297:
274:
171:
196:
548:
303:
202:
4868:
1448:
experiment with gene-deficient mice has found that the hydroxylation of benzopyrene by CYP1A1 can have an overall protective effect on the DNA, rather than contributing to potentially carcinogenic DNA modifications. This effect is likely due to the fact that CYP1A1 is highly active in the intestinal
1559:, endothelial cell migration and endothelial cell proliferation; and inhibit the growth and metastasis of human breast and prostate cancer cell lines. It is suggested that the EDP and EEQ metabolites function in humans as they do in animal models and that, as products of the
50:
1571:, and therefore act locally. CYP1A1 is one of the main extra-hepatic cytochrome P450 enzymes; it is not regarded as being a major contributor to forming the cited epoxides but could act locally in certain tissues such as the intestine and in certain cancers to do so.
1563:, docosahexaenoic acid and eicosapentaenoic acid, the EDP and EEQ metabolites contribute to many of the beneficial effects attributed to dietary omega-3 fatty acids. EDP and EEQ metabolites are short-lived, being inactivated within seconds or minutes of formation by
2756:
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".
1832:
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".
1992:
Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW (May 2004). "Oral exposure to benzopyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation".
1555:) metabolites have a broad range of activities. In various animal models and in vitro studies on animal and human tissues, they decrease hypertension and pain perception; suppress inflammation; inhibit
1715:, New Eng J Med 1973:289;934-937) Light smokers with the susceptible genotype CYP1A1 have a sevenfold higher risk of developing lung cancer compared to light smokers with the normal genotype.
610:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3518:
310:
209:
3983:
1600:
3567:
2382:
Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von
Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH (Mar 2014).
1903:
Briguglio, M.; Hrelia, S.; Malaguti, M.; Serpe, L.; Canaparo, R.; Dell'Osso, B.; Galentino, R.; De
Michele, S.; Dina, C. Z.; Porta, M.; Banfi, G. (2018).
3739:
1066:
132:
1047:
3721:
3717:
2880:
4345:
3406:
2668:
Crofts F, Taioli E, Trachman J, Cosma GN, Currie D, Toniolo P, Garte SJ (Dec 1994). "Functional significance of different human CYP1A1 genotypes".
4238:
4413:
4152:
3990:
3699:
3223:
1468:
into signaling molecules that have physiological as well as pathological activities. CYP1A1 has monoxygenase activity in that it metabolizes
4888:
1791:
1773:
1540:
responses, and stimulates the growth of various types of tumor cells; however the in vivo ability and significance of 19-HETE in inhibiting
4086:
3643:
3559:
4313:
3884:
3583:
2821:
Hildebrandt AG, Schwarz D, Krusekopf S, Kleeberg U, Roots I (2007). "Recalling P446. P4501A1 (CYP1A1) opting for clinical application".
296:
1290:
4587:
4286:
1297:
3623:
1868:
Smith G, Stubbins MJ, Harries LW, Wolf CR (Dec 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily".
273:
2203:"The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease"
1532:
by CYP1A1 has also been demonstrated. 19-HETE is an inhibitor of 20-HETE, a broadly active signaling molecule, e.g. it constricts
1429:. In this reaction, the oxidation of benzopyrene is catalysed by CYP1A1 to form BaP-7,8-epoxide, which can be further oxidized by
3962:
1434:
1417:
CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (
4325:
4271:
3760:
3601:
3480:
3179:
2625:
Cosma G, Crofts F, Taioli E, Toniolo P, Garte S (1993). "Relationship between genotype and function of the human CYP1A1 gene".
1760:
1739:
1525:
1473:
1418:
1711:
The highly inducible forms of CYP1A1 are associated with an increased risk of lung cancer in smokers. (Reference = Kellerman
3946:
3753:
2122:
Westphal C, Konkel A, Schunck WH (Nov 2011). "CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?".
195:
170:
4743:
1756:
47:
4130:
3657:
3627:
3587:
3575:
2873:
4858:
1735:
3811:
3725:
3713:
112:
2433:
Ma Q, Lu AY (Jul 2007). "CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies".
2159:"AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis"
4554:
4403:
3863:
3563:
3231:
309:
208:
2858:
4145:
3746:
3685:
3681:
3669:
3665:
3661:
1552:
1548:
1465:
302:
201:
4728:
4844:
4831:
4818:
4805:
4792:
4779:
4766:
4549:
4510:
4500:
4486:
4482:
4472:
4460:
4440:
4423:
4391:
4355:
4255:
4182:
4049:
3934:
3703:
1592:
1568:
4738:
4893:
4692:
4635:
4173:
4118:
3856:
3803:
3798:
3653:
3504:
2901:
2866:
1111:
120:
4395:
2384:"Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway"
2036:
Badal S, Delgoda R (Jul 2014). "Role of the modulation of CYP1A1 expression and activity in chemoprevention".
4640:
4186:
3905:
3778:
1652:
1092:
4534:
4450:
4199:
3732:
3677:
3673:
3639:
3571:
3153:
2537:"Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism"
1632:
1628:
1619:
expression thereby modulating the metabolic activation of several environmental carcinogens such as PAHs.
1449:
mucosa, and thus inhibits infiltration of ingested benzopyrene carcinogen into the systemic circulation.
4661:
4580:
4330:
4303:
4138:
3969:
3475:
1505:
1411:
184:
4733:
103:, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX, CYPIA1, cytochrome P450 family 1 subfamily A member 1
4445:
4408:
4169:
3927:
3824:
3695:
3594:
3235:
2634:
2535:
Wohak, L.E.; Krais, A.M.; Kucab, J.E.; Stertmann, J.; Ovrebo, S.; Phillips, D.H.; Arlt, V.M. (2016).
2489:
1596:
1481:
640:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
99:
4697:
4431:
4079:
3785:
3613:
1603:. In the intestine, but not the liver, CYP1A1 expression moreover depends on TOLL-like receptor 2 (
1269:
1248:
1244:
1210:
1189:
1185:
3427:
1905:"Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles"
4630:
4194:
3579:
2846:
2458:
2104:
2061:
2018:
1631:
have been identified in CYP1A1, some of which lead to more highly inducible AHH activity. CYP1A1
1560:
144:
4340:
1273:
1240:
1214:
1181:
4228:
2838:
2809:
2774:
2734:
2685:
2650:
2607:
2566:
2517:
2450:
2415:
2364:
2314:
2273:
2224:
2180:
2139:
2096:
2053:
2010:
1974:
1936:
1885:
1850:
1814:
1608:
1564:
1430:
92:
40:
3057:
4676:
4671:
4645:
4573:
2926:
2830:
2799:
2766:
2724:
2716:
2705:"The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene"
2677:
2642:
2597:
2556:
2548:
2507:
2497:
2442:
2405:
2395:
2354:
2346:
2304:
2263:
2255:
2214:
2170:
2131:
2088:
2045:
2002:
1966:
1926:
1916:
1877:
1842:
1469:
547:
389:
320:
264:
219:
140:
2339:"The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling"
4723:
4707:
4620:
4318:
4028:
2897:
2244:"Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer"
1403:
1387:
1366:
364:
2350:
2135:
2638:
2584:
Petersen DD, McKinney CE, Ikeya K, Smith HH, Bale AE, McBride OW, Nebert DW (Apr 1991).
