310:
287:
184:
209:
561:
2462:
29:
316:
215:
2447:
1407:
The new ribbon visualization of the secondary structure of coronin-1a. In model A, is the front view of coronin-1a, the secondary structure allows you to clearly see the parallel beta sheets moving towards the bottom of the structure. Model B, is the side view of the protein which shows the turns and
1314:
These protein were named Corona, which is the Latin word for crown, because of the crown-like shape that it forms when making contact with the surface of the cell. Coronin-1a has been the most researched one due to its complexity and intriguing structural components. After research, it was determined
1419:
Coronin-1a was input into
Database of Secondary Structure Program, where the Protein Data Bank database entered and a secondary structure panel is designed where one is clearly able to see the seven repeat that makes the propeller. Also, it displays the amino acid sequence of coronin-1a. The yellow
1367:
Coronin-1a has been found in the cell cortex of macrophages, which are white blood cells, helping with a process called phagocytosis. The model on Figure 3 shows coronin-1a's involvement in macrophages. When the cell is at rest, Coronin-1a is spread out throughout the cytoplasm and the cell cortex.
1387:
Toxoplasma gondii coronin (TgCor) binds to F-actin and it accelerates the actin polymerization process. It also prevents incursions and exits. As well as every other coronin, TgCor is an actin binding protein, it delocalizes to the posterior side of invading parasites and blocks them from leaving.
1318:
Later on, the complementary DNA (cDNA) of coronin-1a was cloned in an expression library, this led to the conclusion that coronin-1a has very similar structure to the beta (β) subunits of the G proteins (Gβ). Therefore, it was established that coronin-1a has five WD motif repeats, and this repeats
1310:
The coronin protein family was discovered in 1991 by
Eugenio L. Hostos. Hostos used a cytoskeletal preparation called the “contracted propeller” that efficiently helped with the purification of cytoskeletal proteins. This technique allowed him to precipitate actomyosin components together with the
2325:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K,
55:
1420:
arrows mean the beta strands, the purple loops are the turns, the black lines means empty meaning that there was no secondary structure assigned, the light pink is 3/10-helix is formed, royal blue line is a bend and finally the red helix signifies the alpha helices.
1379:
The phylogenetic tree of the coronin family it is broad. The same way that coronin-1a helps with the reorganization of the cytoskeleton and dynamic activity with other proteins in vertebrates, Coronin can also be seen in non-vertebrates, for example in
1322:
In the cell, coronin-1a serves as an auxiliary to many cytoskeletal process that involve actin. It was concluded that coronin-1a is known to affect the “cytoskeletal reorganization” as well “actin dynamics” together with other protein.
1315:
that coronin-1a serves as actin binding facilitator when reacted with K-glutamate. The anion K + and glutamate were used because of it similarity to the environment inside the cell, allowing coronin-1a to bind to F-actin.
1334:
The evolutionary coronin subfamilies have been grouped by its similarities and relationships between the different proteins. Coronin-1a (also referenced as CORO1A, Coronin 4 and CRN4) has been found in 19 vertebrates.
1514:
Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Sep 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein".
1909:
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (Dec 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes".
1990:
Grogan A, Reeves E, Keep N, Wientjes F, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (Dec 1997). "Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils".
1302:. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw.
1331:
The coronin family is composed of twelve subfamilies which include: seven subfamilies that fall under vertebrates and five subfamilies that are composed of metazoans, fungi and amoeba.
1347:
Surface representation of TgCor, a thin stick visualization showing protein ligands acetate anion and 2-amino-2-hydroxymethyl-promane-1,3-diolmade using
Molegro Molecular Viewer
323:
222:
1412:
1408:
the coils between the beta sheets. From this pictures we are able to see that the alpha helix and helix strands are concentrated at the bottom of the protein.
2140:
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (Jul 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes".
1400:
1009:
990:
145:
2461:
1355:
Surface representation of TgCor, thin stick visualization, showing 2-amino-2-hydroxymethyl-promane-1,3-diol made using
Molegro Molecular Viewer
2490:
2426:
1834:
1721:
1637:
1496:
1478:
52:
1861:
309:
1678:
1232:
1225:
2214:"Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules"
1360:
1396:
The structure of coronin-1A is made out of five WD repeats, and this motifs repeat seven time forming a propeller like structures.
