650:
627:
40:
1095:
984:
31:
2705:
725:
1155:
Following expiration of the
Bristol-Myers Squibb patent, cefepime became available as a generic and is now marketed by numerous companies worldwide under tradenames including Neopime (Neomed), Maxipime, Cepimax, Cepimex, and Axepim.
1208:
934:
Cefepime is a broad-spectrum cephalosporin antibiotic and has been used to treat bacteria responsible for causing pneumonia and infections of the skin and urinary tract. Some of these bacteria include
290:
1420:
777:
InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
1220:
2434:
245:
1413:
139:
1297:
Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert
Committee on the selection and use of essential medicines
749:
1073:
moiety increases penetration into Gram-negative bacteria. These factors increase the activity of cefepime against otherwise resistant organisms including
1406:
2659:
856:
1259:
2725:
1173:
Yahav D, Paul M, Fraser A, Sarid N, Leibovici L (May 2007). "Efficacy and safety of cefepime: a systematic review and meta-analysis".
1253:
1142:
1031:
769:
947:
1581:
1521:
1510:
406:
275:
171:
2578:
2464:
1120:
1009:
1355:
2695:
1630:
1320:
Chapman TM, Perry CM (2003). "Cefepime: a review of its use in the management of hospitalized patients with pneumonia".
1216:
838:
526:
2676:
2489:
2409:
1536:
1470:
606:
1105:
994:
190:
1398:
1124:
1109:
1013:
998:
2414:
1541:
1292:
1116:
1005:
1437:
906:
2343:
926:, cefepime is stable and is a front-line agent when infection with Enterobacteriaceae is known or suspected.
2664:
2479:
2439:
1546:
1454:
834:
238:
227:
645:
2503:
2454:
2444:
876:
2745:
2735:
2484:
2469:
2449:
900:
595:
2568:
2474:
2419:
1356:"Cefepime Susceptibility and Concentration Range (μg/ml) Minimum Inhibitory Concentration (MIC) Data"
845:
372:
622:
2459:
2429:
2278:
2240:
441:
234:
1281:"Cefepime (maxipime), large spectrum 4th generation cephalosporin, resistant to beta-lactamases]".
2740:
2730:
1055:
911:
201:
575:
1994:
1700:
1475:
1337:
1249:
1243:
1190:
327:
314:
302:
149:
129:
515:
2582:
1733:
1531:
1329:
1300:
1182:
825:, with greater activity against both types of organism than third-generation agents. A 2007
662:
337:
92:
57:
535:
450:
2709:
2370:
1814:
1641:
359:
345:
649:
626:
1387:
39:
2670:
1600:
1059:
923:
830:
1186:
2719:
2564:
2423:
2232:
2199:
2064:
2038:
1971:
1883:
1866:
1778:
1772:
1718:
1714:
1684:
1679:
1674:
1669:
1659:
1595:
1566:
1556:
826:
819:
815:
808:
736:
638:
351:
163:
475:
2333:
2250:
2093:
1951:
1936:
1742:
1571:
1445:
1441:
849:
258:
253:
2645:
2623:
2592:
2586:
2512:
2392:
2382:
2268:
2260:
2245:
2159:
2129:
2124:
2119:
2114:
2109:
2088:
2077:
2049:
2043:
1999:
1961:
1941:
1926:
1874:
1752:
1709:
1650:
1616:
1591:
1561:
1551:
1429:
1366:
1094:
1070:
983:
888:
157:
2633:
2628:
2596:
2572:
2543:
2521:
2387:
2360:
2310:
2291:
2222:
2212:
2174:
2164:
2154:
2139:
2134:
2082:
2053:
2019:
2009:
1989:
1946:
1916:
1911:
1901:
1870:
1796:
1768:
1747:
1723:
1664:
1655:
1496:
919:
868:
811:
701:
506:
841:(FDA) performed their own meta-analysis which found no mortality difference.
