169:
year. Although Croce publicly stated that he was given no reason for his removal as chair, OSU produced a letter that provided such reasons, including that Croce "failed to provide appropriate evaluation and guidance for the faculty", "has been resistant to following normal procedures for developing faculty letters of offer and determining salary parameters", "has also not met some of the basic chair responsibilities regarding governance of the
Department", and "is deficient in his ability to manage university and department finances". Regarding the latter, OSU has reported that Croce "mismanaged funds and engaged in non-compliance in clinical trials".
192:(NIH) returned a funding application that contained major portions identical to an application submitted months earlier by Croce's junior colleague. OSU later cleared Croce of misconduct after accusations that he had patented a researcher's work without providing proper credit, that members of his lab had inappropriately used grant money for personal trips abroad, and that Croce improperly pressured colleagues for research attribution. Since 2013, several scientists have claimed research misconduct on the part of Croce, and as of 2020 these allegations remain under investigation by the federal
319:
188:, including image and data manipulation. While working at Jefferson, federal investigators alleged Croce and a colleague had submitted false claims for research never undertaken. The university settled the allegations, paying $ 2.6 million to the government without admitting any wrongdoing. In 2007, OSU investigated Croce for misconduct after the
289:
the law firm James E. Arnold & Associates, of
Columbus, OH, for over $ 690,000 in unpaid legal fees associated with Croce's lawsuits related to his scientific misconduct. In December 2022, Croce was ordered by the Franklin County (OH) Court of Common Pleas to pay Kegler Brown Hill + Ritter over one million dollars for unpaid invoices.
875:
Garofalo, Michela; Romano, Giulia; Di Leva, Gianpiero; Nuovo, Gerard; Jeon, Young-Jun; Ngankeu, Apollinaire; Sun, Jin; Lovat, Francesca; Alder, Hansjuerg; Condorelli, Gerolama; Engelman, Jeffrey A.; Ono, Mayumi; Rho, Jin Kyung; Cascione, Luciano; Volinia, Stefano; Nephew, Kenneth P.; Croce, Carlo M.
281:
and
Sanders cases, with appellate judges in the latter case writing that Croce's "papers contained problems outside the range of acceptable research." In 2019 Croce lost a lawsuit he brought against Ohio State University to be reinstated as chair of the Department of Cancer Genetics and Biology, and
694:
Trapasso, Francesco; Pichiorri, Flavia; Gaspari, Marco; Palumbo, Tiziana; Aqeilan, Rami I.; Gaudio, Eugenio; Okumura, Hiroshi; Iuliano, Rodolfo; Leva, Giampiero Di; Fabbri, Muller; Birk, David E.; Raso, Cinzia; Green-Church, Kari; Spagnoli, Luigi G.; Venuta, Salvatore; Huebner, Kay; Croce, Carlo M.
168:
In 2016, Croce was paid more than $ 850,000 by Ohio State. In 2019, Croce was removed as chair of the
Department of Cancer Biology and Genetics at OSU, and he subsequently sued OSU to be reinstated. His request for a temporary restraining order was denied but he retained his salary of $ 804,461 per
288:
In June 2020, Croce, who has been described by
Sanders as "a serial plaintiff", was sued by the law firm Kegler Brown Hill + Ritter, of Columbus, OH, for $ 923,445.51 in unpaid fees associated with Croce's defamation lawsuits related to his scientific misconduct. In January 2021, Croce was sued by
276:
article. In May 2020 Croce lost the defamation lawsuit against
Sanders (within the deposition phase of which Croce stated, "I am considered like the Pope of the genetics of leukemias and lymphomas."), with the presiding judge writing that "iscovery has proved the existence of about 30 instances of
263:
and several of its writers and editors for defamation, invasion of privacy, and intentional infliction of emotional distress based on their reporting of the scientific misconduct allegations. In
November 2018, United States District Judge James Graham dismissed virtually all of Croce's lawsuit. In
309:
paintings, with a claimed ability to identify and purchase genuine masters for a fraction of their worth. In 2023 Croce's art collection was ordered by the state of Ohio to be sold in order to pay Croce's nearly $ 1.1 million debt to lawyers who represented him in his failed libel and defamation
245:
inquiry over scientific misconduct in Croce's lab resulted in the identification of a number of cases, including plagiarism and data-falsification, affecting publications by two researchers of the lab. Croce himself was not found guilty of research misconduct, but investigators criticized his
925:
Pichiorri, F.; Suh, S. S.; Rocci, A.; De Luca, L.; Taccioli, C.; Santhanam, R.; Zhou, W.; Benson, D. M.; Hofmainster, C.; Alder, H.; Garofalo, M.; Di Leva, G.; Volinia, S.; Lin, H. J.; Perrotti, D.; Kuehl, M.; Aqeilan, R. I.; Palumbo, A.; Croce, C. M. (2022).