1352:
1344:
286:
1550:
1368:
Therefore, when a pathogen enters the cell, Coronin-1a binds to phagosomal membrane making sure of the binding and activation of
2171:"Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region"
1465:
1444:
2446:
1756:
Steinmetz MO, Jelesarov I, Matousek WM, Honnappa S, Jahnke W, Missimer JH, Frank S, Alexandrescu AT, Kammerer RA (Apr 2007).
208:
183:
1867:
1461:
1440:
125:
1376:
is inhibited then it allows the initiation of the fusion of phagosomes with lysosome and the killing of mycobacteria.
322:
221:
1363:
Surface representation of TgCor, thin stick visualization, showing acetate anion made using
Molegro Molecular Viewer
315:
214:
1411:
2419:
1054:
133:
1372:, this resulting in a stop of fusion lysosomes with phagosomes. In other words, if coronin-1a is removed and
1035:
2257:"Downregulation of TACO gene transcription restricts mycobacterial entry/survival within human macrophages"
2107:"Two regions responsible for the actin binding of p57, a mammalian coronin family actin-binding protein"
197:
1949:"Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif"
2412:
1769:
2105:
Oku T, Itoh S, Okano M, Suzuki A, Suzuki K, Nakajin S, Tsuji T, Nauseef WM, Toyoshima S (Apr 2003).
112:
1873:
1665:. Subcellular Biochemistry. Vol. 48 (first ed.). New York, N.Y.: Springer. pp. 1–5.
1399:
1204:
1179:
1149:
1124:
2050:
1978:
1935:
1735:
157:
1208:
1183:
1153:
1128:
2392:
2357:
2313:
2278:
2243:
2200:
2157:
2128:
2093:
2042:
2007:
1970:
1927:
1880:
1840:
1830:
1797:
1727:
1717:
1684:
1674:
1643:
1633:
1595:
1532:
105:
45:
2326:
Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
2382:
2347:
2339:
2303:
2268:
2233:
2225:
2190:
2182:
2149:
2118:
2083:
2075:
2032:
1999:
1960:
1919:
1822:
1787:
1777:
1709:
1666:
1625:
1624:. Subcellular Biochemistry. Vol. 48. Madame Curie Bioscience Database. pp. 31–40.
1585:
1577:
1524:
560:
402:
333:
277:
232:
153:
1703:
377:
1773:
28:
2352:
2327:
2238:
2213:
2195:
2170:
2088:
2063:
1947:
Suzuki K, Nishihata J, Arai Y, Honma N, Yamamoto K, Irimura T, Toyoshima S (May 1995).
1792:
1757:
1590:
1565:
2037:
2020:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
2484:
2021:"A coat protein on phagosomes involved in the intracellular survival of mycobacteria"
1965:
1948:
1889:
1581:
589:
2054:
1982:
1939:
1739:
137:
2371:"Coronin function is required for chemotaxis and phagocytosis in human neutrophils"
395:
174:
2273:
2256:
1713:
161:
2387:
2370:
2328:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
2153:
2079:
1826:
1670:
1629:
1501:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1483:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1373:
1369:
2169:
Oku T, Itoh S, Ishii R, Suzuki K, Nauseef WM, Toyoshima S, Tsuji T (Apr 2005).
1762:
Proceedings of the
National Academy of Sciences of the United States of America
478:
1816:
1619:
294:
191:
141:
1923:
1821:. Subcellular Biochemistry. Vol. 48. Landes Bioscience. pp. 56–71.
2229:
2064:"Thrombospondin-1 binds to polyhistidine with high affinity and specificity"
2003:
1782:
1528:
1299:
1298:. It has been implicated in both T-cell mediated immunity and mitochondrial
954:
538:
416:
361:
348:
260:
247:
149:
2396:
2361:
2317:
2282:
2247:
2204:
2161:
2132:
2097:
2046:
1844:
1801:
1731:
1688:
1647:
1599:
2308:
2291:
2011:
1974:
1931:
1536:
1272:
1267:
1256:
1099:
1080:
2212:
Gatfield J, Albrecht I, Zanolari B, Steinmetz MO, Pieters J (Jun 2005).
1566:"Gene expression profiles associated with aging and mortality in humans"
1359:
2343:
2186:
2123:
2106:
1894:
1884:
1351:
1343:
1288:
1066:
1021:
82:
78:
74:
1240:
976:
1815:
McArdle B, Hofmann A (2000). "Coronin structure and implications".