2640:
2526:
2377:
2355:
2328:
2323:
2318:
2296:
2286:
2217:
2188:
2179:
2149:
2104:
2028:
2023:
2014:
2004:
1984:
1956:
1931:
1921:
1906:
1896:
1891:
1851:
1846:
1839:
1828:
1818:
1809:
1690:
1611:
1606:
1433:
881:
871:
385:
143:
1341:
1194:
30:
2616:
2183:
2169:
2144:
2099:
2072:
2033:
1979:
1834:
1823:
822:
486:
185:
22:
2520:
Insert into bacterial cell wall causing perforation and depolarization:
1305:
495:
1333:
1049:
915:
885:
461:
2366:
1862:
1067:
586:
390:
950:
susceptibility data for a few medically significant microorganisms:
874:, infections caused by multiple drug-resistant microorganisms (e.g.
555:
2351:
1800:
1500:
1052:
833:
was increased in people treated with cefepime compared with other
724:
715:
566:
364:
894:
Cefepime has good activity against important pathogens including
546:
308:
1402:
321:
180:
1088:
977:
113:
78:
611:
848:
and approved for medical use in 1994. It is available as a
757:
O=C2N1/C(=C(\CS12NC(=O)C(=N\OC)/c3nc(sc3)N)C4(C)CCCC4)C()=O
284:
212:
101:
66:
867:
Cefepime is usually reserved to treat moderate to severe
107:
72:
1309:. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
1058:
and the aminothiazole moiety confers extra stability to
814:. Cefepime has an extended spectrum of activity against
297:
857:
794:
428:
7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-
2693:
2435:
Benzathine benzylpenicillin/procaine benzylpenicillin
104:
98:
69:
63:
914:. Whereas other cephalosporins are degraded by many
430:
3-((1-methylpyrrolidinium-1-yl)methyl)-8-oxo-5-thia-
110:
75:
2606:
2556:
2535:
2511:
2502:
2402:
2342:
2309:
2277:
2259:
2231:
2198:
2063:
1970:
1882:
1861:
1795:
1761:
1732:
1699:
1640:
1629:
1580:
1520:
1509:
1495:
1453:
852:and sold under a variety of trade names worldwide.
735:
713:
700:
661:
656:
637:
605:
585:
565:
545:
525:
505:
485:
460:
440:
397:
384:
371:
358:
344:
336:
274:
269:
244:
226:
200:
170:
156:
138:
128:
116:
95:
81:
60:
51:
46:
910:. A particular strength is its activity against
474:
449:
1414:
829:suggested when data of trials were combined,
8:
1209:"FDA Alert: Cefepime (marketed as Maxipime)"
189:
21:
1123:. Unsourced material may be challenged and
1012:. Unsourced material may be challenged and
2508:
1879:
1637:
1517:
1506:
1492:
1421:
1407:
1399:
648:
625:
514:
16:Fourth-generation Cephalosporin Antibiotic
2542:Inhibits PG elongation and crosslinking:
1304:
1143:Learn how and when to remove this message
1032:Learn how and when to remove this message
534:
1322:American Journal of Respiratory Medicine
1213:Information for Healthcare Professionals
1062:enzymes produced by many bacteria. The
2700:
1165:
774:
754:
621:
494:
411:
162:
1248:. John Wiley & Sons. p. 496.
639:
20:
1299:. Geneva: World Health Organization.
594:
574:
148:
7:
1394:. U.S. National Library of Medicine.
1121:adding citations to reliable sources
1010:adding citations to reliable sources
930:Spectrum of bacterial susceptibility
432:1-aza-bicyclooct-2-ene-2-carboxylate
257:
554:
465:
946:species. The following represents
14:
2567:subunit synthesis and transport:
1262:from the original on 19 June 2021
844:Cefepime was patented in 1982 by
2703:
1093:
982:
741:150 °C (302 °F) (dec.)
679:
673:
91:
56:
38:
29:
1242:Fischer J, Ganellin CR (2006).