196:(ORI). Members of the scientific community have pointed out the "tremendous conflict of interest" attached to OSU's investigations of Croce, as Croce's federal research funding includes $ 8.7 million provided directly to the university in overhead costs.
208:
1054:
Garofalo, M.; Di Leva, G.; Romano, G.; Nuovo, G.; Suh, S. S.; Ngankeu, A.; Taccioli, C.; Pichiorri, F.; Alder, H.; Secchiero, P.; Gasparini, P.; Gonelli, A.; Costinean, S.; Acunzo, M.; Condorelli, G.; Croce, C. M. (2022).
1708:
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gene contained manipulated western blots, but in 2017 the journal agreed to correct the paper after consulting with experts. In 2016, Croce was found to have plagiarized a paper he published in
549:
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534:
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retracted a paper Croce had published in 2010 after it learned that images had been copied from a 2008 paper published in another journal. Also in 2017, the
928:"Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development"
800:
249:
As of 2024, 15 of Croce's research publications have been retracted, five others have received an expression of concern, and 23 others have been corrected.
1703:
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147:) to argue that lung cancer was an inherited condition. While at Jefferson, Croce and his research team discovered in 2002 a role of microRNAs in cancer
1346:
123:
and associate director of the Wistar
Institute, and from 1988-1991 he was director of the Fels Institute for Cancer Research and Molecular Biology at
1212:
203:
of image manipulation in over 30 research papers, OSU instructed Croce to correct or retract some of his research publications; in 2015, the journal
1278:
376:
331:
1129:
878:"Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers"
1252:
355:
579:
672:
1302:
339:
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124:
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and the molecular mechanisms underlying cancer. Croce and his research have attracted public attention because of multiple allegations of
650:
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158:(OSU), where he had been an external advisor since 1988, receiving an initial salary of $ 475,000 and taking with him over 100 staff.
1586:
1057:"Retraction Notice to: MiR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation"
625:
346:. In 2017, Croce received the Margaret Foti Award from the AACR for Leadership and Extraordinary Achievements in Cancer Research.
323:
1658:"Dr. Carlo Croce Recognized With 2017 AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research"
246:
management, and OSU told him to retract multiple additional papers. Subsequently four additional articles have been retracted
224:
161:
In 2013, Croce resigned from the Ri.MED Foundation's scientific committee due to its director's support for the controversial
1698:
220:
200:
189:
697:"Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells"
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132:
112:
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234:, both colleagues and co-authors with Croce on two papers each, were found to have engaged in scientific misconduct.
120:
1397:
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509:
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128:
782:
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301:, lacks culture, motivating him to spend more of his time traveling than on campus. Croce privately collects
1506:
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1303:
https://retractionwatch.com/2020/05/13/cancer-researcher-loses-defamation-suit-against-critic/#more-119450
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550:"OSU cancer researcher who has faced misconduct allegations sues to regain lost department chairmanship"
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of
Biology and Anatomy in Philadelphia. In 1980, Croce was named Wistar Professor of Genetics at the
1230:
820:"Exclusive: investigators found plagiarism and data falsification in work from prominent cancer lab"
285:
Croce also sued OSU to be reinstated as department chair. Croce lost that suit on summary judgment.
