305:
282:
29:
557:
A clinical trial for small hepatocellular carcinoma was stopped prematurely because 56% of the treated patients had unacceptable side effects. Moreover, the treatment had no survival advantage for stage 1 and 2 cancer patients. This may be a reason why carmofur was never pursued for FDA-approval in
44:
1-hexylcarbamoyl-5-fluorouracil, HCFU, N-hexylcarbamoyl-5-fluorouracil, Yamaful, NCGC00095165-01, Hexylcarbamoyl fluorouracil, 61422-45-5, UNII-HA82M3RAB2, CCRIS 2759, C11H16FN3O3, Uracil, 5-fluoro-1-hexylcarbamoyl-, BRN 0888898, HA82M3RAB2, 1(2H)-Pyrimidinecarboxamide,
566:
Ozaki et al. have reported a synthesis by treating 5-FU with phosgene and hexylamine. Xiong et al. reported an alternative approach for the synthesis of carmofur . Chemical preparations and structures can be found here.
928:
Yamada T, Okamura S, Okazaki T, Ushiroyama T, Yanagawa Y, Ueki M, et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the
Japanese literature".
507:
influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor cells to the effects of antineoplastic agents and radiation. Carmofur, much more effective than
82:
435:
1126:
1082:
Ozaki S, Nagase T, Ahmad S, Tamai H, Hoshi A, Iigo M (1987). "Synthesis and antitumor activity of 1- or 3-(alpha-hetero substituted)alkyl-5-fluorouracil derivatives".
50:
2866:
1826:
391:
2802:
1119:
2409:
1561:
1517:
1395:
377:
1320:
456:
411:
1112:
2856:
2042:
1836:
484:
115:
990:
Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients".
848:"An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer"
2455:
1457:
1347:
523:
Product marketing for carmofur started in 1981. Carmofur has also been used as adjuvant chemotherapy for curatively resected
2377:
2360:
2235:
1999:
1377:
2109:
1705:
221:
2819:
2311:
1104:
261:
803:
Sakamoto J, Oba K, Matsui T, Kobayashi M (October 2006). "Efficacy of oral anticancer agents for colorectal cancer".
2861:
1491:
590:"Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs"
2846:
2677:
2557:
2547:
551:
2851:
2729:
2662:
2632:
2250:
1500:
539:
2807:
2714:
2532:
2247:
1733:
1581:
1508:
68:
300:
2612:
2602:
2335:
2177:
483:
Carmofur prodrug is ingested and taken up in the intestine, overcoming the problem of 5-FU degradation by
419:
InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
250:
1884:
1701:
1671:
1531:
1035:"Adjuvant oral chemotherapy to prevent recurrence after curative resection for hepatocellular carcinoma"
531:
have confirmed that the drug is effective on patients with this cancer type, extending their survival.
2282:
2159:
1680:
1596:
756:
drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency"
657:
646:"Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity"
2567:
2467:
2446:
2167:
1989:
1821:
1552:
1448:
750:
Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, et al. (December 2017).
464:
277:
136:
1625:
1064:
1015:
889:"Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur"
828:
644:
Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, et al. (Jan 2013).
2774:
1655:
1635:
1620:
701:
Doan NB, Nguyen HS, Montoure A, Al-Gizawiy MM, Mueller WM, Kurpad S, et al. (April 2017).
2749:
2323:
1157:
1091:
1056:
1007:
972:
945:
910:
869:
820:
785:
732:
683:
619:
554:, characterized by progressive damage to white matter in the brain with stroke-like symptoms.
495:
The mechanism of action of carmofur prodrug is traditionally thought to be the generation of
2754:
2511:
2226:
1860:
1845:
1566:
1046:
999:
937:
900:
859:
846:
Sakamoto J, Hamada C, Rahman M, Kodaira S, Ito K, Nakazato H, et al. (September 2005).
