1568:. For example, in a 2017 study, the variant rs2860905 showed stronger association with warfarin sensitivity (<4 mg/day) than common variants CYP2C9*2 and CYP2C9*3. Allele A (23% global frequency) is associated with a decreased dose of warfarin as compared to the allele G (77% global frequency). Another variant, rs4917639, according to a 2009 study, has a strong effect on warfarin sensitivity, almost the same as if CYP2C9*2 and CYP2C9*3 were combined into a single allele. The C allele at rs4917639 has 19% global frequency. Patients with the CC or CA genotype may require decreased dose of warfarin as compared to patients with the wild-type AA genotype. Another variant, rs7089580 with T allele having 14% global frequency, is associated with increased CYP2C9 gene expression. Carriers of AT and TT genotypes at rs7089580 had increased CYP2C9 expression levels compared to wild-type AA genotype. Increased gene expression due to rs7089580 T allele leads to an increased rate of warfarin metabolism and increased warfarin dose requirements. In a study published in 2014, the AT genotype showed slightly higher expression than TT, but both much higher than AA. Another variant, rs1934969 (in studies of 2012 and 2014) have been shown to affect the ability to metabolize losartan: carriers of the TT genotype have increased CYP2C9 hydroxylation capacity for losartan comparing to AA genotype, and, as a result, the lower metabolic ratio of losartan, i.e., faster losartan metabolism.
341:
318:
1441:(ADRs) often result from unanticipated changes in CYP2C9 enzyme activity secondary to genetic polymorphisms. Especially for CYP2C9 substrates such as warfarin and phenytoin, diminished metabolic capacity because of genetic polymorphisms or drug-drug interactions can lead to toxicity at normal therapeutic doses. Information about how human genetic variation of CYP2C9 affects response to medications can be found in databases such PharmGKB, Clinical Pharmacogenetics Implementation Consortium (CPIC).
215:
240:
1448:(PharmVar) to the most commonly observed human gene variant. Other relevant variants are cataloged by PharmVar under consecutive numbers, which are written after an asterisk (star) character to form an allele label. The two most well-characterized variant alleles are CYP2C9*2 (NM_000771.3:c.430C>T, p.Arg144Cys, rs1799853) and CYP2C9*3 (NM_000771.3:c.1075A>C, p. Ile359Leu, rs1057910), causing reductions in enzyme activity of 30% and 80%, respectively.
606:
599:
592:
5937:
347:
246:
5922:
5907:
1394:, endothelial cell migration, endothelial cell proliferation, and the growth and metastasis of human breast and prostate cancer cell lines whereas EETs have stimulatory effects in each of these systems. Consumption of omega-3 fatty acid-rich diets dramatically raises the serum and tissue levels of EDPs and EEQs in animals as well as humans, and in humans is by far the most prominent change in the profile of
7530:
42:
2760:
expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen, and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
5527:
3818:
2765:
2737:
1457:
heterozygous state, i.e. just one of these alleles (*1/*2, *1/*3) are designated intermediate metabolizers (IM), and those carrying two of these alleles, i.e. homozygous (*2/*3, *2/*2 or *3/*3) – poor metabolizers (PM). As a result, the metabolic ratio – the ratio of unchanged drug to metabolite – is higher in PMs.
1543:
CYP2C9*13 is defined by a missense variant in exon 2 (NM_000771.3:c.269T>C, p. Leu90Pro, rs72558187). CYP2C9*13 prevalence is approximately 1% in the Asian population, but in
Caucasians this variant prevalence is almost zero. This variant is caused by a T269C mutation in the CYP2C9 gene which
1456:
On the basis of their ability to metabolize CYP2C9 substrates, individuals can be categorized by groups. The carriers of homozygous CYP2C9*1 variant, i.e. of the *1/*1 genotype, are designated extensive metabolizers (EM), or normal metabolizers. The carriers of the CYP2C9*2 or CYP2C9*3 alleles in a
1460:
A study of the ability to metabolize warfarin among the carriers of the most well-characterized CYP2C9 genotypes (*1, *2 and *3), expressed as a percentage of the mean dose in patients with wild-type alleles (*1/*1), concluded that the mean warfarin maintenance dose was 92% in *1/*2, 74% in *1/*3,
2759:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its
1544:
in turn results in the substitution of leucine at position-90 with proline (L90P) at the product enzyme protein. This residue is near the access point for substrates and the L90P mutation causes lower affinity and hence slower metabolism of several drugs that are metabolized CYP2C9 by such as
1536:
CYP2C9 variant alleles recommended as Tier 1 by the PGx
Working Group include CYP2C9 *2, *3, *5, *6, *8, and *11. This recommendation was based on their well-established functional effects on CYP2C9 activity and drug response availability of reference materials, and their appreciable allele
1337:
In vitro studies on human and animal cells and tissues and in vivo animal model studies indicate that certain EDPs and EEQs (16,17-EDPs, 19,20-EDPs, 17,18-EEQs have been most often examined) have actions which often oppose those of another product of CYP450 enzymes (e.g.
68:
4051:
Hatta FH, Teh LK, Helldén A, Hellgren KE, Roh HK, Salleh MZ, Aklillu E, Bertilsson L (July 2012). "Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes".
1552:. However, this variant is not included in the tier 1 recommendations of the PGx Working Group because of its very low multiethnic minor allele frequency and a lack of currently available reference materials. As of 2020 the evidence level for CYP2C9*13 in the
5368:
Yamaori S, Koeda K, Kushihara M, Hada Y, Yamamoto I, Watanabe K (1 January 2012). "Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity".
2541:-rich diets dramatically raises the serum and tissue levels of the EDP and EEQ metabolites of the omega-3 fatty acid, i.e. docosahexaenoic and eicosapentaenoic acids, in animals and humans and in humans is the most prominent change in the profile of
1532:
The
Association for Molecular Pathology Pharmacogenomics (PGx) Working Group in 2019 has recommended a minimum panel of variant alleles (Tier 1) and an extended panel of variant alleles (Tier 2) to be included in assays for CYP2C9 testing.
5151:
Tirkkonen T, Heikkilä P, Huupponen R, Laine K (October 2010). "Potential CYP2C9-mediated drug-drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide".
1182:
enzyme, which plays a significant role in the metabolism, by oxidation, of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes. The protein is mainly expressed in the
4637:
Abdullah
Alkattan & Eman Alsalameen (2021) Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment, Expert Opinion on Drug Metabolism & Toxicology,
2741:
3736:
Sullivan-Klose TH, Ghanayem BI, Bell DA, Zhang ZY, Kaminsky LS, Shenfield GM, Miners JO, Birkett DJ, Goldstein JA, The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism， Pharmacogenetics. 1996 Aug;
4841:
Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K (October 2001). "Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status".
5086:
3483:
Sullivan-Klose TH, Ghanayem BI, Bell DA, Zhang ZY, Kaminsky LS, Shenfield GM, Miners JO, Birkett DJ, Goldstein JA (August 1996). "The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism".
4016:
Dorado P, Gallego A, Peñas-LLedó E, Terán E, LLerena A (August 2014). "Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy
Ecuadorian volunteers".
4430:
693:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1163:. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the protein is encoded by the
2655:
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (April 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily".
3886:
Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L, Lindh J, Rane A, Wadelius M, Deloukas P (March 2009).
6615:
4565:
Guo Y, Zhang Y, Wang Y, Chen X, Si D, Zhong D, Fawcett JP, Zhou H (June 2005). "Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans".
5198:
He N, Zhang WQ, Shockley D, Edeki T (February 2002). "Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes".
4798:
Miyazawa M, Shindo M, Shimada T (May 2002). "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes".
4122:
Salsali M, Holt A, Baker GB (February 2004). "Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6".
4655:
Bland TM, Haining RL, Tracy TS, Callery PS (October 2005). "CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin".
5108:
Kudo T, Endo Y, Taguchi R, Yatsu M, Ito K (May 2015). "Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes".
4986:
4956:
354:
253:
7080:
3165:"Recommendations for Clinical CYP2C9 Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists"
5078:
3777:
4871:"Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems"
4165:
Nakajima M, Yoshida R, Shimada N, Yamazaki H, Yokoi T (August 2001). "Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate".
1476:
sequence, and also has reduced catalytic activity compared with the wild type (CYP2C9*1) for substrates other than warfarin. Its prevalence varies with race as:
3212:
GarcĂa-MartĂn E, MartĂnez C, Ladero JM, AgĂşndez JA (2006). "Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals".
2754:
2915:
Fleming I (October 2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease".
6664:
3101:
Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von
Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH (June 2014).
4543:
6836:
162:
3432:
Botton, Whirl-Carrillo, Tredici, Sangkuhl, Cavallari, AgĂşndez, Duconge J, Lee, Woodahl, Claudio-Campos, Daly, Klein, Pratt, Scott, Gaedigk (June 2020).
894:
3835:
Claudio-Campos K, Labastida A, Ramos A, Gaedigk A, Renta-Torres J, Padilla D, Rivera-Miranda G, Scott SA, Ruaño G, Cadilla CL, Duconge-Soler J (2017).
875:
6818:
6814:
5977:
5341:
Robertson P, DeCory HH, Madan A, Parkinson A (June 2000). "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil".
2529:, blood vessel formation, and pain perception; limited studies suggest but have not proven that these epoxides may function similarly in humans (see
6503:
2692:"Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1"
4422:
3969:"Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans"
1634:
7087:
6796:
6320:
1913:
4192:
Zhang JW, Liu Y, Li W, Hao DC, Yang L (July 2006). "Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes".
7550:
5936:
5886:
4387:
3771:
2637:
1939:
2619:
1310:(EEQs, primarily 17,18-EEQ and 14,15-EEQ isomers). Animal models and a limited number of human studies implicate these epoxides in reducing
7183:
6740:
6656:
5412:
Briguglio M, Hrelia S, Malaguti M, Serpe L, Canaparo R, Dell'Osso B, Galentino R, De
Michele S, Dina CZ, Porta M, Banfi G (December 2018).
5043:
Pan X, Tan N, Zeng G, Zhang Y, Jia R (October 2005). "Amentoflavone and its derivatives as novel natural inhibitors of human
Cathepsin B".
4690:
Patton AL, Seely KA, Yarbrough AL, Fantegrossi W, James LP, McCain KR, Fujiwara R, Prather PL, Moran JH, Radominska-Pandya A (April 2018).
2279:
4926:
4244:
Si D, Wang Y, Zhou YH, Guo Y, Wang J, Zhou H, Li ZS, Fawcett JP (March 2009). "Mechanism of CYP2C9 inhibition by flavones and flavonols".
4095:
Bourrié M, Meunier V, Berger Y, Fabre G (February 1999). "Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes".
340:
6981:
6680:
5742:
Palkimas MP, Skinner HM, Gandhi PJ, Gardner AJ (June 2003). "Polymorphism induced sensitivity to warfarin: a review of the literature".
5651:
Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily".
5008:
Kimura Y, Ito H, Ohnishi R, Hatano T (January 2010). "Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity".
1834:
1220:
5846:
5535:
3803:
3752:"Study of the Structural Pathology Caused by CYP2C9 Polymorphisms towards Flurbiprofen Metabolism Using Molecular Dynamics Simulation."
1090:
3668:
Topić E, Stefanović M, Samardzija M (January 2004). "Association between the CYP2C9 polymorphism and the drug metabolism phenotype".
3617:
Sychev DA, Shuev GN, Suleymanov SS, Ryzhikova KA, Mirzaev KB, Grishina EA, Snalina NE, Sozaeva ZA, Grabuzdov AM, Matsneva IA (2017).
1097:
317:
7249:
5563:
3945:
3544:
1565:
1553:
1445:
6720:
2875:
Westphal C, Konkel A, Schunck WH (November 2011). "CYP-eicosanoids – a new link between omega-3 fatty acids and cardiac disease?".
1653:
being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values, or 20–50% decrease in clearance.
5921:
5906:
1223:. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compounds such as serotonin and, owing to its
7059:
5713:
Xie HG, Prasad HC, Kim RB, Stein CM (November 2002). "CYP2C9 allelic variants: ethnic distribution and functional significance".
4616:
3298:
4978:
4948:
3255:
Rosemary J, Adithan C (January 2007). "The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance".
6857:
6698:
6577:
6276:
2606:
2585:
1999:
1616:
1612:
1434:
1363:
1359:
7043:
6850:
239:
214:
7405:
5852:
2602:
4391:
2782:
Rettie AE, Jones JP (2005). "Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics".
6754:
6724:
6684:
6672:
5970:
2019:
2009:
7520:
2581:
6908:
6822:
6810:
5831:
4741:"Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review"
3888:"A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose"
3163:
Pratt VM, Cavallari LH, Del
Tredici AL, Hachad H, Ji Y, Moyer AM, Scott SA, Whirl-Carrillo M, Weck KE (September 2019).
2517:
to various epoxyeicosatetraenoic acids (also termed EEQs). Animal model studies implicate these epoxides in regulating:
2029:
142:
5545:
133:, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, cytochrome P450 family 2 subfamily C member 9, Cytochrome P450 2C9, P450-2C9
6960:
6660:
6328:
1990:
1593:
1239:
353:
252:
5955:
3715:
3570:"Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing"
6843:
6782:
6778:
6766:
6762:
6758:
3758:. Communications in Computer and Information Science. Vol. 115. Berlin, Heidelberg: Springer. pp. 26–35.
