1281:
disulfide-linked heterodimeric glycoprotein which migrates in SDS-PAGE with an apparent molecular mass of 75-80 kDa. Mature CLU is composed of disulfide-linked α- and β-chains. Although multiple previous publications proposed the existence of N-terminally truncated CLU protein isoforms in different cell compartments, recent work has highlighted the lack of direct evidence for this and shown that the full-length CLU polypeptide, with variable levels of glycosylation (and hence variable apparent mass), can translocate from the ER/Golgi to the cytosol and nucleus during stress.
253:
230:
127:
152:
259:
158:
1404:. Further studies have suggested that people who already have Alzheimer's disease have more clusterin in their blood, and that clusterin levels in blood correlate with faster cognitive decline in individuals with Alzheimer's disease, but have not found that clusterin levels predicted the onset of Alzheimer's disease. In addition to Alzheimer's disease, CLU may be involved in other neurodegenerative diseases such as
1243:
which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. Once internalised by cells, complexes between CLU and misfolded proteins are trafficked to lysosomes where they are degraded. CLU is involved in many
1280:
and a variety of mRNA isoforms can be detected, although most of these are only ever expressed at very low levels (< 0.3% of the total). The full-length mRNA encoding the secreted isoform is by far the dominant species transcribed. Secreted CLU (apolipoprotein J) is an approximately 60 kDa
1473:
As evident by its key roles in cancer development, CLU can serve as a therapeutic target for fighting tumor growth and chemoresistance. Studies revealed that inhibition of CLU resulted in increased effectiveness of chemotherapeutic agents to kill tumor cells. In particular,
1505:
regulation. The chaperone protein then aids hepatitis C viral assembly by stabilizing its core and NS5A units. In addition to the above diseases, CLU has been linked to other conditions resulting from oxidative damage, including aging,
1806:
Lin CC, Tsai P, Sun HY, Hsu MC, Lee JC, Wu IC, Tsao CW, Chang TT, Young KC (Nov 2014). "Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production".
2742:
Boland JM, Folpe AL, Hornick JL, Grogg KL (Aug 2009). "Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications".
2535:
Chou TY, Chen WC, Lee AC, Hung SM, Shih NY, Chen MY (May 2009). "Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway".
2619:
Aigelsreiter A, Janig E, Sostaric J, Pichler M, Unterthor D, Halasz J, Lackner C, Zatloukal K, Denk H (Apr 2009). "Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis".
1308:-independent way. The gene is highly conserved in species, and the protein is widely distributed in many tissues and organs, where it been implicated in a number of biological processes, including
2434:
Ståhl AL, Kristoffersson A, Olin AI, Olsson ML, Roodhooft AM, Proesmans W, Karpman D (Jul 2009). "A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome".
2463:
Balantinou E, Trougakos IP, Chondrogianni N, Margaritis LH, Gonos ES (May 2009). "Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways".
2184:
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. (Oct 2009). "Genome-wide association study identifies variants at CLU and CR1 associated with
Alzheimer's disease".
1304:
proteins, CLU is trafficked through the ER/Golgi before normally being secreted. Within the secretory system, CLU has been suggested to facilitate the folding of secreted proteins in an
3632:
2994:
Tunçdemir M, Ozturk M (Dec 2008). "The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats".
3885:
2887:
Shannan B, Seifert M, Boothman DA, Tilgen W, Reichrath J (Sep 2006). "Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control".
1844:"Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway"
2959:
Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y (Feb 2009).
2815:
Rizzi F, Caccamo AE, Belloni L, Bettuzzi S (May 2009). "Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells".
266:
165:
1289:
Clusterin was first identified in ram rete testis fluid where it was shown to elicit in vitro clustering of rat
Sertoli cells and erythrocytes, hence its name.
2701:"Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex"
1344:
depletion. CLU has been suggested to promote cell survival by a number of means, including inhibition of BAX on the mitochondrial membrane, activation of the
3625:
973:
954:
88:
1454:
features downregulated CLU levels, allowing for increased sensitivity to chemotherapy treatments. Other cancers CLU has been implicated in include
3618:
3075:
4230:
2300:"Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma"
1353:
2333:
Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL (Jun 2009).
2298:
Krumbiegel M, Pasutto F, Mardin CY, Weisschuh N, Paoli D, Gramer E, Zenkel M, Weber BH, Kruse FE, Schlötzer-Schrehardt U, Reis A (Jun 2009).
1602:
2158:
1584:
4473:
2026:"The N-end rule pathway regulates ER stress-induced clusterin release to the cytosol where it directs misfolded proteins for degradation"
252:
3452:
2699:
Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LH, Boothman DA, Gonos ES (Jan 2009).
4448:
1180:
1173:
229:
3492:
2854:"Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells"
2658:"Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression"
3342:
1620:
3641:
1571:
1550:
1416:
1384:
dysfunction and cell death. p53 may also transcriptionally repress secretory CLU to further promote the proapoptotic cascade.
3841:
1397:
1567:
151:
126:
1393:
1345:
1546:
1411:
CLU may promote tumorigenesis by facilitating BAX-KLU70 binding and, consequently, preventing BAX from localizing to the
4054:
2566:
1412:
68:
3999:
3589:
3068:
2237:
Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM (Apr 2011). "Plasma clusterin and the risk of
Alzheimer disease".
1842:
Prochnow, Hans; Gollan, Rene; Rohne, Philipp; Hassemer, Matthias; Koch-Brandt, Claudia; Baiersdörfer, Markus (2013).
3579:
1447:
and NF-κB pathway. Unlike most other cancers, which feature upregulated CLU levels to enhance tumor cell survival,
265:
164:
3542:
3502:
1909:
Kapron, J. T.; Hilliard, G. M.; Lakins, J. N.; Tenniswood, M. P.; West, K. A.; Carr, S. A.; Crabb, J. W. (1997).
