CREB-binding protein - Knowledge (XXG)

2263:(RTS) is a rare genetic disorder that is the result of genetic mutations in either CBP or p300. RTS Type 1, which is caused by CBP mutations, for which over 500 different variations have been documented, accounts for approximately 55% of all cases, whereas RTS Type 2, which is caused by any of the nearly 120 different types of p300 mutations, accounts for only 8% of diagnosed cases. The majority of these mutations have been shown to cause loss of function of the gene via deletions, point or truncating mutations. Statistics indicate that RTS patients have and increased risk of cancer, with approximately 5% of that attributable to pediatric malignancies originating from the neural crest. Individuals with RTS frequently have skeletal abnormalities, neuroanatomical defects, and mental impairments including lower levels of intelligence, attention deficits and impaired motor coordination. 2103:. Transgenically altered mice homozygous for mutated copies of CBP (missing the KAT domain), were also embryonic lethal, however instead, these mice had poor vascular angiogenesis and abnormal hematopoiesis characterized by the absence of progenitor cell proliferation and an altered hematopoietic microenvironment. The fact that both CBP and p300 homozygous knockouts were embryonic lethal suggest that these factors play a critical role in embryogenesis. The differential phenotypes of these embryos also indicate that CBP and p300 regulate different aspects of embryological development. 5958: 503: 480: 2471: 377: 402: 6123: 1653: 5943: 6018: 6048: 2087: 6093: 754: 5988: 5898: 2070:. CBP has two critical mechanisms by which it is able to regulate gene expression: as an acetyltransferase, and as a protein scaffold that helps recruit and construct the complexes that are necessary for transcription or chromatin remodeling. Phosphorylation of CBP increases its acetyltransferase activity, a process hypothesized to be regulated in a cell cycle dependent manner. Recent results suggest that novel CBP-mediated post-translational N- 761: 6003: 2167:, specifically lysine residues in the histones, weakens the electric charge interaction between the histone and DNA, causing this area to become more open and accessible for the machinery required for DNA replication. Two histone acetylation markers that have been associated with active regions include histone 3 lysine 18 acetylation (H3K18ac) and histone 3 lysine 27 acetylation (H3K27ac). It has also been shown that CBP acetylates two 5928: 5973: 46: 509: 408: 5913: 6108: 6033: 6063: 6078: 2112: 2127:. Given the concentrations of CDK2 present in the cell at this stage of the cell cycle, it was hypothesized that CDK2 may be a key regulator of these post-translational modifications. It turned out that administration of cyclin E/CDK2 inhibitors did in fact inhibit the enzymatic activity of CBP's KAT domain. Other proteins that have been shown to phosphorylate CBP include 2616:. For mice with homozygous point mutations in their CBP KIX domain, they demonstrated impaired motor skill learning and execution. In conjunction with the neurological challenges experienced by RTS patients (lower levels of intelligence, attention deficits), CBP is attributable to a variety of neurological symptoms characteristic of many different types of diseases. 2099:, the pathological protein (vIRF), was shown to be upregulated by CBP and repressed by p300. p300 homozygous knockout studies in mice were embryonic lethal, with improper neurulation and poor heart development occurring during their limited survival. Additionally, the fibroblasts isolated from these mice were unable to properly proliferate and were lacking the 2572:). Both are transcription factors critical for lipogenesis, and both are acetylated by CBP, a post translational modification that increases their transcriptional activity. To balance the increase in lipid synthesis, the body needs to be able to export the macromolecule out of cells and storage. Microsomal triglyceride transfer protein ( 2482:. Further analysis has also revealed that during the early stages of respiratory epithelium tumorigenesis, there is increased expression in CBP as well as AP-1 and cyclin D1, factors known to be associated with CBP transcriptional activity. This over-expression may lead to downstream signaling events that favor lung tumor development. 2627:(FASD) is a classification of diseases that all result from alcohol exposure during pregnancy. Symptoms of these disorders include poor cerebellar-dependent learning, motor coordination and impaired balance. In rats with FASD, it was shown that they had decreased concentrations of CBP and lower amounts of H3 and H4 acetylation. 1571: 1640:

Bromodomains (BRD) consist of approximately 110 amino acids, that function to recognize acetylated lysine molecules. They consist of four left-handed alpha helices connected by loops which form hydrophobic binding pockets. The bromodomain of CBP binds to regions of the genome are rich with acetylated

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helices that have high affinity for amphipathic protein sequences. Interestingly, these helices can fold into a number of different conformers which enables the domain to maintain both a level of promiscuity while also exerting regulatory control. The KIX domain controls the rate of transcription and

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Often in scientific papers (especially in less recent ones), CBP and p300 are used interchangeably as CBP/p300. This is a reasonable amalgamation given the sequence homology, structural similarity and binding behaviors of these two proteins. However, ongoing research shows that CBP and p300 maintain

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The nuclear receptor coactivator binding domain (NCBD) located at the c-terminus of CBP, in its unbound state, fluctuates between multiple conformations. Binding of a target protein to NCBD will cause it to fold into three helices specifically functioned to associated with the disordered domains of

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rich domains identified within CBP, only domains 1 and 3 (CH1, CH3) have had their structural functions resolved. A number of factors that associate with CBP bind to either the CH1 or CH3 domain, or to both, despite their locations at opposing ends of the protein. To date, little is known about the

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CBP has two transitional adapter zinc finger (TAZ) domains that each consist of four alpha helices stabilized by zinc ions. Both TAZ1 and TAZ2 domains favor the hydrophobic residues within amphipathic amino acid sequences, and their binding affinity is enhanced by the interaction of acidic residues

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gene causing synthesis of a mutated huntingtin (Htt) protein. Symptoms most frequently associated with this disease are movement disorders, including impaired motor function, behavioral modification and cognitive impairment that ultimately results in dementia. It has been observed in animal models

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The functional CBP is approximately 7362 nucleotides long and encodes 2,441 amino acids. CBP does not directly interact with promoter elements; it is brought to the site via protein-protein interactions that are the result of its different structural domains complexing with other transcriptional

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CREB has been shown to have neuroprotective properties. Because of its association with CBP, understanding the role of CBP in neurological pathways and how aberrations influence disease is becoming of increasing interest. Numerous animal models have been designed in order to evaluate changes in

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of CH1 and CH3 has been shown to break down into consensus sequences that are capable of chelating zinc ions (Zn). Experiments performed also showed that the residues in these sequences are obligatory for transcriptional coactivation to occur by either CH1 or CH3. The CH2 region, located in the

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cases, respectively. CBP is known to interact with the AR and ER in both coactivator and acetyltransferase contexts. Inhibition of CBP KAT activity has been shown to decrease AR and ER signaling by down regulating receptor expression; this in turn suppresses tumorigenesis of both malignancies.

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pathway. Association of CBP with β-catenin leads to the transcription of genes responsible for more aggressive cancer traits including the presence of cancer stem cell populations, decreased immune cell infiltration and likelihood of metastasis. Experiments studying the use of a small molecule

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Alzheimer's disease (AD) is a progressive neurodegenerative disease whose pathology is diagnosed based on the presence of neuritic amyloid beta (Aβ) plaques and neurofibrillary tau (τ) tangles. Because the exact causes of the disease are not clearly understood, there are a number of different

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mechanisms by which CBP is hypothesized to play a role in the progression of AD. In many cases of early-onset familial AD (FAD), there are mutations of the proteins that make up the enzyme responsible for the creation of Aβ plaques. CBP activity is decreased in the absence of these proteins (

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family of transcription factors are critical for taking a cell from G1 to S phase of the cell cycle. They bind to a sequence consensus in the promoter region of genes involved in DNA replication. CBP (and p300) have been shown to interact with E2F proteins as both a coactivator, and as an

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between CBP and other acetyltransferase called the monocytes leukemia zinc finger (MOZ), and or between MORF (MOZ-related factor) and MLL (mixed-lineage leukemia) genes. Both instances result in fused proteins in which C-terminus of CBP is lost, and the acetyltransferase domains from

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that HD subjects had diminished CBP activity and decreased neuronal histone acetylation. Research has shown that mutHtt directly interacts with CBP It has been hypothesized that mutant Htt is either capable of degrading CBP, or it directly inhibits CBP's acetyltransferase domain.

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that was published in 2000, which used a microinjection of an antibody against CBP/p300 significantly diminished the number of cells able to progress into S phase, further supporting the idea that CBP is essential in the transcription of factors necessary G1/S phase transition.

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Given the control CBP has over a wide variety of physiological processes, the development of inhibitors for CBP activity have become increasingly important as potential therapies. To date, only a fraction of what has been discovered have progressed into clinical trials.

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and are known to associate with more than 16,000 genes in humans; however, while these proteins share many structural features, emerging evidence suggests that these two co-activators may promote transcription of genes with different biological functions.

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The kinase-inducible domain (KID) interacting domain (KIX) also is the protein domain on CBP and p300 where heterodimers form from the interaction of CBP (or p300) with other transcription factors and coactivators. It consists of three alpha and two

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Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, et al. (November 2017). "GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)".

2412:), the most common genetic mutations in CBP are missense mutations (accounting for ~71% of all CBP mutations). The most frequent mutations occur in the KAT domain, resulting largely in either decreased or inhibited acetyltransferase activity. 2094:

It has been reported that despite having common histone substrates, when there are lower amounts of histone or acetyl-CoA available, CBP and p300 have different, preferred acetyltransferase substrates. In an experiment performed involving the

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has been shown to be critical for hematopoietic differentiation. Some of the proteins that bind to this domain have been shown to bind competitively—such as CREB and Myb—whereas others bind via allosteric cooperation as in the case of

1692:. The ability of CBP to acetylate p53 via its KAT domain, which then increases p53's affinity for CBP's bromodomain showcases an interesting mechanism by which this unique protein can self-servingly regulate gene transcription. 1515:. CBP has also been shown to help modulate liver function via maintenance of energy homeostasis in response to changes in cell nutrition conditions by regulating the activity of transcription factors and genes responsible for 2215:

to completely suppress CBP and p300 showed significant increases in protein concentrations for those normally targeted by the APC/C, and caused a number of cells to become arrested in the mitotic phase of the cell cycle.