2542:
2507:
1581:
1418:
1395:
1371:
1367:
1307:
1299:
1228:
346:
245:
7390:
3361:
1362:(20-HETE), principally in the areas of blood pressure regulation, blood vessel thrombosis, and cancer growth (see
7506:
7493:
7480:
7467:
7454:
7441:
7428:
7146:
7031:
6800:
5879:
2549:
and EEQs may be responsible for at least some of the beneficial effects ascribed to dietary omega-3 fatty acids.
1322:; stimulating blood vessel formation; and possessing a variety of actions on neural tissues including modulating
1195:. About 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as
7400:
5680:
Henderson RF (June 2001). "Species differences in the metabolism of olefins: implications for risk assessment".
5294:"Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes"
7555:
7354:
7297:
7215:
6953:
6900:
6895:
6750:
6601:
5998:
5963:
5579:
Goldstein JA, de Morais SM (December 1994). "Biochemistry and molecular biology of the human CYP2C subfamily".
4776:
4535:
2530:
2481:
2138:
1903:
1846:
1589:
1327:
939:
186:
150:
3967:
Hernandez W, Aquino-Michaels K, Drozda K, Patel S, Jeong Y, Takahashi H, Cavallari LH, Perera MA (June 2015).
3328:
3103:"Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway"
5465:"Resveratrol stereoselectively affected (±)warfarin pharmacokinetics and enhanced the anticoagulation effect"
3568:
Caudle KE, Rettie AE, Whirl-Carrillo M, Smith LH, Mintzer S, Lee MT, Klein TE, Callaghan JT (November 2014).
1647:
being one that causes at least a 2-fold increase in the plasma AUC values, or a 50–80% decrease in clearance.
65:
7302:
7002:
6875:
3837:"Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study"
2558:
2182:
920:
6829:
6774:
6770:
6736:
6668:
6250:
3383:
Botton MR, Lu X, Zhao G, Repnikova E, Seki Y, Gaedigk A, Schadt EE, Edelmann L, Scott SA (November 2019).
2339:
1623:
1577:
1438:
1414:
7323:
7242:
7066:
6572:
4530:
2546:
2522:
2514:
2329:
2124:
2054:
1893:
1375:
1315:
1303:
228:
7395:
1781:
7024:
6921:
6792:
6691:
6332:
5872:
5685:
5476:
3750:
Saikatikorn Y, Lertkiatmongkol P, Assawamakin A, Ruengjitchatchawalya M, Tongsima S (November 2010).
2503:
2345:
2068:
1955:
1883:
1842:
1638:
1295:
678:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
129:
7359:
7176:
6882:
6710:
5858:
1861:
1318:
and other insults to the heart; promoting the growth and metastasis of certain cancers; inhibiting
6524:
5414:"Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles"
1556:
database is limited, comparing to the tier 1 alleles, for which the evidence level is definitive.
7292:
6676:
5823:
5804:
5767:
5394:
5223:
5177:
5133:
4823:
4768:
4590:
4269:
4217:
4147:
4077:
3693:
3237:
2940:
2538:
174:
1170:. The gene is highly polymorphic, which affects the efficiency of the metabolism by the enzyme.
1054:
1028:
1007:
4918:
4692:"Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants"
3385:"Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles"
1540:
The following CYP2C9 alleles are recommended for inclusion in tier 2: CYP2C9*12, *13, and *15.
605:
598:
591:
5796:
5759:
5730:
5701:
5668:
5639:
5596:
5502:
5445:
5386:
5350:
5323:
5274:
5215:
5169:
5125:
5060:
5025:
4900:
4851:
4815:
4760:
4721:
4672:
4582:
4261:
4209:
4174:
4139:
4104:
4069:
4033:
3998:
3919:
3868:
3767:
3685:
3650:
3599:
3550:
3540:
3501:
3465:
3414:
3272:
3229:
3194:
3134:
3080:
3030:
2989:
2932:
2892:
2857:
2799:
2795:
2713:
2672:
1718:
122:
58:
6154:
3751:
3523:. Advances in Pharmacology (San Diego, Calif.). Vol. 83. Academic Press. pp. 3–32.
1355:
1351:
192:
7338:
7333:
7307:
7235:
6023:
5788:
5779:
Daly AK, Aithal GP (August 2003). "Genetic regulation of warfarin metabolism and response".
5751:
5722:
5693:
5660:
5629:
5621:
5588:
5492:
5484:
5435:
5425:
5378:
5313:
5305:
5264:
5254:
5207:
5161:
5117:
5052:
5017:
4890:
4882:
4881:(12). American Society for Pharmacology & Experimental Therapeutics (ASPET): 2056–2065.
4807:
4752:
4711:
4703:
4664:
4639:
4574:
4472:
4253:
4201:
4131:
4061:
4025:
3988:
3980:
3909:
3899:
3858:
3848:
3799:
3759:
3677:
3640:
3630:
3589:
3581:
3532:
3524:
3493:
3455:
3445:
3404:
3396:
3264:
3221:
3184:
3176:
3124:
3114:
3070:
3062:
3020:
2979:
2971:
2924:
2884:
2847:
2839:
2791:
2703:
2690:
Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T (September 1994).
2664:
2477:
2319:
2305:
2092:
1608:
1601:
1597:
1339:
1235:
433:
364:
308:
263:
170:
3055:"The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling"
2495:, linoleic acid 9,10-oxide, or leukotoxin) and 12,13-epoxy-octadecenoic acids (also termed
1437:(SNPs) have been reported to have functional evidence of altered enzyme activity. In fact,
7385:
7369:
7282:
7125:
5994:
5835:
2960:"Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer"
2205:
1192:
1179:
408:
5755:
4135:
3937:
3066:
2888:
1619:
of CYP2C9. Where classes of agents are listed, there may be exceptions within the class.
5689:
5480:
5269:
5242:
7534:
7423:
7364:
6433:
5634:
5609:
5497:
5464:
5440:
5413:
4895:
4870:
4716:
4691:
3993:
3968:
3914:
3887:
3863:
3836:
3645:
3618:
3594:
3569:
3460:
3433:
3409:
3384:
3189:
3164:
3129:
3102:
3075:
3054:
2984:
2959:
2852:
2827:
2492:
2275:
2144:
2114:
2088:
2074:
1406:
1374:
sections on activities and clinical significance). Such studies also indicate that the
5726:
5697:
5318:
5293:
5079:"Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers"
4869:
Lutz JD, VandenBrink BM, Babu KN, Nelson WL, Kunze KL, Isoherranen N (December 2013).
4608:
4423:"Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers"
3290:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
733:
728:
723:
718:
713:
708:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
7544:
7328:
7287:
7208:
7112:
7073:
6995:
6988:
6974:
6934:
6915:
6889:
5808:
5625:
5592:
5309:
5165:
3822:
3497:
2769:
2496:
2488:
2438:
2433:
2178:
2130:
2084:
2078:
2064:
2060:
1949:
1925:
1899:
1873:
1812:
1775:
1410:
1402:
1204:
634:
5771:
5398:
5243:"Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity"
5181:
5137:
4772:
4594:
4221:
4151:
3697:
3241:
2944:
2453:
CYP2C9 attacks various long-chain polyunsaturated fatty acids at their double (i.e.
154:
7277:
6731:
6705:
6609:
6595:
6588:
6494:
6474:
6467:
6450:
6392:
6375:
6368:
6361:
6354:
6347:
6315:
6308:
4827:
4081:
2526:
2518:
2406:
2400:
2325:
2254:
2193:
1929:
1838:
1801:
1797:
1549:
1391:
1323:
1319:
1311:
1243:
426:
205:
5430:
5227:
4643:
4477:
4460:
4273:
2975:
1386:
more potent than or equal in potency to the EETs in suppressing inflammation; and
5121:
4756:
3904:
3180:
2843:
178:
7501:
7436:
7272:
6301:
6257:
5382:
4383:
3763:
3528:
2751:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2642:
National Center for Biotechnology Information, U.S. National Library of Medicine
2624:
National Center for Biotechnology Information, U.S. National Library of Medicine
2534:
2410:
2377:
2349:
2335:
2240:
2230:
2210:
2120:
2025:
1995:
1974:
1919:
1889:
1822:
1817:
1787:
1714:
1331:
1231:, converting these fatty acids to a wide range of biologically active products.
1224:
1208:
7529:
5488:
4707:
3984:
3519:
Tornio A, Backman JT (2018). "Cytochrome P450 in Pharmacogenetics: An Update".
3268:
1564:
Not all clinically significant genetic variant alleles have been registered by
509:
5986:
5259:
5211:
5056:
5021:
4668:
4205:
4065:
3756:
International Conference on Computational Systems – Biology and Bioinformatics
2828:"Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism"
2423:
2396:
2381:
2353:
2315:
2309:
2295:
2289:
2285:
2260:
2134:
2110:
2050:
2035:
1980:
1945:
1909:
1879:
1869:
1852:
1749:
1734:
1729:
1684:
1585:
1545:
1473:
1465:
325:
222:
158:
5828:
3853:
7475:
7449:
7201:
6402:
5990:
5664:
5610:"Cytochrome P4502C9: an enzyme of major importance in human drug metabolism"
3025:
3008:
2270:
2250:
2225:
2200:
2188:
2161:
2156:
2015:
2005:
1984:
1935:
1827:
1807:
1771:
1759:
1754:
1739:
1724:
1710:
1694:
1679:
1216:
1200:
839:
569:
447:
392:
379:
291:
278:
166:
5800:
5763:
5734:
5705:
5506:
5449:
5390:
5354:
5327:
5278:
5219:
5173:
5129:
5064:
5029:
4904:
4886:
4855:
4819:
4764:
4725:
4676:
4586:
4578:
4265:
4257:
4213:
4178:
4143:
4073:
4037:
4002:
3923:
3872:
3689:
3654:
3603:
3554:
3469:
3418:
3276:
3233:
3198:
3138:
3084:
3034:
2993:
2936:
2896:
2861:
2803:
5672:
5643:
5600:
4108:
3681:
3585:
3505:
2928:
2832:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2717:
2676:
1137:
1132:
7158:
7118:
7105:
7050:
7017:
6967:
6945:
6940:
6926:
5792:
4811:
4461:"In silico metabolism studies of dietary flavonoids by CYP1A2 and CYP2C9"
3711:
3635:
2746:
2428:
2220:
2165:
2098:
1970:
1857:
1764:
1744:
1689:
1212:
1196:
1188:
1121:
965:
3536:
3119:
2668:
41:
17:
6627:
6554:
6544:
6534:
6517:
6507:
6499:
6487:
6483:
6479:
6460:
6412:
6385:
6340:
6336:
6324:
6215:
6210:
6205:
6180:
6175:
6159:
6079:
6074:
6054:
5840:
3400:
3353:
3225:
2708:
2691:
2462:
2458:
2359:
2214:
1965:
1960:
1469:
1343:
1160:
951:
906:
4029:
3619:"SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations"
3009:"Soluble epoxide hydrolase: A potential target for metabolic diseases"
1382:
more potent than EETs in decreasing hypertension and pain perception;
99:
95:
91:
87:
7488:
7258:
6294:
6290:
6280:
6266:
6262:
6230:
6225:
6220:
6200:
6195:
6190:
6185:
6149:
6144:
6139:
6119:
6114:
6109:
6104:
6099:
6094:
6089:
6084:
6064:
6059:
6049:
6044:
6028:
6018:
6013:
3450:
2470:
2466:
2454:
2371:
2367:
2363:
2264:
2234:
1791:
1347:
1157:
1105:
861:
4740:
3320:
7462:
6581:
6443:
6130:
1706:
1699:
1421:
in animal models and may contribute to these syndromes in humans.
1184:
4459:
Sousa MC, Braga RC, Cintra BA, de Oliveira V, Andrade CH (2013).
3821:
This article incorporates text from this source, which is in the
2768:
This article incorporates text from this source, which is in the
1302:(EDPs; primarily 19,20-epoxy-eicosapentaenoic acid isomers ) and
1294:-epoxy-5Z,8Z,11Z-eicosatetraenoic acids. It likewise metabolizes
824:
820:
6635:
5110:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
2461:
products that act as signaling molecules. It along with CYP2C8,
2299:
2244:
1413:(also termed isoleukotoxin); these linoleic acid epoxides cause
1167:
146:
7231:
5959:
5868:
2525:
and other insults to the heart, the growth of various cancers,
1633:
being one that causes at least a 5-fold increase in the plasma
614:
5864:
5520:
1604:
is the reported allosteric binding site of the CYP2C9 enzyme.
5463:
Huang TY, Yu CP, Hsieh YW, Lin SP, Hou YC (September 2020).
4384:"Drug Interactions: Cytochrome P450 Drug Interaction Table"
1600:. It was indicated that the noncompetitive binding site of
7227:
3053:
Wagner K, Vito S, Inceoglu B, Hammock BD (October 2014).
416:
4540:
Swedish environmental classification of pharmaceuticals
5945:: Crystal Structure of P4502C9 with Flurbiprofen bound
1659:
Selected inducers, inhibitors and substrates of CYP2C9
7518:
581:
7414:
7378:
7347:
7316:
7265:
7193:
7168:
7097:
6867:
6645:
6564:
6422:
6239:
6168:
6128:
6037:
6006:
5829:
SuperCYP: Database for Drug-Cytochrome-Interactions
5824:
PharmGKB: Annotated PGx Gene Information for CYP2C9
4696:
Biochemical and Biophysical Research Communications
3745:
3743:
2545:metabolites caused by dietary omega-3 fatty acids,
1398:metabolites caused by dietary omega-3 fatty acids.