1410:
1403:
Secondary structure model using Visual
Molecular Dynamics software
1398:
1358:
1350:
1342:
1415:
Secondary structure using
Database of Secondary Structure Program
939:
935:
2369:
Yan M, Di Ciano-Oliveira C, Grinstein S, Trimble WS (May 2007).
2062:
Vanguri VK, Wang S, Godyna S, Ranganathan S, Liau G (Apr 2000).
1295:
569:
129:
2408:
2404:
1618:
de Hostos EL (2008). "A brief history of the coronin family".
855:
regulation of release of sequestered calcium ion into cytosol
1879:
Overview of all the structural information available in the
1708:. Subcellular Biochemistry. Vol. 48. pp. 116–23.
2292:"The identification of a new actin-binding region in p57"
2470:: Crystal Structure of Murine Coronin-1: monoclinic form
1551:"Entrez Gene: CORO1A coronin, actin binding protein, 1A"
385:
860:
regulation of actin polymerization or depolymerization
550:
116:, CLABP, CLIPINA, HCORO1, IMD8, TACO, p57, coronin 1A
2019:
Ferrari G, Langen H, Naito M, Pieters J (May 1999).
1197:
1172:
1142:
1117:
521:
dentate gyrus of hippocampal formation granule cell
1702:Pieters J (2000). "Coronin 1 in innate immunity".
1457:
1455:
1453:
1436:
1434:
1432:
332:
231:
1319:seven times forming a propeller like structure.
875:negative regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
1462:GRCm38: Ensembl release 89: ENSMUSG00000030707
895:early endosome to recycling endosome transport
790:homeostasis of number of cells within a tissue
2420:
1564:Kerber RA, O'Brien E, Cawthon RM (Jun 2009).
825:regulation of actin cytoskeleton organization
8:
1441:GRCh38: Ensembl release 89: ENSG00000102879
870:regulation of actin filament polymerization
840:positive regulation of T cell proliferation
2427:
2413:
2405:
1758:"Molecular basis of coiled-coil formation"
1751:
1749:
1661:Rybakin V, Clemen CS, Eichinger L (2008).
950:
585:
373:
272:
169:
63:
2386:
2351:
2307:
2272:
2237:
2194:
2122:
2087:
2036:
1964:
1791:
1781:
1589:
2111:Biological & Pharmaceutical Bulletin
1613:
1611:
1609:
880:positive regulation of T cell activation
2455:: Crystal Structure of Murine Coronin-1
2442:
1428:
795:negative regulation of actin nucleation
18:
820:positive regulation of cell migration
810:nerve growth factor signaling pathway
780:negative regulation of vesicle fusion
618:phosphatidylinositol 3-kinase binding
337:
298:
293:
236:
195:
190:
7:
2290:Liu CZ, Chen Y, Sui SF (Jan 2006).
1194:
1169:
1139:
1114:
1090:
1071:
1045:
1026:
1000:
981:
845:cellular response to interleukin-4
555:
473:
411:
390:
14:
1291:that in humans is encoded by the
850:natural killer cell degranulation
623:protein homodimerization activity
2460:
2445:
1582:10.1111/j.1474-9726.2009.00467.x
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
915:immunological synapse formation
905:actin cytoskeleton organization
1818:The Coronin Family of Proteins
1705:The Coronin Family of Proteins
1663:The Coronin Family of Proteins
1621:The Coronin Family of Proteins
570:More reference expression data
539:More reference expression data
1:
2255:Anand PK, Kaul D (Sep 2005).
2218:Molecular Biology of the Cell
2038:10.1016/S0092-8674(00)80754-0
306:
205:
2491:Genes on human chromosome 16
2274:10.1016/j.femsle.2005.06.056
1966:10.1016/0014-5793(95)00393-N
1714:10.1007/978-0-387-09595-0_11
638:cytoskeletal protein binding
2388:10.4049/jimmunol.178.9.5769
2154:10.1016/j.ygeno.2004.01.011
1827:10.1007/978-0-387-09595-0_6
1671:10.1007/978-0-387-09595-0_1
1630:10.1007/978-0-387-09595-0_4
835:actin filament organization
734:phagocytic vesicle membrane
709:cortical actin cytoskeleton
2507:
1872:gene details page in the
633:myosin heavy chain binding
608:protein C-terminus binding
2440:
2332:Molecular Systems Biology
2261:FEMS Microbiology Letters
2080:10.1042/0264-6021:3470469
1497:"Mouse PubMed Reference:"
1479:"Human PubMed Reference:"
1271:
1266:
1262:
1255:
1239:
1220:
1201:
1176:
1165:
1146:
1121:
1110:
1097:
1093:
1078:
1074:
1065:
1052:
1048:
1033:
1029:
1020:
1007:
1003:
988:
984:
975:
960:
953:
949:
933:
613:identical protein binding
588:
584:
567:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
1924:10.1002/elps.11501301199
1233:Chr 7: 126.3 – 126.31 Mb
1226:Chr 16: 30.18 – 30.19 Mb
885:regulation of cell shape
2230:10.1091/mbc.E05-01-0042
2175:The Biochemical Journal
2068:The Biochemical Journal
2004:10.1242/jcs.110.24.3071
1992:Journal of Cell Science
1783:10.1073/pnas.0700321104
1529:10.1089/dna.1998.17.779
1384:(also known as TgCor).
