335:
312:
209:
234:
3581:
586:
341:
240:
3609:
42:
1244:
XPO1 mediates NES-dependent protein transport. It exports several hundreds of different proteins from the nucleus. XPO1 is involved in the nuclear export of ribosomal subunits. XPO1 plays a role in export of various RNAs including U snRNAs, rRNAs (as a part of ribosomal subunits), and some mRNAs.
68:
1472:"Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery"
2636:"The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)"
3249:
Kanai M, Hanashiro K, Kim SH, Hanai S, Boulares AH, Miwa M, Fukasawa K (September 2007). "Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation".
348:
247:
2613:
3580:
934:
915:
170:
2498:
Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L (October 2019).
3678:
1452:
3654:
3560:
1434:
1228:
in a genetic screen, and investigators determined that it was involved in control of the chromosome structure. It was later shown to be the
3673:
334:
3292:
Shao C, Lu C, Chen L, Koty PP, Cobos E, Gao W (August 2010). "p53-Dependent anticancer effects of leptomycin B on lung adenocarcinoma".
1149:
1142:
311:
65:
1421:
1400:
1236:). The structural details of the interaction of XPO1 with its cargos were revealed two decades after the gene was identified.
1417:
233:
208:
2716:
Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003).
1396:
1270:
150:
1282:
2718:"CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis"
347:
246:
3647:
3553:
340:
239:
1924:
Güttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Görlich D (November 2010).
3053:"The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1"
979:
158:
2952:"A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export"
2859:"Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway"
960:
3104:"Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import"
1373:
1233:
2109:"Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins"
3640:
3546:
1926:"NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1"
1815:
1750:
1591:
222:
137:
3202:"A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis"
1253:
XPO1 is involved in various viral infections. For example, it is required for the nuclear export of
1121:
1070:
2050:"A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning"
3317:
3274:
3182:
3133:
2372:
1971:
1784:
1623:
182:
2677:"Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export"
1125:
1100:
1074:
1049:
3514:
3469:
3448:"Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential"
3434:
3399:
3370:"Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1"
3356:
3309:
3266:
3231:
3174:
3125:
3084:
3033:
2981:
2932:
2880:
2839:
2788:
2747:
2698:
2657:
2594:
2576:
2537:
2519:
2480:
2462:
2421:
2413:
2364:
2356:
2317:
2299:
2260:
2242:
2203:
2185:
2166:"Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit"
2146:
2128:
2089:
2071:
2030:
2012:
1963:
1955:
1906:
1888:
1849:
1831:
1776:
1768:
1739:"Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP"
1719:
1711:
1672:
1664:
1615:
1607:
1560:
1552:
1511:
1493:
1368:
1229:
130:
58:
3624:
1991:"Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry"
3504:
3494:
3459:
3424:
3389:
3381:
3348:
3301:
3258:
3221:
3213:
3164:
3115:
3074:
3064:
3023:
3015:
2971:
2963:
2922:
2914:
2870:
2829:
2819:
2778:
2737:
2729:
2688:
2647:
2584:
2568:
2527:
2511:
2470:
2452:
2403:
2348:
2307:
2291:
2250:
2234:
2193:
2177:
2136:
2120:
2079:
2061:
2020:
2002:
1945:
1937:
1896:
1880:
1839:
1823:
1758:
1703:
1654:
1599:
1542:
1501:
1483:
427:
358:
302:
257:
1950:
1216:), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
585:
402:
178:
2223:"Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2"
2048:
Kırlı K, Karaca S, Dehne HJ, Samwer M, Pan KT, Lenz C, Urlaub H, Görlich D (2015-12-17).
3413:"Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions"
1819:
1754:
1595:
1578:
Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E (1997-11-20).
3509:
3482:
3394:
3369:
2976:
2951:
2927:
2902:
2834:
2807:
2589:
2556:
2532:
2499:
2475:
2440:
2255:
2222:
2198:
2165:
2084:
2049:
2025:
1990:
1901:
1868:
1844:
1803:
1580:"CRM1 is responsible for intracellular transport mediated by the nuclear export signal"
1506:
1471:
1314:
3226:
3201:
3169:
3152:
3120:
3103:
2742:
2717:
2221:
Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE, Kutay U (2009-06-29).
