688:. Those treated in CANTOS had a 15% reduction in deaths from heart attacks, stroke and cardiovascular disease combined. However, there were serious side-effects and no statistically significant overall survival benefit. Although the CANTOS study says, "Overall, canakinumab was tolerated well with essentially identical discontinuation rates compared to placebo. Mild neutropenia and thrombocytopenia were slightly more common in those treated with canakinumab. Rates of death due to infection or sepsis were low but more likely in the canakinumab group compared to placebo (incidence rate 0.31 vs. 0.18 per 100 person-years,
692:= 0.02). In terms of the types of infections that occurred during follow up, only pseudomembranous colitis was more common in the canakinumab group; no evidence of opportunistic infection was observed, data emphasizing that canakinumab is not a clinically immunosuppressive intervention. Further demonstrating this issue, random allocation to canakinumab as compared to placebo in CANTOS resulted in large and highly significant dose-dependent reductions in cancer fatality, incident lung cancer, and fatal lung cancer." Nonetheless, David Goff, director of the division of cardiovascular sciences at the
31:
5245:
1086:
880:
696:
feels the "public health impact potential is really substantial," and estimates that in the United States 3 million people might benefit from canakinumab. Further analysis on data from the CANTOS trial also showed a significant reduction in lung cancer incidence and mortality in the canakinumab
641:
such as redness and pain are common, occurring in approximately 15.5% of cases. The FDA prescribing information for canakinumab (Ilaris) includes a warning for potential increased risk of serious infections due to IL-1 blockade. Macrophage activation syndrome (MAS) is a known, life-threatening
642:
disorder that may develop in people with rheumatic conditions, in particular Still's disease, and should be aggressively treated. Treatment with immunosuppressants may increase the risk of malignancies. People are advised not to receive live vaccinations during treatment.
1046:
1050:
268:
570:
3980:
2915:
223:
487:
857:
563:
3973:
555:
117:
1473:
620:
2908:
604:
60:
3966:
2389:
693:
1075:
5178:
4445:
2901:
600:
543:
516:
834:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
5182:
5168:
5128:
3924:
666:
5270:
5197:
704:(NSAIDs) and colchicine are contraindicated, are not tolerated, or do not provide an adequate response, and in whom repeated courses of
701:
5102:
4050:
2332:
1702:
534:
Common side effects include infections (colds and upper respiratory tract infections), abdominal pain and injection-site reactions.
1466:
781:
2741:
253:
149:
5275:
3896:
685:
608:
574:
569:
In
September 2016, the FDA approved the use of canakinumab for three additional rare and serious auto-inflammatory diseases:
589:
520:
1235:
5265:
5063:
5042:
1205:
1105:"A Systematic Review and Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections"
588:
In June 2020, canakinumab was approved in the United States for the indication to treat active Still's disease, including
5235:
3906:
1538:
1079:
1023:
863:
616:
612:
582:
578:
547:
364:
1047:"Canakinumab (Ilaris) and rilonacept (Arcalyst) approved in EU for treatment of cryopyrin-associated periodic syndrome"
168:
3941:
1647:
1459:
727:"The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β"
1517:
559:
3490:
2195:
819:
551:
1157:
for "Safety, Tolerability and
Efficacy of ACZ885 (Canakinumab) in Patients With Active Rheumatoid Arthritis" at
2575:
700:
In August 2023, the FDA approved canakinumab for the symptomatic treatment of adults with gout flares in whom
681:. In gout, it may result in better outcomes than a low dose of a steroid, but costs five thousand times more.
978:
Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, Leslie KS, Hachulla E, Quartier P, et al. (June 2009).
5021:
4981:
4960:
4904:
4872:
4831:
4789:
4743:
4662:
4636:
4580:
4539:
4513:
4487:
4141:
3929:
2570:
1019:
674:
638:
596:
531:. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
205:
4596:
1317:
Johnson C (27 August 2017). "Major drug study opens up vast new opportunities in combating heart disease".
4456:
4436:
4415:
4334:
4273:
4217:
4171:
4095:
4000:
2375:
1801:
1482:
1440:
782:"Ilaris- canakinumab injection, powder, lyophilized, for solution Ilaris- canakinumab injection, solution"
413:
216:
3002:
2924:
2562:
4106:
5218:
5001:
3989:
3206:
1451:
655:
4131:
4992:
4550:
4345:
4121:
4015:
1783:
1319:
524:
308:
212:
70:
53:
30:
4862:
4857:
4842:
4754:
4733:
4182:
4116:
4075:
4019:
3992:
3391:
3350:
3190:
2982:
2732:
1833:
1187:
1158:
179:
4723:
4591:
4498:
4477:
4228:
4197:
4192:
4136:
4055:
2772:
2630:
4769:
4202:
4030:
4025:
2782:
2468:
1909:
4375:
4360:
4324:
4294:
4040:
3282:
2952:
2893:
2737:
2727:
1528:
1486:
1418:
1367:
1296:
1134:
1001:
928:
756:
281:
99:
39:
5213:
3272:
3262:
2533:
2436:
2099:
1995:
1408:
1398:
1357:
1347:
1286:
1278:
1179:
1124:
1116:
991:
918:
910:
746:
738:
429:
317:
4689:
4685:
4681:
814:
373:
5249:
5005:
3690:
3466:
2832:
2717:
858:"FDA Approves First Treatment for Adult Onset Still's Disease, a Severe and Rare Disease"
1291:
1266:
1129:
1104:
5203:
5193:
5188:
5174:
5160:
5150:
5145:
5092:
5074:
5053:
5032:
5011:
4997:
4971:
4915:
4883:
4847:
4810:
4805:
4800:
4764:
4759:
4673:
4652:
4606:
4555:
4524:
4503:
4238:
4207:
3935:
2722:
2590:
2238:
2072:
2051:
2047:
2043:
1671:
1508:
1413:
1386:
1362:
1335:
923:
898:
751:
726:
705:
662:
659:
35:
5259:
4945:
4601:
4467:
4426:
4350:
4284:
4233:
4187:
4126:
4011:
3845:
3646:
3591:
3516:
3476:
3396:
3290:
2936:
2928:
2872:
2802:
2712:
2619:
2405:
2105:
2027:
1979:
1959:
1817:
1733:
1584:
1550:
1090:
884:
678:
141:
1403:
1191:
5119:
4940:
4626:
4621:
4616:
4365:
4304:
4263:
3835:
3820:
3800:
3790:
3769:
3685:
3626:
3611:
3581:
3561:
3556:
3531:
3511:
3506:
3501:
3451:
3441:
3431:
3381:
3376:
3371:
3300:
3185:
3169:
3072:
3062:
3057:
3032:
2972:
2882:
2842:
2827:
2822:
2538:
2488:
2483:
2463:
2343:
2338:
2201:
2186:
2134:
2110:
2057:
1934:
1924:
1743:
1660:
1655:
1613:
1566:
1523:
1490:
1282:
236:
231:
127:
3958:
1153:
742:
554:(EMA) in October 2009. CAPS is a spectrum of autoinflammatory syndromes including
630:
In August 2023, the FDA expanded coverage to cover the treatment of gout flares.
