360:
337:
2780:
2720:
2750:
234:
259:
2765:
2825:
625:
611:
2810:
2795:
618:
2735:
366:
265:
3513:
1351:
47:
2385:
Estrada S, Nycander M, Hill NJ, Craven CJ, Waltho JP, Björk I (May 1998). "The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin
73:
2779:
2719:
2349:
Pavlova A, Björk I (September 2003). "Grafting of features of cystatins C or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances inhibition of cysteine proteinases".
2749:
2112:
Vigneswaran N, Zhao W, Dassanayake A, Muller S, Miller DM, Zacharias W (August 2000). "Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer".
1334:, and thus it has an essential position for the proteolysis of extracellular matrix components, intercellular communication disruption, and reduced protease inhibitor expression.
2764:
373:
272:
3548:
2824:
1310:, where cathepsin B is formed. Mature cathepsin B is composed of a heavy chain of 25-26 kDa and a light chain of 5kDa, which are linked by a dimer of disulfide.
2865:
2809:
2794:
933:
195:
1740:"Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis"
914:
2788:: Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft
2734:
2728:: CRYSTAL STRUCTURE OF CATHEPSIN B INHIBITED WITH CA030 AT 2.1 ANGSTROMS RESOLUTION: A BASIS FOR THE DESIGN OF SPECIFIC EPOXYSUCCINYL INHIBITORS
2699:
1595:
31:
1830:"Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm"
1577:
3533:
1703:(February 1994). "Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene".
359:
70:
2323:
2306:
1184:
1177:
336:
3232:
1434:
2858:
2423:"Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases"
1976:
1941:
Qian F, Frankfater A, Chan SJ, Steiner DF (April 1991). "The structure of the mouse cathepsin B gene and its putative promoter".
1564:
1543:
1372:
1365:
3388:
1560:
258:
233:
1539:
1415:
2758:: THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY
1261:. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions.
1387:
175:
3016:
3011:
2851:
1460:
1299:
2307:"Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D"
372:
271:
3503:
2205:
Bian B, Mongrain S, Cagnol S, Langlois MJ, Boulanger J, Bernatchez G, Carrier JC, Boudreau F, Rivard N (May 2016).
1394:
3373:
3489:
3476:
3463:
3450:
3437:
3424:
3411:
2885:
2692:
365:
264:
3383:
3337:
3280:
2882:
2671:
1319:
982:
183:
2560:
Murata M, Miyashita S, Yokoo C, Tamai M, Hanada K, Hatayama K, Towatari T, Nikawa T, Katunuma N (March 1991).
2065:"uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells"
1401:
3285:
3076:
1361:
963:
959:
3306:
3225:
1383:
3378:
2613:
Yan S, Sloane BF (June 2003). "Molecular regulation of human cathepsin B: implication in pathologies".
2685:
2256:"Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients"
1895:
1653:
247:
1286:. The promoter of CTSB gene contains a GC-rich region including many SP1 sites, which is similar to
162:
3553:
3342:
3169:
1254:
and plays an important role in intracellular proteolysis. In humans, cathepsin B is encoded by the
1113:
1072:
1884:"Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma"
3543:
3538:
3275:
2638:
2591:
2042:
1642:"Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs"
1306:
with a signal peptide of 17 amino acids. Procathepsin B of 43/46 kDa is then transported to the
1251:
1247:
207:
1789:"Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes"
1613:
Sloane BF (April 1990). "Cathepsin B and cystatins: evidence for a role in cancer progression".
1160:
1139:
1129:
1125:
1121:
1117:
1093:
1062:
1058:
1054:
1050:
1046:
2878:
2630:
2583:
2542:
2493:
2452:
2403:
2367:
2328:
2287:
2236:
2187:
2169:
2130:
2094:
2034:
1999:
1958:
1923:
1861:
1810:
1769:
1720:
1681:
1622:
1287:
155:
63:
1990:
Kirschke H, Barrett AJ, Rawlings ND (1995). "Proteinases 1: lysosomal cysteine proteinases".
1290:. At least five transcript variants encoding the same protein have been found for this gene.
3321:
3316:
3290:
3218:
3189:
3081:
3071:
3066:
3061:
3056:
2843:
2622:
2573:
2532:
2524:
2483:
2442:
2434:
2395:
2359:
2318:
2277:
2267:
2226:
2218:
2177:
2161:
2122:
2084:
2076:
2026:
1950:
1913:
1903:
1851:
1841:
1800:
1759:
1751:
1712:
1671:
1661:
1504:
1492:
624:
610:
452:
383:
327:
282:
3036:
2662:
2472:"Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells"
3368:
3352:
3265:
1327:
1307:
617:
427:
203:
1408:
1899:
1657:
3517:
3406:
3347:
2667:
2537:
2512:
2447:
2422:
2282:
2255:
2231:
2206:
2182:
2149:
2089:
2064:
1918:
1883:
1856:
1829:
1764:
1739:
1240:
2030:
1676:
1641:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
706:
701:
696:
691:
686:
681:
676:
671:
666:
3527:
3311:
3270:
2578:
2561:
1716:
1700:
653:
2642:
2595:
2254:
Ruan J, Zheng H, Rong X, Rong X, Zhang J, Fang W, Zhao P, Luo R (20 February 2016).