302:
857:
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Croce's research and publications have been scrutinized by the scientific community for possible
1482:"Law firm sues OSU cancer researcher for $ 900,000 in unpaid fees following failed libel suit"
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fabrication or duplication" in Croce's research papers." Croce lost his appeals in both the
238:
116:
1562:"Judge orders cancer researcher's art collection seized to pay fees from failed libel suit"
143:. During that time, tobacco companies used Croce's research into fragile histidine triad (
1040:
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231:
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1536:"Judge orders OSU cancer researcher to pay $ 1 million to lawyers from failed libel suit"
1426:"Embattled cancer researcher loses legal bid to be reinstated as department chair at OSU"
1373:"Embattled cancer researcher loses legal bid to be reinstated as department chair at OSU"
1456:"A scientist critic was sued, and won — but did not emerge unscathed. This is his story"
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535:"Ohio State cancer researcher Carlo Croce's 7th paper withdrawn; university in review"
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1307:
https://retractionwatch.com/wp-content/uploads/2020/05/judgment-opinion-and-order.pdf
861:
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issued a correction after being contacted on the matter by a newspaper. In 2014, the
64:
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342:. In 2011, he received the Award for Excellence in Molecular Diagnostics from the
227:
retracted a paper Croce had published in 2008 due to image/figure irregularities.
1001:
139:’s scientific advisory board, where he remained until the group closed after the
1072:
977:"Retraction: Akt Regulates Drug-Induced Cell Death through BCL-w Downregulation"
943:
420:
1279:"Ohio State Cancer Researcher Accused of Falsifying Data Loses Defanation Suit"
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209:
Proceedings of the
National Academy of Sciences of the United States of America
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673:"Journal retracts paper due to image mismatch; one co-author alleges fraud"
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115:. His research career in the United States began the following year at the
1130:"Retraction count for Italian researcher swells to 15 as five papers fall"
1144:"Alfredo Fusco, facing misconduct charges in Italy, up to 21 retractions"
335:
216:
90:
85:(born December 17, 1944) is an Italian-American professor of medicine at
580:"Carlo Croce loses a round in legal bid to be reinstated as dep't chair"
306:
377:"Prominent Scientist Switches Labs, Sparking Administrative Fireworks"
1195:"Why The Ohio State University decided to go public about misconduct"
651:"When does "overlap" become plagiarism? Here's what PLOS ONE decided"
127:. In 1991, Croce was named Director of the Kimmel Cancer Center at
317:
60:
1347:"Litigious OSU professor loses appeal in federal defamation case"
425:"Years of Ethics Charges, but Star Cancer Researcher Gets a Pass"
212:
144:
1253:"'Star' Ohio State Cancer Researcher Loses Defamation Action"
230:
In 2018, two cancer researchers at OSU, Samson T. Jacob and
172:
Croce has received over $ 86 million in federal grants as a
1507:"Franklin County Ohio Clerk of Courts of the Common Please"
626:"OSU department chair forced to step down without a reason"
176:, with $ 29.1 million received since he joined Ohio State.
1213:"Judge dismisses most of Carlo Croce's libel case against
330:
In 2006 Croce received the Clowes Memorial Award from the
264:
2017 Croce also filed a defamation lawsuit against critic
1709:
Members of the United States National Academy of Sciences
1612:"Academy Home - American Academy of Arts & Sciences"
453:"Ohio State's Carlo M. Croce - A Macro View of MicroRNA"
801:"OSU Professor Falsified Data on Eight Papers, Resigns"
1592:. American Association for Cancer Research. April 2006
1319:"United States Court of Appeals for the Sixth Circuit"
484:"OSU lures scientist to lead cancer genetics program"
211:
dismissed a challenge that Croce's 2005 paper on the
334:for his discoveries of the molecular mechanisms of
199:In 2013, following accusations from science critic
70:
56:
28:
21:
747:"Croce cm AND jacob st - Search Results - PubMed"
765:"Croce cm AND chen cs - Search Results - PubMed"
282:in 2021 Croce lost the appeal of that decision.
219:from six separate sources. In 2017, the journal
1724:Fellows of the American Academy of Microbiology
257:On May 10, 2017, Croce filed a lawsuit against
326:is given by The Queen of the Belgians to Croce
8:
1729:Members of the National Academy of Medicine
1277:Raudins, Sam; Szilagy, Sarah (2020-05-14).
135:in Philadelphia. In 1994, Croce joined the
338:. In 2010, he was elected a fellow of the
18:
1080:
1010:
1000:
951:
901:
843:
722:
712:
180:Investigations into scientific misconduct
578:Oransky, Author Ivan (4 February 2019).
332:American Association for Cancer Research
1177:"Croce v. New York Times Company et al"
783:"Cancer biologist retracts five papers"
415:
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411:
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399:
397:
367:
356:List of scientific misconduct incidents
1036:
1026:
606:
596:
375:Dickinson, Susan L-J (June 24, 1991).