2493:
4872:
4761:
4702:
4544:
4524:
4519:
4161:
3336:
2729:
2720:
2704:
2602:
2585:
2561:
2536:
2512:
2477:
2410:
2383:
2359:
2338:
2268:
2243:
1931:
1904:
1422:
1433:(EH) to form BaP-7,8-dihydrodiol. Finally, CYP1A1 catalyses this intermediate to form
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
735:
730:
725:
720:
715:
710:
705:
700:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
619:
614:
609:
604:
599:
594:
589:
4882:
4666:
4625:
4111:
4015:
3976:
3898:
3891:
3877:
3837:
3818:
3792:
2770:
1846:
1588:
576:
2108:
2022:
4615:
4363:
4359:
3634:
3608:
3512:
3498:
3491:
3397:
3377:
3370:
3353:
3295:
3278:
3271:
3264:
3257:
3250:
3218:
3211:
2850:
2586:"Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP"
2462:
2065:
1556:
1537:
1391:
382:
161:
2788:"Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review"
2259:
1921:
124:
2502:
1504:-epoxydocosapentaenoic acid isomers (termed 19,20-EDP) and similarly metabolizes
148:
4839:
4774:
4610:
3204:
3160:
2681:
2092:
1796:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1778:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1477:
4867:
2157:
Nguyen, CH; Brenner, S; Huttary, N; Atanasov, AG; Dirsch, VM (September 2016).
465:
4495:
2889:
2834:
2646:
2552:
1970:
1704:
1666:
1648:
1453:
1438:
1395:
1383:
281:
178:
128:
2079:
Go RE, Hwang KA, Choi KC (Mar 2015). "Cytochrome P450 1 family and cancers".
665:
oxidoreductase activity, acting on diphenols and related substances as donors
4813:
4787:
4464:
4427:
4371:
4165:
4104:
3305:
2893:
2309:
2292:
1881:
1700:
1533:
1407:
1399:
1011:
525:
403:
348:
335:
247:
234:
136:
2842:
2813:
2778:
2570:
2521:
2454:
2446:
2419:
2368:
2318:
2277:
2228:
2184:
2143:
2100:
2057:
2014:
1940:
1854:
1818:
2738:
2689:
2654:
2611:
2219:
2202:
2006:
1978:
1889:
1337:
1332:
4243:
4061:
4021:
4008:
3953:
3920:
3870:
3848:
3843:
3829:
2804:
2787:
2175:
2158:
1692:
1685:
1644:
1321:
1156:
1137:
2400:
624:
4539:
3530:
3457:
3447:
3437:
3420:
3410:
3402:
3390:
3386:
3382:
3363:
3315:
3288:
3243:
3239:
3227:
3118:
3113:
3108:
3083:
3078:
3062:
2982:
2977:
2957:
1696:
1681:
1662:
1658:
1640:
1541:
1485:
1456:
has been implicated in the formation of various types of human cancer.
1426:
1353:
1123:
1078:
2293:"Soluble epoxide hydrolase: A potential target for metabolic diseases"
69:
4826:
4596:
4381:
4376:
4335:
3197:
3193:
3183:
3169:
3165:
3133:
3128:
3123:
3103:
3098:
3093:
3088:
3052:
3047:
3042:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2972:
2967:
2962:
2952:
2947:
2931:
2921:
2049:
1670:
1584:
1580:
1305:
1033:
1699:
substitution at nucleotide 2453 leading to an amino acid change of
1665:
substitution at nucleotide 2455 leading to an amino acid change of
4800:
4528:
4263:
4221:
4214:
4209:
4204:
3484:
3346:
3033:
1674:
996:
992:
4308:
4296:
4291:
4281:
4276:
4259:
4233:
3538:
1604:
1524:-eicosatetraenoic acid isomers (termed 17,18-EEQ). Synthesis of
1362:
116:
4569:
4134:
2862:
556:
1612:
2478:"TLR2 controls intestinal carcinogen detoxication by CYP1A1"
847:
positive regulation of G1/S transition of mitotic cell cycle
1688:
substitution at nucleotide 3205 in the 3'-non-coding region
4565:
2476:
Do KN, Fink LN, Jensen TE, Gautier L, Parlesak A (2012).
2081:
The
Journal of Steroid Biochemistry and Molecular Biology
1607:), which recognizes bacterial surface structures such as
372:
1579:
The expression of the CYP1A1 gene, along with that of
4856:
2337:
Wagner K, Vito S, Inceoglu B, Hammock BD (Oct 2014).
1350:
Cytochrome P450, family 1, subfamily A, polypeptide 1
537:
2786:
Masson LF, Sharp L, Cotton SC, Little J (May 2005).
4752:
4716:
4685:
4654:
4603:
4509:
4481:
4459:
4422:
4390:
4354:
4254:
4181:
4096:
4071:
4000:
3770:
3548:
3467:
3325:
3142:
3071:
3031:
2940:
2909:
1262:
1233:
1203:
1174:
1752:
1750:
1748:
1731:
1729:
1727:
1472:to 19-hydroxyeicosatetraenoic acid (19-HETE) (see
319:
218:
2703:Kiyohara C, Hirohata T, Inutsuka S (Jan 1996).
2332:
2330:
2328:
1957:Beresford AP (1993). "CYP1A1: friend or foe?".
1452:CYP1A1 metabolism of various foreign agents to
922:porphyrin-containing compound metabolic process
16:Protein-coding gene in the species Homo sapiens
2627:Journal of Toxicology and Environmental Health
1757:GRCm38: Ensembl release 89: ENSMUSG00000032315
1601:aryl hydrocarbon receptor nuclear translocator
4581:
4146:
2874:
2196:
2194:
1952:
1950:
8:
807:cellular response to organic cyclic compound
1736:GRCh38: Ensembl release 89: ENSG00000140465
4588:
4574:
4566:
4153:
4139:
4131:
2881:
2867:
2859:
2343:Prostaglandins & Other Lipid Mediators
2242:Zhang G, Kodani S, Hammock BD (Jan 2014).