2046:
1451:. Overexpression of cathepsin B is correlated with invasive and metastatic cancers.
1447:
Cathepsin B has been proposed as a potentially effective biomarker for a variety of
3260:
3128:
3124:
1279:
445:
224:
2773:: CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION
1738:
Tong B, Wan B, Wei Z, Wang T, Zhao P, Dou Y, Lv Z, Xia Y, Dai Y (September 2014).
187:
1908:
211:
3484:
3419:
3255:
3199:
3194:
3164:
3148:
3143:
3138:
3133:
3119:
3114:
3109:
3104:
1600:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1582:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1499:
1467:
1350:
1331:
3512:
1805:
1788:
1646:
Proceedings of the
National Academy of Sciences of the United States of America
528:
3179:
2993:
2962:
2957:
2952:
2947:
2833:: REFINED CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 2.5 ANGSTROM RESOLUTION
2272:
2207:"Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis"
2080:
1478:
1472:
1303:
344:
241:
191:
2562:"Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro"
2488:
2471:
2173:
3458:
3432:
3184:
3091:
3046:
3041:
3031:
3021:
2988:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
1954:
1846:
1666:
1540:
ENSG00000285132 GRCh38: Ensembl release 89: ENSG00000164733, ENSG00000285132
1516:
1323:
1244:
878:
588:
466:
411:
398:
310:
297:
199:
2634:
2528:
2497:
2456:
2371:
2324:
10.1002/(SICI)1097-0215(19960807)67:4<547::AID-IJC14>3.0.CO;2-4
2291:
2240:
2191:
2165:
2134:
2126:
2098:
1927:
1865:
1814:
1773:
2587:
2546:
2407:
2332:
2305:
van der
Stappen JW, Williams AC, Maciewicz RA, Paraskeva C (August 1996).
2038:
2003:
1962:
1724:
1685:
1626:
1224:
1219:
46:
3174:
2874:
1208:
1027:
1008:
2626:
3003:
2894:
2513:"B cell activation and the establishment of Epstein-Barr virus latency"
1484:
1448:
994:
945:
2818:: CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION
2399:
2363:
1755:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
3471:
3241:
3051:
2983:
2978:
2803:: Crystal Structure of the tetragonal form of human liver cathepsin B
2658:
2438:
2222:
1192:
900:
17:
1318:
Cathepsin B may enhance the activity of other proteases, including
3445:
3026:
1828:
Ha SD, Ham B, Mogridge J, Saftig P, Lin S, Kim SO (January 2010).
1283:
1882:
Yang WE, Ho CC, Yang SF, Lin SH, Yeh KT, Lin CW, Chen MK (2016).
1640:
Chan SJ, San
Segundo B, McCormick MB, Steiner DF (October 1986).
863:
859:
1258:
179:
3214:
2847:
2681:
1337:
Cells may become carcinogenic when cathepsin B is unregulated.
633:
2677:
1344:
2019:
1787:
Lai WF, Chang CH, Tang Y, Bronson R, Tung CH (March 2004).
3210:
844:
proteolysis involved in cellular protein catabolic process
2743:: CATHEPSIN B COMPLEXED WITH DIPEPTIDYL NITRILE INHIBITOR
2063:
Alapati K, Kesanakurti D, Rao JS, Dasari VR (May 2014).
435:
2470:
Mai J, Finley RL, Waisman DM, Sloane BF (April 2000).
3501:
2661:
online database for peptidases and their inhibitors:
600:
3397:
3361:
3330:
3299:
3248:
3157:
3090:
3002:
2971:
2893:
1153:
1112:
1086:
1045:
1556:
1554:
1552:
1535:
1533:
1531:
382:
281:
2344:
2342:
2148:Aggarwal, Neha; Sloane, Bonnie F. (June 2014).
2058:
2056:
1877:
1875:
1699:Cao L, Taggart RT, Berquin IM, Moin K, Fong D,
27:Protein-coding gene in the species Homo sapiens
2511:Hurley EA, Thorley-Lawson DA (December 1988).
2017:Mort JS, Buttle DJ (May 1997). "Cathepsin B".
1561:GRCm38: Ensembl release 89: ENSMUSG00000021939
3226:
2859:
2693:
824:cellular response to thyroid hormone stimulus
8:
3233:
3219:
3211:
2866:
2852:
2844:
2700:
2686:
2678:
1109:
1042:
874:
649:
423:
322:
219:
81:
2670:at the U.S. National Library of Medicine
2577:
2536:
2487:
2446:
2322:
2281:
2271:
2230:
2181:
2088:
1917:
1907:
1855:
1845:
1804:
1763:
1675:
1665:
1435:Learn how and when to remove this message
783:collagen-containing extracellular matrix
723:intracellular membrane-bounded organelle
3549:Extracellular matrix remodeling enzymes
3508:
2715:
2150:"Cathepsin B: Multiple roles in cancer"
1527:
1371:Please improve this article by adding
1330:urokinase plasminogen activator), and
36:
387:
348:
343:
286:
245:
240:
32:Transportation Safety Board of Canada
7:
2517:The Journal of Experimental Medicine
1744:Clinical and Experimental Immunology
814:toll-like receptor signaling pathway
687:cysteine-type endopeptidase activity
2476:The Journal of Biological Chemistry
1834:The Journal of Biological Chemistry
1298:Cathepsin B is synthesized on the
1150:
1083:
1018:
999:
973:
950:
924:
905:
733:intracellular anatomical structure
702:serine-type endopeptidase activity
605:
523:
461:
440:
25:
2421:Pol E, Björk I (September 2001).