4950:
4930:
4893:
4728:
4718:
4570:
4565:
4400:
4370:
4309:
4151:
4111:
4070:
3901:
3891:
3830:
3815:
3805:
3795:
3774:
3759:
3744:
3734:
3709:
3662:
3641:
3636:
3631:
3621:
3616:
3601:
3576:
3566:
3546:
3526:
3521:
3486:
3481:
3471:
3461:
3456:
3426:
3416:
3386:
3340:
3335:
3325:
3310:
3295:
3267:
3252:
3237:
3232:
3227:
3195:
3138:
3133:
3123:
3103:
3082:
3077:
3047:
2967:
2877:
2817:
2807:
2797:
2687:
2677:
2672:
2637:
2548:
2543:
2518:
2508:
2498:
2473:
2458:
2453:
2411:
2381:
2367:
2362:
2348:
2291:
2249:
2244:
2230:
2225:
2211:
2191:
2144:
2120:
2078:
2062:
2033:
2017:
1985:
1969:
1964:
1939:
1879:
1874:
1869:
1858:
1848:
1753:
1665:
1623:
1608:
1602:
1598:
1545:
1243:
1020:"Drug Approval Package: Ilaris (canakinumab) Subcutaneous Injection NDA #125319"
135:
1213:
4935:
4925:
4820:
4713:
4708:
4529:
4390:
4380:
4314:
4248:
4161:
4156:
4085:
3861:
3840:
3825:
3810:
3754:
3749:
3729:
3724:
3695:
3669:
3606:
3586:
3571:
3551:
3541:
3496:
3446:
3436:
3411:
3406:
3401:
3366:
3361:
3330:
3315:
3257:
3247:
3242:
3222:
3159:
3154:
3143:
3113:
3108:
3052:
3027:
3012:
2997:
2992:
2962:
2867:
2862:
2847:
2787:
2777:
2762:
2757:
2752:
2702:
2692:
2682:
2647:
2625:
2611:
2523:
2513:
2503:
2493:
2478:
2421:
2416:
2395:
2310:
2305:
2263:
2257:
2158:
2115:
2011:
2001:
1954:
1944:
1919:
1914:
1904:
1899:
1894:
1884:
1843:
1828:
1823:
1807:
1748:
1728:
1677:
1637:
1618:
1560:
1120:
952:
512:
468:
348:
1265:
Sivera F, Wechalekar MD, Andrés M, Buchbinder R, Carmona L (September 2014).
4405:
4395:
4385:
4258:
3764:
3596:
3421:
3320:
3305:
3164:
3128:
3118:
3092:
3087:
3067:
3042:
3037:
3022:
3017:
2987:
2957:
2857:
2852:
2837:
2812:
2767:
2747:
2707:
2642:
2606:
2528:
2324:
2277:
2206:
2172:
2139:
1949:
1929:
1838:
1738:
1578:
1352:
121:
44:
22:
1422:
1371:
1300:
1138:
1005:
932:
914:
760:
996:
979:
4045:
3174:
3097:
3007:
2977:
2792:
2667:
2356:
1864:
1774:
1710:
1632:
651:
328:
163:
1336:"Antiinflammatory Therapy in Clinical Care: The CANTOS Trial and Beyond"
337:
5164:
4647:
3651:
3536:
2285:
658:, but this trial was completed in October 2009. Canakinumab is also in
82:
1076:"FDA approves expanded indications for Ilaris for three rare diseases"
684:
In August 2017, the results of the CANTOS trial were announced at the
4779:
3876:
2600:
2431:
404:
1183:
393:
5086:
5082:
5078:
4697:
4693:
4677:
2299:
2152:
980:"Use of canakinumab in the cryopyrin-associated periodic syndrome"
75:
1089:
This article incorporates text from this source, which is in the
883:
This article incorporates text from this source, which is in the
2271:
2219:
2180:
2166:
1720:
1594:
670:
624:
528:
384:
287:
87:
3962:
2897:
1455:
275:
158:
5154:
2128:
1236:"Canakinumab Add-On Treatment for Schizophrenia (CATS) Study"
605:
tumour necrosis factor receptor associated periodic syndrome
1049:. National electronic Library for Medicines. Archived from
571:
tumor necrosis factor receptor associated periodic syndrome
262:
190:
1387:"Canakinumab and Lung Cancer: Intriguing, but Is It Real?"
564:
Neonatal-Onset
Multisystem Inflammatory Disease (NOMID)
494:
5233:
595:
In the
European Union, canakinumab is indicated for
5138:
5118:
5111:
5062:
5041:
5020:
4980:
4959:
4903:
4871:
4830:
4788:
4742:
4661:
4635:
4579:
4538:
4512:
4486:
4455:
4435:
4414:
4333:
4272:
4216:
4170:
4094:
3999:
3884:
3874:
3854:
3783:
3717:
3708:
3677:
3349:
3281:
3215:
2944:
2935:
2660:
2588:
2561:
2446:
2089:
1791:
1782:
1773:
1766:
1719:
1701:
1692:
1646:
1577:
1507:
1498:
467:
428:
423:
403:
383:
363:
347:
327:
307:
302:
252:
247:
222:
204:
178:
148:
134:
116:
108:
98:
93:
81:
69:
59:
52:
38:of canakinumab (blue) bound to IL-1β (yellow) from
1070:
1068:
951:
776:
774:
772:
770:
852:
850:
848:
846:
844:
842:
840:
1170:Yasothan U, Kar S (2008). "Therapies for COPD".
725:Rondeau JM, Ramage P, Zurini M, Gram H (2015).
316:
556:Familial Cold Autoinflammatory Syndrome (FCAS)
542:Canakinumab was approved for the treatment of
3974:
2909:
1467:
809:
807:
805:
803:
677:(the CANTOS trial). It is also in trials for
8:
708:are not appropriate based on three studies.
167:
21:
1271:The Cochrane Database of Systematic Reviews
295:In general: ℞ (Prescription only)
5115:
3981:
3967:
3959:
3881:
3714:
2941:
2916:
2902:
2894:
1788:
1779:
1770:
1698:
1504:
1474:
1460:
1452:
1103:Kim PJ, Lansang RP, Vender R (July 2023).
953:"FDA Approves Canakinumab for Gout Flares"
946:
944:
942:
29:
1412:
1402:
1361:
1351:
1312:
1310:
1290:
1267:"Interleukin-1 inhibitors for acute gout"
1128:
1109:Journal of Cutaneous Medicine and Surgery
995:
922:
750:
597:autoinflammatory periodic fever syndromes
372:
5146:Interleukin 14 (taxilin alpha, HMW-BCGF)
694:National Heart, Lung and Blood Institute
5240:
717:
601:cryopyrin-associated periodic syndromes
544:cryopyrin-associated periodic syndromes
336:
140:
4444:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
517:systemic juvenile idiopathic arthritis
20:
667:chronic obstructive pulmonary disease
412:
126:
7:
1340:Frontiers in Cardiovascular Medicine
702:nonsteroidal anti-inflammatory drugs
519:, active Still's disease, including
235:
984:The New England Journal of Medicine
697:treated group compared to placebo.
650:Canakinumab was being developed by
392:
1385:Chabner BA, Nabel CS (June 2018).
14:
5243:
1084:
878:
446:
440:
4972:Interleukin 27 (interleukin 30)
1404:10.1634/theoncologist.2018-0116
550:(FDA) in June 2009, and by the
1283:10.1002/14651858.CD009993.pub2
686:European Society of Cardiology
609:hyperimmunoglobulin D syndrome
575:hyperimmunoglobulin D syndrome
458:
452:
434:
1:
868:(Press release). 16 June 2020
743:10.1080/19420862.2015.1081323
523:, gout flares. It is a human
1539:dihydroorotate dehydrogenase
1080:Food and Drug Administration
1024:Food and Drug Administration
864:Food and Drug Administration
665:as a possible treatment for
617:familial Mediterranean fever
613:mevalonate kinase deficiency
583:familial mediterranean fever
579:mevalonate kinase deficiency
548:Food and Drug Administration
507:, sold under the brand name
5271:Drugs developed by Novartis
4322:Antisense oligonucleotides:
1518:purine synthesis inhibitors
1334:Aday AW, Ridker PM (2018).
