312:
289:
186:
211:
2196:
563:
2211:
318:
217:
31:
2166:
2181:
2151:
2606:
1245:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a
1689:
Ishiguro H, Higashiyama S, Namikawa C, Kunimatsu M, Takano E, Tanaka K, Ohkubo I, Murachi T, Sasaki M (1987). "Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations".
57:
1754:
Corasaniti MT, Navarra M, Catani MV, Melino G, Nisticò G, Finazzi-Agrò A (1996). "NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain".
1784:
Fujitani K, Kambayashi J, Sakon M, Ohmi SI, Kawashima S, Yukawa M, Yano Y, Miyoshi H, Ikeda M, Shinoki N, Monden M (1997). "Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells".
1947:
Masumoto H, Nakagawa K, Irie S, Sorimachi H, Suzuki K, Bourenkov GP, Bartunik H, Fernandez-Catalan C, Bode W, Strobl S (2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain".
1448:
Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W (Jul 2002).
1357:
Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K (1988). "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease".
2195:
1246:
common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.
1660:
Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (1990). "Four genes for the calpain family locate on four distinct human chromosomes".
325:
224:
1824:"Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events"
2251:
1721:"The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32"
956:
147:
937:
2210:
1894:
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W (2000).
1395:"Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease"
2675:
2651:
2130:
1719:
Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES (1996).
1339:
2680:
2670:
1567:
Reverter D, Sorimachi H, Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function".
1321:
1495:
Suzuki K, Sorimachi H, Yoshizawa T, Kinbara K, Ishiura S (1995). "Calpain: novel family members, activation, and physiologic function".
1798:
1164:
311:
2090:
2080:
1171:
2165:
1857:
Ueyama H, Kumamoto T, Fujimoto S, Murakami T, Tsuda T (1998). "Expression of three calpain isoform genes in human skeletal muscles".
2180:
288:
2244:
1434:
1308:
1287:
1896:"The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium"
1304:
2096:
210:
185:
54:
2020:
Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH (2000). "Neurotoxicity induces cleavage of p35 to p25 by calpain".
1283:
127:
2150:
2397:
2237:
1255:
324:
223:
1627:"Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I"
317:
216:
2644:
2271:
2123:
2268:
1001:
135:
2204:: Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation
2462:
982:
1596:
Kopp S (1976). "Reproducibility of response to a questionnaire on symptoms of masticatory dysfunction".
2637:
2116:
2029:
1957:
1907:
199:
114:
2555:
2102:
1122:
1071:
2053:
1882:
1810:
159:
1987:"Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases"
1147:
1126:
1096:
1075:
1625:
Adachi Y, Kitahara-Ozawa A, Sugamura K, Lee WJ, Yodoi J, Maki M, Murachi T, Hatanaka M (1992).
2264:
2045:
2008:
1973:
1935:
1874:
1845:
1802:
1772:
1742:
1707:
1677:
1648:
1613:
1584:
1555:
1512:
1472:
1416:
1375:
107:
47:
2621:
2575:
2467:
2457:
2452:
2447:
2442:
2229:
2037:
1998:
1965:
1925:
1915:
1866:
1835:
1794:
1764:
1732:
1699:
1669:
1638:
1605:
1576:
1545:
1537:
1504:
1462:
1406:
1367:
404:
335:
279:
234:
2422:
2077:
562:
155:
2084:
1451:"Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members"
