316:
293:
190:
215:
2823:
2808:
2793:
567:
581:
574:
322:
221:
31:
3704:
2320:
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den
Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, Rasmussen S (June
57:
1515:, a hereditary disorder in which individuals develop multiple skin tumors. The CYLD cutaneous syndrome includes three somewhat different forms of the disease: the multiple familial trichoepithelioma-type, Brooke–Spiegler syndrome-type, and familial cylindromatosis-type.
2138:
Biggs PJ, Wooster R, Ford D, Chapman P, Mangion J, Quirk Y, Easton DF, Burn J, Stratton MR (December 1995). "Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene".
1511:, i.e. a gene that regulates cell growth and when inactivated by a mutation leads to uncontrolled cell growth and the formation of tumors. Inactivating mutations in this gene occur in essentially all cases of the
2205:
Biggs PJ, Chapman P, Lakhani SR, Burn J, Stratton MR (March 1996). "The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas".
2401:
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G (August 2003). "CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members".
2863:
2511:
Kovalenko A, Chable-Bessia C, Cantarella G, Israël A, Wallach D, Courtois G (August 2003). "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination".
2822:
2807:
2358:
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000).
2070:
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones".
2792:
3116:
2227:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
329:
228:
2258:"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
1801:
Weisbrich A, Honnappa S, Jaussi R, Okhrimenko O, Frey D, Jelesarov I, Akhmanova A, Steinmetz MO (October 2007). "Structure-function relationship of CAP-Gly domains".
2856:
2360:"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"
2456:
Brummelkamp TR, Nijman SM, Dirac AM, Bernards R (August 2003). "Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB".
54:
1044:
1025:
151:
2681:"NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway"
3778:
2849:
2176:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
3461:
1473:
from certain proteins and thereby regulates these proteins' activities. CYLD protein removes ubiquitin from proteins involved in regulating the
3749:
3768:
2772:
1636:
1618:
1738:
Arruda AP, Cardoso-Dos-Santos AC, Mariath LM, Feira MF, Kowalski TW, Bezerra KR, da Silva LA, Ribeiro EM, Schuler-Faccini L (July 2020).
2291:
Thomson SA, Rasmussen SA, Zhang J, Wallace MR (1999). "A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16".
1520:
315:
3679:
1348:
2732:
1355:
292:
2603:"The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor"
1457:
gene in known to code for a cytoplasmic protein, termed CYLD lysine 63 deubiquitinase (here termed CYLD protein), which has three
1787:
1461:-associated protein-glycine-conserved (CAP-GLY) domains (areas or the protein controlling critical functions). CYLD protein is a
2872:
1605:
1584:
3072:
1556:
214:
189:
1601:
2008:
Davies HR, Hodgson K, Schwalbe E, Coxhead J, Sinclair N, Zou X, Cockell S, Husain A, Nik-Zainal S, Rajan N (October 2019).
2738:
2256:
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998).
1580:
3285:
131:
3230:
328:
227:
3742:
2109:
Lian F, Cockerell CJ (2006). "Cutaneous appendage tumors: familial cylindromatosis and associated tumors update".
2765:
2646:"Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma"
321:
220:
1907:"CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers"
3170:
1528:
1089:
139:
3495:
1512:
1482:
1462:
1070:
3667:
3536:
2079:
3735:
2917:
1508:
1478:
203:
1681:"Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog"
2758:
2520:
2465:
2410:
2021:
1692:
1447:
1298:
1294:
1654:
118:
2880:
2744:
2084:
1327:
1323:
1319:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1240:
1236:
1228:
1224:
1200:
1196:
1192:
1188:
1163:
1159:
2644:
Zhang XJ, Liang YH, He PP, Yang S, Wang HY, Chen JJ, Yuan WT, Xu SJ, Cui Y, Huang W (March 2004).
3773:
3526:
2894:
2544:
2499:
2444:
2346:
2164:
1826:
163:
1331:
1232:
1204:
1167:
3196:
2712:
2667:
2632:
2589:
2536:
2491:
2436:
2389:
2338:
2308:
2279:
2244:
2215:
2193:
2156:
2126:
2097:
2047:
1990:
1936:
1882:
1818:
1769:
1720:
1679:
Hadweh P, Chaitoglou I, Gravato-Nobre MJ, Ligoxygakis P, Mosialos G, Hatzivassiliou E (2018).