2124:Prostaglandins & Other Lipid Mediators
1007:
982:long-chain fatty acid biosynthetic process
572:
476:transitional epithelium of urinary bladder
360:
259:
156:
58:
2803:
2728:
2601:
2560:
2511:
2501:
2409:
2399:
2358:
2308:
2267:
2218:
2174:
1930:
1920:
1591:transcription factor that consist of the
837:response to arsenic-containing substance
767:9-cis-retinoic acid biosynthetic process
757:maternal process involved in parturition
716:intracellular membrane-bounded organelle
4863:
1723:
2291:He J, Wang C, Zhu Y, Ai D (Dec 2015).
1611:. Additionally, the tumour suppressor
972:hydrogen peroxide biosynthetic process
675:estrogen 16-alpha-hydroxylase activity
18:
962:regulation of lipid metabolic process
324:
285:
280:
223:
182:
177:
7:
4346:24-hydroxycholesterol 7α-hydroxylase
2351:10.1016/j.prostaglandins.2014.09.001
2136:10.1016/j.prostaglandins.2011.09.001
1536:, elevates blood pressure, promotes
2709:Japanese Journal of Cancer Research
1378:Metabolism of xenobiotics and drugs
772:response to organic cyclic compound
600:flavonoid 3'-monooxygenase activity
2721:10.1111/j.1349-7006.1996.tb00194.x
2590:American Journal of Human Genetics
1496:-epoxydocosapentaenoic acid and 19
1259:
1230:
1200:
1171:
1147:
1128:
1102:
1083:
1057:
1038:
872:dibenzo-p-dioxin metabolic process
832:dibenzo-p-dioxin catabolic process
542:
460:
398:
377:
14:
1365:. The protein is a member of the
1356:that in humans is encoded by the
752:response to immobilization stress
650:vitamin D 24-hydroxylase activity
4866:
2792:American Journal of Epidemiology
2771:10.1097/00008571-200401000-00001
1847:10.1097/00008571-200401000-00001
1480:activity in that it metabolizes
1435:BaP-7,8-dihydrodiol-9,10-epoxide
1425:(BaP), by transforming it to an
1419:polycyclic aromatic hydrocarbons
546:
308:
301:
295:
272:
207:
200:
194:
169:
4326:Cholesterol 7 alpha-hydroxylase
4272:Flavin-containing monooxygenase
2435:Drug Metabolism and Disposition
1474:20-Hydroxyeicosatetraenoic acid
1460:Metabolism of endogenous agents
942:cellular response to copper ion
1402:found in lime, sweet orange),
1382:CYP1A1 is involved in phase I
862:omega-hydroxylase P450 pathway
857:response to lipopolysaccharide
711:endoplasmic reticulum membrane
557:More reference expression data
526:More reference expression data
1:
2260:10.1016/j.plipres.2013.11.003
2038:Journal of Applied Toxicology
1922:10.3390/pharmaceutics10040277
1809:Kawajiri K (1999). "CYP1A1".
1516:-eicosatetraenoic acid and 17
967:heterocycle metabolic process
912:cell population proliferation
842:response to organic substance
787:insecticide metabolic process
293:
192:
4889:Genes on human chromosome 15
2503:10.1371/journal.pone.0032309
1811:IARC Scientific Publications
736:mitochondrial inner membrane
620:steroid hydroxylase activity
4555:Deoxyhypusine monooxygenase
2093:10.1016/j.jsbmb.2014.11.003
1544:has not been demonstrated.
1466:polyunsaturated fatty acids
957:response to toxic substance
907:digestive tract development
902:camera-type eye development
887:flavonoid metabolic process
782:vitamin D metabolic process
4910:
2248:Progress in Lipid Research
1553:epoxyeicosatetraenoic acid
1549:epoxydocosapentaenoic acid
927:ethylene metabolic process
822:hepatocyte differentiation
777:coumarin metabolic process
4744:Michaelis–Menten kinetics
4550:Ecdysone 20-monooxygenase
4501:Stearoyl-CoA desaturase-1
4473:Dopamine beta-hydroxylase
4441:Phenylalanine hydroxylase
2835:10.1080/03602530701498026
2682:10.1093/carcin/15.12.2961
2647:10.1080/15287399309531796
2553:10.1007/s00204-014-1409-1
2388:Journal of Lipid Research
1971:10.3109/03602539308993984
1792:"Mouse PubMed Reference:"
1774:"Human PubMed Reference:"
1615:has been shown to impact
1593:aryl hydrocarbon receptor
1587:genes, is regulated by a
1569:soluble epoxide hydrolase
1508:to epoxides, primarily 17
1336:
1331:
1327:
1320:
1304:
1285:
1266:
1237:
1226:
1207:
1178:
1167:
1154:
1150:
1135:
1131:
1122:
1109:
1105:
1090:
1086:
1077:
1064:
1060:
1045:
1041:
1032:
1017:
1010:
1006:
990:
937:steroid metabolic process
882:response to iron(III) ion
575:
571:
554:
545:
536:
523:
472:
463:
450:mucosa of urinary bladder
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
4636:Diffusion-limited enzyme
1464:CYP1A1 also metabolizes
1390:(one substrate of it is
1369:superfamily of enzymes.
1291:Chr 15: 74.72 – 74.73 Mb
827:epoxygenase P450 pathway
2823:Drug Metabolism Reviews
2310:10.1111/1753-0407.12358
2207:Pharmacological Reviews
1959:Drug Metabolism Reviews
1882:10.1080/004982598238868
952:toxin metabolic process
947:amine metabolic process
655:oxidoreductase activity
4535:Squalene monooxygenase
4451:Tryptophan hydroxylase
4200:HIF prolyl-hydroxylase
2447:10.1124/dmd.107.015826
2201:Fleming I (Oct 2014).
