702:
534:
42:
240:. These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals. Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).
1617:
281:
TMEM16A is over-expressed in several tumor types. The role of TMEM16A in gliomas and the potential underlying mechanisms were analyzed by Liu et al. 2014. Knockdown of TMEM16A suppressed cell proliferation, migration and invasion.
574:
Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y, Witzgall R, Ousingsawat J, Schreiber R (January 2011). "Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells".
405:. ANO1 was the first anoctamin discovered, with three research groups independently identifying it in 2008. A single protein homologue to the vertebrate anoctamins has been found in fungi and yeast,
221:. They include proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels
1375:
Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U (October 2008). "TMEM16A confers receptor-activated calcium-dependent chloride conductance".
4701:
4652:
3417:
3262:
621:
Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R (October 2009). "Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions".
1287:
Kunzelmann K, Cabrita I, Wanitchakool P, Ousingsawat J, Sirianant L, Benedetto R, Schreiber R (March 2016). "Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC".
1621:
4469:
256:, respectively) may play a role in hearing and are required for normal function of cochlear hair cells, possibly as Ca channels or Ca channel subunits (see also family
1649:
161:
105:
557:
1018:"Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans"
272:. One of the latter two is expressed in mechanoreceptors. Tmc1 is a sodium-sensitive cation channel required for salt (Na) chemosensation in
4638:
3128:
3568:
3546:
1642:
1128:"Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-κB signaling pathway"
4746:
4736:
3441:
967:
Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della
Santina CC, Holt JR, Griffith AJ (December 2011).
920:"Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins"
4370:
1675:
724:
Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R (December 2014). "X-ray structure of a calcium-activated TMEM16 lipid scramblase".
2296:
1518:"Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles"
1324:
Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008).
826:
Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008).
2640:
1066:
4731:
3331:
3151:
1635:
883:
Pang C, Yuan H, Ren S, Chen Y, An H, Zhan Y (1 January 2014). "TMEM16A/B associated CaCC: structural and functional insights".
233:. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as
1516:
Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock JR, Harfe BD, Sanders KM, Ward SM (October 2009).
777:"Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine"
260:). Mice lacking both channels lack hair cell mechanosensory potentials. There are 8 members of this family in humans, 1 in
181:
3898:
3628:
4697:
4741:
4677:
226:
401:. Although all anoctamins are calcium-activated, not all members of this family are ion channels like ANO1; some are
4726:
278:"where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl".
4721:
4663:
4237:
3560:
3458:
3142:
2654:
369:
4565:
4483:
4384:
4301:
4170:
3593:
3490:
3322:
3091:
413:
202:
169:
1420:
Ferrera L, Caputo A, Ubby I, Bussani E, Zegarra-Moran O, Ravazzolo R, Pagani F, Galietta LJ (November 2009).
4511:
4447:
3783:
1689:
1195:
448:
402:
47:
701:
4315:
4251:
3642:
2608:
2599:
2163:
2150:
2132:
2074:
1698:
533:
274:
268:
4534:
4529:
4519:
4279:
4180:
407:
3758:
2213:
165:
2084:
3873:
2404:
2339:
2319:
1478:
1384:
1337:
1247:
1082:
839:
733:
552:
463:
2142:
2137:
2094:
1804:
1744:
4524:
2662:
2208:
2066:
1016:
Smith CJ, Watson JD, Spencer WC, O'Brien T, Cha B, Albeg A, Treinin M, Miller DM (September 2010).
117:
4603:
3224:
1969:
1914:
1909:
1874:
4085:
3848:
3778:
2934:
2929:
2832:
2707:
2564:
2539:
2439:
2309:
2183:
2031:
1994:
1894:
1889:
1789:
1774:
1769:
1734:
1559:
Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K (March 2010).
1408:
1363:
1312:
865:
757:
600:
487:
218:
3404:
2827:
2802:
2717:
2364:
2354:
1944:
1934:
1904:
1899:
1864:
1819:
1764:
1754:
1749:
4287:
3409:
3389:
3374:
3344:
2762:
2672:
2104:
2009:
1999:
1979:
1959:
1939:
4583:
4323:
4194:
4080:
4075:
4060:
3868:
3512:
3384:
3364:
2631:
2524:
2278:
2061:
1658:
1592:
1547:
1504:
1453:
1400:
1355:
1304:
1275:
1149:
1108:
1047:
998:
949:
900:
857:
808:
749:
690:
638:
592:
522:
479:
437:
156:
2812:
2792:
2188:
2168:
969:"Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes"
518:
4361:
4105:
3858:
3773:
3573:
3427:
3292:
3081:
3076:
2419:
2173:
1582:
1572:
1537:
1529:
1494:
1486:
1443:
1433:
1392:
1345:
1296:
1265:
1255:
1139:
1098:
1090:
1037:
1029:
988:
980:
939:
931:
892:
847:
798:
788:
741:
680:
672:
630:
584:
514:
471:
449:"Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM"
214:
4343:
357:
353:
148:
4613:
4608:
4578:
4407:
4402:
4005:
3970:
3960:
3925:
3532:
3507:
2974:
2667:
2549:
2193:
2119:
1704:
1666:
1223:
338:
1326:"TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity"
1071:"tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans"
828:"TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity"
1482:
1388:
1341:
1251:
1086:
843:
737:
467:
4588:
4544:
4135:
4035:
3945:
3619:
3475:
3219:
3174:
2919:
2909:
2529:
2449:
2079:
2046:
1949:
1587:
1560:
1542:
1517:
1499:
1466:
1448:
1421:
1270:
1235:
1103:
1070:
1042:
1017:
993:
968:
944:
919:
803:
776:
685:
660:
110:
505:
Hartzell C, Putzier I, Arreola J (March 2005). "Calcium-activated chloride channels".