379:
2033:
1961:
1911:
1609:
1550:
1525:
30:
1870:
1643:
1626:
1580:
1411:
1394:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
2664:
2057:
1930:
1895:
1886:
591:
1814:
2617:
2514:
2510:
397:
176:
139:
1508:
163:
2585:
2580:
2550:
2534:
2529:
2524:
2519:
2505:
2500:
2495:
2490:
2485:
1344:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1326:
National Center for
Biotechnology Information, U.S. National Library of Medicine
480:
2565:
2379:
2348:
2343:
2338:
2333:
1969:
296:
193:
143:
1840:
1823:
1737:
1720:
2570:
2477:
2432:
2427:
2417:
2407:
2374:
2328:
2323:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
901:
540:
418:
363:
350:
262:
249:
151:
2049:
2012:
2003:
1986:
1977:
1939:
1768:
1588:
1476:
1467:
1450:
1920:
1878:
1849:
1806:
1799:
10.1002/(SICI)1097-4644(19970801)66:2<197::AID-JCB7>3.0.CO;2-L
1776:
1746:
1711:
1681:
1652:
1617:
1559:
1516:
1420:
1379:
1211:
1206:
2560:
2260:
1195:
1046:
1027:
1703:
1371:
2389:
2280:
1227:
1013:
968:
1673:
1541:
84:
80:
76:
2437:
2369:
2364:
2073:
2041:
1179:
923:
2605:
2412:
1259:
886:
882:
2613:
1234:
131:
2233:
2112:
872:
positive regulation of phosphatidylcholine biosynthetic process
2219:: Crystal Structure analysis of rat m-calpain mutant Lys10 Thr
2108:
571:
832:
positive regulation of cardiac muscle cell apoptotic process
807:
proteolysis involved in cellular protein catabolic process
387:
2625:
645:
calcium-dependent cysteine-type endopeptidase activity
2076:
online database for peptidases and their inhibitors:
552:
1435:"Entrez Gene: CAPN2 calpain 2, (m/II) large subunit"
2543:
2476:
2388:
2357:
2279:
1140:
1115:
1089:
1064:
1300:
1298:
1296:
1279:
1277:
1275:
334:
233:
2174:: Crystal Structure of Human m-Calpain Form II
1393:Hata A, Ohno S, Akita Y, Suzuki K (May 1989).
1305:GRCm38: Ensembl release 89: ENSMUSG00000026509
2645:
2245:
2189:: Crystal Structure of Human m-Calpain Form I
2124:
8:
1284:GRCh38: Ensembl release 89: ENSG00000162909
2652:
2638:
2252:
2238:
2230:
2131:
2117:
2109:
897:
587:
375:
274:
171:
65:
2002:
1929:
1919:
1839:
1736:
1642:
1549:
1526:"Caspases: the executioners of apoptosis"
1466:
1410:
118:, CANP2, CANPL2, CANPml, mCANP, calpain 2
797:cellular response to amino acid stimulus
2146:
1822:Rock MT, Brooks WH, Roszman TL (1997).
1271:
857:cellular response to lipopolysaccharide
812:regulation of cytoskeleton organization
867:positive regulation of myoblast fusion
837:regulation of interleukin-6 production
20:
339:
300:
295:
238:
197:
192:
7:
2602:
2600:
842:cellular response to interferon-beta
491:endothelial cell of lymphatic vessel
862:positive regulation of neuron death
635:protein heterodimerization activity
2624:. You can help Knowledge (XXG) by
1610:10.1111/j.1600-0528.1976.tb00985.x
1137:
1112:
1086:
1061:
1037:
1018:
992:
973:
947:
928:
691:intracellular anatomical structure
557:
475:
413:
392:
14:
1230:that in humans is encoded by the
751:mitochondrial intermembrane space
686:perinuclear endoplasmic reticulum
2604:
2209:
2194:
2179:
2164:
2159:: CRYSTAL STRUCTURE OF M-CALPAIN
2149:
822:extracellular matrix disassembly
756:external side of plasma membrane
610:cysteine-type peptidase activity
561:
323:
316:
310:
287:
222:
215:
209:
184:
29:
572:More reference expression data
541:More reference expression data
1:
2676:Human chromosome 1 gene stubs
1985:Chua BT, Guo K, Li P (2000).