1536:
1496:
pathways; these pathways normally act to regulate hair formation, cell growth, cell survival,
111:
47:
3719:
2831:: Solution structure of the 2nd CAP-Gly domain in human cylindromatosis tumor suppressor CYLD
2816:: Solution structure of the 1st CAP-Gly domain in human cylindromatosis tumor suppressor CYLD
3456:
3415:
3410:
3385:
3375:
3370:
3360:
3160:
2801:: Solution structure of the CAP-GLY domain from human cylindromatosis tomour-suppressor CYLD
2702:
2692:
2657:
2622:
2614:
2579:
2569:
2528:
2481:
2473:
2426:
2418:
2379:
2371:
2330:
2300:
2269:
2236:
2185:
2148:
2118:
2089:
2037:
2029:
1980:
1970:
1926:
1918:
1872:
1862:
1810:
1759:
1751:
1710:
1700:
1524:
1431:
566:
408:
339:
283:
238:
3431:
3365:
3662:
2885:
580:
573:
383:
159:
122:, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD lysine 63 deubiquitinase
2010:"Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome"
2524:
2469:
2414:
2025:
1696:
3209:
3204:
2627:
2602:
2042:
2009:
1985:
1958:
1931:
1906:
1877:
1850:
1764:
1739:
1715:
1680:
1544:
1540:
1493:
2384:
2359:
2240:
1740:"A large family with CYLD cutaneous syndrome: medical genetics at the community level"
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
30:
3762:
3715:
2707:
2679:
Jono H, Lim JH, Chen LF, Xu H, Trompouki E, Pan ZK, Mosialos G, Li JD (August 2004).
2662:
2645:
2601:
Regamey A, Hohl D, Liu JW, Roger T, Kogerman P, Toftgard R, Huber M (December 2003).
2574:
2557:
2431:
2189:
1532:
1435:
609:
2350:
2168:
1830:
143:
3565:
3547:
2548:
2503:
2448:
1548:
1497:
1458:
1439:
1419:
401:
180:
1922:
2841:
1705:
167:
3641:
2321:
2000). "Identification of the familial cylindromatosis tumour-suppressor gene".
1641:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1623:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1552:
2556:
Hu G, Onder M, Gill M, Aksakal B, Oztas M, Gürer MA, Celebi JT (October 2003).
2122:
2033:
1975:
1755:
484:
3471:
2899:
300:
197:
147:
2584:
2558:"A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome"
2274:
2257:
1422:
ancient gene found to be present as far back on the evolutionary scale as in
3219:
3165:
2093:
1470:
1427:
989:
544:
422:
367:
354:
266:
253:
155:
2716:
2697:
2680:
2671:
2636:
2593:
2540:
2495:
2440:
2393:
2342:
2312:
2283:
2130:
2101:
2051:
1994:
1940:
1886:
1822:
1773:
1724:
2304:
2248:
2219:
2197:
2160:
1395:
1390:
3499:
3132:
3124:
2618:
1867:
1486:
1474:
1466:
1443:
1379:
1134:
1115:
2532:
2477:
2422:
3250:
3137:
3097:
3028:
3023:
3018:
3013:
3008:
2963:
2152:
1423:
1101:
1056:
2486:
2375:
840:
nucleotide-binding oligomerization domain containing signaling pathway
88:
84:
80:
76:
3466:
3441:
3436:
3426:
3390:
3380:
3355:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3270:
3255:
3102:
3067:
3052:
3047:
3042:
3003:
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2958:
2953:
2948:
2943:
2938:
1814:
1363:
1011:
3703:
3657:
3647:
3637:
3622:
3604:
3599:
3594:
3589:
3521:
3481:
3446:
3420:
3405:
3400:
3395:
3350:
3345:
3300:
3295:
3290:
3260:
3245:
3142:
3111:
3092:
3087:
3082:
3077:
3062:
3057:
3037:
2933:
2926:
2922:
2912:
2907:
2334:
865:
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
974:
970:
3711:
3672:
3652:
3632:
3627:
3577:
3560:
3516:
3504:
3486:
3476:
3275:
3265:
3240:
3235:
3180:
3175:
1415:
135:
2845:
2754:
589:
2750:
1490:
855:
regulation of tumor necrosis factor-mediated signaling pathway
835:
negative regulation of NF-kappaB transcription factor activity
820:
positive regulation of extrinsic apoptotic signaling pathway
1788:"Entrez Gene: CYLD cylindromatosis (turban tumor syndrome)"
719:
extrinsic component of cytoplasmic side of plasma membrane
900:
positive regulation of T cell receptor signaling pathway
391:
3723:
1851:"Genetic Testing in CYLD Cutaneous Syndrome: An Update"
1905:
Cui Z, Kang H, Grandis JR, Johnson DE (January 2021).
845:
negative regulation of canonical Wnt signaling pathway
556:
915:
ripoptosome assembly involved in necroptotic process
3615:
3546:
3535:
3218:
3195:
3153:
2893:
2879:
1312:
1223:
1181:
1152:
830:
negative regulation of type I interferon production
795:
regulation of microtubule cytoskeleton organization
785:
regulation of intrinsic apoptotic signaling pathway
1597:
1595:
1593:
1576:
1574:
1572:
338:
237:
1957:Lei H, Wang J, Hu J, Zhu Q, Wu Y (August 2021).