253:
249:
4715:
4598:
4491:
4437:
4422:
4208:
4145:
3878:
3823:
3818:
3808:
3763:
3583:
3517:
3369:
3179:
3164:
3009:
2702:
2584:
2424:
2304:
2283:
2258:
2178:
1799:
1794:
1412:
1367:
1316:
869:
604:
74:
4218:
4130:
4120:
4030:
3965:
3863:
3793:
3728:
3718:
3673:
3297:
3282:
3229:
3184:
3039:
2994:
2979:
2969:
2954:
2894:
2534:
2514:
2454:
2004:
1859:
1719:
761:
676:
491:
144:
1612:
1236:"Evolution and functional divergence of the anoctamin family of membrane proteins"
1167:
257:
122:
98:
1533:
896:
86:
4269:
4223:
4100:
4095:
4090:
4015:
4000:
3995:
3950:
3929:
3921:
3833:
3828:
3813:
3798:
3733:
3678:
3254:
3244:
3239:
3234:
3214:
3199:
3189:
3169:
3071:
3054:
3044:
3034:
3024:
3019:
2989:
2964:
2959:
2939:
2924:
2889:
2874:
2837:
2772:
2732:
2722:
2579:
2574:
2559:
2544:
2484:
2349:
2253:
2248:
2243:
2233:
2228:
2109:
2056:
2051:
2036:
1879:
1854:
1844:
1834:
1824:
1814:
1729:
1724:
1714:
1033:
374:
230:
3418:
3263:
634:
41:
4573:
4501:
4496:
4432:
4427:
4417:
4412:
4392:
4213:
4202:
4198:
4165:
4050:
4045:
4020:
4010:
3985:
3980:
3975:
3916:
3906:
3888:
3883:
3853:
3843:
3803:
3768:
3723:
3713:
3708:
3703:
3688:
3653:
3578:
3522:
3499:
3467:
3394:
3354:
3312:
3302:
3277:
3249:
3209:
3194:
3114:
3109:
3049:
3029:
3014:
3004:
2869:
2859:
2787:
2782:
2777:
2767:
2727:
2682:
2677:
2589:
2569:
2509:
2499:
2429:
2409:
2394:
2384:
2374:
2359:
2344:
2334:
2324:
2314:
2273:
2268:
2263:
2238:
2218:
2198:
2124:
2114:
2099:
2089:
2041:
1989:
1924:
1849:
1839:
1829:
1809:
1784:
1779:
1759:
1739:
1709:
1490:
1300:
398:
262:
237:
210:
1260:
4593:
4539:
4455:
4338:
4328:
4259:
4188:
4150:
4125:
4115:
4040:
3990:
3935:
3911:
3838:
3748:
3743:
3738:
3698:
3693:
3683:
3668:
3527:
3399:
3379:
3359:
3349:
3307:
3287:
3204:
2999:
2914:
2904:
2884:
2822:
2807:
2797:
2757:
2742:
2712:
2697:
2692:
2687:
2613:
2554:
2504:
2494:
2489:
2474:
2464:
2444:
2434:
2414:
2389:
2019:
1984:
1964:
1929:
1919:
1884:
1869:
1577:
1438:
1350:
1325:
852:
827:
394:
285:
The reactions believed to be catalyzed by channels of the Ca-ClC family are:
4470:
1596:
1551:
1508:
1457:
1422:"Regulation of TMEM16A chloride channel properties by alternative splicing"
1404:
1359:
1308:
1279:
1153:
1112:
1051:
1002:
953:
904:
861:
812:
793:
753:
694:
642:
596:
526:
483:
1144:
1127:
935:
4264:
4070:
4065:
4025:
3940:
3788:
3663:
3601:
2984:
2949:
2854:
2469:
2399:
2369:
2329:
2223:
2014:
1974:
1954:
1627:
1234:
Milenkovic VM, Brockmann M, Stöhr H, Weber BH, Strauss O (October 2010).
547:
206:
81:
1396:
1094:
745:
588:
475:
4333:
4155:
3955:
3480:
2879:
2817:
2479:
2459:
2155:
2026:
447:
Paulino C, Kalienkova V, Lam A, Neldner Y, Dutzler R (December 2017).
441:
4159:
3272:
2944:
2864:
2747:
2737:
2519:
2288:
984:
234:
176:
17:
548:"CLCA1 chloride channel accessory 1 [Homo sapiens (human)]"
2899:
2752:
349:
345:
328:
324:
320:
316:
46:
Cartoon representation of a mTMEM16A chloride channel based on a
4397:
3100:
3062:
2845:
659:
Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM (February 2012).
334:
222:
138:
93:
69:
3423:
Tooltip G protein-coupled inwardly rectifying potassium channel
3268:
Tooltip G protein-coupled inwardly rectifying potassium channel
1631:
1168:"1.A.17 The Calcium-Dependent Chloride Channel (Ca-ClC) Family"
1467:"The TMEM16 protein family: a new class of chloride channels?"
229:, which are proteins which serve as intestinal pacemakers for
4639:
3129:
3547:
1618:
Creative
Commons Attribution-ShareAlike 3.0 Unported License
661:"Anoctamins and gastrointestinal smooth muscle excitability"
4475:
Tooltip Cystic fibrosis transmembrane conductance regulator
3442:
4371:
1676:
1616:, which is licensed in a way that permits reuse under the
308:
2641:
3332:
3152:
1613:"1.A.13 The Epithelial Chloride Channel (E-ClC) Family"
1607:
3629:
195:
Calcium-Dependent
Chloride Channel (Ca-ClC) proteins
4662:
4637:
4630:
4564:
4557:
4510:
4482:
4468:
4446:
4383:
4369:
4360:
4314:
4300:
4278:
4250:
4236:
4179:
3641:
3627:
3618:
3592:
3559:
3545:
3489:
3457:
3440:
3321:
3141:
3127:
3090:
2653:
2639:
2630:
2598:
1688:
1674:
1665:
1126:Liu J, Liu Y, Ren Y, Kang L, Zhang L (March 2014).
175:
155:
137:
132:
116:
104:
92:
80:
68:
60:
55:
34:
1561:"Expression and function of epithelial anoctamins"
299:Cations (e.g., Ca) (out) ⇌ Cations (e.g., Ca) (in)
4664:
4238:
4302:
4702:Transient receptor potential channel modulators
775:Evans SR, Thoreson WB, Beck CL (October 2004).
