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1158:
the inner and outer hair cells (OHCs) of the adult cochlea, although expression levels in adult inner hair cells is low. The activation of the alpha9/10 nAChR is via olivocochlear activity, represented by cholinergic efferent synaptic terminals originating from the superior olive region of the brainstem. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.
1157:
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell function and is expressed in both
50:
1658:
Peng H, Ferris RL, Matthews T, et al. (2004). "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes".
1844:
318:
217:
1942:
2630:
1443:
Sgard F, Charpantier E, Bertrand S, et al. (2002). "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit".
1533:
Lustig LR, Peng H (2003). "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene".
2659:
1812:
1572:"Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene"
874:
855:
140:
1837:
1258:
1240:
2649:
2623:
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304:
1830:
1732:"CENTRAL ROLE OF α9 ACETYLCHOLINE RECEPTOR IN COORDINATING KERATINOCYTE ADHESION AND MOTILITY AT THE INITIATION OF EPITHELIALIZATION"
1154:α9 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.
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281:
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1359:"Novel Human α9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity"
317:
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2265:
310:
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2108:
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2322:
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919:
128:
1617:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
47:
1295:"Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors"
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1482:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
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987:
633:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006).
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1263:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1245:
National Center for
Biotechnology Information, U.S. National Library of Medicine
473:
1671:
289:
186:
136:
1689:"Generation and annotation of the DNA sequences of human chromosomes 2 and 4"
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detection of mechanical stimulus involved in sensory perception of sound
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111:, HSA243342, NACHRA9, cholinergic receptor nicotinic alpha 9 subunit
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1161:
Selective block of α9α10 nicotinic acetylcholine receptors by the
804:
800:
2140:
1144:
564:
124:
1826:
1280:"Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9"
1480:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1147:. The protein encoded by this gene is a subunit of certain
1730:
Chernyavsky AI, Arredondo J, Vetter DE, Grando SA (2007).
1165:
RgIA has been shown to be analgesic in an animal model of
725:
positive regulation of cytosolic calcium ion concentration
694:
integral component of postsynaptic specialization membrane
1402:"DNA Cloning Using In Vitro Site-Specific Recombination"
380:
2604:
1615:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1687:
Hillier LW, Graves TA, Fulton RS, et al. (2005).
618:
acetylcholine-gated cation-selective channel activity
545:
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1217:
1215:
1198:
1196:
1194:
1570:Valor LM, Castillo M, Ortiz JA, Criado M (2003).
327:
226:
1130:Neuronal acetylcholine receptor subunit alpha-9
608:extracellular ligand-gated ion channel activity
16:Protein-coding gene in the species Homo sapiens
1224:GRCm38: Ensembl release 89: ENSMUSG00000029205
2624:
1838:
755:regulation of postsynaptic membrane potential
8:
775:negative regulation of ERK1 and ERK2 cascade
1203:GRCh38: Ensembl release 89: ENSG00000174343
2631:
2617:
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2330:
1874:
1845:
1831:
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1813:United States National Library of Medicine
815:
580:
368:
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1783:at the U.S. National Library of Medicine
1755:
1712:
1640:
1597:
1587:
1515:
1505:
1425:
1400:Hartley JL, Temple GF, Brasch MA (2001).
1382:
1328:
1318:
628:transmembrane signaling receptor activity
1811:This article incorporates text from the
1274:
1272:
1190:
1357:Nguyen VT, Ndoye A, Grando SA (2000).