1995:Molecular Pharmacology
1394:). It is inhibited by
1298:Chr 9: 57.6 – 57.61 Mb
797:response to antibiotic
670:monooxygenase activity
4729:Eadie–Hofstee diagram
4662:Allosteric regulation
4331:Methane monooxygenase
4304:Nitric oxide synthase
2220:10.1124/pr.113.007781
2007:10.1124/mol.65.5.1225
1595:, a ligand activated
1506:eicosapentaenoic acid
1421:, PAH), for example,
1412:aromatic hydrocarbons
977:developmental process
917:response to herbicide
852:response to vitamin A
792:response to hyperoxia
726:endoplasmic reticulum
685:Hsp90 protein binding
680:Hsp70 protein binding
185:Chromosome 15 (human)
4739:Lineweaver–Burk plot
4446:Tyrosine hydroxylase
4170:steroid hydroxylases
1653:3'-non-coding region
1597:transcription factor
1482:docosahexaenoic acid
877:response to nematode
867:response to wounding
605:demethylase activity
504:skin of external ear
484:olfactory epithelium
287:Chromosome 9 (mouse)
62:List of PDB id codes
35:Available structures
4396:iron–sulfur protein
2639:1993JTEH...40..309C
2494:2012PLoSO...732309D
2401:10.1194/jlr.M047357
2297:Journal of Diabetes
1561:omega-3 fatty acids
932:lipid hydroxylation
762:response to hypoxia
434:epithelium of colon
430:right lobe of liver
422:islet of Langerhans
326:9 B|9 31.34 cM
4698:Enzyme superfamily
4631:Enzyme promiscuity
4195:Prolyl hydroxylase
2805:10.1093/aje/kwi121
2176:10.1093/hmg/ddw329
1565:epoxide hydrolases
1112:ENSMUSG00000032315
745:Biological process
706:organelle membrane
694:Cellular component
660:aromatase activity
625:catalytic activity
583:Molecular function
149:CYP1A1 - orthologs
4854:
4853:
4563:
4562:
4229:Lysyl hydroxylase
4128:
4127:
2345:. 113–115: 2–12.
1609:lipoteichoic acid
1431:epoxide hydrolase
1347:
1346:
1343:
1342:
1316:
1315:
1281:
1280:
1256:
1255:
1222:
1221:
1197:
1196:
1163:
1162:
1144:
1143:
1118:
1117:
1099:
1098:
1073:
1072:
1054:
1053:
1002:
1001:
897:liver development
812:response to virus
615:metal ion binding
567:
566:
563:
562:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
4901:
4871:
4870:
4862:
4734:Hanes–Woolf plot
4677:Enzyme activator
4672:Enzyme inhibitor
4646:Enzyme catalysis
4590:
4583:
4576:
4567:
4155:
4148:
4141:
4132:
2900:(Most belong to
2883:
2876:
2869:
2860:
2854:
2817:
2807:
2782:
2759:Pharmacogenetics
2743:
2742:
2732:
2700:
2694:
2693:
2665:
2659:
2658:
2622:
2616:
2615:
2605:
2581:
2575:
2574:
2564:
2532:
2526:
2525:
2515:
2505:
2473:
2467:
2466:
2430:
2424:
2423:
2413:
2403:
2394:(6): 1150–1164.
2379:
2373:
2372:
2362:
2334:
2323:
2322:
2312:
2288:
2282:
2281:
2271:
2239:
2233:
2232:
2222:
2198:
2189:
2188:
2178:
2154:
2148:
2147:
2119:
2113:
2112:
2076:
2070:
2069:
2050:10.1002/jat.2968
2033:
2027:
2026:
1989:
1983:
1982:
1954:
1945:
1944:
1934:
1924:
1900:
1894:
1893:
1865:
1859:
1858:
1835:Pharmacogenetics
1829:
1823:
1822:
1806:
1800:
1799:
1788:
1782:
1781:
1770:
1764:
1754:
1743:
1733:
1647:substitution at
1470:arachidonic acid
1404:fluoroquinolones
1329:
1328:
1300:
1293:
1276:
1260:
1251:
1231:
1227:RefSeq (protein)
1217:
1201:
1192:
1172:
1148:
1129:
1103:
1084:
1058:
1039:
1008:
892:response to food
590:iron ion binding
573:
559:
550:
543:
528:
468:
466:Top expressed in
461:
442:cartilage tissue
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
4909:
4908:
4904:
4903:
4902:
4900:
4899:
4898:
4894:Cytochrome P450
4879:
4878:
4877:
4865:
4857:
4855:
4850:
4762:Oxidoreductases
4748:
4724:Enzyme kinetics
4712:
4708:List of enzymes
4681:
4650:
4621:Catalytic triad
4599:
4594:
4564:
4559:
4513:- miscellaneous
4505:
4477:
4455:
4418:
4386:
4350:
4341:14α-demethylase
4250:
4177:
4162:Oxidoreductases
4159:
4129:
4124:
4092:
4067:
4029:Halloween genes
3996:
3766:
3544:
3463:
3321:
3138:
3067:
3027:
2936:
2905:
2898:cytochrome P450
2887:
2857:
2829:(2–3): 323–41.
2820:
2785:
2755:
2751:
2749:Further reading
2746:
2702:
2701:
2697:
2667:
2666:
2662:
2633:(2–3): 309–16.
2624:
2623:
2619:
2583:
2582:
2578:
2534:
2533:
2529:
2475:
2474:
2470:
2432:
2431:
2427:
2381:
2380:
2376:
2336:
2335:
2326:
2290:
2289:
2285:
2241:
2240:
2236:
2200:
2199:
2192:
2156:
2155:
2151:
2130:(1–4): 99–108.
2121:
2120:
2116:
2078:
2077:
2073:
2035:
2034:
2030:
1991:
1990:
1986:
1956:
1955:
1948:
1902:
1901:
1897:
1876:(12): 1129–65.
1867:
1866:
1862:
1831:
1830:
1826:
1813:(148): 159–72.