2424:, decreased bone marrow cellularity , and hematopoietic differentiation abnormalities." By age 1, these mice had an increased incidence of leukemia or hematologic neoplasia. Interestingly, tumor sequencing showed 4606:

Ait-Si-Ali S, Ramirez S, Barre FX, Dkhissi F, Magnaghi-Jaulin L, Girault JA, et al. (November 1998). "Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A".

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degradation. Two subunits of the APC/C have been shown to directly interact with CBP: AP5, which is located in the Platform subdomain, and AP7, located in the Arc Lamp subdomain. Experiments performed using

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of CBP. What's interesting is that it is able to acetylate not just histones but other proteins as well. Currently there are over 100 known substrates for CBP's KAT domain including proteins such as p53,

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motor, learning and memory function in mice with CBP mutations. Conditional knockout (cKO) mice that were hemizygous for CBP or had CBP point mutations exhibited memory defects—specifically related to

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functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to alter chromatin structure making genes more accessible for

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Akinsiku OE, Soremekun OS, Olotu FA, Soliman ME (2020). "Exploring the Role of Asp1116 in Selective Drug Targeting of CREBcAMP- Responsive Element-binding Protein Implicated in Prostate Cancer".

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Wang Y, Xie Q, Tan H, Liao M, Zhu S, Zheng LL, et al. (November 2021). "Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies".

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CBP has been shown to play a role in every stage of tumor development. Due to its critical role in regulation of cell proliferation, growth, migration and apoptosis, it is considered to be an

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Minghetti L, Visentin S, Patrizio M, Franchini L, Ajmone-Cat MA, Levi G (May 2004). "Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions".

5966:: KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES 3356:"Update and Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques" 5942: 4817:

Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, et al. (December 2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression".

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inhibitor of β-catenin/CBP association (ICG-001), that does not block p300/β-catenin association, saw decreased carcinogenesis and increased cellular differentiation and apoptosis.

6017: 5121:"The CREB-binding protein (CBP)/β-catenin inhibitor E7386, co-created by Eisai and PRISM BioLab, achieved the clinical POC (Proof of Concept) | News Release：2021 | Eisai Co., Ltd" 1641:

lysine residues, meaning they have lost their positive charge, decreasing histone affinity for DNA, which makes the region more open and accessible for transcription. Acetylated

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The 380 protein residue lysine acetyltransferase (KAT) domain is arguably one of the most important and identifying structural components of CBP. Its activity is regulated via

2564:(synthesis of glucose). Experiments performed in diet-induced obese mice saw increased lipogenesis driven by over expression of sterol regulatory element binding protein 1C ( 6092: 1940: 516: 415: 5987: 5897: 1524: 3713:

Rouaux C, Loeffler JP, Boutillier AL (September 2004). "Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders".

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with positive side chains. Factors that bind to TAZ2 are also potentially regulated via acetylation due to its proximity to the acetyltransferase domain (KAT).

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its binding partners. Among the proteins known to bind to this region include ACTR (p160)--a coactivator for the thyroid and retinoid receptors, its homolog

5377:"An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991)" 3802:

Amidfar M, de Oliveira J, Kucharska E, Budni J, Kim YK (September 2020). "The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease".

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Different transcription pathways activated in cancers by β-catenin association with CBP or its homolog p300. ICG-001 inhibition only effects CBP/β-catenin.

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middle of the protein, in its acetyltransferase domain, does not contain this consensus sequence, and has not been conclusively shown to bind zinc ions.

2096: 1184: 338: 1165: 5927: 6156: 2573: 2190:(APC/C). This complex consists of numerous subunits that are grouped into two subdomains, the "Arc Lamp" and the "Platform," and functions as an 5231:"Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP" 2669:). Additionally, in mouse models of AD, it has been shown that there is a decrease in neuronal histone acetylation, a critical function of CBP. 5972: 4415: 2172: 1838: 1748: 1511:

has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads to cell differentiation and/ or

6514: 5877: 4011:"Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300" 3403:

Guo P, Chen W, Li H, Li M, Li L (October 2018). "The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications".

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activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation,

502: 69: 6519: 6149: 5071:"CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers" 2576:) is responsible for lipoprotein assembly and secretion, and it associates with an RNA helicase, DDX3, which interacts with CBP causing 5824: 2392:, or tumor suppressor. Contrarily To date, increased CBP activity has been implicated in a variety of different malignancies including 1935: 479: 5912: 5505: 2600: 2549: 1390: 6107: 1397: 6032: 5804: 5683:

Gibellini D, Vitone F, Schiavone P, Re MC (April 2005). "HIV-1 tat protein and cell proliferation and survival: a brief review".

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He ZX, Wei BF, Zhang X, Gong YP, Ma LY, Zhao W (January 2021). "Current development of CBP/p300 inhibitors in the last decade".

2492:(HNSCC) disease severity have been linked to the association of CBP with β-catenin, a critical factor involved in the canonical 6467: 6462: 3076: 3055: 2624: 2244: 2119:

Studies performed in the late 1990s demonstrated that peak CBP acetyltransferase activity occurs at the transition between the

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Bannwarth S, Gatignol A (January 2005). "HIV-1 TAR RNA: the target of molecular interactions between the virus and its host".

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Huntington's disease (HD) is a fatal, progressing neurodegenerative disorder that is the result of a genetic mutation in the

1970: 1705: 401: 376: 5830: 3072: 2435:. One explanation proposed for these experimental results is that CBP plays a role in hematopoietic stem cell self-renewal. 2260: 2139:. Ser-133 has been shown to be an important residue that is phosphorylated by PKA to initiate CBP transcriptional activity. 4360:

Mullan PB, Quinn JE, Harkin DP (September 2006). "The role of BRCA1 in transcriptional regulation and cell cycle control".

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Goldman PS, Tran VK, Goodman RH (1997). "The multifunctional role of the co-activator CBP in transcriptional regulation".

3750:"cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia" 3655:"Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer" 3051: 2459: 2421: 2063: 318: 4519:

Cantor AB, Orkin SH (May 2002). "Transcriptional regulation of erythropoiesis: an affair involving multiple partners".

6216: 2577: 1492: 515: 414: 31: 6131:: Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association 4480:"The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules" 2236: 2232: 2187: 2115:

CBP and p300 control cell cycle progression at various points through many of their different regulatory functions.

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Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D (2005). "A review of HIV-1 Tat protein biological effects".

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Matt T (2002). "Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP)".

4763:"Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation" 6172: 5870: 5543:

Liou LY, Herrmann CH, Rice AP (September 2004). "HIV-1 infection and regulation of Tat function in macrophages".

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Dutta R, Tiu B, Sakamoto KM (September 2016). "CBP/p300 acetyltransferase activity in hematologic malignancies".

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CBP also has a role in regulation of glucose homeostasis during fasting conditions. Research has also shown that

2447: 2034: 2029: 2024: 1848: 1733: 1666: 1593: 5798: 2443: 2000: 1229: 326: 6442: 4229:"Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders" 2636: 2592: 2086: 2019: 1858: 1843: 1484: 1210: 6427: 6248: 6180: 2655: 2439: 2425: 2100: 1945: 1536: 1469: 6077: 5789: 3138:

Chan HM, La Thangue NB (July 2001). "p300/CBP proteins: HATs for transcriptional bridges and scaffolds".

2587:, a hormone released when the body has low blood sugar, activates cAMP response element binding protein ( 2596: 2493: 2160: 2124: 2014: 390: 5863: 4826: 4616: 2489: 2405: 2228: 2067: 1504: 2556:(lipid synthesis) in response to increased glucose and insulin concentrations, and fasting promotes 1652: 305: 5836: 5794: 2580:

acetylation, which in turn increases the rate of transcription of MTP in a positive feedback loop.

1950: 1350: 1324: 1299: 5951:: Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR 1487:. This relatively unique acetyltransferase activity is also seen in another transcription enzyme, 5807: 5770: 5597: 5523: 5443: 5406: 5334: 5046: 5000: 4850: 4640: 4544: 4385: 4342: 4172: 3827: 3482: 3428: 2525: 350: 2470: 1354: 1303: 753: 5762: 5727: 5692: 5671: 5626: 5589: 5560: 5511: 5501: 5476: 5435: 5398: 5363: 5326: 5291: 5260: 5211: 5162: 5102: 5038: 4992: 4952: 4901: 4842: 4794: 4740: 4691: 4632: 4585: 4536: 4501: 4443: 4435: 4377: 4334: 4258: 4164: 4098: 4042: 3948: 3876: 3819: 3781: 3730: 3686: 3626: 3548: 3474: 3466: 3420: 3385: 3285: 3231: 3155: 2505: 2501: 2485: 2180: 1828: 1656:

Crystal structure of the human CBP bromodomain in complex with acetylated lysine. PBD id: 3P1C

1540: 1500: 1480: 298: 62: 6026:: Solution structure of the CITED2 transactivation domain in complex with the p300 CH1 domain 5752: 5717: 5661: 5651: 5618: 5581: 5552: 5493: 5468: 5427: 5388: 5355: 5316: 5250: 5242: 5201: 5193: 5154: 5092: 5082: 5030: 4984: 4942: 4932: 4891: 4881: 4834: 4784: 4774: 4730: 4722: 4681: 4671: 4624: 4575: 4528: 4491: 4427: 4369: 4324: 4316: 4248: 4240: 4154: 4088: 4078: 4032: 4022: 3940: 3866: 3858: 3811: 3771: 3761: 3722: 3676: 3666: 3616: 3608: 3538: 3528: 3458: 3412: 3375: 3367: 3275: 3221: 3211: 3147: 2613: 2212: 2191: 2132: 1499:

For example, CBP alone has been implicated in a wide variety of pathophysiologies including

760: 595: 526: 470: 425: 346: 4431: 6056:: Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb 5535: 3845:

Steven A, Friedrich M, Jank P, Heimer N, Budczies J, Denkert C, Seliger B (October 2020).