590:adult-onset Still's disease
560:Muckle–Wells syndrome (MWS)
521:adult-onset Still's disease
5292:
424:Chemical and physical data
3919:
1703:IL-1 receptor antagonists
1445:National Cancer Institute
1121:10.1177/12034754231188444
1082:(FDA). 23 September 2016.
1045:Wan Y (29 October 2009).
820:European Medicines Agency
552:European Medicines Agency
484:
28:
2576:Anti-lymphocyte globulin
639:Injection site reactions
5012:Interleukin-29 (IFN-λ1)
4157:Daclizumab (dacliximab)
4142:Tucotuzumab celmoleukin
2571:Anti-thymocyte globulin
1483:Immunosuppressive drugs
1353:10.3389/fcvm.2018.00062
675:coronary artery disease
4993:Interferon λ4 (IFN-λ4)
4086:Rilonacept (IL-1 Trap)
2376:Interleukin-6 receptor
1802:Complement component 5
1151:Clinical trial number
1078:(Press release). U.S.
915:10.4161/mabs.2.1.10328
5276:Monoclonal antibodies
4916:Interleukin 23 (SGRF)
4597:Cintredekin besudotox
4525:Interleukin 11 (AGIF)
4504:Interleukin 10 (CSIF)
3003:Camidanlumab tesirine
2925:Monoclonal antibodies
1026:(FDA). 26 August 2009
997:10.1056/NEJMoa0810787
654:for the treatment of
515:for the treatment of
5266:Antineoplastic drugs
3990:Interleukin receptor
3678:Chimeric + humanized
3207:Nivolumab/relatlimab
656:rheumatoid arthritis
4122:Denileukin diftitox
1320:The Washington Post
1172:Nat Rev Drug Discov
897:Dhimolea E (2010).
824:. 17 September 2018
788:. 14 September 2019
546:(CAPS) by the U.S.
525:monoclonal antibody
271:(Prescription only)
54:Monoclonal antibody
25:
16:Pharmaceutical drug
4694:E (interleukin 25)
3946:Never to phase III
3392:Certolizumab pegol
3359:Immunosuppressive:
2733:Diroximel fumarate
2406:IL-2 receptor/CD25
1834:Certolizumab pegol
1487:Immunosuppressants
1246:on 4 November 2016
1216:on 15 October 2017
1159:ClinicalTrials.gov
529:interleukin-1 beta
5231:
5230:
5227:
5226:
5196:(signals through
5177:(signals through
5163:(signals through
5153:(signals through
4777:Binding proteins:
4107:Adargileukin alfa
3956:
3955:
3915:
3914:
3870:
3869:
3704:
3703:
3659:Immune activation
3151:Immune activation
2953:Immunosuppression
2891:
2890:
2738:Efgartigimod alfa
2728:Dimethyl fumarate
2656:
2655:
2584:
2583:
2557:
2556:
1762:
1761:
1688:
1687:
1529:Mycophenolic acid
1053:on 2 October 2011
990:(23): 2416–2425.
502:
501:
291:
279:
266:
194:
161:
5283:
5248:
5247:
5246:
5239:
5219:Efineptakin alfa
5214:Efavaleukin alfa
5116:
4083:Decoy receptors:
3983:
3976:
3969:
3960:
3882:
3715:
3273:Zolimomab aritox
3263:Telimomab aritox
2942:
2918:
2911:
2904:
2895:
2534:Telimomab aritox
2437:Zolimomab aritox
2258:CD62L/L-selectin
1996:Immunoglobulin E
1789:
1780:
1771:
1699:
1505:
1476:
1469:
1462:
1453:
1448:
1427:
1426:
1416:
1406:
1382:
1376:
1375:
1365:
1355:
1331:
1325:
1324:
1314:
1305:
1304:
1294:
1262:
1256:
1255:
1253:
1251:
1242:. Archived from
1232:
1226:
1225:
1223:
1221:
1212:. Archived from
1206:"CANTOS Summary"
1202:
1196:
1195:
1167:
1161:
1149:
1143:
1142:
1132:
1100:
1094:
1088:
1087:
1083:
1072:
1063:
1062:
1060:
1058:
1042:
1036:
1035:
1033:
1031:
1016:
1010:
1009:
999:
975:
969:
968:
966:
964:
955:
948:
937:
936:
926:
894:
888:
882:
881:
877:
875:
873:
854:
835:
833:
831:
829:
811:
798:
797:
795:
793:
778:
765:
764:
754:
737:(6): 1151–1160.
722:
498:
497:
490:
479:
477:
460:
454:
448:
442:
436:
416:
396:
376:
340:
320:
289:
286:
277:
274:
264:
261:
239:
192:
189:
171:
160:
157:
144:
130:
47:
33:
26:
24:
5291:
5290:
5286:
5285:
5284:
5282:
5281:
5280:
5256:
5255:
5254:
5244:
5242:
5234:
5232:
5223:
5134:
5107:
5058:
5037:
5016:
4976:
4955:
4899:
4896:(against IL-22)
4867:
4826:
4823:(against IL-20)
4784:
4738:
4657:
4631:
4575:
4534:
4508:
4482:
4451:
4431:
4410:
4329:
4268:
4212:
4166:
4090:
3995:
3987:
3957:
3952:
3951:
3936:Clinical trials
3911:
3866:
3850:
3779:
3700:
3691:Rozanolixizumab
3679:
3673:
3665:
3654:
3467:Lulizumab pegol
3345:
3277:
3211:
2931:
2922:
2892:
2887:
2833:Rozanolixizumab
2718:Deucravacitinib
2652:
2580:
2553:
2442:
2091:
2085:
1793:
1758:
1715:
1694:
1684:
1642:
1582:
1573:
1509:Antimetabolites
1500:
1494:
1480:
1439:
1436:
1431:
1430:
1384:
1383:
1379:
1333:
1332:
1328:
1316:
1315:
1308:
1277:(9): CD009993.
1264:
1263:
1259:
1249:
1247:
1234:
1233:
1229:
1219:
1217:
1204:
1203:
1199:
1184:10.1038/nrd2533
1169:
1168:
1164:
1150:
1146:
1102:
1101:
1097:
1085:
1074:
1073:
1066:
1056:
1054:
1044:
1043:
1039:
1029:
1027:
1018:
1017:
1013:
977:
976:
972:
962:
960:
950:
949:
940:
896:
895:
891:
879:
871:
869:
856:
855:
838:
827:
825:
813:
812:
801:
791:
789:
780:
779:
768:
724:
723:
719:
714:
706:corticosteroids
663:clinical trials
648:
636:
634:Adverse effects
625:gouty arthritis
621:Still's disease
540:
493:
491:
488:(what is this?)
