309:
286:
183:
208:
560:
315:
214:
2207:
Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Düchler M, et al. (December 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex".
50:
1256:
which are involved in antifungal immunity, but also play important roles in immune responses to other pathogens such as bacteria, viruses and nematodes. As a member of this receptor family, dectin-1 recognizes β-glucans and carbohydrates found in
1170:. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial
2469:
de la Rosa G, Yáñez-Mó M, Samaneigo R, Serrano-Gómez D, Martínez-Muñoz L, Fernández-Ruiz E, et al. (May 2005). "Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation".
1194:. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
1206:(ITAM)-like motif in its intracellular tail (which is involved in cellular activation) and one C-type lectin-like domain (carbohydrate-recognition domain, CRD) in the extracellular region (which recognizes
1269:). Ligand binding induces intracellular signalling via the ITAM-like motif. CLEC7A can induce both Syk dependent or Syk independent pathways. Dimerization of dectin-1 upon ligand binding leads to
2309:
Ebner S, Sharon N, Ben-Tal N (October 2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily".
322:
221:
2090:
Hermanz-Falcón P, Arce I, Roda-Navarro P, Fernández-Ruiz E (2001). "Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells".
2426:"CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells"
2061:
Yokota K, Takashima A, Bergstresser PR, Ariizumi K (July 2001). "Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1".
1203:
1171:
2348:"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment"
2280:
Ahrén IL, Eriksson E, Egesten A, Riesbeck K (November 2003). "Nontypeable
Haemophilus influenzae activates human eosinophils through beta-glucan receptors".
833:
814:
144:
1439:
can evade recognition of β-glucan via CLEC7A on phagocytic cells by secreting an enzyme that removes exposed β-glucans or by masking the β-glucan with
2570:
1540:
1522:
1666:"The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages"
1905:
308:
1100:
1093:
1395:
and others. Recognition of these organisms triggers many protective pathways, such as fungal uptake by phagocytosis and killing via
285:
1561:
2221:
1210:
and endogenous ligands on T cells). The CRD is separated from the membrane by a stalk region. CLEC7A contains putative sites of
1509:
1488:
207:
182:
1911:
1505:
2391:"The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages"
115:, BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A
47:
1253:
1999:
1484:
1399:
generation. Activation of dectin-1 also triggers expression of many protecting antifungal cytokines and chemokines (TNF,
124:
2000:"Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence"
1751:"Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity"
321:
220:
2519:"The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells"
314:
213:
1805:"The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors"
1270:
878:
132:
1178:
from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid
2575:
859:
1580:
Drummond RA, Brown GD (August 2011). "The role of Dectin-1 in the host defence against fungal infections".
2479:
1435:
1249:
1211:
196:
2028:"Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning"
1261:, some bacteria and plants, but may also recognize other unidentified molecules (endogenous ligand on
2136:
111:
2484:
1998:
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, et al. (September 1995).
1917:
1749:
Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, et al. (January 2012).
1072:
1005:
2548:
2505:
2334:
2233:
2160:
2115:
1986:
1664:
Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pomares L, Gordon S, Wong SY (October 2002).
1617:"Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function"
1317:
activation. This transcription factor is responsible for the production of numerous inflammatory
156:
1615:
Brown J, O'Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, et al. (June 2007).
1174:. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked
1076:
1051:
1041:
1037:
1033:
1029:
1025:
1001:
980:
976:
972:
968:
958:
954:
950:
946:
942:
559:
2540:
2497:
2457:
2412:
2377:
2326:
2297:
2268:
2225:
2195:
2152:
2107:
2078:
2049:
2014:
1978:
1949:
1883:
1834:
1780:
1731:
1687:
1646:
1597:
1342:
1274:
104:
40:
2530:
2489:
2447:
2437:
2424:
Mantegazza AR, Barrio MM, Moutel S, Bover L, Weck M, Brossart P, et al. (August 2004).