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Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, et al. (July 2018).

2568:), which works in coordination with the carbohydrate responsive-element binding protein ( 4830: 4620: 4329: 4304: 3200:"p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis" 45: 5457:"Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1" 5255: 5230: 5229:

Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, et al. (December 2012).

5206: 5181: 5097: 5070: 4947: 4920: 4896: 4869: 4789: 4762: 4735: 4710: 4686: 4659: 4253: 4228: 4093: 4066: 4037: 4010: 3871: 3846: 3776: 3749: 3681: 3654: 3621: 3596: 3543: 3516: 3380: 3355: 3226: 3199: 2557: 2111: 1958: 1800: 1709: 1508: 6101:: Structural basis for cooperative transcription factor binding to the CBP coactivator 5666: 5639: 5034: 1099: 1094: 1089: 1084: 1079: 1074: 1069: 1064: 1059: 1054: 1049: 1044: 1039: 1034: 1029: 1024: 1019: 1014: 1009: 1004: 999: 994: 989: 984: 979: 974: 969: 964: 959: 954: 949: 933: 928: 923: 918: 913: 897: 892: 887: 882: 877: 872: 867: 862: 857: 852: 842: 837: 832: 827: 822: 817: 812: 807: 802: 6508: 5849: 5359: 5050: 5004: 4416:"CREB-binding protein and p300: molecular integrators of hematopoietic transcription" 3831: 3486: 2513: 2393: 2148: 2071: 1532: 789: 5812: 5774: 5447: 5410: 5338: 4548: 4389: 4176: 3432: 2155:

CBP is also believed to facilitate the process of DNA replication during S phase by

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acetyltransferase, the latter of which causes increased E2F DNA binding affinity. A

330: 309:, AW558298, CBP, CBP/p300, KAT3A, p300/CBP, RSTS, CREB binding protein, RSTS1, MKHK1 5601: 5492:. Novartis Foundation Symposia. Vol. 259. pp. 208–17, discussion 218–25. 5488:

Greene WC, Chen LF (2004). "Regulation of NF-κB Action by Reversible Acetylation".

4854: 4644: 4346: 2992: 2168: 1995: 588: 367: 5996:: STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE 5906:: SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP 5246: 5120: 4143:"Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis" 1015:

regulation of transcription from RNA polymerase II promoter in response to hypoxia

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positive regulation of transforming growth factor beta receptor signaling pathway

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National Center for Biotechnology Information, U.S. National Library of Medicine

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National Center for Biotechnology Information, U.S. National Library of Medicine

2553: 2479: 2397: 2220: 1635: 1561: 1516: 5472: 5393: 5376: 5321: 5304: 4988: 4676: 3862: 3371: 2462:(ALL), it was reported approximately 18% of them had CBP KAT domain mutations. 1523:. CBP is also implicated in the etiologies of several other diseases including 671: 6258: 5375:

Combes R, Balls M, Bansil L, Barratt M, Bell D, Botham P, et al. (2002).

5305:"Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator" 4779: 4320: 4065:

Sapio L, Salzillo A, Ragone A, Illiano M, Spina A, Naviglio S (October 2020).

3815: 3726: 3671: 3517:"CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer" 3416: 2642: 2537: 2455:

proteins remain, resulting in up-regulated KAT activity and onset of disease.

2224: 2207: 1768: 1623: 1606: 487: 384: 334: 6141: 5622: 4439: 4067:"Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update" 3766: 3533: 3470: 6397: 5497: 5087: 4083: 4027: 3151: 2429: 2408:, and many others. According to the Catalog of Somatic Mutations in Cancer ( 1588: 1512: 1129: 847: 731: 609: 554: 541: 453: 440: 342: 5766: 5731: 5696: 5675: 5656: 5630: 5593: 5564: 5515: 5480: 5439: 5402: 5367: 5330: 5264: 5215: 5166: 5106: 5042: 4996: 4956: 4905: 4846: 4798: 4744: 4695: 4589: 4540: 4532: 4505: 4496: 4479: 4447: 4381: 4373: 4338: 4262: 4168: 4102: 4046: 3952: 3880: 3823: 3785: 3734: 3690: 3630: 3552: 3478: 3424: 3389: 3289: 3280: 3263: 3235: 3216: 3159: 2062:

This gene is ubiquitously expressed and is involved in the transcriptional

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Kim C, Yousefian-Jazi A, Choi SH, Chang I, Lee J, Ryu H (November 2021).

4580: 4563: 2584: 2389: 2195: 1905: 1584: 1528: 1421: 1274: 1255: 4838: 2591:), which then binds to CBP as a coactivator for transcription of FOXO1. 2186:

Another key component of the cell cycle that is regulated by CBP is the

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Amino acid sequence homology between CBP and p300 transcription factors.

1570: 868:

DNA-binding transcription repressor activity, RNA polymerase II-specific

6493: 6296: 6196: 5640:"The Vpr protein from HIV-1: distinct roles along the viral life cycle" 4921:"Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease" 4305:"CREBBP and p300 lysine acetyl transferases in the DNA damage response" 4159: 4142: 2541: 2529: 2199: 2164: 1241: 1196: 6011:: Non-native Solution Structure of a fragment of the CH1 domain of CBP 5706:"Decoding Tat: the biology of HIV Tat posttranslational modifications" 3597:"Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer" 275: 271: 267: 263: 259: 255: 251: 247: 243: 239: 235: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 183: 179: 175: 171: 167: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 115: 111: 107: 103: 99: 95: 91: 17: 6457: 6453: 6449: 6417: 5741:"The multiple functions of HIV-1 Tat: proliferation versus apoptosis" 5585: 2478:

CBP mutations, though relatively infrequent, have been identified in

2432: 2409: 2083:

distinct biological functions and should therefore not be conflated.

1778: 1405: 1151: 5456: 4141:

Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007).

6437: 6432: 6422: 6407: 6391: 6387: 6360: 6350: 6340: 6330: 6276: 6272: 6242: 6238: 6234: 6220: 6211: 6206: 6200: 6192: 4761:

Bodrug T, Welsh KA, Hinkle M, Emanuele MJ, Brown NG (2021-05-24).

4628: 2666: 2662: 2536:, is essential for organism survival. Diseases involving impaired 2533: 2176: 2136: 2085: 2047: 1990: 1985: 1980: 1920: 1895: 1873: 1868: 1853: 1763: 1758: 1753: 1681: 1651: 1646: 1619: 1569: 1488: 5757: 5740: 1114: 1110: 6402: 6263: 6252: 4478:

Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000).

2588: 2203: 1930: 1925: 1900: 1890: 1878: 1863: 1833: 1823: 1795: 1789: 1783: 1689: 1685: 1476: 1465: 322: 6145: 5859: 769: 5936:: NMR Structure of CBP Bromodomain in complex with p53 peptide 5855: 2143: 2042: 1915: 1910: 1818: 1677: 1642: 3748:

Wang H, Xu J, Lazarovici P, Quirion R, Zheng W (2018-08-30).

3264:"CREB-binding protein and p300 in transcriptional regulation" 2552:(NAFLD). In the context equilibrium, over nutrition promotes 1085:

positive regulation of transcription of Notch receptor target

5545:

The International Journal of Biochemistry & Cell Biology

4868:

Van Gils J, Magdinier F, Fergelot P, Lacombe D (June 2021).

4227:

Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31).

1479:

in humans, located on chromosome 16p13.3. CBP has intrinsic

4870:"Rubinstein-Taybi Syndrome: A Model of Epigenetic Disorder" 5790:

GeneReviews/NCBI/NIH/UW entry on Rubinstein-Taybi Syndrome

4564:"CBP-mediated post-translational N-glycosylation of BRCA2" 2194:

that targets components related to the cell cycle such as

5704:

Hetzer C, Dormeyer W, Schnölzer M, Ott M (October 2005).

4658:

Zhang H, Kong Q, Wang J, Jiang Y, Hua H (November 2020).

2904:

Colorectal cancer, head and neck squamous cell carcinoma

2723:

Solid tumors, neuroepithelial histone acetylation rescue

1065:

positive regulation of transcription by RNA polymerase II

990:

negative regulation of transcription by RNA polymerase II

5981:: NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex 1025:

transcription initiation from RNA polymerase II promoter

578: 5023:

Combinatorial Chemistry & High Throughput Screening

3354:

Akinsiku OE, Soremekun OS, Soliman ME (February 2021).