1190:
1188:
616:
614:
569:
567:
225:is highly expressed in human gastrointestinal
4644:Tooltip Transient receptor potential channels
3134:Tooltip Inwardly rectifying potassium channel
1643:
719:
717:
715:
713:
711:
558:National Center for Biotechnology Information
311:s that are known to occur in humans include:
8:
3552:Tooltip Tandem pore domain potassium channel
654:
652:
3450:Tooltip Calcium-activated potassium channel
4634:
4561:
4479:
4380:
4376:Tooltip Calcium-activated chloride channel
4366:
4311:
4247:
3638:
3624:
3556:
3454:
3138:
2668:4-Aminopyridine (fampridine/dalfampridine)
2650:
2636:
1685:
1681:Tooltip Voltage-dependent calcium channels
1671:
1650:
1636:
1628:
129:
40:
1586:
1576:
1541:
1498:
1447:
1437:
1349:
1269:
1259:
1143:
1102:
1041:
992:
943:
851:
802:
792:
684:
2646:Tooltip Voltage-gated potassium channels
519:10.1146/annurev.physiol.67.032003.154341
3340:Tooltip ATP-sensitive potassium channel
3160:Tooltip ATP-sensitive potassium channel
429:
386:
1624:. All relevant terms must be followed.
31:
3634:Tooltip Voltage-gated sodium channels
973:The Journal of Clinical Investigation
918:Kim KX, Fettiplace R (January 2013).
393:The anoctamins are only expressed in
201:(CaCCs), are heterogeneous groups of
7:
3569:12-O-Tetradecanoylphorbol-13-acetate
1196:"Calcium activated chloride channel"
1065:Chatzigeorgiou M, Bang S, Hwang SW,
2663:3,4-Diaminopyridine (amifampridine)
1565:The Journal of Biological Chemistry
1426:The Journal of Biological Chemistry
781:The Journal of Biological Chemistry
199:calcium-activated chloride channels
209:that have been identified in many
25:
4669:Tooltip Ligand gated ion channels
4243:Tooltip Epithelial sodium channel
1610:, this article uses content from
924:The Journal of General Physiology
4307:Tooltip Acid-sensing ion channel
1200:IUPHAR/BPS Guide to Pharmacology
700:
532:
2125:Ziconotide (ω-conotoxin MVIIA)
677:10.1113/expphysiol.2011.058248
1:
4698:Receptor/signaling modulators
2100:Leconotide (ω-conotoxin CVID)
1465:Galietta LJ (December 2009).
133:Available protein structures:
1534:10.1113/jphysiol.2009.176198
897:10.2174/09298665113206660098
1034:10.1016/j.ydbio.2010.05.502
885:Protein and Peptide Letters
507:Annual Review of Physiology
227:interstitial cells of Cajal
27:Group of transport proteins
4763:
4747:Integral membrane proteins
4737:Transmembrane transporters
3661:Antiarrhythmics (class I):
1132:Molecular Medicine Reports
635:10.1016/j.ceca.2009.09.003
4691:
4171:Tricyclic antidepressants
3180:Glibenclamide (glyburide)
1522:The Journal of Physiology
1491:10.1016/j.bpj.2009.09.024
1301:10.1007/s00424-015-1767-4
370:Voltage-gated ion channel
203:ligand-gated ion channels
128:
39:
1261:10.1186/1471-2148-10-319
1240:BMC Evolutionary Biology
414:Saccharomyces cerevisiae
403:phospholipid scramblases
3784:Eslicarbazepine acetate
1578:10.1074/jbc.M109.065367
1439:10.1074/jbc.M109.046607
1351:10.1126/science.1163518
1230:. Retrieved 2016-04-16.
853:10.1126/science.1163518
665:Experimental Physiology
48:cryoelectron microscopy
4732:Transmembrane proteins
3528:Rottlerin (mallotoxin)
1659:Ion channel modulators
794:10.1074/jbc.M408354200
301:
296:
291:
1885:Ryodipine (riodipine)
1145:10.3892/mmr.2014.1888
1022:Developmental Biology
936:10.1085/jgp.201210913
408:Aspergillus fumigatus
397:, with 10 members in
297:
292:
287:
3874:Valproate semisodium
2405:Carboxyamidotriazole
2340:Gabapentin enacarbil
2320:Arbaclofen placarbil
1620:, but not under the
1224:"TCDB » SEARCH"
577:Biological Chemistry
341:(potentially others)
217:types as well as in
4525:1,10-Phenanthroline
3082:Spooky toxin (SsTx)
2067:Tetrahydropalmatine
1528:(Pt 20): 4887–904.
1483:2009BpJ....97.3047G
1471:Biophysical Journal
1397:10.1038/nature07313
1389:2008Natur.455.1210Y
1342:2008Sci...322..590C
1252:2010BMCEE..10..319M
1095:10.1038/nature11845
1087:2013Natur.494...95C
844:2008Sci...322..590C
746:10.1038/nature13984
738:2014Natur.516..207B
589:10.1515/BC.2011.010
476:10.1038/nature24652
468:2017Natur.552..421P
219:smooth muscle cells
4742:Transport proteins
4535:7,8-Benzoquinoline
4530:4,7-Phenanthroline
4520:1,7-Phenanthroline
3896:Local anesthetics:
3428:ML-297 (VU0456810)
2935:Diallyl trisulfide
2930:Dextropropoxyphene
2833:Tetraethylammonium
2540:Pinaverium bromide
2310:4-Methylpregabalin
560:. 13 January 2015.
289:Cl (out) ⇌ Cl (in)
4727:Membrane proteins
4709:
4708:
4687:
4686:
4626:
4625:
4622:
4621:
4584:Meclofenamic acid
4553:
4552:
4464:
4463:
4356:
4355:
4352:
4351:
4296:
4295:
4232:
4231:
4106:RG7893 (GDC-0287)
3869:Valproate pivoxil
3759:Acetylpheneturide
3614:
3613:
3610:
3609:
3541:
3540:
3513:Meclofenamic acid
3476:Ethanol (alcohol)
3436:
3435:
3385:Minoxidil sulfate
3123:
3122:
2626:
2625:
2622:
2621:
2525:Otilonium bromide
2450:Ethanol (alcohol)
2214:ω-Conotoxin MVIIC
1950:Phenylalkylamines
1069:(February 2013).
787:(40): 41792–800.
462:(7685): 421–425.