2402:
2367:
2359:
2318:
2289:
2258:
2217:
2185:
2174:"Characterization of the human beta -glucan receptor and its alternatively spliced isoforms"
2144:
2127:
Brown GD, Gordon S (September 2001). "Immune recognition. A new receptor for beta-glucans".
2099:
2070:
2039:
1970:
1941:
1873:
1865:
1824:
1816:
1770:
1762:
1721:
1677:
1636:
1628:
1589:
1373:
1346:
1258:
401:
332:
276:
231:
152:
1309:(CBM) signaling complex. This signaling complex in turn triggers downstream recruitment of
376:
734:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
2517:
Willment JA, Marshall AS, Reid DM, Williams DL, Wong SY, Gordon S, Brown GD (May 2005).
2140:
1961:
Brown GD (January 2006). "Dectin-1: a signalling non-TLR pattern-recognition receptor".
2346:
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003).
1878:
1854:"Flying under the radar: Histoplasma capsulatum avoidance of innate immune recognition"
1853:
1829:
1804:
1775:
1750:
1641:
1616:
1451:
Also operating as a co-stimulatory molecule via recognition of an endogenous ligand on
1350:
1330:
1298:
1229:
1179:
2372:
2347:
2263:
2246:
2074:
1945:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
662:
657:
652:
647:
642:
637:
621:
616:
611:
606:
601:
2564:
2026:
Ariizumi K, Shen GL, Shikano S, Xu S, Ritter R, Kumamoto T, et al. (June 2000).
1820:
1367:
1338:
1334:
588:
2552:
2509:
2338:
2237:
136:
2164:
2119:
1990:
1460:
1456:
1396:
1385:
1379:
1354:
1266:
394:
173:
2389:
Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S (January 2004).
1869:
1766:
160:
2407:
2390:
1682:
1665:
1545:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1527:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1440:
1391:
1207:
2442:
2425:
1365:
CLEC7A has been shown to recognize species of several fungal genera, including
477:
1593:
1233:
1225:
1221:
1187:
293:
190:
140:
2293:
1455:, which leads to cellular activation and proliferation, CLEC7A can bind both
1726:
1709:
1322:
778:
749:
positive regulation of cytokine production involved in inflammatory response
537:
415:
360:
347:
259:
246:
148:
2544:
2501:
2461:
2416:
2381:
2330:
2301:
2272:
2229:
2199:
2190:
2173:
2156:
2111:
2082:
2053:
2044:
2027:
1982:
1953:
1887:
1838:
1784:
1735:
1691:
1650:
1601:
2535:
2518:
2103:
2018:
1140:
1135:
1632:
1408:
1404:
1318:
1314:
1183:
1124:
923:
904:
2493:
2222:
10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9
2452:
2363:
2322:
1175:
1160:
890:
845:
81:
77:
73:
69:
2148:
1452:
1416:
1262:
1237:
1191:
1108:
800:
1974:
1232:. Expression has also been studied on other immune cells including
1420:
1400:
1310:
1306:
1302:
1294:
1290:
1286:
1282:
763:
759:
1424:
1412:
1167:
568:
128:
2245:
Grünebach F, Weck MM, Reichert J, Brossart P (November 2002).
1326:
1278:
2247:"Molecular and functional characterization of human Dectin-1"
1562:"Entrez Gene: CLEC7A C-type lectin domain family 7, member A"
2282:
American
Journal of Respiratory Cell and Molecular Biology
1932:
Drickamer K (October 1999). "C-type lectin-like domains".
724:
positive regulation of protein-containing complex assembly
744:
positive regulation of killing of cells of other organism
1710:"Dectin-1 and Dectin-2 in innate immunity against fungi"
384:
549:
729:
positive regulation of interleukin-1 beta production
1065:
1024:
994:
941:
1501:
1499:
1497:
1480:
1478:
1476:
1202:Dectin-1 is a transmembrane protein containing an
2172:Willment JA, Gordon S, Brown GD (November 2001).
