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Catherine S. Woolley

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215:. In 2013, Woolley was appointed to the William Deering Chair in Biological Sciences in the Department of Neurobiology, Weinberg College of Arts & Sciences, Northwestern University. She is the founding Director of Northwestern University's undergraduate Neuroscience program, and was named a Charles Deering McCormick Professor of Teaching Excellence by Northwestern in 2018 for "transforming the landscape of undergraduate education in Weinberg." 308:"Catherine is finding the same neuronotrophic activation by steroids whether she uses Golgi staining to count spines or the electron microscope to visualize synapses. The methods are more sophisticated and powerful, but the basic observation is the same." Cortical Explorer Award, 2000 275:
increased the number and density of excitatory synapses of CA1 pyramidal cells in the rat hippocampus, as well as the density of dendritic spines. Both estradiol and spine density fluctuated dramatically during the estrous cycle. Woolley recognized that this suggested that the adult brain was subject
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Woolley studies cellular and molecular neuroscience in relation to the brain and behavior, particularly neuroendocrinology and the plasticity of neural circuits. She attempts to understand molecular mechanisms of estrogen and its interactions with the structure and function of synapses in the adult
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While the significance of these results for humans are not yet demonstrated, rats are often used as a model for studying humans. An important implication of Woolley's research is that drug testing on males should not be assumed to yield results applicable to both males and females. To understand
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and their roles as neuromodulators of brain development and function. In 2012, Woolley published research showing that estrogens had differential effects in the brains of female and male rats, decreasing inhibitory synaptic transmission in female rats but not in males. In 2015, her group reported
346:, lessening the release of neurotransmitters. In male rats, the drug had no effect. The interaction did not reflect circulating reproductive hormones. Further research is needed to determine the extent to which rat neurology provides an accurate model for human neurology. 147:
caused structural changes to cells in the rat hippocampus. She has also shown that neuronal mechanisms in the rat brain differ in males and females. Her work has broad significance for drug development and women's health, and for the studies of
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brain, and their behavioral consequences. She has been described as "a leading authority in a very exciting area of adult neuroplasticity". Her earliest work included a pioneering study demonstrating that
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to change, at least in rats; this was surprising because it was accepted at that time that the adult brain was structurally stable. Woolley's 1990 work is considered a pioneering study in hormones and
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in Seattle, with Philip Schwartzkroin. There she applied electrophysiology techniques and ultrastructural analysis to the study of hormonal effects in the brain. She studied the effects of
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Spencer, Joanna L.; Waters, Elizabeth M.; Romeo, Russell D.; Wood, Gwendolyn E.; Milner, Teresa A.; McEwen, Bruce S. (May 2008).
326: 260: 389: 401: 1550: 430: 280:. Further work established that the manipulation of female sex hormones affects hippocampal structure in adult rats. 224: 136: 304:. In 2000, she received the Cortical Explorer Award in recognition of her work on neuroanatomy and brain activity. 360: 1175:"Issues in Clinical Epileptology: A View from the Bench. A Festschrift in Honor of Philip A. Schwartzkroin, PhD" 1067:(the black reaction), which showed the whole nerve cell, including its cell body, axon, and branching dendrites. 962: 317:
As a professor at Northwestern University, Woolley has done ongoing research into the sex-specific effects of
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Lifting depression : a neuroscientist's hands-on approach to activating your brain's healing power
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Woolley, CS (1999). "Electrophysiological and cellular effects of estrogen on neuronal function".
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2018: Charles Deering McCormick Professor of Teaching Excellence, Northwestern University
1347:"Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity" 1420: 1395: 1371: 1346: 1322: 1297: 1273: 1248: 1199: 1174: 1151: 1108: 1099: 1016: 1007: 991: 839:(Fourth ed.). Baltimore, MD: Lippincott Williams & Wilkins. pp. 555–558. 745: 720: 1574: 721:"Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research" 268: 253: 933: 382:
2007–2009: Pioneer Award, Women's Health Research Institute, Northwestern University
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studies stress and its impact on the brain. With McEwen, Woolley initially studied
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Gould, Elizabeth; Woolley, Catherine S.; Frankfurt, Maya; McEwen, Bruce S. (1990).
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and was given a prize by the university for the best undergraduate honors thesis.
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Wissman, Anne Marie; May, Renee M.; Woolley, Catherine S. (11 October 2011).
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Origins of neuroscience : a history of explorations into brain function
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2013: William Deering Chair in Biological Sciences, Northwestern University
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that male and female rats differ in the molecular pathways affected by
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Bear, Mark F.; Connors, Barry W.; Paradiso, Michael A., eds. (2007).
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with Philip Schwartzkroin in the Department of Neurological Surgery.