1432:
1361:
1249:
258:
157:
3939:
3482:
3457:
3042:
1463:
1018:
76:
2567:"Clusterin expression in cutaneous CD30-positive lymphoproliferative disorders and their histologic simulants"
2656:
Pucci S, Mazzarelli P, Paola M, Sesti F, Fabiola S, Boothman DA, David BA, Spagnoli LG, Luigi SG (Feb 2009).
4264:
3048:
999:
4436:
3053:
4305:
3517:
3061:
1401:
1305:
2116:"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease"
3686:
1515:
1444:
1317:
2405:
Jenne DE, Tschopp J (Apr 1992). "Clusterin: the intriguing guises of a widely expressed glycoprotein".
2075:"Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interactions in vitro"
1328:. Overexpression of secretory CLU can protect cells from apoptosis induced by cellular stress, such as
1855:
140:
1478:, an antisense oligonucleotide that blocks the CLU mRNA transcript, enhanced heat-shock protein 90 (
55:
3649:
3522:
3447:
3334:
3311:
3275:
3247:
1357:
1297:
1240:
2280:
4295:
3663:
3472:
3019:
2912:
2840:
2768:
2644:
2607:
2523:
2262:
2219:
2168:
2006:
1507:
1405:
1293:
100:
59:, AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin
1526:
CLU has been shown to interact with many different protein ligands and several cell receptors.
1156:
1135:
1109:
1088:
2926:"Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer"
4478:
3965:
3547:
3376:
3011:
2982:
2947:
2904:
2875:
2832:
2803:
2760:
2730:
2687:
2636:
2599:
2553:
2515:
2480:
2451:
2422:
2393:
2364:
2321:
2281:"Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's Disease"
2254:
2211:
2145:
2096:
2055:
2047:
1998:
1990:
1948:
1930:
1891:
1873:
1824:
1777:
1723:
1663:
1655:
1459:
1321:
48:
2782:"Clusterin expression correlates with stage and presence of large cells in mycosis fungoides"
2780:
Chandra P, Plaza JA, Zuo Z, Diwan AH, Koeppen H, Duvic M, Medeiros LJ, Prieto VG (Apr 2009).
2114:
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al. (Oct 2009).
2024:
Satapathy, Sandeep; Walker, Holly; Brown, James; Gambin, Yann; Wilson, Mark R. (2023-09-26).
4225:
4184:
4179:
4154:
4144:
4139:
4129:
3929:
3462:
3279:
3232:
3003:
2972:
2937:
2896:
2865:
2824:
2793:
2752:
2720:
2712:
2677:
2669:
2628:
2589:
2581:
2545:
2505:
2472:
2443:
2414:
2385:
2354:
2346:
2311:
2246:
2201:
2193:
2135:
2127:
2086:
2037:
1982:
1938:
1922:
1881:
1863:
1816:
1767:
1759:
1713:
1703:
1647:
1487:
1420:
1349:
345:
276:
220:
175:
4200:
4134:
2494:"Roles of clusterin in progression, chemoresistance and metastasis of human ovarian cancer"
2376:
Trougakos IP, Gonos ES (Nov 2002). "Clusterin/apolipoprotein J in human aging and cancer".
4431:
3654:
3419:
3391:
3307:
2163:
1651:
1511:
1498:
1483:
320:
2335:"Risk of non-Hodgkin lymphoma in association with germline variation in complement genes"
96:
2924:
Shannan B, Seifert M, Leskov K, Willis J, Boothman D, Tilgen W, Reichrath J (Jan 2006).
2476:
1859:
1748:"Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis"
3978:
3973:
3569:
3088:
2725:
2700:
2682:
2657:
2359:
2334:
2140:
2115:
1943:
1910:
1886:
1843:
1772:
1747:
1718:
1691:
1424:
2389:
1443:. Other pathways CLU participates in to downplay apoptosis in tumor cells include the
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
774:
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
577:
572:
556:
551:
546:
541:
536:
4467:
3574:
3562:
3242:
3038:
2844:
2632:
2585:
2418:
2350:
2010:
1911:"Identification and characterization of glycosylation sites in human serum clusterin"
1455:
1313:
1301:
523:
3023:
2916:
2772:
2648:
2527:
2266:
2223:
4334:
4316:
3487:
3399:
3266:
3096:
3092:
2611:
1440:
1436:
1381:
1377:
1365:
1333:
1329:
1257:
338:
117:
2716:
2549:
1482:) inhibitor activity by suppressing the heat-shock response in castrate-resistant
80:
3610:
2756:
2447:
2042:
2025:
1868:
104:
4410:
4278:
3599:
3594:
3584:
3557:
3527:
3512:
3381:
3237:
3227:
3104:
2091:
2074:
1607:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1589:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1494:
864:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
1986:
1820:
421:
4240:
3668:
3427:
3007:
2900:
1448:
1428:
1325:
237:
134:
84:
2798:
2781:
2051:
1994:
1971:"The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis"
1934:
1877:
1659:
1376:
activation, which then skews the proapoptotic:antiapoptotic ratio of present
3988:
3537:
3532:
3507:
3409:
2961:"Genome-wide association study of panic disorder in the Japanese population"
1475:
918:
481:
359:
304:
291:
203:
190:
92:
3015:
2986:
2951:
2942:
2925:
2908:
2879:
2870:
2853:
2836:
2807:
2764:
2734:
2691:
2640:
2603:
2557:
2519:
2484:
2455:
2397:
2368:
2325:
2258:
2215:
2149:
2059:
2002:
1970:
1926:
1895:
1828:
1781:
1763:
1727:
1667:
1635:
2426:
2250:
2100:
1952:
1634:
Wyatt, Amy R.; Yerbury, Justin J.; Ecroyd, Heath; Wilson, Mark R. (2013).
