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Cerebral hypoxia

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If hypoxia results in coma, the length of unconsciousness is often indicative of long-term damage. In some cases coma can give the brain an opportunity to heal and regenerate, but, in general, the longer a coma, the greater the likelihood that the person will remain in a vegetative state until death.
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applied within 6 hours of cerebral hypoxia effectively improves survival and neurological outcome. In adults, however, the evidence is less convincing and the first goal of treatment is to restore oxygen to the brain. The method of restoration depends on the cause of the hypoxia. For mild-to-moderate
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Cerebral hypoxia refers to oxygen levels in brain tissue, not blood. Blood oxygenation will usually appear normal in cases of hypemic, ischemic, and hystoxic cerebral hypoxia. Even in hypoxic hypoxia blood measures are only an approximate guide; the oxygen level in the brain tissue will depend on
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per minute. Initially the body responds to lowered blood oxygen by redirecting blood to the brain and increasing cerebral blood flow. Blood flow may increase up to twice the normal flow but no more. If the increased blood flow is sufficient to supply the brain's oxygen needs then no symptoms will
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and places the patient at increased risk for a major stroke in the future. In a broad study in 1998, more than 11 million people were estimated to have experienced a stroke in the United States. Approximately 770,000 of these strokes were symptomatic and 11 million were first-ever silent MRI
609:– Limited oxygen in the environment causes reduced brain function. Divers, aviators, mountain climbers, and fire fighters are all at risk for this kind of cerebral hypoxia. The term also includes oxygen deprivation due to obstructions in the lungs. Choking, strangulation, the crushing of the 216:
Cerebral hypoxia can be caused by any event that severely interferes with the brain's ability to receive or process oxygen. This event may be internal or external to the body. Mild and moderate forms of cerebral hypoxia may be caused by various diseases that interfere with breathing and
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of the brain (left side) typically causes problems with speech and language. Damage to the right side of the brain may interfere with the ability to express emotions or interpret what one sees. Damage on either side can cause paralysis of the opposite side of the body.
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are termed "anoxia", which can be hypoxic in origin (reduced oxygen availability) or ischemic in origin (oxygen deprivation due to a disruption in blood flow). Brain injury as a result of oxygen deprivation either due to hypoxic or anoxic mechanisms are generally termed
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Mild and moderate cerebral hypoxia may result in seizures and impaired memory going forward. The outcome of severe cerebral hypoxia will depend on the success of damage control, amount of brain tissue deprived of oxygen, and the speed with which oxygen was restored.
404:. Sometimes, even an infant that is still in the womb may exhibit signs of HIE or other hypoxic ischemic injury. Fetal distress being one of the most common signs of HIE or other oxygen-depriving event. Other problems during pregnancy may include 834:
Long-term comas can have a significant impact on a patient's family. Families of coma patients often have idealized images of the outcome based on Hollywood movie depictions of coma. Adjusting to the realities of ventilators, feeding tubes,
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in the mother. Problems after delivery can include severe prematurity, severe lung or heart disease, serious infections, trauma to the brain or skull, congenital malformations of the brain or very low blood pressure in the baby and due to
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However, if blood flow cannot be increased or if doubled blood flow does not correct the problem, symptoms of cerebral hypoxia will begin to appear. Mild symptoms include difficulties with complex learning tasks and reductions in
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There has long been a debate over whether newborn infants with cerebral hypoxia should be resuscitated with 100% oxygen or normal air. It has been demonstrated that high concentrations of oxygen lead to generation of oxygen
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cases of hypoxia, removal of the cause of hypoxia may be sufficient. Inhaled oxygen may also be provided. In severe cases treatment may also involve life support and damage control measures.
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In severe cases it is extremely important to act quickly. Brain cells are very sensitive to reduced oxygen levels. Once deprived of oxygen they will begin to die off within five minutes.