2864:

hematological malignancies, prostate and breast cancer

2707:

Hematological malignancies, androgen receptor positive

2446:, CBP has been shown to gain function. This occurs via 3847:"What turns CREB on? And off? And why does it matter?" 2804:

Solid tumors, prevents β-catenin/CBP protein-protein

2500:

Increased nuclear hormone signaling, mediated by the

2420:

Embryonic mice heterozygous for CBP (Cbp) exhibited "

1700:

Aka interferon response factor binding domain (IBiD)

743: 4660:"Complex roles of cAMP-PKA-CREB signaling in cancer" 985:

stimulatory C-type lectin receptor signaling pathway

6481: 6374: 6179: 4711:"Integrating Old and New Paradigms of G1/S Control" 4136: 4134: 4132: 1368: 1343: 1317: 1292: 1035:

positive regulation of type I interferon production

1000:

positive regulation of transcription, DNA-templated

838:

cis-regulatory region sequence-specific DNA binding

4601: 4599: 4130: 4128: 4126: 4124: 4122: 4120: 4118: 4116: 4114: 4112: 3068: 3066: 3064: 3047: 3045: 3043: 2239:. CBP and p300 play a role in the acetylation of 3510: 3508: 3506: 3504: 3502: 3500: 3498: 3496: 525: 424: 5016: 5014: 3349: 3347: 3345: 3343: 3341: 3339: 3337: 3335: 3333: 3331: 3329: 3327: 3325: 3323: 3321: 3319: 2985:Prevents CBP/HIF-1α protein-protein interaction 2595:is a transcription factor for enzymes including 2508:(ER) receptors, are responsible for a number of 1721:Proteins shown to interact specifically with CBP 5064: 5062: 5060: 4812: 4810: 4808: 3797: 3795: 3317: 3315: 3313: 3311: 3309: 3307: 3305: 3303: 3301: 3299: 2930:Acute myeloid leukemia (AML), prevents CBP/Myb 2749:Advanced castration resistant prostate cancer, 1468:is cAMP response element-binding protein) is a 4756: 4754: 4709:Rubin SM, Sage J, Skotheim JM (October 2020). 4473: 4471: 4469: 4467: 4465: 4463: 4461: 4459: 4457: 4409: 4407: 4405: 4403: 4401: 4399: 4298: 4296: 4294: 4292: 4222: 4220: 4218: 4216: 4214: 4212: 4210: 4208: 4206: 4004: 4002: 4000: 3998: 3996: 3994: 3992: 3990: 3988: 3986: 3984: 3982: 3926: 3924: 3922: 3920: 3918: 3916: 3914: 3912: 3910: 3648: 3646: 3644: 3642: 3640: 3590: 3588: 3586: 3584: 3582: 3073:GRCm38: Ensembl release 89: ENSMUSG00000022521 2862:Acute myeloid leukemia (AML), potential other 2846:Acute myeloid leukemia (AML), potential other 1649:have been shown to bind to CBP's bromodomain. 1609:, CREB binding domain, MYB interaction domain 1095:positive regulation of Notch signaling pathway 6157: 5921:: NMR Structure of IBiD, A Domain of CBP/p300 5871: 4303:Dutto I, Scalera C, Prosperi E (April 2018). 4290: 4288: 4286: 4284: 4282: 4280: 4278: 4276: 4274: 4272: 4204: 4202: 4200: 4198: 4196: 4194: 4192: 4190: 4188: 4186: 4060: 4058: 4056: 3980: 3978: 3976: 3974: 3972: 3970: 3968: 3966: 3964: 3962: 3908: 3906: 3904: 3902: 3900: 3898: 3896: 3894: 3892: 3890: 3580: 3578: 3576: 3574: 3572: 3570: 3568: 3566: 3564: 3562: 1507:. In these diseases, association of CBP with 8: 6489:Chromatin Structure Remodeling (RSC) Complex 6116:: STRUCTURAL DIVERSITY IN CBP P160 COMPLEXES 5303:Marcello A, Zoppé M, Giacca M (March 2001). 4970: 4968: 4966: 4562:Siddique H, Rao VN, Reddy ES (August 2009). 3708: 3706: 3704: 3702: 3700: 2603:), which are necessary for gluconeogenesis. 2003: 1574:Organization of the main CBP protein domains 4925:International Journal of Molecular Sciences 4767:Frontiers in Cell and Developmental Biology 3601:Cold Spring Harbor Perspectives in Medicine 3193: 3191: 3189: 3133: 3131: 3129: 3127: 3125: 3123: 3121: 3052:GRCh38: Ensembl release 89: ENSG00000005339 1696:Nuclear receptor coactivator binding domain 1592:interaction between these two domains. The 6164: 6150: 6142: 6041:: NMR structure of CBP TAZ1/CITED2 complex 5878: 5864: 5856: 5846:United States National Library of Medicine 5180:Farria A, Li W, Dent SY (September 2015). 3444: 3442: 3187: 3185: 3183: 3181: 3179: 3177: 3175: 3173: 3171: 3169: 2265: 1601:Kinase-inducible domain interacting domain 1543:, and many other neurological conditions. 1125: 1080:regulation of myeloid cell differentiation 1005:regulation of smoothened signaling pathway 960:regulation of transcription, DNA-templated 785: 566: 465: 362: 80: 5797:at the U.S. National Library of Medicine 5756: 5721: 5665: 5655: 5638:Le Rouzic E, Benichou S (February 2005). 5392: 5320: 5254: 5205: 5182:"KATs in cancer: functions and therapies" 5096: 5086: 5069:Waddell AR, Huang H, Liao D (June 2021). 4946: 4936: 4895: 4885: 4788: 4778: 4734: 4685: 4675: 4579: 4495: 4328: 4252: 4158: 4092: 4082: 4036: 4026: 3870: 3775: 3765: 3680: 3670: 3620: 3542: 3532: 3379: 3279: 3257: 3255: 3253: 3251: 3249: 3247: 3245: 3225: 3215: 893:DNA-binding transcription factor activity 5844:This article incorporates text from the 2680: 2469: 2110: 1556:Transitional adapter zinc finger domains 1491:(p300). Together, they are known as the 5893: 3451:European Journal of Medicinal Chemistry 3039: 2599:and phosphoenolpyruvate carboxykinase ( 1020:regulation of cellular response to heat 5531: 5521: 4664:Experimental Hematology & Oncology 4432:10.1182/blood.V95.3.745.003k05_745_755 3515:Bordonaro M, Lazarova DL (July 2015). 2458:For patients with a relapsing case of 2404:, colorectal cancer, acute leukemias, 980:N-terminal peptidyl-lysine acetylation 35: 3595:Attar N, Kurdistani SK (March 2017). 3026:Castration resistant prostate cancer 2765:Castration resistant prostate cancer 2267:Cancers with Frequent CBP Mutations 2097:Kaposi sarcoma-associated herpesvirus 1505:head and neck squamous cell carcinoma 1070:regulation of lipid metabolic process 530: 491: 486: 429: 388: 383: 7: 4309:Cellular and Molecular Life Sciences 3851:Cellular and Molecular Life Sciences 2682:Compounds identified to inhibit CBP 2438:In cases of patients diagnosed with 2188:anaphase promoting complex/cyclosome 888:peptide N-acetyltransferase activity 5284:Recent Progress in Hormone Research 4484:The Journal of Biological Chemistry 4015:The Journal of Biological Chemistry 3754:Frontiers in Molecular Neuroscience 3268:The Journal of Biological Chemistry 1100:protein-containing complex assembly 5455:Kino T, Pavlakis GN (April 2004). 5432:10.1023/B:NERE.0000021241.90133.89 5381:Alternatives to Laboratory Animals 4009:Dyson HJ, Wright PE (March 2016). 2223:key factors involved in different 2179:) that are involved in processing 1365: 1340: 1314: 1289: 1265: 1246: 1220: 1201: 1175: 1156: 898:transcription corepressor activity 858:histone acetyltransferase activity 843:transcription coregulator activity 808:transcription coactivator activity 748: 666: 604: 583: 27:Nuclear protein that binds to CREB 25: 5035:10.2174/1386207323666200219122057 4568:International Journal of Oncology 3933:Molecular Genetics and Metabolism 3521:World Journal of Gastroenterology 3405:Pathology & Oncology Research 1055:beta-catenin-TCF complex assembly 924:histone acetyltransferase complex 6482:ATP-dependent remodeling factors 6121: 6106: 6091: 6076: 6061: 6046: 6031: 6016: 6001: 5986: 5971: 5956: 5941: 5926: 5911: 5896: 5360:10.1046/j.1563-2571.2002.02010.x 2625:Fetal alcohol spectrum disorders 2620:Fetal alcohol spectrum disorders 2550:nonalcoholic fatty liver disease 2219:CBP and p300 have been shown to 759: 752: 514: 507: 501: 478: 413: 406: 400: 375: 44: 3262:Vo N, Goodman RH (April 2001). 