331:
230:
1798:
1796:
1794:
1703:
1701:
1575:
1573:
1571:
1506:GRCm38: Ensembl release 89: ENSMUSG00000079293
1172:immunoreceptor tyrosine-based activation motif
714:pattern recognition receptor signaling pathway
1285:activated, which subsequently phosphorylates
8:
1858:Seminars in Cell & Developmental Biology
1485:GRCh38: Ensembl release 89: ENSG00000172243
1021:
938:
774:
584:
372:
271:
168:
58:
2534:
2483:
2451:
2441:
2406:
2371:
2262:
2189:
2043:
1877:
1828:
1774:
1725:
1681:
1640:
1556:
1554:
1204:immunoreceptor tyrosine-based activation
648:intracellular membrane-bounded organelle
1472:
1153:C-type lectin domain family 7 member A
18:
1934:Current Opinion in Structural Biology
1803:Huysamen C, Brown GD (January 2009).
607:pattern recognition receptor activity
336:
297:
292:
235:
194:
189:
7:
2178:The Journal of Biological Chemistry
2032:The Journal of Biological Chemistry
739:positive regulation of phagocytosis
1708:Saijo S, Iwakura Y (August 2011).
1062:
991:
914:
895:
869:
850:
824:
805:
554:
472:
410:
389:
14:
1423:and IL-6) and the development of
1163:that in humans is encoded by the
1852:Ray SC, Rappleye CA (May 2019).
1821:10.1111/j.1574-6968.2008.01418.x
558:
320:
313:
307:
284:
219:
212:
206:
181:
1582:Current Opinion in Microbiology
689:carbohydrate mediated signaling
2523:European Journal of Immunology
2210:European Journal of Immunology
643:integral component of membrane
569:More reference expression data
538:More reference expression data
1:
2264:10.1016/S0301-472X(02)00928-1
2075:10.1016/S0378-1119(01)00528-5
1946:10.1016/S0959-440X(99)00009-3
1289:that triggers recruitment of
1254:pattern recognition receptors
709:defense response to protozoan
305:
204:
16:Protein-coding gene in humans
2571:Genes on human chromosome 12
2472:Journal of Leukocyte Biology
1870:10.1016/j.semcdb.2018.03.009
1767:10.1016/j.immuni.2011.11.015
2408:10.4049/jimmunol.172.2.1157
1683:10.4049/jimmunol.169.7.3876
1341:. Other responses include:
520:subcutaneous adipose tissue
2592:
2443:10.1182/blood-2004-01-0104
1963:Nature Reviews. Immunology
1916:gene details page in the
1281:. Upon Syk recruitment is
1809:FEMS Microbiology Letters
1594:10.1016/j.mib.2011.07.001
1541:"Mouse PubMed Reference:"
1523:"Human PubMed Reference:"
1139:
1134:
1130:
1123:
1107:
1101:Chr 6: 129.44 – 129.45 Mb
1088:
1069:
1048:
1017:
998:
965:
934:
921:
917:
902:
898:
889:
876:
872:
857:
853:
844:
831:
827:
812:
808:
799:
784:
777:
773:
757:
694:phagocytosis, recognition
587:
583:
566:
557:
548:
535:
484:
475:
422:
413:
383:
375:
371:
354:
341:
304:
283:
274:
270:
253:
240:
203:
180:
171:
167:
122:
119:
109:
102:
97:
66:
61:
44:
39:
34:
30:
26:
21:
2294:10.1165/rcmb.2002-0138OC
1714:International Immunology
1271:tyrosine phosphorylation
1252:are class of signalling
1094:Chr 12: 10.12 – 10.13 Mb
446:tendon of biceps brachii
2251:Experimental Hematology
1447:Co-stimulatory molecule
1250:C-type lectin receptors
1220:CLEC7A is expressed by
462:upper lobe of left lung
2191:10.1074/jbc.M107715200
2045:10.1074/jbc.M909512199
1436:Histoplasma capsulatum
719:innate immune response
516:mucous cell of stomach
500:mesenteric lymph nodes
2536:10.1002/eji.200425725
2395:Journal of Immunology
2104:10.1007/s002510100326
2013:(6547 Suppl): 3–174.