191:
190:
187:
186:
182:structure summary
16:(Redirected from
4754:
4722:Protein families
4670:
4666:
4645:
4641:
4635:
4562:
4480:
4476:
4472:
4381:
4377:
4373:
4367:
4312:
4308:
4304:
4248:
4244:
4240:
3859:Sodium valproate
3774:Chlorphenacemide
3756:Anticonvulsants:
3639:
3635:
3631:
3625:
3574:Arachidonic acid
3557:
3553:
3549:
3455:
3451:
3447:
3424:
3420:
3341:
3337:
3293:Dextromethorphan
3269:
3265:
3161:
3157:
3139:
3135:
3131:
2651:
2647:
2643:
2637:
2609:L-type-selective
2420:Dimeditiapramine
2382:Others/unsorted:
2164:T-type-selective
2151:R-type-selective
2133:P-type-selective
2085:ω-Conotoxin GVIA
2075:N-type-selective
1705:Dihydropyridines
1699:L-type-selective
1686:
1682:
1678:
1672:
1652:
1645:
1638:
1629:
1600:
1590:
1580:
1555:
1545:
1512:
1502:
1461:
1451:
1441:
1416:
1383:(7217): 1210–5.
1371:
1353:
1320:
1283:
1273:
1263:
1211:
1210:
1208:
1206:
1192:
1183:
1182:
1180:
1178:
1164:
1158:
1157:
1147:
1123:
1117:
1116:
1106:
1062:
1056:
1055:
1045:
1013:
1007:
1006:
996:
985:10.1172/JCI60405
979:(12): 4796–809.
964:
958:
957:
947:
915:
909:
908:
880:
874:
873:
855:
823:
817:
816:
806:
796:
772:
766:
765:
732:(7530): 207–12.
721:
706:
705:
704:
698:
688:
656:
647:
646:
618:
609:
608:
571:
562:
561:
544:
538:
537:
536:
530:
502:
496:
495:
453:
444:
434:
418:
417:, respsectively.
391:
310:
215:endothelial cell
130:
44:
32:
21:
4762:
4761:
4757:
4756:
4755:
4753:
4752:
4751:
4712:
4711:
4710:
4705:
4683:
4668:
4658:
4643:
4618:
4614:Trifluoperazine
4609:Tolfenamic acid
4579:Flufenamic acid
4549:
4506:
4474:
4460:
4442:
4408:Flufenamic acid
4403:Ethacrynic acid
4375:
4348:
4306:
4292:
4274:
4242:
4228:
4175:
4006:Metabutoxycaine
3971:Diphenhydramine
3961:Cyclomethycaine
3926:Levobupivacaine
3633:
3606:
3588:
3551:
3537:
3533:Tolfenamic acid
3508:Flufenamic acid
3503:
3485:
3471:
3449:
3446:
3432:
3422:
3339:
3336:
3317:
3267:
3159:
3156:
3133:
3119:
3104:
3086:
3066:
2975:Norpropoxyphene
2852:11.1)-specific:
2851:
2645:
2618:
2594:
2550:Rhynchophylline
2300:
1680:
1661:
1656:
1603:
1571:(10): 7838–45.
1558:
1515:
1477:(12): 3047–53.
1464:
1432:(48): 33360–8.
1419:
1374:
1336:(5901): 590–4.
1323:
1289:Pflügers Archiv
1286:
1233:
1219:
1217:Further reading
1214:
1204:
1202:
1194:
1193:
1186:
1176:
1174:
1166:
1165:
1161:
1125:
1124:
1120:
1081:(7435): 95–99.
1064:
1063:
1059:
1015:
1014:
1010:
966:
965:
961:
917:
916:
912:
882:
881:
877:
838:(5901): 590–4.
825:
824:
820:
774:
773:
769:
723:
722:
709:
699:
658:
657:
650:
620:
619:
612:
583:(1–2): 125–34.
573:
572:
565:
546:
545:
541:
531:
504:
503:
499:
451:
446:
436:
435:
431:
427:
422:
421:
392:
388:
383:
366:
306:
250:TC#s 1.A.17.4.6
248:Tmc1 and Tmc2 (
246:
106:OPM superfamily
51:
50:reconstruction.
28:
23:
22:
15:
12:
11:
5:
4760:
4758:
4750:
4749:
4744:
4739:
4734:
4729:
4724:
4714:
4713:
4707:
4706:
4692:
4689:
4688:
4685:
4684:
4682:
4681:
4673:
4671:
4660:
4659:
4657:
4656:
4648:
4646:
4632:
4628:
4627:
4624:
4623:
4620:
4619:
4617:
4616:
4611:
4606:
4601:
4596:
4591:
4589:Mefenamic acid
4586:
4581:
4576:
4570:
4568:
4559:
4555:
4554:
4551:
4550:
4548:
4547:
4545:Phenanthridine
4542:
4537:
4532:
4527:
4522:
4516:
4514:
4508:
4507:
4505:
4504:
4499:
4494:
4488:
4486:
4477:
4466:
4465:
4462:
4461:
4459:
4458:
4452:
4450:
4444:
4443:
4441:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4389:
4387:
4378:
4364:
4358:
4357:
4354:
4353:
4350:
4349:
4347:
4346:
4341:
4336:
4331:
4326:
4320:
4318:
4309:
4298:
4297:
4294:
4293:
4291:
4290:
4284:
4282:
4276:
4275:
4273:
4272:
4267:
4262:
4256:
4254:
4245:
4234:
4233:
4230:
4229:
4227:
4226:
4221:
4216:
4211:
4206:
4193:Atracotoxins (
4191:
4185:
4183:
4177:
4176:
4174:
4173:
4168:
4163:
4153:
4148:
4139:
4138:
4136:Zetekitoxin AB
4133:
4128:
4123:
4118:
4109:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4068:
4063:
4054:
4053:
4048:
4043:
4038:
4036:Proxymetacaine
4033:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3946:Chloroprocaine
3943:
3938:
3933:
3919:
3914:
3909:
3904:
3892:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3752:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3657:
3656:
3647:
3645:
3636:
3622:
3616:
3615:
3612:
3611:
3608:
3607:
3605:
3604:
3598:
3596:
3590:
3589:
3587:
3586:
3581:
3576:
3571:
3565:
3563:
3554:
3543:
3542:
3539:
3538:
3536:
3535:
3530:
3525:
3520:
3515:
3510:
3501:
3495:
3493:
3487:
3486:
3484:
3483:
3478:
3469:
3463:
3461:
3452:
3444:
3438:
3437:
3434:
3433:
3431:
3430:
3413:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3334:
3327:
3325:
3319:
3318:
3316:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3258:
3257:
3252:
3247:
3242:
3237:
3232:
3227:
3222:
3220:Glyclopyramide
3217:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3175:Chlorpropamide
3172:
3167:
3154:
3147:
3145:
3136:
3125:
3124:
3121:
3120:
3118:
3117:
3112:
3102:
3096:
3094:
3088:
3087:
3085:
3084:
3079:
3074:
3064:
3058:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2920:Clarithromycin
2917:
2912:
2910:Chlorpromazine
2907:
2902:
2897:
2892:
2887:
2882:
2877:
2872:
2867:
2862:
2857:
2849:
2841:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2659:
2657:
2648:
2634:
2628:
2627:
2624:
2623:
2620:
2619:
2617:
2616:
2604:
2602:
2596:
2595:
2593:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2530:Paramethadione
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2447:
2442:
2437:
2432:
2427:
2422:
2417:
2412:
2407:
2402:
2397:
2392:
2387:
2378:
2377:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2305:gabapentinoids
2298:
2292:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2206:Non-selective:
2202:
2201:
2196:
2191:
2186:
2181:
2176:
2171:
2159:
2158:
2146:
2145:
2143:ω-Agatoxin IVB
2140:
2138:ω-Agatoxin IVA
2128:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2095:Huwentoxin XVI
2092:
2087:
2082:
2070:
2069:
2064:
2059:
2054:
2049:
2047:Cyproheptadine
2044:
2039:
2034:
2029:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1977:
1972:
1967:
1962:
1957:
1942:
1937:
1932:
1927:
1912:
1907:
1902:
1897:
1892:
1887:
1882:
1877:
1872:
1867:
1862:
1857:
1852:
1847:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1807:
1805:Levniguldipine
1802:
1797:
1792:
1787:
1782:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1745:Dexniguldipine
1742:
1737:
1732:
1727:
1722:
1717:
1712:
1694:
1692:
1683:
1669:
1663:
1662:
1657:
1655:
1654:
1647:
1640:
1632:
1602:
1601:
1556:
1513:
1462:
1417:
1372:
1321:
1284:
1231:
1220:
1218:
1215:
1213:
1212:
1184:
1159:
1138:(3): 1068–74.
1118:
1057:
1008:
959:
910:
875:
818:
767:
707:
648:
610:
563:
539:
497:
428:
426:
423:
420:
419:
385:
384:
382:
379:
378:
377:
372:
365:
362:
361:
360:
342:
331:
305:
302:
245:
242:
189:
188:
185:
184:
179:
173:
172:
159:
153:
152:
142:
135:
134:
126:
125:
120:
114:
113:
108:
102:
101:
96:
90:
89:
84:
78:
77:
72:
66:
65:
62:
58:
57:
53:
52:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4759:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4719:
4717:
4704:
4703:
4699:
4696:
4690:
4679:
4675:
4674:
4672:
4667:
4661:
4654:
4650:
4649:
4647:
4642:
4636:
4633:
4629:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4599:Niflumic acid
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4571:
4569:
4567:
4563:
4560:
4556:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4517:
4515:
4513:
4509:
4503:
4500:
4498:
4495:
4493:
4492:Glibenclamide
4490:
4489:
4487:
4485:
4481:
4478:
4473:
4467:
4457:
4454:
4453:
4451:
4449:
4445:
4439:
4438:Niflumic acid
4436:
4434:
4431:
4429:
4426:
4424:
4423:Glibenclamide
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4390:
4388:
4386:
4382:
4379:
4374:
4368:
4365:
4363:
4359:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4321:
4319:
4317:
4313:
4310:
4305:
4299:
4289:
4286:
4285:
4283:
4281:
4277:
4271:
4268:
4266:
4263:
4261:
4258:
4257:
4255:
4253:
4249:
4246:
4241:
4235:
4225:
4222:
4220:
4219:Grayanotoxins
4217:
4215:
4212:
4210:
4209:Batrachotoxin
4207:
4204:
4200:
4196:
4195:ω-Atracotoxin
4192:
4190:
4187:
4186:
4184:
4182:
4178:
4172:
4169:
4167:
4164:
4161:
4157:
4154:
4152:
4149:
4147:
4146:Buprenorphine
4144:
4141:
4140:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4111:
4110:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4056:
4055:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3931:
3927:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3901:
3897:
3894:
3893:
3890:
3887:
3885:
3882:
3880:
3879:Valproic acid
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3824:Oxitriptyline
3822:
3820:
3819:Oxcarbazepine
3817:
3815:
3812:
3810:
3809:Licarbazepine
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3764:Carbamazepine
3762:
3760:
3757:
3754:
3753:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3659:
3658:
3655:
3652:
3651:Antianginals:
3649:
3648:
3646:
3644:
3640:
3637:
3632:
3626:
3623:
3621:
3617:
3603:
3600:
3599:
3597:
3595:
3591:
3585:
3584:Norfluoxetine
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3566:
3564:
3562:
3558:
3555:
3550:
3544:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3518:Niflumic acid
3516:
3514:
3511:
3509:
3506:
3504:
3497:
3496:
3494:
3492:
3488:
3482:
3479:
3477:
3474:
3472:
3465:
3464:
3462:
3460:
3456:
3453:
3448:
3439:
3429:
3426:
3421:
3415:
3414:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3370:Levcromakalim
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3338:
3329:
3328:
3326:
3324:
3320:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3266:
3260:
3259:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3165:Acetohexamide
3163:
3158:
3149:
3148:
3146:
3144:
3140:
3137:
3132:
3126:
3116:
3113:
3111:
3108:
3106:
3098:
3097:
3095:
3093:
3089:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3060:
3059:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3010:Roxithromycin
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2847:
2843:
2842:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2703:Charybdotoxin
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2660:
2658:
2656:
2652:
2649:
2644:
2638:
2635:
2633:
2629:
2615:
2612:
2610:
2606:
2605:
2603:
2601:
2597:
2591:
2588:
2586:
2585:Trimethadione
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2428:
2426:
2425:Diproteverine
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2380:
2379:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2302:
2294:
2293:
2290:
2287:
2285:
2284:Ruthenium red
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2259:Levetiracetam
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2209:ω-Agatoxin TK
2207:
2204:
2203:
2200:
2197:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2179:Niflumic acid
2177:
2175:
2172:
2170:
2167:
2165:
2161:
2160:
2157:
2154:
2152:
2148:
2147:
2144:
2141:
2139:
2136:
2134:
2130:
2129:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2091:
2088:
2086:
2083:
2081:
2078:
2076:
2072:
2071:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1958:
1956:
1953:
1951:
1946:
1943:
1941:
1938:
1936:
1933:
1931:
1928:
1926:
1923:
1921:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1800:Levamlodipine
1798:
1796:
1795:Lercanidipine
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1702:
1700:
1696:
1695:
1693:
1691:
1687:
1684:
1679:
1673:
1670:
1668:
1664:
1660:
1653:
1648:
1646:
1641:
1639:
1634:
1633:
1630:
1626:
1625:
1623:
1619:
1614:
1611:
1609:
1598:
1594:
1589:
1584:
1579:
1574:
1570:
1566:
1562:
1557:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1514:
1510:
1506:
1501:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1463:
1459:
1455:
1450:
1445:
1440:
1435:
1431:
1427:
1423:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1373:
1369:
1365:
1361:
1357:
1352:
1347:
1343:
1339:
1335:
1331:
1327:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1295:(3): 475–90.