1220:
1215:
17:
4268:
3901:
3893:
3356:
3351:
3346:
3324:
3319:
3297:
3292:
3252:
2594:
2316:
2299:
1467:
1451:
1369:
1341:
1337:
1204:
1063:
1044:
2977:
2960:
2673:
2492:
Wei L, Xue T, Wang J, Chen B, Lei Y, Huang Y, Wang H, Xin X (Aug 2009).
4019:
3906:
3866:
3797:
3792:
3787:
3782:
3777:
3732:
3404:
3287:
3084:
1708:
1502:
1245:
1030:
985:
2828:
2510:
2493:
2206:
1692:"Clusterin: a key player in cancer chemoresistance and its inhibition"
4235:
4210:
4205:
4195:
4159:
4149:
4124:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4039:
4024:
3871:
3836:
3821:
3816:
3811:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3727:
3722:
3717:
3712:
3707:
3477:
3196:
3156:
1253:
1188:
940:
819:
positive regulation of ubiquitin-dependent protein catabolic process
2197:
2131:
4426:
4416:
4406:
4391:
4373:
4368:
4363:
4358:
4290:
4250:
4215:
4189:
4174:
4169:
4164:
4119:
4114:
4069:
4064:
4059:
4029:
4014:
3911:
3880:
3861:
3856:
3851:
3846:
3831:
3826:
3806:
3702:
3695:
3691:
3681:
3676:
3371:
3366:
3211:
3206:
3201:
3191:
3186:
3181:
3161:
3146:
3141:
3126:
3113:
1479:
1309:
1261:
903:
899:
4441:
4421:
4401:
4396:
4346:
4329:
4285:
4273:
4255:
4245:
4044:
4034:
4009:
4004:
3949:
3944:
3552:
3467:
3361:
3176:
3171:
3166:
3151:
3136:
3131:
3121:
1277:
1236:
72:
3614:
3057:
2852:
Liao FT, Lee YJ, Ko JL, Tsai CC, Tseng CJ, Sheu GT (May 2009).
1493:
CLU activity is also involved in infectious diseases, such as
1373:
814:
positive regulation of NF-kappaB transcription factor activity
2378:
859:
positive regulation of intrinsic apoptotic signaling pathway
1419:, CLU functions to regulate ERK 1/2 signaling and matrix
1292:
CLU has functional similarities to members of the small
744:
positive regulation of nitric oxide biosynthetic process
328:
2073:
Fritz IB, Burdzy K, Sétchell B, Blaschuk O (Jun 1983).
839:
positive regulation of tumor necrosis factor production
779:
positive regulation of neurofibrillary tangle assembly
493:
1372:) pathway. Meanwhile, its downregulation allows for
4384:
4315:
4304:
3987:
3964:
3922:
3662:
3648:
3440:
3418:
3390:
3333:
3306:
3274:
3265:
3220:
3112:
3103:
2565:Olsen SH, Ma L, Schnitzer B, Fullen DR (Mar 2009).
1149:
1128:
1102:
1081:
1563:
1561:
1559:
1542:
1540:
1538:
1300:. Unlike most other chaperone proteins, which aid
724:positive regulation of tau-protein kinase activity
709:negative regulation of protein homooligomerization
1400:within the clusterin gene and the risk of having
275:
174:
2304:Investigative Ophthalmology & Visual Science
2159:"Breakthrough Discoveries of Alzheimer's Genes"
1368:, and mediation of the nuclear factor kappa B (
27:Protein-coding gene in the species Homo sapiens
1801:
1799:
1797:
1795:
1793:
1791:
1741:
1739:
1737:
1685:
1683:
1681:
1679:
1677:
1568:GRCm38: Ensembl release 89: ENSMUSG00000022037
1497:. CLU is induced by the stress of hepatitis C
3626:
3069:
1752:Journal of the American Society of Nephrology
1232:In humans, clusterin (CLU) is encoded by the
799:positive regulation of amyloid-beta formation
739:negative regulation of amyloid-beta formation
8:
1969:Satapathy, Sandeep; Wilson, Mark R. (2021).
1636:"Extracellular chaperones and proteostasis"
1547:GRCh38: Ensembl release 89: ENSG00000120885
719:chaperone-mediated protein complex assembly
623:spherical high-density lipoprotein particle
4312:
3659:
3633:
3619:
3611:
3271:
3109:
3076:
3062:
3054:
2745:The American Journal of Surgical Pathology
1396:found a statistical association between a
914:
804:regulation of neuronal signal transduction
519:
316:
215:
112:
3041:at the U.S. National Library of Medicine
2976:
2941:
2869:
2797:
2724:
2681:
2593:
2509:
2358:
2315:
2205:
2139:
2090:
2041:
1942:
1885:
1867:
1771:
1746:Sansanwal P, Li L, Sarwal MM (Mar 2015).
