248:
173:
1356:
24:
1088:
Byun JY, Kim MJ, Eum DY, Yoon CH, Seo WD, Park KH, et al. (October 2009). "Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells".
130:
1044:
Zhu H, Liu XW, Cai TY, Cao J, Tu CX, Lu W, et al. (August 2010). "Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway".
1132:
Avilla J, Teixidò A, Velázquez C, Alvarenga N, Ferro E, Canela R (January 2000). "Insecticidal activity of
Maytenus species (Celastraceae) nortriterpene quinone methides against codling moth, Cydia pomonella (L.) (Lepidoptera: tortricidae)".
1167:
Kyriakou E, Schmidt S, Dodd GT, et al. Celastrol
Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus. J Med Chem. 2018;61(24):11144-11157.
271:
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
281:
InChI=1/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
809:
Kim DH, Shin EK, Kim YH, Lee BW, Jun JG, Park JH, Kim JK (September 2009). "Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from
Celastrus regelii".
766:
Allison AC, Cacabelos R, Lombardi VR, Alvarez XA, Vigo C (October 2001). "Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for
Alzheimer's disease".
520:, which triggers the heat shock response. The available evidence indicates that celastrol bonds covalently to the thiol groups of cysteine residues in its molecular targets.
1268:
Lee JH, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K, Lee JJ (2006). "Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid".
465:, anti-inflammatory, anticancer, and insecticidal activities. It has been shown to have obesity-controlling effects in mice by inhibiting negative regulators of
997:"Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo"
297:
532:
262:
854:"Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses"
75:)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
905:"Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin"
387:
205:
1411:"In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates"
226:
1415:
1374:
Salminen A, Lehtonen M, Paimela T, Kaarniranta K (April 2010). "Celastrol: Molecular targets of
Thunder God Vine".
1459:
717:"Antimicrobial Activity and Mode of Action of Celastrol, a Nortriterpen Quinone Isolated from Natural Sources"
1178:
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, et al. (November 2018).
956:"Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90"
168:
1469:
408:
536:
442:(IL-1). IL1R1 knock-out mice exposed to celastrol exhibit no leptin-sensitizing or anti-obesity effect.
46:
36:
1305:"Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice"
1464:
1316:
482:
427:
414:
1474:
903:
Metselaar DS, Meel MH, Benedict B, Waranecki P, Koster J, Kaspers GJL, Hulleman E (November 2019).
243:
96:
1114:
1070:
834:
791:
486:
1484:
1391:
1344:
1285:
1250:
1201:
1150:
1106:
1062:
1026:
977:
936:
885:
826:
783:
748:
697:
648:
597:
566:"SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii"
1434:
1424:
1383:
1334:
1324:
1277:
1240:
1232:
1191:
1142:
1098:
1054:
1016:
1008:
967:
926:
916:
875:
865:
818:
775:
738:
728:
687:
679:
638:
628:
617:"The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases"
587:
577:
320:
150:
214:
106:
1479:
1360:
1355:
423:
247:
172:
1359: This article incorporates text from this source, which is available under the
1320:
995:
Tiedemann RE, Schmidt J, Keats JJ, Shi CX, Zhu YX, Palmer SE, et al. (April 2009).
666:
Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, et al. (April 2019).
1489:
1439:
1410:
1339:
1304:
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1021:
996:
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904:
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592:
565:
381:
779:
1453:
838:
822:
528:
478:
458:
439:
369:
161:
40:
3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
1074:
795:
1118:
474:
419:
194:
1409:
Abdel-Halim MS, Askoura M, Mansour B, Yahya G, El-Ganiny AM (27 September 2022).
1329:
1180:"Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1"
1012:
921:
668:"IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects"
545:
462:
1429:
1387:
1236:
582:
1281:
683:
513:
348:
141:
564:
Ryu YB, Park SJ, Kim YM, Lee JY, Seo WD, Chang JS, et al. (March 2010).
1058:
870:
431:
1395:
1348:
1289:
1254:
1205:
1154:
1110:
1102:
1066:
1030:
981:
954:
Lee JH, Choi KJ, Seo WD, Jang SY, Kim M, Lee BW, et al. (March 2011).