485:
475:
473:
463:
457:
451:
445:
439:
419:
399:
379:
359:
343:
323:
298:
243:
207:
200:
181:
174:
112:ACZ885, ACZ-885
48:
43:
17:
12:
11:
5:
5289:
5287:
5279:
5278:
5273:
5268:
5258:
5257:
5253:
5252:
5229:
5228:
5225:
5224:
5222:
5221:
5216:
5207:
5206:
5204:Interleukin 35
5201:
5194:Interleukin 34
5191:
5189:Interleukin 32
5186:
5175:Interleukin 26
5172:
5161:Interleukin 24
5158:
5151:Interleukin 16
5148:
5142:
5140:
5136:
5135:
5133:
5132:
5124:
5122:
5113:
5109:
5108:
5106:
5105:
5096:
5095:
5093:Interleukin 38
5090:
5075:Interleukin 36
5068:
5066:
5060:
5059:
5057:
5056:
5054:Interleukin 33
5047:
5045:
5039:
5038:
5036:
5035:
5033:Interleukin 31
5026:
5024:
5018:
5017:
5015:
5014:
5009:
4998:Interleukin 28
4995:
4986:
4984:
4978:
4977:
4975:
4974:
4965:
4963:
4957:
4956:
4954:
4953:
4948:
4943:
4938:
4933:
4928:
4919:
4918:
4909:
4907:
4901:
4900:
4898:
4897:
4887:
4886:
4884:Interleukin 22
4877:
4875:
4869:
4868:
4866:
4865:
4860:
4851:
4850:
4848:Interleukin 21
4845:
4836:
4834:
4828:
4827:
4825:
4824:
4814:
4813:
4811:Interleukin 24
4808:
4806:Interleukin 20
4803:
4801:Interleukin 19
4794:
4792:
4786:
4785:
4783:
4782:
4773:
4772:
4767:
4765:Interleukin 37
4762:
4760:Interleukin 18
4757:
4748:
4746:
4740:
4739:
4737:
4736:
4731:
4726:
4721:
4716:
4711:
4702:
4701:
4674:Interleukin 17
4667:
4665:
4659:
4658:
4656:
4655:
4653:Interleukin 15
4650:
4641:
4639:
4633:
4632:
4630:
4629:
4624:
4619:
4610:
4609:
4607:Interleukin 13
4604:
4599:
4594:
4585:
4583:
4577:
4576:
4574:
4573:
4568:
4559:
4558:
4556:Interleukin 12
4553:
4544:
4542:
4536:
4535:
4533:
4532:
4527:
4518:
4516:
4510:
4509:
4507:
4506:
4501:
4492:
4490:
4484:
4483:
4481:
4480:
4471:
4470:
4461:
4459:
4453:
4452:
4450:
4449:
4441:
4439:
4433:
4432:
4430:
4429:
4420:
4418:
4412:
4411:
4409:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4354:
4353:
4348:
4339:
4337:
4331:
4330:
4328:
4327:
4318:
4317:
4312:
4307:
4298:
4297:
4288:
4287:
4278:
4276:
4270:
4269:
4267:
4266:
4261:
4252:
4251:
4242:
4241:
4239:Interleukin 13
4236:
4231:
4222:
4220:
4214:
4213:
4211:
4210:
4208:Promegapoietin
4205:
4200:
4195:
4190:
4185:
4176:
4174:
4168:
4167:
4165:
4164:
4159:
4154:
4145:
4144:
4139:
4134:
4132:Pegaldesleukin
4129:
4124:
4119:
4114:
4109:
4100:
4098:
4092:
4091:
4089:
4088:
4079:
4078:
4073:
4068:
4059:
4058:
4053:
4048:
4043:
4034:
4033:
4028:
4023:
4005:
4003:
3997:
3996:
3988:
3986:
3985:
3978:
3971:
3963:
3954:
3953:
3950:
3949:
3948:
3947:
3944:
3933:
3927:
3921:
3920:
3917:
3916:
3913:
3912:
3910:
3909:
3904:
3899:
3894:
3888:
3886:
3879:
3872:
3871:
3868:
3867:
3865:
3864:
3858:
3856:
3852:
3851:
3849:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3787:
3785:
3781:
3780:
3778:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3721:
3719:
3712:
3706:
3705:
3702:
3701:
3699:
3698:
3693:
3688:
3682:
3680:
3675:
3674:
3656:
3655:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3491:+hyaluronidase
3484:
3479:
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3355:
3353:
3347:
3346:
3344:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3287:
3285:
3279:
3278:
3276:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3219:
3217:
3213:
3212:
3210:
3209:
3199:
3198:
3193:
3188:
3178:
3177:
3172:
3167:
3162:
3157:
3147:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2948:
2946:
2939:
2933:
2932:
2923:
2921:
2920:
2913:
2906:
2898:
2889:
2888:
2886:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2742:+hyaluronidase
2735:
2730:
2725:
2723:Deuruxolitinib
2720:
2715:
2710:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2670:
2664:
2662:
2658:
2657:
2654:
2653:
2651:
2650:
2645:
2640:
2635:
2634:
2633:
2628:
2616:
2615:
2614:
2609:
2596:
2594:
2586:
2585:
2582:
2581:
2579:
2578:
2573:
2567:
2565:
2559:
2558:
2555:
2554:
2552:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2450:
2448:
2444:
2443:
2441:
2440:
2427:
2426:
2425:
2424:
2419:
2414:
2401:
2400:
2399:
2398:
2386:
2385:
2384:
2372:
2371:
2370:
2365:
2353:
2352:
2351:
2346:
2341:
2329:
2328:
2327:
2316:
2315:
2314:
2313:
2308:
2296:
2295:
2294:
2282:
2281:
2280:
2268:
2267:
2266:
2254:
2253:
2252:
2247:
2235:
2234:
2233:
2228:
2216:
2215:
2214:
2209:
2204:
2199:
2196:+hyaluronidase
2189:
2177:
2176:
2175:
2163:
2162:
2161:
2149:
2148:
2147:
2142:
2137:
2125:
2124:
2123:
2118:
2113:
2108:
2095:
2093:
2087:
2086:
2084:
2083:
2082:
2081:
2068:
2067:
2066:
2065:
2060:
2039:
2038:
2037:
2036:
2023:
2022:
2021:
2020:
2007:
2006:
2005:
2004:
1991:
1990:
1989:
1988:
1975:
1974:
1973:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1937:
1932:
1927:
1922:
1917:
1912:
1907:
1902:
1897:
1892:
1887:
1882:
1877:
1872:
1867:
1854:
1853:
1852:
1851:
1846:
1841:
1836:
1831:
1826:
1813:
1812:
1811:
1810:
1797:
1795:
1786:
1777:
1768:
1764:
1763:
1760:
1759:
1757:
1756:
1751:
1746:
1741:
1736:
1731:
1725:
1723:
1717:
1716:
1714:
1713:
1707:
1705:
1696:
1690:
1689:
1686:
1685:
1683:
1682:
1681:
1680:
1672:PDE4 inhibitor
1668:
1663:
1658:
1652:
1650:
1644:
1643:
1641:
1640:
1635:
1629:
1628:
1627:
1626:
1621:
1616:
1611:
1590:
1588:
1575:
1574:
1572:
1571:
1570:
1569:
1556:
1555:
1554:
1553:
1548:
1534:
1533:
1532:
1531:
1526:
1513:
1511:
1502:
1496:
1495:
1481:
1479:
1478:
1471:
1464:
1456:
1450:
1449:
1435:
1434:External links
1432:
1429:
1428:
1397:(6): 637–638.
1391:The Oncologist
1377:
1326:
1306:
1257:
1227:
1197:
1162:
1144:
1115:(4): 358–367.