2141:
2108:
1659:
1642:
1547:
1530:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
652:
647:
642:
637:
632:
627:
3667:
3352:
3028:
3019:
3003:
2312:
2295:
2279:
1332:
614:
3321:
3278:
3186:
3137:
2572:
2376:
1975:
1788:
1261:, an event that is a crucial part of the infection cycle. XPO1 is affected in some
162:
3620:
3339:
Görlich D, Kutay U (1999). "Transport between the cell nucleus and the cytoplasm".
1627:
420:
199:
3464:
3447:
1869:"Structural basis for assembly and disassembly of the CRM1 nuclear export complex"
2515:
1707:
1265:
types and is therefore viewed as a target for development of anti-cancer drugs.
186:
2767:"The GTP-binding domain of class II transactivator regulates its nuclear export"
1802:
Dong X, Biswas A, Süel KE, Jackson LK, Martinez R, Gu H, Chook YM (2009-04-30).
1737:
Monecke T, Güttler T, Neumann P, Dickmanns A, Görlich D, Ficner R (2009-05-22).
1457:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1439:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1358:
2808:"Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator"
2783:
2766:
503:
3305:
2903:"Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export"
2408:
2391:
1290:
319:
216:
166:
3499:
3069:
3052:
2675:
Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI (April 2002).
2580:
2523:
2466:
2441:"The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA"
2417:
2360:
2303:
2246:
2189:
2132:
2075:
2016:
1959:
1892:
1835:
1804:"Structural basis for leucine-rich nuclear export signal recognition by CRM1"
1772:
1715:
1668:
1611:
1556:
1497:
3217:
2733:
2007:
1763:
1738:
1266:
1258:
879:
563:
441:
386:
373:
285:
272:
174:
3518:
3473:
3438:
3403:
3360:
3313:
3270:
3235:
3129:
3088:
3037:
3004:"Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1"
2985:
2936:
2918:
2884:
2843:
2824:
2792:
2751:
2702:
2693:
2676:
2661:
2652:
2635:
2598:
2541:
2484:
2425:
2368:
2321:
2264:
2207:
2181:
2150:
2124:
2093:
2034:
1967:
1925:
1910:
1853:
1780:
1488:
3429:
3412:
3178:
2967:
2336:
2238:
1723:
1691:
1676:
1619:
1579:
1564:
1515:
1189:
1184:
3385:
1363:
1173:
1024:
1005:
2457:
2066:
1827:
3079:
2950:
Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (May 1999).
1692:"Evidence for a role of CRM1 in signal-mediated nuclear protein export"
1338:
991:
946:
3102:
Lindsay ME, Plafker K, Smith AE, Clurman BE, Macara IG (August 2002).
2875:
2858:
2500:"Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis"
1941:
1884:
107:
103:
99:
95:
91:
87:
41:
3534:
3D electron microscopy structures of CRM1 from the EM Data Bank(EMDB)
1326:
1320:
1296:
1262:
1157:
901:
3608:
3533:
3262:
3153:"CRM1 is an export receptor for leucine-rich nuclear export signals"
2901:
Lindsay ME, Holaska JM, Welch K, Paschal BM, Macara IG (June 2001).
2352:
1531:"CRM1 is an export receptor for leucine-rich nuclear export signals"
17:
3589:: PROTEOLYTIC FRAGMENT OF CRM1 SPANNING SIX C-TERMINAL HEAT REPEATS
2614:"FDA grants accelerated approval to selinexor for multiple myeloma"
1989:
Thakar K, Karaca S, Port SA, Urlaub H, Kehlenbach RH (March 2013).
1603:
1302:
1254:
3051:
Singh BB, Patel HH, Roepman R, Schick D, Ferreira PA (Dec 1999).
864:
860:
3616:
2557:"Atomic basis of CRM1-cargo recognition, release and inhibition"
2439:
Booth DS, Cheng Y, Frankel AD (2014-12-08). Sundquist WI (ed.).
1308:
154:
3542:
2392:"Nucleocytoplasmic Transport of RNAs and RNA–Protein Complexes"
594:
3538:
1344:
1232:
receptor for cargos with leucine-rich nuclear export signals (
2765:
Raval A, Weissman JD, Howcroft TK, Singer DS (January 2003).
2634:
Tickenbrock L, Cramer J, Vetter IR, Muller O (August 2002).