1727:10.1093/intimm/dxr046
1670:Journal of Immunology
1217:in the stalk region.
1215:-linked glycosylation
699:inflammatory response
684:immune system process
197:Chromosome 12 (human)
1910:genome location and
1633:10.1110/ps.072791207
622:carbohydrate binding
299:Chromosome 6 (mouse)
62:List of PDB id codes
35:Available structures
2494:10.1189/jlb.0904529
2141:2001Natur.413...36B
1918:UCSC Genome Browser
1361:Antifungal immunity
1277:and recruitment of
602:MHC protein binding
2364:10.1101/gr.1293003
2323:10.1002/prot.10440
1275:Src family kinases
879:ENSMUSG00000079293
672:Biological process
631:Cellular component
595:Molecular function
504:tibiofemoral joint
438:buccal mucosa cell
161:CLEC7A - orthologs
1343:respiratory burst
1259:fungal cell walls
1150:
1149:
1146:
1145:
1119:
1118:
1084:
1083:
1059:
1058:
1013:
1012:
988:
987:
930:
929:
911:
910:
885:
884:
866:
865:
840:
839:
821:
820:
769:
768:
704:T cell activation
612:metal ion binding
579:
578:
575:
574:
544:
543:
531:
530:
469:
468:
442:periodontal fiber
367:
366:
266:
265:
93:
92:
89:
88:
45:Ortholog search:
2583:
2556:
2538:
2513:
2487:
2465:
2455:
2445:
2420:
2410:
2385:
2375:
2342:
2305:
2276:
2266:
2241:
2216:(12): 3493–503.
2203:
2193:
2184:(47): 43818–23.
2168:
2149:10.1038/35092620
2123:
2086:
2057:
2047:
2038:(26): 20157–67.
2022:
2004:
1994:
1957:
1892:
1891:
1881:
1849:
1843:
1842:
1832:
1800:
1789:
1788:
1778:
1746:
1740:
1739:
1729:
1705:
1696:
1695:
1685:
1661:
1655:
1654:
1644:
1612:
1606:
1605:
1577:
1566:
1565:
1558:
1549:
1548:
1537:
1531:
1530:
1519:
1513:
1503:
1492:
1482:
1353:maturation, and
1347:arachidonic acid
1345:, production of
1132:
1131:
1103:
1096:
1079:
1063:
1054:
1022:
1018:RefSeq (protein)
1008:
992:
983:
939:
915:
896:
870:
851:
825:
806:
775:
679:cell recognition
585:
571:
562:
555:
540:
480:
478:Top expressed in
473:
418:
416:Top expressed in
411:
390:
373:
363:
350:
339:
324:
317:
311:
300:
288:
272:
262:
249:
238:
223:
216:
210:
199:
185:
169:
163:
114:
107:
84:
59:
53:
32:
31:
19:
2591:
2590:
2586:
2585:
2584:
2582:
2581:
2580:
2561:
2560:
2559:
2516:
2485:10.1.1.490.9674
2468:
2423:
2388:
2358:(10): 2265–70.
2352:Genome Research
2345:
2308:
2279:
2257:(11): 1309–15.
2244:
2206:
2171:
2126:
2089:
2060:
2025:
2002:
1997:
1975:10.1038/nri1745
1960:
1931:
1927:
1925:Further reading
1901:
1896:
1895:
1851:
1850:
1846:
1802:
1801:
1792:
1748:
1747:
1743:
1707:
1706:
1699:
1663:
1662:
1658:
1621:Protein Science
1614:
1613:
1609:
1579:
1578:
1569:
1560:
1559:
1552:
1539:
1538:
1534:
1521:
1520:
1516:
1504:
1495:
1483:
1474:
1469:
1449:
1428:
1363:
1357:of the ligand.