1068:
1047:
1021:
1000:
4377:
4375:
4373:
4371:
4369:
4367:
4365:
4363:
4361:
4359:
4357:
4355:
4353:
4351:
4349:
4347:
4345:
4343:
4341:
4339:
4337:
4335:
4333:
4331:
4329:
4327:
4325:
4323:
4321:
4319:
4317:
4315:
4313:
4311:
4309:
4307:
4305:
4303:
2598:
2596:
2594:
2577:
2575:
2573:
1390:act oppositely from the EETs in that they inhibit
4301:
4299:
4297:
4295:
4293:
4291:
4289:
4287:
4285:
4283:
3802:. National Center for Biotechnology Information.
3348:
3346:
363:
262:
5241:Phucharoenrak P, Trachootham D (February 2024).
2499:, linoleic acid 12,13-oxide, or isoleukotoxin);
1622:Inhibitors of CYP2C9 can be classified by their
5193:
5191:
4536:"Facts for prescribers (Fakta för förskrivare)"
4239:
4237:
4235:
4233:
4231:
3158:
3156:
3154:
3152:
3150:
3148:
3096:
3094:
3048:
3046:
3044:
2910:
2908:
2906:
1784:(an inactive metabolite of clopidogrel prodrug)
1278:-epoxy-5Z,8Z,14Z-eicosatetraenoic acids; and 14
1203:, and other routinely prescribed drugs such as
2958:Zhang G, Kodani S, Hammock BD (January 2014).
2821:
2819:
2817:
2815:
2813:
2603:GRCm38: Ensembl release 89: ENSMUSG00000067231
2491:to 9,10-epoxy-octadecenoic acids (also termed
1482:Allele frequencies (%) of CYP2C9 polymorphism
7243:
5971:
5880:
4454:
4452:
4450:
4448:
4417:
4415:
4413:
4411:
4409:
2755:National Center for Biotechnology Information
1150:Cytochrome P450 family 2 subfamily C member 9
8:
2784:Annual Review of Pharmacology and Toxicology
2473:are the principle enzymes which metabolizes
1461:63% in *2/*3, 61% in *2/*2 and 34% in 3/*3.
1262:-epoxy-8Z,11Z,14Z-eicosatetraenoic acids; 11
5930:: STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
5915:: STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
2582:GRCh38: Ensembl release 89: ENSG00000138109
7250:
7236:
7228:
5978:
5964:
5956:
5887:
5873:
5865:
3670:Clinical Chemistry and Laboratory Medicine
3623:Pharmacogenomics and Personalized Medicine
3059:Prostaglandins & Other Lipid Mediators
2877:Prostaglandins & Other Lipid Mediators
2731:
2729:
2727:
1326:release and blocking pain perception (see
835:
800:long-chain fatty acid biosynthetic process
630:
404:
303:
200:
76:
5633:
5564:Learn how and when to remove this message
5496:
5439:
5429:
5317:
5292:Park JY, Kim KA, Kim SL (November 2003).
5268:
5258:
5200:European Journal of Clinical Pharmacology
4894:
4715:
4476:
4194:European Journal of Clinical Pharmacology
4054:European Journal of Clinical Pharmacology
3992:
3913:
3903:
3862:
3852:
3644:
3634:
3593:
3459:
3449:
3408:
3188:
3128:
3118:
3074:
3024:
2983:
2851:
2796:10.1146/annurev.pharmtox.45.120403.095821
2707:
1270:-epoxy-8Z,11Z,14Z-eicosatetraenoic and 11
5614:British Journal of Clinical Pharmacology
4979:"Edarbi – azilsartan kamedoxomil tablet"
4526:
4524:
4522:
4520:
4518:
4516:
4514:
4512:
4510:
4508:
1656:
1478:
1433:gene is highly polymorphic. At least 20
1405:to the potentially very toxic products,
1286:-epoxy-5Z,8Z,11Z-eicosatetraenoic and 14
1254:-epoxy-8Z,11Z,14Z-eicosatetraenoic and 5
724:intracellular membrane-bounded organelle
7525:
5902:
4919:"Verapamil: Drug information. Lexicomp"
4506:
4504:
4502:
4500:
4498:
4496:
4494:
4492:
4490:
4488:
2569:
5744:Journal of Thrombosis and Thrombolysis
3574:Clinical Pharmacology and Therapeutics
3438:Clinical Pharmacology and Therapeutics
3007:He J, Wang C, Zhu Y, Ai D (May 2016).
2696:The Japanese Journal of Human Genetics
1444:The label CYP2C9*1 is assigned by the
31:
5298:Antimicrobial Agents and Chemotherapy
4739:Stout SM, Cimino NM (February 2014).
4388:Indiana University School of Medicine
3948:from the original on 8 September 2015
3780:from the original on 24 February 2024
3754:. In Chan JH, Ong YS, Cho SB (eds.).
770:monocarboxylic acid metabolic process
653:arachidonic acid epoxygenase activity
368:
329:
324:
267:
226:
221:
7:
5371:Drug Metabolism and Pharmacokinetics
5089:from the original on 4 November 2020
5045:Bioorganic & Medicinal Chemistry
4989:from the original on 7 February 2019
4959:from the original on 7 February 2019
4929:from the original on 13 January 2019
4394:from the original on 10 October 2007
3806:from the original on 20 October 2020
3718:from the original on 13 January 2010
3169:The Journal of Molecular Diagnostics
3067:10.1016/j.prostaglandins.2014.09.001
2889:10.1016/j.prostaglandins.2011.09.001
1537:frequencies in major ethnic groups.
1221:nonsteroidal anti-inflammatory drugs
5608:Miners JO, Birkett DJ (June 1998).
4779:from the original on 6 October 2022
4124:Cellular and Molecular Neurobiology
3331:from the original on 3 October 2022
3301:from the original on 3 October 2022
1835:angiotensin II receptor antagonists
5756:10.1023/B:THRO.0000011376.12309.af
4433:from the original on 23 April 2019
4136:10.1023/B:CEMN.0000012725.31108.4a
1234:In particular, CYP2C9 metabolizes
1065:
1044:
1018:
997:
975:
956:
930:
911:
885:
866:
586:
504:
442:
421:
25:
4619:from the original on 1 April 2016
4546:from the original on 11 June 2002
4427:U.S. Food and Drug Administration
3364:from the original on 17 July 2020
3214:Molecular Diagnosis & Therapy
2826:Spector AA, Kim HY (April 2015).
1607:Following is a table of selected
1446:Pharmacogene Variation Consortium
7528:
5935:
5920:
5905:
5626:10.1046/j.1365-2125.1998.00721.x
5593:10.1097/00008571-199412000-00001
5525:
5310:10.1128/AAC.47.11.3464-3469.2003
5166:10.1111/j.1365-2796.2010.02257.x
3816:
3498:10.1097/00008571-199608000-00007
2763:
2740: This article incorporates
2735:
760:cellular amide metabolic process
604:
597:
590:
352:
345:
339:
316:
251:
244:
238:
213:
40:
5682:Chemico-Biological Interactions
5343:Drug Metabolism and Disposition
4875:Drug Metabolism and Disposition
4844:Drug Metabolism and Disposition
4800:Drug Metabolism and Disposition
4567:Drug Metabolism and Disposition
4246:Drug Metabolism and Disposition
4167:Drug Metabolism and Disposition
4097:Drug Metabolism and Disposition
2000:leukotriene receptor antagonist
1637:, or more than 80% decrease in
1435:single nucleotide polymorphisms
1364:20-Hydroxyeicosatetraenoic acid
1360:20-Hydroxyeicosatetraenoic acid
785:monoterpenoid metabolic process
5715:Advanced Drug Delivery Reviews
1576:Most inhibitors of CYP2C9 are
1528:Test panels of variant alleles
805:organic acid metabolic process
780:omega-hydroxylase P450 pathway
714:endoplasmic reticulum membrane
615:More reference expression data
570:More reference expression data
1:
5781:Seminars in Vascular Medicine
5727:10.1016/S0169-409X(02)00076-5
5698:10.1016/S0009-2797(01)00170-3
5548:and help improve the section.
5431:10.3390/pharmaceutics10040277
4644:10.1080/17425255.2021.1925249
4478:10.1016/j.foodres.2012.09.027
3800:"rs72558187 allele frequency"
3434:"PharmVar GeneFocus: CYP2C19"
3257:Current Clinical Pharmacology
2976:10.1016/j.plipres.2013.11.003
2020:moderate sensitive substrates
2010:moderate sensitive substrates
1409:(also termed leukotoxin) and
337:
236:
7551:Genes on human chromosome 10
5841:PharmVar Database for CYP2C9
5154:Journal of Internal Medicine
5122:10.3109/00498254.2014.990948
5010:Food and Chemical Toxicology
4757:10.3109/03602532.2013.849268
4609:"ketoprofen | C16H14O3"
3905:10.1371/journal.pgen.1000433
3712:"CYP2C9 allele nomenclature"
3181:10.1016/j.jmoldx.2019.04.003
2844:10.1016/j.bbalip.2014.07.020
2537:). Since the consumption of
2030:Moderate sensitive substrate
790:xenobiotic metabolic process
663:steroid hydroxylase activity
5383:10.2133/dmpk.DMPK-11-RG-107
4465:Food Research International
3764:10.1007/978-3-642-16750-8_3
3529:10.1016/bs.apha.2018.04.007
2543:polyunsaturated fatty acids
2508:epoxydocosapentaenoic acids
2038:(Minor substrate of CYP2C9)
1991:polyunsaturated fatty acids
1594:medroxyprogesterone acetate
1401:CYP2C9 may also metabolize
1396:polyunsaturated fatty acids
1308:epoxyeicosatetraenoic acids
1300:epoxydocosapentaenoic acids
1240:eicosatrienoic acid epoxide
1229:polyunsaturated fatty acids
7572:
5857:gene details page in the
5489:10.1038/s41598-020-72694-0
4708:10.1016/j.bbrc.2018.03.028
3985:10.1016/j.trsl.2014.11.006
3269:10.2174/157488407779422302
2964:Progress in Lipid Research
1419:acute respiratory distress
1372:epoxydocosapentaenoic acid
1368:epoxyeicosatetraenoic acid
810:estrogen metabolic process
7406:Michaelis–Menten kinetics
5900:
5260:10.3390/molecules29030713
5212:10.1007/s00228-001-0399-0
5057:10.1016/j.bmc.2005.05.071
5022:10.1016/j.fct.2009.10.041
4669:10.1016/j.bcp.2005.07.007
4206:10.1007/s00228-006-0128-9
4066:10.1007/s00228-012-1210-0
3841:Frontiers in Pharmacology
3107:Journal of Lipid Research
2638:"Mouse PubMed Reference:"
2620:"Human PubMed Reference:"
2482:epoxyeicosatrienoic acids
1582:Noncompetitive inhibitors
1481:
1136:
1131:
1127:
1120:
1104:
1085:
1072:
1051:
1040:
1025:
1004:
993:
982:
978:
963:
959:
950:
937:
933:
918:
914:
905:
892:
888:
873:
869:
860:
845:
838:
834:
818:
750:steroid metabolic process
668:caffeine oxidase activity
633:
629:
612:
589:
580:
567:
556:quadriceps femoris muscle
516:
507:
454:
445:
415:
407:
403:
386:
373:
336:
315:
306:
302:
285:
272:
235:
212:
203:
199:
190:
185:
140:
137:
127:
120:
115:
84:
79:
62:
57:
52:
48:
39:
34:
7298:Diffusion-limited enzyme
4657:Biochemical Pharmacology
3854:10.3389/fphar.2017.00347
3321:"CYP2C9 CPIC guidelines"
2531:Epoxyeicosatrienoic acid
2510:(also termed EDPs); and
2139:antiprotozoal medication
1904:tricyclic antidepressant
1590:phenethyl isothiocyanate
1328:epoxyeicosatrienoic acid
1098:Chr 19: 39.05 – 39.08 Mb
1091:Chr 10: 94.94 – 94.99 Mb
765:epoxygenase P450 pathway
5834:3 November 2011 at the
5665:10.1080/004982598238868
4745:Drug Metabolism Reviews
3026:10.1111/1753-0407.12358
2917:Pharmacological Reviews
2559:Cytochrome P450 oxidase
2356:(cannabis constituents)
2183:H1-receptor antagonists
775:oxidative demethylation
683:oxidoreductase activity
486:epithelium of esophagus
4887:10.1124/dmd.113.052639
4579:10.1124/dmd.105.003616
4258:10.1124/dmd.108.023416
3973:Translational Research
2742:public domain material
2547:eicosapentaenoic acids
2340:leukotriene antagonist
1578:competitive inhibitors
1472:(I359L) change in the
1452:Metabolizer phenotypes
1439:adverse drug reactions
1415:multiple organ failure
1376:eicosapentaenoic acids
795:urea metabolic process
688:monooxygenase activity
466:pancreatic ductal cell
63:Human UniProt search:
7391:Eadie–Hofstee diagram
7324:Allosteric regulation
4531:FASS (drug formulary)
4382:Flockhart DA (2007).