865:cell-substrate adhesion
1416:
1404:
1364:
1356:
1348:
925:phagolysosome assembly
890:innate immune response
643:actin filament binding
493:mesenteric lymph nodes
2375:Journal of Immunology
2309:10.1038/sj.cr.7310014
1414:
1402:
1362:
1354:
1346:
785:calcium ion transport
749:immunological synapse
669:extracellular exosome
628:actin monomer binding
198:Chromosome 16 (human)
1893:(Coronin-1A) at the
1866:genome location and
1517:DNA and Cell Biology
920:leukocyte chemotaxis
805:response to cytokine
339:7 69.25 cM|7 F3
300:Chromosome 7 (mouse)
67:List of PDB id codes
40:Available structures
1874:UCSC Genome Browser
1774:2007PNAS..104.7062S
910:uropod organization
830:positive chemotaxis
744:cytoplasmic vesicle
2344:10.1038/msb4100134
2187:10.1042/BJ20041020
2124:10.1248/bpb.26.409
1417:
1405:
1365:
1357:
1349:
1311:desired proteins.
1055:ENSMUSG00000030707
815:T cell homeostasis
773:Biological process
759:phagocytic vesicle
719:cell-cell junction
679:actin cytoskeleton
657:Cellular component
596:Molecular function
505:tibiofemoral joint
162:CORO1A - orthologs
2478:
2477:
1836:978-0-387-09594-3
1723:978-0-387-09594-3
1639:978-0-387-09594-3
1382:Toxoplasma gondii
1282:
1281:
1278:
1277:
1251:
1250:
1216:
1215:
1191:
1190:
1161:
1160:
1136:
1135:
1106:
1105:
1087:
1086:
1061:
1060:
1042:
1041:
1016:
1015:
997:
996:
945:
944:
694:cell leading edge
580:
579:
576:
575:
545:
544:
532:
531:
525:prefrontal cortex
470:
469:
451:bone marrow cells
368:
367:
267:
266:
94:
93:
90:
89:
50:Ortholog search:
2498:
2464:
2449:
2429:
2422:
2415:
2406:
2400:
2390:
2365:
2355:
2321:
2311:
2286:
2276:
2251:
2241:
2208:
2198:
2181:(Pt 2): 325–31.
2165:
2136:
2126:
2101:
2091:
2074:(Pt 2): 469–73.
2058:
2040:
2015:
1986:
1968:
1943:
1849:
1848:
1812:
1806:
1805:
1795:
1785:
1753:
1744:
1743:
1699:
1693:
1692:
1658:
1652:
1651:
1615:
1604:
1603:
1593:
1561:
1555:
1554:
1547:
1541:
1540:
1511:
1505:
1504:
1493:
1487:
1486:
1475:
1469:
1459:
1448:
1438:
1264:
1263:
1235:
1228:
1211:
1195:
1186:
1170:
1166:RefSeq (protein)
1156:
1140:
1131:
1115:
1091:
1072:
1046:
1027:
1001:
982:
951:
586:
572:
563:
556:
541:
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
2506:
2505:
2501:
2500:
2499:
2497:
2496:
2495:
2481:
2480:
2479:
2474:
2471:
2465:
2456:
2450:
2436:
2433:
2403:
2368:
2324:
2289:
2254:
2211:
2168:
2139:
2104:
2061:
2018:
1998:(24): 3071–81.