1297:, leading to a
1246:
1230:dendritic cells
1200:
1180:dendritic cells
1141:View/Edit Mouse
1136:View/Edit Human
1099:
1092:
1089:Location (UCSC)
1075:
1071:
1050:
1044:
1040:
1036:
1032:
1028:
1004:
1000:
979:
975:
971:
967:
961:
957:
953:
949:
945:
860:ENSG00000172243
753:
667:
658:plasma membrane
626:
617:protein binding
567:
536:
527:
522:
518:
514:
510:
506:
502:
498:
494:
492:right lung lobe
490:
476:
465:
460:
456:
452:
448:
444:
440:
436:
432:
428:
414:
358:
345:
337:
327:
326:
325:
318:
298:
275:Gene location (
257:
244:
236:
226:
225:
224:
217:
195:
172:Gene location (
123:
110:
103:
68:
46:
17:
12:
11:
5:
2589:
2587:
2579:
2578:
2576:C-type lectins
2573:
2563:
2562:
2558:
2557:
2529:(5): 1539–47.
2514:
2478:(5): 699–709.
2466:
2436:(4): 1183–90.
2421:
2401:(2): 1157–62.
2386:
2343:
2306:
2288:(5): 598–605.
2277:
2242:
2204:
2169:
2135:(6851): 36–7.
2124:
2092:Immunogenetics
2087:
2069:(1–2): 51–60.
2058:
2023:
1995:
1958:
1928:
1926:
1923:
1922:
1921:
1900:
1899:External links
1897:
1894:
1893:
1844:
1790:
1741:
1697:
1676:(7): 3876–82.
1656:
1627:(6): 1042–52.
1607:
1567:
1550:
1532:
1514:
1493:
1471:
1470:
1468:
1465:
1448:
1445:
1426:
1362:
1359:
1351:dendritic cell
1265:and ligand on
1245:
1242:
1199:
1196:
1148:
1147:
1144:
1143:
1138:
1128:
1127:
1121:
1120:
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809:
803:
797:
796:
791:
786:
782:
781:
771:
770:
767:
766:
755:
754:
752:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
675:
673:
669:
668:
666:
665:
660:
655:
650:
645:
640:
634:
632:
628:
627:
625:
624:
619:
614:
609:
604:
598:
596:
592:
591:
581:
580:
577:
576:
573:
572:
564:
563:
552:
546:
545:
542:
541:
533:
532:
529:
528:
526:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
482:
481:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
407:
406:
398:
387:
381:
380:
377:RNA expression
369:
368:
365:
364:
356:
352:
351:
343:
340:
335:
329:
328:
319:
312:
306:
302:
301:
296:
290:
289:
281:
280:
268:
267:
264:
263:
255:
251:
250:
242:
239:
234:
228:
227:
218:
211:
205:
201:
200:
193:
187:
186:
178:
177:
165:
164:
121:
117:
116:
108:
100:
99:
95:
94:
91:
90:
87:
86:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2588:
2577:
2574:
2572:
2569:
2568:
2566:
2554:
2550:
2546:
2542:
2537:
2532:
2528:
2524:
2520:
2515:
2511:
2507:
2503:
2499:
2495:
2491:
2486:
2481:
2477:
2473:
2467:
2463:
2459:
2454:
2449:
2444:
2439:
2435:
2431:
2427:
2422:
2418:
2414:
2409:
2404:
2400:
2396:
2392:
2387:
2383:
2379:
2374:
2369:
2365:
2361:
2357:
2353:
2349:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2307:
2303:
2299:
2295:
2291:
2287:
2283:
2278:
2274:
2270:
2265:
2260:
2256:
2252:
2248:
2243:
2239:
2235:
2231:
2227:
2223:
2219:
2215:
2211:
2205:
2201:
2197:
2192:
2187:
2183:
2179:
2175:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2130:
2125:
2121:
2117:
2113:
2109:
2105:
2101:
2098:(4): 288–95.
2097:
2093:
2088:
2084:
2080:
2076:
2072:
2068:
2064:
2059:
2055:
2051:
2046:
2041:
2037:
2033:
2029:
2024:
2020:
2016:
2012:
2008:
2001:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1964:
1959:
1955:
1951:
1947:
1943:
1940:(5): 585–90.
