 1567: 1559: 1551: 1543: 1535: 1527: 1519: 1502: 1471: 1445: 1432: 1371: 1366: 1365: 1324:(47): 17880–4. 1311: 1310: 1306: 1265:(51): 20594–9. 1252: 1251: 1247: 1217: 1216: 1212: 1199: 1198: 1194: 1181: 1180: 1176: 1164: 1155: 1143: 1134: 1129: 1110:auditory system 1064:View/Edit Mouse 1059:View/Edit Human 1022: 1015: 1012:Location (UCSC) 1000: 979: 975: 971: 945: 924: 920: 916: 831:ENSG00000129749 724: 633: 594:plasma membrane 562: 471: 462: 457: 453: 449: 445: 441: 437: 433: 431:muscle of thigh 429: 425: 411: 400: 395: 391: 387: 383: 379: 375: 371: 367: 365:muscle of thigh 363: 349: 293: 280: 272: 262: 261: 260: 253: 233: 210:Gene location ( 192: 179: 171: 161: 160: 159: 152: 130: 107:Gene location ( 58: 45: 38: 17: 12: 11: 5: 2197: 2195: 2187: 2186: 2181: 2176: 2166: 2165: 2159: 2158: 2155: 2154: 2152: 2151: 2150: 2149: 2144: 2139: 2134: 2129: 2124: 2119: 2108: 2106: 2097: 2095:gated channels 2087: 2086: 2083: 2082: 2080: 2079: 2078: 2077: 2073: 2069: 2065: 2055: 2053: 2047: 2046: 2044: 2043: 2042: 2041: 2036: 2031: 2026: 2021: 2016: 2011: 2006: 2001: 1990: 1988: 1982: 1981: 1979: 1978: 1977: 1976: 1971: 1966: 1961: 1956: 1946: 1940: 1935: 1930: 1920: 1918: 1909: 1900: 1899: 1896: 1895: 1893: 1892: 1890:Zinc-activated 1886: 1884: 1878: 1877: 1875: 1874: 1869: 1865: 1860: 1856: 1852: 1848: 1844: 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1119: 1115: 1111: 1107: 1102: 1100: 1096: 1093: 1089: 1085: 1081: 1077: 1065: 1060: 1056: 1052: 1049: 1045: 1038: 1036: 1033: 1029: 1025: 1021: 1018: 1014: 1010: 1003: 997: 993: 990: 984: 982: 978: 974: 968: 964: 961: 957: 950: 948: 942: 938: 935: 929: 927: 923: 919: 913: 909: 906: 904:RefSeq (mRNA) 902: 895: 891: 887: 884: 878: 877: 872: 868: 865: 863: 859: 852: 851: 846: 842: 839: 833: 832: 827: 823: 820: 818: 814: 807: 806: 801: 797: 794: 788: 787: 782: 778: 775: 773: 769: 766: 763: 761: 758: 754: 751: 747: 743: 736: 732: 727: 721: 718: 716: 713: 711: 708: 706: 703: 701: 698: 696: 693: 691: 688: 686: 683: 681: 678: 676: 673: 671: 668: 666: 663: 661: 658: 656: 655:ion transport 653: 651: 648: 646: 643: 642: 640: 637: 636: 630: 627: 625: 622: 620: 617: 615: 612: 610: 609:cell junction 607: 605: 602: 600: 597: 595: 592: 590: 587: 585: 582: 580: 577: 575: 572: 571: 569: 566: 565: 559: 556: 554: 551: 549: 546: 544: 541: 539: 536: 534: 531: 529: 526: 525: 523: 520: 519: 516: 515:Gene ontology 512: 508: 496: 491: 488: 486: 482: 474: 469: 458: 454: 450: 446: 442: 438: 435:muscle tissue 434: 430: 426: 422: 421: 418: 414: 409: 406: 396: 392: 388: 384: 380: 376: 372: 368: 364: 360: 359: 356: 352: 347: 344: 343: 340: 338: 334: 332: 331: 327: 326: 323: 321: 317: 313: 309: 305: 297: 292: 288: 284: 279: 269: 265: 258: 251: 245: 238: 230: 226: 222: 217: 213: 208: 204: 196: 191: 187: 183: 178: 168: 164: 157: 150: 144: 137: 133: 127: 123: 119: 114: 110: 105: 101: 97: 93: 89: 85: 81: 77: 73: 69: 65: 61: 53: 48: 41: 36: 31: 27: 22: 19: 2179:Ion channels 2094: 2058: 2050: 1985: 1915: 1881: 1819: 1782: 1739: 1392: 1386: 1321: 1317: 1307: 1262: 1258: 1248: 1223: 1219: 1213: 1204: 1195: 1186: 1177: 1122: 1118:nerve injury 1103: 1091: 1083: 1079: 1075: 1074: 999: 977:NP_001289964 973:NP_001289963 970: 947:NM_001081424 944: 922:NM_001303035 918:NM_001303034 915: 893: 874: 848: 829: 803: 784: 764: 759: 451:spermatocyte 335: 328: 294:101,766,035 281:101,760,473 55:External IDs 18: 1435:Ion channel 377:granulocyte 273:7|7 E2 33:Identifiers 2168:Categories 1907:glutamates 1904:Ionotropic 1820:pentamers: 1172:, May 2017 1151:, May 2017 1127:References 579:perikaryon 447:blastocyst 339:(ortholog) 193:3,671,384 180:3,665,587 76:HomoloGene 1740:monomers: 1114:conotoxin 1101:(nAchR). 