812:
775:
767:
722:
714:
673:
665:
609:
601:
535:
317:
230:
145:
2193:
2155:
1946:
1368:
1283:
500:
210:
304:
281:
661:
2813:
2347:
1938:
1432:
1296:
1183:
1153:
1140:
941:
780:
751:
727:
702:
678:
645:
614:
589:
468:
511:, has been reported as the small-molecule drug capable of killing adult and pediatric
2840:
2687:
2647:
2017:
1890:
1771:
1714:
1472:
1421:
528:
293:
1068:
1019:
832:
538:, and is therefore a promising lead compound to develop new antiviral treatment for
60:
2734:
2698:
2582:
2572:
2526:
2522:
2484:
2392:
2182:
2121:
2117:
2098:
2093:
2072:
2061:
1875:
1869:
1855:
1850:
1781:
1776:
1729:
1615:
1482:
1462:
1391:
1340:
1330:
1144:
1136:
524:
512:
508:
496:
472:
95:
90:
588:
Shelton J, Lu X, Hollenbaugh JA, Cho JH, Amblard F, Schinazi RF (December 2016).
170:
2779:
2759:
2744:
2739:
2724:
2682:
2652:
2592:
2562:
2506:
2479:
2352:
2293:
2265:
2255:
2208:
2172:
2088:
2050:
2032:
2027:
2007:
1984:
1955:
1933:
1913:
1903:
1754:
1739:
1719:
1605:
1536:
1522:
1477:
1410:
1405:
1382:
1357:
1325:
1268:
1231:
1208:
1193:
1188:
1173:
605:
2769:
2672:
2667:
2642:
2637:
2627:
2622:
2617:
2587:
2577:
2542:
2537:
2517:
2472:
2460:
2435:
2430:
2420:
2402:
2397:
2387:
2382:
2340:
2328:
2316:
2288:
2275:
2270:
2240:
2203:
2198:
2136:
2131:
2077:
2022:
1974:
1960:
1908:
1895:
1864:
1797:
1786:
1759:
1749:
1744:
1690:
1645:
1640:
1541:
1505:
1437:
1427:
1416:
1400:
1352:
1335:
1311:
1263:
1251:
1203:
905:
888:
816:
771:
718:
353:
201:
1003:
2784:
2764:
2719:
2709:
2703:
2607:
2552:
2501:
2425:
2415:
2370:
2357:
2298:
2260:
2188:
2126:
2067:
2056:
2012:
1969:
1928:
1922:
1918:
1880:
1807:
1802:
1792:
1764:
1724:
1685:
1660:
1650:
1610:
1256:
1246:
1241:
1236:
1198:
475:, being a lipophilic-masked analog of 5-FU that can be administered orally.
54:
1051:
1034:
1011:
976:
914:
873:
824:
789:
736:
687:
623:
1095:
1060:
949:
864:
847:
2693:
2657:
2597:
2365:
2303:
2083:
1979:
1951:
1630:
504:
181:
20:
190:
1586:
1487:
1301:
1162:
156:
887:
Jin Z, Zhao Y, Sun Y, Zhang B, Wang H, Wu Y, et al. (June 2020).
669:
1226:
241:
28:
703:"Acid ceramidase is a novel drug target for pediatric brain tumors"
487:. Once inside a cell, the carmofur prodrug is converted into 5-FU.
376:
367:
75:
527:
patients in China, Japan, and
Finland for many years. Trials and
1108:
266:
442:
1033:
Yamamoto M, Arii S, Sugahara K, Tobe T (March 1996).
2494:
2445:
2225:
2218:
2154:
2108:
2041:
1998:
1835:
1820:
1700:
1670:
1595:
1580:
1551:
1447:
1367:
1310:
1293:
1282:
1218:
1171:
1152:
550:As fluorouracil, carmofur has been known to induce
365:
352:
316:
311:
292:
260:
240:
220:
200:
180:
155:
135:
106:
81:
67:
49:
40:
35:
992:Journal of Neurology, Neurosurgery, and Psychiatry
930:Asia-Oceania Journal of Obstetrics and Gynaecology
169:
144:
583:
581:
579:
1120:
639:
637:
635:
633:
8:
19:
2222:
1832:
1592:
1307:
1290:
1168:
1127:
1113:
1105:
965:Brain and Nerve = Shinkei Kenkyu No Shinpo
303:
280:
209:
27:
1050:
904:
893:Nature Structural & Molecular Biology
863:
779:
726:
677:
613:
229:
127:-hexyl-2,4-dioxo-pyrimidine-1-carboxamide
752:"Acid ceramidase and its inhibitors: a
575:
534:Carmofur has been shown to inhibit the
499:. However, carmofur is a highly potent
463:(1-hexylcarbamoyl-5-fluorouracil) is a
416:
396:
276:
189:
120:
294:
18:
852:Japanese Journal of Clinical Oncology
249:
59:
7:
94:
2867:SARS-CoV-2 main protease inhibitors
1396:ribonucleotide reductase inhibitors
160:
1562:Ribonucleotide reductase inhibitor
1518:Ribonucleotide reductase inhibitor
942:10.1111/j.1447-0756.1989.tb00171.x
14:
1321:Dihydrofolate reductase inhibitor
963:Mizutani T (February 2008). "".
