196:, a Leukemia drug. Her research team used leukemia samples from before treatment with venetoclax and following their resistance. They then analyzed the tissue looking for genomic differences in the before and after relapse samples. The results of the analysis were lacking so they performed a large-scale loss-of-function screen to see the effect on other genes. Through this screening, they found that resistant cells make too much
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In 2011, Wu was the recipient of a Stand Up To Cancer
Innovative Research Grant for her project "Coupled Genetic and Functional Dissection of Chronic Lymphocytic Leukemia." Using this grant, she identified mutations in the splicing factor SF3B1 connected to the development of
173:. Wu later led a study analyzing genetic material in CLL and normal tissue of over 500 patients. Her research team identified numerous genetic abnormalities that had the ability to drive leukemia, including RPS15 and IKZF3 which had never before been linked to human cancer.
188:. They found that genetic changes that occur very early in chronic lymphocytic leukaemia development directly influenced the growth pattern the CLL cells would ultimately take. As a result of her research, she was elected a Member of the
200:. Using a similar approach, Wu also studies how to implement personalized cancer vaccines by identifying neoantigen targets created by a patient's tumor. This immunotherapeutic effort is applicable to blood and solid tumor malignancies.
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In 2019, Wu continued her research on patients with chronic lymphocytic leukaemia and led a research study which collaborated with scientists at the
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In 2000, Wu joined the Dana-Farber faculty and began her independent research program in 2005.
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224:"Oncology Researcher Catherine J. Wu, MD, Always Knew She Wanted to Be a Doctor"
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192:. Wu later led a study which uncovered why some patients become resistant to
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and completed her medical fellowship in oncology and hematology at the
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when she was in grade school. Growing up, she attended
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Wu was born in New York City but her family moved to
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