1959:"Deubiquitinases in hematological malignancies"
1952:
1950:
1900:
1898:
1896:
1844:
1842:
1840:
16:Protein-coding gene in the species Homo sapiens
1602:GRCm38: Ensembl release 89: ENSMUSG00000036712
940:negative regulation of NIK/NF-kappaB signaling
3743:
2857:
2766:
890:positive regulation of T cell differentiation
885:negative regulation of T cell differentiation
790:ubiquitin-dependent protein catabolic process
8:
1849:Nagy N, Dubois A, Szell M, Rajan N (2021).
1581:GRCh38: Ensembl release 89: ENSG00000083799
925:positive regulation of protein localization
3750:
3736:
3543:
2890:
2864:
2850:
2842:
2773:
2759:
2751:
1220:
985:
605:
379:
278:
175:
65:
2706:
2696:
2661:
2626:
2583:
2573:
2485:
2430:
2383:
2273:
2083:
2041:
1984:
1974:
1930:
1876:
1866:
1803:Nature Structural & Molecular Biology
1763:
1714:
1704:
1442:(i.e. direct the production of) multiple
2650:The Journal of Investigative Dermatology
2562:The Journal of Investigative Dermatology
1519:gene mutations are also associated with
2788:
1568:
1557:human papillomavirus-associated cancers
950:negative regulation of p38MAPK cascade
673:Lys48-specific deubiquitinase activity
668:Lys63-specific deubiquitinase activity
20:
1500:responses, and/or tumor development.
1426:. In humans, this gene is located in
343:
304:
299:
242:
201:
196:
7:
3700:
3698:
2607:The Journal of Experimental Medicine
1855:The Application of Clinical Genetics
880:regulation of B cell differentiation
2685:The Journal of Biological Chemistry
1521:T-Cell Acute Lymphoblastic Leukemia
955:regulation of inflammatory response
910:protein K48-linked deubiquitination
810:protein K63-linked deubiquitination
3722:. You can help Knowledge (XXG) by
3680:Prokaryotic ubiquitin-like protein
1309:
1178:
1149:
1125:
1106:
1080:
1061:
1035:
1016:
945:negative regulation of JNK cascade
678:structural constituent of ribosome
561:
479:
417:
396:
14:
960:regulation of necroptotic process
433:lateral nuclear group of thalamus
3702:
2821:
2806:
2791:
2663:10.1111/j.0022-202X.2004.22321.x
2575:10.1046/j.1523-1747.2003.12514.x
815:regulation of mitotic cell cycle
623:cysteine-type peptidase activity
579:
572:
565:
327:
320:
314:
291:
226:
219:
213:
188:
29:
930:protein linear deubiquitination
744:perinuclear region of cytoplasm
3779:Human chromosome 16 gene stubs
3210:Mitochondrial targeting signal
2873:Posttranslational modification
895:homeostasis of number of cells
648:thiol-dependent deubiquitinase
590:More reference expression data
545:More reference expression data
1:
2241:10.1016/S0378-1119(97)00411-3
1923:10.1158/1541-7786.MCR-20-0565
1744:Journal of Community Genetics
1409:CYLD lysine 63 deubiquitinase
920:regulation of cilium assembly
870:regulation of protein binding
734:microtubule organizing center
312:
211:
3769:Genes on human chromosome 16
3286:Ubiquitin-conjugating enzyme
2190:10.1016/0378-1119(94)90802-8
1706:10.1371/journal.pone.0191864
3574:E2 SUMO-conjugating enzyme
3231:Ubiquitin-activating enzyme
653:proline-rich region binding
3795:
3697:
3557:E1 SUMO-activating enzyme
2743:gene details page in the
2123:10.1016/j.yadr.2005.06.005
2034:10.1038/s41467-019-12746-w
1976:10.1186/s40364-021-00320-w
1756:10.1007/s12687-019-00447-2
2786:
2708:21.11116/0000-0007-9489-7
2432:21.11116/0000-0007-948F-1
1911:Molecular Cancer Research
1637:"Mouse PubMed Reference:"
1619:"Human PubMed Reference:"
1394:
1389:
1385:
1378:
1362:
1343:
1316:
1247:
1216:
1185:
1156:
1145:
1132:
1128:
1113:
1109:
1100:
1087:
1083:
1068:
1064:
1055:
1042:
1038:
1023:
1019:
1010:
995:
988:
984:
968:
608:
604:
587:
564:
555:
542:
531:medial geniculate nucleus
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
3171:Survival of motor neuron