1989:
1946:
1912:Electrophoresis
1908:
1904:
1902:Further reading
1857:
1852:
1837:
1814:
1813:
1809:
1755:
1754:
1747:
1724:
1701:
1700:
1696:
1681:
1660:
1659:
1655:
1640:
1617:
1616:
1607:
1563:
1562:
1558:
1549:
1548:
1544:
1513:
1512:
1508:
1495:
1494:
1490:
1477:
1476:
1472:
1460:
1451:
1439:
1430:
1426:
1394:
1341:
1329:
1308:
1273:View/Edit Mouse
1268:View/Edit Human
1231:
1224:
1221:Location (UCSC)
1207:
1203:
1182:
1178:
1152:
1148:
1127:
1123:
1036:ENSG00000102879
929:
768:
739:plasma membrane
652:
603:protein binding
568:
537:
528:
523:
519:
517:right lung lobe
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
459:trabecular bone
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
2504:
2502:
2494:
2493:
2483:
2482:
2476:
2475:
2473:
2472:
2466:
2459:
2457:
2451:
2444:
2441:
2438:
2437:
2434:
2432:
2431:
2424:
2417:
2409:
2402:
2401:
2381:(9): 5769–78.
2366:
2322:
2287:
2252:
2224:(6): 2786–98.
2209:
2166:
2137:
2102:
2059:
2016:
1987:
1944:
1905:
1903:
1900:
1899:
1898:
1877:
1856:
1855:External links
1853:
1851:
1850:
1835:
1807:
1768:(17): 7062–7.
1745:
1722:
1694:
1680:978-0387095943
1679:
1653:
1638:
1605:
1556:
1542:
1506:
1488:
1470:
1449:
1427:
1425:
1422:
1393:
1390:
1340:
1337:
1328:
1325:
1307:
1304:
1280:
1279:
1276:
1275:
1270:
1260:
1259:
1253:
1252:
1249:
1248:
1246:
1244:
1237:
1236:
1229:
1222:
1218:
1217:
1214:
1213:
1199:
1198:
1192:
1189:
1188:
1174:
1173:
1167:
1163:
1162:
1159:
1158:
1144:
1143:
1137:
1134:
1133:
1119:
1118:
1112:
1108:
1107:
1104:
1103:
1095:
1094:
1088:
1085:
1084:
1076:
1075:
1069:
1063:
1062:
1059:
1058:
1050:
1049:
1043:
1040:
1039:
1031:
1030:
1024:
1018:
1017:
1014:
1013:
1005:
1004:
998:
995:
994:
986:
985:
979:
973:
972:
967:
962:
958:
957:
947:
946:
943:
942:
931:
930:
928:
927:
922:
917:
912:
907:
902:
900:cell migration
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
776:
774:
770:
769:
767:
766:
761:
756:
751:
746:
741:
736:
731:
729:actin filament
726:
721:
716:
714:early endosome
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
664:phagocytic cup
660:
658:
654:
653:
651:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
599:
597:
593:
592:
582:
581:
578:
577:
574:
573:
565:
564:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2503:
2492:
2489:
2488:
2486:
2469:
2463:
2458:
2454:
2448:
2443:
2439:
2430:
2425:
2423:
2418:
2416:
2411:
2410:
2407:
2398:
2394:
2389:
2384:
2380:
2376:
2372:
2367:
2363:
2359:
2354:
2349:
2345:
2341:
2337:
2333:
2329:
2323:
2319:
2315:
2310:
2305:
2302:(1): 106–12.
2301:
2297:
2296:Cell Research
2293:
2288:
2284:
2280:
2275:
2270:
2267:(1): 137–44.
2266:
2262:
2258:
2253:
2249:
2245:
2240:
2235:
2231:
2227:
2223:
2219:
2215:
2210:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2176:
2172:
2167:
2163:
2159:
2155:
2151:
2148:(1): 205–10.
2147:
2143:
2138:
2134:
2130:
2125:
2120:
2117:(4): 409–16.
2116:
2112:
2108:
2103:
2099:
2095:
2090:
2085:
2081:
2077:
2073:
2069:
2065:
2060:
2056:
2052:
2048:
2044:
2039:
2034:
2031:(4): 435–47.
2030:
2026:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1988:
1984:
1980:
1976:
1972:
1967:
1962:
1958:
1954:
1950:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1918:(12): 960–9.