940:
889:
830:
787:
752:
701:
652:
633:
601:
972:
955:
733:
493:
470:
447:
453:
181:
1303:
Kim JE, Lee MH, Nam DH, Song HK, Kang YS, Lee JE, et al. (2013).
1219:
Liu J, Lee J, Salazar
Hernandez MA, Mazitschek R, Ozcan U (May 2015).
1196:
1179:
1146:
23:
541:
505:
466:
380:
Except where otherwise noted, data are given for materials in their
509:
501:
435:
129:
119:
852:
Venkatesha SH, Yu H, Rajaiah R, Tong L, Moudgil KD (April 2011).
768:
Progress in Neuro-Psychopharmacology & Biological
Psychiatry
517:
497:
496:
signaling via multiple molecular targets: direct inhibition of
305:
CC1=C(C(=O)C=C2C1=CC=C32(CC4(3(CC5(4C(CC5)(C)C(=O)O)C)C)C)C)O
715:
Padilla-Montaño N, de León Guerra L, Moujir L (March 2021).
406:) is a chemical compound isolated from the root extracts of
231:
1047:
The
Journal of Pharmacology and Experimental Therapeutics
469:. Celastrol has also shown to possess (by inhibition of
418:(Regel's threewingnut). Celastrol is a pentacyclic
615:Zhang L, Wang Q, Liu W, Liu F, Ji A, Li Y (2018).
434:. Also in mice, celastrol increase expression of
430:agonist that alleviates inflammation and induces
193:
105:
8:
570:Bioorganic & Medicinal Chemistry Letters
960:International Journal of Molecular Medicine
1135:Journal of Agricultural and Food Chemistry
811:European Journal of Clinical Investigation
246:
171:
149:
15:
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1020:
971:
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879:
869:
742:
732:
691:
642:
632:
591:
581:
438:, which is the receptor for the cytokine
213:
556:
457:animal experiments, celastrol exhibits
302:
267:
242:
374:213 °C (415 °F; 486 K)
162:
1221:"Treatment of obesity with celastrol"
274:Key: KQJSQWZMSAGSHN-JJWQIEBTSA-N
7:
858:The Journal of Biological Chemistry
284:Key: KQJSQWZMSAGSHN-JJWQIEBTBS
184:
512:chaperone proteins, inhibition of
14:
1354:
1168:doi:10.1021/acs.jmedchem.8b01224
823:10.1111/j.1365-2362.2009.02186.x
523:Celastrol also has demonstrated
332:
22:
527:inhibitory effects against the
500:and β kinases, inactivation of
384:(at 25 °C , 100 kPa).
338:
326:
1:
780:10.1016/S0278-5846(01)00192-0
422:and belongs to the family of
1330:10.1371/journal.pone.0062068
1013:10.1182/blood-2008-09-179796
922:10.1016/j.ebiom.2019.10.062
516:function and activation of
426:. In mice, celastrol is an
1506:
1430:10.1038/s41429-022-00566-y
1416:The Journal of Antibiotics
1388:10.1016/j.bbrc.2010.03.050
1376:Biochem Biophys Res Commun
1237:10.1016/j.cell.2015.05.011
583:10.1016/j.bmcl.2010.01.152
1282:10.1016/j.bcp.2006.08.014
684:10.1038/s41591-019-0358-x
378:
313:
293:
258:
89:
81:
45:
35:
30:
21:
1270:Biochemical Pharmacology
1059:10.1124/jpet.110.165654
871:10.1074/jbc.M111.226365
485:and improve whole-body
412:(Thunder god vine) and
1103:10.1124/mol.109.056259
1091:Molecular Pharmacology
540:, in combination with
409:Tripterygium wilfordii
973:10.3892/ijmm.2011.601
734:10.3390/foods10030591
537:Klebsiella pneumoniae
47:Systematic IUPAC name
634:10.1155/2018/9363461
483:diabetic nephropathy
420:nortriterpen quinone
415:Tripterygium regelii
1321:2013PLoSO...862068K
492:Celastrol inhibits
356: g·mol
18:
487:insulin resistance
388:Infobox references
364:Crystalline solid
16:
1276:(10): 1311–1321.
1197:10.2337/db18-0146
1190:(11): 2456–2465.