3682:10.1515/CCLM.2004.014
3586:10.1038/clpt.2014.159
2929:10.1124/pr.113.007781
2523:myocardial infarction
2515:eicosapentaenoic acid
1464:CYP2C9*3 reflects an
1316:myocardial infarction
1314:; protecting against
1304:eicosapentaenoic acid
729:endoplasmic reticulum
331:Chromosome 19 (mouse)
229:Chromosome 10 (human)
7401:Lineweaver–Burk plot
5851:genome location and
5793:10.1055/s-2003-44458
4949:"Candesartan Tablet"
4812:10.1124/dmd.30.5.602
3636:10.2147/PGPM.S129665
2504:docosahexaenoic acid
2484:(also termed EETs);
2449:Epoxygenase activity
2346:Tetrahydrocannabinol
1884:erectile dysfunction
1843:diabetic nephropathy
1296:docosahexaenoic acid
1178:CYP2C9 is a crucial
80:List of PDB id codes
53:Available structures
5859:UCSC Genome Browser
5690:2001CBI...135...53H
5481:2020NatSR..1015910H
4985:. 25 January 2018.
3120:10.1194/jlr.M047357
3013:Journal of Diabetes
2669:10.1021/bi00227a012
2173:Unspecified potency
1862:sensitive substrate
1661:
1584:of CYP2C9 include
1560:Additional variants
552:islet of Langerhans
482:gingival epithelium
458:right lobe of liver
7360:Enzyme superfamily
7293:Enzyme promiscuity
5684:. 135–136: 53–64.
5469:Scientific Reports
3401:10.1002/humu.23855
3226:10.1007/BF03256440
2709:10.1007/BF01874052
2539:omega-3 fatty acid
1657:
1227:activity, various
940:ENSMUSG00000067231
743:Biological process
709:organelle membrane
702:Cellular component
641:Molecular function
179:CYP2C9 - orthologs
7516:
7515:
7225:
7224:
5953:
5952:
5721:(10): 1257–1270.
5659:(12): 1129–1165.
5574:
5573:
5566:
5304:(11): 3464–3469.
5051:(20): 5819–5825.
4850:(10): 1284–1289.
4030:10.2217/pgs.14.85
4024:(11): 1417–1421.
3773:978-3-642-16749-2
3061:. 113–115: 2–12.
2757:. 29 March 2021.
2663:(13): 3247–3255.
2446:
2445:
1782:2-oxo-clopidogrel
1719:anti-inflammatory
1525:
1524:
1489:African-American
1238:to the following
1147:
1146:
1143:
1142:
1116:
1115:
1081:
1080:
1062:
1061:
1036:
1035:
1015:
1014:
989:
988:
972:
971:
946:
945:
927:
926:
901:
900:
882:
881:
830:
829:
658:metal ion binding
625:
624:
621:
620:
576:
575:
563:
562:
501:
500:
399:
398:
298:
297:
111:
110:
107:
106:
16:(Redirected from
7563:
7533:
7532:
7524:
7396:Hanes–Woolf plot
7339:Enzyme activator
7334:Enzyme inhibitor
7308:Enzyme catalysis
7252:
7245:
7238:
7229:
5997:(Most belong to
5980:
5973:
5966:
5957:
5939:
5924:
5909:
5889:
5882:
5875:
5866:
5812:
5775:
5738:
5709:
5676:
5647:
5637:
5604:
5581:Pharmacogenetics
5569:
5562:
5558:
5555:
5549:
5544:Please read the
5540:may need cleanup
5529:
5528:
5521:
5511:
5510:
5500:
5460:
5454:
5453:
5443:
5433:
5409:
5403:
5402:
5365:
5359:
5358:
5338:
5332:
5331:
5321:
5289:
5283:
5282:
5272:
5262:
5238:
5232:
5231:
5195:
5186:
5185:
5148:
5142:
5141:
5105:
5099:
5098:
5096:
5094:
5075:
5069:
5068:
5040:
5034:
5033:
5005:
4999:
4998:
4996:
4994:
4975:
4969:
4968:
4966:
4964:
4955:. 27 June 2017.
4945:
4939:
4938:
4936:
4934:
4915:
4909:
4908:
4898:
4866:
4860:
4859:
4838:
4832:
4831:
4795:
4789:
4788:
4786:
4784:
4736:
4730:
4729:
4719:
4687:
4681:
4680:
4663:(7): 1096–1103.
4652:
4646:
4635:
4629:
4628:
4626:
4624:
4605:
4599:
4598:
4562:
4556:
4555:
4553:
4551:
4528:
4483:
4482:
4480:
4456:
4443:
4442:
4440:
4438:
4419:
4404:
4403:
4401:
4399:
4379:
4278:
4277:
4241:
4226:
4225:
4189:
4183:
4182:
4173:(8): 1110–1113.
4162:
4156:
4155:
4119:
4113:
4112:
4092:
4086:
4085:
4060:(7): 1033–1042.
4048:
4042:
4041:
4018:Pharmacogenomics
4013:
4007:
4006:
3996:
3964:
3958:
3957:
3955:
3953:
3934:
3928:
3927:
3917:
3907:
3883:
3877:
3876:
3866:
3856:
3832:
3826:
3820:
3819:
3815:
3813:
3811:
3796:
3790:
3789:
3787:
3785:
3747:
3738:
3734:
3728:
3727:
3725:
3723:
3708:
3702:
3701:
3665:
3659:
3658:
3648:
3638:
3614:
3608:
3607:
3597:
3565:
3559:
3558:
3521:Pharmacogenetics
3516:
3510:
3509:
3486:Pharmacogenetics
3480:
3474:
3473:
3463:
3453:
3451:10.1002/cpt.1973
3429:
3423:
3422:
3412:
3380:
3374:
3373:
3371:
3369:
3358:www.pharmvar.org
3350:
3341:
3340:
3338:
3336:
3317:
3311:
3310:
3308:
3306:
3287:
3281:
3280:
3252:
3246:
3245:
3209:
3203:
3202:
3192:
3160:
3143:
3142:
3132:
3122:
3113:(6): 1150–1164.
3098:
3089:
3088:
3078:
3050:
3039:
3038:
3028:
3004:
2998:
2997:
2987:
2955:
2949:
2948:
2923:(4): 1106–1140.
2912:
2901:
2900:
2872:
2866:
2865:
2855:
2823:
2808:
2807:
2779:
2773:
2767:
2766:
2762:
2739:
2738:
2733:
2722:
2721:
2711:
2687:
2681:
2680:
2652:
2646:
2645:
2634:
2628:
2627:
2616:
2610:
2600:
2589:
2579:
2478:arachidonic acid
2457:) bonds to form
2320:chemotherapeutic
2306:sulfamethoxazole
2093:mood-stabilizing
2063:(constituent of
1662:
1602:6-hydroxyflavone
1598:6-hydroxyflavone
1479:
1425:Pharmacogenomics
1236:arachidonic acid
1129:
1128:
1100:
1093:
1076:
1066:
1057:
1045:
1041:RefSeq (protein)
1031:
1019:
1010:
998:
976:
957:
931:
912:
886:
867:
836:
755:lipid metabolism
648:iron ion binding
631:
617:
608:
601:
594:
587:
572:
512:
510:Top expressed in
505:
450:
448:Top expressed in
443:
422:
405:
395:
382:
371:
356:
349:
343:
332:
320:
304:
294:
281:
270:
255:
248:
242:
231:
217:
201:
195:
181:
132:
125:
102:
77:
71:
50:
49:
44:
32:
21:
7571:
7570:
7566:
7565:
7564:
7562:
7561:
7560:
7556:Cytochrome P450
7541:
7540:
7539:
7527:
7519:
7517:
7512:
7424:Oxidoreductases
7410:
7386:Enzyme kinetics
7374:
7370:List of enzymes
7343:
7312:
7283:Catalytic triad
7261:
7256:
7226:
7221:
7189:
7164:
7126:Halloween genes
7093:
6863:
6641:
6560:
6418:
6235:
6164:
6124:
6033:
6002:
5995:cytochrome P450
5984:
5954:
5949:
5946:
5940:
5931:
5925:
5916:
5910:
5896:
5893:
5836:Wayback Machine
5820:
5815:
5778:
5741:
5712:
5679:
5650:
5607:
5578:
5570:
5559:
5553:
5550:
5543:
5536:Further reading
5530:
5526:
5519:
5517:Further reading
5514:
5462:
5461:
5457:
5411:
5410:
5406:
5367:
5366:
5362:
5340:
5339:
5335:
5291:
5290:
5286:
5240:
5239:
5235:
5206:(12): 847–851.
5197:
5196:
5189:
5150:
5149:
5145:
5107:
5106:
5102:
5092:
5090:
5085:. 26 May 2021.
5077:
5076:
5072:
5042:
5041:
5037:
5007:
5006:
5002:
4992:
4990:
4977:
4976:
4972:
4962:
4960:
4947:
4946:
4942:
4932:
4930:
4917:
4916:
4912:
4868:
4867:
4863:
4840:
4839:
4835:
4797:
4796:
4792:
4782:
4780:
4738:
4737:
4733:
4689:
4688:
4684:
4654:
4653:
4649:
4636:
4632:
4622:
4620:
4607:
4606:
4602:
4564:
4563:
4559:
4549:
4547:
4534:
4529:
4486:
4458:
4457:
4446:
4436:
4434:
4421:
4420:
4407:
4397:
4395:
4381:
4380:
4281:
4243:
4242:
4229:
4191:
4190:
4186:
4164:
4163:
4159:
4121:
4120:
4116:
4094:
4093:
4089:
4050:
4049:
4045:
4015:
4014:
4010:
3966:
3965:
3961:
3951:
3949:
3936:
3935:
3931:
3898:(3): e1000433.
3885:
3884:
3880:
3834:
3833:
3829:
3817:
3809:
3807:
3798:
3797:
3793:
3783:
3781:
3774:
3749:
3748:
3741:
3735:
3731:
3721:
3719:
3710:
3709:
3705:
3667:
3666:
3662:
3616:
3615:
3611:
3567:
3566:
3562:
3547:
3518:
3517:
3513:
3482:
3481:
3477:
3431:
3430:
3426:
3395:(11): e37–e51.
3382:
3381:
3377:
3367:
3365:
3352:
3351:
3344:
3334:
3332:
3319:
3318:
3314:
3304:
3302:
3289:
3288:
3284:
3254:
3253:
3249:
3211:
3210:
3206:
3162:
3161:
3146:
3100:
3099:
3092:
3052:
3051:
3042:
3006:
3005:
3001:
2957:
2956:
2952:
2914:
2913:
2904:
2883:(1–4): 99–108.
2874:
2873:
2869:
2825:
2824:
2811:
2781:
2780:
2776:
2764:
2745:
2736:
2734:
2725:
2689:
2688:
2684:
2654:
2653:
2649:
2636:
2635:
2631:
2618:
2617:
2613:
2601:
2592:
2580:
2571:
2567:
2555:
2469:, and possibly
2451:
2380:(a plant-based
2206:chloramphenicol
2164:(a plant-based
2069:St. John's Wort
1916:antidepressant)
1574:
1562:
1530:
1454:
1427:
1193:small intestine
1180:cytochrome P450
1176:
1138:View/Edit Mouse
1133:View/Edit Human
1096:
1089:
1086:Location (UCSC)
1074:
1053:
1027:
1006:
921:ENSG00000138109
814:
738:
697:
613:
603:
602:
596:
595:
568:
559:
554:
550:
546:
542:
538:
534:
530:
526:
522:
508:
497:
492:
490:body of stomach
488:
484:
480:
476:
472:
470:mucosa of ileum
468:
464:
460:
446:
390:
377:
369:
359:
358:
357:
350:
330:
307:Gene location (
289:
276:
268:
258:
257:
256:
249:
227:
204:Gene location (
191:
141:
128:
121:
86:
64:
28:
23:
22:
15:
12:
11:
5:
7569:
7567:
7559:
7558:
7553:
7543:
7542:
7538:
7537:
7514:
7513:
7511:
7510:
7497:
7484:
7471:
7458:
7445:
7432:
7418:
7416:
7412:
7411:
7409:
7408:
7403:
7398:
7393:
7388:
7382:
7380:
7376:
7375:
7373:
7372:
7367:
7362:
7357:
7351:
7349:
7348:Classification
7345:
7344:
7342:
7341:
7336:
7331:
7326:
7320:
7318:
7314:
7313:
7311:
7310:
7305:
7300:
7295:
7290:
7285:
7280:
7275:
7269:
7267:
7263:
7262:
7257:
7255:
7254:
7247:
7240:
7232:
7223:
7222:
7220:
7219:
7212:
7205:
7197:
7195:
7191:
7190:
7188:
7187:
7180:
7172:
7170:
7166:
7165:
7163:
7162:
7155:
7123:
7122:
7121:
7109:
7101:
7099:
7095:
7094:
7092:
7091:
7084:
7077:
7070:
7063:
7056:
7055:
7054:
7047:
7035:
7028:
7021:
7014:
7013:
7012:
7009:
6999:
6992:
6985:
6978:
6971:
6964:
6957:
6950:
6949:
6948:
6943:
6931:
6930:
6929:
6924:
6912:
6905:
6904:
6903:
6898:
6886:
6879:
6871:
6869:
6865:
6864:
6862:
6861:
6854:
6847:
6840:
6833:
6826:
6804:
6786:
6744:
6728:
6714:
6702:
6695:
6688:
6649:
6647:
6643:
6642:
6640:
6639:
6632:
6631:
6630:
6620:
6619:
6618:
6606:
6605:
6604:
6592:
6585:
6568:
6566:
6562:
6561:
6559:
6558:
6548:
6538:
6528:
6521:
6511:
6491:
6471:
6464:
6454:
6447:
6437:
6426:
6424:
6420:
6419:
6417:
6416:
6406:
6396:
6389:
6379:
6372:
6365:
6358:
6351:
6344:
6312:
6305:
6298:
6284:
6270:
6254:
6243:
6241:
6237:
6236:
6234:
6233:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6178:
6172:
6170:
6166:
6165:
6163:
6162:
6157:
6152:
6147:
6142:
6136:
6134:
6126:
6125:
6123:
6122:
6117:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6062:
6057:
6052:
6047:
6041:
6039:
6035:
6034:
6032:
6031:
6026:
6021:
6016:
6010:
6008:
6004:
6003:
5985:
5983:
5982:
5975:
5968:
5960:
5951:
5950:
5948:
5947:
5941:
5934:
5932:
5926:
5919:
5917:
5911:
5904:
5901:
5898:
5897:
5894:
5892:
5891:
5884:
5877:
5869:
5863:
5862:
5843:
5838:
5826:
5819:
5818:External links
5816:
5814:
5813:
5787:(3): 231–238.
