336:
313:
210:
235:
601:
594:
587:
342:
241:
31:
2775:
1344:), caspase 2 has been shown to form the so-called PIDDosome, which may serve as an activation platform for the protease, although it may also be activated in the absence of PIDD. Overall, caspase 2 appears to be a very versatile caspase with multiple functions beyond cell death induction.
57:
1488:
Kumar S, White DL, Takai S, Turczynowicz S, Juttner CA, Hughes TP (June 1995). "Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms".
1258:
residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli.
1532:
349:
248:
1998:"Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases"
1901:
Droin N, Beauchemin M, Solary E, Bertrand R (December 2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade".
2127:
2092:
914:
1862:"Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3"
171:
895:
1470:
2795:
1452:
1360:
1616:
Tinel A, Tschopp J (May 2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress".
1333:
1134:
335:
2494:
1141:
312:
2120:
1558:
1536:
1439:
1418:
2650:
1435:
234:
209:
54:
1414:
151:
2278:
2273:
2113:
1353:
348:
247:
2765:
2635:
341:
240:
2751:
2738:
2725:
2712:
2699:
2686:
2673:
2147:
2645:
1669:
Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A (April 2009).
2599:
2542:
2144:
959:
159:
2547:
2338:
940:
2568:
2487:
1929:
2640:
2009:
1944:
1627:
223:
138:
2604:
2431:
1670:
1385:
1328:
using its CARD domain, including RIP-associated Ich-1/Ced-3-homologue protein with a death domain (
2800:
2537:
1978:
1651:
1514:
183:
1117:
1096:
1092:
1088:
1062:
1041:
1037:
1033:
1029:
2805:
2140:
2069:
2037:
1970:
1910:
1883:
1842:
1798:
1749:
1720:"Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase"
1700:
1643:
1618:
1595:
1506:
1266:
600:
131:
47:
740:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2583:
2578:
2552:
2480:
2451:
2343:
2333:
2328:
2323:
2318:
2105:
2027:
2017:
1960:
1952:
1873:
1832:
1788:
1780:
1739:
1731:
1690:
1682:
1635:
1585:
1498:
1337:
428:
359:
303:
258:
2298:
2063:
1329:
1282:
593:
179:
2630:
2614:
2527:
1317:
that is similar to that of caspase 9 and contains a protein interaction domain known as a
586:
403:
1254:. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved
2013:
1948:
1631:
2779:
2668:
2609:
1793:
1768:
1744:
1719:
1695:
30:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
723:
718:
713:
708:
703:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
2789:
2573:
2532:
2096:
2078:
2032:
1997:
1996:
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES (December 1996).
1278:
1255:
1231:
629:
1518:
2522:
2390:
2386:
1982:
1655:
1222:
for which complete genome data are available. Unique orthologs are also present in
421:
200:
1821:"Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria"
163:
187:
2746:
2681:
2517:
2461:
2456:
2426:
2410:
2405:
2400:
2395:
2381:
2376:
2371:
2366:
2361:
1819:
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002).
1475:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1457:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1318:
1262:
2774:
1590:
1573:
504:
2441:
2255:
2224:
2219:
2214:
2209:
1314:
1274:
320:
217:
167:
2022:
688:
cysteine-type endopeptidase activity involved in execution phase of apoptosis
2720:
2694:
2446:
2353:
2308:
2303:
2293:
2283:
2250:
2204:
2199:
2194:
2189:
2184:
2179:
2174:
2164:
1639:
1372:
1325:
1306:
1302:
1298:
1294:
1251:
1215:
859:
564:
442:
387:
374:
286:
273:
175:
1914:
1887:
1878:
1861:
1846:
1837:
1820:
1802:
1753:
1704:
1647:
1599:
2041:
1974:
1686:
1510:
1181:
1176:
2436:
2136:
1965:
1784:
1735:
1336:(ARC), and death effector filament-forming Ced-4-like apoptosis protein (
1165:
1004:
985:
2265:
2156:
2083:
2073:
1502:
1390:
1310:
1290:
1286:
1270:
1247:
1235:
971:
926:
1767:
Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A (February 2009).