805:Diseases of the Colon and Rectum
337:
334:
328:
485:dihydropyrimidine dehydrogenase
424:Key:AOCCBINRVIKJHY-UHFFFAOYSA-N
1458:Thymidylate synthase inhibitor
1348:Thymidylate synthase inhibitor
1084:Nucleic Acids Symposium Series
1039:The British Journal of Surgery
399:CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
343:
322:
1:
1378:Adenosine deaminase inhibitor
1219:Block microtubule disassembly
471:agent. It is a derivative of
606:10.1021/acs.chemrev.6b00209
2883:
312:Chemical and physical data
2797:
2678:Omacetaxine mepesuccinate
2558:Ciltacabtagene autoleucel
2548:Brexucabtagene autoleucel
906:10.1038/s41594-020-0440-6
817:10.1007/s10350-006-0601-7
772:10.18632/oncotarget.22637
719:10.18632/oncotarget.15800
432:
407:
387:
111:
26:
2730:Talimogene laherparepvec
2663:Nadofaragene firadenovec
2633:Lisocabtagene maraleucel
1582:Topoisomerase inhibitors
1501:DNA polymerase inhibitor
1004:10.1136/jnnp.2007.123737
536:SARS-CoV-2 main protease
61:International Drug Names
2533:Axicabtagene ciloleucel
1137:chemotherapeutic agents
2857:Pyrimidine antagonists
2715:Sitimagene ceradenovec
2613:Idecabtagene vicleucel
2178:Methyl aminolevulinate
1052:10.1002/bjs.1800830313
2189:Porphyrin derivatives
1885:Melphalan flufenamide
1532:Hypomethylating agent
1141:antineoplastic agents
811:(10 Suppl): S82–S91.
766:(68): 112662–112674.
45:5-fluoro-N-hexyl-3,4,
2518:Asparagine depleters
2447:Receptor antagonists
2361:+abiraterone acetate
2568:Denileukin diftitox
2468:Retinoid X receptor
2168:Aminolevulinic acid
1990:Triethylenemelamine
1822:Crosslinking of DNA
1553:Deoxyribonucleotide
1492:+gimeracil/oteracil
865:10.1093/jjco/hyi147
713:(15): 24753–24761.
662:2013NatSR...3E1035R
600:(23): 14379–14455.
552:leukoencephalopathy
491:Mechanism of action
465:pyrimidine analogue
23:
2824:Never to phase III
1626:Etirinotecan pegol
650:Scientific Reports
562:Chemical synthesis
2862:Fluoropyrimidines
2834:
2833:
2793:
2792:
2750:Tigilanol tiglate
2227:Enzyme inhibitors
2150:
2149:
2146:
2145:
1846:Nitrogen mustards
1816:
1815:
1576:
1575:
1278:
1277:
670:10.1038/srep01035
525:colorectal cancer
450:
449:
378:Interactive image
262:CompTox Dashboard
16:Chemical compound
2874:
2847:Pyrimidinediones
2755:Tisagenlecleucel
2512:Arsenic trioxide
2223:
2156:Photosensitizers
1947:Alkyl sulfonates
1861:Cyclophosphamide
1833:
1772:Anthracenediones
1593:
1567:Hydroxycarbamide
1308:
1291:
1169:
1129:
1122:
1115:
1106:
1100:
1099:
1079:
1073:
1072:
1054:
1030:
1024:
1023:
987:
981:
980:
960:
954:
953:
925:
919:
918:
908:
884:
878:
877:
867:
843:
837:
836:
800:
794:
793:
783:
747:
741:
740:
730:
698:
692:
691:
681:
641:
628:
627:
617:
594:Chemical Reviews
585:
503:(AC) inhibitor.