3151:
Fornerod M, Ohno M, Yoshida M, Mattaj IW (September 1997).
2806:
Voong LN, Slater AR, Kratovac S, Cressman DE (April 2008).
1224:
XPO1 (CRM1) originally was identified in the fission yeast
1690:
Ossareh-Nazari B, Bachelerie F, Dargemont C (1997-10-03).
1643:"Exportin 1 (Crm1p) is an essential nuclear export factor"
1269:, a drug specifically targeting XPO1, was approved by the
3200:
Craig E, Zhang ZK, Davies KP, Kalpana GV (January 2002).
785:
negative regulation of transcription by RNA polymerase II
410:
3628:
1529:
Fornerod M, Ohno M, Yoshida M, Mattaj IW (1997-09-19).
575:
3411:
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006).
1114:
1093:
1063:
1042:
1641:Stade K, Ford CS, Guthrie C, Weis K (1997-09-19).
1413:
1411:
1409:
1392:
1390:
1388:
2337:"Exporting RNA from the nucleus to the cytoplasm"
357:
256:
2390:Sloan KE, Gleizes PE, Bohnsack MT (2016-05-22).
2997:
2995:
2896:
2894:
2629:
2627:
29:Protein-coding gene in the species Homo sapiens
1418:GRCm38: Ensembl release 89: ENSMUSG00000020290
3648:
3554:
2164:Ho JH, Kallstrom G, Johnson AW (2000-11-27).
8:
1397:GRCh38: Ensembl release 89: ENSG00000082898
810:ribosomal large subunit export from nucleus
760:ribosomal small subunit export from nucleus
3655:
3641:
3561:
3547:
3539:
875:
610:
398:
297:
194:
76:
3508:
3498:
3463:
3428:
3393:
3225:
3168:
3119:
3078:
3068:
3027:
2975:
2926:
2874:
2833:
2823:
2782:
2741:
2692:
2651:
2588:
2531:
2474:
2456:
2407:
2311:
2254:
2197:
2140:
2083:
2065:
2024:
2006:
1949:
1930:Nature Structural & Molecular Biology
1900:
1873:Nature Structural & Molecular Biology
1843:
1762:
1658:
1546:
1505:
1487:
835:regulation of protein export from nucleus
689:intracellular membrane-bounded organelle
3576:
3483:"CRM1 inhibitors for antiviral therapy"
1867:Dong X, Biswas A, Chook YM (May 2009).
1384:
795:regulation of protein catabolic process
653:nuclear export signal receptor activity
3446:Stauber RH, Mann W, Knauer SK (2007).
1257:RNA in complex with the viral protein
648:structural constituent of nuclear pore
31:
2341:Nature Reviews Molecular Cell Biology
830:ribosomal subunit export from nucleus
362:
323:
318:
261:
220:
215:
7:
3605:
3603:
770:regulation of centrosome duplication
141:, CRM1, emb, exp1, exportin 1, CRM-1
1995:Molecular & Cellular Proteomics
1470:Adachi Y, Yanagida M (1989-04-01).
1273:for treatment of multiple myeloma.
3627:. You can help Knowledge (XXG) by
1111:
1090:
1060:
1039:
1015:
996:
970:
951:
925:
906:
744:intracellular anatomical structure
580:
498:
436:
415:
25:
3002:Plafker K, Macara IG (May 2000).
2555:Fung HY, Chook YM (August 2014).
2335:Köhler A, Hurt E (October 2007).
3607:
3579:
3353:10.1146/annurev.cellbio.15.1.607
3020:10.1128/mcb.20.10.3510-3521.2000
2296:10.1128/mcb.20.12.4181-4187.2000
2107:Moy TI, Silver PA (1999-08-15).
1210:chromosomal region maintenance 1
765:intracellular transport of virus
584:
346:
339:
333:
310:
245:
238:
232:
207:
40:
2857:Thomas F, Kutay U (June 2003).
2573:10.1016/j.semcancer.2014.03.002
815:intracellular protein transport
800:protein localization to nucleus
628:protein domain specific binding
2284:Molecular and Cellular Biology
1951:11858/00-001M-0000-0012-D4DB-B
595:More reference expression data
564:More reference expression data
1:
3679:Human chromosome 2 gene stubs
3481:Mathew C, Ghildyal R (2017).