5776:
5750:(3): 205–212.
5739:
5710:
5677:
5648:
5620:(6): 525–538.
5605:
5587:(6): 285–299.
5575:
5572:
5571:
5533:
5531:
5524:
5518:
5515:
5513:
5512:
5455:
5404:
5377:(3): 294–300.
5360:
5349:(6): 664–671.
5333:
5284:
5233:
5187:
5160:(4): 359–366.
5143:
5116:(5): 413–419.
5100:
5070:
5035:
5016:(1): 429–435.
5000:
4970:
4940:
4910:
4861:
4833:
4806:(5): 602–607.
4790:
4731:
4702:(3): 597–602.
4682:
4647:
4630:
4600:
4573:(6): 749–753.
4557:
4542:(in Swedish).
4484:
4444:
4405:
4279:
4252:(3): 629–634.
4227:
4200:(7): 497–502.
4184:
4157:
4114:
4103:(2): 288–296.
4087:
4043:
4008:
3979:(6): 651–657.
3959:
3929:
3878:
3827:
3791:
3772:
3739:
3729:
3703:
3660:
3609:
3580:(5): 542–548.
3560:
3545:
3511:
3492:(4): 341–349.
3475:
3444:(2): 352–366.
3424:
3389:Human Mutation
3375:
3342:
3312:
3282:
3247:
3204:
3175:(5): 746–755.
3144:
3090:
3040:
3019:(3): 305–313.
2999:
2950:
2902:
2867:
2838:(4): 356–365.
2809:
2774:
2723:
2702:(3): 337–343.
2682:
2647:
2629:
2611:
2590:
2568:
2566:
2563:
2562:
2561:
2554:
2551:
2493:coronaric acid
2450:
2447:
2444:
2443:
2442:
2441:
2436:
2431:
2426:
2415:
2414:
2404:
2387:
2386:
2385:
2375:
2357:
2343:
2333:
2323:
2313:
2303:
2293:
2283:
2276:phenylbutazone
2273:
2268:
2258:
2248:
2238:
2228:
2223:
2218:
2208:
2203:
2198:
2197:
2196:
2191:
2179:antihistamines
2170:
2169:
2159:
2148:
2147:
2145:phenylbutazone
2142:
2128:
2118:
2115:antiarrhythmic
2102:
2101:
2096:
2089:anticonvulsant
2082:
2075:sulfaphenazole
2072:
2058:
2041:
2040:
2039:
2033:
2023:
2013:
2003:
1993:
1988:
1978:
1968:
1963:
1958:
1953:
1943:
1933:
1923:
1922:(antidiabetic)
1917:
1907:
1897:
1887:
1877:
1867:
1866:
1865:
1855:
1832:
1831:
1830:
1825:
1820:
1815:
1810:
1795:
1785:
1779:
1769:
1768:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1704:
1703:
1702:
1697:
1692:
1687:
1673:
1672:
1669:
1666:
1655:
1654:
1648:
1642:
1573:
1570:
1561:
1558:
1529:
1526:
1523:
1522:
1519:
1516:
1513:
1510:
1507:
1503:
1502:
1499:
1496:
1493:
1492:Black-African
1490:
1487:
1484:
1483:
1453:
1450:
1426:
1423:
1407:coronaric acid
1378:and EEQs are:
1175:
1172:
1145:
1144:
1141:
1140:
1135:
1125:
1124:
1118:
1117:
1114:
1113:
1111:
1109:
1102:
1101:
1094:
1087:
1083:
1082:
1079:
1078:
1070:
1069:
1063:
1060:
1059:
1049:
1048:
1042:
1038:
1037:
1034:
1033:
1023:
1022:
1016:
1013:
1012:
1002:
1001:
995:
991:
990:
987:
986:
980:
979:
973:
970:
969:
961:
960:
954:
948:
947:
944:
943:
935:
934:
928:
925:
924:
916:
915:
909:
903:
902:
899:
898:
890:
889:
883:
880:
879:
871:
870:
864:
858:
857:
852:
847:
843:
842:
832:
831:
828:
827:
816:
815:
813:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
746:
744:
740:
739:
737:
736:
731:
726:
721:
716:
711:
705:
703:
699:
698:
696:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
644:
642:
638:
637:
627:
626:
623:
622:
619:
618:
610:
609:
584:
578:
577:
574:
573:
565:
564:
561:
560:
558:
557:
553:
549:
545:
541:
537:
533:
529:
525:
521:
517:
514:
513:
502:
499:
498:
496:
495:
494:gastric mucosa
491:
487:
483:
479:
475:
471:
467:
463:
462:jejunal mucosa
459:
455:
452:
451:
439:
438:
430:
419:
413:
412:
409:RNA expression
401:
400:
397:
396:
388:
384:
383:
375:
372:
367:
361:
360:
351:
344:
338:
334:
333:
328:
322:
321:
313:
312:
300:
299:
296:
295:
287:
283:
282:
274:
271:
266:
260:
259:
250:
243:
237:
233:
232:
225:
219:
218:
210:
209:
197:
196:
189:
183:
182:
139:
135:
134:
126:
118:
117:
113:
112:
109:
108:
105:
104:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
27:Enzyme protein
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7568:
7557:
7554:
7552:
7549:
7548:
7546:
7536:
7531:
7526:
7522:
7508:
7504:
7503:
7498:
7495:
7491:
7490:
7485:
7482:
7478:
7477:
7472:
7469:
7465:
7464:
7459:
7456:
7452:
7451:
7446:
7443:
7439:
7438:
7433:
7430:
7426:
7425:
7420:
7419:
7417:
7413:
7407:
7404:
7402:
7399:
7397:
7394:
7392:
7389:
7387:
7384:
7383:
7381:
7377:
7371:
7368:
7366:
7365:Enzyme family
7363:
7361:
7358:
7356:
7353:
7352:
7350:
7346:
7340:
7337:
7335:
7332:
7330:
7329:Cooperativity
7327:
7325:
7322:
7321:
7319:
7315:
7309:
7306:
7304:
7301:
7299:
7296:
7294:
7291:
7289:
7288:Oxyanion hole
7286:
7284:
7281:
7279:
7276:
7274:
7271:
7270:
7268:
7264:
7260:
7253:
7248:
7246:
7241:
7239:
7234:
7233:
7230:
7218:
7217:
7213:
7211:
7210:
7206:
7204:
7203:
7199:
7198:
7196:
7192:
7186:
7185:
7181:
7179:
7178:
7174:
7173:
7171:
7167:
7161:
7160:
7156:
7153:
7149:
7148:
7143:
7139:
7135:
7131:
7127:
7124:
7120:
7117:
7116:
7115:
7114:
7110:
7108:
7107:
7103:
7102:
7100:
7096:
7090:
7089:
7085:
7083:
7082:
7078:
7076:
7075:
7071:
7069:
7068:
7064:
7062:
7061:
7057:
7053:
7052:
7048:
7046:
7045:
7041:
7040:
7039:
7036:
7034:
7033:
7029:
7027:
7026:
7022:
7020:
7019:
7015:
7010:
7007:
7006:
7005:
7004:
7000:
6998:
6997:
6993:
6991:
6990:
6986:
6984:
6983:
6979:
6977:
6976:
6972:
6970:
6969:
6965:
6963:
6962:
6958:
6956:
6955:
6951:
6947:
6944:
6942:
6939:
6938:
6937:
6936:
6932:
6928:
6925:
6923:
6920:
6919:
6918:
6917:
6913:
6911:
6910:
6906:
6902:
6899:
6897:
6894:
6893:
6892:
6891:
6887:
6885:
6884:
6880:
6878:
6877:
6873:
6872:
6870:
6866:
6860:
6859:
6855:
6853:
6852:
6848:
6846:
6845:
6841:
6839:
6838:
6834:
6832:
6831:
6827:
6824:
6820:
6816:
6812:
6808:
6805:
6802:
6798:
6794:
6790:
6787:
6784:
6780:
6776:
6772:
6768:
6764:
6760:
6756:
6752:
6748:
6745:
6742:
6738:
6734:
6733:
6729:
6726:
6722:
6718:
6715:
6712:
6708:
6707:
6703:
6701:
6700:
6696:
6694:
6693:
6689:
6686:
6682:
6678:
6674:
6670:
6666:
6662:
6658:
6654:
6651:
6650:
6648:
6644:
6638:
6637:
6633:
6629:
6626:
6625:
6624:
6621:
6617:
6614:
6613:
6612:
6611:
6607:
6603:
6600:
6599:
6598:
6597:
6593:
6591:
6590:
6586:
6583:
6579:
6575:
6574:
6570:
6569:
6567:
6563:
6556:
6552:
6549:
6546:
6542:
6539:
6536:
6532:
6529:
6527:
6526:
6522:
6519:
6515:
6512:
6509:
6505:
6501:
6497:
6496:
6492:
6489:
6485:
6481:
6477:
6476:
6472:
6470:
6469:
6465:
6462:
6458:
6455:
6453:
6452:
6448:
6445:
6441:
6438:
6435:
6431:
6428:
6427:
6425:
6421:
6414:
6410:
6407:
6404:
6400:
6397:
6395:
6394:
6390:
6387:
6383:
6380:
6378:
6377:
6373:
6371:
6370:
6366:
6364:
6363:
6359:
6357:
6356:
6352:
6350:
6349:
6345:
6342:
6338:
6334:
6330:
6326:
6322:
6318:
6317:
6313:
6311:
6310:
6306:
6304:
6303:
6299:
6296:
6292:
6288:
6285:
6282:
6278:
6274:
6271:
6268:
6264:
6260:
6259:
6255:
6252:
6248:
6245:
6244:
6242:
6238:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6174:
6173:
6171:
6167:
6161:
6158:
6156:
6153:
6151:
6148:
6146:
6143:
6141:
6138:
6137:
6135:
6132:
6127:
6121:
6118:
6116:
6113:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6042:
6040:
6036:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6011:
6009:
6005:
6000:
5996:
5992:
5988:
5981:
5976:
5974:
5969:
5967:
5962:
5961:
5958:
5944:
5938:
5933:
5929:
5923:
5918:
5914:
5908:
5903:
5899:
5890:
5885:
5883:
5878:
5876:
5871:
5870:
5867:
5860:
5856:
5855:
5850:
5849:
5844:
5842:
5839:
5837:
5833:
5830:
5827:
5825:
5822:
5821:
5817:
5810:
5806:
5802:
5798:
5794:
5790:
5786:
5782:
5777:
5773:
5769:
5765:
5761:
5757:
5753:
5749:
5745:
5740:
5736:
5732:
5728:
5724:
5720:
5716:
5711:
5707:
5703:
5699:
5695:
5691:
5687:
5683:
5678:
5674:
5670:
5666:
5662:
5658:
5654:
5649:
5645:
5641:
5636:
5631:
5627:
5623:
5619:
5615:
5611:
5606:
5602:
5598:
5594:
5590:
5586:
5582:
5577:
5576:
5568:
5565:
5557:
5554:November 2020
5547:
5546:editing guide
5541:
5537:
5532:
5523:
5522:
5516:
5508:
5504:
5499:
5494:
5490:
5486:
5482:
5478:
5474:
5470:
5466:
5459:
5456:
5451:
5447:
5442:
5437:
5432:
5427:
5423:
5419:
5418:Pharmaceutics
5415:
5408:
5405:
5400:
5396:
5392:
5388:
5384:
5380:
5376:
5372:
5364:
5361:
5356:
5352:
5348:
5344:
5337:
5334:
5329:
5325:
5320:
5315:
5311:
5307:
5303:
5299:
5295:
5288:
5285:
5280:
5276:
5271:
5266:
5261:
5256:
5252:
5248:
5244:
5237:
5234:
5229:
5225:
5221:
5217:
5213:
5209:
5205:
5201:
5194:
5192:
5188:
5183:
5179:
5175:
5171:
5167:
5163:
5159:
5155:
5147:
5144:
5139:
5135:
5131:
5127:
5123:
5119:
5115:
5111:
5104:
5101:
5088:
5084:
5080:
5074:
5071:
5066:
5062:
5058:
5054:
5050:
5046:
5039:
5036:
5031:
5027:
5023:
5019:
5015:
5011:
5004:
5001:
4988:
4984:
4980:
4974:
4971:
4958:
4954:
4950:
4944:
4941:
4928:
4924:
4920:
4914:
4911:
4906:
4902:
4897:
4892:
4888:
4884:
4880:
4876:
4872:
4865:
4862:
4857:
4853:
4849:
4845:
4837:
4834:
4829:
4825:
4821:
4817:
4813:
4809:
4805:
4801:
4794:
4791:
4778:
4774:
4770:
4766:
4762:
4758:
4754:
4750:
4746:
4742:
4735:
4732:
4727:
4723:
4718:
4713:
4709:
4705:
4701:
4697:
4693:
4686:
4683:
4678:
4674:
4670:
4666:
4662:
4658:
4651:
4648:
4645:
4641:
4634:
4631:
4618:
4614:
4610:
4604:
4601:
4596:
4592:
4588:
4584:
4580:
4576:
4572:
4568:
4561:
4558:
4545:
4541:
4537:
4532:
4527:
4525:
4523:
4521:
4519:
4517:
4515:
4513:
4511:
4509:
4507:
4505:
4503:
4501:
4499:
4497:
4495:
4493:
4491:
4489:
4485:
4479:
4474:
4470:
4466:
4462:
4455:
4453:
4451:
4449:
4445:
4432:
4428:
4424:
4418:
4416:
4414:
4412:
4410:
4406:
4393:
4389:
4385:
4378:
4376:
4374:
4372:
4370:
4368:
4366:
4364:
4362:
4360:
4358:
4356:
4354:
4352:
4350:
4348:
4346:
4344:
4342:
4340:
4338:
4336:
4334:
4332:
4330:
4328:
4326:
4324:
4322:
4320:
4318:
4316:
4314:
4312:
4310:
4308:
4306:
4304:
4302:
4300:
4298:
4296:
4294:
4292:
4290:
4288:
4286:
4284:
4280:
4275:
4271:
4267:
4263:
4259:
4255:
4251:
4247:
4240:
4238:
4236:
4234:
4232:
4228:
4223:
4219:
4215:
4211:
4207:
4203:
4199:
4195:
4188:
4185:
4180:
4176:
4172:
4168:
4161:
4158:
4153:
4149:
4145:
4141:
4137:
4133:
4129:
4125:
4118:
4115:
4110:
4106:
4102:
4098:
4091:
4088:
4083:
4079:
4075:
4071:
4067:
4063:
4059:
4055:
4047:
4044:
4039:
4035:
4031:
4027:
4023:
4019:
4012:
4009:
4004:
4000:
3995:
3990:
3986:
3982:
3978:
3974:
3970:
3963:
3960:
3947:
3943:
3939:
3933:
3930:
3925:
3921:
3916:
3911:
3906:
3901:
3897:
3893:
3892:PLOS Genetics
3889:
3882:
3879:
3874:
3870:
3865:
3860:
3855:
3850:
3846:
3842:
3838:
3831:
3828:
3824:
3823:public domain
3805:
3801:
3795:
3792:
3779:
3775:
3769:
3765:
3761:
3757:
3753:
3746:
3744:
3740:
3733:
3730:
3717:
3713:
3707:
3704:
3699:
3695:
3691:
3687:
3683:
3679:
3675:
3671:
3664:
3661:
3656:
3652:
3647:
3642:
3637:
3632:
3628:
3624:
3620:
3613:
3610:
3605:
3601:
3596:
3591:
3587:
3583:
3579:
3575:
3571:
3564:
3561:
3556:
3552:
3548:
3546:9780128133811
3542:
3538:
3534:
3530:
3526:
3522:
3515:
3512:
3507:
3503:
3499:
3495:
3491:
3487:
3479:
3476:
3471:
3467:
3462:
3457:
3452:
3447:
3443:
3439:
3435:
3428:
3425:
3420:
3416:
3411:
3406:
3402:
3398:
3394:
3390:
3386:
3379:
3376:
3363:
3359:
3355:
3349:
3347:
3343:
3330:
3326:
3322:
3316:
3313:
3300:
3296:
3292:
3286:
3283:
3278:
3274:
3270:
3266:
3263:(1): 93–109.
3262:
3258:
3251:
3248:
3243:
3239:
3235:
3231:
3227:
3223:
3219:
3215:
3208:
3205:
3200:
3196:
3191:
3186:
3182:
3178:
3174:
3170:
3166:
3159:
3157:
3155:
3153:
3151:
3149:
3145:
3140:
3136:
3131:
3126:
3121:
3116:
3112:
3108:
3104:
3097:
3095:
3091:
3086:
3082:
3077:
3072:
3068:
3064:
3060:
3056:
3049:
3047:
3045:
3041:
3036:
3032:
3027:
3022:
3018:
3014:
3010:
3003:
3000:
2995:
2991:
2986:
2981:
2977:
2973:
2969:
2965:
2961:
2954:
2951:
2946:
2942:
2938:
2934:
2930:
2926:
2922:
2918:
2911:
2909:
2907:
2903:
2898:
2894:
2890:
2886:
2882:
2878:
2871:
2868:
2863:
2859:
2854:
2849:
2845:
2841:
2837:
2833:
2829:
2822:
2820:
2818:
2816:
2814:
2810:
2805:
2801:
2797:
2793:
2789:
2785:
2778:
2775:
2771:
2770:public domain
2761:
2756:
2752:
2748:
2743:
2732:
2730:
2728:
2724:
2719:
2715:
2710:
2705:
2701:
2697:
2693:
2686:
2683:
2678:
2674:
2670:
2666:
2662:
2658:
2651:
2648:
2643:
2639:
2633:
2630:
2625:
2621:
2615:
2612:
2608:
2604:
2599:
2597:
2595:
2591:
2587:
2583:
2578:
2576:
2574:
2570:
2564:
2560:
2557:
2556:
2552:
2550:
2548:
2544:
2540:
2536:
2532:
2528:
2524:
2520:
2516:
2513:
2509:
2505:
2502:
2498:
2497:vernolic acid
2494:
2490:
2489:linoleic acid
2487:
2483:
2479:
2476:
2472:
2468:
2464:
2460:
2456:
2448:
2440:
2439:St Johns Wort
2437:
2435:
2434:phenobarbital
2432:
2430:
2427:
2425:
2422:
2421:
2420:
2419:
2412:
2408:
2405:
2402:
2398:
2395:
2394:
2393:
2392:
2388:
2383:
2379:
2376:
2373:
2369:
2365:
2361:
2358:
2355:
2351:
2347:
2344:
2341:
2337:
2334:
2331:
2327:
2324:
2321:
2317:
2314:
2311:
2307:
2304:
2301:
2297:
2294:
2291:
2287:
2284:
2281:
2277:
2274:
2272:
2269:
2266:
2262:
2259:
2256:
2252:
2249:
2246:
2242:
2239:
2236:
2232:
2229:
2227:
2224:
2222:
2219:
2216:
2212:
2209:
2207:
2204:
2202:
2199:
2195:
2192:
2190:
2187:
2186:
2184:
2180:
2177:
2176:
2175:
2174:
2167:
2163:
2160:
2158:
2155:
2154:
2153:
2152:
2146:
2143:
2140:
2136:
2132:
2131:metronidazole
2129:
2126:
2122:
2119:
2116:
2112:
2109:
2108:
2107:
2106:
2100:
2097:
2094:
2090:
2086:
2085:Valproic acid
2083:
2080:
2079:antibacterial
2076:
2073:
2070:
2066:
2065:Ginkgo biloba
2062:
2061:amentoflavone
2059:
2056:
2052:
2049:
2048:
2047:
2046:
2042:
2037:
2034:
2031:
2027:
2024:
2021:
2017:
2014:
2011:
2007:
2004:
2001:
1997:
1994:
1992:
1989:
1986:
1982:
1979:
1976:
1972:
1969:
1967:
1964:
1962:
1959:
1957:
1954:
1951:
1950:loop diuretic
1947:
1944:
1941:
1937:
1934:
1931:
1927:
1926:rosiglitazone
1924:
1921:
1918:
1915:
1911:
1908:
1905:
1901:
1900:amitriptyline
1898:
1895:
1891:
1888:
1885:
1881:
1878:
1875:
1874:anticoagulant
1871:
1868:
1863:
1859:
1856:
1854:
1851:
1850:
1848:
1844:
1840:
1836:
1833:
1829:
1826:
1824:
1821:
1819:
1816:
1814:
1813:glibenclamide
1811:
1809:
1806:
1805:
1803:
1799:
1798:sulfonylureas
1796:
1793:
1789:
1786:
1783:
1780:
1777:
1776:antiepileptic
1773:
1770:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1722:
1720:
1716:
1712:
1708:
1705:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1682:
1681:
1677:
1676:
1675:
1674:
1670:
1667:
1664:
1663:
1660:
1652:
1649:
1646:
1643:
1640:
1636:
1632:
1629:
1628:
1627:
1625:
1620:
1618:
1614:
1610:
1605:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1571:
1569:
1567:
1559:
1557:
1555:
1551:
1547:
1541:
1538:
1534:
1527:
1520:
1517:
1514:
1511:
1508:
1505:
1504:
1500:
1497:
1494:
1491:
1488:
1486:
1485:
1480:
1477:
1475:
1471:
1467:
1462:
1458:
1451:
1449:
1447:
1442:
1440:
1436:
1432:
1424:
1422:
1420:
1416:
1412:
1411:vernolic acid
1408:
1404:
1403:linoleic acid
1399:
1397:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1335:
1333:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1232:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1205:acenocoumarol
1202:
1198:
1194:
1190:
1186:
1181:
1173:
1171:
1169:
1166:
1162:
1159:
1155:
1152:(abbreviated
1151:
1139:
1134:
1130:
1126:
1123:
1119:
1112:
1110:
1107:
1103:
1099:
1095:
1092:
1088:
1084:
1077:
1071:
1067:
1064:
1058:
1056:
1050:
1046:
1043:
1039:
1032:
1030:
1024:
1020:
1017:
1011:
1009:
1003:
999:
996:
994:RefSeq (mRNA)
992:
985:
981:
977:
974:
968:
967:
962:
958:
955:
953:
949:
942:
941:
936:
932:
929:
923:
922:
917:
913:
910:
908:
904:
897:
896:
891:
887:
884:
878:
877:
872:
868:
865:
863:
859:
856:
853:
851:
848:
844:
841:
837:
833:
826:
822:
817:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
747:
745:
742:
741:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
706:
704:
701:
700:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
645:
643:
640:
639:
636:
635:Gene ontology
632:
628:
616:
611:
607:
600:
593:
588:
585:
583:
579:
571:
566:
555:
551:
547:
543:
539:
535:
531:
527:
523:
519:
518:
515:
511:
506:
503:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
456:
453:
449:
444:
441:
440:
437:
435:
431:
429:
428:
424:
423:
420:
418:
414:
410:
406:
402:
394:
389:
385:
381:
376:
370:19|19 C3
366:
362:
355:
348:
342:
335:
327:
323:
319:
314:
310:
305:
301:
293:
288:
284:
280:
275:
265:
261:
254:
247:
241:
234:
230:
224:
220:
216:
211:
207:
202:
198:
194:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
136:
131:
124:
119:
114:
103:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
7502:Translocases
7499:
7486:
7473:
7460:
7447:
7437:Transferases
7434:
7421:
7278:Binding site
7214:
7207:
7200:
7182:
7175:
7157:
7151:
7145:
7141:
7137:
7133:
7129:
7111:
7104:
7086:
7079:
7072:
7065:
7058:
7049:
7042:
7037:
7030:
7023:
7016:
7001:
6994:
6987:
6980:
6973:
6966:
6959:
6952:
6933:
6914:
6907:
6888:
6881:
6874:
6856:
6849:
6842:
6835:
6828:
6806:
6788:
6746:
6730:
6716:
6704:
6697:
6690:
6652:
6634:
6622:
6608:
6594:
6587:
6571:
6550:
6540:
6530:
6523:
6513:
6493:
6473:
6466:
6456:
6449:
6439:
6429:
6408:
6398:
6391:
6381:
6374:
6367:
6360:
6353:
6346:
6314:
6307:
6300:
6286:
6272:
6256:
6246:
6069:
5942:
5927:
5912:
5853:
5847:
5784:
5780:
5747:
5743:
5718:
5714:
5681:
5656:
5652:
5617:
5613:
5584:
5580:
5560:
5551:
5539:
5475:(1): 15910.
5472:
5468:
5458:
5421:
5417:
5407:
5374:
5370:
5363:
5346:
5342:
5336:
5301:
5297:
5287:
5250:
5246:
5236:
5203:
5199:
5157:
5153:
5146:
5113:
5109:
5103:
5091:. Retrieved
5082:
5073:
5048:
5044:
5038:
5013:
5009:
5003:
4991:. Retrieved
4982:
4973:
4961:. Retrieved
4952:
4943:
4931:. Retrieved
4922:
4913:
4878:
4874:
4864:
4847:
4843:
4836:
4803:
4799:
4793:
4781:. Retrieved
4751:(1): 86–95.