1717:
1707:
1239:on chromosome 8. CLU is an extracellular
869:release of cytochrome c from mitochondria
704:central nervous system myelin maintenance
844:positive regulation of apoptotic process
834:complement activation, classical pathway
638:intracellular membrane-bounded organelle
3382:Structural maintenance of chromosomes 3
1534:
448:paraventricular nucleus of hypothalamus
2786:American Journal of Clinical Pathology
29:
1964:
1962:
1652:10.1146/annurev-biochem-072711-163904
1354:extracellular signal-regulated kinase
794:intrinsic apoptotic signaling pathway
280:
241:
236:
179:
138:
133:
7:
3049:Apolipoproteins and Applied Research
849:regulation of amyloid-beta clearance
2477:10.1016/j.freeradbiomed.2009.01.025
2465:Free Radical Biology & Medicine
1435:, CLU has been observed to promote
769:positive regulation of neuron death
4449:Prokaryotic ubiquitin-like protein
1146:
1125:
1099:
1078:
1054:
1035:
1009:
990:
964:
945:
879:chaperone-mediated protein folding
673:intracellular anatomical structure
498:
416:
354:
333:
25:
3493:Cholesterylester transfer protein
3343:Chondroitin sulfate proteoglycans
2633:10.1111/j.1365-2559.2009.03258.x
2586:10.1111/j.1600-0560.2008.01036.x
2351:10.1111/j.1365-2141.2009.07675.x
557:ubiquitin protein ligase binding
452:dorsomedial hypothalamic nucleus
264:
257:
251:
228:
163:
156:
150:
125:
2858:The Journal of General Virology
2498:International Journal of Cancer
1423:-9 expression to promote tumor
1417:clear cell renal cell carcinoma
1394:genome-wide association studies
1312:transport, membrane recycling,
678:perinuclear region of cytoplasm
3979:Mitochondrial targeting signal
3642:Posttranslational modification
2996:Journal of Molecular Histology
2930:Cell Death and Differentiation
2889:Journal of Molecular Histology
2817:Journal of Cellular Physiology
2574:Journal of Cutaneous Pathology
2407:Trends in Biochemical Sciences
2339:British Journal of Haematology
1975:Trends in Biochemical Sciences
884:antimicrobial humoral response
482:More reference expression data
1:
2717:10.1158/1078-0432.CCR-08-1805
2550:10.1016/j.cellsig.2009.01.008
2390:10.1016/S1357-2725(02)00041-9
1640:Annual Review of Biochemistry
1346:phosphatidylinositol 3-kinase
874:reverse cholesterol transport
809:microglial cell proliferation
714:response to misfolded protein
249:
148:
4055:Ubiquitin-conjugating enzyme
2757:10.1097/PAS.0b013e3181a6d86f
2448:10.1016/j.molimm.2009.04.012
2419:10.1016/0968-0004(92)90325-4
2043:10.1016/j.celrep.2023.113059
1869:10.1371/journal.pone.0075303
1415:to stimulate cell death. In
1413:outer mitochondrial membrane
658:platelet alpha granule lumen
456:Epithelium of choroid plexus
4474:Genes on human chromosome 8
4343:E2 SUMO-conjugating enzyme
4000:Ubiquitin-activating enzyme
3590:Tumor necrosis factor alpha
2092:10.1095/biolreprod28.5.1173
378:paraflocculus of cerebellum
4495:
4326:E1 SUMO-activating enzyme
3580:Thyroxine-binding proteins
1987:10.1016/j.tibs.2021.01.005
1821:10.1016/j.jhep.2014.06.026
1250:neurodegenerative diseases
829:regulation of neuron death
784:microglial cell activation
3543:Serum amyloid P component
3503:Colony-stimulating factor
3008:10.1007/s10735-008-9201-2
2965:Journal of Human Genetics
2901:10.1007/s10735-006-9052-7
2157:Alice Park (2009-09-07).
1603:"Mouse PubMed Reference:"
1585:"Human PubMed Reference:"
1433:epithelial ovarian cancer
1364:expression, promotion of
1362:matrix metallopeptidase-9
1219:
1214:
1210:
1203:
1187:
1168:
1153:
1132:
1121:
1106:
1085:
1074:
1061:
1057:
1042:
1038:
1029:
1016:
1012:
997:
993:
984:
971:
967:
952:
948:
939:
924:
917:
913:
897:
542:misfolded protein binding
522:
518:
506:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
3940:Survival of motor neuron
3483:B-cell activating factor
3458:Alpha 1-antichymotrypsin
3043:Medical Subject Headings
2799:10.1309/AJCPH43ZDVLSOSNB
2705:Clinical Cancer Research
1621:"Entrez Gene: clusterin"
1464:hepatocellular carcinoma
1181:Chr 14: 66.21 – 66.22 Mb
460:dorsal tegmental nucleus
370:external globus pallidus
4306:Ubiquitin-like proteins
4265:Deubiquitinating enzyme
2079:Biology of Reproduction
1696:OncoTargets and Therapy
1352:pathway, modulation of
598:mitochondrial membranes
3518:Membrane glycoproteins
2943:10.1038/sj.cdd.4401779
2871:10.1099/vir.0.007211-0
1927:10.1002/pro.5560061007
1764:10.1681/ASN.2013060577
1380:members, resulting in
1174:Chr 8: 27.6 – 27.61 Mb
854:innate immune response
764:platelet degranulation
613:neurofibrillary tangle
468:ventral tegmental area
282:14 D1|14 34.36 cM
2251:10.1001/jama.2011.381
1809:Journal of Hepatology
1516:myocardial infarction
1445:PI3K/AKT/mTOR pathway
1388:Clinical associations
1318:programmed cell death
1296:family and is thus a
1258:inflammatory diseases
759:protein stabilization
749:complement activation
734:immune system process
653:extracellular exosome
648:endoplasmic reticulum
382:palpebral conjunctiva
243:Chromosome 14 (mouse)
2436:Molecular Immunology
2317:10.1167/iovs.08-2339
1486:, and was tested in
628:extracellular region
608:extracellular matrix
398:middle frontal gyrus
141:Chromosome 8 (human)
3664:Heat shock proteins
3523:Myelin protein zero
3448:Activin and inhibin
3248:Phytohaemagglutinin
2978:10.1038/jhg.2008.17
2674:10.4161/cc.8.3.7652
2538:Cellular Signalling
1860:2013PLoSO...875303P
1402:Alzheimer's disease
1298:molecular chaperone
1276:gene contains nine
1241:molecular chaperone
683:extracellular space
668:cytoplasmic vesicle
593:blood microparticle
3473:Asialoglycoprotein
2442:(11–12): 2236–43.