16:Italian–American professor of medicine
1305:The 12th May 2020 Opinion and Order.
1111:. The Center for Scientific Integrity
624:Moberger, Alexis (28 November 2018).
573:
571:
569:
510:"Leaked Files Slam Stem-Cell Therapy"
423:; Agustin Armendariz (9 March 2017).
340:American Academy of Arts and Sciences
7:
1251:Pazanowski, Mary Anne (2020-05-13).
125:Temple University School of Medicine
1638:Association for Molecular Pathology
1587:"AACR-G.H.A. Clowes Memorial Award"
818:Van Noorden, Richard (2022-07-20).
482:Leonard, Martha (August 23, 2004).
344:Association for Molecular Pathology
141:Tobacco Master Settlement Agreement
1704:Sapienza University of Rome alumni
1371:Oransky, Ivan (18 December 2019).
508:Abbott, Alison (January 7, 2014).
14:
1568:. Center for Scientific Integrity
1542:. Center for Scientific Integrity
1534:Kincaid, Ellie (9 January 2023).
1516:. Center for Scientific Integrity
1488:. Center for Scientific Integrity
1462:. Center for Scientific Integrity
1407:. Center for Scientific Integrity
1379:. Center for Scientific Integrity
1353:. Center for Scientific Integrity
1345:Oransky, Ivan (4 February 2021).
324:Artois-Baillet Latour Foundation
1436:from the original on 2021-11-05
701:Journal of Biological Chemistry
225:Journal of Biological Chemistry
1233:. PacerMonitor LLC. 2017-04-20
1146:. Retraction Watch. 2018-12-24
221:Cell Death and Differentiation
113:La Sapienza University of Rome
1:
1560:Kincaid, Ellie (2023-06-12).
190:National Institutes of Health
1480:Oransky, Ivan (2020-06-26).
1181:Justia Dockets & Filings
1002:10.1371/journal.pone.0267621
194:Office of Research Integrity
137:Council for Tobacco Research
1719:Fellows of the AACR Academy
1454:Oransky, Ivan (July 2021).
1166:courthousenews.com May 2017
1105:"Retraction Watch Database"
1073:10.1016/j.ccell.2022.10.005
944:10.1016/j.ccell.2022.10.006
548:Marcus, Adam (2019-01-10).
241:reported that the internal
133:Thomas Jefferson University
1745:
1259:. Bloomberg Industry Group
894:10.1038/s41591-022-02044-2
845:10.1038/d41586-022-02002-5
121:University of Pennsylvania
1285:. The Lantern Media Group
975:PLOS ONE Editors (2022).
129:Jefferson Medical College
205:Clinical Cancer Research
154:In 2004, Croce moved to
105:Croce graduated in 1969
714:10.1074/jbc.A117.709062
488:Columbus Business First
1398:"Croce-v-OSU-decision"
327:
322:The 2013 prize of the
174:principal investigator
1699:Physicians from Milan
321:
186:scientific misconduct
156:Ohio State University
95:scientific misconduct
87:Ohio State University
463:(2): 3–4. March 2008
272:, who was quoted in
101:Education and career
1714:Italian oncologists
993:2022PLoSO..1767621.
836:2022Natur.607..650V
653:. 16 September 2016
303:Italian Renaissance
1231:"Croce v. Sanders"
1219:. 8 November 2018.
1215:The New York Times
1039:has generic name (
695:(25 August 2017).
609:has generic name (
430:The New York Times
328:
274:The New York Times
260:The New York Times
89:, specializing in
1634:"Past Recipients"
830:(7920): 650–652.
675:. 24 January 2017
537:. September 2017.
270:Purdue University
151:and progression.
111:in medicine from
83:Carlo Maria Croce
80:
79:
43:December 17, 1944
33:Carlo Maria Croce
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789:. 14 March 2018.
787:Retraction Watch
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1201:. 5 April 2018.
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987:(4): e0267621.
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297:Croce has said
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232:Ching-Shih Chen
182:
163:Stamina therapy
108:summa cum laude
103:
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1616:www.amacad.org
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1432:. 2019-12-18.
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1199:Science | AAAS
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279:New York Times
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237:In July 2022,
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23:Carlo M. Croce
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