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which does not have any outward symptoms, and the patient is typically unaware they have had a stroke. Despite its lack of identifiable symptoms, a silent stroke still causes
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Konig P, et al. (1992). "Psychological counseling of the family of patients with craniocerebral injuries (psychological family counseling of severely ill patients)"".
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Davis, PG; Tan, A; O'Donnell, CPF; Schulze, A (2004). "Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis".
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Brain damage can occur both during and after oxygen deprivation. During oxygen deprivation, cells die due to an increasing acidity in the brain tissue (
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levels, and hemodilution (thinning of the blood) coupled with drug-induced hypertension are some treatment techniques currently under investigation.
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paralysis (opposite side of body from affected brain hemisphere), or sudden weakness or numbness. A TIA may cause sudden dimming or loss of vision,
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Robinson, LR; Micklesen, PJ; Tirschwell, DL; Lew, HL (Mar 2003). "Predictive value of somatosensory evoked potentials for awakening from coma".
373:. The risk of silent stroke increases with age but may also affect younger adults. Women appear to be at increased risk for silent stroke, with 3063: 2736: 795:
If cerebral hypoxia was localized to a specific part of the brain, brain damage will be localized to that region. A general consequence may be
558:– A stroke occurring in a localized area that can either be acute or transient. This may be due to a variety of medical conditions such as an 3549: 3088: 2720: 1642: 316:(AHA/ASA) refined the definition of transient ischemic attack. TIA is now defined as a transient episode of neurologic dysfunction caused by 1599:
Pressman B. D.; Tourje E. J.; Thompson J. R. (Sep 1987). "An early CT sign of ischemic infarction: increased density in a cerebral artery".
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and others led to new international guidelines on newborn resuscitation in 2010, recommending the use of normal air instead of 100% oxygen.
3554: 2926: 2914: 2376: 100:. There are four categories of cerebral hypoxia; they are, in order of increasing severity: diffuse cerebral hypoxia (DCH), focal cerebral 1654: 3145: 3078: 2633: 520: 514: 242: 811:
The effects of certain kinds of severe generalized hypoxias may take time to develop. For example, the long-term effects of serious
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Cerebral hypoxia is typically grouped into four categories depending on the severity and location of the brain's oxygen deprivation:
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A deep coma will interfere with the body's breathing reflexes even after the initial cause of hypoxia has been dealt with;
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Even if the patient wakes up, brain damage is likely to be significant enough to prevent a return to normal functioning.
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Leary M. C.; Saver J. L. (2003). "Annual incidence of first silent stroke in the United States: a preliminary estimate".
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Ferro J. M.; et al. (Dec 1996). "Diagnosis of transient ischemic attack by the nonneurologist: A validation study".
3772: 3397: 3130: 2504: 1154: 623:– Reduced brain function is caused by inadequate oxygen in the blood despite adequate environmental oxygen. Anemia and 200:
Objective measurements of the severity of cerebral hypoxia depend on the cause. Blood oxygen saturation may be used for
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Gardiner M, Eisen S, Murphy C. Training in paediatrics: the essential curriculum. Oxford University Press, Oxford 2009.
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Geraghty M. C.; Torbey M. T. (2006). "Neuroimaging and serologic markers of neurologic injury after cardiac arrest".
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Jacobs, Susan E; Berg, Marie; Hunt, Rod; Tarnow-Mordi, William O; Inder, Terrie E; Davis, Peter G (2013-01-31).
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build up. When oxygen enters the tissue these materials interact with oxygen to create high levels of oxidants.
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Details of the mechanism of damage from cerebral hypoxia, along with anoxic depolarization, can be found here:
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may be difficult. Treatment decisions often involve complex ethical choices and can strain family dynamics.
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This website provides hypoxia related safety tips for aviators working for the United States Navy aviators.
328:. The symptoms of a TIA can resolve within a few minutes, unlike a stroke. TIAs share the same underlying 3925: 3908: 3903: 3893: 3734: 3670: 3312: 3213: 3005: 2997: 2952: 2628: 2600: 2448: 777: 691: 575: 73: 714:
may all be tried in an effort to get the heart to resume pumping. Severe cerebral hypoxia can also cause
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as strokes; a disruption of cerebral blood flow. TIAs and strokes present with the same symptoms such as
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Wijdicks E. F. M.; Wijdicks C. A. (2006). "The portrayal of coma in contemporary motion pictures".