1709:10.2147/OTT.S58622
1508:glomerulonephritis
1406:Huntington disease
1294:heat shock protein
1019:ENSMUSG00000022037
824:cell morphogenesis
692:Biological process
618:chromaffin granule
566:Cellular component
530:Molecular function
440:epithelium of lens
394:right uterine tube
4461:
4460:
4457:
4456:
3966:Protein targeting
3960:
3959:
3608:
3607:
3548:Sialoglycoprotein
3436:
3435:
3377:Platelet factor 4
3261:
3260:
2864:(Pt 5): 1124–34.
2829:10.1002/jcp.21671
2511:10.1002/ijc.24316
1921:(10): 2120–2133.
1690:Koltai T (2014).
1501:, which disrupts
1460:pancreatic cancer
1230:
1229:
1226:
1225:
1199:
1198:
1164:
1163:
1143:
1142:
1117:
1116:
1096:
1095:
1070:
1069:
1051:
1050:
1025:
1024:
1006:
1005:
980:
979:
961:
960:
909:
908:
754:response to virus
699:apoptotic process
537:chaperone binding
514:
513:
510:
509:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
16:(Redirected from
4486:
4313:
4226:Ubiquitin ligase
3992:(ubiquitylation)
3930:Alpha crystallin
3660:
3635:
3628:
3621:
3612:
3463:Apolipoprotein H
3272:
3233:Intrinsic factor
3110:
3078:
3071:
3064:
3055:
3027:
2990:
2980:
2955:
2945:
2920:
2883:
2873:
2848:
2811:
2801:
2776:
2738:
2728:
2695:
2685:
2652:
2615:
2597:
2571:
2561:
2531:
2513:
2488:
2459:
2430:
2401:
2372:
2362:
2329:
2319:
2285:
2284:
2277:
2271:
2270:
2234:
2228:
2227:
2209:
2181:
2175:
2172:
2167:. Archived from
2153:
2143:
2111:
2105:
2104:
2094:
2070:
2064:
2063:
2045:
2021:
2015:
2014:
1966:
1957:
1956:
1946:
1906:
1900:
1899:
1889:
1871:
1839:
1833:
1832:
1803:
1786:
1785:
1775:
1743:
1732:
1731:
1721:
1711:
1687:
1672:
1671:
1631:
1625:
1624:
1617:
1611:
1610:
1599:
1593:
1592:
1581:
1575:
1565:
1554:
1544:
1488:phase III trials
1427:, invasion, and
1421:metallopeptidase
1392:Two independent
1350:protein kinase B
1212:
1211:
1183:
1176:
1159:
1147:
1138:
1126:
1122:RefSeq (protein)
1112:
1100:
1091:
1079:
1055:
1036:
1010:
991:
965:
946:
915:
729:lipid metabolism
520:
499:
484:
424:
422:Top expressed in
417:
390:Brodmann area 10
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
4494:
4493:
4489:
4488:
4487:
4485:
4484:
4483:
4464:
4463:
4462:
4453:
4380:
4355:E3 SUMO ligase
4319:
4308:
4300:
3991:
3983:
3956:
3918:
3897:
3889:
3667:
3655:protein folding
3653:
3644:
3639:
3609:
3604:
3432:
3414:
3386:
3329:
3302:
3257:
3216:
3099:
3082:
3035:
3030:
2993:
2958:
2923:
2886:
2851:
2814:
2779:
2741:
2698:
2655:
2618:
2569:
2564:
2534:
2491:
2462:
2433:
2404:
2384:(11): 1430–48.
2375:
2332:
2310:(6): 2796–801.
2297:
2293:
2291:Further reading
2288:
2279:
2278:
2274:
2236:
2235:
2231:
2186:Nature Genetics
2183:
2182:
2178:
2156:
2126:(10): 1088–93.
2120:Nature Genetics
2113:
2112:
2108:
2072:
2071:
2067:
2023:
2022:
2018:
1968:
1967:
1960:
1915:Protein Science
1908:
1907:
1903:
1841:
1840:
1836:
1805:
1804:
1789:
1745:
1744:
1735:
1689:
1688:
1675:
1633:
1632:
1628:
1619:
1618:
1614:
1601:
1600:
1596:
1583:
1582:
1578:
1566:
1557:
1545:
1536:
1532:
1524:
1512:atherosclerosis
1499:viral infection
1484:prostate cancer
1441:chemoresistance
1390:
1287:
1270:
1221:View/Edit Mouse
1216:View/Edit Human
1179:
1172:
1169:Location (UCSC)
1155:
1134:
1108:
1087:
1000:ENSG00000120885
893:
687:
588:Golgi apparatus
578:apical dendrite
561:
552:protein binding
547:ATPase activity
480:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
409:
404:
402:Brodmann area 9
400:
396:
392:
388:
384:
380:
376:
374:Achilles tendon
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
105:CLU - orthologs
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
4492:
4490:
4482:
4481:
4476:
4466:
4465:
4459:
4458:
4455:
4454:
4452:
4451:
4445:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4404:
4399:
4394:
4388:
4386:
4382:
4381:
4379:
4378:
4377:
4376:
4371:
4366:
4361:
4352:
4351:
4350:
4349:
4340:
4339:
4338:
4337:
4332:
4323:
4321:
4310:
4302:
4301:
4299:
4298:
4293:
4288:
4282:
4281:
4276:
4271:
4261:
4260:
4259:
4258:
4253:
4248:
4243:
4238:
4233:
4221:
4220:
4219:
4218:
4213:
4208:
4203:
4198:
4193:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4050:
4049:
4048:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
3995:
3993:
3985:
3984:
3982:
3981:
3976:
3974:Signal peptide
3970:
3968:
3962:
3961:
3958:
3957:
3955:
3954:
3953:
3952:
3947:
3937:
3932:
3926:
3924:
3920:
3919:
3917:
3916:
3915:
3914:
3909:
3904:
3899:
3895:
3891:
3887:
3877:
3876:
3875:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3803:
3802:
3801:
3800:
3795:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3699:
3698:
3689:
3684:
3679:
3673:
3671:
3657:
3646:
3645:
3640:
3638:
3637:
3630:
3623:
3615:
3606:
3605:
3603:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3570:Thrombopoietin
3567:
3566:
3565:
3560:
3555:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3444:
3442:
3438:
3437:
3434:
3433:
3431:
3430:
3424:
3422:
3416:
3415:
3413:
3412:
3407:
3402:
3396:
3394:
3388:
3387:
3385:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3339:
3337:
3331:
3330:
3328:
3327:
3322:
3316:
3314:
3304:
3303:
3301:
3300:
3295:
3290:
3284:
3282:
3269:
3263:
3262:
3259:
3258:
3256:
3255:
3250:
3245:
3240:
3235:
3230:
3224:
3222:
3218:
3217:
3215:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3124:
3118:
3116:
3107:
3101:
3100:
3089:glycoconjugate
3083:
3081:
3080:
3073:
3066:
3058:
3052:
3051:
3046:
3034:
3033:External links
3031:
3029:
3028:
2991:
2956:
2921:
2895:(5–7): 183–8.