3198:Yao W, Wang T, Huang F (2018). 2528:, which relies on a balance of 2245:post-translational modification 1661:Lysine acetyltransferase domain 1579:Cysteine-histidine rich regions 1060:regulation of apoptotic process 5574:Cell Biochemistry and Function 5490:Reversible Protein Acetylation 5147:Journal of Medicinal Chemistry 2316:Diffuse large B-cell lymphoma 2305:Marginal zone B-cell lymphoma 770:More reference expression data 732:More reference expression data 1: 5290:: 103–19, discussion 119–20. 5247:10.1158/1078-0432.CCR-12-0861 4233:Current Pharmaceutical Design 3204:BioMed Research International 2932:protein-protein interactions 2294:Skin squamous cell carcinoma 2107:Role in cell cycle regulation 975:embryonic digit morphogenesis 499: 398: 6515:Genes on human chromosome 16 5723:10.1016/j.micinf.2005.06.003 5557:10.1016/j.biocel.2004.02.018 5159:10.1021/acs.jmedchem.7b00796 4727:10.1016/j.molcel.2020.08.020 4245:10.2174/13816128113199990382 3463:10.1016/j.ejmech.2020.112861 2460:Acute Lymphoblastic Leukemia 2422:extramedullary hematopoiesis 995:transcription, DNA-templated 828:transcription factor binding 6071:: Structure CBP TAZ1 Domain 3945:10.1016/j.ymgme.2016.06.013 3613:10.1101/cshperspect.a026534 2848:hematological malignancies 2833:Breast and prostate cancer 2751:hematological malignancies 2693:Disease(s)/ areas targeted 2247:influences their function. 2243:response proteins and this 1493:p300-CBP coactivator family 32:p300-CBP coactivator family 6536: 6520:Transcription coregulators 6173:Transcription coregulators 5835:gene details page in the 5739:Peruzzi F (January 2006). 5473:10.1089/104454904773819789 5394:10.1177/026119290203000403 5322:10.1080/152165401753544241 4989:10.1016/j.phrs.2021.105702 4677:10.1186/s40164-020-00191-1 3863:10.1007/s00018-020-03525-8 3372:10.1007/s10930-020-09951-8 2653: 2634: 2448:chromosomal translocations 2416:Hematological malignancies 2360:Lung small-cell carcinoma 2237:non-homologous end joining 2233:nucleotide excision repair 1964: 1884: 1806: 1664: 1633: 1559: 878:acetyltransferase activity 848:signal transducer activity 29: 5891: 4780:10.3389/fcell.2021.687515 4321:10.1007/s00018-017-2717-4 3816:10.1016/j.lfs.2020.118020 3727:10.1016/j.bcp.2004.05.035 3672:10.1186/s13073-018-0569-7 3417:10.1007/s12253-018-0433-5 3108:"Mouse PubMed Reference:" 3090:"Human PubMed Reference:" 2327:Salivary gland carcinoma 2261:Rubinstein–Taybi syndrome 2256:Rubinstein–Taybi syndrome 1667:Histone acetyltransferase 1583:Although there are three 1436: 1431: 1427: 1420: 1404: 1385: 1372: 1347: 1336: 1321: 1296: 1285: 1272: 1268: 1253: 1249: 1240: 1227: 1223: 1208: 1204: 1195: 1182: 1178: 1163: 1159: 1150: 1135: 1128: 1124: 1108: 788: 784: 767: 751: 742: 729: 678: 669: 616: 607: 577: 569: 565: 548: 535: 498: 477: 468: 464: 447: 434: 397: 374: 365: 361: 316: 313: 303: 296: 291: 88: 83: 66: 61: 56: 52: 43: 38: 5799:Medical Subject Headings 5623:10.2174/1570162052772924 5235:Clinical Cancer Research 4977:Pharmacological Research 4414:Blobel GA (2000-02-01). 3767:10.3389/fnmol.2018.00255 3715:Biochemical Pharmacology 3534:10.3748/wjg.v21.i27.8238 2972:Gastrointestinal cancer 2444:Myelodysplastic Syndrome 1527:and other solid tumors, 1525:hematologic malignancies 883:acyltransferase activity 682:Rostral migratory stream 6443:Tripartite motif family 5745:Frontiers in Bioscience 5498:10.1002/0470862637.ch15 5088:10.3390/cancers13122872 4084:10.3390/cancers12113166 4028:10.1074/jbc.R115.692020 3152:10.1242/jcs.114.13.2363 3140:Journal of Cell Science 2649: 2630: 1075:protein destabilization 970:cellular response to UV 950:Notch signaling pathway 5710:Microbes and Infection 5685:The New Microbiologica 5657:10.1186/1742-4690-2-11 5420:Neurochemical Research 4533:10.1038/sj.onc.1205326 4497:10.1074/jbc.M910396199 4374:10.1038/sj.onc.1209872 3281:10.1074/jbc.R000025200 2778:Multiple myeloma (MM) 2607:Neurological disorders 2560:(lipid breakdown) and 2475: 2440:Acute Myeloid Leukemia 2426:loss of heterozygosity 2349:Endometrial carcinoma 2161:origins of replication 2116: 2101:retinoic acid receptor 2091: 1657: 1575: 1391:Chr 16: 3.73 – 3.88 Mb 5819:- The Interactive Fly 5795:CREBBP+protein,+human 5348:Acta Medica Austriaca 4938:10.3390/ijms222212499 4887:10.3390/genes12070968 2878:Renal cell carcinoma 2690:Stage of development 2597:glucose-6-phosphatase 2521:Metabolic homeostasis 2473: 2371:ER+ Breast carcinoma 2278:% of samples mutated 2227:processes, including 2125:cell cycle checkpoint 2114: 2089: 2078:Distinction from p300 2068:transcription factors 1655: 1573: 1398:Chr 16: 3.9 – 4.03 Mb 493:Chromosome 16 (mouse) 391:Chromosome 16 (human) 5829:genome location and 5611:Current HIV Research 5461:DNA and Cell Biology 5198:10.1038/onc.2014.453 4581:10.3892/ijo_00000351 3217:10.1155/2018/8168791 3146:(Pt 13): 2363–2373. 2946:Lung adenocarcinoma 2736:Autoimmune diseases 2637:Huntington's disease 2631:Huntington's disease 2490:head and neck cancer 2406:head and neck cancer 2283:Follicular lymphoma 2229:base excision repair 2157:acetylating histones 1450:CREB-binding protein 803:transferase activity 532:16 A1|16 2.4 cM 84:List of PDB id codes 57:Available structures 5837:UCSC Genome Browser 4839:10.1038/nature04151 4831:2005Natur.438..690T 4621:1998Natur.396..184A 4490:(20): 15128–15134. 3360:The Protein Journal 3274:(17): 13505–13508. 2830:In vitro/ in vivio 2683: 2656:Alzheimer's disease 2650:Alzheimer's disease 2268: 2192:E3 ubiquitin ligase 1537:Alzheimer's disease 1050:homeostatic process 1045:protein acetylation 1040:signal transduction 1010:histone acetylation 955:response to hypoxia 863:damaged DNA binding 632:germinal epithelium 6086:: IRF3-CBP complex 5848:, which is in the 4160:10.1038/cr.2007.10 3010:In vitro/ in vivo 2997:In vitro/ in vivo 2982:In vitro/ in vivo 2956:In vitro/ in vivo 2943:In vitro/ in vivo 2914:In vitro/ in vivo 2901:In vitro/ in vivo 2888:In vitro/ in vivo 2875:In vitro/ in vivo 2859:In vitro/ in vivo 2843:In vitro/ in vivo 2820:Esophageal cancer 2817:In vitro/ in vivo 2762:In vitro/ in vivo 2720:In vitro/ in vivo 2704:In vitro/ in vivo 2681: 2538:metabolic activity 2526:Energy homeostasis 2476: 2338:Bladder carcinoma 2266: 2117: 2092: 2066:of many different 1658: 1576: 1230:ENSMUSG00000022521 943:Biological process 907:Cellular component 796:Molecular function 355:CREBBP - orthologs 6502: 6501: 6139: 6138: 5716:(13): 1364–1369. 