2154:Proteomics. Clinical Applications
166:, APPS, CPSB, cathepsin B, RECEUP
3511:
2823:
2808:
2793:
2778:
2763:
2748:
2733:
2718:
1349:
839:regulation of catalytic activity
667:cysteine-type peptidase activity
623:
616:
609:
371:
364:
358:
335:
270:
263:
257:
232:
45:
2311:International Journal of Cancer
1977:"Entrez Gene: CTSB cathepsin B"
804:epithelial cell differentiation
799:regulation of apoptotic process
768:perinuclear region of cytoplasm
1459:Cathepsin B has been shown to
634:More reference expression data
589:More reference expression data
509:olfactory zone of nasal mucosa
1:
2031:10.1016/s1357-2725(96)00152-5
1373:secondary or tertiary sources
356:
255:
30:For the Canadian agency, see
2579:10.1016/0014-5793(91)80318-w
1909:10.1371/journal.pone.0152165
1793:Osteoarthritis and Cartilage
1717:10.1016/0378-1119(94)90750-1
778:ficolin-1-rich granule lumen
3534:Genes on human chromosome 8
1300:rough endoplasmic reticulum
551:subcutaneous adipose tissue
481:right lobe of thyroid gland
477:stromal cell of endometrium
3570:
1806:10.1016/j.joca.2003.11.005
1615:Seminars in Cancer Biology
834:viral entry into host cell
829:collagen catabolic process
567:tunica adventitia of aorta
485:left lobe of thyroid gland
29:
3389:Michaelis–Menten kinetics
2713:
2273:10.1186/s12943-016-0503-9
2081:10.1016/j.scr.2014.02.008
1596:"Mouse PubMed Reference:"
1578:"Human PubMed Reference:"
1302:as a preproenzyme of 339
1223:
1218:
1214:
1207:
1191:
1172:
1157:
1136:
1105:
1090:
1069:
1038:
1025:
1021:
1006:
1002:
993:
980:
976:
957:
953:
944:
931:
927:
912:
908:
899:
884:
877:
873:
857:
652:
648:
631:
608:
599:
586:
535:
526:
473:
464:
434:
426:
422:
405:
392:
355:
334:
325:
321:
304:
291:
254:
231:
222:
218:
173:
170:
160:
153:
148:
89:
84:
67:
62:
57:
53:
44:
39:
3281:Diffusion-limited enzyme
2672:Medical Subject Headings
2489:10.1074/jbc.275.17.12806
2211:Molecular Carcinogenesis
1320:matrix metalloproteinase
1185:Chr 14: 63.36 – 63.38 Mb
849:neutrophil degranulation
1955:10.1089/dna.1991.10.159
1847:10.1074/jbc.M109.065813
1667:10.1073/pnas.83.20.7721
1178:Chr 8: 11.84 – 11.87 Mb
2529:10.1084/jem.168.6.2059
2166:10.1002/prca.201300105
2127:10.1053/hupa.2000.9035
1360:relies excessively on
707:endopeptidase activity
389:14 D1|14 33.24 cM
3374:Eadie–Hofstee diagram
3307:Allosteric regulation
1282:22, consisting of 13
763:extracellular exosome
555:epithelium of stomach
539:stroma of bone marrow
350:Chromosome 14 (mouse)
3384:Lineweaver–Burk plot
2615:Biological Chemistry
1943:DNA and Cell Biology
738:extracellular region
697:proteoglycan binding
559:brown adipose tissue
547:white adipose tissue
505:smooth muscle tissue
248:Chromosome 8 (human)
85:List of PDB id codes
58:Available structures
3170:Cancer procoagulant
2627:10.1515/BC.2003.095
1900:2016PLoSO..1152165Y
1658:1986PNAS...83.7721C
1341:Potential in cancer
1278:gene is located at
1252:cysteine cathepsins
773:extracellular space
493:canal of the cervix
3343:Enzyme superfamily
3276:Enzyme promiscuity
2879:cysteine proteases
2069:Stem Cell Research
1288:housekeeping genes
1248:cysteine proteases
983:ENSMUSG00000021939
792:Biological process
743:endolysosome lumen
716:Cellular component
692:hydrolase activity
677:peptidase activity
660:Molecular function
563:tibiofemoral joint
3499:
3498:
3208:
3207:
2841:
2840:
2400:10.1021/bi980026r
2364:10.1021/bi030119v
1756:10.1111/cei.12357
1445:
1444:
1437:
1419:
1234:
1233:
1230:
1229:
1203:
1202:
1168:
1167:
1147:
1146:
1101:
1100:
1080:
1079:
1034:
1033:
1015:
1014:
989:
988:
970:
969:
940:
939:
921:
920:
869:
868:
644:
643:
640:
639:
595:
594:
582:
581:
575:lactiferous gland
520:
519:
418:
417:
317:
316:
144:
143:
140:
139:
68:Ortholog search:
16:(Redirected from
3561:
3516:
3515:
3507:
3379:Hanes–Woolf plot
3322:Enzyme activator
3317:Enzyme inhibitor
3291:Enzyme catalysis
3235:
3228:
3221:
3212:
3190:3C-like protease
2868:
2861:
2854:
2845:
2827:
2812:
2797:
2782:
2767:
2752:
2737:
2722:
2702:
2695:
2688:
2679:
2646:
2600:
2599:
2581:
2557:
2551:
2550:
2540:
2508:
2502:
2501:
2491:
2482:(17): 12806–12.