1095:
1064:
1037:
1011:
970:
938:
889:
836:
799:
766:
716:
715:
713:
710:
647:
644:
635:
632:
539:
536:
500:
499:
482:
481:
471:
465:
464:
461:
455:
449:
443:
437:
432:
426:
425:
421:
420:
418:
417:
409:
407:
401:
400:
398:
397:
389:
387:
381:
380:
378:
377:
369:
367:
361:
360:
358:
357:
353:
351:
345:
344:
342:
341:
333:
331:
325:
324:
322:
321:
313:
311:
305:
304:
300:
299:
297:
296:
293:
284:
272:
258:
256:
250:
249:
245:
244:
242:
241:
228:
226:
220:
219:
210:
208:administration
202:
201:
199:
198:
196:
186:
184:
176:
175:
173:
172:
154:
152:
146:
145:
138:
132:
131:
124:
114:
113:
110:
106:
105:
102:
96:
95:
91:
90:
85:
79:
78:
73:
67:
66:
65:Whole antibody
63:
57:
56:
50:
49:
36:Ribbon diagram
34:
15:
13:
10:
9:
6:
4:
3:
2:
5288:
5277:
5274:
5272:
5269:
5267:
5264:
5263:
5261:
5251:
5241:
5237:
5220:
5217:
5215:
5212:
5209:
5208:
5205:
5202:
5199:
5195:
5192:
5190:
5187:
5184:
5180:
5176:
5173:
5170:
5166:
5162:
5159:
5156:
5152:
5149:
5147:
5144:
5143:
5141:
5137:
5130:
5126:
5125:
5123:
5121:
5117:
5114:
5110:
5104:
5101:
5098:
5097:
5094:
5091:
5088:
5084:
5080:
5076:
5073:
5070:
5069:
5067:
5065:
5061:
5055:
5052:
5049:
5048:
5046:
5044:
5040:
5034:
5031:
5028:
5027:
5025:
5023:
5019:
5013:
5010:
5007:
5003:
4999:
4996:
4994:
4991:
4988:
4987:
4985:
4983:
4979:
4973:
4970:
4967:
4966:
4964:
4962:
4958:
4952:
4949:
4947:
4946:Tildrakizumab
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4921:
4920:
4917:
4914:
4911:
4910:
4908:
4906:
4902:
4895:
4892:
4889:
4888:
4885:
4882:
4879:
4878:
4876:
4874:
4870:
4864:
4861:
4859:
4856:
4853:
4852:
4849:
4846:
4844:
4841:
4838:
4837:
4835:
4833:
4829:
4822:
4819:
4816:
4815:
4812:
4809:
4807:
4804:
4802:
4799:
4796:
4795:
4793:
4791:
4787:
4781:
4778:
4775:
4774:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4750:
4749:
4747:
4745:
4741:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4704:
4703:
4699:
4695:
4691:
4687:
4683:
4679:
4675:
4672:
4669:
4668:
4666:
4664:
4660:
4654:
4651:
4649:
4646:
4643:
4642:
4640:
4638:
4634:
4628:
4625:
4623:
4620:
4618:
4615:
4612:
4611:
4608:
4605:
4603:
4602:Interleukin 4
4600:
4598:
4595:
4593:
4590:
4587:
4586:
4584:
4582:
4578:
4572:
4569:
4567:
4564:
4561:
4560:
4557:
4554:
4552:
4551:Edodekin alfa
4549:
4546:
4545:
4543:
4541:
4537:
4531:
4528:
4526:
4523:
4520:
4519:
4517:
4515:
4511:
4505:
4502:
4500:
4497:
4494:
4493:
4491:
4489:
4485:
4479:
4476:
4473:
4472:
4469:
4468:Interleukin 9
4466:
4463:
4462:
4460:
4458:
4454:
4447:
4443:
4442:
4440:
4438:
4434:
4428:
4427:Interleukin 7
4425:
4422:
4421:
4419:
4417:
4413:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4356:
4355:
4352:
4351:Interleukin 6
4349:
4347:
4346:Atexakin alfa
4344:
4341:
4340:
4338:
4336:
4332:
4326:
4323:
4320:
4319:
4316:
4313:
4311:
4308:
4306:
4303:
4300:
4299:
4296:
4293:
4290:
4289:
4286:
4285:Interleukin 5
4283:
4280:
4279:
4277:
4275:
4271:
4265:
4262:
4260:
4257:
4254:
4253:
4250:
4247:
4244:
4243:
4240:
4237:
4235:
4234:Interleukin 4
4232:
4230:
4227:
4224:
4223:
4221:
4219:
4215:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4188:Interleukin 3
4186:
4184:
4181:
4178:
4177:
4175:
4173:
4169:
4163:
4160:
4158:
4155:
4153:
4150:
4147:
4146:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4127:Interleukin 2
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4102:
4101:
4099:
4097:
4093:
4087:
4084:
4081:
4080:
4077:
4074:
4072:
4069:
4067:
4064:
4061:
4060:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4036:
4035:
4032:
4029:
4027:
4024:
4021:
4017:
4013:
4012:Interleukin 1
4010:
4007:
4006:
4004:
4002:
3998:
3994:
3991:
3984:
3979:
3977:
3972:
3970:
3965:
3964:
3961:
3945:
3943:
3940:
3939:
3937:
3934:
3931:
3928:
3926:
3923:
3922:
3918:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3889:
3887:
3883:
3880:
3878:
3875:Inflammatory
3873:
3863:
3860:
3859:
3857:
3853:
3847:
3846:Tildrakizumab
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3788:
3786:
3782:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3722:
3720:
3716:
3713:
3711:
3707:
3697:
3694:
3692:
3689:
3687:
3684:
3683:
3681:
3676:
3672:
3671:
3668:
3664:
3660:
3653:
3650:
3648:
3647:Vobarilizumab
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3592:Spartalizumab
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3517:Pembrolizumab
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3492:
3488:
3485:
3483:
3480:
3478:
3477:Mogamulizumab
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3397:Crizanlizumab
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3357:
3356:
3354:
3352:
3348:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3291:Andecaliximab
3289:
3288:
3286:
3284:
3280:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3220:
3218:
3214:
3208:
3204:
3201:
3200:
3197:
3194:
3192:
3189:
3187:
3183:
3180:
3179:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3152:
3149:
3148:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2955:
2954:
2950:
2949:
2947:
2943:
2940:
2938:
2937:Immune system
2934:
2930:
2929:immune system
2926:
2919:
2914:
2912:
2907:
2905:
2900:
2899:
2896:
2884:
2881:
2879:
2876:
2874:
2873:Tildrakizumab
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2803:Pegcetacoplan
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2743:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2713:Darvadstrocel
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2665:
2663:
2659:
2649:
2646:
2644:
2641:
2639:
2636:
2632:
2629:
2627:
2624:
2623:
2622:
2621:
2620:TNF inhibitor
2617:
2613:
2610:
2608:
2605:
2604:
2603:
2602:
2598:
2597:
2595:
2592:
2587:
2577:
2574:
2572:
2569:
2568:
2566:
2564:
2560:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2451:
2449:
2445:
2438:
2434:
2433:
2429:
2428:
2423:
2420:
2418:
2415:
2413:
2410:
2409:
2408:
2407:
2403:
2402:
2397:
2394:
2393:
2392:
2391:
2387:
2383:
2380:
2379:
2378:
2377:
2373:
2369:
2366:
2364:
2361:
2360:
2359:
2358:
2354:
2350:
2347:
2345:
2342:
2340:
2337:
2336:
2335:
2334:
2330:
2326:
2323:
2322:
2321:
2318:
2317:
2312:
2309:
2307:
2304:
2303:
2302:
2301:
2297:
2293:
2290:
2289:
2288:
2287:
2286:CD147/Basigin
2283:
2279:
2276:
2275:
2274:
2273:
2269:
2265:
2262:
2261:
2260:
2259:
2255:
2251:
2248:
2246:
2243:
2242:
2241:
2240:
2236:
2232:
2229:
2227:
2224:
2223:
2222:
2221:
2217:
2213:
2210:
2208:
2205:
2203:
2200:
2197:
2193:
2190:
2188:
2185:
2184:
2183:
2182:
2178:
2174:
2171:
2170:
2169:
2168:
2164:
2160:
2157:
2156:
2155:
2154:
2150:
2146:
2143:
2141:
2138:
2136:
2133:
2132:
2131:
2130:
2126:
2122:
2119:
2117:
2114:
2112:
2109:
2107:
2106:Muromonab-CD3
2104:
2103:
2102:
2101:
2097:
2096:
2094:
2088:
2080:
2077:
2076:
2075:
2074:
2070:
2069:
2064:
2061:
2059:
2056:
2055:
2054:
2053:
2049:
2045:
2041:
2040:
2035:
2032:
2031:
2030:
2029:
2025:
2024:
2019:
2016:
2015:
2014:
2013:
2009:
2008:
2003:
2000:
1999:
1998:
1997:
1993:
1992:
1987:
1984:
1983:
1982:
1981:
1980:Interleukin 5
1977:
1976:
1971:
1968:
1966:
1963:
1961:
1960:Tildrakizumab
1958:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1931:
1928:
1926:
1923:
1921:
1918:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1862:
1861:
1860:
1856:
1855:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1821:
1820:
1819:
1815:
1814:
1809:
1806:
1805:
1804:
1803:
1799:
1798:
1796:
1794:(noncellular)
1790:
1787:
1785:
1781:
1778:
1776:
1772:
1769:
1767:Extracellular
1765:
1755:
1752:
1750:
1747:
1745:
1742:
1740:
1737:
1735:
1734:Ridaforolimus
1732:
1730:
1727:
1726:
1724:
1722:
1718:
1712:
1709:
1708:
1706:
1704:
1700:
1697:
1693:Intracellular
1691:
1679:
1676:
1675:
1674:
1673:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1653:
1651:
1649:
1645:
1639:
1636:
1634:
1631:
1630:
1625:
1622:
1620:
1617:
1615:
1612:
1610:
1607:
1606:
1605:
1604:
1600:
1596:
1592:
1591:
1589:
1586:
1580:
1576:
1568:
1565:
1564:
1563:
1562:
1558:
1557:
1552:
1551:Teriflunomide
1549:
1547:
1544:
1543:
1541:
1540:
1536:
1535:
1530:
1527:
1525:
1522:
1521:
1520:
1519:
1515:
1514:
1512:
1510:
1506:
1503:
1499:Intracellular
1497:
1492:
1488:
1484:
1477:
1472:
1470:
1465:
1463:
1458:
1457:
1454:
1446:
1442:
1441:"Canakinumab"
1438:
1437:
1433:
1424:
1420:
1415:
1410:
1405:
1400:
1396:
1392:
1388:
1381:
1378:
1373:
1369:
1364:
1359:
1354:
1349:
1345:
1341:
1337:
1330:
1327:
1322:
1321:
1313:
1311:
1307:
1302:
1298:
1293:
1288:
1284:
1280:
1276:
1272:
1268:
1261:
1258:
1245:
1241:
1237:
1231:
1228:
1215:
1211:
1210:theCANTOS.org
1207:
1201:
1198:
1193:
1189:
1185:
1181:
1177:
1173:
1166:
1163:
1160:
1156:
1155:
1148:
1145:
1140:
1136:
1131:
1126:
1122:
1118:
1114:
1110:
1106:
1099:
1096:
1092:
1091:public domain
1081:
1077:
1071:
1069:
1065:
1052:
1048:
1041:
1038:
1025:
1021:
1015:
1012:
1007:
1003:
998:
993:
989:
985:
981:
974:
971:
959:
954:
947:
945:
943:
939:
934:
930:
925:
920:
916:
912:
908:
904:
900:
899:"Canakinumab"
893:
890:
886:
885:public domain
867:
865:
859:
853:
851:
849:
847:
845:
843:
841:
837:
823:
821:
816:
815:"Ilaris EPAR"
810:
808:
806:
804:
800:
787:
783:
777:
775:
773:
771:
767:
762:
758:
753:
748:
744:
740:
736:
732:
728:
721:
718:
711:
709:
707:
703:
698:
695:
691:
687:
682:
680:
679:schizophrenia
676:
672:
668:
664:
661:
657:
653:
645:
643:
640:
633:
631:
628:
626:
622:
618:
614:
610:
606:
602:
598:
593:
591:
586:
584:
580:
576:
572:
567:
565:
561:
557:
553:
549:
545:
537:
535:
532:
530:
526:
522:
518:
514:
510:
506:
496:
489:
483:
472:
470:
466:
433:
431:
427:
422:
415:
414:ChEMBL1201834
411:
410:
408:
406:
402:
395:
391:
390:
388:
386:
382:
375:
371:
370:
368:
366:
362:
355:
354:
352:
350:
346:
339:
335:
334:
332:
330:
326:
319:
315:
314:
312:
310:
306:
301:
294:
292: Rx-only
285:
283:
273:
270:
260:
259:
257:
255:
251:
246:
238:
233:
230:
229:
227:
225:
221:
218:
214:
211:
209:
203:
197:
188:
187:
185:
183:
177:
170:
165:
156:
155:
153:
151:
147:
143:
139:
137:
133:
129:
125:
123:
119:
115:
111:
107:
103:
101:
97:
94:Clinical data
92:
89:
86:
84:
80:
77:
74:
72:
68:
64:
62:
58:
55:
51:
46:
41:
37:
32:
27:
19:
5210:
5198:M-CSFR/CSF1R
5185:heterodimer)
5171:heterodimer)
5100:Antagonists:
5099:
5071:
5050:
5029:
4989:
4968:
4941:Risankizumab
4922:
4912:
4890:
4880:
4863:NNC0114-0006
4858:NNC0114-0005
4854:
4839:
4817:
4797:
4776:
4751:
4705:
4670:
4644:
4627:Tralokinumab
4622:Lebrikizumab
4617:Anrukinzumab
4613:
4588:
4562:
4547:
4521:
4495:
4474:
4464:
4423:
4366:Clazakizumab
4357:
4342:
4321:
4305:Benralizumab
4301:
4292:Antagonists:
4291:
4281:
4264:Pascolizumab
4255:
4246:Antagonists:
4245:
4225:
4179:
4148:
4103:
4082:
4065:
4062:
4038:Antagonists:
4037:
4008:
3836:Risankizumab
3821:Lebrikizumab
3801:Clazakizumab
3791:Anrukinzumab
3770:Tralokinumab
3739:
3686:Otelixizumab
3666:
3658:
3657:
3627:Tregalizumab
3612:Tislelizumab
3582:Satralizumab
3562:Rontalizumab
3557:Retifanlimab
3532:Plozalizumab
3512:Pateclizumab
3507:Pascolizumab
3502:Ozoralizumab
3452:Lampalizumab
3442:Inebilizumab
3432:Fontolizumab
3382:Camrelizumab
3377:Benralizumab
3372:Atezolizumab
3358:
3301:Clenoliximab
3202:
3186:Bertilimumab
3181:
3170:Tremelimumab
3150:
3073:Mavrilimumab
3063:Lirentelimab
3058:Lerdelimumab
3033:Fresolimumab
2973:Atorolimumab
2951:
2883:Upadacitinib
2843:Satralizumab
2828:Ritlecitinib
2823:Risankizumab
2697:
2618:
2599:
2539:Teprotumumab
2489:Inebilizumab
2484:Fontolizumab
2464:Atorolimumab
2432:T-lymphocyte
2430:
2404:
2388:
2374:
2355:
2344:Lerdelimumab
2339:Bertilimumab
2331:
2319:
2298:
2284:
2270:
2256:
2237:
2218:
2202:Pascolizumab
2187:Obinutuzumab
2179:
2165:
2151:
2135:Clenoliximab
2127:
2111:Otelixizumab
2098:
2071:
2058:Lebrikizumab
2042:
2026:
2010:
1994:
1978:
1935:Satralizumab
1925:Risankizumab
1889:
1857:
1816:
1800:
1792:Serum target
1744:Temsirolimus
1670:
1661:Pomalidomide
1656:Lenalidomide
1614:Pimecrolimus
1593:
1567:Methotrexate
1559:
1537:
1524:Azathioprine
1516:
1501:(initiation)
1444:
1394:
1390:
1380:
1343:
1339:
1329:
1318:
1274:
1270:
1260:
1248:. Retrieved
1244:the original
1239:
1230:
1218:. Retrieved
1214:the original
1209:
1200:
1175:
1171:
1165:
1152:
1147:
1112:
1108:
1098:
1055:. Retrieved
1051:the original
1040:
1028:. Retrieved
1014:
987:
983:
973:
961:. Retrieved
957:
906:
902:
892:
870:. Retrieved
861:
826:. Retrieved
818:
790:. Retrieved
785:
734:
730:
720:
699:
689:
683:
649:
637:
629:
594:
587:
568:
541:
538:Medical uses
533:
527:targeted at
508:
504:
503:
492:
486:
254:Legal status
248:Legal status
217:subcutaneous
150:License data
18:
4951:Ustekinumab
4931:Briakinumab
4923:Antibodies:
4894:Fezakinumab
4891:Antibodies:
4855:Antibodies:
4843:Denenicokin
4818:Antibodies:
4755:Iboctadekin
4734:Vunakizumab
4729:Secukinumab
4719:Perakizumab
4706:Antibodies:
4614:Antibodies:
4571:Ustekinumab
4566:Briakinumab
4563:Antibodies:
4475:Antibodies:
4401:Tocilizumab
4371:Elsilimomab
4358:Antibodies:
4310:Mepolizumab
4302:Antibodies:
4256:Antibodies:
4183:Daniplestim
4152:Basiliximab
4149:Antibodies:
4117:Celmoleukin
4112:Aldesleukin
4076:Lutikizumab
4071:Gevokizumab
4066:Canakinumab
4063:Antibodies:
3932:from market
3902:Lemalesomab
3897:Fanolesomab
3892:Besilesomab
3831:Perakizumab
3816:Mirikizumab
3806:Gevokizumab
3796:Bimekizumab
3775:Ustekinumab
3760:Secukinumab
3745:Fezakinumab
3740:Canakinumab
3735:Briakinumab
3710:Interleukin
3663:Dostarlimab
3642:Visilizumab
3637:Vedolizumab
3632:Vatelizumab
3622:Toralizumab
3617:Tocilizumab
3602:Teclistamab
3577:Samalizumab
3567:Rovelizumab
3547:Ravulizumab
3527:Pidilizumab
3522:Pexelizumab
3487:Ocrelizumab
3482:Natalizumab
3472:Mepolizumab
3462:Ligelizumab
3457:Letolizumab
3427:Etrolizumab
3417:Epratuzumab
3387:Cedelizumab
3341:Vapaliximab
3336:Teneliximab
3326:Lumiliximab
3311:Gomiliximab
3296:Basiliximab
3268:Vepalimomab
3253:Nerelimomab
3238:Gavilimomab
3233:Faralimomab
3228:Elsilimomab
3203:Combination
3196:Zanolimumab
3191:Ontamalimab
3139:Ulocuplumab
3134:Tezepelumab
3124:Sifalimumab
3104:Pamrevlumab
3083:Morolimumab
3078:Metelimumab
3048:Lanadelumab
2983:Avdoralimab
2968:Anifrolumab
2878:Tofacitinib
2818:Ravulizumab
2808:Pirfenidone
2798:Peficitinib
2698:Canakinumab
2688:Briakinumab
2678:Bimekizumab
2673:Baricitinib
2638:Aflibercept
2549:Vepalimomab
2544:Vapaliximab
2519:Rovelizumab
2509:Pexelizumab
2499:Morolimumab
2474:Cedelizumab
2459:Anifrolumab
2454:Alemtuzumab
2412:Basiliximab
2382:Tocilizumab
2368:Vedolizumab
2363:Natalizumab
2349:Metelimumab
2292:Gavilimomab
2250:Toralizumab
2245:Teneliximab
2231:Lumiliximab
2226:Gomiliximab
2212:Ublituximab
2192:Ocrelizumab
2145:Zanolimumab
2121:Visilizumab
2079:Secukinumab
2063:Ustekinumab
2034:Elsilimomab
2018:Faralimomab
1986:Mepolizumab
1970:Ustekinumab
1965:Tocilizumab
1940:Secukinumab
1890:Canakinumab
1880:Briakinumab
1875:Bimekizumab
1870:Basiliximab
1859:Interleukin
1849:Nerelimomab
1754:Zotarolimus
1695:(reception)
1666:Thalidomide
1624:Voclosporin
1609:Ciclosporin
1603:Calcineurin
1599:Cyclophilin
1546:Leflunomide
1542:inhibitors
1154:NCT00784628
1030:23 February
963:1 September
909:(1): 3–13.
581:(MKD), and
505:Canakinumab
480: g·mol
318:914613-48-2
303:Identifiers
213:Intravenous
169:Canakinumab
136:MedlinePlus
109:Other names
100:Trade names
23:Canakinumab
5260:Categories
5006:B (IFN-λ3)
5002:A (IFN-λ2)
4936:Guselkumab
4926:Brazikumab
4821:Fletikumab
4724:Remtolumab
4714:Ixekizumab
4709:Brodalumab
4592:Binetrakin
4530:Oprelvekin
4499:Ilodecakin
4478:Enokizumab
4391:Siltuximab
4381:Olokizumab
4315:Reslizumab
4249:Pitrakinra
4229:Binetrakin
4198:Milodistim
4193:Leridistim
4162:Inolimomab
4137:Teceleukin
4056:Isunakinra
3993:modulators
3862:Lokivetmab
3855:Veterinary
3841:Spesolimab
3826:Olokizumab
3811:Ixekizumab
3755:Guselkumab
3750:Fletikumab
3730:Brazikumab
3725:Bermekimab
3696:Sutimlimab
3670:Ibalizumab
3607:Teplizumab
3587:Siplizumab
3572:Ruplizumab
3552:Reslizumab
3542:Quilizumab
3497:Omalizumab
3447:Itolizumab
3437:Frexalimab
3412:Efalizumab
3407:Eculizumab
3402:Daclizumab
3367:Aselizumab
3362:Apolizumab
3331:Priliximab
3316:Infliximab
3258:Odulimomab
3248:Maslimomab
3243:Inolimomab
3223:Afelimomab
3160:Durvalumab
3155:Ipilimumab
3144:Varlilumab
3114:Relatlimab
3109:Placulumab
3053:Lenzilumab
3028:Emapalumab
3013:Cemiplimab
2998:Brodalumab
2993:Bleselumab
2963:Adalimumab
2868:Sutimlimab
2863:Spesolimab
2848:Siltuximab
2788:Olokizumab
2778:Ixekizumab
2773:Itacitinib
2763:Guselkumab
2758:Fingolimod
2753:Filgotinib
2703:Crovalimab
2693:Brodalumab
2683:Blisibimod
2648:Rilonacept
2631:Opinercept
2626:Etanercept
2612:Belatacept
2563:Polyclonal
2524:Siplizumab
2514:Reslizumab
2504:Ofatumumab
2494:Maslimomab
2479:Emapalumab
2422:Inolimomab
2417:Daclizumab
2396:Odulimomab
2311:Ruplizumab
2306:Frexalimab
2264:Aselizumab
2159:Efalizumab
2116:Teplizumab
2012:Interferon
2002:Omalizumab
1955:Spesolimab
1945:Siltuximab
1920:Rilonacept
1915:Olokizumab
1905:Ixekizumab
1900:Guselkumab
1895:Daclizumab
1885:Brodalumab
1844:Infliximab
1829:Afelimomab
1824:Adalimumab
1808:Eculizumab
1784:Monoclonal
1775:Antibodies
1749:Umirolimus
1729:Everolimus
1678:Apremilast
1638:Gusperimus
1619:Tacrolimus
1587:inhibitors
1579:Macrolides
1561:antifolate
1250:4 November
1178:(4): 285.