1655:"Symbol report for CYLD"
1529:hepatocellular carcinoma
1507:gene is classified as a
860:protein deubiquitination
523:anterior amygdaloid area
449:external globus pallidus
3537:Ubiquitin-like proteins
3496:Deubiquitinating enzyme
2111:Advances in Dermatology
1513:CYLD cutaneous syndrome
1463:deubiquitinating enzyme
1446:through the process of
1356:Chr 8: 89.42 – 89.48 Mb
1349:Chr 16: 50.74 – 50.8 Mb
935:cytoplasmic translation
749:cytoplasmic microtubule
2698:10.1074/jbc.M406638200
2275:10.1093/dnares/5.6.355
1411:gene, also termed the
875:innate immune response
663:protein kinase binding
515:mesenteric lymph nodes
511:lateral septal nucleus
2305:10.1007/s004399900077
2094:10.1093/dnares/9.3.99
2014:Nature Communications
1509:tumor suppressor gene
850:immune system process
800:Wnt signaling pathway
457:middle temporal gyrus
204:Chromosome 16 (human)
2737:genome location and
2619:10.1084/jem.20031187
1868:10.2147/TACG.S288274
1448:alternative splicing
519:ventromedial nucleus
306:Chromosome 8 (mouse)
69:List of PDB id codes
42:Available structures
2895:Heat shock proteins
2745:UCSC Genome Browser
2533:10.1038/nature01802
2525:2003Natur.424..801K
2478:10.1038/nature01811
2470:2003Natur.424..797B
2423:10.1038/nature01803
2415:2003Natur.424..793T
2026:2019NatCo..10.4717D
1697:2018PLoSO..1391864H
3710:This article on a
2153:10.1038/ng1295-441
1963:Biomarker Research
1659:www.genenames.org/
1090:ENSMUSG00000036712
778:Biological process
764:ciliary basal body
687:Cellular component
658:hydrolase activity
638:peptidase activity
616:Molecular function
503:olfactory tubercle
3731:
3730:
3692:
3691:
3688:
3687:
3197:Protein targeting
3191:
3190:
2839:
2838:
2585:20.500.12648/7847
2464:(6950): 797–801.
2376:10.1101/gr.140200
1537:pancreatic cancer
1432:long (or "q") arm
1405:
1404:
1401:
1400:
1374:
1373:
1339:
1338:
1306:
1305:
1212:
1211:
1175:
1174:
1141:
1140:
1122:
1121:
1096:
1095:
1077:
1076:
1051:
1050:
1032:
1031:
980:
979:
633:metal ion binding
600:
599:
596:
595:
551:
550:
538:
537:
507:nucleus accumbens
476:
475:
374:
373:
273:
272:
100:
99:
96:
95:
52:Ortholog search:
3786:
3752:
3745:
3738:
3706:
3699:
3544:
3457:Ubiquitin ligase
3223:(ubiquitylation)
3161:Alpha crystallin
2891:
2866:
2859:
2852:
2843:
2825:
2810:
2795:
2775:
2768:
2761:
2752:
2720:
2710:
2700:
2675:
2665:
2640:
2630:
2597:
2587:
2577:
2552:
2507:
2489:
2452:
2434:
2397:
2387:
2354:
2316:
2287:
2277:
2252:
2223:
2201:
2172:
2134:
2105:
2087:
2056:
2055:
2045:
2005:
1999:
1998:
1988:
1978:
1954:
1945:
1944:
1934:
1902:
1891:
1890:
1880:
1870:
1846:
1835:
1834:
1815:10.1038/nsmb1291
1798:
1792:
1791:
1784:
1778:
1777:
1767:
1735:
1729:
1728:
1718:
1708:
1676:
1670:
1669:
1667:
1665:
1651:
1645:
1644:
1633:
1627:
1626:
1615:
1609:
1599:
1588:
1578:
1525:multiple myeloma
1438:and is known to
1387:
1386:
1358:
1351:
1334:
1310:
1301:
1221:
1217:RefSeq (protein)
1207:
1179:
1170:
1150:
1126:
1107:
1081:
1062:
1036:
1017:
986:
628:zinc ion binding
606:
592:
583:
576:
569:
562:
547:
487:
485:Top expressed in
480:
445:cartilage tissue
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
168:CYLD - orthologs
121:
114:
91:
66:
60:
39:
38:
33:
21:
3794:
3793:
3789:
3788:
3787:
3785:
3784:
3783:
3759:
3758:
3757:
3756:
3695:
3693:
3684:
3611:
3586:E3 SUMO ligase
3550:
3539:
3531:
3222:
3214:
3187:
3149:
3128:
3120:
2898:
2886:protein folding
2884:
2875:
2870:
2840:
2835:
2832:
2826:
2817:
2811:
2802:
2796:
2782:
2779:
2728:
2723:
2691:(35): 36171–4.
2678:
2643:
2613:(12): 1959–64.
2600:
2555:
2519:(6950): 801–5.
2510:
2455:
2409:(6950): 793–6.
2400:
2370:(10): 1546–60.
2364:Genome Research
2357:
2323:Nature Genetics
2319:
2290:
2255:
2235:(1–2): 149–56.