2467:
2461:
2460:
2450:
2439:10.1110/ps.11901
2418:
2412:
2411:
2382:
2376:
2375:
2358:(38): 11326–33.
2346:
2337:
2336:
2326:
2302:
2296:
2295:
2285:
2275:
2260:Molecular Cancer
2251:
2245:
2244:
2234:
2223:10.1002/mc.22312
2202:
2196:
2195:
2185:
2160:(5–6): 427–437.
2145:
2139:
2138:
2109:
2103:
2102:
2092:
2060:
2051:
2050:
2014:
2008:
2007:
1998:(14): 1581–643.
1987:
1981:
1980:
1973:
1967:
1966:
1938:
1932:
1931:
1921:
1911:
1879:
1870:
1869:
1859:
1849:
1825:
1819:
1818:
1808:
1784:
1778:
1777:
1767:
1735:
1729:
1728:
1696:
1690:
1689:
1679:
1669:
1637:
1631:
1630:
1610:
1604:
1603:
1592:
1586:
1585:
1574:
1568:
1558:
1547:
1537:
1440:
1433:
1429:
1426:
1420:
1418:
1377:
1353:
1345:
1216:
1215:
1187:
1180:
1163:
1151:
1142:
1110:
1106:RefSeq (protein)
1096:
1084:
1075:
1043:
1019:
1000:
974:
951:
925:
906:
875:
672:collagen binding
650:
636:
627:
620:
613:
606:
591:
531:
529:Top expressed in
524:
469:
467:Top expressed in
462:
441:
424:
414:
401:
390:
375:
368:
362:
351:
339:
323:
313:
300:
289:
274:
267:
261:
250:
236:
220:
214:
212:CTSB - orthologs
165:
158:
135:
82:
76:
55:
54:
49:
37:
21:
3569:
3568:
3564:
3563:
3562:
3560:
3559:
3558:
3524:
3523:
3522:
3510:
3502:
3500:
3495:
3407:Oxidoreductases
3393:
3369:Enzyme kinetics
3357:
3353:List of enzymes
3326:
3295:
3266:Catalytic triad
3244:
3239:
3209:
3204:
3153:
3086:
2998:
2967:
2889:
2872:
2842:
2837:
2834:
2828:
2819:
2813:
2804:
2798:
2789:
2783:
2774:
2768:
2759:
2753:
2744:
2738:
2729:
2723:
2709:
2706:
2654:
2649:
2612:
2608:
2606:Further reading
2603:
2559:
2558:
2554:
2510:
2509:
2505:
2469:
2468:
2464:
2427:Protein Science
2420:
2419:
2415:
2394:(20): 7551–60.
2384:
2383:
2379:
2348:
2347:
2340:
2304:
2303:
2299:
2253:
2252:
2248:
2204:
2203:
2199:
2147:
2146:
2142:
2115:Human Pathology
2111:
2110:
2106:
2062:
2061:
2054:
2016:
2015:
2011:
1992:Protein Profile
1989:
1988:
1984:
1975:
1974:
1970:
1940:
1939:
1935:
1894:(3): e0152165.
1881:
1880:
1873:
1827:
1826:
1822:
1786:
1785:
1781:
1737:
1736:
1732:
1698:
1697:
1693:
1639:
1638:
1634:
1612:
1611:
1607:
1594:
1593:
1589:
1576:
1575:
1571:
1559:
1550:
1538:
1529:
1525:
1513:
1491:Cathepsin B is
1457:
1441:
1430:
1424:
1421:
1378:
1376:
1370:
1366:primary sources
1354:
1343:
1328:serine protease
1316:
1308:Golgi apparatus
1296:
1272:
1267:
1225:View/Edit Mouse
1220:View/Edit Human
1183:
1176:
1173:Location (UCSC)
1159:
1138:
1132:
1128:
1124:
1120:
1116:
1092:
1071:
1065:
1061:
1057:
1053:
1049:
964:ENSG00000285132
962:
960:ENSG00000164733
853:
819:decidualization
787:
711:
682:protein binding
632:
622:
621:
615:
614:
587:
578:
573:
569:
565:
561:
557:
553:
549:
545:
541:
527:
516:
511:
507:
503:
499:
495:
491:
487:
483:
479:
465:
409:
396:
388:
378:
377:
376:
369:
349:
326:Gene location (
308:
295:
287:
277:
276:
275:
268:
246:
223:Gene location (
174:
161:
154:
91:
69:
35:
28:
23:
22:
15:
12:
11:
5:
3567:
3565:
3557:
3556:
3551:
3546:
3541:
3536:
3526:
3525:
3521:
3520:
3497:
3496:
3494:
3493:
3480:
3467:
3454:
3441:
3428:
3415:
3401:
3399:
3395:
3394:
3392:
3391:
3386:
3381:
3376:
3371:
3365:
3363:
3359:
3358:
3356:
3355:
3350:
3345:
3340:
3334:
3332:
3331:Classification
3328:
3327:
3325:
3324:
3319:
3314:
3309:
3303:
3301:
3297:
3296:
3294:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3252:
3250:
3246:
3245:
3240:
3238:
3237:
3230:
3223:
3215:
3206:
3205:
3203:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3161:
3159:
3155:
3154:
3152:
3151:
3146:
3141:
3136:
3131:
3122:
3117:
3112:
3107:
3102:
3096:
3094:
3088:
3087:
3085:
3084:
3079:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3008:
3006:
3000:
2999:
2997:
2996:
2991:
2986:
2981:
2975:
2973:
2969:
2968:
2966:
2965:
2960:
2955:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2899:
2897:
2891:
2890:
2873:
2871:
2870:
2863:
2856:
2848:
2839:
2838:
2836:
2835:
2829:
2822:
2820:
2814:
2807:
2805:
2799:
2792:
2790:
2784:
2777:
2775:
2769:
2762:
2760:
2754:
2747:
2745:
2739:
2732:
2730:
2724:
2717:
2714:
2711:
2710:
2707:
2705:
2704:
2697:
2690:
2682:
2676:
2675:
2665:
2653:
2652:External links
2650:
2648:
2647:
2609:
2607:
2604:
2602:
2601:
2552:
2523:(6): 2059–75.