5241:(24): 6623–6633. 5192:(38): 4901–4913. 5153:(22): 9162–9183. 4825:(7068): 690–695. 4615:(6707): 184–186. 4527:(21): 3368–3376. 4368:(43): 5854–5863. 4239:(28): 5051–5064. 4021:(13): 6714–6722. 3857:(20): 4049–4067. 3527:(27): 8238–8248. 3032: 3031: 2673:Inhibition of CBP 2486:Colorectal cancer 2381: 2380: 2181:Okazaki fragments 2163:. Acetylation of 2055: 2054: 1616: 1594:primary structure 1501:colorectal cancer 1481:acetyltransferase 1447: 1446: 1443: 1442: 1416: 1415: 1381: 1380: 1362: 1361: 1332: 1331: 1311: 1310: 1281: 1280: 1262: 1261: 1236: 1235: 1217: 1216: 1191: 1190: 1172: 1171: 1120: 1119: 853:metal ion binding 833:chromatin binding 780: 779: 776: 775: 738: 737: 725: 724: 663: 662: 644:bone marrow cells 561: 560: 460: 459: 287: 286: 283: 282: 67:Ortholog search: 16:(Redirected from 6527: 6398:Hairless homolog 6325:AIB/SRC-3/TRAM-1 6315:GRIP1/SRC-2/TIF2 6255:Drip205/Trap220) 6166: 6159: 6152: 6143: 6125: 6110: 6095: 6080: 6065: 6050: 6035: 6020: 6005: 5990: 5975: 5960: 5945: 5930: 5915: 5900: 5880: 5873: 5866: 5857: 5778: 5760: 5735: 5725: 5700: 5679: 5669: 5659: 5634: 5605: 5586:10.1002/cbf.1147 5568: 5551:(9): 1767–1775. 5539: 5533: 5529: 5527: 5519: 5484: 5451: 5414: 5396: 5371: 5342: 5324: 5299: 5269: 5268: 5258: 5226: 5220: 5219: 5209: 5177: 5171: 5170: 5141: 5135: 5134: 5132: 5131: 5117: 5111: 5110: 5100: 5090: 5066: 5055: 5054: 5018: 5009: 5008: 4972: 4961: 4960: 4950: 4940: 4916: 4910: 4909: 4899: 4889: 4865: 4859: 4858: 4814: 4803: 4802: 4792: 4782: 4758: 4749: 4748: 4738: 4706: 4700: 4699: 4689: 4679: 4655: 4649: 4648: 4603: 4594: 4593: 4583: 4559: 4553: 4552: 4516: 4510: 4509: 4499: 4475: 4452: 4451: 4411: 4394: 4393: 4357: 4351: 4350: 4332: 4315:(8): 1325–1338. 4300: 4267: 4266: 4256: 4224: 4181: 4180: 4162: 4138: 4107: 4106: 4096: 4086: 4062: 4051: 4050: 4040: 4030: 4006: 3957: 3956: 3928: 3885: 3884: 3874: 3842: 3836: 3835: 3799: 3790: 3789: 3779: 3769: 3745: 3739: 3738: 3721:(6): 1157–1164. 3710: 3695: 3694: 3684: 3674: 3650: 3635: 3634: 3624: 3592: 3557: 3556: 3546: 3536: 3512: 3491: 3490: 3446: 3437: 3436: 3400: 3394: 3393: 3383: 3351: 3294: 3293: 3283: 3259: 3240: 3239: 3229: 3219: 3195: 3164: 3163: 3135: 3116: 3115: 3104: 3098: 3097: 3086: 3080: 3070: 3059: 3049: 2959:Prostate cancer 2891:CBP bromodomain 2709:prostate cancer 2684: 2614:long-term memory 2269: 2010: 2006: 1725: 1724: 1614: 1452:, also known as 1429: 1428: 1400: 1393: 1376: 1366: 1357: 1341: 1337:RefSeq (protein) 1327: 1315: 1306: 1290: 1266: 1247: 1221: 1202: 1176: 1157: 1126: 965:rhythmic process 818:zinc ion binding 786: 772: 763: 756: 749: 734: 706:secondary oocyte 698:Ileal epithelium 674: 672:Top expressed in 667: 652:caput epididymis 640:endothelial cell 612: 610:Top expressed in 605: 584: 567: 557: 544: 533: 518: 511: 505: 494: 482: 466: 456: 443: 432: 417: 410: 404: 393: 379: 363: 357: 308: 301: 278: 81: 75: 54: 53: 48: 36: 21: 6535: 6534: 6530: 6529: 6528: 6526: 6525: 6524: 6505: 6504: 6503: 6498: 6477: 6461: 6370: 6299: 6175: 6170: 6140: 6135: 6132: 6126: 6117: 6111: 6102: 6096: 6087: 6081: 6072: 6066: 6057: 6051: 6042: 6036: 6027: 6021: 6012: 6006: 5997: 5991: 5982: 5976: 5967: 5961: 5952: 5946: 5937: 5931: 5922: 5916: 5907: 5901: 5887: 5884: 5786: 5781: 5738: 5703: 5682: 5637: 5608: 5571: 5542: 5530: 5520: 5508: 5487: 5454: 5417: 5374: 5345: 5302: 5281: 5277: 5275:Further reading 5272: 5228: 5227: 5223: 5179: 5178: 5174: 5143: 5142: 5138: 5129: 5127: 5119: 5118: 5114: 5068: 5067: 5058: 5020: 5019: 5012: 4974: 4973: 4964: 4918: 4917: 4913: 4867: 4866: 4862: 4816: 4815: 4806: 4760: 4759: 4752: 4708: 4707: 4703: 4657: 4656: 4652: 4605: 4604: 4597: 4561: 4560: 4556: 4518: 4517: 4513: 4477: 4476: 4455: 4413: 4412: 4397: 4359: 4358: 4354: 4302: 4301: 4270: 4226: 4225: 4184: 4140: 4139: 4110: 4064: 4063: 4054: 4008: 4007: 3960: 3930: 3929: 3888: 3844: 3843: 3839: 3801: 3800: 3793: 3747: 3746: 3742: 3712: 3711: 3698: 3659:Genome Medicine 3652: 3651: 3638: 3594: 3593: 3560: 3514: 3513: 3494: 3448: 3447: 3440: 3402: 3401: 3397: 3353: 3352: 3297: 3261: 3260: 3243: 3197: 3196: 3167: 3137: 3136: 3119: 3106: 3105: 3101: 3088: 3087: 3083: 3071: 3062: 3050: 3041: 3037: 3000:Liver fibrosis 2675: 2658: 2652: 2639: 2633: 2622: 2609: 2562:gluconeogenesis 2546:Type 2 Diabetes 2523: 2468: 2418: 2402:prostate cancer 2386: 2258: 2253: 2251:Role in disease 2109: 2080: 2060: 2008: 2004: 1718: 1698: 1673:phosphorylation 1669: 1663: 1638: 1632: 1603: 1581: 1564: 1558: 1552:co-activators. 1549: 1521:gluconeogenesis 1472:encoded by the 1438:View/Edit Mouse 1433:View/Edit Human 1396: 1389: 1386:Location (UCSC) 1374: 1353: 1349: 1323: 1302: 1298: 1211:ENSG00000005339 1104: 938: 902: 873:protein binding 768: 758: 757: 730: 721: 716: 712: 708: 704: 700: 696: 692: 688: 686:ascending aorta 684: 670: 659: 654: 650: 646: 642: 638: 636:Achilles tendon 634: 630: 626: 622: 608: 552: 539: 531: 521: 520: 519: 512: 492: 469:Gene location ( 451: 438: 430: 420: 419: 418: 411: 389: 366:Gene location ( 317: 304: 297: 90: 68: 34: 28: 23: 22: 15: 12: 11: 5: 6533: 6531: 6523: 6522: 6517: 6507: 6506: 6500: 6499: 6497: 6496: 6491: 6485: 6483: 6479: 6478: 6476: 6475: 6465: 6440: 6435: 6430: 6425: 6420: 6415: 6405: 6400: 6395: 6380: 6378: 6372: 6371: 6369: 6368: 6358: 6348: 6338: 6328: 6318: 6308: 6294: 6280: 6266: 6261: 6256: 6246: 6228: 6214: 6209: 6204: 6185: 6183: 6177: 6176: 6171: 6169: 6168: 6161: 6154: 6146: 6137: 6136: 6134: 6133: 6127: 6120: 6118: 6112: 6105: 6103: 6097: 6090: 6088: 6082: 6075: 6073: 6067: 6060: 6058: 6052: 6045: 6043: 6037: 6030: 6028: 6022: 6015: 6013: 6007: 6000: 5998: 5992: 5985: 5983: 5977: 5970: 5968: 5962: 5955: 5953: 5947: 5940: 5938: 5932: 5925: 5923: 5917: 5910: 5908: 5902: 5895: 5892: 5889: 5888: 5885: 5883: 5882: 5875: 5868: 5860: 5841: 5840: 5821: 5810: 5802: 5792: 5785: 5784:External links 5782: 5780: 5779: 5736: 5701: 5680: 5635: 5606: 5580:(4): 223–227. 5569: 5540: 5532:|journal= 5506: 5485: 5467:(4): 193–205. 5452: 5426:(5): 965–978. 5415: 5387:(4): 365–406. 5372: 5343: 5315:(3): 175–181. 5300: 5278: 5276: 5273: 5271: 5270: 5221: 5172: 5136: 5112: 5056: 5029:(3): 178–184. 5010: 4962: 4911: 4860: 4804: 4750: 4721:(2): 183–192. 4715:Molecular Cell 4701: 4650: 4595: 4574:(2): 387–391. 4554: 4511: 4453: 4426:(3): 745–755. 4395: 4352: 4268: 4182: 4153:(4): 324–332. 4108: 4052: 3958: 3939:(1–2): 37–43. 3886: 3837: 3791: 3740: 3696: 3636: 3607:(3): a026534. 3558: 3492: 3438: 3411:(4): 807–813. 