18:
664:integral component of plasma membrane
332:
293:
288:
231:
190:
185:
7:
2585:
2583:
745:calcium ion transmembrane transport
679:acetylcholine-gated channel complex
1045:
1024:
998:
977:
955:
936:
910:
891:
865:
846:
550:
468:
406:
385:
14:
2660:Nicotinic acetylcholine receptors
1149:nicotinic acetylcholine receptors
1140:that in humans is encoded by the
760:excitatory postsynaptic potential
613:ligand-gated ion channel activity
2587:
1179:Nicotinic acetylcholine receptor
785:regulation of membrane potential
554:
316:
309:
303:
280:
215:
208:
202:
177:
780:chemical synaptic transmission
654:integral component of membrane
565:More reference expression data
534:More reference expression data
434:olfactory zone of nasal mucosa
1:
1375:10.1016/S0002-9440(10)64651-2
504:vestibular sensory epithelium
301:
200:
2603:. You can help Knowledge by
1486:Proc. Natl. Acad. Sci. U.S.A
1299:Proc. Natl. Acad. Sci. U.S.A
2650:Genes on human chromosome 4
1748:10.1016/j.yexcr.2007.07.011
770:ion transmembrane transport
2681:
2582:
1802:gene details page in the
2405:Voltage- and ligand-gated
1862:ligand-gated ion channels
1672:10.1016/j.lfs.2004.05.031
1259:"Mouse PubMed Reference:"
1241:"Human PubMed Reference:"
1116:
1111:
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446:bronchial epithelial cell
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21:
1785:Medical Subject Headings
603:calcium channel activity
442:tibialis anterior muscle
2151:Nicotinic acetylcholine
1320:10.1073/pnas.0608715103
1078:Chr 5: 66.09 – 66.13 Mb
1071:Chr 4: 40.34 – 40.36 Mb
730:inner ear morphogenesis
2665:Membrane protein stubs
2599:–related article is a
1589:10.1074/jbc.M307043200
1507:10.1073/pnas.242603899
790:nervous system process
334:5 C3.1|5 33.84 cM
45:Human UniProt search:
1858:cell surface receptor
1781:CHRNA9+protein,+human
1535:Cytogenet. Genome Res
715:calcium ion transport
669:postsynaptic membrane
2523:Purinergic receptors
1796:genome location and
1457:10.1124/mol.61.1.150
598:ion channel activity
295:Chromosome 5 (mouse)
193:Chromosome 4 (human)
62:List of PDB id codes
35:Available structures
1804:UCSC Genome Browser
1714:10.1038/nature03466
1705:2005Natur.434..724H
1582:(39): 37249–37255.
1498:2002PNAS...9916899M
1492:(26): 16899–16903.
1311:2006PNAS..10317880V
1305:(47): 17880–17884.
765:signal transduction
689:cholinergic synapse
2291:β1δε - Muscle type
1870:Cys-loop receptors
1815:, which is in the
1633:10.1101/gr.2596504
1627:(10B): 2121–2127.
920:ENSMUSG00000029205
708:Biological process
642:Cellular component
591:Molecular function
438:right uterine tube
157:CHRNA9 - orthologs
2612:
2611:
2580:
2579:
2576:
2575:
2504:
2503:
2335:Ligand-gated only
2317:
2316:
1742:(16): 3542–3555.
1699:(7034): 724–731.
1547:10.1159/000069804
1418:10.1101/gr.143000
1412:(11): 1788–1795.
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699:neuron projection
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2597:membrane protein
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1541:(2–3): 154–159.
1529:
1519:
1509:
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1429:
1396:
1386:
1369:(4): 1377–1391.
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1276:
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1210:
1200:
1132:, also known as
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1021:RefSeq (protein)
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750:cation transport
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474:Top expressed in
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412:Top expressed in
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2282:- Ganglion type
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1350:Further reading
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1118:View/Edit Mouse
1113:View/Edit Human
1076:
1069:
1066:Location (UCSC)
1054:
1033:
1007:
986:
901:ENSG00000174343
794:
703:
684:plasma membrane
637:
623:protein binding
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2514:gated channels
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2309:Zinc-activated
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1879:5-HT/serotonin
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1775:External links
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1666:(3): 263–280.
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1451:(1): 150–159.
