118:
143:
351:
149:
917:
it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.
1554:
916:
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where
1184:
Paoletti A, Moudjou M, Paintrand M, et al. (1997). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles".
1242:
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro".
156:
1460:
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET".
624:
79:
605:
1628:
1599:
1213:
LeDizet M, Beck JC, Finkbeiner WE (1999). "Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells".
973:
955:
1623:
1618:
1431:
Cox JA, Tirone F, Durussel I, et al. (2005). "Calcium and magnesium binding to human centrin 3 and interaction with target peptides".
1497:
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".
1071:
838:
1053:
942:
1077:
142:
117:
938:
1273:"Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication"
59:
1151:"Characterization of green alga, yeast, and human centrins. Specific subdomain features determine functional diversity"
155:
148:
1592:
67:
1390:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
993:"Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene"
650:
1585:
1319:
1111:
1004:
131:
46:
1083:
796:
792:
745:
741:
1532:
1485:
1137:
91:
1308:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
821:
800:
766:
737:
1524:
1477:
1448:
1419:
1376:
1347:
1294:
1259:
1230:
1201:
1172:
1129:
1032:
39:
1569:
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1506:
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1409:
1401:
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87:
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1008:
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1307:
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1612:
1473:
1226:
1027:
992:
379:
1489:
1141:
71:
1565:
1536:
228:
108:
95:
978:
National Center for
Biotechnology Information, U.S. National Library of Medicine
960:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1510:
1124:
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125:
75:
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83:
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1263:
1255:
1133:
1234:
1205:
1176:
1036:
883:
878:
867:
712:
693:
1405:
1054:"Entrez Gene: CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast)"
910:
899:
679:
636:
1444:
1359:
Schiebel E, Bornens M (2004). "In search of a function for centrins".
851:
591:
1553:
554:
550:
1561:
906:
63:
359:
1100:"Centrosomes: Sfi1p and centrin unravel a structural riddle"
991:
Middendorp S, Paoletti A, Schiebel E, Bornens M (Sep 1997).
1306:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
218:
1573:
1388:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
340:
1271:
Lutz W, Lingle WL, McCormick D, et al. (2001).
814:
785:
759:
730:
1149:Wiech H, Geier BM, Paschke T, et al. (1996).
934:
932:
930:
165:
16:Protein-coding gene in the species Homo sapiens
1593:
8:
939:GRCh38: Ensembl release 89: ENSG00000153140
459:nucleotide-excision repair factor 2 complex
1600:
1586:
565:
375:
206:
103:
1518:
1413:
1341:
1331:
1288:
1166:
1123:
1026:
1016:
1048:
1046:
926:
20:
530:mitotic spindle pole body duplication
170:
129:
124:
7:
1550:
1548:
1572:. You can help Knowledge (XXG) by
811:
782:
756:
727:
703:
684:
660:
641:
615:
596:
345:
306:
244:
223:
14:
902:that in humans is encoded by the
1552:
1474:10.1111/j.1600-0854.2005.00312.x
1227:10.1152/ajplung.1998.275.6.L1145
464:half bridge of spindle pole body
349:
154:
147:
141:
116:
1520:11858/00-001M-0000-0010-8592-0
469:transcription export complex 2
360:More reference expression data
329:More reference expression data
1:
1629:Human chromosome 5 gene stubs
1373:10.1016/S0962-8924(00)88999-0
525:spindle pole body duplication
429:microtubule organizing center
139:
1312:Proc. Natl. Acad. Sci. U.S.A
1624:EF-hand-containing proteins
1619:Genes on human chromosome 5
474:nuclear pore nuclear basket
1645:
1547:
1511:10.1016/j.cell.2005.08.029
1082:gene details page in the
520:calcium-mediated signaling
1125:10.1016/j.cub.2003.12.019
974:"Mouse PubMed Reference:"
956:"Human PubMed Reference:"
882:
877:
873:
866:
850:
833:
818:
789:
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763:
734:
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691:
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648:
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635:
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603:
599:
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568:
564:
548:
378:
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357:
348:
339:
326:
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276:bronchial epithelial cell
256:
247:
217:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1168:10.1074/jbc.271.37.22453
997:Proc Natl Acad Sci U S A
50:, CDC31, CEN3, centrin 3
1198:10.1242/jcs.109.13.3089
1018:10.1073/pnas.94.17.9141
839:Chr 5: 90.39 – 90.41 Mb
1333:10.1073/pnas.242603899
1290:10.1074/jbc.M101324200
1256:10.1242/jcs.113.8.1355
515:microtubule nucleation
1098:Salisbury JL (2004).
280:palpebral conjunctiva
1221:(6 Pt 1): L1145–56.
1076:genome location and
913:family of proteins.
909:. It belongs to the
132:Chromosome 5 (human)
1324:2002PNAS...9916899M
1116:2004CBio...14..R27S
1084:UCSC Genome Browser
1009:1997PNAS...94.9141M
408:microtubule binding
393:calcium ion binding
284:germinal epithelium
1560:This article on a
1406:10.1101/gr.2596504
493:Biological process
417:Cellular component
386:Molecular function
1581:
1580:
1445:10.1021/bi048294e
1318:(26): 16899–903.
893:
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752:
719:
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631:
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535:protein transport
403:metal ion binding
370:
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334:
322:
321:
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201:
200:
96:CETN3 - orthologs
1636:
1602:
1595:
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1522:
1493:
1456:
1427:
1417:
1384:
1361:Trends Cell Biol
1355:
1345:
1335:
1302:
1292:
1283:(23): 20774–80.