1340:). Together with RAIDD and p53-induced protein with a death domain ()(
108:
104:
100:
96:
92:
88:
84:
80:
76:
2733:
2503:
2313:
2245:
2240:
2059:
1956:
1227:
1219:
1201:
1149:
881:
2707:
2288:
1366:
678:
cysteine-type endopeptidase activity involved in apoptotic process
1324:
It has been shown to associate with several proteins involved in
1285:
subfamily. It is one of the most conserved caspases in different
844:
840:
1341:
1223:
1208:
155:
2476:
2109:
785:
intrinsic apoptotic signaling pathway in response to DNA damage
1860:
Paroni G, Henderson C, Schneider C, Brancolini C (June 2001).
609:
2068:
Overview of all the structural information available in the
1671:"Caspase-2 activation in the absence of PIDDosome formation"
2472:
1289:
of animal. Caspase 2 has a similar amino acid sequence to
790:
extrinsic apoptotic signaling pathway in absence of ligand
411:
1718:
Krumschnabel G, Manzl C, Villunger A (September 2009).
1281:
residue. Within this family, caspase 2 is part of the
2763:
2062:
online database for peptidases and their inhibitors:
1533:"OrthoMaM phylogenetic marker: CASP2 coding sequence"
576:
1321:. Pro-caspase-2 contains two subunits, p19 and p12.
1250:
plays a central role in the execution-phase of cell
2659:
2623:
2592:
2561:
2510:
2419:
2352:
2264:
2233:
2155:
1334:
apoptosis repressor with caspase recruitment domain
1110:
1081:
1055:
1022:
1431:
1429:
1427:
1410:
1408:
1406:
1265:cleaves other proteins. It belongs to a family of
760:positive regulation of apoptotic signaling pathway
358:
257:
142:, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase 2
1814:
1812:
775:positive regulation of neuron apoptotic process
1611:
1609:
1574:"Caspase-2 function in response to DNA damage"
1436:GRCm38: Ensembl release 89: ENSMUSG00000029863
2488:
2121:
8:
1769:"The enigma of caspase-2: the laymen's view"
1415:GRCh38: Ensembl release 89: ENSG00000106144
2495:
2481:
2473:
2128:
2114:
2106:
2093:United States National Library of Medicine
855:
625:
399:
298:
195:
65:
2031:
2021:
1964:
1930:"RAIDD is a new 'death' adaptor molecule"
1877:
1836:
1792:
1743:
1694:
1589:
531:fetal liver hematopoietic progenitor cell
2091:This article incorporates text from the
830:negative regulation of apoptotic process
795:positive regulation of apoptotic process
770:cellular response to mechanical stimulus
2770:
1402:
800:ectopic germ cell programmed cell death
20:
363:
324:
319:
262:
221:
216:
7:
1361:BH3 interacting domain death agonist
683:cysteine-type endopeptidase activity
1218:have been identified in nearly all
1204:that, in humans, is encoded by the
1572:Zhivotovsky B, Orrenius S (2005).
1107:
1078:
1052:
1019:
995:
976:
950:
931:
905:
886:
581:
499:
437:
416:
14:
1928:Duan H, Dixit VM (January 1997).