2884:
2849:
2812:
2777:
2739:
2696:
2653:
2621:Histopathology
2616:
2562:
2532:
2504:(4): 791–806.
2489:
2471:(9): 1267–74.
2460:
2431:
2402:
2373:
2330:
2294:
2292:
2289:
2287:
2286:
2272:
2245:(13): 1322–6.
2229:
2198:10.1038/ng.439
2192:(10): 1094–9.
2176:
2174:
2173:
2171:on 2009-09-09.
2132:10.1038/ng.440
2106:
2085:(5): 1173–88.
2065:
2016:
1981:(8): 652–660.
1958:
1901:
1834:
1787:
1733:
1673:
1626:
1612:
1594:
1576:
1555:
1533:
1531:
1528:
1523:
1520:
1425:cell migration
1389:
1386:
1286:
1283:
1269:
1266:
1228:
1227:
1224:
1223:
1218:
1208:
1207:
1201:
1200:
1197:
1196:
1194:
1192:
1185:
1184:
1177:
1170:
1166:
1165:
1162:
1161:
1151:
1150:
1144:
1141:
1140:
1130:
1129:
1123:
1119:
1118:
1115:
1114:
1104:
1103:
1097:
1094:
1093:
1083:
1082:
1076:
1072:
1071:
1068:
1067:
1059:
1058:
1052:
1049:
1048:
1040:
1039:
1033:
1027:
1026:
1023:
1022:
1014:
1013:
1007:
1004:
1003:
995:
994:
988:
982:
981:
978:
977:
969:
968:
962:
959:
958:
950:
949:
943:
937:
936:
931:
926:
922:
921:
911:
910:
907:
906:
895:
894:
892:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
789:protein import
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
695:
693:
689:
688:
686:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
504:
503:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4491:
4480:
4477:
4475:
4472:
4471:
4469:
4450:
4447:
4446:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4412:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4389:
4387:
4383:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4356:
4354:
4353:
4348:
4345:
4344:
4342:
4341:
4336:
4333:
4331:
4328:
4327:
4325:
4324:
4322:
4320:(SUMOylation)
4318:
4314:
4311:
4307:
4303:
4297:
4294:
4292:
4289:
4287:
4284:
4283:
4280:
4277:
4275:
4272:
4270:
4266:
4263:
4262:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4228:
4227:
4223:
4222:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4057:
4056:
4052:
4051:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4002:
4001:
3997:
3996:
3994:
3990:
3986:
3980:
3977:
3975:
3972:
3971:
3969:
3967:
3963:
3951:
3948:
3946:
3943:
3942:
3941:
3938:
3936:
3933:
3931:
3928:
3927:
3925:
3921:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3892:
3890:
3884:
3883:
3882:
3879:
3878:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3809:
3808:
3805:
3804:
3799:
3796:
3794:
3791:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3705:
3704:
3701:
3700:
3697:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3674:
3672:
3670:
3665:
3661:
3658:
3656:
3651:
3647:
3643:
3636:
3631:
3629:
3624:
3622:
3617:
3616:
3613:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3575:Thyroglobulin
3573:
3571:
3568:
3564:
3563:Glycophorin C
3561:
3559:
3556:
3554:
3551:
3550:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3445:
3443:
3439:
3429:
3426:
3425:
3423:
3421:
3417:
3411:
3408:
3406:
3403:
3401:
3398:
3397:
3395:
3393:
3389:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3344:
3341:
3340:
3338:
3336:
3332:
3326:
3323:
3321:
3318:
3317:
3315:
3313:
3309:
3305:
3299:
3296:
3294:
3291:
3289:
3286:
3285:
3283:
3281:
3277:
3273:
3270:
3268:
3267:Proteoglycans
3264:
3254:
3251:
3249:
3246:
3244:
3243:Peptidoglycan
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3225:
3223:
3219:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3119:
3117:
3115:
3111:
3108:
3106:
3102:
3098:
3097:glycopeptides
3094:
3093:glycoproteins
3090:
3086:
3079:
3074:
3072:
3067:
3065:
3060:
3059:
3056:
3050:
3047:
3044:
3040:
3037:
3036:
3032:
3025:
3021:
3017:
3013:
3009:
3005:
3002:(6): 605–16.
3001:
2997:
2992:
2988:
2984:
2979:
2974:
2970:
2966:
2962:
2957:
2953:
2949:
2944:
2939:
2935:
2931:
2927:
2922:
2918:
2914:
2910:
2906:
2902:
2898:
2894:
2890:
2885:
2881:
2877:
2872:
2867:
2863:
2859:
2855:
2850:
2846:
2842:
2838:
2834:
2830:
2826:
2823:(2): 314–23.