4748:
4744:
4734:
4699:
4695:
4685:
4660:
4656:
4650:
4633:
4621:. Retrieved
4612:
4603:
4570:
4566:
4560:
4548:. Retrieved
4539:
4468:
4464:
4435:. Retrieved
4426:
4396:. Retrieved
4249:
4245:
4197:
4193:
4187:
4170:
4166:
4160:
4130:(1): 63–76.
4127:
4123:
4117:
4100:
4096:
4090:
4057:
4053:
4046:
4021:
4017:
4011:
3976:
3972:
3962:
3950:. Retrieved
3941:
3932:
3895:
3891:
3881:
3844:
3840:
3830:
3808:. Retrieved
3794:
3782:. Retrieved
3755:
3737:6(4):341–349
3732:
3720:. Retrieved
3706:
3676:(1): 72–78.
3673:
3669:
3663:
3626:
3622:
3612:
3577:
3573:
3563:
3537:10138/300396
3520:
3514:
3489:
3485:
3478:
3441:
3437:
3427:
3392:
3388:
3378:
3366:. Retrieved
3357:
3333:. Retrieved
3324:
3315:
3303:. Retrieved
3294:
3285:
3260:
3256:
3250:
3220:(1): 29–40.
3217:
3213:
3207:
3172:
3168:
3110:
3106:
3058:
3016:
3012:
3002:
2967:
2963:
2953:
2920:
2916:
2880:
2876:
2870:
2835:
2831:
2787:
2783:
2777:
2758:
2750:
2699:
2695:
2685:
2660:
2657:Biochemistry
2656:
2650:
2641:
2632:
2623:
2614:
2527:inflammation
2519:hypertension
2511:
2500:
2485:
2474:
2452:
2417:
2416:
2407:secobarbital
2401:bactericidal
2390:
2389:
2326:voriconazole
2255:tuberculosis
2194:promethazine
2172:
2171:
2150:
2149:
2104:
2103:
2044:
2043:
1930:antidiabetic
1839:hypertension
1802:antidiabetic
1658:
1650:
1644:
1630:
1621:
1606:
1575:
1563:
1550:flurbiprofen
1542:
1539:
1535:
1531:
1463:
1459:
1455:
1443:
1430:
1428:
1400:
1392:angiogenesis
1387:
1383:
1379:
1336:
1324:neurohormone
1320:inflammation
1312:hypertension
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1244:stereoisomer
1233:
1177:
1164:
1153:
1149:
1148:
1073:
1052:
1026:
1005:
983:
964:
938:
919:
893:
874:
854:
849:
673:heme binding
432:
425:
138:External IDs
85:
29:
7273:Active site
5987:Cytochromes
5895:PDB gallery
5653:Xenobiotica
4471:: 102–110.
3810:20 November
3325:cpicpgx.org
2970:: 108–123.
2790:: 477–494.
2535:Epoxygenase
2506:to various
2480:to various
2411:barbiturate
2378:resveratrol
2350:cannabidiol
2336:zafirlukast
2241:fluvoxamine
2231:fluvastatin
2211:fenofibrate
2121:fluconazole
2026:candesartan
1996:montelukast
1975:monoterpene
1920:nateglinide
1890:terbinafine
1823:tolbutamide
1818:glimepiride
1788:fluvastatin
1715:antipyretic
1626:, such as:
1332:epoxygenase
1225:epoxygenase
1219:, and some
1209:tolbutamide
478:gallbladder
391:39,082,388
378:39,049,459
290:94,990,091
277:94,938,658
116:Identifiers
7545:Categories
7476:Isomerases
7450:Hydrolases
7317:Regulation
7194:CYP701-999
7169:CYP501-699
7098:CYP301-499
6868:CYP101-281
5991:oxygenases
5538:" section
5424:(4): 277.
5253:(3): 713.
4993:6 February
4963:6 February
4933:13 January
4783:7 December
3938:"PharmGKB"
3784:24 January
3354:"PharmVar"
3291:"PharmGKB"
2609:, May 2017
2588:, May 2017
2565:References
2424:aprepitant
2397:rifampicin
2382:stilbenoid
2354:cannabinol
2330:antifungal
2316:teniposide
2310:antibiotic
2296:sertraline
2290:uricosuric
2286:probenecid
2261:lovastatin
2135:antibiotic
2125:antifungal
2111:amiodarone
2055:antifungal
2051:miconazole
2036:azilsartan
1981:tapentadol
1946:torasemide
1910:fluoxetine
1894:antifungal
1880:sildenafil
1870:S-warfarin
1853:irbesartan
1750:ketoprofen
1735:diclofenac
1730:lornoxicam
1685:naringenin
1680:flavonoids
1668:Inhibitors
1665:Substrates
1635:AUC values
1617:inhibitors
1609:substrates
1586:nifedipine
1546:diclofenac
1501:Caucasian
1474:amino acid
436:(ortholog)
193:1.14.14.51
159:HomoloGene
7355:EC number
7202:CYP704B22
5809:260370436
5247:Molecules
3952:30 August
3629:: 93–99.
3335:3 October
3305:3 October
2271:modafinil
2251:isoniazid
2226:flavonols
2201:bergaptol
2189:cyclizine
2162:quercetin
2157:ceritinib
2016:verapamil
2006:diltiazem
1985:analgesic
1936:tamoxifen
1828:glyburide
1808:glipizide
1772:phenytoin
1760:meloxicam
1755:piroxicam
1740:ibuprofen
1725:celecoxib
1711:analgesic
1695:quercetin
1671:Inducers
1639:clearance
1521:3.3–16.2
1506:CYP2C9*3
1217:glipizide
1201:phenytoin
1055:NP_000762
1029:NM_028191
1008:NM_000771
840:Orthologs
734:cytoplasm
540:esophagus
187:EC number
167:GeneCards
7379:Kinetics
7303:Cofactor
7266:Activity
7216:CYP720A1
7184:CYP504B1
7159:CYP318A1
7152:CYP315A1
7147:CYP314A1
7142:CYP307A2
7138:CYP307A1
7134:CYP306A1
7130:CYP302A1
7106:CYP303A1
7081:CYP199A2
7060:CYP176A1
7018:CYP154C3
6982:CYP125A1
6968:CYP119A1
6961:CYP113A1
6909:CYP106A2
6883:CYP102A1
6876:CYP101A1
6646:CYP71-99
6565:CYP51-69
6423:CYP21-49
5832:Archived
5801:15199455
5772:20497247
5764:14739630
5735:12406644
5706:11397381
5507:32985569
5450:30558213
5399:25863186
5391:22166891
5355:10820139
5328:14576103
5279:38338457
5270:10856120
5220:11936702
5182:45449460
5174:20698928
5138:26910995
5130:25470432
5087:Archived
5065:16084098
5030:19883715
4987:Archived
4983:DailyMed
4957:Archived
4953:DailyMed
4927:Archived
4923:UpToDate
4905:23785064
4856:11560871
4820:11950794
4777:Archived
4773:29133059
4765:24160757
4726:29522717
4677:16112652
4623:30 March
4617:Archived
4595:24199800
4587:15764711
4544:Archived
4437:13 March
4431:Archived
4392:Archived
4266:19074529
4222:22333299
4214:16645869
4179:11454729
4152:22669449
4144:15049511
4074:22294058
4038:25303293
4003:25499099
3946:Archived
3942:PharmGKB
3924:19300499
3873:28638342
3804:Archived
3778:Archived
3716:Archived
3698:22090671
3690:15061384
3655:28435307
3604:25099164
3555:29801580
3470:32602114
3419:31260137
3362:Archived
3329:Archived
3299:Archived
3295:PharmGKB
3277:18690857
3242:25261882
3234:16646575
3199:31075510
3139:24634501
3085:25240260
3035:26621325
2994:24345640
2945:39465144
2937:25244930
2897:21945326
2862:25093613
2804:15822186
2747:"CYP2C9"
2605:–
2584:–
2553:See also
2429:bosentan
2221:flavones
2166:flavonol
2105:Moderate
2099:Apigenin
1971:limonene
1858:losartan
1765:suprofen
1745:naproxen
1690:naringin
1678:dietary
1645:Moderate
1613:inducers
1566:PharmVar
1554:PharmVar
1518:1.1–3.6
1358:) viz.,
1213:losartan
1197:warfarin
1189:duodenum
1174:Function
1156:) is an
1122:Wikidata
819:Sources:
719:membrane
548:pancreas
520:duodenum
474:duodenum
269:10q23.33
18:CYP2C9*3
7535:Biology
7489:Ligases
7259:Enzymes
7088:CYP255A
7067:CYP183A
7032:CYP161C
7025:CYP158A
6858:CYP99A3
6851:CYP97C1
6844:CYP93E1
6837:CYP90C1
6830:CYP88D6
6699:CYP73A1
6692:CYP72A1
6240:CYP5-20
5686:Bibcode
5673:9890157
5644:9663807
5635:1873650
5601:7704034
5498:7522226
5477:Bibcode
5441:6321138
5093:21 June
4896:3834134
4828:2120209
4717:6425723
4613:PubChem
4550:5 March
4398:10 July
4109:9929518
4082:8779233
3994:4433569
3915:2652833
3864:5461284
3847:: 347.
3722:5 March
3646:5386602
3595:4206662
3506:8873220
3461:7769975
3410:6810756
3368:14 July
3190:7057225
3130:4031946
3076:4254344
2985:3914417
2853:4314516
2718:7841444
2677:2009263
2607:Ensembl
2586:Ensembl
2463:CYP2C19
2459:epoxide
2360:sesamin
2215:fibrate
2018:(minor/
2008:(minor/
1966:AM-2201
1961:JWH-018
1624:potency
1572:Ligands
1356:CYP4F3B
1352:CYP4F3A
1344:CYP4A11
1246:sets: 5
1242:(EETs)
1161:protein
952:UniProt
907:Ensembl
846:Species
825:QuickGO
536:stomach
524:jejunum
411:pattern
155:1919553
123:Aliases
7521:Portal
7463:Lyases
7209:CYP710
7177:CYP503
7113:CYP305
7074:CYP197
7038:CYP170
7003:CYP152
6996:CYP147
6989:CYP139
6975:CYP123
6954:CYP111
6935:CYP109
6916:CYP107
6890:CYP105
6129:CYP3 (
5854:CYP2C9
5848:CYP2C9
5845:Human
5807:
5799:
5770:
5762:
5733:
5704:
5671:
5642:
5632:
5599:
5534:This "
5505:
5495:
5448:
5438:
5397:
5389:
5353:
5326:
5319:253795
5316:
5277:
5267:
5228:601644
5226:
5218:
5180:
5172:
5136:
5128:
5063:
5028:
4903:
4893:
4854:
4826:
4818:
4771:
4763:
4724:
4714:
4675:
4593:
4585:
4274:285706
4272:
4264:
4220:
4212:
4177:
4150:
4142:
4107:
4080:
4072:
4036:
4001:
3991:
3922:
3912:
3871:
3861:
3770:
3696:
3688:
3653:
3643:
3602:
3592:
3553:
3543:
3504:
3468:
3458:
3417:
3407:
3275:
3240:
3232:
3197:
3187:
3137:
3127:
3083:
3073:
3033:
2992:
2982:
2943:
2935:
2895:
2860:
2850:
2802:
2716:
2675:
2471:CYP2S1
2467:CYP2J2
2455:alkene
2391:Strong
2372:sesame
2368:fagara
2364:lignan
2352:, and
2265:statin
2235:statin
2045:Strong
1792:statin
1707:NSAIDs
1631:Strong
1512:0–2.3
1498:Asian
1495:Pygmy
1431:CYP2C9
1370:, and
1354:, and
1348:CYP4F2
1340:CYP4A1
1191:, and
1165:CYP2C9
1158:enzyme
1154:CYP2C9
1108:search
1106:PubMed
966:P11712
862:Entrez
582:BioGPS
544:embryo
171:CYP2C9
163:133566
147:601130
130:CYP2C9
35:CYP2C9
7415:Types
6807:CYP81
6789:CYP80
6747:CYP79
6732:CYP76
6717:CYP75
6706:CYP74
6653:CYP71
6636:CYP61
6623:CYP56
6610:CYP55
6596:CYP53
6589:CYP52
6573:CYP51
6551:CYP46
6541:CYP39
6531:CYP35
6525:CYP29
6514:CYP28
6495:CYP27
6475:CYP26
6468:CYP25
6457:CYP24
6451:CYP23
6440:CYP22
6430:CYP21
6409:CYP20
6399:CYP19
6393:CYP18
6382:CYP17
6376:CYP16
6369:CYP15
6362:CYP14
6355:CYP13
6348:CYP12
6316:CYP11
6309:CYP10
6131:CYP3A
6001:1.14)
5805:S2CID
5768:S2CID
5395:S2CID
5224:S2CID
5178:S2CID
5134:S2CID
4824:S2CID
4769:S2CID
4591:S2CID
4270:S2CID
4218:S2CID
4148:S2CID
4078:S2CID
3694:S2CID
3238:S2CID
2941:S2CID
2744:from
2366:from
2280:NSAID
1700:rutin
1185:liver
895:72303
855:Mouse
850:Human
821:Amigo
532:colon
528:ileum
434:Mouse
427:Human
374:Start
309:Mouse
273:Start
206:Human
7507:list
7500:EC7
7494:list
7487:EC6
7481:list
7474:EC5
7468:list
7461:EC4
7455:list
7448:EC3
7442:list
7435:EC2
7429:list
7422:EC1
6302:CYP9
6287:CYP8
6273:CYP7
6258:CYP6
6247:CYP5
6169:CYP4
6038:CYP2
6007:CYP1
5943:1r9o
5928:1og5
5913:1og2
5797:PMID
5760:PMID
5731:PMID
5702:PMID
5669:PMID
5640:PMID
5597:PMID
5503:PMID
5446:PMID
5387:PMID
5351:PMID
5324:PMID
5275:PMID
5216:PMID
5170:PMID
5126:PMID
5095:2020
5061:PMID
5026:PMID
4995:2019
4965:2019
4935:2019
4901:PMID
4852:PMID
4816:PMID
4785:2017
4761:PMID
4722:PMID
4673:PMID
4625:2016
4583:PMID
4552:2010
4439:2016
4400:2011
4262:PMID
4210:PMID
4175:PMID
4140:PMID
4105:PMID
4070:PMID
4034:PMID
3999:PMID
3954:2020
3920:PMID
3869:PMID
3812:2020
3786:2022
3768:ISBN
3724:2010
3686:PMID
3651:PMID
3600:PMID
3551:PMID
3541:ISBN
3502:PMID
3466:PMID
3415:PMID
3370:2020
3337:2022
3307:2022
3273:PMID
3230:PMID
3195:PMID
3135:PMID
3081:PMID
3031:PMID
2990:PMID
2933:PMID
2893:PMID
2858:PMID
2836:1851
2800:PMID
2714:PMID
2673:PMID
2533:and
2418:Weak
2370:and
2300:SSRI
2253:(in
2245:SSRI
2151:Weak
2137:and
2067:and
1940:SERM
1914:SSRI
1882:(in
1837:(in
1651:Weak
1615:and
1596:and
1548:and
1509:2.0
1468:359-
1429:The
1417:and
1330:and
1199:and
1168:gene
876:1559
417:Bgee
365:Band
326:Chr.