2773:
1273:that cleave proteins only at an
643:cysteine-type peptidase activity
599:
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
29:
820:regulation of apoptotic process
648:protein domain specific binding
610:More reference expression data
565:More reference expression data
1:
1578:Biochem. Biophys. Res. Commun
332:
231:
2002:Proc. Natl. Acad. Sci. U.S.A
1352:Caspase 2 has been shown to
745:execution phase of apoptosis
2796:Genes on human chromosome 7
805:apoptotic signaling pathway
2822:
1591:10.1016/j.bbrc.2005.03.191
2651:Michaelis–Menten kinetics
2082:(Human Caspase-2) at the
1471:"Mouse PubMed Reference:"
1453:"Human PubMed Reference:"
1246:Sequential activation of
1180:
1175:
1171:
1164:
1148:
1135:Chr 7: 143.29 – 143.31 Mb
1129:
1114:
1085:
1074:
1059:
1026:
1015:
1002:
998:
983:
979:
970:
957:
953:
938:
934:
925:
912:
908:
893:
889:
880:
865:
858:
854:
838:
810:neural retina development
673:identical protein binding
628:
624:
607:
584:
575:
562:
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
73:
68:
51:
46:
41:
37:
28:
23:
2543:Diffusion-limited enzyme
2023:10.1073/pnas.93.25.14486
1313:, which contains a long
457:tendon of biceps brachii
1640:10.1126/science.1095432
1142:Chr 6: 42.24 – 42.26 Mb
485:mucosa of sigmoid colon
1879:10.1074/jbc.M011565200
1838:10.1074/jbc.M108029200
1309:. It is produced as a
365:6 B2.1|6 20.54 cM
16:Enzyme found in humans
2636:Eadie–Hofstee diagram
2569:Allosteric regulation
1687:10.1083/jcb.200811105
539:mandibular prominence
2646:Lineweaver–Burk plot
1785:10.1038/cdd.2008.170
1736:10.1038/onc.2009.173
1559:"Entrez Gene: CASP2"
1539:on 24 September 2015
535:maxillary prominence
326:Chromosome 6 (mouse)
224:Chromosome 7 (human)
69:List of PDB id codes
42:Available structures
2432:Cancer procoagulant
2014:1996PNAS...9314486S
1949:1997Natur.385...86D
1632:2004Sci...304..843T
1386:The Proteolysis Map
527:endocardial cushion
477:ganglionic eminence
2605:Enzyme superfamily
2538:Enzyme promiscuity
2141:cysteine proteases
2095:, which is in the
1503:10.1007/bf00209480
1291:initiator caspases
1267:cysteine proteases
960:ENSMUSG00000029863
750:protein processing
733:Biological process
697:Cellular component
668:hydrolase activity
653:peptidase activity
636:Molecular function
453:buccal mucosa cell
2761:
2760:
2470:
2469:
1773:Cell Death Differ
1191:
1190:
1187:
1186:
1160:
1159:
1125:
1124:
1104:
1103:
1070:
1069:
1049:
1048:
1011:
1010:
992:
991:
966:
965:
947:
946:
921:
920:
902:
901:
850:
849:
815:apoptotic process
780:brain development
620:
619:
616:
615:
571:
570:
558:
557:
496:
495:
394:
393:
293:
292:
188:CASP2 - orthologs
120:
119:
116:
115:
52:Ortholog search:
2813:
2778:
2777:
2769:
2641:Hanes–Woolf plot
2584:Enzyme activator
2579:Enzyme inhibitor
2553:Enzyme catalysis
2497:
2490:
2483:
2474:
2452:3C-like protease
2130:
2123:
2116:
2107:
2046:
2045:
2035:
2025:
2008:(25): 14486–91.
1993:
1987:
1986:
1968:
1957:10.1038/385086a0
1934:
1925:
1919:
1918:
1898:
1892:
1891:
1881:
1872:(24): 21907–15.
1857:
1851:
1850:
1840:
1816:
1807:
1806:
1796:
1764:
1758:
1757:
1747:
1715:
1709:
1708:
1698:
1666:
1660:
1659:
1613:
1604:
1603:
1593:
1569:
1563:
1562:
1555:
1549:
1548:
1546:
1544:
1535:. Archived from
1529:
1523:
1522:
1485:
1479:
1478:
1467:
1461:
1460:
1449:
1443:
1433:
1422:
1412:
1173:
1172:
1144:
1137:
1120:
1108:
1099:
1079:
1075:RefSeq (protein)
1065:
1053:
1044:
1020:
996:
977:
951:
932:
906:
887:
856:
626:
612:
603:
596:
589:
582:
567:
507:
505:Top expressed in
500:
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
141:
134:
111:
66:
60:
39:
38:
33:
21:
2821:
2820:
2816:
2815:
2814:
2812:
2811:
2810:
2786:
2785:
2784:
2772:
2764:
2762:
2757:
2669:Oxidoreductases
2655:
2631:Enzyme kinetics
2619:
2615:List of enzymes
2588:
2557:
2528:Catalytic triad
2506:
2501:
2471:
2466:
2415:
2348:
2260:
2229:
2151:
2134:
2103:
2055:
2050:
2049:
1995:
1994:
1990:
1932:
1927:
1926:
1922:
1909:(24): 7039–47.