1808:
1807:
1803:
1790:
1789:
1785:
1772:
1771:
1767:
1755:
1746:
1734:
1725:
1721:
1625:
1577:
1567:, particularly
1476:) but also has
1462:
1410:and induced by
1388:drug metabolism
1380:
1375:
1367:cytochrome P450
1338:View/Edit Mouse
1333:View/Edit Human
1296:
1289:
1286:Location (UCSC)
1272:
1268:
1247:
1243:
1239:
1213:
1209:
1188:
1184:
1180:
1093:ENSG00000140465
986:
740:
689:
630:protein binding
555:
524:
515:
512:skin of abdomen
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
438:urinary bladder
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
4907:
4905:
4897:
4896:
4891:
4881:
4880:
4876:
4875:
4852:
4851:
4849:
4848:
4835:
4822:
4809:
4796:
4783:
4770:
4756:
4754:
4750:
4749:
4747:
4746:
4741:
4736:
4731:
4726:
4720:
4718:
4714:
4713:
4711:
4710:
4705:
4700:
4695:
4689:
4687:
4686:Classification
4683:
4682:
4680:
4679:
4674:
4669:
4664:
4658:
4656:
4652:
4651:
4649:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4607:
4605:
4601:
4600:
4595:
4593:
4592:
4585:
4578:
4570:
4561:
4560:
4558:
4557:
4552:
4547:
4542:
4537:
4532:
4525:Heme oxygenase
4522:
4520:Cyclooxygenase
4516:
4514:
4507:
4506:
4504:
4503:
4498:
4492:
4490:
4479:
4478:
4476:
4475:
4469:
4467:
4457:
4456:
4454:
4453:
4448:
4443:
4437:
4435:
4420:
4419:
4417:
4416:
4411:
4406:
4400:
4398:
4388:
4387:
4385:
4384:
4379:
4374:
4368:
4366:
4352:
4351:
4349:
4348:
4343:
4338:
4333:
4328:
4323:
4322:
4321:
4316:
4311:
4301:
4300:
4299:
4294:
4289:
4284:
4279:
4268:
4266:
4252:
4251:
4249:
4248:
4247:
4246:
4241:
4231:
4226:
4225:
4224:
4219:
4218:
4217:
4212:
4207:
4191:
4189:
4187:2-oxoglutarate
4179:
4178:
4160:
4158:
4157:
4150:
4143:
4135:
4126:
4125:
4123:
4122:
4115:
4108:
4100:
4098:
4094:
4093:
4091:
4090:
4083:
4075:
4073:
4069:
4068:
4066:
4065:
4058:
4026:
4025:
4024:
4012:
4004:
4002:
3998:
3997:
3995:
3994:
3987:
3980:
3973:
3966:
3959:
3958:
3957:
3950:
3938:
3931:
3924:
3917:
3916:
3915:
3912:
3902:
3895:
3888:
3881:
3874:
3867:
3860:
3853:
3852:
3851:
3846:
3834:
3833:
3832:
3827:
3815:
3808:
3807:
3806:
3801:
3789:
3782:
3774:
3772:
3768:
3767:
3765:
3764:
3757:
3750:
3743:
3736:
3729:
3707:
3689:
3647:
3631:
3617:
3605:
3598:
3591:
3552:
3550:
3546:
3545:
3543:
3542:
3535:
3534:
3533:
3523:
3522:
3521:
3509:
3508:
3507:
3495:
3488:
3471:
3469:
3465:
3464:
3462:
3461:
3451:
3441:
3431:
3424:
3414:
3394:
3374:
3367:
3357:
3350:
3340:
3329:
3327:
3323:
3322:
3320:
3319:
3309:
3299:
3292:
3282:
3275:
3268:
3261:
3254:
3247:
3215:
3208:
3201:
3187:
3173:
3157:
3146:
3144:
3140:
3139:
3137:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3075:
3073:
3069:
3068:
3066:
3065:
3060:
3055:
3050:
3045:
3039:
3037:
3029:
3028:
3026:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2950:
2944:
2942:
2938:
2937:
2935:
2934:
2929:
2924:
2919:
2913:
2911:
2907:
2906:
2888:
2886:
2885:
2878:
2871:
2863:
2856:
2855:
2818:
2798:(10): 901–15.
2783:
2752:
2750:
2747:
2745:
2744:
2695:
2676:(12): 2961–3.
2670:Carcinogenesis
2660:
2617:
2576:
2547:(2): 291–304.
2527:
2468:
2441:(7): 1009–16.
2425:
2374:
2324:
2283:
2234:
2213:(4): 1106–40.
2190:
2149:
2114:
2071:
2028:
2001:(5): 1225–37.
1984:
1946:
1895:
1860:
1824:
1801:
1783:
1765:
1744:
1722:
1720:
1717:
1709:
1708:
1689:
1678:
1655:
1624:
1621:
1576:
1573:
1488:, primarily 19
1461:
1458:
1379:
1376:
1374:
1371:
1345:
1344:
1341:
1340:
1335:
1325:
1324:
1318:
1317:
1314:
1313:
1311:
1309:
1302:
1301:
1294:
1287:
1283:
1282:
1279:
1278:
1264:
1263:
1257:
1254:
1253:
1235:
1234:
1228:
1224:
1223:
1220:
1219:
1205:
1204:
1198:
1195:
1194:
1176:
1175:
1169:
1165:
1164:
1161:
1160:
1152:
1151:
1145:
1142:
1141:
1133:
1132:
1126:
1120:
1119:
1116:
1115:
1107:
1106:
1100:
1097:
1096:
1088:
1087:
1081:
1075:
1074:
1071:
1070:
1062:
1061:
1055:
1052:
1051:
1043:
1042:
1036:
1030:
1029:
1024:
1019:
1015:
1014:
1004:
1003:
1000:
999:
988:
987:
985:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
748:
746:
742:
741:
739:
738:
733:
728:
723:
718:
713:
708:
703:
697:
695:
691:
690:
688:
687:
682:
677:
672:
667:
662:
657:
652:
647:
645:enzyme binding
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
595:oxygen binding
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
418:jejunal mucosa
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4906:
4895:
4892:
4890:
4887:
4886:
4884:
4874:
4869:
4864:
4860:
4846:
4842:
4841:
4836:
4833:
4829:
4828:
4823:
4820:
4816:
4815:
4810:
4807:
4803:
4802:
4797:
4794:
4790:
4789:
4784:
4781:
4777:
4776:
4771:
4768:
4764:
4763:
4758:
4757:
4755:
4751:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4721:
4719:
4715:
4709:
4706:
4704:
4703:Enzyme family
4701:
4699:
4696:
4694:
4691:
4690:
4688:
4684:
4678:
4675:
4673:
4670:
4668:
4667:Cooperativity
4665:
4663:
4660:
4659:
4657:
4653:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4626:Oxyanion hole