1445:Mol. Pharmacol
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373:RNA expression
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55:
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2019:
2013:
2011:
2005:
2003:
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1995:
1989:
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1981:
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1818:
1817:public domain
1814:
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1795:
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1782:
1779:
1778:
1774:
1767:
1763:
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1737:
1736:Exp. Cell Res
1733:
1728:
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1706:
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1690:
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1576:J. Biol. Chem
1573:
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1363:Am. J. Pathol
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1199:
1197:
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1184:
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1110:
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1103:
1099:
1092:
1090:
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1079:
1075:
1072:
1068:
1064:
1057:
1051:
1047:
1044:
1038:
1036:
1030:
1026:
1023:
1019:
1012:
1010:
1004:
1000:
997:
991:
989:
983:
979:
976:
974:RefSeq (mRNA)
972:
965:
961:
957:
954:
948:
947:
942:
938:
935:
933:
929:
922:
921:
916:
912:
909:
903:
902:
897:
893:
890:
888:
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
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843:
839:
836:
833:
831:
828:
824:
821:
817:
813:
806:
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797:
791:
788:
786:
783:
781:
778:
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773:
771:
768:
766:
763:
761:
758:
756:
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751:
748:
746:
743:
741:
740:ion transport
738:
736:
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728:
726:
723:
721:
718:
716:
713:
712:
710:
707:
706:
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695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
659:cell junction
657:
655:
652:
650:
647:
646:
644:
641:
640:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
595:
593:
590:
589:
586:
585:Gene ontology
582:
578:
566:
561:
557:
552:
549:
547:
543:
535:
530:
519:
515:
511:
507:
503:
499:
495:
491:
487:
484:otolith organ
483:
482:
479:
475:
470:
467:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
420:
417:
413:
408:
405:
404:
401:
399:
395:
393:
392:
388:
387:
384:
382:
378:
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370:
366:
358:
353:
349:
345:
340:
330:
326:
319:
312:
306:
299:
291:
287:
283:
278:
274:
269:
265:
257:
252:
248:
244:
239:
229:
225:
218:
211:
205:
198:
194:
188:
184:
180:
175:
171:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
114:
109:
102:
97:
92:
81:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2655:Ion channels
2605:expanding it
2594:
2513:
2477:
2469:
2404:
2334:
2300:
2238:
2196:
2158:
1810:
1809:
1798:
1792:
1739:
1735:
1696:
1692:
1663:
1659:
1624:
1620:
1599:10261/338645
1579:
1575:
1538:
1534:
1489:
1485:
1448:
1444:
1409:
1405:
1366:
1362:
1302:
1298:
1288:
1262:
1253:
1244:
1235:
1167:nerve injury
1160:
1156:
1153:
1141:
1133:
1129:
1128:
1053:
1032:
1009:NM_001081104
1006:
985:
963:
944:
918:
899:
873:
854:
834:
829:
454:skin of limb
396:
389:
116:External IDs
67:
1854:Ion channel
458:skin of leg
430:human penis
355:66,134,669
342:66,092,264
254:40,355,217
241:40,335,333
94:Identifiers
2644:Categories
2326:glutamates
2323:Ionotropic
2239:pentamers:
1621:Genome Res
1406:Genome Res
1230:, May 2017
1209:, May 2017
1185:References
512:blastocyst
400:(ortholog)
137:HomoloGene
2159:monomers:
1163:conotoxin
1151:(nAchR).
1035:NP_060051
988:NM_017581
820:Orthologs
516:spermatid
496:esophagus
145:GeneCards
2470:‘Orphan’
1766:17706194
1723:15815621
1680:15531379
1660:Life Sci
1651:15489334
1608:12860975
1563:30207588
1555:12697997
1526:12477932
1473:42831541
1465:11752216
1436:11076863
1393:11021840
1339:17101979
1226:–
1205:–
1173:See also
1102:Wikidata
799:Sources:
674:membrane
422:testicle
2368:Kainate
2101:Glycine
1757:2682983
1701:Bibcode
1494:Bibcode
1384:1850172
1330:1635975
1307:Bibcode
1228:Ensembl
1207:Ensembl
1138:protein
1136:, is a
1134:nAChRα9
932:UniProt
887:Ensembl
826:Species
805:QuickGO
735:hearing
649:synapse
488:utricle
375:pattern
133:1202403
101:Aliases
1799:CHRNA9
1793:CHRNA9
1790:Human
1787:(MeSH)
1764:
1754:
1721:
1693:Nature
1678:
1649:
1642:528928
1639:
1606:
1561:
1553:
1524:
1517:139241
1514:
1471:
1463:
1434:
1427:310948
1424:
1391:
1381:
1337:
1327:
1169:pain.