1294:
1290:
1285:
1281:
1277:
1272:
1267:
1262:
1257:
1253:
1249:
1245:
1241:
1237:
1232:
1229:
1225:
1222:
1221:
1216:
1201:
1197:
1191:
1189:
1185:
1173:
1169:
1163:
1160:
1155:
1151:
1146:
1141:
1137:
1133:
1129:
1122:
1119:
1114:
1110:
1105:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1061:
1058:
1053:
1049:
1044:
1039:
1035:
1031:
1027:
1023:
1019:
1012:
1009:
1004:
1000:
995:
990:
986:
982:
978:
974:
970:
963:
960:
955:
951:
946:
941:
937:
933:
929:
925:
921:
914:
911:
906:
902:
898:
894:
890:
886:
879:
876:
871:
867:
863:
859:
854:
849:
845:
841:
837:
833:
829:
822:
819:
814:
810:
805:
800:
795:
790:
786:
782:
778:
771:
768:
763:
759:
755:
751:
747:
743:
739:
735:
731:
727:
720:
718:
716:
714:
712:
708:
703:
696:
692:
687:
682:
678:
674:
670:
666:
662:
655:
653:
649:
644:
640:
636:
632:
629:(4): 233–41.
628:
624:
617:
615:
611:
606:
602:
598:
594:
590:
586:
582:
578:
570:
568:
564:
559:
555:
554:
549:
543:
540:
535:
528:
524:
520:
516:
512:
508:
501:
498:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
450:
443:
439:
433:
430:
424:
416:
415:
410:
409:
404:
400:
396:
390:
387:
380:
376:
373:
371:
368:
367:
363:
359:
355:
351:
347:
344:Bestrophins:
343:
340:
336:
332:
330:
326:
322:
318:
315:Accessories:
314:
313:
312:
303:
300:
295:
290:
286:
283:
279:
277:
276:
271:
270:
265:
264:
259:
255:
251:
243:
241:
239:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
183:
180:
178:
174:
171:
167:
163:
160:
158:
154:
150:
146:
143:
140:
136:
131:
127:
124:
121:
119:
115:
112:
109:
107:
103:
100:
97:
95:
91:
88:
85:
83:
79:
76:
73:
71:
67:
63:
59:
54:
49:
43:
38:
33:
30:
19:
4694:
4693:
4604:Talniflumate
4142:
4131:Tetrodotoxin
4121:Neosaxitoxin
4112:
4057:
4031:Propoxycaine
3966:Dimethocaine
3899:
3895:
3864:Valnoctamide
3794:Fosphenytoin
3755:
3729:Procainamide
3719:Pilsicainide
3674:Disopyramide
3660:
3650:
3498:
3466:
3416:
3330:
3298:Ethosuximide
3283:Cloperastine
3261:
3230:Metahexamide
3225:Glycyclamide
3185:Glibornuride
3150:
3099:
3061:
3040:Thioridazine
2995:Promethazine
2980:Orphenadrine
2970:Ketoconazole
2955:Erythromycin
2844:
2607:
2535:Phensuximide
2515:Ochratoxin A
2455:Ethosuximide
2381:
2303:-selective (
2295:
2205:
2162:
2149:
2131:
2080:ω-Conotoxins
2073:
2023:
2005:Norverapamil
1970:Dexverapamil
1948:
1922:derivatives:
1918:
1915:Vatanidipine
1910:Trombodipine
1875:Palonidipine
1860:Nitrendipine
1815:Mepirodipine
1720:Azelnidipine
1703:
1697:
1615:
1605:
1604:
1568:
1564:
1525:
1521:
1474:
1470:
1429:
1425:
1380:
1376:
1333:
1329:
1292:
1288:
1243:
1239:
1228:www.tcdb.org
1227:
1203:. Retrieved
1199:
1175:. Retrieved
1171:
1162:
1135:
1131:
1121:
1078:
1074:
1060:
1028:(1): 18–33.
1025:
1021:
1011:
976:
972:
962:
930:(1): 141–8.
927:
923:
913:
888:
884:
878:
835:
831:
821:
784:
780:
770:
729:
725:
671:(2): 200–6.