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poisoning usually may take several weeks to appear. Recent research suggests this may be due to an
735: 650: 593: 588: 325: 296: 288: 238: 105: 633:( or "stagnant hypoxia") – Reduced brain oxygen is caused by inadequate blood flow to the brain. 3834: 3744: 3326: 3056: 3041: 3029: 2779: 2730: 2567: 2430: 2318: 2080: 1984: 1843: 1815: 1686: 1377: 1006: 922: 758: 731: 665: 610: 563: 284: 280: 230: 141: 2252: 804: 2125:
Montgomery V, et al. (2002). "The effect of severe traumatic brain injury on the family".
1658: 799:. The long-term effects will depend on the purpose of that portion of the brain. Damage to the 3983: 3625: 3574: 3474: 2819: 2785: 2757: 2748: 2680: 2656: 2523: 2371: 2233: 2142: 2107: 2072: 1941: 1862: 1807: 1770: 1752: 1638: 1616: 1549: 1459: 1418: 1369: 1334: 1293: 1252: 1144: 1119: 1082: 1041: 998: 963: 914: 852: 670: 397: 378: 174: 85: 68: 3630: 3279: 2942: 2813: 2808: 2593: 2588: 2134: 2064: 2031: 1852: 1799: 1760: 1744: 1664: 1608: 1539: 1449: 1408: 1361: 1324: 1283: 1244: 1194:. Maryland Institute for Emergency Medical Services Systems (2004). Retrieved on 2007-04-13. 1072: 1033: 990: 953: 906: 645:
may cause stagnant hypoxia. Ischemic hypoxia can also be created by pressure on the brain.
413: 272: 59: 745:). Additionally, during the period of oxygen deprivation, materials that can easily create 3988: 3822: 3817: 3729: 3452: 3407: 3287: 2864: 2555: 1915: 1717: 862: 812: 754: 719: 605: 201: 190: 800: 552:– A mild to moderate impairment of brain function due to low oxygen levels in the blood. 3871: 3721: 3584: 3544: 3479: 3440: 3351: 2921: 2870: 2698: 2407: 2284: 2068: 1765: 1544: 1527: 994: 942:"Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related" 867: 840: 836: 646: 638: 456: 424: 276: 249: 145: 2187: 1803: 3972: 3739: 3402: 2947: 2899: 2769: 2538: 2494: 2345: 2138: 2010: 1857: 1838: 910: 769: 746: 727: 703: 654: 344: 333: 292: 268: 2084: 2006: 1819: 1732: 1381: 1010: 926: 669:– Oxygen is present in brain tissue but cannot be metabolized by the brain tissue. 3880: 3792: 3607: 3297: 3240: 3182: 2443: 2313: 2296: 1748: 892: 857: 658: 642: 436: 405: 374: 366: 353: 165: 1903:
Richmond, T. S. (May 1997). "Cerebral Resuscitation after Global Brain Ischemia",
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levels showing a possible reduction in the overall systemic inflammatory process.
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Cerebral hypoxia can also be classified by the cause of the reduced brain oxygen:
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Techniques for preventing damage to brain cells are an area of ongoing research.
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Severe cerebral hypoxia and anoxia is usually caused by traumatic events such as
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The severity of a neonatal hypoxic-ischaemic brain injury may be assessed using
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Orozco-Gutierrez A, Rojas-Cerda L, Estrada RM, Gil-Rosales C (December 2010).
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For newborn infants starved of oxygen during birth there is now evidence that
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is the only evidence-supported therapy, but antioxidant drugs, control of
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may be required. Additionally, severe cerebral hypoxia causes an elevated
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Floppiness, or unreactive to sights or sounds, or more tense and agitated.