2226:
2204:
2175:
2141:Nature Genetics
2137:
2108:
2069:
2065:
2063:Further reading
2060:
2059:
2007:
2006:
2002:
1956:
1955:
1948:
1904:
1903:
1894:
1848:
1847:
1838:
1800:
1799:
1795:
1786:
1785:
1781:
1737:
1736:
1732:
1691:(2): e0191864.
1678:
1677:
1673:
1663:
1661:
1653:
1652:
1648:
1635:
1634:
1630:
1617:
1616:
1612:
1600:
1591:
1579:
1570:
1565:
1396:View/Edit Mouse
1391:View/Edit Human
1354:
1347:
1344:Location (UCSC)
1330:
1326:
1322:
1318:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1243:
1239:
1235:
1231:
1227:
1203:
1199:
1195:
1191:
1187:
1166:
1162:
1158:
1071:ENSG00000083799
964:
773:
724:plasma membrane
709:cell projection
682:
643:protein binding
588:
578:
577:
571:
570:
543:
534:
529:
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
463:
461:pars reticulata
459:
455:
451:
447:
443:
439:
437:Achilles tendon
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
75:
53:
17:
12:
11:
5:
3792:
3790:
3782:
3781:
3776:
3771:
3761:
3760:
3755:
3754:
3747:
3740:
3732:
3729:
3728:
3707:
3690:
3689:
3686:
3685:
3683:
3682:
3676:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3635:
3630:
3625:
3619:
3617:
3613:
3612:
3610:
3609:
3608:
3607:
3602:
3597:
3592:
3583:
3582:
3581:
3580:
3571:
3570:
3569:
3568:
3563:
3554:
3552:
3541:
3533:
3532:
3530:
3529:
3524:
3519:
3513:
3512:
3507:
3502:
3492:
3491:
3490:
3489:
3484:
3479:
3474:
3469:
3464:
3452:
3451:
3450:
3449:
3444:
3439:
3434:
3429:
3424:
3418:
3413:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3281:
3280:
3279:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3226:
3224:
3216:
3215:
3213:
3212:
3207:
3205:Signal peptide
3201:
3199:
3193:
3192:
3189:
3188:
3186:
3185:
3184:
3183:
3178:
3168:
3163:
3157:
3155:
3151:
3150:
3148:
3147:
3146:
3145:
3140:
3135:
3130:
3126:
3122:
3118:
3108:
3107:
3106:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3034:
3033:
3032:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2930:
2929:
2920:
2915:
2910:
2904:
2902:
2888:
2877:
2876:
2871:
2869:
2868:
2861:
2854:
2846:
2837:
2836:
2834:
2833:
2827:
2820:
2818:
2812:
2805:
2803:
2797:
2790:
2787:
2784:
2783:
2780:
2778:
2777:
2770:
2763:
2755:
2749:
2748:
2727:
2726:External links
2724:
2722:
2721:
2676:
2641:
2598:
2553:
2508:
2453:
2398:
2355:
2317:
2299:(1–2): 171–3.
2293:Human Genetics
2288:
2253:
2224:
2202:
2184:(1–2): 171–4.
2173:
2135:
2106:
2085:10.1.1.500.923
2066:
2064:
2061:
2058:
2057:
2000:
1946:
1892:
1836:
1809:(10): 959–67.
1793:
1779:
1750:(3): 279–284.
1730:
1671:
1646:
1628:
1610:
1589:
1567:
1566:
1564:
1561:
1545:stomach cancer
1541:uterine cancer
1494:cell signaling
1403:
1402:
1399:
1398:
1393:
1383:
1382:
1376:
1375:
1372:
1371:
1369:
1367:
1360:
1359:
1352:
1345:
1341:
1340:
1337:
1336:
1314:
1313:
1307:
1304:
1303:
1299:NP_001035877.1
1295:NP_001035814.1
1245:
1244:
1218:
1214:
1213:
1210:
1209:
1183:
1182:
1176:
1173:
1172:
1154:
1153:
1147:
1143:
1142:
1139:
1138:
1130:
1129:
1123:
1120:
1119:
1111:
1110:
1104:
1098:
1097:
1094:
1093:
1085:
1084:
1078:
1075:
1074:
1066:
1065:
1059:
1053:
1052:
1049:
1048:
1040:
1039:
1033:
1030:
1029:
1021:
1020:
1014:
1008:
1007:
1002:
997:
993:
992:
982:
981:
978:
977:
966:
965:
963:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
781:
779:
775:
774:
772:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
602:
601:
598:
597:
594:
593:
585:
584:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3791:
3780:
3777:
3775:
3772:
3770:
3767:
3766:
3764:
3753:
3748:
3746:
3741:
3739:
3734:
3733:
3727:
3725:
3721:
3717:
3716:chromosome 16
3713:
3708:
3705:
3701:
3696:
3681:
3678:
3677:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3643:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3620:
3618:
3614:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3587:
3585:
3584:
3579:
3576:
3575:
3573:
3572:
3567:
3564:
3562:
3559:
3558:
3556:
3555:
3553:
3551:(SUMOylation)
3549:
3545:
3542:
3538:
3534:
3528:
3525:
3523:
3520:
3518:
3515:
3514:
3511:
3508:
3506:
3503:
3501:
3497:
3494:
3493:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3459:
3458:
3454:
3453:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3288:
3287:
3283:
3282:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3233:
3232:
3228:
3227:
3225:
3221:
3217:
3211:
3208:
3206:
3203:
3202:
3200:
3198:
3194:
3182:
3179:
3177:
3174:
3173:
3172:
3169:
3167:
3164:
3162:
3159:
3158:
3156:
3152:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3123:
3121:
3115:
3114:
3113:
3110:
3109:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3040:
3039:
3036:
3035:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2936:
2935:
2932:
2931:
2928:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2905:
2903:
2901:
2896:
2892:
2889:
2887:
2882:
2878:
2874:
2867:
2862:
2860:
2855:
2853:
2848:
2847:
2844:
2830:
2824:
2819:
2815:
2809:
2804:
2800:
2794:
2789:
2785:
2776:
2771:
2769:
2764:
2762:
2757:
2756:
2753:
2746:
2742:
2741:
2736:
2735:
2730:
2729:
2725:
2718:
2714:
2709:
2704:
2699:
2694:
2690:
2686:
2682:
2677:
2673:
2669:
2664:
2659:
2656:(3): 658–64.