1939:
1935:
1930:
1929:
1924:
1919:
1915:
1914:
1909:
1908:
1903:
1902:
1898:
1889:
1885:
1880:
1875:
1871:
1867:
1863:
1859:
1855:
1848:
1845:
1840:
1836:
1831:
1826:
1822:
1818:
1814:
1810:
1806:
1799:
1797:
1795:
1791:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1745:
1742:
1737:
1733:
1728:
1723:
1720:(8): 467–72.
1719:
1715:
1711:
1704:
1702:
1698:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1660:
1657:
1652:
1648:
1643:
1638:
1634:
1630:
1626:
1622:
1618:
1611:
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1576:
1574:
1572:
1568:
1563:
1557:
1555:
1551:
1546:
1542:
1536:
1533:
1528:
1524:
1518:
1515:
1511:
1507:
1502:
1500:
1498:
1494:
1490:
1486:
1481:
1479:
1477:
1473:
1466:
1464:
1462:
1458:
1454:
1446:
1444:
1442:
1438:
1437:
1432:
1430:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1393:
1388:
1387:
1382:
1381:
1376:
1375:
1370:
1369:
1368:Saccharomyces
1360:
1358:
1356:
1352:
1349:metabolites,
1348:
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1255:
1251:
1243:
1241:
1239:
1235:
1231:
1227:
1223:
1218:
1216:
1214:
1209:
1205:
1197:
1195:
1193:
1189:
1185:
1181:
1177:
1173:
1169:
1166:
1162:
1158:
1154:
1142:
1137:
1133:
1129:
1126:
1122:
1115:
1113:
1110:
1106:
1102:
1098:
1095:
1091:
1087:
1080:
1078:
1074:
1068:
1064:
1061:
1055:
1053:
1047:
1043:
1039:
1035:
1031:
1027:
1023:
1020:
1016:
1009:
1007:
1003:
997:
993:
990:
984:
982:
978:
974:
970:
964:
960:
956:
952:
948:
944:
940:
937:
935:RefSeq (mRNA)
933:
926:
925:
920:
916:
913:
907:
906:
901:
897:
894:
892:
888:
881:
880:
875:
871:
868:
862:
861:
856:
852:
849:
847:
843:
836:
835:
830:
826:
823:
817:
816:
811:
807:
804:
802:
798:
795:
792:
790:
787:
783:
780:
776:
772:
765:
761:
756:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
635:
633:
630:
629:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
590:
589:Gene ontology
586:
582:
570:
565:
561:
556:
553:
551:
547:
539:
534:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
486:
483:
479:
474:
471:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
408:
405:
403:
399:
397:
396:
392:
391:
388:
386:
382:
378:
374:
370:
362:
357:
353:
349:
344:
334:
330:
323:
316:
310:
303:
295:
291:
287:
282:
278:
273:
269:
261:
256:
252:
248:
243:
233:
229:
222:
215:
209:
202:
198:
192:
188:
184:
179:
175:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
118:
113:
106:
101:
96:
85:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2526:
2522:
2475:
2471:
2433:
2429:
2398:
2394:
2355:
2351:
2317:(1): 44–55.
2314:
2310:
2285:
2281:
2254:
2250:
2213:
2209:
2181:
2177:
2132:
2128:
2095:
2091:
2066:
2062:
2035:
2031:
2010:
2006:
1969:(1): 33–43.
1966:
1962:
1937:
1933:
1912:
1906:
1861:
1857:
1847:
1815:(2): 121–8.
1812:
1808:
1761:(1): 32–42.
1758:
1754:
1744:
1717:
1713:
1673:
1669:
1659:
1624:
1620:
1610:
1588:(4): 392–9.