1871:10.1016/S0022-510X(97)00309-2
1757:Biochem. Biophys. Res. Commun
1644:10.1016/S0021-9258(18)41785-1
1598:Community Dent Oral Epidemiol
1581:10.1016/S1050-1738(01)00112-8
1412:10.1016/S0021-9258(18)83364-6
847:response to hydrogen peroxide
308:
207:
1900:Proc. Natl. Acad. Sci. U.S.A
1509:10.1515/bchm3.1995.376.9.523
620:cytoskeletal protein binding
2681:EF-hand-containing proteins
2671:Genes on human chromosome 1
1224:Calpain-2 catalytic subunit
852:behavioral response to pain
706:cortical actin cytoskeleton
2697:
2599:
2101:gene details page in the
2144:
1970:10.1107/S0907444999013748
1340:"Mouse PubMed Reference:"
1322:"Human PubMed Reference:"
1210:
1205:
1201:
1194:
1178:
1172:Chr 1: 182.29 – 182.35 Mb
1159:
1144:
1119:
1108:
1093:
1068:
1057:
1044:
1040:
1025:
1021:
1012:
999:
995:
980:
976:
967:
954:
950:
935:
931:
922:
907:
900:
896:
880:
590:
586:
569:
560:
551:
538:
487:
478:
429:bronchial epithelial cell
425:
416:
386:
378:
374:
357:
344:
307:
286:
277:
273:
256:
243:
206:
183:
174:
170:
125:
122:
112:
105:
100:
73:
68:
51:
46:
41:
37:
28:
23:
1841:10.1074/jbc.272.52.33377
1738:10.1074/jbc.271.43.27099
1497:Biol. Chem. Hoppe-Seyler
1254:CAPN2 has been shown to
1165:Chr 1: 223.7 – 223.78 Mb
441:mucosa of sigmoid colon
18:Protein found in humans
2004:10.1074/jbc.275.7.5131
1769:10.1006/bbrc.1996.1796
1569:Trends Cardiovasc. Med
1468:10.1074/jbc.M202945200
817:blastocyst development
787:protein autoprocessing
453:metanephric glomerulus
1921:10.1073/pnas.97.2.588
1662:Cytogenet. Cell Genet
726:extracellular exosome
701:endoplasmic reticulum
2095:genome location and
499:facial motor nucleus
302:Chromosome 1 (mouse)
200:Chromosome 1 (human)
69:List of PDB id codes
42:Available structures
2556:Cancer procoagulant
2103:UCSC Genome Browser
2034:2000Natur.405..360L
1962:2000AcCrD..56...73M
1950:Acta Crystallogr. D
1912:2000PNAS...97..588S
1704:10.1021/bi00384a030
1372:10.1021/bi00421a022
782:response to hypoxia
605:calcium ion binding
2612:This article on a
2265:cysteine proteases
2083:2008-04-12 at the
1002:ENSMUSG00000026509
775:Biological process
766:neuronal cell body
659:Cellular component
640:hydrolase activity
625:peptidase activity
598:Molecular function
445:right uterine tube
2633:
2632:
2594:
2593:
2227:
2226:
1731:(43): 27099–106.
1674:10.1159/000132937
1542:10.1042/bj3260001
1524:Cohen GM (1997).
1221:
1220:
1217:
1216:
1190:
1189:
1155:
1154:
1134:
1133:
1104:
1103:
1083:
1082:
1053:
1052:
1034:
1033:
1008:
1007:
989:
988:
963:
962:
944:
943:
892:
891:
615:metal ion binding
582:
581:
578:
577:
547:
546:
534:
533:
472:
471:
370:
369:
269:
268:
164:CAPN2 - orthologs
96:
95:
92:
91:
52:Ortholog search:
2688:
2654:
2647:
2640:
2608:
2601:
2576:3C-like protease
2254:
2247:
2240:
2231:
2213:
2198:
2183:
2168:
2153:
2133:
2126:
2119:
2110:
2061:
2042:10.1038/35012636
2016:
2006:
1981:
1943:
1933:
1923:
1890:
1853:
1843:
1834:(52): 33377–83.
1818:
1787:J. Cell. Biochem
1780:
1750:
1740:
1715:
1685:
1656:
1646:
1621:
1592:
1563:
1553:
1520:
1481:
1480:
1470:
1461:(30): 27217–26.
1445:
1439:
1438:
1431:
1425:
1424:
1414:
1390:
1384:
1383:
1354:
1348:
1347:
1336:
1330:
1329:
1318:
1312:
1302:
1291:
1281:
1203:
1202:
1174:
1167:
1150:
1138:
1129:
1113:
1109:RefSeq (protein)
1099:
1087:
1078:
1062:
1038:
1019:
993:
974:
948:
929:
898:
827:female pregnancy
588:
574:
565:
558:
543:
495:genital tubercle
483:
481:Top expressed in
476:
461:cartilage tissue
433:nasal epithelium
421:
419:Top expressed in
414:
393:
376:
366:
353:
342:
327:
320:
314:
303:
291:
275:
265:
252:
241:
226:
219:
213:
202:
188:
172:
166:
117:
110:
87:
66:
60:
39:
38:
33:
21:
2696:
2695:
2691:
2690:
2689:
2687:
2686:
2685:
2661:
2660:
2659:
2658:
2597:
2595:
2590:
2539:
2472:
2384:
2353:
2275:
2258:
2228:
2223:
2220:
2214:
2205:
2199:
2190:
2184:
2175:
2169:
2160:
2154:
2140:
2137:
2085:Wayback Machine
2069:
2064:
2028:(6784): 360–4.