1900:
1899:
1895:
1859:
1858:
1854:
1831:(16): 13430–7.
1818:
1817:
1810:
1766:
1765:
1761:
1717:
1716:
1712:
1668:
1667:
1663:
1626:(5672): 843–6.
1615:
1614:
1607:
1571:
1570:
1566:
1557:
1556:
1552:
1542:
1540:
1531:
1530:
1526:
1487:
1486:
1482:
1469:
1468:
1464:
1451:
1450:
1446:
1434:
1425:
1413:
1404:
1399:
1382:
1350:
1263:proteolytically
1244:
1182:View/Edit Mouse
1177:View/Edit Human
1140:
1133:
1130:Location (UCSC)
1116:
1095:
1091:
1087:
1061:
1040:
1036:
1032:
1028:
941:ENSG00000106144
834:
728:
692:
658:protein binding
608:
598:
597:
591:
590:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
479:
475:
471:
467:
463:
461:trabecular bone
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
75:
53:
17:
12:
11:
5:
2819:
2817:
2809:
2808:
2803:
2798:
2788:
2787:
2783:
2782:
2759:
2758:
2756:
2755:
2742:
2729:
2716:
2703:
2690:
2677:
2663:
2661:
2657:
2656:
2654:
2653:
2648:
2643:
2638:
2633:
2627:
2625:
2621:
2620:
2618:
2617:
2612:
2607:
2602:
2596:
2594:
2593:Classification
2590:
2589:
2587:
2586:
2581:
2576:
2571:
2565:
2563:
2559:
2558:
2556:
2555:
2550:
2545:
2540:
2535:
2530:
2525:
2520:
2514:
2512:
2508:
2507:
2502:
2500:
2499:
2492:
2485:
2477:
2468:
2467:
2465:
2464:
2459:
2454:
2449:
2444:
2439:
2434:
2429:
2423:
2421:
2417:
2416:
2414:
2413:
2408:
2403:
2398:
2393:
2384:
2379:
2374:
2369:
2364:
2358:
2356:
2350:
2349:
2347:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2276:
2270:
2268:
2262:
2261:
2259:
2258:
2253:
2248:
2243:
2237:
2235:
2231:
2230:
2228:
2227:
2222:
2217:
2212:
2207:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2161:
2159:
2153:
2152:
2135:
2133:
2132:
2125:
2118:
2110:
2088:
2087:
2066:
2054:
2053:External links
2051:
2048:
2047:
1988:
1943:(6611): 86–9.
1920:
1893:
1852:
1808:
1779:(2): 195–207.
1759:
1730:(35): 3093–6.
1710:
1681:(2): 291–303.
1661:
1605:
1564:
1550:
1524:
1480:
1462:
1444:
1423:
1401:
1400:
1398:
1395:
1394:
1393:
1388:
1381:
1378:
1377:
1376:
1370:
1364:
1349:
1346:
1243:
1240:
1232:lissamphibians
1196:also known as
1189:
1188:
1185:
1184:
1179:
1169:
1168:
1162:
1161:
1158:
1157:
1155:
1153:
1146:
1145:
1138:
1131:
1127:
1126:
1123:
1122:
1112:
1111:
1105:
1102:
1101:
1083:
1082:
1076:
1072:
1071:
1068:
1067:
1057:
1056:
1050:
1047:
1046:
1024:
1023:
1017:
1013:
1012:
1009:
1008:
1000:
999:
993:
990:
989:
981:
980:
974:
968:
967:
964:
963:
955:
954:
948:
945:
944:
936:
935:
929:
923:
922:
919:
918:
910:
909:
903:
900:
899:
891:
890:
884:
878:
877:
872:
867:
863:
862:
852:
851:
848:
847:
836:
835:
833:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
736:
734:
730:
729:
727:
726:
721:
716:
711:
706:
700:
698:
694:
693:
691:
690:
685:
680:
675:
670:
665:
663:enzyme binding
660:
655:
650:
645:
639:
637:
633:
632:
622:
621:
618:
617:
614:
613:
605:
604:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
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491:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
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245:
238:
232:
228:
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220:
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205:
204:
192:
191:
148:
144:
143:
135:
127:
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118:
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114:
113:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2818:
2807:
2804:
2802:
2799:
2797:
2794:
2793:
2791:
2781:
2776:
2771:
2767:
2753:
2749:
2748:
2743:
2740:
2736:
2735:
2730:
2727:
2723:
2722:
2717:
2714:
2710:
2709:
2704:
2701:
2697:
2696:
2691:
2688:
2684:
2683:
2678:
2675:
2671:
2670:
2665:
2664:
2662:
2658:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2628:
2626:
2622:
2616:
2613:
2611:
2610:Enzyme family
2608:
2606:
2603:
2601:
2598:
2597:
2595:
2591:
2585:
2582:
2580:
2577:
2575:
2574:Cooperativity
2572:
2570:
2567:
2566:
2564:
2560:
2554:
2551:
2549:
2546:
2544:
2541:
2539:
2536:
2534:
2533:Oxyanion hole
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2515:
2513:
2509:
2505:
2498:
2493:
2491:
2486:
2484:
2479:
2478:
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2460:
2458:
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2433:
2430:
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2422:
2418:
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2399:
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2368:
2365:
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2357:
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2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2271:
2269:
2267:
2263:
2257:
2254:
2252:
2249:
2247:
2244:
2242:
2239:
2238:
2236:
2234:Fruit-derived
2232:
2226:
2223:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2162:
2160:
2158:
2154:
2149:
2146:
2142:
2138:
2131:
2126:
2124:
2119:
2117:
2112:
2111:
2108:
2104:
2101:
2100:
2098:
2097:public domain
2094:
2085:
2081:
2080:
2075:
2071:
2067:
2065:
2061:
2057:
2056:
2052:
2043:
2039:
2034:
2029:
2024:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1989:
1984:
1980:
1976:
1972:
1967:
1966:2027.42/62739
1962:
1958:
1954:
1950:
1946:
1942:
1938:
1931:
1924:
1921:
1916:
1912:
1908:
1904:
1897:
1894:
1889:
1885:
1880:
1875:
1871:
1867:
1866:J. Biol. Chem
1863:
1856:
1853:
1848:
1844:
1839:
1834:
1830:
1826:
1825:J. Biol. Chem
1822:
1815:
1813:
1809:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1763:
1760:
1755:
1751:
1746:
1741:
1737:
1733:
1729:
1725:
1721:
1714:
1711:
1706:
1702:
1697:
1692:
1688:
1684:
1680:
1676:
1672:
1665:
1662:
1657:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1620:
1612:
1610:
1606:
1601:
1597:
1592:
1587:
1584:(3): 859–67.
1583:
1579:
1575:
1568:
1565:
1560:
1554:
1551:
1538:
1534:
1528:
1525:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1484:
1481:
1476:
1472:
1466:
1463:
1458:
1454:
1448:
1445:
1441:
1437:
1432:
1430:
1428:
1424:
1420:
1416:
1411:
1409:
1407:
1403:
1396:
1392:
1389:
1387:
1384:
1383:
1379:
1374:
1371:
1368:
1365:
1362:
1359:
1358:
1357:
1355:
1347:
1345:
1343:
1339:
1335:
1331:
1327:
1322:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1284:
1280:
1279:aspartic acid
1277:following an
1276:
1272:
1268:
1264:
1259:
1257:
1253:
1249:
1241:
1239:
1237:
1233:
1229:
1225:
1221:
1217:
1214:
1210:
1207:
1203:
1199:
1195:
1183:
1178:
1174:
1170:
1167:
1163:
1156:
1154:
1151:
1147:
1143:
1139:
1136:
1132:
1128:
1121:
1119:
1113:
1109:
1106:
1100:
1098:
1094:
1090:
1084:
1080:
1077:
1073:
1066:
1064:
1058:
1054:
1051:
1045:
1043:
1039:
1035:
1031:
1025:
1021:
1018:
1016:RefSeq (mRNA)
1014:
1007:
1006:
1001:
997:
994:
988:
987:
982:
978:
975:
973:
969:
962:
961:
956:
952:
949:
943:
942:
937:
933:
930:
928:
924:
917:
916:
911:
907:
904:
898:
897:
892:
888:
885:
883:
879:
876:
873:
871:
868:
864:
861:
857:
853:
846:
842:
837:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
737:
735:
732:
731:
725:
722:
720:
719:mitochondrion
717:
715:
712:
710:
707:
705:
702:
701:
699:
696:
695:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
631:
630:Gene ontology
627:
623:
611:
606:
602:
595:
588:
583:
580:
578:
574:
566:
561:
551:Gonadal ridge
550:
547:hair follicle
546:
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
469:skin of thigh
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2747:Translocases
2744:
2731:
2718:
2705:
2692:
2682:Transferases
2679:
2666:
2523:Binding site
2169:
2102:
2090:
2089:
2077:
2005:
2001:
1991:
1940:
1936:
1923:
1906:
1902:
1896:
1869:
1865:
1855:
1828:
1824:
1776:
1772:
1762:
1727:
1723:
1713:
1678:
1675:J. Cell Biol
1674:
1664:
1623:
1617:
1581:
1577:
1567:
1553:
1541:. Retrieved
1537:the original
1527:
1497:(6): 641–4.