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The brain requires approximately 3.3 ml of oxygen per 100 g of
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can cause some degree of diffuse cerebral hypoxia. Other causes include
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Spinal muscular atrophy with lower extremity predominance (SMALED)
1657:. Gray Laboratory Cancer Research Trust. 1999-08-01. Archived from 1481:"What You Need To Know About Hypoxic Ischemic Encephalopathy (HIE)" 256:, and intense exercise at high altitudes prior to acclimatization. 3566: 2209: 1504: 537: 155: 208:
how the body deals with the reduced oxygen content of the blood.
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Hypoxic-anoxic events may affect the fetus at various stages of
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is being evaluated with the reduction in total and myocardial
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Basic Neurochemistry: Molecular, Cellular and Medical Aspects
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at the American Association of Critical-Care Nurses website.
1733:"Cooling for newborns with hypoxic ischaemic encephalopathy" 718:, which put the patient at risk of self-injury, and various 698:, and in extreme cases the heart may tire and stop pumping. 617:
exacerbations may also lead to symptoms of hypoxic hypoxia.
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response caused by carbon monoxide-induced changes in the
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Norwegian paediatrician honoured by University of Athens
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Weak breathing, no breathing at all, or rapid breathing.
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National Institute of Neurological Disorders and Stroke
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drugs may need to be administered before treatment.
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Low Apgar scores, <5 at 5 minutes and 10 minutes.
308:(TIA), is often referred to as a "mini-stroke". The 3944: 3879: 3870: 3805: 3765: 3720: 3624: 3606: 3597: 3565: 3525: 3430: 3390: 3367: 3278: 3269: 3239: 3221: 3019: 2996: 2987: 2980: 2935: 2885: 2857: 2828: 2794: 2756: 2745: 2711: 2689: 2614: 2424: 2415: 2401: 2361: 2304: 2295: 2219: 2164: 67: 44: 1948:. Archived from the original on September 6, 2013 584:– A complete stoppage of blood flow to the brain. 566:occurring in the affected blood vessels due to a 2007:"'Rewired brain' revives patient after 19 years" 291:. It is also recreationally self-induced in the 1581:The Gale Encyclopedia of Neurological Disorders 898:American Journal of Physiology. Cell Physiology 766:Hypothermia therapy for neonatal encephalopathy 684:hypothermia therapy for neonatal encephalopathy 423:Problems during labor and delivery can include 459:, which is based on clinical presentation and 3198: 2268: 8: 1879:ILCOR Neonatal Resuscitation Guidelines 2010 1635:Animal Models of Acute Neurological Injuries 757:and cause further damage (this is known as " 1899: 1897: 1713:"Cooling 'cure' averts infant brain damage" 3876: 3778:Chronic cerebrospinal venous insufficiency 3603: 3275: 3236: 3205: 3191: 3183: 2993: 2984: 2753: 2421: 2412: 2301: 2275: 2261: 2253: 2161: 596:which affects multiple areas of the brain. 439:, prolonged late stages of labor, or very 50: 41: 1856: 1764: 1543: 1453: 1412: 1328: 1287: 1076: 957: 940:Mattiesen W. R.; et al. (May 2009). 544:one cause of hypoxic anoxic injury (HAI). 467:. Signs and symptoms of HIE may include: 160:CT in a person after generalized hypoxia. 