2019:
1984:
1946:
1893:
1856:
1821:
1783:
1753:
1718:
1698:(10): 2863–70.
1688:
1659:
1637:(27): 19373–8.
1624:
1595:
1566:
1523:
1494:
1490:
1488:Further reading
1485:
1484:
1447:
1446:
1442:
1433:
1432:
1428:
1405:(11): 6404–11.
1392:
1391:
1387:
1356:
1355:
1351:
1338:
1337:
1333:
1320:
1319:
1315:
1303:
1294:
1282:
1273:
1268:
1252:
1243:
1212:View/Edit Mouse
1207:View/Edit Human
1170:
1163:
1160:Location (UCSC)
1146:
1125:
1121:
1095:
1074:
1070:
983:ENSG00000162909
876:
802:myoblast fusion
770:
761:cell projection
746:plasma membrane
666:Golgi apparatus
654:
630:protein binding
570:
539:
530:
525:
523:right lung lobe
521:
517:
513:
509:
505:
501:
497:
493:
479:
468:
465:visceral pleura
463:
459:
457:parietal pleura
455:
451:
447:
443:
439:
435:
431:
417:
361:
348:
340:
330:
329:
328:
321:
301:
278:Gene location (
260:
247:
239:
229:
228:
227:
220:
198:
175:Gene location (
126:
113:
106:
75:
53:
19:
12:
11:
5:
2694:
2692:
2684:
2683:
2678:
2673:
2663:
2662:
2657:
2656:
2649:
2642:
2634:
2631:
2630:
2609:
2592:
2591:
2589:
2588:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2547:
2545:
2541:
2540:
2538:
2537:
2532:
2527:
2522:
2517:
2508:
2503:
2498:
2493:
2488:
2482:
2480:
2474:
2473:
2471:
2470:
2465:
2460:
2455:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2405:
2400:
2394:
2392:
2386:
2385:
2383:
2382:
2377:
2372:
2367:
2361:
2359:
2355:
2354:
2352:
2351:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2285:
2283:
2277:
2276:
2259:
2257:
2256:
2249:
2242:
2234:
2225:
2224:
2222:
2221:
2215:
2208:
2206:
2200:
2193:
2191:
2185:
2178:
2176:
2170:
2163:
2161:
2155:
2148:
2145:
2142:
2141:
2138:
2136:
2135:
2128:
2121:
2113:
2107:
2106:
2087:
2068:
2067:External links
2065:
2063:
2062:
2017:
1982:
1956:(Pt 1): 73–5.
1944:
1891:
1859:J. Neurol. Sci
1854:
1819:
1793:(2): 197–209.
1781:
1763:(1): 299–304.
1751:
1716:
1686:
1657:
1622:
1593:
1564:
1536:(Pt 1): 1–16.
1521:
1491:
1489:
1486:
1483:
1482:
1440:
1426:
1385:
1366:(21): 8122–8.