3465:10.1158/0008-5472.CAN-07-0494
3170:10.1016/s0092-8674(00)80371-2
3121:10.1016/s0092-8674(02)00836-x
2280:"Nuclear RNA export pathways"
1660:10.1016/s0092-8674(00)80370-0
1548:10.1016/s0092-8674(00)80371-2
331:
230:
2516:10.1158/2159-8290.CD-19-0298
2396:Journal of Molecular Biology
1708:10.1126/science.278.5335.141
780:regulation of mRNA stability
3674:Genes on human chromosome 2
3294:Cancer Chemother. Pharmacol
2227:The Journal of Cell Biology
2170:The Journal of Cell Biology
850:nucleocytoplasmic transport
790:protein export from nucleus
3695:
3602:
3368:Budhu AS, Wang XW (2007).
2784:10.4049/jimmunol.170.2.922
2612:Research Cf (2019-12-20).
2561:Seminars in Cancer Biology
734:protein-containing complex
3574:
3487:Frontiers in Microbiology
3341:Annu. Rev. Cell Dev. Biol
3306:10.1007/s00280-010-1434-6
2409:10.1016/j.jmb.2015.09.023
1453:"Mouse PubMed Reference:"
1435:"Human PubMed Reference:"
1226:Schizosaccharomyces pombe
1188:
1183:
1179:
1172:
1156:
1137:
1118:
1097:
1086:
1067:
1046:
1035:
1022:
1018:
1003:
999:
990:
977:
973:
958:
954:
945:
932:
928:
913:
909:
900:
885:
878:
874:
858:
825:sister chromatid cohesion
739:ribonucleoprotein complex
613:
609:
592:
583:
574:
561:
550:medullary collecting duct
510:
501:
464:epithelium of nasopharynx
448:
439:
409:
401:
397:
380:
367:
330:
309:
300:
296:
279:
266:
229:
206:
197:
193:
148:
145:
135:
128:
123:
84:
79:
62:
57:
52:
48:
39:
34:
3500:10.3389/fmicb.2017.01171
3070:10.1074/jbc.274.52.37370
1150:Chr 11: 23.21 – 23.25 Mb
2734:10.1091/mbc.E02-06-0319
2278:Cullen BR (June 2000).
2113:Genes & Development
2008:10.1074/mcp.M112.024877
1764:10.1126/science.1173388
1476:Journal of Cell Biology
1281:XPO1 has been shown to
1143:Chr 2: 61.48 – 61.54 Mb
2919:10.1083/jcb.153.7.1391
2825:10.1074/jbc.M706487200
2694:10.1074/jbc.C100762200
2653:10.1074/jbc.M203990200
2182:10.1083/jcb.151.5.1057
2125:10.1101/gad.13.16.2118
1489:10.1083/jcb.108.4.1195
3430:10.1038/sj.cr.7290370
3218:10.1093/emboj/21.1.31
2968:10.1083/jcb.145.4.645
2239:10.1083/jcb.200904048
1374:Nuclear export signal
546:mandibular prominence
488:palpebral conjunctiva
325:Chromosome 11 (mouse)
3386:10.4161/cc.4.11.2187
633:transporter activity
223:Chromosome 2 (human)
80:List of PDB id codes
53:Available structures
2458:10.7554/eLife.04121
2067:10.7554/eLife.11466
1828:10.1038/nature07975
1820:2009Natur.458.1136D
1814:(7242): 1136–1141.
1755:2009Sci...324.1087M
1749:(5930): 1087–1091.
1596:1997Natur.390..308F
840:ribosome biogenesis
460:germinal epithelium
3615:This article on a
2869:(Pt 12): 2409–19.
980:ENSMUSG00000020290
753:Biological process
662:Cellular component
621:Molecular function
3636:
3635:
3597:
3596:
3458:(13): 5999–6002.
3423:(11–12): 923–34.
2876:10.1242/jcs.00464
2510:(10): 1452–1467.
2402:(10): 2040–2059.
2290:(12): 4181–4187.
2119:(16): 2118–2133.
1942:10.1038/nsmb.1931
1936:(11): 1367–1376.
1885:10.1038/nsmb.1586
1702:(5335): 141–144.