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4608:
4606:
4602:
4598:
4591:
4586:
4584:
4579:
4577:
4572:
4571:
4568:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4530:
4526:
4523:
4521:
4518:
4517:
4515:
4512:
4508:
4502:
4499:
4497:
4494:
4493:
4491:
4488:
4484:
4480:
4474:
4471:
4470:
4468:
4466:
4462:
4458:
4452:
4449:
4447:
4444:
4442:
4439:
4438:
4436:
4433:
4432:BH4 dependent
4429:
4425:
4421:
4415:
4412:
4410:
4407:
4405:
4402:
4401:
4399:
4397:
4393:
4389:
4383:
4380:
4378:
4375:
4373:
4370:
4369:
4367:
4365:
4361:
4357:
4353:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4320:
4317:
4315:
4312:
4310:
4307:
4306:
4305:
4302:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4274:
4273:
4270:
4269:
4267:
4265:
4261:
4257:
4253:
4245:
4242:
4240:
4237:
4236:
4235:
4232:
4230:
4227:
4223:
4220:
4216:
4213:
4211:
4208:
4206:
4203:
4202:
4201:
4198:
4197:
4196:
4193:
4192:
4190:
4188:
4184:
4180:
4175:
4171:
4167:
4163:
4156:
4151:
4149:
4144:
4142:
4137:
4136:
4133:
4121:
4120:
4116:
4114:
4113:
4109:
4107:
4106:
4102:
4101:
4099:
4095:
4089:
4088:
4084:
4082:
4081:
4077:
4076:
4074:
4070:
4064:
4063:
4059:
4056:
4052:
4051:
4046:
4042:
4038:
4034:
4030:
4027:
4023:
4020:
4019:
4018:
4017:
4013:
4011:
4010:
4006:
4005:
4003:
3999:
3993:
3992:
3988:
3986:
3985:
3981:
3979:
3978:
3974:
3972:
3971:
3967:
3965:
3964:
3960:
3956:
3955:
3951:
3949:
3948:
3944:
3943:
3942:
3939:
3937:
3936:
3932:
3930:
3929:
3925:
3923:
3922:
3918:
3913:
3910:
3909:
3908:
3907:
3903:
3901:
3900:
3896:
3894:
3893:
3889:
3887:
3886:
3882:
3880:
3879:
3875:
3873:
3872:
3868:
3866:
3865:
3861:
3859:
3858:
3854:
3850:
3847:
3845:
3842:
3841:
3840:
3839:
3835:
3831:
3828:
3826:
3823:
3822:
3821:
3820:
3816:
3814:
3813:
3809:
3805:
3802:
3800:
3797:
3796:
3795:
3794:
3790:
3788:
3787:
3783:
3781:
3780:
3776:
3775:
3773:
3769:
3763:
3762:
3758:
3756:
3755:
3751:
3749:
3748:
3744:
3742:
3741:
3737:
3735:
3734:
3730:
3727:
3723:
3719:
3715:
3711:
3708:
3705:
3701:
3697:
3693:
3690:
3687:
3683:
3679:
3675:
3671:
3667:
3663:
3659:
3655:
3651:
3648:
3645:
3641:
3637:
3636:
3632:
3629:
3625:
3621:
3618:
3615:
3611:
3610:
3606:
3604:
3603:
3599:
3597:
3596:
3592:
3589:
3585:
3581:
3577:
3573:
3569:
3565:
3561:
3557:
3554:
3553:
3551:
3547:
3541:
3540:
3536:
3532:
3529:
3528:
3527:
3524:
3520:
3517:
3516:
3515:
3514:
3510:
3506:
3503:
3502:
3501:
3500:
3496:
3494:
3493:
3489:
3486:
3482:
3478:
3477:
3473:
3472:
3470:
3466:
3459:
3455:
3452:
3449:
3445:
3442:
3439:
3435:
3432:
3430:
3429:
3425:
3422:
3418:
3415:
3412:
3408:
3404:
3400:
3399:
3395:
3392:
3388:
3384:
3380:
3379:
3375:
3373:
3372:
3368:
3365:
3361:
3358:
3356:
3355:
3351:
3348:
3344:
3341:
3338:
3334:
3331:
3330:
3328:
3324:
3317:
3313:
3310:
3307:
3303:
3300:
3298:
3297:
3293:
3290:
3286:
3283:
3281:
3280:
3276:
3274:
3273:
3269:
3267:
3266:
3262:
3260:
3259:
3255:
3253:
3252:
3248:
3245:
3241:
3237:
3233:
3229:
3225:
3221:
3220:
3216:
3214:
3213:
3209:
3207:
3206:
3202:
3199:
3195:
3191:
3188:
3185:
3181:
3177:
3174:
3171:
3167:
3163:
3162:
3158:
3155:
3151:
3148:
3147:
3145:
3141:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3076:
3074:
3070:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3040:
3038:
3035:
3030:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2945:
2943:
2939:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2914:
2912:
2908:
2903:
2899:
2895:
2891:
2884:
2879:
2877:
2872:
2870:
2865:
2864:
2861:
2852:
2848:
2844:
2840:
2836:
2832:
2828:
2824:
2819:
2815:
2811:
2806:
2801:
2797:
2793:
2789:
2784:
2780:
2776:
2772:
2768:
2764:
2760:
2754:
2753:
2748:
2740:
2736:
2731:
2726:
2722:
2718:
2714:
2710:
2706:
2699:
2696:
2691:
2687:
2683:
2679:
2675:
2671:
2664:
2661:
2656:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2621:
2618:
2613:
2609:
2604:
2599:
2595:
2591:
2587:
2580:
2577:
2572:
2568:
2563:
2558:
2554:
2550:
2546:
2542:
2538:
2531:
2528:
2523:
2519:
2514:
2509:
2504:
2499:
2495:
2491:
2488:(3): e32309.
2487:
2483:
2479:
2472:
2469:
2464:
2460:
2456:
2452:
2448:
2444:
2440:
2436:
2429:
2426:
2421:
2417:
2412:
2407:
2402:
2397:
2393:
2389:
2385:
2378:
2375:
2370:
2366:
2361:
2356:
2352:
2348:
2344:
2340:
2333:
2331:
2329:
2325:
2320:
2316:
2311:
2306:
2303:(3): 305–13.
2302:
2298:
2294:
2287:
2284:
2279:
2275:
2270:
2265:
2261:
2257:
2253:
2249:
2245:
2238:
2235:
2230:
2226:
2221:
2216:
2212:
2208:
2204:
2197:
2195:
2191:
2186:
2182:
2177:
2172:
2168:
2164:
2163:Hum Mol Genet
2160:
2153:
2150:
2145:
2141:
2137:
2133:
2129:
2125:
2118:
2115:
2110:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2075:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2044:(7): 743–53.
2043:
2039:
2032:
2029:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1988:
1985:
1980:
1976:
1972:
1968:
1965:(4): 503–17.