2503:
2462:
2433:(9): 1729–38.
2413:
2377:
2338:
2297:
2246:
2197:
2140:
2104:
2052:
2009:
1982:
1968:
1933:
1871:
1820:
1779:
1730:
1691:
1652:(20): 7721–5.
1632:
1605:
1587:
1569:
1548:
1526:
1524:
1521:
1520:
1519:
1512:
1509:
1508:
1507:
1502:
1489:
1488:
1482:
1476:
1470:
1456:
1453:
1443:
1442:
1357:
1355:
1348:
1342:
1339:
1315:
1312:
1295:
1292:
1271:
1268:
1266:
1263:
1232:
1231:
1228:
1227:
1222:
1212:
1211:
1205:
1204:
1201:
1200:
1198:
1196:
1189:
1188:
1181:
1174:
1170:
1169:
1166:
1165:
1155:
1154:
1148:
1145:
1144:
1134:
1133:
1107:
1103:
1102:
1099:
1098:
1088:
1087:
1081:
1078:
1077:
1067:
1066:
1040:
1036:
1035:
1032:
1031:
1023:
1022:
1016:
1013:
1012:
1004:
1003:
997:
991:
990:
987:
986:
978:
977:
971:
968:
967:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
891:
886:
882:
881:
871:
870:
867:
866:
855:
854:
852:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
795:
793:
789:
788:
786:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
719:
717:
713:
712:
710:
709:
704:
699:
694:
689:
684:
679:
674:
669:
663:
661:
657:
656:
646:
645:
642:
641:
638:
637:
629:
628:
603:
597:
596:
593:
592:
584:
583:
580:
579:
577:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
533:
532:
521:
518:
517:
515:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
471:
470:
458:
457:
449:
438:
432:
431:
428:RNA expression
420:
419:
416:
415:
407:
403:
402:
394:
391:
386:
380:
379:
370:
363:
357:
353:
352:
347:
341:
340:
332:
331:
319:
318:
315:
314:
306:
302:
301:
293:
290:
285:
279:
278:
269:
262:
256:
252:
251:
244:
238:
237:
229:
228:
216:
215:
172:
168:
167:
159:
151:
150:
146:
145:
142:
141:
138:
137:
87:
86:
78:
77:
66:
60:
59:
51:
50:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3566:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3531:
3529:
3519:
3514:
3509:
3505:
3491:
3487:
3486:
3481:
3478:
3474:
3473:
3468:
3465:
3461:
3460:
3455:
3452:
3448:
3447:
3442:
3439:
3435:
3434:
3429:
3426:
3422:
3421:
3416:
3413:
3409:
3408:
3403:
3402:
3400:
3396:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3366:
3364:
3360:
3354:
3351:
3349:
3348:Enzyme family
3346:
3344:
3341:
3339:
3336:
3335:
3333:
3329:
3323:
3320:
3318:
3315:
3313:
3312:Cooperativity
3310:
3308:
3305:
3304:
3302:
3298:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3271:Oxyanion hole
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3253:
3251:
3247:
3243:
3236:
3231:
3229:
3224:
3222:
3217:
3216:
3213:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3162:
3160:
3156:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3097:
3095:
3093:
3089:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3009:
3007:
3005:
3001:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2976:
2974:
2972:Fruit-derived
2970:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2900:
2898:
2896:
2892:
2887:
2884:
2880:
2876:
2869:
2864:
2862:
2857:
2855:
2850:
2849:
2846:
2832:
2826:
2821:
2817:
2811:
2806:
2802:
2796:
2791:
2787:
2781:
2776:
2772:
2766:
2761:
2757:
2751:
2746:
2742:
2736:
2731:
2727:
2721:
2716:
2712:
2703:
2698:
2696:
2691:
2689:
2684:
2683:
2680:
2673:
2669:
2666:
2664:
2660:
2656:
2655:
2651:
2644:
2640:
2636:
2632:
2628:
2624:
2621:(6): 845–54.