1585:
1581:
1544:
1535:
1526:
1517:
1450:
1434:
1433:
1397:hypochlorite
1390:
1386:Coccidioides
1384:
1380:Pneumocystis
1378:
1372:
1366:
1364:
1355:phagocytosis
1267:mycobacteria
1247:
1219:
1212:
1201:
1164:
1156:
1152:
1151:
1073:NP_001296566
1070:
1049:
1006:NM_001309637
999:
966:
922:
903:
877:
858:
832:
813:
793:
788:
400:
393:
359:129,449,742
346:129,438,554
120:External IDs
67:
2453:11336/43490
1461:CD8 T cells
1392:Penicillium
1234:eosinophils
1226:neutrophils
1222:macrophages
1188:macrophages
663:nucleoplasm
508:bone marrow
488:granulocyte
430:granulocyte
338:6|6 F3
258:10,130,258
245:10,116,777
98:Identifiers
2565:Categories
1512:, May 2017
1491:, May 2017
1467:References
1323:chemokines
450:right lung
404:(ortholog)
141:HomoloGene
2480:CiteSeerX
1864:: 91–98.
1319:cytokines
1208:β-glucans
1198:Structure
1184:monocytes
1077:NP_064392
1052:NP_922945
1042:NP_922941
1038:NP_922940
1034:NP_922939
1030:NP_922938
1026:NP_072092
1002:NM_020008
981:NM_197954
977:NM_197953
973:NM_197952
969:NM_197951
959:NM_197950
955:NM_197949
951:NM_197948
947:NM_197947
943:NM_022570
779:Orthologs
638:cytoplasm
512:left lung
149:GeneCards
2553:20018101
2545:15816015
2510:36603012
2502:15728245
2462:15130945
2417:14707091
2382:12975309
2339:30955198
2331:12945048
2311:Proteins
2302:12689921
2273:12423684
2238:42415487
2230:11745369
2200:11567029
2157:11544516
2112:11491532
2083:11470510
2054:10779524
1983:16341139
1954:10508765
1888:29551572
1839:19025564
1785:22265677
1755:Immunity
1736:21677049
1692:12244185
1651:17473009
1602:21803640
1508:–
1487:–
1441:α-glucan
1325:such as
1244:Function
1157:Dectin-1
1125:Wikidata
758:Sources:
653:membrane
454:appendix
426:monocyte
2165:4368009
2137:Bibcode
2120:9553842
2019:7566098
1991:1310559
1879:6150853
1830:2704933
1776:3477316
1642:2206667
1510:Ensembl
1489:Ensembl
1453:T-cells
1374:Candida
1299:CARD-CC
1263:T-cells
1238:B cells
1192:B cells
1176:glucans
1161:protein
891:UniProt
846:Ensembl
785:Species
764:QuickGO
379:pattern
237:12p13.2
137:1861431
105:Aliases
2551:
2543:
2508:
2500:
2482:
2460:
2415:
2380:
2373:403697
2370:
2337:
2329:
2300:
2271:
2236:
2228:
2198:
2163:
2155:
2129:Nature
2118:
2110:
2081:
2052:
2017:
2007:Nature
1989:
1981:
1952:
1913:CLEC7A
1907:CLEC7A
1904:Human
1886:
1876:
1837:
1827:
1783:
1773:
1734:
1690:
1649:
1639:
1600:
1417:GM-CSF
1165:CLEC7A
1111:search
1109:PubMed
924:V9GXI5
905:Q9BXN2
801:Entrez
550:BioGPS
524:spleen
458:spleen
153:CLEC7A
129:606264
112:CLEC7A
22:CLEC7A
2549:S2CID
2506:S2CID
2430:Blood
2335:S2CID
2234:S2CID
2161:S2CID
2116:S2CID
2003:(PDF)
1987:S2CID
1421:G-CSF
1409:IL-1α
1405:IL-1β
1401:CXCL2
1331:IL-23
1315:NF-κB
1311:TRAF6
1307:MALT1
1303:BCL10
1295:MALT1
1291:BCL10
1287:CARD9
1283:PKC-δ
1159:is a
834:56644
815:64581
794:Mouse
789:Human
760:Amigo
496:blood
434:blood
402:Mouse
395:Human
342:Start
277:Mouse
241:Start
174:Human
145:49606
2541:PMID
2498:PMID
2458:PMID
2413:PMID
2378:PMID
2327:PMID
2298:PMID
2269:PMID
2226:PMID
2196:PMID
2153:PMID
2108:PMID
2079:PMID
2063:Gene
2050:PMID
2015:PMID
1979:PMID
1950:PMID
1884:PMID
1835:PMID
1781:PMID
1732:PMID
1688:PMID
1647:PMID
1598:PMID
1459:and
1413:CCL3
1339:IL-2
1335:IL-6
1321:and
1313:and
1293:and
1248:The
1236:and
1228:and
1190:and
1168:gene
385:Bgee
333:Band
294:Chr.