1964:
1960:
1953:
1951:
1947:
1942:
1938:
1933:
1928:
1923:
1918:
1914:
1910:
1909:Pharmaceutics
1906:
1899:
1896:
1891:
1887:
1883:
1879:
1875:
1871:
1864:
1861:
1856:
1852:
1848:
1844:
1840:
1836:
1828:
1825:
1820:
1816:
1812:
1805:
1802:
1797:
1793:
1787:
1784:
1779:
1775:
1769:
1766:
1762:
1758:
1753:
1751:
1749:
1745:
1741:
1737:
1732:
1730:
1728:
1724:
1718:
1716:
1714:
1706:
1702:
1698:
1694:
1690:
1687:
1683:
1679:
1676:
1672:
1668:
1664:
1660:
1656:
1654:
1650:
1646:
1642:
1638:
1637:
1636:
1634:
1633:polymorphisms
1630:
1629:polymorphisms
1623:Polymorphisms
1622:
1620:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1589:heterodimeric
1586:
1582:
1574:
1572:
1570:
1566:
1562:
1558:
1554:
1550:
1545:
1543:
1539:
1535:
1531:
1529:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1459:
1457:
1455:
1450:
1447:
1442:
1440:
1437:, which is a
1436:
1432:
1428:
1424:
1420:
1415:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1377:
1372:
1370:
1368:
1364:
1361:
1360:
1355:
1351:
1339:
1334:
1330:
1326:
1323:
1319:
1312:
1310:
1307:
1303:
1299:
1295:
1292:
1288:
1284:
1277:
1275:
1271:
1265:
1261:
1258:
1252:
1250:
1246:
1242:
1236:
1232:
1229:
1225:
1218:
1216:
1212:
1206:
1202:
1199:
1193:
1191:
1187:
1183:
1177:
1173:
1170:
1168:RefSeq (mRNA)
1166:
1159:
1158:
1153:
1149:
1146:
1140:
1139:
1134:
1130:
1127:
1125:
1121:
1114:
1113:
1108:
1104:
1101:
1095:
1094:
1089:
1085:
1082:
1080:
1076:
1069:
1068:
1063:
1059:
1056:
1050:
1049:
1044:
1040:
1037:
1035:
1031:
1028:
1025:
1023:
1020:
1016:
1013:
1009:
1005:
998:
994:
989:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
802:demethylation
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
749:
747:
744:
743:
737:
734:
732:
731:mitochondrion
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
698:
696:
693:
692:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
4840:Translocases
4837:
4824:
4811:
4798:
4785:
4775:Transferases
4772:
4759:
4616:Binding site
4364:flavoprotein
4168:, including
4166:dioxygenases
4117:
4110:
4103:
4085:
4078:
4060:
4054:
4048:
4044:
4040:
4036:
4032:
4014:
4007:
3989:
3982:
3975:
3968:
3961:
3952:
3945:
3940:
3933:
3926:
3919:
3904:
3897:
3890:
3883:
3876:
3869:
3862:
3855:
3836:
3817:
3810:
3791:
3784:
3777:
3759:
3752:
3745:
3738:
3731:
3709:
3691:
3649:
3633:
3619:
3607:
3600:
3593:
3555:
3537:
3525:
3511:
3497:
3490:
3474:
3453:
3443:
3433:
3426:
3416:
3396:
3376:
3369:
3359:
3352:
3342:
3332:
3311:
3301:
3294:
3284:
3277:
3270:
3263:
3256:
3249:
3217:
3210:
3203:
3189:
3175:
3159:
3149:
2916:
2826:
2822:
2795:
2791:
2762:
2758:
2715:(1): 18–24.
2712:
2708:
2698:
2673:
2669:
2663:
2630:
2626:
2620:
2596:(4): 720–5.
2593:
2589:
2579:
2544:
2541:Arch Toxicol
2540:
2530:
2485:
2481:
2471:
2438:
2434:
2428:
2391:
2387:
2377:
2342:
2300:
2296:
2286:
2251:
2247:
2237:
2210:
2206:
2166:
2162:
2152:
2127:
2123:
2117:
2084:
2080:
2074:
2041:
2037:
2031:
1998:
1994:
1987:
1962:
1958:
1912:
1908:
1898:
1873:
1869:
1863:
1838:
1834:
1827:
1810:
1804:
1795:
1786:
1777:
1768:
1712:
1710:
1707:at codon 461
1651:3801 in the
1626:
1616:
1578:
1557:angiogenesis
1546:
1538:inflammation
1527:
1521:
1517:
1513:
1509:
1501:
1497:
1493:
1489:
1463:
1451:
1445:
1444:However, an
1443:
1416:
1392:theophylline
1381:
1358:
1357:
1349:
1348:
1270:NP_001129531
1267:
1249:NP_001306146
1245:NP_001306145
1238:
1211:NM_001136059
1208:
1190:NM_001319217
1186:NM_001319216
1179:
1155:
1136:
1110:
1091:
1065:
1046:
1026:
1021:
817:human ageing
635:heme binding
388:
381:
108:External IDs
67:
4611:Active site
2890:Cytochromes
2765:(1): 1–18.
1870:Xenobiotica
1841:(1): 1–18.
1551:) and EEQ (
1478:epoxygenase
1454:carcinogens
1423:benzopyrene
446:skin of leg
347:57,611,107
334:57,595,211
246:74,725,536
233:74,719,542
86:Identifiers
4883:Categories
4814:Isomerases
4788:Hydrolases
4655:Regulation
4496:Tyrosinase
4463:: reduced
4426:: reduced
4394:: reduced
4358:: reduced
4097:CYP701-999
4072:CYP501-699
4001:CYP301-499
3771:CYP101-281
2894:oxygenases
2254:: 108–23.
2169:: ddw329.
1915:(4): 277.
1763:, May 2017
1742:, May 2017
1719:References
1705:asparagine
1667:isoleucine
1649:nucleotide
1599:, and the
1575:Regulation
1534:arterioles
1439:carcinogen
1408:macrolides
1396:hesperetin
1384:xenobiotic
492:right lung
392:(ortholog)
129:HomoloGene
4693:EC number
4465:ascorbate
4428:pteridine
4105:CYP704B22
2087:: 24–30.