2822:
2818:
2813:
2809:
2805:
2800:
2795:
2791:
2787:
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2751:(8): 1225–9.
2750:
2746:
2740:
2736:
2732:
2727:
2722:
2718:
2714:
2710:
2706:
2702:
2697:
2693:
2689:
2684:
2679:
2675:
2671:
2668:(3): 473–81.
2667:
2663:
2659:
2654:
2650:
2646:
2642:
2638:
2634:
2630:
2627:(5): 561–70.
2626:
2622:
2617:
2613:
2609:
2605:
2601:
2596:
2595:2027.42/73222
2591:
2587:
2583:
2579:
2575:
2568:
2563:
2559:
2555:
2551:
2547:
2544:(5): 704–11.
2543:
2539:
2533:
2529:
2525:
2521:
2517:
2512:
2507:
2503:
2499:
2495:
2490:
2486:
2482:
2478:
2474:
2470:
2466:
2461:
2457:
2453:
2449:
2445:
2441:
2437:
2432:
2428:
2424:
2420:
2416:
2412:
2408:
2403:
2399:
2395:
2391:
2387:
2383:
2379:
2374:
2370:
2366:
2361:
2356:
2352:
2348:
2345:(5): 614–23.
2344:
2340:
2336:
2331:
2327:
2323:
2318:
2313:
2309:
2305:
2301:
2296:
2295:
2290:
2282:
2276:
2273:
2268:
2264:
2260:
2256:
2252:
2248:
2244:
2240:
2233:
2230:
2225:
2221:
2217:
2213:
2208:
2203:
2199:
2195:
2191:
2187:
2180:
2177:
2170:
2166:
2165:
2160:
2155:
2154:
2151:
2147:
2142:
2137:
2133:
2129:
2125:
2121:
2117:
2110:
2107:
2102:
2098:
2093:
2088:
2084:
2080:
2076:
2069:
2066:
2061:
2057:
2053:
2049:
2044:
2039:
2036:(9): 113059.
2035:
2031:
2027:
2020:
2017:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1965:
1963:
1959:
1954:
1950:
1945:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1905:
1902:
1897:
1893:
1888:
1883:
1879:
1875:
1870:
1865:
1861:
1857:
1854:(9): e75303.
1853:
1849:
1845:
1838:
1835:
1830:
1826:
1822:
1818:
1815:(5): 984–93.
1814:
1810:
1802:
1800:
1798:
1796:
1794:
1792:
1788:
1783:
1779:
1774:
1769:
1765:
1761:
1758:(3): 612–25.
1757:
1753:
1749:
1742:
1740:
1738:
1734:
1729:
1725:
1720:
1715:
1710:
1705:
1701:
1697:
1693:
1686:
1684:
1682:
1680:
1678:
1674:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1637:
1630:
1627:
1622:
1616:
1613:
1608:
1604:
1598:
1595:
1590:
1586:
1580:
1577:
1573:
1569:
1564:
1562:
1560:
1556:
1552:
1548:
1543:
1541:
1539:
1535:
1529:
1527:
1521:
1519:
1517:
1513:
1509:
1504:
1500:
1496:
1491:
1489:
1485:
1481:
1477:
1471:
1469:
1465:
1461:
1457:
1456:breast cancer
1453:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1409:
1407:
1403:
1399:
1395:
1387:
1385:
1383:
1382:mitochondrial
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1314:cell adhesion
1311:
1307:
1303:
1302:intracellular
1299:
1295:
1290:
1284:
1282:
1279:
1275:
1267:
1265:
1263:
1259:
1255:
1251:
1247:
1242:
1238:
1235:
1222:
1217:
1213:
1209:
1206:
1202:
1195:
1193:
1190:
1186:
1182:
1178:
1175:
1171:
1167:
1160:
1158:
1152:
1148:
1145:
1139:
1137:
1131:
1127:
1124:
1120:
1113:
1111:
1105:
1101:
1098:
1092:
1090:
1084:
1080:
1077:
1075:RefSeq (mRNA)
1073:
1066:
1065:
1060:
1056:
1053:
1047:
1046:
1041:
1037:
1034:
1032:
1028:
1021:
1020:
1015:
1011:
1008:
1002:
1001:
996:
992:
989:
987:
983:
976:
975:
970:
966:
963:
957:
956:
951:
947:
944:
942:
938:
935:
932:
930:
927:
923:
920:
916:
912:
905:
901:
896:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
696:
694:
691:
690:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
643:mitochondrion
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
4317:SUMO protein
3934:
3497:
3488:4-1BB ligand
3400:Fibromodulin
3105:Mucoproteins
2999:
2995:
2971:(2): 122–6.
2968:
2964:
2933:
2929:
2892:
2888:
2861:
2857:
2820:
2816:
2792:(4): 511–5.
2789:
2785:
2748:
2744:
2711:(1): 48–59.
2708:
2704:
2665:
2661:
2624:
2620:
2580:(3): 302–7.
2577:
2573:
2541:
2537:
2501:
2497:
2468:
2464:
2439:
2435:
2413:(4): 154–9.