232:Band
191:Chr.
125:OMIM
82:2CL8
78:2BPH
74:2BPE
70:2BPD
51:RCSB
48:PDBe
2531:doi
2490:doi
2448:hdl
2438:doi
2434:104
2403:doi
2399:172
2368:PMC
2360:doi
2319:doi
2290:doi
2259:doi
2218:doi
2186:doi
2182:276
2145:doi
2133:413
2100:doi
2071:doi
2067:272
2040:doi
2036:275
2011:377
1971:doi
1942:doi
1874:PMC
1866:doi
1825:PMC
1817:doi
1813:290
1771:PMC
1763:doi
1722:doi
1678:doi
1674:169
1637:PMC
1629:doi
1590:doi
1457:CD4
1327:TNF
1279:Syk
1273:by
1155:or
355:End
254:End
157:OMA
133:MGI
41:PDB
2567::
2547:.
2539:.
2527:35
2525:.
2521:.
2504:.
2496:.
2488:.
2476:77
2474:.
2456:.
2446:.
2432:.
2428:.
2411:.
2397:.
2393:.
2376:.
2366:.
2356:13
2354:.
2350:.
2333:.
2325:.
2315:53
2313:.
2296:.
2286:29
2284:.
2267:.
2255:30
2253:.
2249:.
2232:.
2224:.
2214:31
2212:.
2194:.
2180:.
2176:.
2159:.
2151:.
2143:.
2131:.
2114:.
2106:.
2096:53
2094:.
2077:.
2065:.
2048:.
2034:.
2030:.
2009:.
2005:.
1985:.
1977:.
1965:.
1948:.
1936:.
1882:.
1872:.
1862:89
1860:.
1856:.
1833:.
1823:.
1811:.
1807:.
1793:^
1779:.
1769:.
1759:36
1757:.
1753:.
1730:.
1718:23
1716:.
1712:.
1700:^
1686:.
1672:.
1668:.
1645:.
1635:.
1625:16
1623:.
1619:.
1596:.
1586:14
1584:.
1570:^
1553:^
1543:.
1525:.
1496:^
1475:^
1463:.
1443:.
1431:.
1429:17
1419:,
1415:,
1411:,
1407:,
1403:,
1389:,
1383:,
1377:,
1371:,
1337:,
1333:,
1329:,
1240:.
1224:,
1186:,
1182:,
762:/
361:bp
348:bp
260:bp
247:bp
155:;
151::
147:;
143::
139:;
135::
131:;
127::
80:,
76:,
72:,
2555:.
2533::
2512:.
2492::
2464:.
2450::
2440::
2419:.
2405::
2384:.
2362::
2341:.
2321::
2304:.
2292::
2275:.
2261::
2240:.
2220::
2202:.
2188::
2167:.
2147::
2139::
2122:.
2102::
2085:.
2073::
2056:.
2042::
2021:.
1993:.
1973::
1967:6
1956:.
1944::
1938:9
1920:.
1890:.
1868::
1841:.
1819::
1787:.
1765::
1738:.
1724::
1694:.
1680::
1653:.
1631::
1604:.
1592::
1564:.
1547:.
1529:.
1427:h
1425:T
1305:/
1301:/
1213:N
279:)
176:)
159::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