1175:The Lancet. Infectious Diseases
782:Key:HVFLCNVBZFFHBT-ZKDACBOMSA-N
2465:Imipenem/cilastatin/relebactam
904:, and multiple drug-resistant
691:
685:
667:
1:
1245:Analogue-based Drug Discovery
1187:10.1016/S1473-3099(07)70109-3
1365:. toku-e.com. Archived from
1217:Food and Drug Administration
839:Food and Drug Administration
2490:Ticarcillin/clavulanic acid
2410:Amoxicillin/clavulanic acid
1547:Phenoxymethylpenicillin (V)
1537:Benzathine benzylpenicillin
2762:
657:Chemical and physical data
2726:Cephalosporin antibiotics
2654:
2415:Ampicillin/flucloxacillin
1542:Procaine benzylpenicillin
1293:World Health Organization
790:
765:
745:
402:
37:
28:
967:Streptococcus pneumoniae
907:Streptococcus pneumoniae
855:It was removed from the
837:. In response, the U.S.
2480:Piperacillin/tazobactam
2440:Cefepime/enmetazobactam
1392:Drug Information Portal
1363:The Antimicrobial Index
1044:The combination of the
969:: ≤0.007 – >8 μg/ml
807:is a fourth-generation
2571:synthesis inhibition (
2455:Ceftolozane/tazobactam
2445:Cefoperazone/sulbactam
2344:β-lactamase inhibitors
1075:Pseudomonas aeruginosa
1048:-configuration of the
963:: 0.06 – >256 μg/ml
961:Pseudomonas aeruginosa
896:Pseudomonas aeruginosa
877:Pseudomonas aeruginosa
2485:Sulbactam/durlobactam
2470:Meropenem/vaborbactam
2450:Ceftazidime/avibactam
1582:β-lactamase resistant
1522:β-lactamase sensitive
1079:Staphylococcus aureus
901:Staphylococcus aureus
2475:Panipenem/betamipron
2420:Ampicillin/sulbactam
1532:Benzylpenicillin (G)
1466:cell wall by binding
1117:improve this section
1006:improve this section
957:: ≤0.007 – 128 μg/ml
846:Bristol-Myers Squibb
835:β-lactam antibiotics
2460:Imipenem/cilastatin
2430:Aztreonam/avibactam
2241:Ceftaroline fosamil
1372:on 1 November 2018.
317:(Prescription only)
293:(Prescription only)
25:
2681:Never to phase III
2613:Hydrolyze NAM-NAG
1701:Carboxypenicillins
1464:layer of bacterial
1460:(inhibit synthesis
1334:10.1007/bf03256641
1223:on 2 November 2017
912:Enterobacteriaceae
2691:
2690:
2552:
2551:
2498:
2497:
2305:
2304:
2087:Antipseudomonal (
1995:Cefuroxime axetil
1791:
1790:
1787:
1786:
1734:Ureidopenicillins
1625:
1624:
1489:
1482:
1478:
1468:to and inhibiting
1153:
1152:
1145:
1042:
1041:
1034:
802:
801:
726:Interactive image
607:CompTox Dashboard
325:
312:
300:
288:
216:
183:
2753:
2708:
2707:
2706:
2699:
2509:
1880:
1736:(4th generation)
1703:(4th generation)
1644:(3rd generation)
1642:Aminopenicillins
1638:
1585:(2nd generation)
1525:(1st generation)
1518:
1507:
1493:
1488:
1480:
1476:
1462:of peptidoglycan
1458:
1423:
1416:
1409:
1400:
1395:
1374:
1373:
1371:
1360:
1352:
1346:
1345:
1317:
1311:
1310:
1308:
1289:
1283:
1282:
1278:
1272:
1271:
1269:
1267:
1239:
1233:
1232:
1230:
1228:
1219:. Archived from
1205:
1199:
1198:
1170:
1148:
1141:
1137:
1134:
1128:
1097:
1089:
1037:
1030:
1026:
1023:
1017:
986:
978:
955:Escherichia coli
798:
797:
728:
708:
693:
687:
681:
675:
669:
652:
641:
630:
629:
615:
613:
598:
578:
558:
538:
518:
498:
478:
468:
467:
453:
376:
323:
320:
310:
307:
299:
296:
286:
283:
261:
214:
211:
193:
182:
179:
166:
152:
123:
122:
119:
118:
115:
112:
109:
106:
103:
100:
97:
88:
87:
84:
83:
80:
77:
74:
71:
68:
65:
62:
42:
33:
26:
24:
2761:
2760:
2756:
2755:
2754:
2752:
2751:
2750:
2716:
2715:
2714:
2704:
2702:
2694:
2692:
2687:
2686:
2671:Clinical trials
2650:
2602:
2548:
2531:
2494:
2398:
2371:Clavulanic acid
2338:
2301:
2273:
2255:
2227:
2194:
2059:
1966:
1873:
1869:
1865:
1857:
1815:Antipseudomonal
1783:
1757:
1728:
1695:
1632:
1621:
1584:
1576:
1524:
1512:
1485:transpeptidases
1484:
1474:
1469:
1467:
1465:
1463:
1461:
1459:
1457:
1449:
1427:
1386:
1383:
1378:
1377:
1369:
1358:
1354:
1353:
1349:
1319:
1318:
1314:
1291:
1290:
1286:
1280:
1279:
1275:
1265:
1263:
1256:
1241:
1240:
1236:
1226:
1224:
1207:
1206:
1202:
1172:
1171:
1167:
1162:
1149:
1138:
1132:
1129:
1114:
1098:
1087:
1038:
1027:
1021:
1018:
1003:
987:
976:
932:
924:beta-lactamases
865:
793:
791:
786:
783:
778:
773:
772:
761:
758:
753:
752:
731:
706:
696:
690:
684:
678:
672:
633:
609:
601:
581:
561:
541:
521:
501:
481:
464:
456:
436:
433:
431:
429:
427:
410:
409:
374:
346:Bioavailability
338:Pharmacokinetic
332:
265:
229:
222:
203:
196:
94:
90:
59:
55:
17:
12:
11:
5:
2759:
2757:
2749:
2748:
2743:
2738:
2733:
2728:
2718:
2717:
2713:
2712:
2689:
2688:
2685:
2684:
2683:
2682:
2679:
2668:
2662:
2656:
2655:
2652:
2651:
2649:
2648:
2643:
2638:
2637:
2636:
2631:
2621:
2620:
2619:
2610:
2608:
2604:
2603:
2601:
2600:
2590:
2576:
2560:
2558:
2554:
2553:
2550:
2549:
2547:
2546:
2539:
2537:
2533:
2532:
2530:
2529:
2524:
2517:
2515:
2506:
2500:
2499:
2496:
2495:
2493:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2447:
2442:
2437:
2432:
2427:
2417:
2412:
2406:
2404:
2400:
2399:
2397:
2396:
2390:
2385:
2380:
2376:non-β-lactam (
2374:
2364:
2358:
2348:
2346:
2340:
2339:
2337:
2336:
2331:
2326:
2321:
2315:
2313:
2307:
2306:
2303:
2302:
2300:
2299:
2294:
2289:
2283:
2281:
2275:
2274:
2272:
2271:
2265:
2263:
2257:
2256:
2254:
2253:
2248:
2243:
2237:
2235:
2233:5th generation
2229:
2228:
2226:
2225:
2220:
2215:
2210:
2204:
2202:
2200:4th generation
2196:
2195:
2193:
2192:
2186:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2091:
2085:
2080:
2075:
2069:
2067:
2065:3rd generation
2061:
2060:
2058:
2057:
2047:
2041:
2036:
2031:
2026:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1982:
1976:
1974:
1972:2nd generation
1968:
1967:
1965:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1894:
1888:
1886:
1884:1st generation
1877:
1867:Cephalosporins
1859:
1858:
1856:
1855:
1849:
1843:
1837:
1832:
1826:
1821:
1812:
1805:
1803:
1793:
1792:
1789:
1788:
1785:
1784:
1782:
1781:
1776:
1765:
1763:
1759:
1758:
1756:
1755:
1750:
1745:
1739:
1737:
1730:
1729:
1727:
1726:
1721:
1712:
1706:
1704:
1697:
1696:
1694:
1693:
1688:
1682:
1677:
1672:
1667:
1662:
1653:
1647:
1645:
1635:
1627:
1626:
1623:
1622:
1620:
1619:
1614:
1609:
1604:
1601:Flucloxacillin
1598:
1588:
1586:
1578:
1577:
1575:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1528:
1526:
1515:
1504:
1490:
1451:
1450:
1432:active on the
1430:Antibacterials
1428:
1426:
1425:
1418:
1411:
1403:
1397:
1396:
1382:
1381:External links
1379:
1376:
1375:
1347:
1312:
1284:
1273:
1254:
1234:
1200:
1181:(5): 338–348.