2410:
2406:
2381:
2377:
2342:
2338:
2307:
2303:
2275:
2242:
2238:
2232:
2189:
2185:
2179:
2169:the original
2162:
2123:
2119:
2109:
2082:
2078:
2068:
2033:
2030:Cell Reports
2029:
2019:
1978:
1974:
1918:
1914:
1904:
1851:
1847:
1837:
1812:
1808:
1755:
1751:
1699:
1695:
1643:
1639:
1629:
1615:
1606:
1597:
1588:
1579:
1525:
1522:Interactions
1492:
1472:
1437:angiogenesis
1410:
1391:
1378:Bcl-2 family
1366:angiogenesis
1334:radiotherapy
1330:chemotherapy
1291:
1288:
1273:
1271:
1233:
1231:
1154:
1133:
1107:
1086:
1062:
1043:
1017:
998:
972:
953:
933:
928:
633:cell surface
436:ciliary body
406:right testis
344:
337:
64:External IDs
4411:neddylation
3677:Hsp10/GroES
3669:Chaperonins
3600:Vitronectin
3595:Uteroglobin
3585:Transcortin
3558:Glycophorin
3528:Osteonectin
3513:Lactoferrin
3238:Orosomucoid
3228:Haptoglobin
2936:(1): 12–9.
1646:: 295–322.
1495:hepatitis C
386:optic nerve
303:66,218,996
290:66,205,932
202:27,614,700
189:27,596,917
42:Identifiers
4468:Categories
3703:Hsp40/DnaJ
3650:Chaperones
3428:Syndecan 1
2662:Cell Cycle
2207:10281/9031
1702:: 447–56.
1574:, May 2017
1553:, May 2017
1530:References
1449:testicular
1429:metastasis
1356:(ERK) 1/2
1326:cell lysis
1324:-mediated
1322:complement
1248:including
889:cell death
348:(ortholog)
85:HomoloGene
18:CLU (gene)
3989:Ubiquitin
3935:Clusterin
3538:Protein S
3533:Protein C
3508:Hemopexin
3498:Clusterin
3410:Keratocan
3039:Clusterin
2845:206047289
2052:2211-1247
2011:231897964
1995:0968-0004
1935:0961-8368
1878:1932-6203
1660:1545-4509
1476:custirsen
1358:signaling
1268:Structure
1157:NP_038520
1136:NP_001822
1110:NM_013492
1089:NM_001831
919:Orthologs
573:cytoplasm
464:subiculum
93:GeneCards
4479:Proteins
4269:Ataxin 3
3357:Brevican
3352:Neurocan
3347:Aggrecan
3325:Perlecan
3320:Testican
3298:Versican
3293:Biglycan
3253:Ovomucin
3024:11598911
3016:18949565
2987:19165232
2952:16179938
2917:20041580
2909:17048076
2880:19264665
2837:19137541
2808:19289586
2773:24444024
2765:19542874
2735:19118032
2692:19177010
2649:21277859
2641:19413638
2604:19220628
2558:19166932
2528:23162609
2520:19391138
2485:19353783
2456:19446882
2398:12200037
2369:19344414
2326:19182256
2267:36026598
2259:21467285
2224:24530130
2216:19734903
2150:19734902
2060:37660295
2003:33573881
1896:24073260
1848:PLOS ONE
1829:24996046
1782:25071085
1728:24672247
1668:23350744
1570:–
1549:–
1468:melanoma
1452:seminoma
1342:estrogen
1338:androgen
1285:Function
1246:diseases
1205:Wikidata
898:Sources:
603:membrane
444:habenula
4192:(CDC34)
3405:Lumican
3288:Decorin
3085:Protein
2726:4483278
2683:2853871
2612:8915250
2427:1585460
2360:2820509
2283:. 2010.
2141:2845877
2101:6871313
1953:9336835
1944:2143570
1887:3779157
1856:Bibcode
1773:4341467
1719:3964162
1572:Ensembl
1551:Ensembl
1503:glucose
1254:cancers
1031:UniProt
986:Ensembl
925:Species
904:QuickGO
663:nucleus
583:cytosol
323:pattern
49:Aliases
4236:Cullin
3478:Avidin
3157:MUC5AC
3045:(MeSH)
3022:
3014:
2985:
2950:
2915:
2907:
2878:
2843:
2835:
2806:
2771:
2763:
2733:
2723:
2690:
2680:
2647:
2639:
2610:
2602:
2556:
2526:
2518:
2483:
2454:
2425:
2396:
2367:
2357:
2324:
2265:
2257:
2222:
2214:
2148:
2138:
2099:
2058:
2050:
2009:
2001:
1993:
1951:
1941:
1933:
1894:
1884:
1876:
1827:
1780:
1770:
1726:
1716:
1666:
1658:
1514:, and
1466:, and
1320:, and
1260:, and
1191:search
1189:PubMed
1064:Q06890
1045:P10909
941:Entrez
494:BioGPS
181:8p21.1
73:185430
4427:ATG12
4417:FAT10
4407:NEDD8
4392:ISG15
4385:Other
4374:PIAS4
4369:PIAS3
4364:PIAS2
4359:PIAS1
4309:(UBL)
4291:BIRC6
4251:FANCL
3923:Other
3912:TRAP1
3881:Hsp90
3807:Hsp70
3696:GroEL
3692:HSP60
3687:Hsp47
3682:Hsp27
3441:Other
3372:CSPG5
3367:CSPG4
3221:Other
3212:MUC20
3207:MUC19
3202:MUC17
3197:MUC16
3192:MUC15
3187:MUC13
3182:MUC12
3162:MUC5B
3147:MUC3B
3142:MUC3A
3127:CD164
3114:Mucin
3020:S2CID
2913:S2CID
2841:S2CID
2769:S2CID
2645:S2CID
2608:S2CID
2570:(PDF)
2524:S2CID
2263:S2CID
2220:S2CID
2007:S2CID
1480:HSP90
1431:. In
1370:NF-κB
1336:, or
1310:lipid
1278:exons
1262:aging
974:12759
934:Mouse
929:Human
900:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
81:88423
4442:UBL5
4432:FUB1
4422:ATG8
4402:UFM1
4397:URM1
4347:UBC9
4335:SAE2
4330:SAE1
4296:UFC1
4286:ATG3
4279:CYLD
4274:USP6
4256:UBR1
4246:MDM2
4045:SAE1
4040:NAE1
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