264:Band
223:Chr.
143:OMIM
100:4NZ2
96:1R9O
92:1OG5
88:1OG2
69:RCSB
66:PDBe
6685:BA1
6681:AV1
6677:AJ4
6216:F22
6211:F12
6206:F11
6181:A22
6176:A11
6160:A43
6155:A37
6080:C19
6075:C18
6055:A13
5789:doi
5752:doi
5723:doi
5694:doi
5661:doi
5630:PMC
5622:doi
5589:doi
5493:PMC
5485:doi
5436:PMC
5426:doi
5379:doi
5314:PMC
5306:doi
5265:PMC
5255:doi
5208:doi
5162:doi
5158:268
5118:doi
5083:FDA
5053:doi
5018:doi
4891:PMC
4883:doi
4808:doi
4753:doi
4712:PMC
4704:doi
4700:498
4665:doi
4640:doi
4575:doi
4473:doi
4254:doi
4202:doi
4132:doi
4062:doi
4026:doi
3989:PMC
3981:doi
3977:165
3910:PMC
3900:doi
3859:PMC
3849:doi
3760:doi
3678:doi
3641:PMC
3631:doi
3590:PMC
3582:doi
3533:hdl
3525:doi
3494:doi
3456:PMC
3446:doi
3442:109
3405:PMC
3397:doi
3265:doi
3222:doi
3185:PMC
3177:doi
3125:PMC
3115:doi
3071:PMC
3063:doi
3021:doi
2980:PMC
2972:doi
2925:doi
2885:doi
2848:PMC
2840:doi
2792:doi
2704:doi
2665:doi
2362:(a
1956:THC
1847:CHF
1470:Leu
1466:Ile
1334:).
1306:to
1298:to
1290:,15
1282:,15
1274:,12
1266:,12
1075:n/a
984:n/a
387:End
286:End
175:OMA
151:MGI
59:PDB
7547::
7150:,
7144:,
7140:,
7136:,
7132:,
7128:(
7119:M2
7051:B1
7044:A1
7011:B1
7008:A1
6946:E1
6941:B1
6927:G1
6922:A1
6901:D7
6896:A1
6823:E9
6821:,
6819:E7
6817:,
6815:E3
6813:,
6811:E1
6801:G2
6799:,
6797:B1
6795:,
6793:A1
6783:D4
6781:,
6779:D3
6777:,
6775:D2
6773:,
6771:D1
6769:,
6767:B3
6765:,
6763:B2
6761:,
6759:B1
6757:,
6755:A2
6753:,
6751:A1
6741:M7
6739:,
6737:B6
6725:B1
6723:,
6721:A1
6711:D1
6683:,
6679:,
6675:,
6673:Z6
6671:,
6669:C4
6667:,
6665:C3
6663:,
6661:C2
6659:,
6657:C1
6628:A1
6616:A1
6602:A1
6582:F1
6580:,
6578:A1
6555:A1
6545:A1
6535:B1
6518:A1
6508:C1
6506:,
6504:B1
6502:,
6500:A1
6488:C1
6486:,
6484:B1
6482:,
6480:A1
6461:A1
6444:A1
6434:A2
6413:A1
6403:A1
6386:A1
6341:C1
6339:,
6337:B3
6335:,
6333:B2
6331:,
6329:B1
6327:,
6325:A2
6323:,
6321:A1
6295:B1
6293:,
6291:A1
6281:B1
6279:,
6277:A1
6267:M2
6265:,
6263:G1
6251:A1
6231:Z1
6226:X1
6221:V2
6201:F8
6196:F3
6191:F2
6186:B1
6150:A7
6145:A5
6140:A4
6120:W1
6115:U1
6110:S1
6105:R1
6100:J2
6095:F1
6090:E1
6085:D6
6070:C9
6065:C8
6060:B6
6050:A7
6045:A6
6029:B1
6024:A5
6019:A2
6014:A1
5999:EC
5993::
5989:,
5803:.
5795:.
5785:03
5783:.
5766:.
5758:.
5748:15
5746:.
5729:.
5719:54
5717:.
5700:.
5692:.
5667:.
5657:28
5655:.
5638:.
5628:.
5618:45
5616:.
5612:.
5595:.
5583:.
5501:.
5491:.
5483:.
5473:10
5471:.
5467:.
5444:.
5434:.
5422:10
5420:.
5416:.
5393:.
5385:.
5375:27
5373:.
5347:28
5345:.
5322:.
5312:.
5302:47
5300:.
5296:.
5273:.
5263:.
5251:29
5249:.
5245:.
5222:.
5214:.
5204:57
5202:.
5190:^
5176:.
5168:.
5156:.
5132:.
5124:.
5114:45
5112:.
5081:.
5059:.
5049:13
5047:.
5024:.
5014:48
5012:.
4981:.
4951:.
4925:.
4921:.
4899:.
4889:.
4879:41
4877:.
4873:.
4848:29
4846:.
4822:.
4814:.
4804:30
4802:.
4775:.
4767:.
4759:.
4749:46
4747:.
4743:.
4720:.
4710:.
4698:.
4694:.
4671:.
4661:70
4659:.
4615:.
4611:.
4589:.
4581:.
4571:33
4569:.
4538:.
4533::
4487:^
4469:50
4467:.
4463:.
4447:^
4429:.
4425:.
4408:^
4390:.
4386:.
4282:^
4268:.
4260:.
4250:37
4248:.
4230:^
4216:.
4208:.
4198:62
4196:.
4171:29
4169:.
4146:.
4138:.
4128:24
4126:.
4101:27
4099:.
4076:.
4068:.
4058:68
4056:.
4032:.
4022:15
4020:.
3997:.
3987:.
3975:.
3971:.
3944:.
3940:.
3918:.
3908:.
3894:.
3890:.
3867:.
3857:.
3843:.
3839:.
3776:.
3766:.
3742:^
3714:.
3692:.
3684:.
3674:42
3672:.
3649:.
3639:.
3627:10
3625:.
3621:.
3598:.
3588:.
3578:96
3576:.
3572:.
3549:.
3539:.
3531:.
3500:.
3488:.
3464:.
3454:.
3440:.
3436:.
3413:.
3403:.
3393:40
3391:.
3387:.
3360:.
3356:.
3345:^
3327:.
3323:.
3297:.
3293:.
3271:.
3259:.
3236:.
3228:.
3218:10
3216:.
3193:.
3183:.
3173:21
3171:.
3167:.
3147:^
3133:.
3123:.
3111:55
3109:.
3105:.
3093:^
3079:.
3069:.
3057:.
3043:^
3029:.
3015:.
3011:.
2988:.
2978:.
2968:53
2966:.
2962:.
2939:.
2931:.
2921:66
2919:.
2905:^
2891:.
2881:96
2879:.
2856:.
2846:.
2834:.
2830:.
2812:^
2798:.
2788:45
2786:.
2753:.
2749:.
2726:^
2712:.
2700:39
2698:.
2694:.
2671:.
2661:30
2659:.
2640:.
2622:.
2593:^
2572:^
2521:,
2512:4)
2501:3)
2486:2)
2475:1)
2465:,
2348:,
2185:)
2091:,
2012:)
1849:)
1845:,
1841:,
1804:)
1721:)
1717:,
1713:,
1611:,
1592:,
1588:,
1580:.
1515:0
1388:3)
1384:2)
1380:1)
1366:,
1350:,
1346:,
1342:,
1258:,6
1250:,6
1215:,
1211:,
1207:,
1187:,
823:/
393:bp
380:bp
292:bp
279:bp
173:;
169::
165:;
161::
157:;
153::
149:;
145::
98:,
94:,
90:,
7523::
7509:)
7505:(
7496:)
7492:(
7483:)
7479:(
7470:)
7466:(
7457:)
7453:(
7444:)
7440:(
7431:)
7427:(
7251:e
7244:t
7237:v
7154:)
6825:)
6809:(
6803:)
6791:(
6785:)
6749:(
6743:)
6735:(
6727:)
6719:(
6713:)
6709:(
6687:)
6655:(
6584:)
6576:(
6557:)
6553:(
6547:)
6543:(
6537:)
6533:(
6520:)
6516:(
6510:)
6498:(
6490:)
6478:(
6463:)
6459:(
6446:)
6442:(
6436:)
6432:(
6415:)
6411:(
6405:)
6401:(
6388:)
6384:(
6343:)
6319:(
6297:)
6289:(
6283:)
6275:(
6269:)
6261:(
6253:)
6249:(
6133:)
5979:e
5972:t
5965:v
5888:e
5881:t
5874:v
5861:.
5811:.
5791::
5774:.
5754::
5737:.
5725::
5708:.
5696::
5688::
5675:.
5663::
5646:.
5624::
5603:.
5591::
5585:4
5567:)
5561:(
5556:)
5552:(
5542:.
5509:.
5487::
5479::
5452:.
5428::
5401:.
5381::
5357:.
5330:.
5308::
5281:.
5257::
5230:.
5210::
5184:.
5164::
5140:.
5120::
5097:.
5067:.
5055::
5032:.
5020::
4997:.
4967:.
4937:.
4907:.
4885::
4858:.
4830:.
4810::
4787:.
4755::
4728:.
4706::
4679:.
4667::
4642::
4627:.
4597:.
4577::
4554:.
4481:.
4475::
4441:.
4402:.
4276:.
4256::
4224:.
4204::
4181:.
4154:.
4134::
4111:.
4084:.
4064::
4040:.
4028::
4005:.
3983::
3956:.
3926:.
3902::
3896:5
3875:.
3851::
3845:8
3825:.
3814:.
3788:.
3762::
3726:.
3700:.
3680::
3657:.
3633::
3606:.
3584::
3557:.
3535::
3527::
3508:.
3496::
3490:6
3472:.
3448::
3421:.
3399::
3372:.
3339:.
3309:.
3279:.
3267::
3261:2
3244:.
3224::
3201:.
3179::
3141:.
3117::
3087:.
3065::
3037:.
3023::
3017:8
2996:.
2974::
2947:.
2927::
2899:.
2887::
2864:.
2842::
2806:.
2794::
2772:.
2720:.
2706::
2679:.
2667::
2644:.
2626:.
2413:)
2409:(
2403:)
2399:(
2384:)
2374:)
2342:)
2338:(
2332:)
2328:(
2322:)
2318:(
2312:)
2308:(
2302:)
2298:(
2292:)
2288:(
2282:)
2278:(
2267:)
2263:(
2257:)
2247:)
2243:(
2237:)
2233:(
2217:)
2213:(
2181:(
2168:)
2141:)
2133:(
2127:)
2123:(
2117:)
2113:(
2095:)
2087:(
2081:)
2077:(
2071:)
2057:)
2053:(
2032:)
2028:(
2022:)
2002:)
1998:(
1987:)
1983:(
1977:)
1973:(
1952:)
1948:(
1942:)
1938:(
1932:)
1928:(
1912:(
1906:)
1902:(
1896:)
1892:(
1886:)
1876:)
1872:(
1864:)
1860:(
1800:(
1794:)
1790:(
1778:)
1774:(
1709:(
1641:.
1292:R
1288:S
1284:S
1280:R
1276:R
1272:S
1268:S
1264:R
1260:R
1256:S
1252:S
1248:R
311:)
208:)
177::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