981:NP_065135 926:NM_020402 750:Orthologs 459:esophagus 84:GeneCards 2051:‘Orphan’ 1358:17101979 1299:18077337 1240:11350119 1220:Genomics 1168:– 1147:– 1080:nAChRα10 1048:Wikidata 729:Sources: 589:membrane 373:testicle 1949:Kainate 1682:Glycine 1393:CHRNA10 1387:CHRNA10 1349:1635975 1326:Bibcode 1290:2154476 1267:Bibcode 1170:Ensembl 1149:Ensembl 1092:CHRNA10 1088:protein 1086:, is a 862:UniProt 817:Ensembl 756:Species 735:QuickGO 599:synapse 314:pattern 172:11p15.4 88:CHRNA10 72:3609260 47:CHRNA10 40:Aliases 24:CHRNA10 1384:Human 1381:(MeSH) 1356:  1346:  1297:  1287:  1238:  1120:pain. 1034:search 1032:PubMed 876:Q9GZZ6 805:504186 772:Entrez 485:BioGPS 423:embryo 64:606372 786:57053 765:Mouse 760:Human 731:Amigo 385:blood 369:gonad 337:Mouse 330:Human 277:Start 212:Mouse 176:Start 109:Human 80:56886 2059:GluD 1994:NMDA 1924:AMPA 1882:Zinc 1868:(α1) 1859:(β4) 1855:(α1) 1847:(α7) 1839:(β2) 1835:(α4) 1827:(β4) 1823:(α3) 1642:GABA 1516:GABA 1508:GABA 1468:5-HT 1354:PMID 1295:PMID 1236:PMID 1095:gene 1082:and 604:axon 320:Bgee 268:Band 229:Chr. 167:Band 126:Chr. 60:OMIM 2112:P2X 2091:ATP 2039:L1B 2034:L1A 1783:α10 1344:PMC 1334:doi 1322:103 1285:PMC 1275:doi 1263:104 1228:doi 1001:n/a 894:n/a 493:n/a 455:lip 290:End 189:End 92:OMA 68:MGI 2170:: 2029:3B 2024:3A 2019:2D 2014:2C 2009:2B 2004:2A 1803:β4 1798:β3 1793:β2 1788:β1 1778:α9 1773:α7 1768:α6 1763:α5 1758:α4 1753:α3 1748:α2 1743:α1 1646:-ρ 1441:: 1437:, 1352:. 1342:. 1332:. 1320:. 1316:. 1293:. 1283:. 1273:. 1261:. 1257:. 1234:. 1224:73 1222:. 1203:. 1185:. 1156:^ 1135:^ 733:/ 296:bp 283:bp 195:bp 182:bp 90:; 86:: 82:; 78:: 74:; 70:: 66:; 62:: 2147:7 2142:6 2137:5 2132:4 2127:3 2122:2 2117:1 2093:- 2074:2 2072:δ 2066:1 2064:δ 1999:1 1974:5 1969:4 1964:3 1959:2 1954:1 1945:) 1943:4 1938:3 1933:2 1928:1 1926:( 1870:2 1861:3 1857:2 1849:5 1841:3 1837:2 1829:3 1825:2 1813:ε 1808:δ 1722:β 1716:4 1714:α 1708:3 1706:α 1700:2 1698:α 1692:1 1690:α 1669:3 1667:ρ 1661:2 1659:ρ 1653:1 1651:ρ 1644:A 1635:θ 1630:π 1625:ε 1620:δ 1614:3 1612:γ 1606:2 1604:γ 1598:1 1596:γ 1590:3 1588:β 1582:2 1580:β 1574:1 1572:β 1566:6 1564:α 1558:5 1556:α 1550:4 1548:α 1542:3 1540:α 1534:2 1532:α 1526:1 1524:α 1518:A 1496:E 1491:D 1486:C 1481:B 1476:A 1470:3 1427:e 1420:t 1413:v 1400:. 1360:. 1336:: 1328:: 1301:. 1277:: 1269:: 1242:. 1230:: 1207:. 1189:. 214:) 111:) 94::

Index

Aliases
CHRNA10
OMIM
606372
MGI
3609260
HomoloGene
56886
GeneCards
CHRNA10
OMA
CHRNA10 - orthologs
Human
Chromosome 11 (human)
Chr.
Chromosome 11 (human)
Chromosome 11 (human)
Genomic location for CHRNA10
Genomic location for CHRNA10
Band
bp
bp
Mouse
Chromosome 7 (mouse)
Chr.
Chromosome 7 (mouse)
Genomic location for CHRNA10
Genomic location for CHRNA10
Band
bp

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