1590:(6657): 308–311.
1369:Nuclear transport
1249:Medical relevance
1230:nuclear transport
1208:), also known as
1199:
1198:
1195:
1194:
1168:
1167:
1133:
1132:
1108:
1107:
1082:
1081:
1057:
1056:
1031:
1030:
1012:
1011:
986:
985:
967:
966:
941:
940:
922:
921:
870:
869:
805:protein transport
704:lamellae anulatae
605:
604:
601:
600:
570:
569:
557:
556:
495:
494:
393:
392:
292:
291:
119:
118:
115:
114:
63:Ortholog search:
16:(Redirected from
3686:
3657:
3650:
3643:
3611:
3604:
3583:
3563:
3556:
3549:
3540:
3522:
3512:
3502:
3477:
3467:
3442:
3432:
3407:
3397:
3364:
3326:
3325:
3289:
3283:
3282:
3246:
3240:
3239:
3229:
3197:
3191:
3190:
3172:
3148:
3142:
3141:
3123:
3099:
3093:
3092:
3082:
3072:
3048:
3042:
3041:
3031:
2999:
2990:
2989:
2979:
2947:
2941:
2940:
2930:
2898:
2889:
2888:
2878:
2854:
2848:
2847:
2837:
2827:
2803:
2797:
2796:
2786:
2762:
2756:
2755:
2745:
2713:
2707:
2706:
2696:
2672:
2666:
2665:
2655:
2631:
2622:
2621:
2609:
2603:
2602:
2592:
2552:
2546:
2545:
2535:
2504:Cancer Discovery
2495:
2489:
2488:
2478:
2460:
2436:
2430:
2429:
2411:
2387:
2381:
2380:
2332:
2326:
2325:
2315:
2275:
2269:
2268:
2258:
2233:(7): 1167–1180.
2218:
2212:
2211:
2201:
2176:(5): 1057–1066.
2161:
2155:
2154:
2144:
2104:
2098:
2097:
2087:
2069:
2045:
2039:
2038:
2028:
2010:
1986:
1980:
1979:
1953:
1921:
1915:
1914:
1904:
1864:
1858:
1857:
1847:
1799:
1793:
1792:
1766:
1734:
1728:
1727:
1687:
1681:
1680:
1662:
1653:(6): 1041–1050.
1638:
1632:
1631:
1575:
1569:
1568:
1550:
1541:(6): 1051–1060.
1526:
1520:
1519:
1509:
1491:
1482:(4): 1195–1207.
1467:
1461:
1460:
1449:
1443:
1442:
1431:
1425:
1415:
1404:
1394:
1181:
1180:
1152:
1145:
1128:
1112:
1103:
1091:
1087:RefSeq (protein)
1077:
1061:
1052:
1040:
1016:
997:
971:
952:
926:
907:
876:
694:nuclear envelope
679:nuclear membrane
611:
597:
588:
581:
566:
522:genital tubercle
518:primitive streak
506:
504:Top expressed in
499:
456:ventricular zone
444:
442:Top expressed in
437:
416:
399:
389:
376:
365:
350:
343:
337:
326:
314:
298:
288:
275:
264:
249:
242:
236:
225:
211:
195:
189:
187:XPO1 - orthologs
140:
133:
110:
77:
71:
50:
49:
44:
32:
21:
3694:
3693:
3689:
3688:
3687:
3685:
3684:
3683:
3664:
3663:
3662:
3661:
3600:
3598:
3593:
3590:
3584:
3570:
3567:
3530:
3525:
3480:
3445:
3410:
3367:
3338:
3334:
3332:Further reading
3329:
3291:
3290:
3286:
3263:10.1038/ncb1638
3257:(10): 1175–83.
3248:
3247:
3243:
3199:
3198:
3194:
3150:
3149:
3145:
3101:
3100:
3096:
3063:(52): 37370–8.
3050:
3049:
3045:
3014:(10): 3510–21.
3008:Mol. Cell. Biol
3001:
3000:
2993:
2949:
2948:
2944:
2913:(7): 1391–402.
2900:
2899:
2892:
2856:
2855:
2851:
2805:
2804:
2800:
2764:
2763:
2759:
2722:Mol. Biol. Cell
2715:
2714:
2710:
2687:(17): 14355–8.
