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tool used to analyze high-throughput datasets (or small-scale datasets) using protein complex enrichment analysis. The tool uses a protein complex resource as the back end annotation data instead of conventional
44:- or pathway-based annotations. The tool incorporates several useful features in order to provide a comprehensive data-mining environment, including network-based visualization and interactive querying options.
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Neumüller, R.A; Gross, T; Samsonova, A; Vinayagam, A; Buckner, M; Founk, K; Hu, Y; Sharifpoor, S; Rosebrock, AP; Andrews, B; Winston, F; Perrimon, N (Aug 20, 2013).
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Dynamic protein complexes regulated by insulin and epidermal growth factors signaling, including a role of Brahma complex in the cellular response to insulin.
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Evolutionarily conserved molecular complexes that regulate nucleolar size when the complex constituents were targeted by RNA interference.
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Vinayagam, A; Hu, Y; Kulkarni, M; Roesel, C; Sopko, R; Mohr, SE; Perrimon, N (Feb 26, 2013).
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Novel role of endocytosis and vesicle trafficking complexes in Hippo
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Kwon, Y; Vinayagam, A; Sun, X; Dephoure, N; Gygi, S.P; Hong, P; Perrimon, N (2013).
153:"Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses"
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104:"Protein complex-based analysis framework for high-throughput data sets"
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COMPLEAT has been successfully applied to identify:
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202:"The Hippo Signaling Pathway Interactome"
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47:COMPLEAT may be used to analyze
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16:Online bioinformatics tool
169:10.1126/scisignal.2004145
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61:high-throughput datasets
278:Bioinformatics software
218:10.1126/science.1243971
268:Data analysis software
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53:proteomic datasets
157:Science Signaling
108:Science Signaling
35:ool is an online
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