712:References
513:medication
469:Molar mass
374:37CQ2C7X93
349:ChemSpider
309:CAS Number
5211:Unsorted:
5072:Agonists:
5051:Agonists:
5030:Agonists:
4990:Agonists:
4969:Agonists:
4913:Agonists:
4881:Agonists:
4840:Agonists:
4798:Agonists:
4770:Tadekinig
4752:Agonists:
4671:Agonists:
4645:Agonists:
4589:Agonists:
4548:Agonists:
4522:Agonists:
4496:Agonists:
4465:Agonists:
4424:Agonists:
4406:Levilimab
4396:Sirukumab
4386:Sarilumab
4343:Agonists:
4282:Agonists:
4259:Dupilumab
4226:Agonists:
4203:Muplestim
4180:Agonists:
4104:Agonists:
4031:Pifonakin
4026:Mobenakin
4009:Agonists:
3942:Phase III
3930:Withdrawn
3907:Sulesomab
3784:Humanized
3765:Sirukumab
3597:Talizumab
3422:Erlizumab
3351:Humanized
3321:Keliximab
3306:Galiximab
3165:Nivolumab
3129:Tabalumab
3119:Sarilumab
3093:Oleclumab
3088:Namilumab
3068:Lirilumab
3043:Ianalumab
3038:Golimumab
3023:Eldelumab
3018:Dupilumab
2988:Belimumab
2958:Abrilumab
2858:Sirukumab
2853:Siponimod
2838:Sarilumab
2813:Ponesimod
2783:Netakimab
2768:Iptacopan
2748:Etrasimod
2708:Danicopan
2643:Alefacept
2607:Abatacept
2529:Talizumab
2469:Begelomab
2325:Belimumab
2278:Galiximab
2207:Rituximab
2173:Erlizumab
2140:Keliximab
1950:Sirukumab
1930:Sarilumab
1910:Netakimab
1839:Golimumab
1739:Sirolimus
607:(TRAPS),
573:(TRAPS),
206:Routes of
180:Pregnancy
128:Monograph
122:Drugs.com
5250:Medicine
5165:IL-22Rα1
5131:instead.
4448:instead.
4376:mAb 1339
4361:ARGX-109
4325:TPI ASM8
4295:YM-90709
4046:Anakinra
4041:AF-12198
3283:Chimeric
3175:Urelumab
3098:Oxelumab
3008:Carlumab
2978:Avelumab
2927:for the
2793:Ozanimod
2668:Avacopan
2661:Unsorted
2447:Unsorted
2357:Integrin
2090:Cellular
1865:Anakinra
1711:Anakinra
1633:Abetimus
1485: /
1423:29666299
1372:29922680
1301:25177840
1292:10891421
1192:29625221
1139:37533141
1130:10486173
1057:14 April
1006:19494217
958:Medscape
933:20065636
786:DailyMed
761:26284424
652:Novartis
603:(CAPS),
495:(verify)
329:DrugBank
224:ATC code
195: B3
182:category
164:DailyMed
5183:IL-10Rβ
5179:IL-20Rα
5169:IL-20Rβ
5103:IL-36RA
4648:ALT-803
3877:lesions
3652:TGN1412
3537:PRO 140
2589:-cept (
1414:6067938
1363:5996084
1022:. U.S.
924:2828573
872:16 June
828:16 June
792:16 June
752:4966334
660:phase I
646:History
619:(FMF),
615:(MKD),
611:(HIDS)/
585:(FMF).
577:(HIDS)/
511:, is a
430:Formula
338:DB06168
240:)
234: (
232:L04AC08
166::
142:a622024
5236:Portal
5139:Others
5112:Others
5064:IL1RL2
5043:IL1RL1
4780:IL18BP
4051:IL-1RA
3925:WHO-EM
3667:Other:
2601:CTLA-4
2591:Fusion
2092:target
2073:IL-17A
2050:, and
1583:other
1421:
1411:
1370:
1360:
1346:: 62.
1299:
1289:
1220:6 June
1190:
1137:
1127:
1004:
931:
921:
759:
749:
673:, and
623:, and
562:, and
509:Ilaris
405:ChEMBL
394:D09315
282:℞-only
280:
267:
162:
104:Ilaris
83:Target
71:Source
42:entry
5022:IL-31
4982:IL-28
4961:IL-27
4905:IL-23
4873:IL-22
4832:IL-21
4790:IL-20
4744:IL-18
4663:IL-17
4637:IL-15
4581:IL-13
4540:IL-12
4514:IL-11
4488:IL-10
3885:Mouse
3718:Human
3216:Mouse
3182:Other
2945:Human
2390:LFA-1
2300:CD154
2153:CD11a
2052:IL-23
2048:IL-13
2044:IL-12
1648:IMiDs
1240:NeuRA
1188:S2CID
866:(FDA)
862:U.S.
822:(EMA)
88:IL-1β
76:Human
5129:here
5127:See
4457:IL-9
4446:here
4437:IL-8
4416:IL-7
4335:IL-6
4274:IL-5
4218:IL-4
4172:IL-3
4096:IL-2
4001:IL-1
2320:BLyS
2272:CD80
2239:CD40
2220:CD23
2181:CD20
2167:CD18
2028:IL-6
1721:mTOR
1595:FKBP
1585:IL-2
1419:PMID
1368:PMID
1297:PMID
1275:2014
1252:2016
1222:2017
1135:PMID
1059:2010
1032:2023
1002:PMID
965:2023
929:PMID
903:mAbs
874:2020
830:2020
794:2020
757:PMID
731:mAbs
671:gout
456:2010
450:1722
444:9958
438:6452
385:KEGG
365:UNII
356:none
118:AHFS
61:Type
45:5bvp
5155:CD4
5120:JAK
2333:CAT
2129:CD4
2100:CD3
1818:TNF
1491:L04
1409:PMC
1399:doi
1358:PMC
1348:doi
1287:PMC
1279:doi
1180:doi
1125:PMC
1117:doi
992:doi
988:360
919:PMC
911:doi
747:PMC
739:doi
478:.20
476:157
474:145
237:WHO
40:PDB
5262::
5085:,
5081:,
5004:,
4696:,
4692:,
4688:,
4684:,
4680:,
4018:,
3938::
3661::
3205::
3184::
3153::
2956::
2046:,
1443:.
1417:.
1407:.
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1393:.
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1338:.
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1295:.
1285:.
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1000:.
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956:.
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901:.
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733:.
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627:.
599:,
592:.
566:.
558:,
462:42
288:EU
276:US
269:S4
263:AU
215:,
191:AU
159:US
5238::
5200:)
5181:/
5167:/
5157:)
5089:)
5087:γ
5083:β
5079:α
5077:(
5008:)
5000:(
4700:)
4698:F
4690:D
4686:C
4682:B
4678:A
4676:(
4022:)
4020:β
4016:α
4014:(
3982:e
3975:t
3968:v
3493:)
3489:(
3100:§
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1119::
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1034:.
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967:.
935:.
913::
907:2
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876:.
832:.
796:.
763:.
741::
735:7
690:P
459:S
453:O
447:N
441:H
435:C
290::
278::
265::
193::
120:/
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