2674:
2673:
2669:
2646:(35): 32332–8.
2633:
2632:
2625:
2611:
2610:
2606:
2554:
2553:
2549:
2497:
2496:
2492:
2438:
2437:
2433:
2389:
2388:
2384:
2353:10.1038/nrm2255
2347:(10): 761–773.
2334:
2333:
2329:
2277:
2276:
2272:
2220:
2219:
2215:
2163:
2162:
2158:
2106:
2105:
2101:
2047:
2046:
2042:
1988:
1987:
1983:
1923:
1922:
1918:
1866:
1865:
1861:
1801:
1800:
1796:
1736:
1735:
1731:
1689:
1688:
1684:
1640:
1639:
1635:
1577:
1576:
1572:
1528:
1527:
1523:
1469:
1468:
1464:
1451:
1450:
1446:
1433:
1432:
1428:
1416:
1407:
1395:
1386:
1382:
1355:
1350:
1279:
1251:
1242:
1222:
1190:View/Edit Mouse
1185:View/Edit Human
1148:
1141:
1138:Location (UCSC)
1124:
1120:
1099:
1073:
1069:
1048:
961:ENSG00000082898
854:
748:
657:
638:protein binding
593:
562:
553:
548:
544:
540:
536:
532:
528:
524:
520:
516:
502:
491:
486:
484:trabecular bone
482:
478:
474:
472:visceral pleura
470:
468:parietal pleura
466:
462:
458:
454:
440:
384:
371:
364:11|11 A3.2
363:
353:
352:
351:
344:
324:
301:Gene location (
283:
270:
262:
252:
251:
250:
243:
221:
198:Gene location (
149:
136:
129:
86:
64:
30:
23:
22:
15:
12:
11:
5:
3692:
3690:
3682:
3681:
3676:
3666:
3665:
3660:
3659:
3652:
3645:
3637:
3634:
3633:
3612:
3595:
3594:
3592:
3591:
3585:
3578:
3575:
3572:
3571:
3568:
3566:
3565:
3558:
3551:
3543:
3537:
3536:
3529:
3528:External links
3526:
3524:
3523:
3478:
3443:
3408:
3380:(11): 1510–4.
3365:
3335:
3333:
3330:
3328:
3327:
3300:(6): 1369–80.
3284:
3251:Nat. Cell Biol
3241:
3212:(1–2): 31–42.
3192:
3163:(6): 1051–60.
3143:
3094:
3043:
2991:
2942:
2890:
2849:
2818:(14): 9031–9.
2798:
2757:
2708:
2667:
2623:
2604:
2547:
2490:
2431:
2382:
2327:
2270:
2213:
2156:
2099:
2040:
2001:(3): 664–678.
1981:
1916:
1879:(5): 558–560.
1859:
1794:
1729:
1682:
1633:
1570:
1521:
1462:
1444:
1426:
1405:
1383:
1381:
1378:
1377:
1376:
1371:
1366:
1361:
1354:
1351:
1349:
1348:
1342:
1336:
1330:
1324:
1318:
1315:Nucleoporin 62
1312:
1306:
1300:
1294:
1287:
1278:
1275:
1250:
1247:
1241:
1238:
1221:
1218:
1197:
1196:
1193:
1192:
1187:
1177:
1176:
1170:
1169:
1166:
1165:
1163:
1161:
1154:
1153:
1146:
1139:
1135:
1134:
1131:
1130:
1116:
1115:
1109:
1106:
1105:
1095:
1094:
1088:
1084:
1083:
1080:
1079:
1065:
1064:
1058:
1055:
1054:
1044:
1043:
1037:
1033:
1032:
1029:
1028:
1020:
1019:
1013:
1010:
1009:
1001:
1000:
994:
988:
987:
984:
983:
975:
974:
968:
965:
964:
956:
955:
949:
943:
942:
939:
938:
930:
929:
923:
920:
919:
911:
910:
904:
898:
897:
892:
887:
883:
882:
872:
871:
868:
867:
856:
855:
853:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
775:mRNA transport
772:
767:
762:
756:
754:
750:
749:
747:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
607:
606:
603:
602:
599:
598:
590:
589:
578:
572:
571:
568:
567:
559:
558:
555:
554:
552:
551:
547:
543:
539:
535:
534:abdominal wall
531:
527:
523:
519:
515:
514:tail of embryo
511:
508:
507:
496:
493:
492:
490:
489:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
446:
445:
433:
432:
424:
413:
407:
406:
403:RNA expression
395:
394:
391:
390:
382:
378:
377:
369:
366:
361:
355:
354:
345:
338:
332:
328:
327:
322:
316:
315:
307:
306:
294:
293:
290:
289:
281:
277:
276:
268:
265:
260:
254:
253:
244:
237:
231:
227:
226:
219:
213:
212:
204:
203:
191:
190:
147:
143:
142:
134:
126:
125:
121:
120:
117:
116:
113:
112:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3691:
3680:
3677:
3675:
3672:
3671:
3669:
3658:
3653:
3651:
3646:
3644:
3639:
3638:
3632:
3630:
3626:
3622:
3618:
3613:
3610:
3606:
3601:
3588:
3582:
3577:
3573:
3564:
3559:
3557:
3552:
3550:
3545:
3544:
3541:
3535:
3532:
3531:
3527:
3520:
3516:
3511:
3506:
3501:
3496:
3492:
3488:
3484:
3479:
3475:
3471:
3466:
3461:
3457:
3453:
3449:
3444:
3440:
3436:
3431:
3426:
3422:
3418:
3414:
3409:
3405:
3401:
3396:
3391:
3387:
3383:
3379:
3375:
3371:
3366:
3362:
3358:
3354:
3350:
3347:(1): 607–60.
3346:
3342:
3337:
3336:
3331:
3323:
3319:
3315:
3311:
3307:
3303:
3299:
3295:
3288:
3285:
3280:
3276:
3272:
3268:
3264:
3260:
3256:
3252:
3245:
3242:
3237:
3233:
3228:
3223:
3219:
3215:
3211:
3207:
3203:
3196:
3193:
3188:
3184:
3180:
3176:
3171:
3166:
3162:
3158:
3154:
3147:
3144:
3139:
3135:
3131:
3127:
3122:
3117:
3114:(3): 349–60.
3113:
3109:
3105:
3098:
3095:
3090:
3086:
3081:
3076:
3071:
3066:
3062:
3058:
3057:J. Biol. Chem
3054:
3047:
3044:
3039:
3035:
3030:
3025:
3021:
3017:
3013:
3009:
3005:
2998:
2996:
2992:
2987:
2983:
2978:
2973:
2969:
2965:
2962:(4): 645–57.
2961:
2957:
2953:
2946:
2943:
2938:
2934:
2929:
2924:
2920:
2916:
2912:
2908:
2904:
2897:
2895:
2891:
2886:
2882:
2877:
2872:
2868:
2864:
2860:
2853:
2850:
2845:
2841:
2836:
2831:
2826:
2821:
2817:
2813:
2812:J. Biol. Chem
2809:
2802:
2799:
2794:
2790:
2785:
2780:
2777:(2): 922–30.
2776:
2772:
2768:
2761:
2758:
2753:
2749:
2744:
2739:
2735:
2731:
2728:(1): 201–13.