1349:
1331:
1313:
1292:
1270:
1269:
1267:
1264:
1251:
1248:
1242:
1239:
1219:
1218:
1215:
1214:
1209:
1199:
1198:
1192:
1191:
1188:
1187:
1185:
1183:
1176:
1175:
1168:
1161:
1157:
1156:
1153:
1152:
1142:
1141:
1135:
1132:
1131:
1117:
1116:
1110:
1106:
1105:
1102:
1101:
1091:
1090:
1084:
1081:
1080:
1066:
1065:
1059:
1055:
1054:
1051:
1050:
1042:
1041:
1035:
1032:
1031:
1023:
1022:
1016:
1010:
1009:
1006:
1005:
997:
996:
990:
987:
986:
978:
977:
971:
965:
964:
961:
960:
952:
951:
945:
942:
941:
933:
932:
926:
920:
919:
914:
909:
905:
904:
894:
893:
890:
889:
878:
877:
875:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
778:
776:
772:
771:
769:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
681:focal adhesion
678:
673:
668:
662:
660:
656:
655:
653:
652:
650:enzyme binding
647:
642:
637:
632:
627:
622:
617:
612:
607:
601:
599:
595:
594:
584:
583:
580:
579:
576:
575:
567:
566:
555:
549:
548:
545:
544:
536:
535:
532:
531:
529:
528:
524:
520:
516:
515:tail of embryo
512:
508:
504:
500:
496:
492:
488:
485:
484:
473:
470:
469:
467:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
423:
422:
410:
409:
401:
390:
384:
383:
380:RNA expression
372:
371:
368:
367:
359:
355:
354:
346:
343:
338:
332:
331:
322:
315:
309:
305:
304:
299:
293:
292:
284:
283:
271:
270:
267:
266:
258:
254:
253:
245:
242:
237:
231:
230:
221:
214:
208:
204:
203:
196:
190:
189:
181:
180:
168:
167:
124:
120:
119:
111:
103:
102:
98:
97:
94:
93:
90:
89:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2693:
2682:
2679:
2677:
2674:
2672:
2669:
2668:
2666:
2655:
2650:
2648:
2643:
2641:
2636:
2635:
2629:
2627:
2623:
2619:
2615:
2610:
2607:
2603:
2598:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2546:
2542:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2483:
2481:
2479:
2475:
2469:
2466:
2464:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2395:
2393:
2391:
2387:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2362:
2360:
2358:Fruit-derived
2356:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2286:
2284:
2282:
2278:
2273:
2270:
2266:
2262:
2255:
2250:
2248:
2243:
2241:
2236:
2235:
2232:
2218:
2212:
2207:
2203:
2197:
2192:
2188:
2182:
2177:
2173:
2167:
2162:
2158:
2152:
2147:
2143:
2134:
2129:
2127:
2122:
2120:
2115:
2114:
2111:
2104:
2100:
2099:
2094:
2093:
2088:
2086:
2082:
2079:
2075:
2071:
2070:
2066:
2059:
2055:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2023:
2018:
2014:
2010:
2005:
2000:
1997:(7): 5131–5.
1996:
1992:
1991:J. Biol. Chem
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1945:
1941:
1937:
1932:
1927:
1922:
1917:
1913:
1909:
1906:(2): 588–92.
1905:
1901:
1897:
1892:
1888:
1884:
1880:
1876:
1872:
1868:
1864:
1860:
1855:
1851:
1847:
1842:
1837:
1833:
1829:
1828:J. Biol. Chem
1825:
1820:
1816:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1782:
1778:
1774:
1770:
1766:
1762:
1758:
1752:
1748:
1744:
1739:
1734:
1730:
1726:
1725:J. Biol. Chem
1722:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1658:
1654:
1650:
1645:
1640:
1636:
1632:
1631:J. Biol. Chem
1628:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1594:
1590:
1586:
1582:
1578:
1574:
1570:
1565:
1561:
1557:
1552:
1547:
1543:
1539:
1535:
1531:
1527:
1522:
1518:
1514:
1510:
1506:
1502:
1498:
1493:
1492:
1487:
1478:
1474:
1469:
1464:
1460:
1456:
1455:J. Biol. Chem
1452:
1444:
1441:
1436:
1430:
1427:
1422:
1418:
1413:
1408:
1404:
1400:
1399:J. Biol. Chem
1396:
1389:
1386:
1381:
1377:
1373:
1369:
1365:
1361:
1353:
1350:
1345:
1341:
1335:
1332:
1327:
1323:
1317:
1314:
1310:
1306:
1301:
1299:
1297:
1293:
1289:
1285:
1280:
1278:
1276:
1272:
1265:
1263:
1261:
1257:
1249:
1247:
1240:
1238:
1236:
1233:
1229:
1225:
1213:
1208:
1204:
1200:
1197:
1193:
1186:
1184:
1181:
1177:
1173:
1169:
1166:
1162:
1158:
1151:
1149:
1143:
1139:
1136:
1130:
1128:
1124:
1118:
1114:
1111:
1107:
1100:
1098:
1092:
1088:
1085:
1079:
1077:
1073:
1067:
1063:
1060:
1058:RefSeq (mRNA)
1056:
1049:
1048:
1043:
1039:
1036:
1030:
1029:
1024:
1020:
1017:
1015:
1011:
1004:
1003:
998:
994:
991:
985:
984:
979:
975:
972:
970:
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
918:
915:
913:
910:
906:
903:
899:
895:
888:
884:
879:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
779:
777:
774:
773:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
711:membrane raft
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
602:
600:
597:
596:
593:
592:Gene ontology
589:
585:
573:
568:
564:
559:
556:
554:
550:
542:
537:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
489:
486:
482:
477:
474:
464:
460:
456:
452:
449:parotid gland
448:
444:
440:
436:
432:
428:
427:
424:
420:
415:
412:
411:
408:
406:
402:
400:
399:
395:
394:
391:
389:
385:
381:
377:
373:
365:
360:
356:
352:
347:
337:
333:
326:
319:
313:
306:
298:
294:
290:
285:
281:
276:
272:
264:
259:
255:
251:
246:
236:
232:
225:
218:
212:
205:
201:
195:
191:
187:
182:
178:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
121:
116:
109:
104:
99:
88:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
2626:expanding it
2618:chromosome 1
2611:
2596:
2402:
2216:
2201:
2186:
2171:
2156:
2097:
2091:
2025:
2021:
1994:
1990:
1953:
1949:
1903:
1899:
1865:(2): 163–9.