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In 1873, Golgi published the first brief but "adequate" picture of
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2019: Gill Center Transformative Research Award, Indiana University
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Woolley, CS; Gould, E; Frankfurt, M; McEwen, BS (December 1990).
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Shansky, Rebecca M.; Woolley, Catherine S. (23 November 2016).
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Between 1993 and 1998, Woolley worked as a postdoc at the
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increased the inhibitory effect of the endocannabinoid
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2000: Cortical Explorer Award, Krieg Awards, Cajal Club
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drug action, effects on both sexes should be studied.
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Huang, Guang Zhe; Woolley, Catherine S. (June 2012).
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Distinguished Young Scholar in Medical Research Award
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Molecular mechanisms of hormone actions on behavior
168:Catherine S. Woolley was born on July 30, 1965, in 106: 92: 77: 63: 39: 32: 521: 519: 259:levels. Woolley went on to work with McEwen and 985: 983: 620: 618: 616: 614: 612: 306: 878: 876: 425: 423: 421: 419: 417: 263:on a 1990 study that examined the brain using 207:In 1998, she became an assistant professor at 956: 954: 8: 1636:Members of the National Academy of Medicine 625:Garcia-Segura, Luis Miguel (May 5, 2009). 567: 492: 490: 488: 486: 484: 29: 1419: 1370: 1321: 1272: 1222:Etgen, Anne M.; Pfaff, Donald W. (2009). 1198: 1107: 1015: 744: 714: 712: 710: 592: 565: 563: 561: 559: 557: 555: 553: 551: 549: 547: 457: 455: 453: 451: 1226:. Elsevier/Academic Press. p. 43. 1043:. Oxford University Press. p. 45. 837:Neuroscience : exploring the brain 826: 824: 808:Weinberg College of Arts & Sciences 413: 222:(2014–2018). She is a senior editor of 862: 852: 657: 655: 218:She was elected to the Council of the 1247:Galanopoulou, Aristea S. (May 2013). 388:2016: Transformative Research Award, 7: 1173:Stafstrom, Carl E. (December 2013). 127:(born July 30, 1965) is an American 1474:American Association of Anatomists 1470:"Past & Current award Winners" 1152:10.1615/CritRevNeurobiol.v13.i1.10 1100:10.1523/JNEUROSCI.10-04-01286.1990 1008:10.1523/JNEUROSCI.10-12-04035.1990 378:American Association of Anatomists 25: 1555:www.neurobiology.northwestern.edu 1249:"Stirring the Pot With Estrogens" 774:. Basic Books. pp. 124–125. 662:Shah, Aparna (October 29, 2015). 267:, a technique first described by 1140:Critical Reviews in Neurobiology 327:metabotropic glutamate receptors 1616:Texas A&M University alumni 1611:Northwestern University faculty 1302:Frontiers in Neuroendocrinology 961:McEwen, Robert (11 July 2017). 271:in 1873. The study showed that 1606:21st-century American chemists 1601:American women neuroscientists 963:"When is stress good for you?" 737:10.1523/JNEUROSCI.1390-16.2016 1: 1626:People from Nelsonville, Ohio 1621:Rockefeller University alumni 628:Hormones and brain plasticity 531:National Institutes of Health 467:Fralin Life Science Institute 390:National Institutes of Health 18:Catherine Woolley (scientist) 1412:10.1016/j.neuron.2012.03.035 1351:Brain Structure and Function 402:National Academy of Medicine 400:2019: Elected Member of the 139:at Northwestern University. 1631:21st-century American women 1526:"Faculty Honors and Awards" 1314:10.1016/j.yfrne.2007.08.006 1088:The Journal of Neuroscience 996:The Journal of Neuroscience 938:The Journal of Neuroscience 725:The Journal of Neuroscience 631:. Oxford University Press. 574:"Krieg Cortical Kudos 2000" 572:Azmitia, Efrain C. (2000). 225:The Journal of Neuroscience 137:Feinberg School of Medicine 1652: 1265:10.5698/1535-7511-13.3.129 1191:10.5698/1535-7597-13.6.291 376:2007: C.J. Herrick Award, 361:Alfred P. Sloan Foundation 338:. In female rats the drug 81:Neurobiology and neurology 1363:10.1007/s00429-011-0353-6 180:, with a B.Sc. honors in 118: 85: 1596:American neuroscientists 1500:"Fellows & Scholars" 1448:Philanthropy News Digest 1039:Finger, Stanley (1994). 913:Society for Neuroscience 290:University of Washington 284:University of Washington 220:Society for Neuroscience 202:University of Washington 174:Texas A&M University 101:University of Washington 72:Texas A&M University 1591:American women chemists 1530:Northwestern University 1504:Northwestern University 888:Northwestern University 768:Lambert, Kelly (2010). 594:10.1093/cercor/10.8.826 435:Northwestern University 313:Northwestern University 209:Northwestern University 133:Northwestern University 97:Northwestern University 934:"2018 Editorial Board" 909:"Volunteer Leadership" 310: 246:Rockefeller University 237:Rockefeller University 198:Rockefeller University 178:College Station, Texas 68:Rockefeller University 371:W. M. Keck Foundation 252:and their effects on 192:Woolley studied with 172:. She graduated from 802:Stein, Anne (2014). 668:PLOS Neuro Community 129:neuroendocrinologist 125:Catherine S. Woolley 34:Catherine S. Woolley 1450:. December 24, 2009 833:"Sex and the brain" 731:(47): 11817–11822. 431:"Catherine Woolley" 278:synaptic plasticity 694:Northweastern News 296:on the release of 27:American biologist 1253:Epilepsy Currents 1179:Epilepsy Currents 884:"2018 Recipients" 504:. August 14, 2015 354:Awards and honors 329:, and endogenous 170:Nelsonville, Ohio 122: 121: 87:Scientific career 57:Nelsonville, Ohio 16:(Redirected from 1643: 1565: 1564: 1562: 1561: 1547: 1541: 1540: 1538: 1536: 1522: 1516: 1515: 1513: 1511: 1496: 1490: 1489: 1487: 1485: 1476:. 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Index

Catherine Woolley (scientist)
Nelsonville, Ohio
Rockefeller University
Texas A&M University
Northwestern University
University of Washington
Doctoral advisor
Bruce McEwen
neuroendocrinologist
Northwestern University
Feinberg School of Medicine
estrogen
epilepsy
anxiety
depression
Nelsonville, Ohio
Texas A&M University
College Station, Texas
zoology
Bruce McEwen
Rockefeller University
University of Washington
Northwestern University
Evanston
Society for Neuroscience
The Journal of Neuroscience
Bruce McEwen
Rockefeller University
neuroleptics
proenkephalin

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