2655:
2651:
2647:
2642:
2638:
2634:
2629:
2624:
2620:
2616:
2612:
2608:
2604:
2599:
2595:
2591:
2586:
2581:
2576:
2571:
2567:
2563:
2559:
2554:
2550:
2546:
2542:
2538:
2534:
2530:
2526:
2522:
2518:
2514:
2509:
2505:
2501:
2497:
2493:
2488:
2483:
2479:
2475:
2471:
2467:
2463:
2459:
2454:
2450:
2446:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2404:
2399:
2395:
2391:
2386:
2381:
2377:
2373:
2369:
2365:
2361:
2356:
2352:
2348:
2344:
2340:
2336:
2335:10.1038/76006
2332:
2328:
2324:
2318:
2314:
2310:
2306:
2302:
2298:
2294:
2289:
2285:
2281:
2276:
2271:
2268:(6): 355–64.
2267:
2263:
2259:
2254:
2250:
2246:
2242:
2238:
2234:
2230:
2225:
2221:
2217:
2214:(6): 1375–7.
2213:
2209:
2203:
2199:
2195:
2191:
2187:
2183:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2142:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2107:
2103:
2099:
2095:
2091:
2086:
2081:
2078:(3): 99–106.
2077:
2073:
2068:
2067:
2062:
2053:
2049:
2044:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2004:
2001:
1996:
1992:
1987:
1982:
1977:
1972:
1968:
1964:
1960:
1953:
1951:
1947:
1942:
1938:
1933:
1928:
1924:
1920:
1916:
1912:
1908:
1901:
1899:
1897:
1893:
1888:
1884:
1879:
1874:
1869:
1864:
1860:
1856:
1852:
1845:
1843:
1841:
1837:
1832:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1797:
1794:
1789:
1783:
1780:
1775:
1771:
1766:
1761:
1757:
1753:
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1717:
1712:
1707:
1702:
1698:
1694:
1690:
1686:
1682:
1675:
1672:
1660:
1656:
1650:
1647:
1642:
1638:
1632:
1629:
1624:
1620:
1614:
1611:
1607:
1603:
1598:
1596:
1594:
1590:
1586:
1582:
1577:
1575:
1573:
1569:
1562:
1560:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1533:neuroblastoma
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1501:
1499:
1495:
1492:
1488:
1484:
1480:
1476:
1472:
1469:that removes
1468:
1464:
1460:
1456:
1451:
1449:
1445:
1441:
1437:
1436:chromosome 16
1433:
1429:
1425:
1421:
1418:, CYLD is an
1417:
1414:
1410:
1397:
1392:
1388:
1384:
1381:
1377:
1370:
1368:
1365:
1361:
1357:
1353:
1350:
1346:
1342:
1335:
1333:
1329:
1325:
1321:
1315:
1311:
1308:
1302:
1300:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1219:
1215:
1208:
1206:
1202:
1198:
1194:
1190:
1184:
1180:
1177:
1171:
1169:
1165:
1161:
1155:
1151:
1148:
1146:RefSeq (mRNA)
1144:
1137:
1136:
1131:
1127:
1124:
1118:
1117:
1112:
1108:
1105:
1103:
1099:
1092:
1091:
1086:
1082:
1079:
1073:
1072:
1067:
1063:
1060:
1058:
1054:
1047:
1046:
1041:
1037:
1034:
1028:
1027:
1022:
1018:
1015:
1013:
1009:
1006:
1003:
1001:
998:
994:
991:
987:
983:
976:
972:
967:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
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901:
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856:
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851:
848:
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836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
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806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
782:
780:
777:
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765:
762:
760:
757:
755:
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750:
747:
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742:
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730:
727:
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715:
712:
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664:
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641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
611:
610:Gene ontology
607:
603:
591:
586:
582:
575:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
495:otolith organ
494:
493:
490:
486:
481:
478:
469:Pars compacta
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
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406:
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389:
385:
381:
377:
369:
364:
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351:
341:
337:
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323:
317:
310:
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298:
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268:
263:
259:
255:
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240:
236:
229:
222:
216:
209:
205:
199:
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191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3724:expanding it
3709:
3694:
3548:SUMO protein
3509:
2828:
2813:
2798:
2739:
2733:
2688:
2684:
2653:
2649:
2610:
2606:
2568:(4): 732–4.