2620:
2616:
2611:
2610:
2605:
2597:
2593:
2589:
2585:
2580:
2575:
2572:(2): 311–15.
2571:
2567:
2563:
2556:
2553:
2548:
2544:
2539:
2534:
2530:
2526:
2522:
2518:
2514:
2507:
2504:
2499:
2495:
2490:
2485:
2481:
2477:
2473:
2466:
2463:
2458:
2454:
2449:
2444:
2440:
2436:
2432:
2428:
2424:
2417:
2414:
2409:
2405:
2401:
2397:
2393:
2389:
2381:
2378:
2373:
2369:
2365:
2361:
2357:
2353:
2345:
2343:
2339:
2334:
2330:
2325:
2320:
2317:(4): 547–54.
2316:
2312:
2308:
2301:
2298:
2293:
2289:
2284:
2279:
2274:
2269:
2265:
2261:
2257:
2250:
2247:
2242:
2238:
2233:
2228:
2224:
2220:
2217:(5): 671–87.
2216:
2212:
2208:
2201:
2198:
2193:
2189:
2184:
2179:
2175:
2171:
2167:
2163:
2159:
2155:
2151:
2144:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2108:
2105:
2100:
2096:
2091:
2086:
2082:
2078:
2075:(3): 716–29.
2074:
2070:
2066:
2059:
2057:
2053:
2048:
2044:
2040:
2036:
2032:
2028:
2025:(5): 715–20.
2024:
2020:
2013:
2010:
2005:
2001:
1997:
1993:
1986:
1983:
1978:
1972:
1969:
1964:
1960:
1956:
1952:
1949:(3): 159–68.
1948:
1944:
1937:
1934:
1929:
1925:
1920:
1915:
1910:
1905:
1901:
1897:
1893:
1889:
1885:
1878:
1876:
1872:
1867:
1863:
1858:
1853:
1848:
1843:
1840:(3): 2120–9.
1839:
1835:
1831:
1824:
1821:
1816:
1812:
1807:
1802:
1799:(3): 239–44.
1798:
1794:
1790:
1783:
1780:
1775:
1771:
1766:
1761:
1757:
1753:
1750:(3): 586–97.
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1718:
1714:
1710:
1706:
1702:
1695:
1692:
1687:
1683:
1678:
1673:
1668:
1663:
1659:
1655:
1651:
1647:
1643:
1636:
1633:
1628:
1624:
1621:(2): 137–52.
1620:
1616:
1609:
1606:
1601:
1597:
1591:
1588:
1583:
1579:
1573:
1570:
1566:
1562:
1557:
1555:
1553:
1549:
1545:
1541:
1536:
1534:
1532:
1528:
1522:
1518:
1515:
1514:
1510:
1506:
1503:
1501:
1498:
1497:
1496:
1494:
1486:
1483:
1480:
1477:
1474:
1471:
1469:
1466:
1465:
1464:
1462:
1454:
1452:
1450:
1439:
1436:
1428:
1425:December 2021
1417:
1414:
1410:
1407:
1403:
1400:
1396:
1393:
1389:
1386: –
1385:
1384:"Cathepsin B"
1381:
1380:Find sources:
1374:
1368:
1367:
1363:
1358:This article
1356:
1352:
1347:
1346:
1340:
1338:
1335:
1333:
1329:
1325:
1321:
1313:
1311:
1309:
1305:
1301:
1293:
1291:
1289:
1285:
1281:
1280:chromosome 8p
1277:
1269:
1264:
1262:
1260:
1257:
1253:
1250:known as the
1249:
1246:
1242:
1239:belongs to a
1238:
1226:
1221:
1217:
1213:
1210:
1206:
1199:
1197:
1194:
1190:
1186:
1182:
1179:
1175:
1171:
1164:
1162:
1156:
1152:
1149:
1143:
1141:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1108:
1104:
1097:
1095:
1089:
1085:
1082:
1076:
1074:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1041:
1039:RefSeq (mRNA)
1037:
1030:
1029:
1024:
1020:
1017:
1011:
1010:
1005:
1001:
998:
996:
992:
985:
984:
979:
975:
972:
966:
965:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
895:
892:
890:
887:
883:
880:
876:
872:
865:
861:
856:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
796:
794:
791:
790:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
753:mitochondrion
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
720:
718:
715:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
664:
662:
659:
658:
655:
654:Gene ontology
651:
647:
635:
630:
626:
619:
612:
607:
604:
602:
598:
590:
585:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
537:
534:
530:
525:
522:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
475:
472:
468:
463:
460:
459:
456:
454:
450:
448:
447:
443:
442:
439:
437:
433:
429:
425:
421:
413:
408:
404:
400:
395:
385:
381:
374:
367:
361:
354:
346:
342:
338:
333:
329:
324:
320:
312:
307:
303:
299:
294:
284:
280:
273:
266:
260:
253:
249:
243:
239:
235:
230:
226:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
169:
164:
157:
152:
147:
136:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
88:
83:
80:
79:
75:
72:
65:
61:
56:
52:
48:
43:
38:
33:
19:
3485:Translocases
3482:
3469:
3456:
3443:
3430:
3420:Transferases
3417:
3404:
3261:Binding site
3099:
2830:
2815:
2800:
2785:
2770:
2755:
2740:
2725:
2618:
2614:
2569:
2566:FEBS Letters
2565:
2555:
2520:
2516:
2506:
2479:
2475:
2465:
2430:
2426:
2416:
2391:
2388:Biochemistry
2387:
2380:
2355:
2352:Biochemistry
2351:
2314:
2310:
2300:
2263:
2259:
2249:
2214:
2210:
2200:
2157:
2153:
2143:
2121:(8): 931–7.