3395: 3295: 3241: 3165: 3117: 3099: 3081: 3060: 3038: 3036: 3033: 3030: 3029: 3027: 3024: 3021: 3017: 3016: 3014: 3013:Neuroblastoma 3011: 3008: 3004: 3003: 3001: 2998: 2995: 2989: 2988: 2986: 2983: 2980: 2976: 2975: 2973: 2970: 2967: 2963: 2962: 2960: 2957: 2954: 2950: 2949: 2947: 2944: 2941: 2937: 2936: 2934: 2928: 2925: 2921: 2920: 2918: 2915: 2912: 2908: 2907: 2905: 2902: 2899: 2895: 2894: 2892: 2889: 2886: 2882: 2881: 2879: 2876: 2873: 2869: 2868: 2866: 2860: 2857: 2853: 2852: 2850: 2844: 2841: 2837: 2836: 2834: 2831: 2828: 2824: 2823: 2821: 2818: 2815: 2811: 2810: 2808: 2802: 2799: 2795: 2794: 2792: 2789: 2786: 2782: 2781: 2779: 2776: 2773: 2769: 2768: 2766: 2763: 2760: 2756: 2755: 2753: 2747: 2744: 2740: 2739: 2737: 2734: 2731: 2727: 2726: 2724: 2721: 2718: 2714: 2713: 2711: 2705: 2702: 2698: 2697: 2694: 2691: 2688: 2674: 2671: 2654:Main article: 2651: 2648: 2635:Main article: 2632: 2629: 2621: 2618: 2608: 2605: 2522: 2519: 2467: 2464: 2417: 2414: 2385: 2382: 2379: 2378: 2375: 2372: 2368: 2367: 2364: 2361: 2357: 2356: 2353: 2350: 2346: 2345: 2342: 2339: 2335: 2334: 2331: 2328: 2324: 2323: 2320: 2317: 2313: 2312: 2309: 2306: 2302: 2301: 2298: 2295: 2291: 2290: 2287: 2284: 2280: 2279: 2276: 2273: 2257: 2254: 2252: 2249: 2149:knockout study 2108: 2105: 2079: 2076: 2059: 2056: 2053: 2052: 2051: 2050: 2045: 2040: 2037: 2032: 2027: 2022: 2017: 2012: 1998: 1993: 1988: 1983: 1978: 1973: 1966: 1963: 1962: 1961: 1956: 1953: 1948: 1943: 1938: 1933: 1928: 1923: 1918: 1913: 1908: 1903: 1898: 1893: 1886: 1883: 1882: 1881: 1876: 1871: 1866: 1861: 1856: 1851: 1846: 1841: 1836: 1831: 1826: 1821: 1816: 1813: 1808: 1805: 1804: 1803: 1798: 1793: 1787: 1781: 1776: 1771: 1766: 1761: 1756: 1751: 1746: 1741: 1736: 1731: 1717: 1714: 1697: 1694: 1665:Main article: 1662: 1659: 1634:Main article: 1631: 1628: 1602: 1599: 1580: 1577: 1560:Main article: 1557: 1554: 1548: 1545: 1445: 1444: 1441: 1440: 1435: 1425: 1424: 1418: 1417: 1414: 1413: 1411: 1409: 1402: 1401: 1394: 1387: 1383: 1382: 1379: 1378: 1370: 1369: 1363: 1360: 1359: 1345: 1344: 1338: 1334: 1333: 1330: 1329: 1319: 1318: 1312: 1309: 1308: 1294: 1293: 1287: 1283: 1282: 1279: 1278: 1270: 1269: 1263: 1260: 1259: 1251: 1250: 1244: 1238: 1237: 1234: 1233: 1225: 1224: 1218: 1215: 1214: 1206: 1205: 1199: 1193: 1192: 1189: 1188: 1180: 1179: 1173: 1170: 1169: 1161: 1160: 1154: 1148: 1147: 1142: 1137: 1133: 1132: 1122: 1121: 1118: 1117: 1106: 1105: 1103: 1102: 1097: 1092: 1087: 1082: 1077: 1072: 1067: 1062: 1057: 1052: 1047: 1042: 1037: 1032: 1027: 1022: 1017: 1012: 1007: 1002: 997: 992: 987: 982: 977: 972: 967: 962: 957: 952: 946: 944: 940: 939: 937: 936: 931: 926: 921: 916: 910: 908: 904: 903: 901: 900: 895: 890: 885: 880: 875: 870: 865: 860: 855: 850: 845: 840: 835: 830: 825: 820: 815: 810: 805: 799: 797: 793: 792: 782: 781: 778: 777: 774: 773: 765: 764: 746: 740: 739: 736: 735: 727: 726: 723: 722: 720: 719: 715: 714:primary oocyte 711: 707: 703: 699: 695: 691: 687: 683: 679: 676: 675: 664: 661: 660: 658: 657: 653: 649: 645: 641: 637: 633: 629: 628:amniotic fluid 625: 621: 617: 614: 613: 601: 600: 592: 581: 575: 574: 571:RNA expression 563: 562: 559: 558: 550: 546: 545: 537: 534: 529: 523: 522: 513: 506: 500: 496: 495: 490: 484: 483: 475: 474: 462: 461: 458: 457: 449: 445: 444: 436: 433: 428: 422: 421: 412: 405: 399: 395: 394: 387: 381: 380: 372: 371: 359: 358: 315: 311: 310: 302: 294: 293: 289: 288: 285: 284: 281: 280: 86: 85: 77: 76: 65: 59: 58: 50: 49: 41: 40: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 6532: 6521: 6518: 6516: 6513: 6512: 6510: 6495: 6492: 6490: 6487: 6486: 6484: 6480: 6473: 6469: 6466: 6464: 6459: 6455: 6451: 6447: 6444: 6441: 6439: 6436: 6434: 6431: 6429: 6426: 6424: 6421: 6419: 6416: 6413: 6409: 6406: 6404: 6401: 6399: 6396: 6393: 6389: 6385: 6382: 6381: 6379: 6377: 6373: 6366: 6362: 6359: 6356: 6352: 6349: 6346: 6342: 6339: 6336: 6332: 6329: 6326: 6322: 6319: 6316: 6312: 6309: 6306: 6302: 6298: 6295: 6292: 6288: 6284: 6281: 6278: 6274: 6270: 6267: 6265: 6262: 6260: 6257: 6254: 6250: 6247: 6244: 6240: 6236: 6232: 6229: 6226: 6222: 6218: 6215: 6213: 6210: 6208: 6205: 6202: 6198: 6194: 6190: 6187: 6186: 6184: 6182: 6178: 6174: 6167: 6162: 6160: 6155: 6153: 6148: 6147: 6144: 6130: 6124: 6119: 6115: 6109: 6104: 6100: 6094: 6089: 6085: 6079: 6074: 6070: 6064: 6059: 6055: 6049: 6044: 6040: 6034: 6029: 6025: 6019: 6014: 6010: 6004: 5999: 5995: 5989: 5984: 5980: 5974: 5969: 5965: 5959: 5954: 5950: 5944: 5939: 5935: 5929: 5924: 5920: 5914: 5909: 5905: 5899: 5894: 5890: 5881: 5876: 5874: 5869: 5867: 5862: 5861: 5858: 5854: 5853: 5851: 5850:public domain 5847: 5838: 5834: 5833: 5828: 5827: 5822: 5820: 5818: 5815: 5811: 5809: 5806: 5803: 5800: 5796: 5793: 5791: 5788: 5787: 5783: 5776: 5772: 5768: 5764: 5759: 5754: 5750: 5746: 5742: 5737: 5733: 5729: 5724: 5719: 5715: 5711: 5707: 5702: 5698: 5694: 5691:(2): 95–109. 5690: 5686: 5681: 5677: 5673: 5668: 5663: 5658: 5653: 5649: 5645: 5644:Retrovirology 5641: 5636: 5632: 5628: 5624: 5620: 5616: 5612: 5607: 5603: 5599: 5595: 5591: 5587: 5583: 5579: 5575: 5570: 5566: 5562: 5558: 5554: 5550: 5546: 5541: 5537: 5525: 5517: 5513: 5509: 5507:9780470862612 5503: 5499: 5495: 5491: 5486: 5482: 5478: 5474: 5470: 5466: 5462: 5458: 5453: 5449: 5445: 5441: 5437: 5433: 5429: 5425: 5421: 5416: 5412: 5408: 5404: 5400: 5395: 5390: 5386: 5382: 5378: 5373: 5369: 5365: 5361: 5357: 5353: 5349: 5344: 5340: 5336: 5332: 5328: 5323: 5318: 5314: 5310: 5306: 5301: 5297: 5293: 5289: 5285: 5280: 5279: 5274: 5266: 5262: 5257: 5252: 5248: 5244: 5240: 5236: 5232: 5225: 5222: 5217: 5213: 5208: 5203: 5199: 5195: 5191: 5187: 5183: 5176: 5173: 5168: 5164: 5160: 5156: 5152: 5148: 5140: 5137: 5126: 5125:www.eisai.com 5122: 5116: 5113: 5108: 5104: 5099: 5094: 5089: 5084: 5080: 5076: 5072: 5065: 5063: 5061: 5057: 5052: 5048: 5044: 5040: 5036: 5032: 5028: 5024: 5017: 5015: 5011: 5006: 5002: 4998: 4994: 4990: 4986: 4982: 4978: 4971: 4969: 4967: 4963: 4958: 4954: 4949: 4944: 4939: 4934: 4931:(22): 12499. 4930: 4926: 4922: 4915: 4912: 4907: 4903: 4898: 4893: 4888: 4883: 4879: 4875: 4871: 4864: 4861: 4856: 4852: 4848: 4844: 4840: 4836: 4832: 4828: 4824: 4820: 4813: 4811: 4809: 4805: 4800: 4796: 4791: 4786: 4781: 4776: 4772: 4768: 4764: 4757: 4755: 4751: 4746: 4742: 4737: 4732: 4728: 4724: 4720: 4716: 4712: 4705: 4702: 4697: 4693: 4688: 4683: 4678: 4673: 4669: 4665: 4661: 4654: 4651: 4646: 4642: 4638: 4634: 4630: 4629:10.1038/24190 4626: 4622: 4618: 4614: 4610: 4602: 4600: 4596: 4591: 4587: 4582: 4577: 4573: 4569: 4565: 4558: 4555: 4550: 4546: 4542: 4538: 4534: 4530: 4526: 4522: 4515: 4512: 4507: 4503: 4498: 4493: 4489: 4485: 4481: 4474: 4472: 4470: 4468: 4466: 4464: 4462: 4460: 4458: 4454: 4449: 4445: 4441: 4437: 4433: 4429: 4425: 4421: 4417: 4410: 4408: 4406: 4404: 4402: 4400: 4396: 4391: 4387: 4383: 4379: 4375: 4371: 4367: 4363: 4356: 4353: 4348: 4344: 4340: 4336: 4331: 4326: 4322: 4318: 4314: 4310: 4306: 4299: 4297: 4295: 4293: 4291: 4289: 4287: 4285: 4283: 4281: 4279: 4277: 4275: 4273: 4269: 4264: 4260: 4255: 4250: 4246: 4242: 4238: 4234: 4230: 4223: 4221: 4219: 4217: 4215: 4213: 4211: 4209: 4207: 4205: 4203: 4201: 4199: 4197: 4195: 4193: 4191: 4189: 4187: 4183: 4178: 4174: 4170: 4166: 4161: 4156: 4152: 4148: 