446:
445:
438:
380:
360:
345:
339:
336:
330:
324:
307:
296:
285:
284:
270:
268:
253:
233:
213:
193:
173:
163:
162:
148:
98:
63:
31:
24:
22:
2882:
2881:
2877:
2876:
2875:
2873:
2872:
2871:
2852:Organofluorides
2837:
2836:
2835:
2830:
2829:
2814:Clinical trials
2789:
2495:Other/ungrouped
2490:
2441:
2214:
2194:Porfimer sodium
2142:
2104:
2037:
1994:
1824:
1812:
1696:
1666:
1584:
1572:
1547:
1443:
1363:
1299:
1297:antimetabolites
1295:
1294:DNA precursors/
1286:
1284:DNA replication
1274:
1214:
1184:Vinca alkaloids
1160:
1148:
1133:
1103:
1081:
1080:
1076:
1032:
1031:
1027:
989:
988:
984:
967:(in Japanese).
962:
961:
957:
927:
926:
922:
886:
885:
881:
845:
844:
840:
802:
801:
797:
749:
748:
744:
700:
699:
695:
643:
642:
631:
587:
586:
577:
573:
564:
548:
546:Adverse effects
521:
501:acid ceramidase
493:
481:
441:
439:
436:(what is this?)
433:
428:
425:
420:
415:
414:
403:
400:
395:
394:
383:
358:
348:
342:
333:
327:
288:
264:
256:
236:
216:
196:
176:
159:
151:
131:
128:
119:
118:
102:
70:
17:
12:
11:
5:
2880:
2878:
2870:
2869:
2864:
2859:
2854:
2849:
2839:
2838:
2832:
2831:
2828:
2827:
2826:
2825:
2822:
2811:
2805:
2799:
2798:
2795:
2794:
2791:
2790:
2788:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2701:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2565:
2560:
2555:
2550:
2545:
2540:
2535:
2530:
2514:
2509:
2504:
2498:
2496:
2492:
2491:
2489:
2488:
2476:
2464:
2451:
2449:
2443:
2442:
2440:
2439:
2433:
2428:
2423:
2418:
2406:
2400:
2395:
2390:
2385:
2374:
2368:
2363:
2355:
2348:PARP inhibitor
2344:
2332:
2320:
2308:
2307:
2306:
2301:
2296:
2291:
2279:
2273:
2268:
2263:
2258:
2244:
2231:
2229:
2220:
2216:
2215:
2213:
2212:
2206:
2201:
2196:
2185:
2180:
2175:
2170:
2164:
2162:
2152:
2151:
2148:
2147:
2144:
2143:
2141:
2140:
2134:
2129:
2124:
2114:
2112:
2106:
2105:
2103:
2102:
2096:
2091:
2080:
2075:
2070:
2065:
2053:
2047:
2045:
2039:
2038:
2036:
2035:
2030:
2025:
2020:
2015:
2010:
2004:
2002:
2000:Platinum-based
1996:
1995:
1993:
1992:
1987:
1982:
1977:
1965:
1964:
1958:
1942:
1941:
1936:
1931:
1926:
1916:
1911:
1899:
1898:
1893:
1888:
1878:
1873:
1867:
1858:
1853:
1841:
1839:
1830:
1818:
1817:
1814:
1813:
1811:
1810:
1805:
1800:
1795:
1790:
1784:
1779:
1768:
1762:
1757:
1752:
1747:
1742:
1737:
1727:
1722:
1715:Anthracyclines
1710:
1708:
1698:
1697:
1695:
1694:
1688:
1676:
1674:
1668:
1667:
1665:
1664:
1658:
1653:
1648:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1601:
1599:
1590:
1578:
1577:
1574:
1573:
1571:
1570:
1557:
1555:
1549:
1548:
1546:
1545:
1539:
1527:
1526:
1513:
1512:
1496:
1495:
1485:
1480:
1475:
1470:
1465:
1453:
1451:
1445:
1444:
1442:
1441:
1435:
1433:Mercaptopurine
1424:
1419:
1414:
1408:
1403:
1387:
1386:
1373:
1371:
1365:
1364:
1362:
1361:
1355:
1344:
1338:
1333:
1328:
1316:
1314:
1305:
1288:
1280:
1279:
1276:
1275:
1273:
1272:
1260:
1254:
1249:
1244:
1239:
1234:
1222:
1220:
1216:
1215:
1213:
1212:
1206:
1201:
1196:
1191:
1179:
1177:
1166:
1150:
1149:
1135:Intracellular
1134:
1132:
1131:
1124:
1117:
1109:
1102:
1101:
1074:
1045:(3): 336–340.