2727:
2723:
2719:
2712:
2709:
2704:
2700:
2695:
2690:
2686:
2682:
2681:J. Biol. Chem
2678:
2671:
2668:
2663:
2659:
2654:
2649:
2645:
2641:
2640:J. Biol. Chem
2637:
2630:
2628:
2624:
2619:
2615:
2608:
2605:
2600:
2596:
2591:
2586:
2582:
2578:
2574:
2570:
2566:
2562:
2558:
2551:
2548:
2543:
2539:
2534:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2501:
2494:
2491:
2486:
2482:
2477:
2472:
2468:
2464:
2459:
2454:
2450:
2446:
2442:
2435:
2432:
2427:
2423:
2419:
2415:
2410:
2405:
2401:
2397:
2393:
2386:
2383:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2331:
2328:
2323:
2319:
2314:
2309:
2305:
2301:
2297:
2293:
2289:
2285:
2281:
2274:
2271:
2266:
2262:
2257:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2217:
2214:
2209:
2205:
2200:
2195:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2160:
2157:
2152:
2148:
2143:
2138:
2134:
2130:
2126:
2122:
2118:
2114:
2110:
2103:
2100:
2095:
2091:
2086:
2081:
2077:
2073:
2068:
2063:
2059:
2055:
2051:
2044:
2041:
2036:
2032:
2027:
2022:
2018:
2014:
2009:
2004:
2000:
1996:
1992:
1985:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1952:
1947:
1943:
1939:
1935:
1931:
1927:
1920:
1917:
1912:
1908:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1863:
1860:
1855:
1851:
1846:
1841:
1837:
1833:
1829:
1825:
1821:
1817:
1813:
1809:
1805:
1798:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1765:
1760:
1756:
1752:
1748:
1744:
1740:
1733:
1730:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1686:
1683:
1678:
1674:
1670:
1666:
1661:
1656:
1652:
1648:
1644:
1637:
1634:
1629:
1625:
1621:
1617:
1613:
1609:
1605:
1604:10.1038/36894
1601:
1597:
1593:
1589:
1585:
1581:
1574:
1571:
1566:
1562:
1558:
1554:
1549:
1544:
1540:
1536:
1532:
1525:
1522:
1517:
1513:
1508:
1503:
1499:
1495:
1490:
1485:
1481:
1477:
1473:
1466:
1463:
1458:
1454:
1448:
1445:
1440:
1436:
1430:
1427:
1423:
1419:
1414:
1412:
1410:
1406:
1402:
1398:
1393:
1391:
1389:
1385:
1379:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1356:
1352:
1346:
1343:
1340:
1337:
1334:
1331:
1328:
1325:
1322:
1319:
1316:
1313:
1310:
1307:
1304:
1301:
1298:
1295:
1292:
1289:
1288:
1286:
1284:
1276:
1274:
1272:
1268:
1264:
1260:
1256:
1248:
1246:
1239:
1237:
1235:
1231:
1227:
1219:
1217:
1215:
1211:
1207:
1203:
1191:
1186:
1182:
1178:
1175:
1171:
1164:
1162:
1159:
1155:
1151:
1147:
1144:
1140:
1136:
1129:
1127:
1123:
1117:
1113:
1110:
1104:
1102:
1096:
1092:
1089:
1085:
1078:
1076:
1072:
1066:
1062:
1059:
1053:
1051:
1045:
1041:
1038:
1036:RefSeq (mRNA)
1034:
1027:
1026:
1021:
1017:
1014:
1008:
1007:
1002:
998:
995:
993:
989:
982:
981:
976:
972:
969:
963:
962:
957:
953:
950:
948:
944:
937:
936:
931:
927:
924:
918:
917:
912:
908:
905:
903:
899:
896:
893:
891:
888:
884:
881:
877:
873:
866:
862:
857:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
820:viral process
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
757:
755:
752:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
616:
615:Gene ontology
612:
608:
596:
591:
587:
582:
579:
577:
573:
565:
560:
549:
545:
541:
537:
533:
529:
526:Gonadal ridge
525:
521:
517:
513:
512:
509:
505:
500:
497:
487:
483:
479:
475:
471:
467:
463:
459:
455:
451:
450:
447:
443:
438:
435:
434:
431:
429:
425:
423:
422:
418:
417:
414:
412:
408:
404:
400:
396:
388:
383:
379:
375:
370:
360:
356:
349:
342:
336:
329:
321:
317:
313:
308:
304:
299:
295:
287:
282:
278:
274:
269:
259:
255:
248:
241:
235:
228:
224:
218:
214:
210:
205:
201:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
144:
139:
132:
127:
122:
111:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
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714:kinetochore
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643:RNA binding
542:human fetus
480:skin of hip
385:23,248,249
372:23,206,041
284:61,538,741
271:61,476,032
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1424:, May 2017
1403:, May 2017
1380:References
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2361:1471-0080
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2247:1540-8140
2190:0021-9525
2133:0890-9369
2076:2050-084X
2017:1535-9484
1960:1545-9985
1893:1545-9985
1836:1476-4687
1773:1095-9203
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1669:0092-8674
1612:0028-0836
1557:0092-8674
1498:0021-9525
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1101:NP_003391
1075:NM_134014
1050:NM_003400
880:Orthologs
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729:host cell
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3322:27127578
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3279:13433567
3271:17891139
3236:11782423
3187:15119502
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3130:12176322
3089:10601307
3038:10779340
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