1862:
1858:
1831:
1827:
1790:
1786:
1760:
1756:
1728:
1724:
1695:
1692:Biochemistry
1691:
1668:(4): 225–9.
1665:
1661:
1634:
1630:
1604:(5): 205–9.
1601:
1597:
1575:(6): 222–9.
1572:
1568:
1533:
1529:
1503:(9): 523–9.
1500:
1496:
1458:
1454:
1443:
1429:
1402:
1398:
1388:
1363:
1360:Biochemistry
1359:
1352:
1343:
1334:
1325:
1316:
1253:
1250:Interactions
1244:
1231:
1223:
1222:
1145:
1123:NP_001139540
1120:
1094:
1072:NM_001146068
1069:
1045:
1026:
1000:
981:
955:
936:
916:
911:
671:pseudopodium
403:
396:
362:182,345,173
349:182,294,825
261:223,776,018
248:223,701,593
123:External IDs
74:
15:
2586:Gingipain K
2581:Gingipain R
2551:Clostripain
2139:PDB gallery
792:proteolysis
341:1|1 H5
101:Identifiers
2665:Categories
2566:Autophagin
2380:Actinidain
2349:Caspase 14
2344:Caspase 13
2339:Caspase 12
2334:Caspase 10
1530:Biochem. J
1311:, May 2017
1290:, May 2017
1266:References
519:right lung
507:belly cord
437:glomerulus
407:(ortholog)
144:HomoloGene
2616:on human
2571:Cruzipain
2478:Cathepsin
2375:Bromelain
2329:Caspase 9
2324:Caspase 8
2319:Caspase 7
2314:Caspase 6
2309:Caspase 5
2304:Caspase 4
2299:Caspase 3
2294:Caspase 2
2289:Caspase 1
2261:Proteases
2058:205006589
1887:205898607
1148:NP_033924
1127:NP_001739
1097:NM_009794
1076:NM_001748
902:Orthologs
741:cytoplasm
716:chromatin
511:left lung
152:GeneCards
2561:Separase
2081:Archived
2050:10830966
2013:10671558
1978:10666632
1940:10639123
1815:85163404
1589:11673052
1477:12000759
1307:–
1286:–
1256:interact
1241:Function
1196:Wikidata
881:Sources:
721:lysosome
696:dendrite
676:membrane
503:gastrula
2390:Calpain
2281:Caspase
2078:C02.002
2030:Bibcode
1958:Bibcode
1908:Bibcode
1879:9562261
1850:9407132
1807:9213221
1777:8954122
1747:8900201
1712:3038169
1682:2209092
1653:1527057
1618:1067155
1560:9337844
1551:1218630
1517:8561910
1421:2539381
1380:2852952
1309:Ensembl
1288:Ensembl
1228:protein
1014:UniProt
969:Ensembl
908:Species
887:QuickGO
736:cytosol
731:nucleus
382:pattern
108:Aliases
2468:CAPNS2
2463:CAPNS1
2458:CAPN14
2453:CAPN13
2448:CAPN12
2443:CAPN11
2438:CAPN10
2370:Ficain
2365:Papain
2272:3.4.22
2089:Human
2074:MEROPS
2056:
2048:
2022:Nature
2011:
1976:
1938:
1928:
1885:
1877:
1848:
1813:
1805:
1775:
1745:
1710:
1680:
1651:
1616:
1587:
1558:
1548:
1515:
1475:
1419:
1378:
1182:search
1180:PubMed