2118:
2114:
2107:
2072:
2068:
2022:
2018:
2012:
1995:
1991:
1985:
1971:
1946:
1942:
1936:
1891:
1887:
1837:
1833:
1823:
1796:
1792:
1782:
1747:
1743:
1733:
1711:(2): 163–9.
1708:
1704:
1694:
1649:
1645:
1635:
1618:
1614:
1608:
1599:
1590:
1581:
1572:
1490:
1458:
1455:Interactions
1446:
1431:
1422:
1412:
1405:
1398:
1391:
1379:
1359:
1336:
1317:
1297:
1275:
1273:
1255:
1236:
1235:
1158:
1137:
1114:NP_001304166
1091:
1073:NM_001317237
1070:
1026:
1007:
981:
958:
932:
913:
893:
888:
451:
444:
171:External IDs
90:
3256:Active site
3200:Gingipain K
3195:Gingipain R
3165:Clostripain
2708:PDB gallery
2668:Cathepsin+B
1500:Nitroxoline
1332:cathepsin D
1304:amino acids
1237:Cathepsin B
809:proteolysis
497:gallbladder
410:63,383,372
397:63,359,911
309:11,869,448
296:11,842,524
149:Identifiers
3554:Cathepsins
3528:Categories
3459:Isomerases
3433:Hydrolases
3300:Regulation
3180:Autophagin
2994:Actinidain
2963:Caspase 14
2958:Caspase 13
2953:Caspase 12
2948:Caspase 10
1567:, May 2017
1546:, May 2017
1523:References
1517:Cathepsins
1395:newspapers
1362:references
728:melanosome
501:ectocervix
455:(ortholog)
192:HomoloGene
3544:Proteases
3539:EC 3.4.22
3338:EC number
3185:Cruzipain
3092:Cathepsin
2989:Bromelain
2943:Caspase 9
2938:Caspase 8
2933:Caspase 7
2928:Caspase 6
2923:Caspase 5
2918:Caspase 4
2913:Caspase 3
2908:Caspase 2
2903:Caspase 1
2875:Proteases
2174:1862-8346
1701:Sloane BF
1493:inhibited
1324:urokinase
1265:Structure
1245:lysosomal
1161:NP_031824
1140:NP_680093
1130:NP_680092
1126:NP_680091
1122:NP_680090
1118:NP_001899
1094:NM_007798
1063:NM_147783
1059:NM_147782
1055:NM_147781
1051:NM_147780
1047:NM_001908
879:Orthologs
748:nucleolus
200:GeneCards
3362:Kinetics
3286:Cofactor
3249:Activity
3175:Separase
2643:27472370
2635:12887051
2596:46523390
2498:10777578
2457:11514663
2372:14503883
2292:26896959
2241:25808857
2192:24677670
2135:10987253
2099:24699410
2047:37767552
1928:27031837
1888:PLOS ONE
1866:19858192
1815:14972341
1774:24749816
1563:–
1542:–
1511:See also
1461:interact
1314:Function
1209:Wikidata
858:Sources:
758:lysosome
543:calvaria
513:monocyte
489:appendix
3518:Biology
3472:Ligases
3242:Enzymes
3004:Calpain
2895:Caspase
2663:C01.060
2588:2013328
2547:2848918
2538:2189139
2448:2253190
2408:9585570
2333:8759615
2283:4761221
2232:4832390
2183:4205946
2090:4061617
2039:9251238
2004:8771190
1963:2012677
1919:4816521
1896:Bibcode
1857:2804368
1765:4137842
1725:8112600
1686:3463996
1654:Bibcode
1627:2103490
1565:Ensembl
1544:Ensembl
1485:S100A10
1449:cancers
1409:scholar
1294:Protein
995:UniProt
946:Ensembl
885:Species
864:QuickGO
571:decidua
430:pattern
156:Aliases
3504:Portal
3446:Lyases
3082:CAPNS2
3077:CAPNS1
3072:CAPN14
3067:CAPN13
3062:CAPN12
3057:CAPN11
3052:CAPN10
2984:Ficain
2979:Papain
2886:3.4.22
2674:(MeSH)
2659:MEROPS
2641:
2633:
2594:
2586:
2545:
2535:
2496:
2455:
2445:
2406:
2370:
2331:
2290:
2280:
2266:: 17.