2565:
2561:
2516:
2512:
2461:
2457:
2406:
2402:
2367:
2363:
2329:(2): 160–5.
2326:
2322:
2296:
2292:
2265:
2262:DNA Research
2261:
2232:
2228:
2211:
2207:
2181:
2177:
2147:(4): 441–3.
2144:
2140:
2114:
2110:
2075:
2072:DNA Research
2071:
2017:
2013:
2003:
1966:
1962:
1917:(1): 14–24.
1914:
1910:
1858:
1854:
1806:
1802:
1796:
1782:
1747:
1743:
1733:
1688:
1684:
1674:
1662:. Retrieved
1658:
1649:
1640:
1631:
1622:
1613:
1549:colon cancer
1516:
1504:
1502:
1498:inflammatory
1459:cytoskeletal
1454:
1452:
1430:12.1 on the
1420:evolutionary
1412:
1408:
1406:
1328:NP_001263208
1324:NP_001121643
1320:NP_001121642
1317:
1291:NP_001365684
1287:NP_001365683
1283:NP_001365682
1279:NP_001365681
1275:NP_001365680
1271:NP_001365679
1267:NP_001365678
1263:NP_001365677
1259:NP_001365676
1255:NP_001365675
1251:NP_001365674
1248:
1241:NP_001365673
1237:NP_001365672
1229:NP_001035877
1225:NP_001035814
1201:NM_001276279
1197:NM_001128171
1193:NM_001128170
1189:NM_001128169
1186:
1164:NM_001042412
1160:NM_001042355
1157:
1133:
1114:
1088:
1069:
1043:
1024:
1004:
999:
754:cytoskeleton
527:otic vesicle
407:
400:
127:External IDs
74:
18:
3642:neddylation
2908:Hsp10/GroES
2900:Chaperonins
2781:PDB gallery
2020:(1): 4717.
1861:: 427–444.
1553:lung cancer
905:necroptosis
805:proteolysis
769:ciliary tip
759:microtubule
366:89,478,573
353:89,423,656
345:8|8 C3
265:50,801,935
252:50,742,050
105:Identifiers
3763:Categories
2934:Hsp40/DnaJ
2881:Chaperones
2487:1874/17767
2117:: 217–34.
1608:, May 2017
1587:, May 2017
1563:References
825:cell cycle
704:centrosome
441:lymph node
411:(ortholog)
148:HomoloGene
3774:Oncogenes
3714:on human
3220:Ubiquitin
3166:Clusterin
2080:CiteSeerX
1969:(1): 66.
1471:ubiquitin
1465:, i.e. a
1332:NP_775545
1233:NP_056062
1205:NM_173369
1168:NM_015247
990:Orthologs
694:cytoplasm
156:GeneCards
3500:Ataxin 3
2717:15226292
2672:15086550
2637:14676304
2594:14632188
2541:12917691
2496:12917690
2441:12917689
2394:11042152
2351:22829077
2343:10835629
2313:10480375
2284:10048485
2208:Oncogene
2169:33637152
2131:16350444
2102:12168954
2052:31624251
1995:34454635
1941:32883697
1887:34744449
1831:37088265
1823:17828277
1774:31792733
1725:29394249
1685:PLOS ONE
1604:–
1583:–
1467:protease
1444:proteins
1380:Wikidata
969:Sources:
714:membrane
3423:(CDC34)
2628:2194148
2549:4397177
2521:Bibcode
2504:4416878
2466:Bibcode
2449:4424549
2411:Bibcode
2249:9373149
2220:8649842
2198:8125298
2161:7493027
2043:6797807
2022:Bibcode
1986:8401176
1932:7840145
1878:8566010
1765:7295879
1716:5796713
1693:Bibcode
1664:20 June
1606:Ensembl
1585:Ensembl
1424:sponges
1102:UniProt
1057:Ensembl
996:Species
975:QuickGO
739:midbody
729:spindle
699:cytosol
499:utricle
386:pattern
244:16q12.1
144:1921506
112:Aliases
3467:Cullin
2731:Human
2715:
2670:
2635:
2625:
2592:
2547:
2539:
2513:Nature
2502:
2494:
2458:Nature
2447:
2439:
2403:Nature
2392:
2385:310934
2382:
2349:
2341:
2311:
2282:
2247:
2218:
2196:
2167:
2159:
2129:
2100:
2082:
2050:
2040:
1993:
1983:
1939:
1929:
1885:
1875:
1829:
1821:
1772:
1762:
1723:
1713:
1555:, and
1489:, and
1366:search
1364:PubMed
1135:Q80TQ2