4147:Cell Research 4144: 4137: 4135: 4133: 4131: 4129: 4127: 4125: 4123: 4121: 4119: 4117: 4115: 4113: 4109: 4104: 4100: 4095: 4090: 4085: 4080: 4076: 4072: 4068: 4061: 4059: 4057: 4053: 4048: 4044: 4039: 4034: 4029: 4024: 4020: 4016: 4012: 4005: 4003: 4001: 3999: 3997: 3995: 3993: 3991: 3989: 3987: 3985: 3983: 3981: 3979: 3977: 3975: 3973: 3971: 3969: 3967: 3965: 3963: 3959: 3954: 3950: 3946: 3942: 3938: 3934: 3927: 3925: 3923: 3921: 3919: 3917: 3915: 3913: 3911: 3909: 3907: 3905: 3903: 3901: 3899: 3897: 3895: 3893: 3891: 3887: 3882: 3878: 3873: 3868: 3864: 3860: 3856: 3852: 3848: 3841: 3838: 3833: 3829: 3825: 3821: 3817: 3813: 3809: 3805: 3804:Life Sciences 3798: 3796: 3792: 3787: 3783: 3778: 3773: 3768: 3763: 3759: 3755: 3751: 3744: 3741: 3736: 3732: 3728: 3724: 3720: 3716: 3709: 3707: 3705: 3703: 3701: 3697: 3692: 3688: 3683: 3678: 3673: 3668: 3664: 3660: 3656: 3649: 3647: 3645: 3643: 3641: 3637: 3632: 3628: 3623: 3618: 3614: 3610: 3606: 3602: 3598: 3591: 3589: 3587: 3585: 3583: 3581: 3579: 3577: 3575: 3573: 3571: 3569: 3567: 3565: 3563: 3559: 3554: 3550: 3545: 3540: 3535: 3530: 3526: 3522: 3518: 3511: 3509: 3507: 3505: 3503: 3501: 3499: 3497: 3493: 3488: 3484: 3480: 3476: 3472: 3468: 3464: 3460: 3456: 3452: 3445: 3443: 3439: 3434: 3430: 3426: 3422: 3418: 3414: 3410: 3406: 3399: 3396: 3391: 3387: 3382: 3377: 3373: 3369: 3365: 3361: 3357: 3350: 3348: 3346: 3344: 3342: 3340: 3338: 3336: 3334: 3332: 3330: 3328: 3326: 3324: 3322: 3320: 3318: 3316: 3314: 3312: 3310: 3308: 3306: 3304: 3302: 3300: 3296: 3291: 3287: 3282: 3277: 3273: 3269: 3265: 3258: 3256: 3254: 3252: 3250: 3248: 3246: 3242: 3237: 3233: 3228: 3223: 3218: 3213: 3209: 3205: 3201: 3194: 3192: 3190: 3188: 3186: 3184: 3182: 3180: 3178: 3176: 3174: 3172: 3170: 3166: 3161: 3157: 3153: 3149: 3145: 3141: 3134: 3132: 3130: 3128: 3126: 3124: 3122: 3118: 3113: 3109: 3103: 3100: 3095: 3091: 3085: 3082: 3078: 3074: 3069: 3067: 3065: 3061: 3057: 3053: 3048: 3046: 3044: 3040: 3034: 3028: 3025: 3022: 3019: 3018: 3015: 3012: 3009: 3006: 3005: 3002: 2999: 2996: 2994: 2991: 2990: 2987: 2984: 2981: 2978: 2977: 2974: 2971: 2968: 2965: 2964: 2961: 2958: 2955: 2952: 2951: 2948: 2945: 2942: 2939: 2938: 2935: 2933: 2929: 2926: 2923: 2922: 2919: 2916: 2913: 2910: 2909: 2906: 2903: 2900: 2897: 2896: 2893: 2890: 2887: 2884: 2883: 2880: 2877: 2874: 2871: 2870: 2867: 2865: 2861: 2858: 2855: 2854: 2851: 2849: 2845: 2842: 2839: 2838: 2835: 2832: 2829: 2826: 2825: 2822: 2819: 2816: 2813: 2812: 2809: 2807: 2806:interactions 2803: 2800: 2797: 2796: 2793: 2790: 2787: 2784: 2783: 2780: 2777: 2774: 2771: 2770: 2767: 2764: 2761: 2758: 2757: 2754: 2752: 2748: 2745: 2742: 2741: 2738: 2735: 2732: 2729: 2728: 2725: 2722: 2719: 2716: 2715: 2712: 2710: 2706: 2703: 2700: 2699: 2695: 2692: 2689: 2686: 2685: 2679: 2672: 2670: 2668: 2664: 2657: 2647: 2644: 2638: 2628: 2626: 2619: 2617: 2615: 2606: 2604: 2602: 2598: 2594: 2590: 2586: 2581: 2579: 2575: 2571: 2567: 2563: 2559: 2555: 2551: 2547: 2543: 2539: 2535: 2531: 2527: 2520: 2518: 2515: 2514:breast cancer 2511: 2507: 2503: 2498: 2495: 2494:Wnt signaling 2491: 2487: 2483: 2481: 2472: 2465: 2463: 2461: 2456: 2454: 2449: 2445: 2441: 2436: 2434: 2431: 2427: 2423: 2415: 2413: 2411: 2407: 2403: 2399: 2395: 2394:breast cancer 2391: 2383: 2376: 2373: 2370: 2369: 2365: 2362: 2359: 2358: 2354: 2351: 2348: 2347: 2343: 2340: 2337: 2336: 2332: 2329: 2326: 2325: 2321: 2318: 2315: 2314: 2310: 2307: 2304: 2303: 2299: 2296: 2293: 2292: 2288: 2285: 2282: 2281: 2277: 2274: 2271: 2270: 2264: 2262: 2255: 2250: 2248: 2246: 2242: 2238: 2234: 2230: 2226: 2222: 2217: 2214: 2209: 2205: 2201: 2197: 2193: 2189: 2184: 2182: 2178: 2174: 2170: 2169:endonucleases 2166: 2162: 2158: 2153: 2150: 2145: 2140: 2138: 2134: 2130: 2126: 2123:phase of the 2122: 2113: 2106: 2104: 2102: 2098: 2088: 2084: 2077: 2075: 2073: 2072:glycosylation 2069: 2065: 2057: 2049: 2046: 2044: 2041: 2038: 2036: 2033: 2031: 2028: 2026: 2023: 2021: 2018: 2016: 2013: 2011: 2002: 1999: 1997: 1994: 1992: 1989: 1987: 1984: 1982: 1979: 1977: 1974: 1972: 1969: 1968: 1967: 1960: 1957: 1954: 1952: 1949: 1947: 1944: 1942: 1939: 1937: 1934: 1932: 1929: 1927: 1924: 1922: 1919: 1917: 1914: 1912: 1909: 1907: 1904: 1902: 1899: 1897: 1894: 1892: 1889: 1888: 1887: 1880: 1877: 1875: 1872: 1870: 1867: 1865: 1862: 1860: 1857: 1855: 1852: 1850: 1847: 1845: 1842: 1840: 1837: 1835: 1832: 1830: 1827: 1825: 1822: 1820: 1817: 1814: 1812:DNA2 helicase 1811: 1810: 1809: 1802: 1799: 1797: 1794: 1791: 1788: 1785: 1782: 1780: 1777: 1775: 1772: 1770: 1767: 1765: 1762: 1760: 1757: 1755: 1752: 1750: 1747: 1745: 1742: 1740: 1737: 1735: 1732: 1729: 1728: 1727: 1726: 1723: 1722: 1715: 1713: 1711: 1707: 1701: 1695: 1693: 1691: 1687: 1683: 1679: 1674: 1668: 1660: 1654: 1650: 1648: 1644: 1637: 1629: 1627: 1625: 1621: 1610: 1608: 1600: 1598: 1595: 1590: 1586: 1578: 1572: 1568: 1563: 1555: 1553: 1546: 1544: 1542: 1538: 1534: 1533:schizophrenia 1530: 1526: 1522: 1518: 1514: 1510: 1506: 1502: 1497: 1494: 1490: 1486: 1485:transcription 1482: 1478: 1475: 1471: 1467: 1463: 1459: 1455: 1451: 1439: 1434: 1430: 1426: 1423: 1419: 1412: 1410: 1407: 1403: 1399: 1395: 1392: 1388: 1384: 1377: 1371: 1367: 1364: 1358: 1356: 1352: 1346: 1342: 1339: 1335: 1328: 1326: 1320: 1316: 1313: 1307: 1305: 1301: 1295: 1291: 1288: 1286:RefSeq (mRNA) 1284: 1277: 1276: 1271: 1267: 1264: 1258: 1257: 1252: 1248: 1245: 1243: 1239: 1232: 1231: 1226: 1222: 1219: 1213: 1212: 1207: 1203: 1200: 1198: 1194: 1187: 1186: 1181: 1177: 1174: 1168: 1167: 1162: 1158: 1155: 1153: 1149: 1146: 1143: 1141: 1138: 1134: 1131: 1127: 1123: 1116: 1112: 1107: 1101: 1098: 1096: 1093: 1091: 1088: 1086: 1083: 1081: 1078: 1076: 1073: 1071: 1068: 1066: 1063: 1061: 1058: 1056: 1053: 1051: 1048: 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1348: 1325:NM_001025432 1322: 1300:NM_001079846 1297: 1273: 1254: 1228: 1209: 1183: 1164: 1144: 1139: 934:nuclear body 718:ciliary body 702:cumulus cell 690:aortic valve 594: 587: 314:External IDs 89: 5886:PDB gallery 5751:: 708–717. 3210:: 8168791. 2969:In silicon 2927:In silicon 2788:In silicon 2775:In silicon 2558:β-oxidation 2554:lipogenesis 2480:lung cancer 2398:lung cancer 2048:Zta (BZLF1) 1708:, p53, and 1636:Bromodomain 1630:Bromodomain 1562:Zinc finger 1517:lipogenesis 1503:as well as 1470:coactivator 919:nucleoplasm 823:p53 binding 813:MRF binding 648:skin of hip 620:sural nerve 292:Identifiers 6509:Categories 5814:Drosophila 5309:IUBMB Life 5130:2021-12-04 4983:: 105702. 4880:(7): 968. 4773:: 687515. 3810:: 118020. 3457:: 112861. 3079:, May 2017 3058:, May 2017 3035:References 2696:Reference 2643:Huntingtin 2548:(T2D) and 2442:(AML) and 2241:DNA damage 2225:DNA repair 2208:proteasome 2129:MAP Kinase 1607:KIX domain 1541:depression 598:(ortholog) 553:4,031,861 540:3,899,192 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