2239:
2229:
2190:
2180:
2172:
2133:
2097:
2087:
2045:
2037:
2002:
1961:
1926:
1916:
1864:
1854:
1813:
1772:
1762:
1723:
1684:
1677:386793
1674:
1625:
1505:CA-074
1463:with:
1411:
1404:
1397:
1390:
1382:
1241:family
1195:search
1193:PubMed
1028:P10605
1009:P07858
901:Entrez
601:BioGPS
288:8p23.1
180:116810
3398:Types
3158:Other
3047:CAPN9
3042:CAPN8
3037:CAPN7
3032:CAPN6
3027:CAPN5
3022:CAPN3
3017:CAPN2
3012:CAPN1
2639:S2CID
2592:S2CID
2043:S2CID
1481:, and
1416:JSTOR
1402:books
1284:exons
934:13030
894:Mouse
889:Human
860:Amigo
453:Mouse
446:Human
393:Start
328:Mouse
292:Start
225:Human
196:37550
188:88561
3490:list
3483:EC7
3477:list
3470:EC6
3464:list
3457:EC5
3451:list
3444:EC4
3438:list
3431:EC3
3425:list
3418:EC2
3412:list
3405:EC1
2831:3pbh
2816:2pbh
2801:2ipp
2786:1sp4
2771:1pbh
2756:1huc
2741:1gmy
2726:1csb
2657:The
2631:PMID
2584:PMID
2543:PMID
2494:PMID
2453:PMID
2404:PMID
2386:L".
2368:PMID
2329:PMID
2288:PMID
2237:PMID
2188:PMID
2170:ISSN
2131:PMID
2095:PMID
2035:PMID
2000:PMID
1959:PMID
1924:PMID
1862:PMID
1811:PMID
1770:PMID
1721:PMID
1705:Gene
1682:PMID
1623:PMID
1495:by:
1479:CSTB
1473:CSTA
1468:CTSD
1388:news
1276:CTSB
1274:The
1270:Gene
1259:gene
1256:CTSB
915:1508
436:Bgee
384:Band
345:Chr.
283:Band
242:Chr.
204:CTSB
176:OMIM
163:CTSB
133:3K9M
129:3CBK
125:3CBJ
121:3AI8
117:2PBH
113:2IPP
109:1PBH
105:1HUC
101:1GMY
97:1CSB
93:3PBH
74:RCSB
71:PDBe
40:CTSB
18:CTSB
2623:doi
2619:384
2574:doi
2570:280
2533:PMC
2525:doi
2521:168
2484:doi
2480:275
2443:PMC
2435:doi
2396:doi
2360:doi
2319:doi
2278:PMC
2268:doi
2227:PMC
2219:doi
2178:PMC
2162:doi
2123:doi
2085:PMC
2077:doi
2027:doi
1951:doi
1914:PMC
1904:doi
1852:PMC
1842:doi
1838:285
1801:doi
1760:PMC
1752:doi
1748:177
1713:doi
1709:139
1672:PMC
1662:doi
1364:to
1243:of
406:End
305:End
208:OMA
184:MGI
64:PDB
3530::
3129:L2
3125:L1
2883:EC
2877::
2637:.
2629:.
2617:.
2590:.
2582:.
2568:.
2564:.
2541:.
2531:.
2519:.
2515:.
2492:.
2478:.
2474:.
2451:.
2441:.
2431:10
2429:.
2425:.
2402:.
2392:37
2390:.
2366:.
2356:42
2354:.
2341:^
2327:.
2315:67
2313:.
2309:.
2286:.
2276:.
2264:15
2262:.
2258:.
2235:.
2225:.
2215:55
2213:.
2209:.
2186:.
2176:.
2168:.
2156:.
2152:.
2129:.
2119:31
2117:.
2093:.
2083:.
2073:12
2071:.
2067:.
2055:^
2041:.
2033:.
2023:29
2021:.
1994:.
1957:.
1947:10
1945:.
1922:.
1912:.
1902:.
1892:11
1890:.
1886:.
1874:^
1860:.
1850:.
1836:.
1832:.
1809:.
1797:12
1795:.
1791:.
1768:.
1758:.
1746:.
1742:.
1719:.
1707:.
1680:.
1670:.
1660:.
1650:83
1648:.
1644:.
1617:.
1598:.
1580:.
1551:^
1530:^
1375:.
1322:,
862:/
412:bp
399:bp
311:bp
298:bp
206:;
202::
198:;
194::
190:;
186::
182:;
178::
131:,
127:,
123:,
119:,
115:,
111:,
107:,
103:,
99:,
95:,
3506::
3492:)
3488:(
3479:)
3475:(
3466:)
3462:(
3453:)
3449:(
3440:)
3436:(
3427:)
3423:(
3414:)
3410:(
3234:e
3227:t
3220:v
3149:Z
3144:W
3139:S
3134:O
3127:/
3120:K
3115:H
3110:F
3105:C
3100:B
2888:)
2881:(
2867:e
2860:t
2853:v
2701:e
2694:t
2687:v
2645:.
2625::
2598:.
2576::
2549:.
2527::
2500:.
2486::
2459:.
2437::
2410:.
2398::
2374:.
2362::
2335:.
2321::
2294:.
2270::
2243:.
2221::
2194:.
2164::
2158:8
2137:.
2125::
2101:.
2079::
2049:.
2029::
2006:.
1996:2
1979:.
1965:.
1953::
1930:.
1906::
1898::
1868:.
1844::
1817:.
1803::
1776:.
1754::
1727:.
1715::
1688:.
1664::
1656::
1629:.
1619:1
1602:.
1584:.
1487:.
1475:,
1438:)
1432:(
1427:)
1423:(
1413:·
1406:·
1399:·
1392:·
1369:.
1326:(
330:)
227:)
210::
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.