1917:
1913:
1907:
1906:
1901:
1896:
1892:
1891:
1886:
1882:
1878:
1875:
1871:
1870:
1865:
1864:
1859:
1858:
1854:
1846:
1842:
1838:
1832:
1828:
1824:
1820:
1819:
1811:
1808:
1803:
1799:
1794:
1789:
1784:
1779:
1775:
1771:
1767:
1763:
1759:
1752:
1750:
1746:
1741:
1737:
1733:
1729:
1725:
1719:
1715:
1711:
1707:
1706:
1698:
1695:
1690:
1686:
1682:
1676:
1672:
1668:
1664:
1657:
1654:
1649:
1645:
1641:
1635:
1631:
1627:
1623:
1622:
1614:
1612:
1610:
1606:
1601:
1597:
1592:
1587:
1583:
1579:
1576:(3): 239–50.
1575:
1571:
1567:
1560:
1557:
1552:
1546:
1543:
1538:
1534:
1530:
1526:
1523:(9): 779–87.
1522:
1518:
1510:
1507:
1502:
1498:
1492:
1489:
1484:
1480:
1474:
1471:
1467:
1463:
1458:
1456:
1454:
1450:
1446:
1442:
1437:
1435:
1433:
1429:
1423:
1421:
1413:
1409:
1401:
1397:
1391:
1389:
1385:
1383:
1377:
1375:
1371:
1361:
1353:
1345:
1338:
1336:
1332:
1326:
1324:
1320:
1316:
1312:
1305:
1303:
1301:
1297:
1294:
1290:
1286:
1274:
1269:
1265:
1261:
1258:
1254:
1247:
1245:
1242:
1238:
1234:
1230:
1227:
1223:
1219:
1212:
1210:
1206:
1200:
1196:
1193:
1187:
1185:
1181:
1175:
1171:
1168:
1164:
1157:
1155:
1151:
1145:
1141:
1138:
1132:
1130:
1126:
1120:
1116:
1113:
1111:RefSeq (mRNA)
1109:
1102:
1101:
1096:
1092:
1089:
1083:
1082:
1077:
1073:
1070:
1068:
1064:
1057:
1056:
1051:
1047:
1044:
1038:
1037:
1032:
1028:
1025:
1023:
1019:
1012:
1011:
1006:
1002:
999:
993:
992:
987:
983:
980:
978:
974:
971:
968:
966:
963:
959:
956:
952:
948:
941:
937:
932:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
777:
775:
772:
771:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
704:lamellipodium
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
661:
659:
656:
655:
649:
648:actin binding
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
591:
590:Gene ontology
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2467:
2452:
2378:
2374:
2335:
2331:
2299:
2295:
2264:
2260:
2221:
2217:
2178:
2174:
2145:
2141:
2114:
2110:
2071:
2067:
2028:
2024:
1995:
1991:
1959:(3): 283–8.
1956:
1953:FEBS Letters
1952:
1915:
1911:
1888:
1868:
1862:
1817:
1810:
1765:
1761:
1704:
1697:
1662:
1656:
1620:
1573:
1569:
1559:
1545:
1520:
1516:
1509:
1500:
1491:
1482:
1473:
1418:
1406:
1395:
1386:
1381:
1378:
1366:
1333:
1330:
1321:
1317:
1313:
1309:
1292:
1284:
1283:
1205:NP_001288303
1202:
1180:NP_001180262
1177:
1150:NM_001301374
1147:
1125:NM_001193333
1122:
1098:
1079:
1053:
1034:
1008:
989:
969:
964:
800:phagocytosis
754:cytoskeleton
401:
394:
360:126,306,959
347:126,298,945
121:External IDs
72:
2435:PDB gallery
1374:calcineurin
1370:calcineurin
684:cell cortex
513:bone marrow
489:granulocyte
447:bone marrow
427:granulocyte
259:30,189,076
246:30,182,827
99:Identifiers
1570:Aging Cell
1468:, May 2017
1447:, May 2017
1424:References
1285:Coronin-1A
455:lymph node
405:(ortholog)
142:HomoloGene
2338:(1): 89.
1392:Structure
1327:Phylogeny
1306:Discovery
1300:apoptosis
1209:NP_034028
1184:NP_009005
1154:NM_009898
1129:NM_007074
955:Orthologs
674:cytoplasm
150:GeneCards
2485:Category
2397:17442961
2362:17353931
2318:16467882
2283:16040207
2248:15800061
2205:15601263
2162:15203218
2142:Genomics
2133:12673016
2098:10749676
2055:18159353
2047:10338208
1983:45276555
1940:41855774
1845:18925371
1802:17438295
1740:40384881
1732:18925376
1689:18925366
1648:18925369
1600:19245677
1464:–
1443:–
1339:Function
1257:Wikidata
934:Sources:
724:membrane
443:appendix
431:monocyte
2353:1847948
2239:1142424
2196:1134960
2089:1220979
2012:9365277
1994:. 110.