668:
664:
626:
623:Cell Calcium
622:
580:
576:
551:
542:
510:
506:
500:
459:
455:
432:
412:
406:
389:
333:Anoctamins:
307:
298:
293:
288:
284:
280:
273:
267:
261:
247:
198:
194:
192:
29:
4270:Triamterene
4224:Poneratoxin
4214:Ciguatoxins
4101:Raxatrigine
4096:Ralfinamide
4091:PF-05089771
4086:PF-04531083
4058:Analgesics:
4016:Piperocaine
4001:Meprylcaine
3996:Mepivacaine
3951:Cinchocaine
3930:Ropivacaine
3922:Bupivacaine
3849:Sipatrigine
3834:Pheneturide
3829:Phenacemide
3814:Mephenytoin
3799:Lamotrigine
3779:Elpetrigine
3734:Propafenone
3679:Dronedarone
3255:Tolbutamide
3245:Repaglinide
3240:Nateglinide
3235:Mitiglinide
3215:Glisoxepide
3200:Glimepiride
3190:Glicaramide
3170:Carbutamide
3072:Linopirdine
3055:Vernakalant
3045:Tolterodine
3035:Terfenadine
3025:Tamulotoxin
3020:Solifenacin
2990:PNU-282,987
2965:Haloperidol
2960:Gigactonine
2940:Domperidone
2925:Darifenacin
2890:Bedaquiline
2875:Azaspiracid
2838:Vernakalant
2773:Linopirdine
2733:Dronedarone
2723:Dendrotoxin
2708:Clamikalant
2580:Tolperisone
2575:Tetrandrine
2565:Sipatrigine
2560:Silperisone
2545:Prenylamine
2485:Lidoflazine
2440:Elpetrigine
2350:Mirogabalin
2254:Lamotrigine
2249:Flunarizine
2244:Efonidipine
2234:Cinnarizine
2229:Cilnidipine
2184:NNC 55-0396
2110:Ralfinamide
2057:Fantofarone
2052:Dronedarone
2037:Budiodarone
2032:Brinazarone
1995:Levemopamil
1895:Sornidipine
1890:Sagandipine
1880:Pranidipine
1855:Nisoldipine
1845:Nilvadipine
1835:Niguldipine
1825:Nicardipine
1790:Lemildipine
1775:Iganidipine
1770:Furnidipine
1735:Cronidipine
1730:Clevidipine
1725:Barnidipine
1715:Aranidipine
891:(1): 94–9.
399:vertebrates
375:Ion channel
238:suppressors
231:peristalsis
56:Identifiers
4716:Categories
4574:Bumetanide
4512:Activators
4502:Piretanide
4497:Lonidamine
4448:Activators
4433:Mibefradil
4428:Mefloquine
4418:Furosemide
4413:Fluoxetine
4393:Crofelemer
4280:Activators
4203:Versutoxin
4199:Robustoxin
4181:Activators
4166:Safinamide
4116:Conotoxins
4051:Trimecaine
4046:Tetracaine
4021:Prilocaine
4011:Orthocaine
3986:Iontocaine
3981:Hexylcaine
3976:Etidocaine
3917:Benzocaine
3907:Amylocaine
3889:Zonisamide
3884:Valpromide
3854:Topiramate
3844:Rufinamide
3804:Lacosamide
3769:Cenobamate
3724:Prajmaline
3714:Moricizine
3709:Mexiletine
3704:Lorcainide
3689:Flecainide
3654:Ranolazine
3594:Activators
3579:Fluoxetine
3523:Nimesulide
3505:-specific:
3491:Activators
3473:-specific:
3425:-specific:
3405:Rilmakalim
3395:Nicorandil
3355:Cromakalim
3342:-specific:
3323:Activators
3313:Tipepidine
3303:Ifenprodil
3278:Caramiphen
3270:-specific:
3250:Tolazamide
3210:Gliquidone
3195:Gliclazide
3162:-specific:
3115:Retigabine
3110:Flupirtine
3107:-specific:
3092:Activators
3069:-specific:
3050:Vanoxerine
3030:Terodiline
3015:Sertindole
3005:Ranolazine
2870:Astemizole
2860:Amiodarone
2828:Terikalant
2803:Pinokalant
2788:Nifekalant
2783:Maurotoxin
2778:Lolitrem B
2768:Kaliotoxin
2728:Dofetilide
2718:Dalazatide
2713:Conotoxins
2683:Amiodarone
2678:Almokalant
2600:Activators
2590:Valperinol
2570:Terodiline
2510:Naftopidil
2500:Mesuximide
2430:Enpiperate
2410:Cycleanine
2395:Bevantolol
2385:Bencyclane
2375:Pregabalin
2365:PD-299,685
2360:PD-217,014
2355:PD-200,347
2345:Imagabalin
2335:Gabapentin
2325:Atagabalin
2315:Arbaclofen
2274:Mibefradil
2269:Loperamide
2264:Lomerizine
2239:Dotarizine
2219:Benidipine
2199:Zonisamide
2115:Safinamide
2090:Caroverine
2042:Celivarone
1990:Gallopamil
1945:Siratiazem
1935:Iprotiazem
1925:Clentiazem
1905:Tiamdipine
1900:Teludipine
1865:Olradipine
1850:Nimodipine
1840:Niludipine
1830:Nifedipine
1820:Mesudipine
1810:Manidipine
1785:Lacidipine
1780:Isradipine
1765:Flordipine
1760:Felodipine
1755:Elnadipine
1750:Elgodipine
1740:Darodipine
1710:Amlodipine
1246:(1): 319.
1067:Schafer WR
513:: 719–58.
425:References
395:eukaryotes
275:C. elegans
269:C. elegans
263:Drosophila
258:TC# 1.A.82
254:1.A.17.4.1
211:epithelial
145:structures
118:Membranome
4695:See also:
4594:Mepacrine
4540:Ivacaftor
4456:Carbachol
4339:Ibuprofen
4329:Amiloride
4288:Solnatide
4260:Amiloride
4189:Aconitine
4151:Evenamide
4126:Saxitoxin
4041:Risocaine
3991:Lidocaine
3936:Butacaine
3912:Articaine
3839:Phenytoin
3749:Tocainide
3744:Sparteine
3739:Quinidine
3699:Lorajmine
3694:Lidocaine
3684:Encainide
3669:Aprindine
3410:Sarakalim
3400:Pinacidil
3390:Naminidil
3380:Minoxidil
3375:Mazokalim
3360:Diazoxide
3350:Bimakalim
3345:Aprikalim
3308:Tertiapin
3288:Clozapine
3205:Glipizide
3000:Quinidine
2950:Ergtoxins
2915:Cisapride
2905:BRL-32872
2885:Azimilide
2848:(KCNH2, K
2823:Tedisamil
2808:Quinidine
2798:Paxilline
2763:Inakalant
2758:Ibutilide
2743:Hanatoxin
2698:Bunaftine
2693:Bretylium
2688:Azimilide
2673:Adekalant
2632:Potassium
2614:Bay K8644
2555:Sesamodil
2505:Monatepil
2495:Manoalide
2490:Magnesium
2475:Imepitoin
2465:Fendiline
2445:Ethadione
2435:Eperisone
2415:Dauricine
2390:Berbamine
2301:δ subunit
2105:PD-173212
2020:Verapamil
2010:Ronipamil
2000:Nexopamil
1985:Falipamil
1980:Etripamil
1965:Devapamil
1960:Dagapamil
1940:Nictiazem
1930:Diltiazem
1920:Diltiazem
1870:Oxodipine
1608:this edit
1413:205214858
1205:7 October
445:;
304:In humans
266:and 2 in
87:IPR032394
64:Apoctamin
4680:instead.