1701:threonine
1635:include:
1547:The EDP (
1400:flavonoid
1274:NP_034122
1241:NP_000490
1215:NM_009992
1182:NM_000499
1012:Orthologs
701:cytoplasm
137:GeneCards
4717:Kinetics
4641:Cofactor
4604:Activity
4119:CYP720A1
4087:CYP504B1
4062:CYP318A1
4055:CYP315A1
4050:CYP314A1
4045:CYP307A2
4041:CYP307A1
4037:CYP306A1
4033:CYP302A1
4009:CYP303A1
3984:CYP199A2
3963:CYP176A1
3921:CYP154C3
3885:CYP125A1
3871:CYP119A1
3864:CYP113A1
3812:CYP106A2
3786:CYP102A1
3779:CYP101A1
3549:CYP71-99
3468:CYP51-69
3326:CYP21-49
2843:17786624
2814:15870154
2779:15128046
2571:25398514
2522:22442665
2482:PLOS ONE
2455:17431034
2420:24634501
2369:25240260
2319:26621325
2278:24345640
2229:25244930
2185:27677308
2144:21945326
2109:19395455
2101:25448748
2058:24532440
2023:24627183
2015:15102951
1941:30558213
1855:15128046
1819:10493257
1759:–
1738:–
1627:Several
1486:epoxides
1373:Function
1322:Wikidata
991:Sources:
721:membrane
488:gastrula
414:testicle
4873:Biology
4827:Ligases
4597:Enzymes
4511:1.14.99
4489:: other
4483:1.14.18
4461:1.14.17
4424:1.14.16
4392:1.14.15
4356:1.14.14
4256:1.14.13
4183:1.14.11
3991:CYP255A
3970:CYP183A
3935:CYP161C
3928:CYP158A
3761:CYP99A3
3754:CYP97C1
3747:CYP93E1
3740:CYP90C1
3733:CYP88D6
3602:CYP73A1
3595:CYP72A1
3143:CYP5-20
2851:9153325
2739:8609043
2730:5920980
2690:8001264
2655:7901425
2635:Bibcode
2612:1707592
2603:1682951
2562:4748000
2513:3307708
2490:Bibcode
2463:7512239
2411:4031946
2360:4254344
2269:3914417
2066:7634080
1979:8313840
1932:6321138
1890:9890157
1761:Ensembl
1740:Ensembl
1542:20-HETE
1446:in vivo
1427:epoxide
1354:protein
1124:UniProt
1079:Ensembl
1018:Species
997:QuickGO
508:jejunum
426:trachea
367:pattern
225:15q24.1
93:Aliases
4859:Portal
4801:Lyases
4360:flavin
4239:ALKBH1
4112:CYP710
4080:CYP503
4016:CYP305
3977:CYP197
3941:CYP170
3906:CYP152
3899:CYP147
3892:CYP139
3878:CYP123
3857:CYP111
3838:CYP109
3819:CYP107
3793:CYP105
3032:CYP3 (
2849:
2841:
2812:
2777:
2737:
2727:
2688:
2653:
2610:
2600:
2569:
2559:
2520:
2510:
2461:
2453:
2418:
2408:
2367:
2357:
2317:
2276:
2266:
2227:
2183:
2142:
2107:
2099:
2064:
2056:
2021:
2013:
1977:
1939:
1929:
1888:
1853:
1817:
1713:et al.
1671:valine
1617:CYP1A1
1581:CYP1A2
1530:)-HETE
1359:CYP1A1
1308:search
1306:PubMed
1157:P00184
1138:P04798
1034:Entrez
538:BioGPS
500:embryo
496:embryo
141:CYP1A1
117:108330
100:CYP1A1
22:CYP1A1
4753:Types
4529:HMOX1
4264:NADPH
4222:P4HTM
4215:EGLN3
4210:EGLN2
4205:EGLN1
4176:1.14)
3710:CYP81
3692:CYP80
3650:CYP79
3635:CYP76
3620:CYP75
3609:CYP74
3556:CYP71
3539:CYP61
3526:CYP56
3513:CYP55
3499:CYP53
3492:CYP52
3476:CYP51
3454:CYP46
3444:CYP39
3434:CYP35
3428:CYP29
3417:CYP28
3398:CYP27
3378:CYP26
3371:CYP25
3360:CYP24
3354:CYP23
3343:CYP22
3333:CYP21
3312:CYP20
3302:CYP19
3296:CYP18
3285:CYP17
3279:CYP16
3272:CYP15
3265:CYP14
3258:CYP13
3251:CYP12
3219:CYP11
3212:CYP10
3034:CYP3A
2904:1.14)
2847:S2CID
2459:S2CID
2105:S2CID
2062:S2CID
2019:S2CID
1675:codon
1406:and
1352:is a
1067:13076
1027:Mouse
1022:Human
993:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:68062
125:88588
4845:list
4838:EC7
4832:list
4825:EC6
4819:list
4812:EC5
4806:list
4799:EC4
4793:list
4786:EC3
4780:list
4773:EC2
4767:list
4760:EC1
4545:21A2
4540:17A1
4414:11A1
4409:11B2
4404:11B1
4372:19A1
4319:NOS3
4314:NOS2
4309:NOS1
4297:FMO5
4292:FMO4
4287:FMO3
4282:FMO2
4277:FMO1
4260:NADH
4234:AlkB
3205:CYP9
3190:CYP8
3176:CYP7
3161:CYP6
3150:CYP5
3072:CYP4
2941:CYP2
2910:CYP1
2839:PMID
2810:PMID
2775:PMID
2735:PMID
2686:PMID
2651:PMID
2608:PMID
2567:PMID
2518:PMID
2451:PMID
2416:PMID
2365:PMID
2315:PMID
2274:PMID
2225:PMID
2181:PMID
2140:PMID
2097:PMID
2054:PMID
2011:PMID
1975:PMID
1937:PMID
1886:PMID
1851:PMID
1815:PMID
1691:M4,
1680:M3,
1657:M2,
1639:M1,
1605:TLR2
1386:and
1363:gene
1048:1543
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:4I8V
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48:PDBe
4382:2E1
4377:2D6
4362:or
4336:3A4
4262:or
4244:FTO
3588:BA1
3584:AV1
3580:AJ4
3119:F22
3114:F12
3109:F11
3084:A22
3079:A11
3063:A43
3058:A37
2983:C19
2978:C18
2958:A13
2831:doi
2800:doi
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2725:PMC
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2643:doi
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2508:PMC
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2406:PMC
2396:doi
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2347:doi
2305:doi
2264:PMC
2256:doi
2215:doi
2171:doi
2132:doi
2089:doi
2085:147
2046:doi
2003:doi
1967:doi
1927:PMC
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1843:doi
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1673:at
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1613:p53
1585:1B1
1526:12(
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1512:,18
1500:,20
1492:,20
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1398:(a
480:lip
343:End
242:End
145:OMA
121:MGI
41:PDB
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3421:A1
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3409:,
3407:B1
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3403:A1
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3166:G1
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2998:F1
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2968:C8
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