1164:
1163:
1161:
1158:
1151:
1150:
1133:September 2019
1101:
1099:
1092:
1086:
1083:
1040:
1039:
1022:September 2019
990:
988:
981:
975:
972:
971:
970:
964:
958:
931:
928:
864:
861:
800:
799:
788:
787:
785:
784:
781:
779:
776:
768:
767:
766:
763:
762:
760:
759:
756:
748:
747:
746:
743:
742:
739:
733:
732:
730:
729:
721:
719:
711:
710:
704:
698:
697:
694:
688:
682:
676:
670:
665:
659:
658:
654:
653:
643:
635:
634:
632:
631:
623:DTXSID70873208
618:
616:
603:
602:
600:
599:
591:
589:
583:
582:
580:
579:
571:
569:
563:
562:
560:
559:
551:
549:
543:
542:
540:
539:
531:
529:
523:
522:
520:
519:
511:
509:
503:
502:
500:
499:
491:
489:
483:
482:
480:
479:
471:
469:
458:
457:
455:
454:
446:
444:
438:
437:
435:
434:
413:
405:
404:
403:
400:
399:
395:
394:
388:
382:
381:
378:
369:
368:
362:
356:
355:
348:
342:
341:
334:
333:
331:
330:
318:
305:
294:
280:
278:
272:
271:
267:
266:
264:
263:
250:
248:
242:
241:
232:
230:administration
224:
223:
221:
220:
218:
208:
206:
198:
197:
195:
194:
176:
174:
168:
167:
160:
154:
153:
146:
136:
135:
134:Maxipime, Voco
132:
126:
125:
53:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
2758:
2747:
2744:
2742:
2739:
2737:
2734:
2732:
2729:
2727:
2724:
2723:
2721:
2711:
2701:
2697:
2680:
2678:
2675:
2674:
2672:
2669:
2666:
2663:
2661:
2658:
2657:
2653:
2647:
2644:
2642:
2639:
2635:
2632:
2630:
2627:
2626:
2625:
2622:
2618:
2615:
2614:
2612:
2611:
2609:
2605:
2598:
2594:
2591:
2588:
2584:
2580:
2577:
2574:
2570:
2566:
2562:
2561:
2559:
2557:Intracellular
2555:
2545:
2541:
2540:
2538:
2534:
2528:
2525:
2523:
2519:
2518:
2516:
2514:
2510:
2507:
2505:
2501:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2428:
2425:
2424:Sultamicillin
2421:
2418:
2416:
2413:
2411:
2408:
2407:
2405:
2401:
2394:
2391:
2389:
2386:
2384:
2381:
2379:
2375:
2372:
2368:
2365:
2362:
2359:
2357:
2353:
2350:
2349:
2347:
2345:
2341:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2316:
2314:
2312:
2308:
2298:
2295:
2293:
2290:
2288:
2285:
2284:
2282:
2280:
2276:
2270:
2267:
2266:
2264:
2262:
2258:
2252:
2249:
2247:
2244:
2242:
2239:
2238:
2236:
2234:
2230:
2224:
2221:
2219:
2216:
2214:
2211:
2209:
2206:
2205:
2203:
2201:
2197:
2190:
2187:
2185:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2095:
2092:
2090:
2086:
2084:
2081:
2079:
2076:
2074:
2071:
2070:
2068:
2066:
2062:
2055:
2051:
2048:
2045:
2042:
2040:
2039:Cefbuperazone
2037:
2035:
2032:
2030:
2027:
2025:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1981:
1978:
1977:
1975:
1973:
1969:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1889:
1887:
1885:
1881:
1878:
1876:
1872:
1868:
1864:
1860:
1853:
1850:
1848:
1844:
1841:
1838:
1836:
1833:
1830:
1827:
1825:
1822:
1820:
1816:
1813:
1811:
1808:Carbapenems (
1807:
1806:
1804:
1802:
1798:
1794:
1780:
1779:Sulbenicillin
1777:
1774:
1773:Pivmecillinam
1770:
1767:
1766:
1764:
1760:
1754:
1751:
1749:
1746:
1744:
1741:
1740:
1738:
1735:
1731:
1725:
1722:
1720:
1719:Carindacillin
1716:
1715:Carbenicillin
1713:
1711:
1708:
1707:
1705:
1702:
1698:
1692:
1689:
1686:
1685:Talampicillin
1683:
1681:
1680:Metampicillin
1678:
1676:
1675:Lenampicillin
1673:
1671:
1670:Bacampicillin
1668:
1666:
1663:
1661:
1660:Pivampicillin
1657:
1654:
1652:
1649:
1648:
1646:
1643:
1639:
1636:
1634:
1628:
1618:
1615:
1613:
1610:
1608:
1605:
1602:
1599:
1597:
1596:Dicloxacillin
1593:
1590:
1589:
1587:
1583:
1579:
1573:
1570:
1568:
1567:Clometocillin
1565:
1563:
1560:
1558:
1557:Pheneticillin
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1530:
1529:
1527:
1523:
1519:
1516:
1514:
1508:
1505:
1502:
1498:
1494:
1491:
1486:
1472:
1456:
1452:
1447:
1443:
1439:
1435:
1431:
1424:
1419:
1417:
1412:
1410:
1405:
1404:
1401:
1393:
1389:
1385:
1384:
1380:
1368:
1364:
1357:
1351:
1348:
1343:
1339:
1335:
1331:
1328:(1): 75–107.
1327:
1323:
1316:
1313:
1307:
1302:
1298:
1294:
1288:
1285:
1277:
1274:
1261:
1257:
1255:9783527607495
1251:
1247:
1246:
1238:
1235:
1222:
1218:
1214:
1210:
1204:
1201:
1196:
1192:
1188:
1184:
1180:
1176:
1169:
1166:
1159:
1157:
1147:
1144:
1136:
1126:
1122:
1118:
1112:
1111:
1107:
1102:This section
1100:
1096:
1091:
1090:
1084:
1082:
1080:
1076:
1072:
1069:
1065:
1061:
1057:
1054:
1051:
1047:
1036:
1033:
1025:
1015:
1011:
1007:
1001:
1000:
996:
991:This section
989:
985:
980:
979:
973:
968:
965:
962:
959:
956:
953:
952:
951:
949:
945:
944:Streptococcus
941:
937:
929:
927:
925:
921:
917:
913:
909:
908:
903:
902:
897:
892:
890:
887:
884:treatment of
883:
879:
878:
873:
870:
862:
860:
858:
853:
851:
847:
842:
840:
836:
832:
828:
827:meta-analysis
824:
821:
820:Gram-negative
817:
816:Gram-positive
813:
810:
809:cephalosporin
806:
796:
789:
780:
775:
771:
764:
755:
751:
744:
740:
738:
737:Melting point
734:
727:
723:
722:
720:
717:
712:
705:
703:
699:
666:
664:
660:
655:
651:
647:
644:
642:
640:ECHA InfoCard
636:
628:
624:
620:
619:
617:
608:
604:
597:
593:
592:
590:
588:
584:
577:
573:
572:
570:
568:
564:
557:
553:
552:
550:
548:
544:
537:
533:
532:
530:
528:
524:
517:
513:
512:
510:
508:
504:
497:
493:
492:
490:
488:
484:
477:
473:
472:
470:
463:
459:
452:
448:
447:
445:
443:
439:
425:
421:
417:
412:
408:
401:
396:
392:
389:
387:
383:
379:
377:
370:
366:
363:
361:
357:
353:
349:
347:
343:
339:
335:
329:
319:
316:
306:
304:
295:
292:
282:
281:
279:
277:
273:
268:
260:
255:
252:
251:
249:
247:
243:
240:
239:intramuscular
236:
233:
231:
225:
219:
210:
209:
207:
205:
199:
192:
187:
178:
177:
175:
173:
169:
165:
161:
159:
155:
151:
147:
145:
141:
137:
133:
131:
127:
121:
86:
54:
52:Pronunciation
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
2746:Oxime ethers
2736:Pyrrolidines
2595:inhibitors (
2585:inhibitors (
2513:Lipopeptides
2504:Polypeptides
2403:Combinations
2334:Nocardicin A
2251:Ceftobiprole