1116:Q9NQC7
1012:Entrez
557:BioGPS
465:tonsil
136:605018
3718:is a
3658:ATG12
3648:FAT10
3638:NEDD8
3623:ISG15
3616:Other
3605:PIAS4
3600:PIAS3
3595:PIAS2
3590:PIAS1
3540:(UBL)
3522:BIRC6
3482:FANCL
3154:Other
3143:TRAP1
3112:Hsp90
3038:Hsp70
2927:GroEL
2923:HSP60
2918:Hsp47
2913:Hsp27
2545:S2CID
2500:S2CID
2445:S2CID
2347:S2CID
2165:S2CID
1827:S2CID
1487:TGF-β
1483:notch
1475:NF-κB
1045:74256
1005:Mouse
1000:Human
971:Amigo
453:sperm
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
3720:stub
3712:gene
3673:UBL5
3663:FUB1
3653:ATG8
3633:UFM1
3628:URM1
3578:UBC9
3566:SAE2
3561:SAE1
3527:UFC1
3517:ATG3
3510:CYLD
3505:USP6
3487:UBR1
3477:MDM2
3276:SAE1
3271:NAE1
3266:ATG7
3261:UBA7
3256:UBA6
3251:UBA5
3246:UBA3
3241:UBA2
3236:UBA1
3181:SMN2
3176:SMN1
2829:1whm
2814:1whl
2799:1ixd
2740:CYLD
2734:CYLD
2713:PMID
2668:PMID
2633:PMID
2590:PMID
2537:PMID
2492:PMID
2437:PMID
2390:PMID
2339:PMID
2309:PMID
2280:PMID
2245:PMID
2229:Gene
2216:PMID
2194:PMID
2178:Gene
2157:PMID
2127:PMID
2098:PMID
2048:PMID
1991:PMID
1937:PMID
1883:PMID
1819:PMID
1770:PMID
1721:PMID
1666:2019
1517:CYLD
1505:CYLD
1503:The
1455:CYLD
1453:The
1440:code
1428:band
1416:gene
1413:CYLD
1407:The
1026:1540
392:Bgee
340:Band
301:Chr.
239:Band
198:Chr.
160:CYLD
152:9069
132:OMIM
119:CYLD
89:2VHF
85:1WHM
81:1WHL
77:1IXD
58:RCSB
55:PDBe
24:CYLD
3668:MUB
3472:CBL
3462:VHL
3455:E3
3284:E2
3229:E1
3098:12A
3029:C19
3024:C14
3019:C13
3014:C11
3009:C10
2964:B11
2703:hdl
2693:doi
2689:279
2658:doi
2654:122
2623:PMC
2615:doi
2611:198
2580:hdl
2570:doi
2566:121
2529:doi
2517:424
2482:hdl
2474:doi
2462:424
2427:hdl
2419:doi
2407:424
2380:PMC
2372:doi
2331:doi
2301:doi
2297:105
2270:doi
2237:doi
2233:200
2186:doi
2182:138
2149:doi
2119:doi
2090:doi
2038:PMC
2030:doi
1981:PMC
1971:doi
1927:PMC
1919:doi
1873:PMC
1863:doi
1811:doi
1760:PMC
1752:doi
1711:PMC
1701:doi
1491:JNK
1479:Wnt
1434:of
362:End
261:End
164:OMA
140:MGI
48:PDB
3765::
3498::
3442:V2
3437:V1
3427:R2
3421:R1
3416:Q2
3411:Q1
3391:L6
3386:L4
3381:L3
3376:L2
3371:L1
3361:J2
3356:J1
3341:G2
3336:G1
3331:E3
3326:E2
3321:E1
3316:D3
3311:D2
3306:D1
3138:ER
3103:14
3068:4L
3053:1L
3048:1B
3043:1A
3004:C7
2999:C6
2994:C5
2989:C3
2984:C1
2979:B9
2974:B6
2969:B4
2959:B2
2954:B1
2949:A3
2944:A2
2939:A1
2711:.
2701:.
2687:.
2683:.
2666:.
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2648:.
2631:.
2621:.
2609:.
2605:.
2588:.
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2337:.
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2243:.
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2212:12
2210:.
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2143:.
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2088:.
2074:.
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2018:10
2016:.
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1989:.
1979:.
1965:.
1961:.
1949:^
1935:.
1925:.
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1895:^
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3125:α
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166::
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