1975:7758584
1932:1286667
1895:PDBe-KB
1885:UniProt
1793:1855353
1770:Bibcode
1591:2759984
1537:9778037
1466:Ensembl
1445:Ensembl
1289:protein
1067:UniProt
1022:Ensembl
961:Species
940:QuickGO
764:cytosol
689:nucleus
380:pattern
238:16p11.2
138:1345961
106:Aliases
2395:
2360:
2350:
2316:
2281:
2246:
2236:
2203:
2193:
2160:
2131:
2096:
2086:
2053:
2045:
2010:
1981:
1973:
1938:
1930:
1890:O89053
1869:CORO1A
1863:CORO1A
1860:Human
1843:
1833:
1800:
1790:
1738:
1730:
1720:
1687:
1677:
1646:
1636:
1598:
1588:
1535:
1293:CORO1A
1243:search
1241:PubMed
1100:O89053
1081:P31146
977:Entrez
551:BioGPS
501:spleen
497:thymus
463:thymus
439:spleen
154:CORO1A
130:605000
113:CORO1A
22:CORO1A
2051:S2CID
1979:S2CID
1936:S2CID
1736:S2CID
1287:is a
1010:12721
991:11151
970:Mouse
965:Human
936:Amigo
509:blood
435:blood
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
2468:2b4e
2453:2aq5
2393:PMID
2358:PMID
2314:PMID
2279:PMID
2244:PMID
2201:PMID
2158:PMID
2129:PMID
2094:PMID
2043:PMID
2025:Cell
2008:PMID
1971:PMID
1928:PMID
1883:for
1841:PMID
1831:ISBN
1798:PMID
1728:PMID
1718:ISBN
1685:PMID
1675:ISBN
1644:PMID
1634:ISBN
1596:PMID
1533:PMID
1296:gene
699:axon
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
146:6545
126:OMIM
83:2B4E
79:2AQ5
75:2AKF
56:RCSB
53:PDBe
2383:doi
2379:178
2348:PMC
2340:doi
2304:doi
2269:doi
2265:250
2234:PMC
2226:doi
2191:PMC
2183:doi
2179:387
2150:doi
2119:doi
2084:PMC
2076:doi
2072:347
2033:doi
2000:doi
1996:110
1961:doi
1957:364
1920:doi
1881:PDB
1823:doi
1788:PMC
1778:doi
1766:104
1710:doi
1667:doi
1626:doi
1586:PMC
1578:doi
1525:doi
356:End
255:End
158:OMA
134:MGI
46:PDB
2487::
2391:.
2377:.
2373:.
2356:.
2346:.
2334:.
2330:.
2312:.
2300:16
2298:.
2294:.
2277:.
2263:.
2259:.
2242:.
2232:.
2222:16
2220:.
2216:.
2199:.
2189:.
2177:.
2173:.
2156:.
2146:84
2144:.
2127:.
2115:26
2113:.
2109:.
2092:.
2082:.
2070:.
2066:.
2049:.
2041:.
2029:97
2027:.
2023:.
2006:.
1977:.
1969:.
1955:.
1951:.
1934:.
1926:.
1916:13
1914:.
1887::
1839:.
1829:.
1796:.
1786:.
1776:.
1764:.
1760:.
1748:^
1734:.
1726:.
1716:.
1683:.
1673:.
1642:.
1632:.
1608:^
1594:.
1584:.
1572:.
1568:.
1531:.
1521:17
1519:.
1499:.
1481:.
1452:^
1431:^
938:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
2428:e
2421:t
2414:v
2399:.
2385::
2364:.
2342::
2336:3
2320:.
2306::
2285:.
2271::
2250:.
2228::
2207:.
2185::
2164:.
2152::
2135:.
2121::
2100:.
2078::
2057:.
2035::
2014:.
2002::
1985:.
1963::
1942:.
1922::
1897:.
1876:.
1847:.
1825::
1804:.
1780::
1772::
1742:.
1712::
1691:.
1669::
1650:.
1628::
1602:.
1580::
1574:8
1553:.
1539:.
1527::
1503:.
1485:.
280:)
177:)
160::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