2207:
2094:Cefoperazone
1952:Cefaloridine
1937:Cefaloglycin
1875:Carbacephems
1743:Piperacillin
1572:Penamecillin
1473:, a group of
1391:
1367:the original
1362:
1350:
1325:
1321:
1315:
1306:10665/325773
1296:
1287:
1276:
1266:19 September
1264:. Retrieved
1244:
1237:
1225:. Retrieved
1221:the original
1212:
1203:
1178:
1174:
1168:
1154:
1139:
1130:
1115:Please help
1103:
1078:
1074:
1063:
1045:
1043:
1028:
1019:
1004:Please help
992:
966:
960:
954:
943:
939:
935:
933:
905:
899:
895:
893:
875:
866:
854:
850:generic drug
843:
804:
803:
792:
576:CHEBI:478164
423:
419:
415:
373:Elimination
276:Legal status
270:Legal status
172:License data
18:
2667:from market
2646:Teixobactin
2624:Tyrothricin
2593:bactoprenol
2587:Cycloserine
2393:Vaborbactam
2383:Durlobactam
2311:Monobactams
2269:Cefiderocol
2261:Siderophore
2246:Ceftolozane
2160:Cefpimizole
2130:Cefpodoxime
2125:Cefpiramide
2120:Cefmenoxime
2115:Ceftizoxime
2110:Cefdaloxime
2089:Ceftazidime
2078:Ceftriaxone
2050:Carbacephem
2044:Cefmetazole
2000:Cefamandole
1962:Cefatrizine
1942:Cefacetrile
1927:Cefroxadine
1871:Cephamycins
1797:Carbapenems
1753:Mezlocillin
1710:Ticarcillin
1651:Amoxicillin
1617:Methicillin
1592:Cloxacillin
1562:Azidocillin
1552:Propicillin
1497:Penicillins
1085:Trade names
1071:pyrrolidine
1060:β-lactamase
940:Escherichia
936:Pseudomonas
889:neutropenia
863:Medical use
709: g·mol
646:100.171.025
398:Identifiers
235:Intravenous
158:MedlinePlus
130:Trade names
2720:Categories
2634:Tyrocidine
2629:Gramicidin
2597:Bacitracin
2573:Fosfomycin
2544:Ramoplanin
2522:Daptomycin
2388:Relebactam
2361:Tazobactam
2292:Cefquinome
2279:Veterinary
2223:Cefquinome
2213:Cefozopran
2175:Ceftiolene
2165:Cefsulodin
2155:Cefodizime
2140:Cefditoren
2135:Ceftibuten
2083:Cefotaxime
2054:Loracarbef
2020:Cephamycin
2010:Ceforanide
1990:Cefuroxime
1947:Cefalonium
1917:Cefazaflur
1912:Cefazedone
1902:Cefadroxil
1769:Mecillinam
1748:Azlocillin
1724:Temocillin
1665:Hetacillin
1656:Ampicillin
1388:"Cefepime"
1160:References
922:-mediated
920:chromosome
869:nosocomial
812:antibiotic
714:3D model (
702:Molar mass
536:807PW4VQE3
507:ChemSpider
451:88040-23-7
442:CAS Number
407:IUPAC name
360:Metabolism
2741:Thiazoles
2731:Ketoximes
2677:Phase III
2665:Withdrawn
2641:Isoniazid
2527:Surfactin
2378:Avibactam
2356:Sulbactam
2329:Carumonam
2324:Tigemonam
2319:Aztreonam
2297:Cefovecin
2287:Ceftiofur
2218:Cefpirome
2189:Latamoxef
2180:Oxacephem
2150:Cefetamet
2105:Cefcapene
2029:Cefotetan
2024:Cefoxitin
2015:Cefuzonam
2005:Cefonicid
1985:Cefprozil
1957:Cefalotin
1932:Ceftezole
1922:Cefradine
1907:Cefapirin
1897:Cefalexin
1892:Cefazolin
1852:Ritipenem
1847:Faropenem
1840:Panipenem
1829:Meropenem
1819:Doripenem
1810:Ertapenem
1691:Epicillin
1612:Nafcillin
1607:Oxacillin
1455:β-lactams
1434:cell wall
1104:does not
993:does not
974:Chemistry
882:empirical
872:pneumonia
859:in 2019.