4655:instead.
4566:Blockers
4558:Unsorted
4484:Blockers
4385:Blockers
4362:Chloride
4324:A-317567
4316:Blockers
4265:Benzamil
4252:Blockers
4081:NKTR-171
4076:GDC-0276
4071:Funapide
4066:DSP-2230
4061:AZD-3161
4026:Procaine
3941:Butamben
3789:Ethotoin
3664:Ajmaline
3643:Blockers
3602:Riluzole
3561:Blockers
3459:Blockers
3365:Emakalim
3143:Blockers
2985:Pimozide
2855:Ajmaline
2655:Blockers
2470:Fostedil
2400:Canadine
2370:Phenibut
2330:Baclofen
2279:NP078585
2224:Bepridil
2062:SR-33805
2015:Tiapamil
1975:Emopamil
1955:Anipamil
1690:Blockers
1597:20056604
1552:19687122
1509:20006941
1458:19819874
1405:18724360
1368:52870095
1360:18772398
1317:14374080
1309:26700940
1280:20964844
1177:16 April
1154:24401903
1113:23364694
1052:20537990
1003:22105175
954:23277480
905:24151904
870:52870095
862:18772398
813:15284223
754:25383531
695:22002868
643:19783045
605:24285022
597:21194364
527:15709976
484:29236691
364:See also
244:Function
207:chloride
162:RCSB PDB
82:InterPro
4334:Aspirin
4156:Menthol
4143:Others:
4113:Toxins:
3956:Cocaine
3481:GAL-021
3101:KCNQ (K
3063:KCNQ (K
2880:AZD1305
2818:Sotalol
2813:ShK-186
2793:Notoxin
2480:JTV-519
2460:Fasudil
2189:ProTx I
2169:ABT-639
2156:SNX-482
2027:AH-1058
2024:Others:
1667:Calcium
1588:2844227
1543:2770154
1500:2793353
1479:Bibcode
1449:2785179
1385:Bibcode
1338:Bibcode
1330:Science
1271:2974728
1248:Bibcode
1104:4021456
1083:Bibcode
1043:2919608
994:3223072
945:3536526
840:Bibcode
832:Science
804:1383427
762:1396768
734:Bibcode
686:3272164
492:4457894
464:Bibcode
75:PF04547
4631:Others
3620:Sodium
3273:Barium
3077:XE-991
2945:E-4031
2895:BeKm-1
2865:AmmTX3
2748:HgeTx1
2738:E-4031
2520:Osthol
2289:TROX-1
2174:ML-218
1606:As of
1595:
1585:
1550:
1540:
1507:
1497:
1456:
1446:
1411:
1403:
1377:Nature
1366:
1358:
1315:
1307:
1278:
1268:
1152:
1111:
1101:
1075:Nature
1050:
1040:
1001:
991:
952:
942:
903:
868:
860:
811:
801:
760:
752:
726:Nature
693:
683:
641:
603:
595:
525:
490:
482:
456:Nature
356:, and
327:, and
235:tumour
177:PDBsum
151:
141:
99:1.A.17
61:Symbol
35:TMEM16
4665:LGICs
4372:CaCCs
4344:PcTX1
4303:ASICs
3630:VGSCs
2900:BmTx3
2753:HsTx1
2642:VGKCs
1677:VDCCs
1409:S2CID
1364:S2CID
1313:S2CID
866:S2CID
758:S2CID
601:S2CID
488:S2CID
452:(PDF)
381:Notes
358:BEST4
354:BEST3
350:BEST2
346:BEST1
329:CLCA4
325:CLCA3
321:CLCA2
317:CLCA1
4678:here
4676:See
4653:here
4651:See
4640:TRPs
4471:CFTR
4398:DIDS
4239:ENaC
4160:mint
3548:K2Ps
3419:GIRK
3264:GIRK
3130:IRKs
2846:hERG
2194:Z944
2120:Z160
1622:GFDL
1593:PMID
1548:PMID
1505:PMID
1454:PMID
1401:PMID
1356:PMID
1305:PMID
1276:PMID
1207:2015
1179:2016
1172:TCDB
1150:PMID
1109:PMID
1048:PMID
999:PMID
950:PMID
901:PMID
858:PMID
809:PMID
750:PMID
691:PMID
639:PMID
593:PMID
553:Gene
523:PMID
480:PMID
442:5oyb
411:and
339:ANO2
337:and
335:ANO1
309:CaCC
252:and
223:ANO1
213:and
205:for
197:(or
193:The
170:PDBj
166:PDBe
149:ECOD
139:Pfam
94:TCDB
70:Pfam
18:CaCC
3902:FBT
3335:ATP
3155:ATP
1583:PMC
1573:doi
1569:285
1538:PMC
1530:doi
1526:587
1495:PMC
1487:doi
1444:PMC
1434:doi
1430:284
1393:doi
1381:455
1346:doi
1334:322
1297:doi
1293:468
1266:PMC
1256:doi
1140:doi
1099:PMC
1091:doi
1079:494
1038:PMC
1030:doi
1026:345
989:PMC
981:doi
977:121
940:PMC
932:doi
928:141
893:doi
848:doi
836:322
799:PMC
789:doi
785:279
742:doi
730:516
681:PMC
673:doi
631:doi
585:doi
581:392
515:doi
472:doi
460:552
438:PDB
294:and
157:PDB
123:219
111:369
4718::
4700:•
4201:,
4197:,
3928:,
3502:Ca
3500:BK
3470:Ca
3468:BK
3445:Ca
3105:7)
3067:7)
2307:):
2022:;
1947:;
1917:;
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