1142:CHRNA9
1088:search
1086:PubMed
946:Q9UGM1
875:231252
842:Entrez
546:BioGPS
508:embryo
500:morula
492:thymus
149:CHRNA9
125:605116
108:CHRNA9
22:CHRNA9
2595:This
1559:S2CID
1469:S2CID
856:55584
835:Mouse
830:Human
801:Amigo
450:vulva
426:gonad
398:Mouse
391:Human
338:Start
273:Mouse
237:Start
170:Human
2601:stub
2478:GluD
2413:NMDA
2343:AMPA
2301:Zinc
2287:(α1)
2278:(β4)
2274:(α1)
2266:(α7)
2258:(β2)
2254:(α4)
2246:(β4)
2242:(α3)
2061:GABA
1935:GABA
1927:GABA
1887:5-HT
1762:PMID
1719:PMID
1676:PMID
1647:PMID
1604:PMID
1551:PMID
1522:PMID
1461:PMID
1432:PMID
1389:PMID
1335:PMID
1145:gene
381:Bgee
329:Band
290:Chr.
233:4p14
228:Band
187:Chr.
141:9729
121:OMIM
78:4UY2
74:4UXU
70:4D01
51:RCSB
48:PDBe
2531:P2X
2510:ATP
2458:L1B
2453:L1A
2202:α10
1752:PMC
1744:doi
1740:313
1709:doi
1697:434
1668:doi
1637:PMC
1629:doi
1594:hdl
1584:doi
1580:278
1543:doi
1512:PMC
1502:doi
1453:doi
1422:PMC
1414:doi
1379:PMC
1371:doi
1367:157
1325:PMC
1315:doi
1303:103
1055:n/a
964:n/a
351:End
250:End
153:OMA
129:MGI
41:PDB
2646::
2448:3B
2443:3A
2438:2D
2433:2C
2428:2B
2423:2A
2222:β4
2217:β3
2212:β2
2207:β1
2197:α9
2192:α7
2187:α6
2182:α5
2177:α4
2172:α3
2167:α2
2162:α1
2065:-ρ
1860::
1856:,
1760:.
1750:.
1738:.
1734:.
1717:.
1707:.
1695:.
1691:.
1674:.
1664:76
1662:.
1645:.
1635:.
1625:14
1623:.
1619:.
1602:.
1592:.
1578:.
1574:.
1557:.
1549:.
1539:98
1537:.
1520:.
1510:.
1500:.
1490:99
1488:.
1484:.
1467:.
1459:.
1449:61
1447:.
1430:.
1420:.
1410:10
1408:.
1404:.
1387:.
1377:.
1365:.
1361:.
1333:.
1323:.
1313:.
1301:.
1297:.
1271:^
1261:.
1243:.
1214:^
1193:^
803:/
357:bp
344:bp
256:bp
243:bp
151:;
147::
143:;
139::
135:;
131::
127:;
123::
76:,
72:,
2632:e
2625:t
2618:v
2607:.
2566:7
2561:6
2556:5
2551:4
2546:3
2541:2
2536:1
2512:-
2493:2
2491:δ
2485:1
2483:δ
2418:1
2393:5
2388:4
2383:3
2378:2
2373:1
2364:)
2362:4
2357:3
2352:2
2347:1
2345:(
2289:2
2280:3
2276:2
2268:5
2260:3
2256:2
2248:3
2244:2
2232:ε
2227:δ
2141:β
2135:4
2133:α
2127:3
2125:α
2119:2
2117:α
2111:1
2109:α
2088:3
2086:ρ
2080:2
2078:ρ
2072:1
2070:ρ
2063:A
2054:θ
2049:π
2044:ε
2039:δ
2033:3
2031:γ
2025:2
2023:γ
2017:1
2015:γ
2009:3
2007:β
2001:2
1999:β
1993:1
1991:β
1985:6
1983:α
1977:5
1975:α
1969:4
1967:α
1961:3
1959:α
1953:2
1951:α
1945:1
1943:α
1937:A
1915:E
1910:D
1905:C
1900:B
1895:A
1889:3
1846:e
1839:t
1832:v
1819:.
1806:.
1768:.
1746::
1725:.
1711::
1703::
1682:.
1670::
1653:.
1631::
1610:.
1596::
1586::
1565:.
1545::
1528:.
1504::
1496::
1475:.
1455::
1438:.
1416::
1395:.
1373::
1341:.
1317::
1309::
1282:.
1265:.
1247:.
275:)
172:)
155::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