1025:
998:(5): 535–539.
982:
971:(2): 137–141.
955:
936:(2): 161–168.
920:
899:(6): 529–532.
879:
858:(9): 536–544.
838:
795:
742:
693:
656:(1035): 1035.
629:
574:
572:
569:
563:
560:
547:
544:
520:
519:Medicinal uses
517:
492:
489:
480:
477:
469:antineoplastic
448:
447:
430:
429:
427:
426:
423:
421:
418:
410:
409:
408:
405:
404:
402:
401:
398:
390:
389:
388:
385:
384:
382:
381:
373:
371:
363:
362:
356:
350:
349:
346:
340:
331:
325:
320:
314:
313:
309:
308:
298:
290:
289:
287:
286:
273:
271:
258:
257:
255:
254:
246:
244:
238:
237:
235:
234:
226:
224:
218:
217:
215:
214:
206:
204:
198:
197:
195:
194:
186:
184:
178:
177:
175:
174:
166:
164:
153:
152:
150:
149:
141:
139:
133:
132:
130:
129:
122:
114:
113:
112:
109:
108:
104:
103:
101:
100:
87:
85:
79:
78:
73:
71:administration
65:
64:
57:
47:
46:
42:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
2879:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2844:
2842:
2823:
2821:
2818:
2817:
2815:
2812:
2809:
2806:
2804:
2801:
2800:
2796:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2705:
2702:
2700:
2696:
2695:
2691:
2689:
2688:Tabelecleucel
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2648:Lurbinectedin
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2551:
2549:
2546:
2544:
2541:
2539:
2536:
2534:
2531:
2528:
2524:
2520:
2519:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2499:
2497:
2493:
2486:
2482:
2481:
2477:
2474:
2470:
2469:
2465:
2462:
2458:
2457:
2453:
2452:
2450:
2448:
2444:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2413:
2411:
2407:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2380:
2379:
2375:
2372:
2369:
2367:
2364:
2362:
2359:
2356:
2354:
2350:
2349:
2345:
2342:
2338:
2337:
2333:
2330:
2326:
2325:
2321:
2318:
2314:
2313:
2309:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2286:
2285:
2284:
2280:
2277:
2274:
2272:
2269:
2267:
2264:
2262:
2259:
2257:
2253:
2252:
2249:
2245:
2242:
2238:
2237:
2233:
2232:
2230:
2228:
2224:
2221:
2217:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2191:
2190:
2186:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2165:
2163:
2161:
2157:
2153:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2119:
2116:
2115:
2113:
2111:
2110:Intercalation
2107:
2100:
2097:
2095:
2092:
2090:
2086:
2085:
2081:
2079:
2076:
2074:
2071:
2069:
2066:
2063:
2059:
2058:
2054:
2052:
2049:
2048:
2046:
2044:
2040:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2018:Dicycloplatin
2016:
2014:
2011:
2009:
2006:
2005:
2003:
2001:
1997:
1991:
1988:
1986:
1983:
1981:
1978:
1976:
1973:
1971:
1967:
1966:
1962:
1959:
1957:
1953:
1950:
1948:
1944:
1943:
1940:
1937:
1935:
1932:
1930:
1927:
1924:
1920:
1917:
1915:
1912:
1910:
1907:
1905:
1901:
1900:
1897:
1894:
1892:
1891:Prednimustine
1889:
1886:
1882:
1879:
1877:
1874:
1871:
1868:
1866:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1843:
1842:
1840:
1838:
1834:
1831:
1828:
1823:
1819:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1788:
1785:
1783:
1780:
1778:
1774:
1773:
1769:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1735:
1731:
1728:
1726:
1723:
1721:
1717:
1716:
1712:
1711:
1709:
1707:
1706:Intercalation
1703:
1699:
1692:
1689:
1687:
1683:
1682:
1678:
1677:
1675:
1673:
1669:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1608:
1607:
1603:
1602:
1600:
1598:
1594:
1591:
1588:
1583:
1579:
1568:
1564:
1563:
1559:
1558:
1556:
1554:
1550:
1543:
1540:
1538:
1534:
1533:
1529:
1528:
1524:
1520:
1519:
1515:
1514:
1510:
1509:+daunorubicin
1507:
1503:
1502:
1498:
1497:
1493:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1473:Doxifluridine
1471:
1469:
1466:
1464:
1460:
1459:
1455:
1454:
1452:
1450:
1446:
1439:
1436:
1434:
1430:
1429:
1425:
1423:
1422:Rabacfosadine
1420:
1418:
1415:
1412:
1409:
1407:
1404:
1402:
1398:
1397:
1393:
1389:
1388:
1384:
1380:
1379:
1375:
1374:
1372:
1370:
1366:
1359:
1356:
1354:
1350:
1349:
1345:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1323:
1322:
1318:
1317:
1315:
1313:
1309:
1306:
1303:
1298:
1292:
1289:
1285:
1281:
1270:
1266:
1265:
1261:
1258:
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1238:
1235:
1233:
1229:
1228:
1224:
1223:
1221:
1217:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1186:
1185:
1181:
1180:
1178:
1175:
1170:
1167:
1164:
1159:
1155:
1151:
1146:
1142:
1138:
1130:
1125:
1123:
1118:
1116:
1111:
1110:
1107:
1097:
1093:
1089:
1085:
1078:
1075:
1070:
1066:
1062:
1058:
1053:
1048:
1044:
1040:
1036:
1029:
1026:
1021:
1017:
1013:
1009:
1005:
1001:
997:
993:
986:
983:
978:
974:
970:
966:
959:
956:
951:
947:
943:
939:
935:
931:
924:
921:
916:
912:
907:
902:
898:
894:
890:
883:
880:
875:
871:
866:
861:
857:
853:
849:
842:
839:
834:
830:
826:
822:
818:
814:
810:
806:
799:
796:
791:
787:
782:
777:
773:
769:
765:
761:
757:
755:
746:
743:
738:
734:
729:
724:
720:
716:
712:
708:
704:
697:
694:
689:
685:
680:
675:
671:
667:
663:
659:
655:
651:
647:
640:
638:
636:
634:
630:
625:
621:
616:
611:
607:
603:
599:
595:
591:
584:
582:
580:
576:
570:
568:
561:
559:
555:
553:
545:
543:
541:
537:
532:
530:
529:meta-analyses
526:
518:
516:
514:
513:glioblastomas
510:
506:
502:
498:
490:
488:
486:
478:
476:
474:
470:
466:
462:
458:
454:
444:
437:
431:
422:
417:
413:
406:
397:
393:
386:
379:
375:
374:
372:
369:
364:
357:
355:
351:
321:
319:
315:
310:
306:
302:
299:
297:
295:ECHA InfoCard
291:
283:
279:
278:DTXSID2045941
275:
274:
272:
263:
259:
252:
248:
247:
245:
243:
239:
232:
228:
227:
225:
223:
219:
212:
208:
207:
205:
203:
199:
192:
188:
187:
185:
183:
179:
172:
168:
167:
165:
158:
154:
147:
143:
142:
140:
138:
134:
126:
121:
117:
110:
105:
97:
92:
89:
88:
86:
84:
80:
77:
74:
72:
66:
62:
58:
56:
52:
48:
43:
39:
36:Clinical data
34:
30:
25:
2735:Tazemetostat
2699:Alitretinoin
2692:
2603:Estramustine
2583:Elsamitrucin
2573:Eflornithine
2527:Pegaspargase
2523:Asparaginase
2516:
2485:Testolactone
2478:
2466:
2454:
2408:
2393:Panobinostat
2376:
2346:
2334:
2322:
2310:
2281:
2246:
2234:
2187:
2183:Padeliporfin
2122:Dactinomycin
2118:Streptomyces
2099:Temozolomide
2094:Mitozolomide
2082:
2073:Mitobronitol
2062:Procarbazine
2055:
2043:Nonclassical
1968:
1945:
1939:Streptozocin
1904:Nitrosoureas
1902:
1876:Chlorambucil
1870:Trofosfamide
1856:Chlormethine
1851:Bendamustine
1844:
1782:Mitoxantrone
1777:Losoxantrone
1770:
1730:Daunorubicin
1713:
1679:
1616:Camptothecin
1604:
1560:
1530:
1516:
1499:
1483:Fluorouracil
1467:
1463:Capecitabine
1456:
1426:
1390:
1376:
1346:
1341:Pralatrexate
1331:Methotrexate
1319:
1262:
1225:
1182:
1087:
1083:
1077:
1042:
1038:
1028:
995:
991:
985:
968:
964:
958:
933:
929:
923:
896:
892:
882:
855:
851:
841:
808:
804:
798:
763:
759:
753:
745:
710:
706:
696:
653:
649:
597:
593:
565:
556:
549:
533:
522:
509:temozolomide
494:
482:
473:fluorouracil
460:
452:
451:
440:
434:
251:ChEMBL460499
124:
2810:from market
2780:Vorasidenib
2760:Trabectedin
2745:Tiazofurine
2740:Tebentafusp
2725:Tagraxofusp
2683:Plitidepsin
2653:Mitoguazone
2593:Epacadostat
2563:Demecolcine
2507:Aflibercept
2480:Sex steroid
2353:Fuzuloparib
2294:Carfilzomib
2266:Palbociclib
2256:Abemaciclib
2209:Verteporfin
2173:Efaproxiral
2089:Dacarbazine
2051:Altretamine
2033:Satraplatin
2028:Oxaliplatin
2008:Carboplatin
1985:Triaziquone
1956:Mannosulfan
1934:Ranimustine
1914:Fotemustine
1755:Pirarubicin
1740:Doxorubicin
1734:+cytarabine
1720:Aclarubicin
1681:Podophyllum
1606:Camptotheca
1537:Azacitidine
1523:Gemcitabine
1478:Floxuridine
1411:Fludarabine
1406:Clofarabine
1392:Halogenated
1383:Pentostatin
1358:Raltitrexed
1326:Aminopterin
1269:Ixabepilone
1264:Epothilones
1232:Cabazitaxel
1209:Vinorelbine
1194:Vincristine
1189:Vinblastine
1174:microtubule
1090:(18): 1–4.
467:used as an
361: g·mol
301:100.216.315
107:Identifiers
41:Other names
2841:Categories
2775:Verdinexor
2770:Venetoclax
2673:Oblimersen
2668:Navitoclax
2643:Lucanthone
2638:Lonidamine
2628:Lifileucel
2623:Ivosidenib
2618:Imetelstat
2588:Enasidenib
2578:Elesclomol
2543:Bexarotene
2538:Belzutifan
2473:Bexarotene
2461:Atrasentan
2436:Umbralisib
2431:Idelalisib
2421:Copanlisib
2403:Vorinostat
2398:Romidepsin
2388:Entinostat
2383:Belinostat
2341:Masoprocol
2329:Tiazofurin
2317:Anagrelide
2289:Bortezomib
2276:Seliciclib
2271:Ribociclib
2251:inhibitors
2241:Tipifarnib
2204:Temoporfin
2199:Talaporfin
2137:Plicamycin
2132:Mitomycins
2078:Pipobroman
2057:Hydrazines
2023:Nedaplatin
1975:Carboquone
1970:Aziridines
1961:Treosulfan
1909:Carmustine
1896:Uramustine
1865:Ifosfamide
1837:Alkylating
1798:Bisantrene
1787:Pixantrone
1760:Valrubicin
1750:Idarubicin
1745:Epirubicin
1691:Teniposide
1646:Lurtotecan
1641:Irinotecan
1542:Decitabine
1506:Cytarabine
1449:Pyrimidine
1438:Tioguanine
1428:Thiopurine
1417:Nelarabine
1401:Cladribine
1353:Pemetrexed
1336:Pemetrexed
1312:Folic acid
1252:Paclitaxel
1204:Vinflunine
760:Oncotarget
707:Oncotarget
571:References
366:3D model (
354:Molar mass
231:HA82M3RAB2
202:ChemSpider
146:61422-45-5
137:CAS Number
116:IUPAC name
2820:Phase III
2808:Withdrawn
2785:Vosaroxin
2765:Veliparib
2720:Sotorasib
2710:Selinexor
2704:Tretinoin
2694:Retinoids
2608:Glasdegib
2553:Celecoxib
2502:Adagrasib
2426:Duvelisib
2416:Alpelisib
2371:Rucaparib
2358:Niraparib
2299:Oprozomib
2261:Alvocidib
2127:Bleomycin
2084:Triazenes
2068:Etoglucid
2013:Cisplatin
1929:Nimustine
1923:Semustine
1919:Lomustine
1881:Melphalan
1808:Menogaril
1803:Crisnatol
1793:Amsacrine
1765:Zorubicin
1725:Amrubicin
1686:Etoposide
1661:Topotecan
1656:Silatecan
1651:Rubitecan
1636:Gimatecan
1621:Cositecan
1611:Belotecan
1287:inhibitor
1257:Tesetaxel
1247:Ortataxel
1242:Larotaxel
1237:Docetaxel
1199:Vindesine
123:5-fluoro-
69:Routes of
55:Drugs.com
2658:Mitotane
2598:Eribulin
2366:Olaparib
2304:Ixazomib
1980:Thiotepa
1952:Busulfan
1631:Exatecan
1468:Carmofur
1176:assembly
1139: /
1069:28134419
1020:38293604
1012:17682013
977:18306661
915:32382072
874:16155120
833:30655861
825:17106820
790:29348854
737:28445970
688:23301156
624:27960273
558:the US.