1173: 1171: 562:that causes a hemorrhagic stroke, or an 1737:Cochrane Database of Systematic Reviews 1436:HerderscheĂŞ D, et al. (Sep 1992). 1395:Vermeer S. E.; et al. (Jan 2002). 1311:HerderscheĂŞ D, et al. (Sep 1992). 1202: 1200: 883: 613:all cause this sort of hypoxia. Severe 400:, during labor and delivery and in the 116:, resulting in a hypoxic brain injury. 3064:Distal hereditary motor neuronopathies 2737:Template:Demyelinating diseases of CNS 1958: 661:and impede their absorption of oxygen. 489:Need for resuscitation after delivery. 3550:Hereditary hemorrhagic telangiectasia 1507:. Florida Neonatal Neurologic Network 1475: 1473: 627:are common causes of hypemic hypoxia. 483:Poor muscle tone and absent reflexes. 324:, or retinal ischemia, without acute 7: 3555:Generalized essential telangiectasia 2915:Idiopathic intracranial hypertension 1833:Kutzsche, S; Ilves, P; Kirkeby, OJ; 1711:Laurance, Jeremy (October 1, 2009). 1059:Busl K. M.; Greer D. M. (Jan 2010). 891:Malhotra R, et al. (Nov 2001). 1689:Naval Safety Center. Archived from 1633:Jun Chen, Zao C. Xu, Xiao-Ming Xu, 1270:Easton JD, et al. (Jun 2009). 1212:"Cerebral Hypoxia Information Page" 237:-rich environments, ascent from a 185:, long-term loss of consciousness, 3146:Infantile progressive bulbar palsy 2069:10.1212/01.wnl.0000210497.62202.e9 1677:Brooks, Kevin E. (May–June 2005). 995:10.1097/01.ccm.0000053643.21751.3b 521:anoxic depolarization in the brain 515:Anoxic depolarization in the brain 365:which are detected via the use of 25: 2849:Template:Cerebrovascular diseases 2652:Frontotemporal lobar degeneration 1116:Lippincott Williams & Wilkins 361:. Silent strokes typically cause 3705:Cerebral venous sinus thrombosis 2869:For more detailed coverage, see 2847:For more detailed coverage, see 2818:For more detailed coverage, see 2784:For more detailed coverage, see 2735:For more detailed coverage, see 2139:10.1097/00005373-200206000-00016 2030:Mayo Clinic staff (2006-05-17). 1907:8 (2). Retrieved on 2007-04-13. 1858:10.1203/00006450-200106000-00020 1150:MedlinePlus Medical Encyclopedia 911:10.1152/ajpcell.2001.281.5.c1596 191:cessation of brain stem reflexes 1102:Butterworth, Roger F. (1999). " 501:Seizures or abnormal movements. 134:Hypoxic ischemic encephalopathy 3656:Hepatic veno-occlusive disease 2005:Phillips, Helen (2006-07-03). 1934:Diving and Hyperbaric Medicine 1749:10.1002/14651858.cd003311.pub3 542:Aneurysm in a cerebral artery, 92:), specifically involving the 1: 3468:Aneurysm of sinus of Valsalva 3322:Monckeberg's arteriosclerosis 3162:Amyotrophic lateral sclerosis 3047:Hereditary spastic paraplegia 2905:Normal pressure hydrocephalus 1983:Medical Center (2004-09-06). 1804:10.1016/S0140-6736(04)17189-4 1663:Retrieved on 2007-04-13 from 1585:Retrieved on 2007-04-13 from 1216:National Institutes of Health 1114:, 6th edition, Philadelphia: 431:, rupture of the placenta or 3773:Chronic venous insufficiency 3398:Aortoiliac occlusive disease 3131:Progressive muscular atrophy 1583:. The Gale Group, Inc. 2005. 1289:10.1161/STROKEAHA.108.192218 1155:National Library of Medicine 734:after asphyxia. Research by 498:Excessive acid in the blood. 450:MĂĽnchausen syndrome by proxy 27:Oxygen shortage of the brain 3788:Inferior vena cava syndrome 3783:Superior vena cava syndrome 3510:Vertebral artery dissection 3500:Intracranial berry aneurysm 2641:Primary progressive aphasia 1914:September 27, 2007, at the 1679:"Are you a hypoxia expert?" 1637:, Humana Press; 1 edition, 381:being predisposing factors. 314:American Stroke Association 4005: 3889:Hypertensive heart disease 3540:Arteriovenous malformation 3515:Familial aortic dissection 2963:Hashimoto's encephalopathy 2669:Posterior cortical atrophy 2490:