1147:10.1021/jf990008w
396:Chemical compound
394:
393:
227:CompTox Dashboard
131:Interactive image
1497:
1460:Quinone methides
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951:
945:
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934:
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900:
894:
893:
883:
873:
864:(17): 15138–46.
849:
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799:
763:
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756:
746:
736:
712:
706:
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695:
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424:quinone methides
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321:Chemical formula
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1407:
1403:
1373:
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1368:
1302:
1301:
1297:
1267:
1266:
1262:
1231:(5): 999–1011.
1218:
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1177:
1176:
1172:
1166:
1162:
1131:
1130:
1126:
1087:
1086:
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1043:
1042:
1038:
1007:(17): 4027–37.
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948:
902:
901:
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851:
850:
846:
808:
807:
803:
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672:Nature Medicine
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1211:
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1124:
1080:
1036:
987:
946:
895:
844:
801:
774:(7): 1341–57.
758:
707:
678:(4): 575–582.
658:
621:J Diabetes Res
607:
555:
553:
550:
395:
392:
391:
386:
382:standard state
379:
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1470:Hydroxy acids
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1426:
1422:
1418:
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1397:
1393:
1389:
1385:
1382:(3): 439–42.
1381:
1377:
1370:
1367:
1364:
1362:
1357:
1350:
1346:
1341:
1336:
1331:
1326:
1322:
1318:
1315:(4): e62068.
1314:
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1144:
1140:
1136:
1128:
1125:
1120:
1116:
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1108:
1104:
1100:
1097:(4): 734–44.
1096:
1092:
1084:
1081:
1076:
1072:
1068:
1064:
1060:
1056:
1053:(2): 489–99.
1052:
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1037:
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1028:
1023:
1018:
1014:
1010:
1006:
1002:
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867:
863:
859:
855:
848:
845:
840:
836:
832:
828:
824:
820:
817:(9): 819–27.
816:
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777:
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769:
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589:
584:
579:
576:(6): 1873–6.
575:
571:
567:
560:
557:
551:
549:
547:
543:
539:
538:
534:
530:
529:carbapenemase
526:
521:
519:
515:
511:
507:
503:
499:
495:
490:
488:
484:
480:
479:anti-diabetic
476:
472:
468:
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459:antibacterial
456:
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449:
443:
441:
440:interleukin-1
437:
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389:
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370:Melting point
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244:DTXSID2040993
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163:ECHA InfoCard
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1224:
1214:
1187:
1183:
1173:
1163:
1141:(1): 88–92.
1138:
1134:
1127:
1094:
1090:
1083:
1050:
1046:
1039:
1004:
1000:
990:
966:(3): 441–6.
963:
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912:
909:EBioMedicine
908:
898:
861:
857:
847:
814:
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804:
771:
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573:
569:
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524:
522:
508:, which are
491:
475:hypothalamus
452:
446:
444:
413:
407:
403:
399:
398:
90:Identifiers
82:Other names
72:
68:
64:
60:
56:
52:
1465:Triterpenes
1423:: 679–690.
627:: 9363461.
546:monoterpene
481:effects on
463:antioxidant
361:Appearance
314:Properties
169:100.164.266
1475:Keto acids
1454:Categories
727:(3): 591.
552:References
514:proteasome
404:tripterine
349:Molar mass
215:L8GG98663L
142:ChemSpider
118:3D model (
107:34157-83-0
97:CAS Number
84:Tripterine
37:IUPAC name
17:Celastrol
1361:CC BY 4.0
915:: 81–92.
839:205291261
494:IKK-NF-κB
432:autophagy
400:Celastrol
1485:Polyenes
1396:20226165
1363:license.
1349:23637966
1309:PLOS ONE
1290:16984800
1255:26000480
1206:30158241
1184:Diabetes
1155:10637057
1111:19574249
1075:25854329
1067:20472666
1031:19096011
982:21249311
941:31735550
890:21402700
831:19549173
796:21569585
788:11513350
753:33799720
702:30833749
653:30013988
602:20167482
525:in vitro
448:in vitro
1440:9640353
1340:3637455
1317:Bibcode
1246:4768733
1119:6541041
1022:3952546
932:6921187
881:3083183
744:7998816
693:7158951
644:6022324
593:7127101
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