1494:
1490:
1483:
1474:
1465:
1456:
1447:
1351:
1348:Interactions
1323:
1293:, including
1260:
1245:
1212:
1205:
1197:
1193:
1192:
1115:
1086:
1060:
1027:
1003:
984:
958:
939:
913:
894:
874:
869:
755:human ageing
523:otic vesicle
519:otic placode
427:
420:
285:143,307,696
272:143,288,215
147:External IDs
74:
18:
2518:Active site
2462:Gingipain K
2457:Gingipain R
2427:Clostripain
1543:20 December
1319:CARD domain
825:proteolysis
465:skin of hip
386:42,259,442
373:42,241,919
125:Identifiers
2790:Categories
2721:Isomerases
2695:Hydrolases
2562:Regulation
2442:Autophagin
2256:Actinidain
2225:Caspase 14
2220:Caspase 13
2215:Caspase 12
2210:Caspase 10
1903:Cancer Res
1491:Hum. Genet
1442:, May 2017
1421:, May 2017
1397:References
1315:pro-domain
1275:amino acid
1261:Caspase 2
765:luteolysis
431:(ortholog)
168:HomoloGene
2801:EC 3.4.22
2600:EC number
2447:Cruzipain
2354:Cathepsin
2251:Bromelain
2205:Caspase 9
2200:Caspase 8
2195:Caspase 7
2190:Caspase 6
2185:Caspase 5
2180:Caspase 4
2175:Caspase 3
2170:Caspase 2
2165:Caspase 1
2137:Proteases
1373:Caspase 8
1326:apoptosis
1307:caspase 9
1303:caspase 5
1299:caspase 4
1295:caspase 1
1252:apoptosis
1216:orthologs
1194:Caspase 2
1118:NP_031636
1097:NP_116765
1093:NP_116764
1089:NP_001215
1063:NM_007610
1042:NM_032984
1038:NM_032982
1034:NM_001224
1030:NM_032983
860:Orthologs
704:cytoplasm
176:GeneCards
2806:Caspases
2624:Kinetics
2548:Cofactor
2511:Activity
2437:Separase
1915:11156409
1888:11399776
1847:11832478
1803:19023332
1754:19581929
1724:Oncogene
1705:19364921
1648:15073321
1600:15865942
1519:22813779
1438:–
1417:–
1380:See also
1354:interact
1271:caspases
1256:aspartic
1248:caspases
1242:Function
1236:teleosts
1166:Wikidata
839:Sources:
714:membrane
489:testicle
2780:Biology
2734:Ligases
2504:Enzymes
2266:Calpain
2157:Caspase
2084:PDBe-KB
2074:UniProt
2064:C14.006
2042:8962078
2010:Bibcode
1983:4317538
1975:8985253
1945:Bibcode
1794:3272397
1745:3272399
1696:2700374
1656:6583298
1628:Bibcode
1619:Science
1511:7789948
1440:Ensembl
1419:Ensembl
1391:Caspase
1311:zymogen
1287:species
1269:called
1228:lizards
1220:mammals
972:UniProt
927:Ensembl
866:Species
845:QuickGO
724:nucleus
709:cytosol
515:saccule
406:pattern
132:Aliases
2766:Portal
2708:Lyases
2344:CAPNS2
2339:CAPNS1
2334:CAPN14
2329:CAPN13
2324:CAPN12
2319:CAPN11
2314:CAPN10
2246:Ficain
2241:Papain
2148:3.4.22
2079:P42575
2060:MEROPS
2040:
2030:
1981:
1973:
1937:Nature
1913:
1886:
1845:
1801:
1791:
1752:
1742:
1703:
1693:
1654:
1646:
1598:
1517:
1509:
1356:with:
1338:DEFCAP
1305:, and
1234:, and
1202:enzyme
1200:is an
1152:search
1150:PubMed
1005:P29594
986:P42575
882:Entrez
577:BioGPS
543:thymus
473:tonsil
156:600639
2660:Types
2420:Other
2309:CAPN9
2304:CAPN8
2299:CAPN7
2294:CAPN6
2289:CAPN5
2284:CAPN3
2279:CAPN2
2274:CAPN1
2033:26159
1979:S2CID
1933:(PDF)
1652:S2CID
1515:S2CID
1369:, and
1367:CRADD
1330:RAIDD
1283:Ich-1
1224:birds
1213:CASP2
1206:CASP2
1198:CASP2
915:12366
875:Mouse
870:Human
841:Amigo
481:blood
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
180:CASP2
164:97295
139:CASP2
24:CASP2
2752:list
2745:EC7
2739:list
2732:EC6
2726:list
2719:EC5
2713:list
2706:EC4
2700:list
2693:EC3
2687:list
2680:EC2
2674:list
2667:EC1
2072:for
2058:The
2038:PMID
1971:PMID
1911:PMID
1884:PMID
1843:PMID
1799:PMID
1750:PMID
1701:PMID
1644:PMID
1596:PMID
1545:2009
1507:PMID
1342:LRDD
1209:gene
412:Bgee
360:Band
321:Chr.
264:7q34
259:Band
218:Chr.
172:7254
152:OMIM
109:3RJM
105:3R7S
101:3R7N
97:3R7B
93:3R6L
89:3R6G
85:3R5J
81:2P2C
77:1PYO
58:RCSB
55:PDBe
2070:PDB
2028:PMC
2018:doi
1961:hdl
1953:doi
1941:385
1874:doi
1870:276
1833:doi
1829:277
1789:PMC
1781:doi
1740:PMC
1732:doi
1691:PMC
1683:doi
1679:185
1636:doi
1624:304
1586:doi
1582:331
1499:doi
1332:),
896:835
382:End
281:End
184:OMA
160:MGI
48:PDB
2792::
2391:L2
2387:L1
2145:EC
2139::
2076::
2036:.
2026:.
2016:.
2006:93
2004:.
2000:.
1977:.
1969:.
1959:.
1951:.
1939:.
1935:.
1907:60
1905:.
1882:.
1868:.
1864:.
1841:.
1827:.
1823:.
1811:^
1797:.
1787:.
1777:16
1775:.
1771:.
1748:.
1738:.
1728:28
1726:.
1722:.
1699:.
1689:.
1677:.
1673:.
1650:.
1642:.
1634:.
1622:.
1608:^
1594:.
1580:.
1576:.
1513:.
1505:.
1495:95
1493:.
1473:.
1455:.
1426:^
1405:^
1301:,
1297:,
1238:.
1230:,
1226:,
1211:.
843:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
2768::
2754:)
2750:(
2741:)
2737:(
2728:)
2724:(
2715:)
2711:(
2702:)
2698:(
2689:)
2685:(
2676:)
2672:(
2496:e
2489:t
2482:v
2411:Z
2406:W
2401:S
2396:O
2389:/
2382:K
2377:H
2372:F
2367:C
2362:B
2150:)
2143:(
2129:e
2122:t
2115:v
2099:.
2086:.
2044:.
2020::
2012::
1985:.
1963::
1955::
1947::
1917:.
1890:.
1876::
1849:.
1835::
1805:.
1783::
1756:.
1734::
1707:.
1685::
1658:.
1638::
1630::
1602:.
1588::
1561:.
1547:.
1521:.
1501::
1477:.
1459:.
1375:.
1363:,
306:)
203:)
186::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