831:mortality
596:ChEMBL186
386:Excretion
375:half-life
228:Routes of
202:Pregnancy
150:Monograph
144:Drugs.com
2710:Medicine
2617:lysozyme
2563:Inhibit
2208:Cefepime
2184:Flomoxef
2170:Cefteram
2145:Cefotiam
2100:Cefdinir
2073:Cefixime
2034:Cefminox
1980:Cefaclor
1845:Penems (
1835:Biapenem
1824:Imipenem
1633:spectrum
1631:Extended
1513:spectrum
1483:-alanine
1479:-alanyl-
1438:envelope
1342:14720024
1295:(2019).
1260:Archived
1227:2 August
1195:17448937
823:bacteria
805:Cefepime
795:(verify)
487:DrugBank
246:ATC code
217: B1
204:category
191:Cefepime
186:DailyMed
23:Cefepime
1863:Cephems
1125:removed
1110:sources
1050:methoxy
1014:removed
999:sources
916:plasmid
886:febrile
663:Formula
516:4586395
496:DB01413
476:5479537
462:PubChem
380:2 hours
365:Hepatic
301::
262:)
256: (
254:J01DE01
188::
164:a698021
2696:Portal
2660:WHO-EM
2367:Clavam
1801:Penems
1511:Narrow
1501:Penams
1340:
1252:
1193:
1068:methyl
1056:moiety
942:, and
918:- and
880:) and
750:SMILES
707:480.56
587:ChEMBL
556:D02376
393:70–99%
350:100% (
328:℞-only
326:
313:
303:℞-only
289:
184:
124:
2607:Other
2579:DADAL
2536:Other
2352:Penam
1762:Other
1370:(PDF)
1359:(PDF)
1053:imino
770:InChI
716:JSmol
567:ChEBI
391:Renal
1471:PBPs
1446:J01D
1442:J01C
1436:and
1338:PMID
1268:2020
1250:ISBN
1229:2009
1191:PMID
1108:any
1106:cite
1077:and
997:any
995:cite
818:and
547:KEGG
527:UNII
340:data
140:AHFS
2569:NAM
1330:doi
1301:hdl
1183:doi
1119:by
1046:syn
1008:by
948:MIC
612:EPA
466:CID
367:15%
315:POM
259:WHO
89:or
2722::
2673::
2583:AR
2565:PG
1799:/
1717:/
1390:.
1361:.
1336:.
1324:.
1258:.
1215:.
1211:.
1189:.
1177:.
1081:.
938:,
898:,
891:.
677:24
671:19
426:)-
418:,7
414:(6
352:IM
322:US
309:UK
298:CA
291:S4
285:AU
237:,
213:AU
181:US
114:iː
79:iː
2698::
2599:)
2589:)
2581:/
2575:)
2426:)
2422:(
2395:)
2373:)
2369:(
2363:)
2354:(
2191:)
2182:(
2096:)
2056:)
2052:(
2046:)
2022:(
1854:)
1842:)
1831:)
1817:(
1775:)
1771:(
1687:)
1658:(
1603:)
1594:(
1503:)
1499:(
1487:)
1481:D
1477:D
1448:)
1444:-
1440:(
1422:e
1415:t
1408:v
1344:.
1332::
1326:2
1303::
1270:.
1231:.
1197:.
1185::
1179:7
1146:)
1140:(
1135:)
1131:(
1127:.
1113:.
1066:-
1064:N
1035:)
1029:(
1024:)
1020:(
1016:.
1002:.
718:)
695:2
692:S
689:5
686:O
683:6
680:N
674:H
668:C
614:)
610:(
424:Z
422:,
420:R
416:R
354:)
324::
311::
287::
215::
142:/
120:/
117:m
111:p
108:ɪ
105:f
102:ɛ
99:k
96:ˈ
93:/
85:/
82:m
76:p
73:ɪ
70:f
67:ɛ
64:s
61:ˈ
58:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