1267:
1238:
1209:
1192:(13): 3089–102.
1180:
1170:
1161:(37): 22453–61.
1145:
1127:
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1057:
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1041:
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1030:
1020:
988:
982:
981:
970:
964:
963:
952:
946:
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874:
846:
841:
824:
812:
803:
783:
779:RefSeq (protein)
769:
757:
748:
728:
704:
685:
661:
642:
616:
597:
566:
505:centrosome cycle
479:nuclear envelope
376:
362:
353:
346:
331:
307:
288:ventricular zone
272:secondary oocyte
252:
250:Top expressed in
245:
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1430:
1400:(10B): 2121–7.
1387:
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1091:Further reading
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884:View/Edit Mouse
879:View/Edit Human
844:
837:
834:Location (UCSC)
820:
799:
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736:
651:ENSG00000153140
544:
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398:protein binding
358:
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292:Achilles tendon
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107:Gene location (
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1428:
1385:
1367:(5): 197–201.
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1268:
1250:(8): 1355–64.
1239:
1215:Am. J. Physiol
1210:
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1065:External links
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1003:(17): 9141–6.
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540:mRNA transport
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211:RNA expression
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1505:(6): 957–68.
1504:
1500:
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1471:
1468:(9): 741–55.
1467:
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1442:
1439:(3): 840–50.
1438:
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1277:J. Biol. Chem
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1155:J. Biol. Chem
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770:
768:
762:
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755:
749:
747:
743:
739:
733:
729:
726:
724:RefSeq (mRNA)
722:
715:
714:
709:
705:
702:
696:
695:
690:
686:
683:
681:
677:
670:
666:
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541:
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531:
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510:cell division
508:
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475:
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380:Gene ontology
377:
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312:
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305:
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81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
1574:expanding it
1566:chromosome 5
1559:
1544:
1502:
1498:
1465:
1461:
1436:
1433:Biochemistry
1432:
1397:
1393:
1364:
1360:
1315:
1311:
1280:
1276:
1247:
1243:
1218:
1214:
1189:
1185:
1158:
1154:
1110:(1): R27–9.
1107:
1103:
1078:
1072:
1000:
996:
986:
977:
968:
959:
950:
915:
903:
895:
894:
819:
797:NP_001284697
793:NP_001284694
790:
764:
746:NM_001297768
742:NM_001297765
735:
711:
692:
668:
649:
623:
604:
584:
579:
484:nuclear pore
449:cytoskeleton
268:right testis
234:
227:
55:External IDs
18:
1244:J. Cell Sci
1186:J. Cell Sci
264:left testis
193:90,409,766
180:90,392,257
33:Identifiers
1613:Categories
1394:Genome Res
1104:Curr. Biol
945:, May 2017
921:References
500:cell cycle
439:centrosome
238:(ortholog)
76:HomoloGene
1564:on human
896:Centrin-3
822:NP_031710
801:NP_004356
767:NM_007684
738:NM_004365
570:Orthologs
444:nucleolus
434:centriole
424:cytoplasm
84:GeneCards
1529:16169070
1490:36574274
1482:16101678
1453:15654740
1424:15489334
1381:14731449
1352:12477932
1299:11279195
1264:10725219
1142:16717091
1134:14711432
941:–
868:Wikidata
549:Sources:
1537:8235923
1462:Traffic
1320:Bibcode
1235:9843852
1206:9004043
1177:8798410
1112:Bibcode
1037:9256449
1005:Bibcode
943:Ensembl
911:centrin
900:protein
680:UniProt
637:Ensembl
576:Species
555:QuickGO
454:nucleus
213:pattern
72:1097706
40:Aliases
1535:
1527:
1488:
1480:
1451:
1422:
1415:528928
1412:
1379:
1350:
1343:139241
1340:
1297:
1262:
1233:
1204:
1175:
1140:
1132:
1070:Human
1035:
1025:
854:search
852:PubMed
713:O35648
694:O15182
592:Entrez
341:BioGPS
260:oocyte
172:5q14.3
64:602907
1568:is a
1533:S2CID
1486:S2CID
1138:S2CID
1079:CETN3
1073:CETN3
1028:23077
904:CETN3
898:is a
625:12626
585:Mouse
580:Human
551:Amigo
296:sperm
236:Mouse
229:Human
176:Start
109:Human
88:CETN3
80:74521
47:CETN3
24:CETN3
1570:stub
1562:gene
1525:PMID
1499:Cell
1478:PMID
1449:PMID
1420:PMID
1377:PMID
1348:PMID
1295:PMID
1260:PMID
1231:PMID
1202:PMID
1173:PMID
1130:PMID
1033:PMID
907:gene
606:1070
219:Bgee
167:Band
126:Chr.
60:OMIM
1515:hdl
1507:doi
1503:122
1470:doi
1441:doi
1410:PMC
1402:doi
1369:doi
1338:PMC
1328:doi
1285:doi
1281:276
1252:doi
1248:113
1223:doi
1219:275
1194:doi
1190:109
1163:doi
1159:271
1120:doi
1023:PMC
1013:doi
845:n/a
669:n/a
316:n/a
189:End
92:OMA
68:MGI
1615::
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1447:.
1437:44
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1001:94
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929:^
553:/
195:bp
182:bp
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1594:t
1587:v
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