Knowledge

Centpropazine

Source ๐Ÿ“

29: 597: 255: 269: 602: 562: 476: 289: 297:
InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3
71: 153: 617: 355: 500:
shrafuzzaman M, Ji SH, Ahn H, Chung HW, Choi D, Park JJ, Go M, Pyo JI, Shafioul AS, Lee DH, Chi SG (29 March 2023).
607: 331: 592: 49: 502:"Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors" 612: 182: 362: 351: 88: 56: 568: 558: 523: 482: 472: 436: 324: 550: 513: 464: 426: 198: 142: 162: 97: 358: 327: 554: 468: 586: 387: 122: 347: 541:
Singh H, Chawla AS, Kapoor VK (1985). "Medicinal chemistry research in India".
361:
prior to the discontinuation of its development. It was first described in the
339: 231: 133: 20: 527: 486: 431: 414: 343: 440: 28: 572: 518: 501: 108: 173: 335: 254: 245: 459:
Kaiser C, Bondinell WE (1981). "Chapter 1. Antidepressants".
454: 452: 450: 243: 230: 197: 192: 172: 152: 132: 107: 87: 62: 48: 40: 35: 394:. Springer Nature Switzerland AG. 10 December 2013 338:but was never marketed. It is described as having 413:Avasthi A, Grover S, Aggarwal M (January 2010). 277:CCC(=O)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O 121: 96: 354:of centpropazine is unknown. The drug reached 346:-induced effects in animals, and potentiating 330:which was under development for the treatment 382: 380: 378: 8: 19: 141: 27: 517: 430: 161: 463:. Vol. 16. Elsevier. p. 1โ€“10. 598:Drugs with unknown mechanisms of action 506:Bulletin of the Korean Chemical Society 374: 294: 274: 76: 415:"Research on antidepressants in India" 18: 461:Annual Reports in Medicinal Chemistry 181: 7: 112: 342:-like clinical effects, reversing 14: 350:-induced effects in animals. The 215: 209: 543:Progress in Medicinal Chemistry 302:Key:ZQPXSRTZFYHSFB-UHFFFAOYSA-N 221: 203: 1: 555:10.1016/s0079-6468(08)70232-7 469:10.1016/s0065-7743(08)61268-3 603:Experimental antidepressants 419:Indian Journal of Psychiatry 16:Experimental antidepressant 634: 193:Chemical and physical data 332:major depressive disorder 285: 265: 67: 26: 432:10.4103/0019-5545.69263 425:(Suppl 1): S341โ€“S354. 512:(7). Wiley: 596โ€“599. 363:scientific literature 79:1-phenyl]propan-1-one 352:mechanism of action 23: 618:Secondary alcohols 519:10.1002/bkcs.12693 608:Phenylpiperazines 564:978-0-444-80668-0 478:978-0-12-040516-9 310: 309: 256:Interactive image 625: 577: 576: 538: 532: 531: 521: 497: 491: 490: 456: 445: 444: 434: 410: 404: 403: 401: 399: 384: 258: 238: 223: 217: 211: 205: 185: 165: 145: 125: 115: 114: 100: 31: 24: 22: 633: 632: 628: 627: 626: 624: 623: 622: 593:Abandoned drugs 583: 582: 581: 580: 565: 540: 539: 535: 499: 498: 494: 479: 458: 457: 448: 412: 411: 407: 397: 395: 388:"Centpropazine" 386: 385: 376: 371: 359:clinical trials 306: 303: 298: 293: 292: 281: 278: 273: 272: 261: 236: 226: 220: 214: 208: 188: 168: 148: 128: 111: 103: 83: 80: 75: 74: 51: 17: 12: 11: 5: 631: 629: 621: 620: 615: 610: 605: 600: 595: 585: 584: 579: 578: 563: 533: 492: 477: 446: 405: 373: 372: 370: 367: 328:antidepressant 308: 307: 305: 304: 301: 299: 296: 288: 287: 286: 283: 282: 280: 279: 276: 268: 267: 266: 263: 262: 260: 259: 251: 249: 241: 240: 234: 228: 227: 224: 218: 212: 206: 201: 195: 194: 190: 189: 187: 186: 178: 176: 170: 169: 167: 166: 158: 156: 150: 149: 147: 146: 138: 136: 130: 129: 127: 126: 118: 116: 105: 104: 102: 101: 93: 91: 85: 84: 82: 81: 78: 70: 69: 68: 65: 64: 60: 59: 54: 52:administration 46: 45: 42: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 630: 619: 616: 614: 613:Benzaldehydes 611: 609: 606: 604: 601: 599: 596: 594: 591: 590: 588: 574: 570: 566: 560: 556: 552: 548: 544: 537: 534: 529: 525: 520: 515: 511: 507: 503: 496: 493: 488: 484: 480: 474: 470: 466: 462: 455: 453: 451: 447: 442: 438: 433: 428: 424: 420: 416: 409: 406: 393: 389: 383: 381: 379: 375: 368: 366: 364: 360: 357: 353: 349: 345: 341: 337: 333: 329: 326: 322: 318: 314: 313:Centpropazine 300: 295: 291: 284: 275: 271: 264: 257: 253: 252: 250: 247: 242: 235: 233: 229: 202: 200: 196: 191: 184: 183:ChEMBL4303166 180: 179: 177: 175: 171: 164: 160: 159: 157: 155: 151: 144: 140: 139: 137: 135: 131: 124: 120: 119: 117: 110: 106: 99: 95: 94: 92: 90: 86: 77: 73: 66: 61: 58: 55: 53: 47: 43: 39: 36:Clinical data 34: 30: 25: 21:Centpropazine 546: 542: 536: 509: 505: 495: 460: 422: 418: 408: 398:27 September 396:. Retrieved 391: 325:experimental 320: 316: 312: 311: 549:: 243โ€“266. 392:AdisInsight 348:amphetamine 239: gยทmol 63:Identifiers 41:Other names 587:Categories 369:References 340:imipramine 244:3D model ( 232:Molar mass 163:R5YPG9LA47 134:ChemSpider 98:91315-34-3 89:CAS Number 72:IUPAC name 528:1229-5949 487:0065-7743 365:by 1980. 344:reserpine 50:Routes of 441:21836704 323:) is an 44:CPZ; CTZ 573:2873624 356:phase 3 237:368.477 199:Formula 109:PubChem 571:  561:  526:  485:  475:  439:  270:SMILES 174:ChEMBL 143:105612 123:118176 336:India 290:InChI 246:JSmol 569:PMID 559:ISBN 524:ISSN 483:ISSN 473:ISBN 437:PMID 400:2024 154:UNII 57:Oral 551:doi 514:doi 465:doi 427:doi 334:in 321:CTZ 317:CPZ 113:CID 589:: 567:. 557:. 547:22 545:. 522:. 510:44 508:. 504:. 481:. 471:. 449:^ 435:. 423:52 421:. 417:. 390:. 377:^ 319:, 213:28 207:22 575:. 553:: 530:. 516:: 489:. 467:: 443:. 429:: 402:. 315:( 248:) 225:3 222:O 219:2 216:N 210:H 204:C

Index


Routes of
administration

Oral
IUPAC name
CAS Number
91315-34-3
PubChem
118176
ChemSpider
105612
UNII
R5YPG9LA47
ChEMBL
ChEMBL4303166
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
experimental
antidepressant
major depressive disorder
India
imipramine
reserpine
amphetamine
mechanism of action
phase 3
clinical trials

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