1047:O08529
1028:P17655
924:Entrez
553:BioGPS
527:cornea
132:114230
2620:is a
2544:Other
2433:CAPN9
2428:CAPN8
2423:CAPN7
2418:CAPN6
2413:CAPN5
2408:CAPN3
2403:CAPN2
2398:CAPN1
2098:CAPN2
2092:CAPN2
2054:S2CID
1931:15374
1883:S2CID
1811:S2CID
1260:Bcl-2
1258:with
1232:CAPN2
1226:is a
957:12334
917:Mouse
912:Human
883:Amigo
405:Mouse
398:Human
345:Start
280:Mouse
244:Start
177:Human
156:CAPN2
140:88264
115:CAPN2
24:CAPN2
2622:stub
2614:gene
2217:1u5i
2202:1mdw
2187:1kfx
2172:1kfu
2157:1df0
2072:The
2046:PMID
2009:PMID
1974:PMID
1936:PMID
1875:PMID
1846:PMID
1803:PMID
1773:PMID
1743:PMID
1708:PMID
1678:PMID
1649:PMID
1614:PMID
1585:PMID
1556:PMID
1513:PMID
1473:PMID
1417:PMID
1376:PMID
1235:gene
388:Bgee
336:Band
297:Chr.
240:1q41
235:Band
194:Chr.
148:1326
128:OMIM
85:2NQA
81:1KFX
77:1KFU
58:RCSB
55:PDBe
2038:doi
2026:405
1999:doi
1995:275
1966:doi
1926:PMC
1916:doi
1867:doi
1863:155
1836:doi
1832:272
1795:doi
1765:doi
1761:229
1733:doi
1729:271
1700:doi
1670:doi
1639:doi
1635:267
1606:doi
1577:doi
1546:PMC
1538:doi
1534:326
1505:doi
1501:376
1463:doi
1459:277
1407:doi
1403:264
1368:doi
938:824
358:End
257:End
160:OMA
136:MGI
48:PDB
2667::
2515:L2
2511:L1
2269:EC
2263::
2052:.
2044:.
2036:.
2024:.
2007:.
1993:.
1989:.
1972:.
1964:.
1954:56
1952:.
1934:.
1924:.
1914:.
1904:97
1902:.
1898:.
1881:.
1873:.
1861:.
1844:.
1830:.
1826:.
1809:.
1801:.
1791:66
1789:.
1771:.
1759:.
1741:.
1727:.
1723:.
1706:.
1696:26
1694:.
1676:.
1666:53
1664:.
1647:.
1633:.
1629:.
1612:.
1600:.
1583:.
1573:11
1571:.
1554:.
1544:.
1532:.
1528:.
1511:.
1499:.
1471:.
1457:.
1453:.
1415:.
1401:.
1397:.
1374:.
1364:27
1362:.
1342:.
1324:.
1295:^
1274:^
1262:.
1237:.
885:/
364:bp
351:bp
263:bp
250:bp
158:;
154::
150:;
146::
142:;
138::
134:;
130::
83:,
79:,
2653:e
2646:t
2639:v
2628:.
2535:Z
2530:W
2525:S
2520:O
2513:/
2506:K
2501:H
2496:F
2491:C
2486:B
2274:)
2267:(
2253:e
2246:t
2239:v
2132:e
2125:t
2118:v
2105:.
2060:.
2040::
2032::
2015:.
2001::
1980:.
1968::
1960::
1942:.
1918::
1910::
1889:.
1869::
1852:.
1838::
1817:.
1797::
1779:.
1767::
1749:.
1735::
1714:.
1702::
1684:.
1672::
1655:.
1641::
1620:.
1608::
1602:4
1591:.
1579::
1562:.
1540::
1519:.
1507::
1479:.
1465::
1437:.
1423:.
1409::
1382:.
1370::
1346:.
1328:.
282:)
179:)
162::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.