540:COVID-19
505:Ceramide
453:Carmofur
443:(verify)
182:DrugBank
83:ATC code
21:Carmofur
1587:S phase
1488:Tegafur
1302:S phase
1227:Taxanes
1163:M phase
1096:3697106
1061:8665186
950:2667512
781:5762539
754:de novo
728:5421885
679:3539145
658:Bibcode
615:7717319
479:Biology
359:257.265
318:Formula
191:DB09010
157:PubChem
99:)
93: (
91:L01BC04
2803:WHO-EM
2412:(Pi3K)
1369:Purine
1172:Block
1094:
1067:
1059:
1018:
1010:
975:
948:
913:
872:
831:
823:
788:
778:
735:
725:
686:
676:
622:
612:
392:SMILES
242:ChEMBL
2324:IMPDI
2219:Other
1065:S2CID
1016:S2CID
829:S2CID
459:) or
412:InChI
368:JSmol
2410:PIKI
2378:HDAC
1827:CCNS
1092:PMID
1057:PMID
1008:PMID
973:PMID
946:PMID
911:PMID
870:PMID
821:PMID
786:PMID
733:PMID
684:PMID
620:PMID
497:5–FU
461:HCFU
222:UNII
211:2479
171:2577
76:Oral
51:AHFS
2456:ERA
2312:PhI
2283:PrI
2248:CDK
2160:PDT
1158:MIs
1154:SPs
1145:L01
1047:doi
1000:doi
938:doi
901:doi
860:doi
813:doi
776:PMC
768:doi
723:PMC
715:doi
674:PMC
666:doi
610:PMC
602:doi
598:116
457:INN
267:EPA
161:CID
96:WHO
2843::
2816::
2336:LI
2236:FI
1702:II
1672:II
1494:))
1088:18
1086:.
1063:.
1055:.
1043:83
1041:.
1037:.
1014:.
1006:.
996:79
994:.
969:60
944:.
934:15
932:.
909:.
897:27
895:.
891:.
868:.
856:35
854:.
850:.
827:.
819:.
809:49
807:.
784:.
774:.
762:.
758:.
731:.
721:.
709:.
705:.
682:.
672:.
664:.
652:.
648:.
632:^
618:.
608:.
596:.
592:.
578:^
542:.
515:.
332:16
326:11
2706:)
2697:(
2529:)
2525:/
2521:(
2487:)
2483:(
2475:)
2471:(
2463:)
2459:(
2438:)
2414:(
2405:)
2381:(
2373:)
2351:(
2343:)
2339:(
2331:)
2327:(
2319:)
2315:(
2278:)
2254:(
2243:)
2239:(
2211:)
2192:(
2158:/
2139:)
2120:(
2101:)
2087:(
2064:)
2060:(
1972::
1963:)
1954:(
1949::
1925:)
1921:(
1906::
1887:)
1883:(
1872:)
1863:(
1848::
1829:)
1825:(
1789:)
1775:(
1767:)
1736:)
1732:(
1718:(
1704:+
1693:)
1684:(
1663:)
1609:(
1597:I
1589:)
1585:(
1569:)
1565:(
1544:)
1535:(
1525:)
1521:(
1511:)
1504:(
1490:(
1461:(
1440:)
1431:(
1413:)
1399:(
1394:/
1385:)
1381:(
1360:)
1351:(
1343:)
1324:(
1304:)
1300:(
1271:)
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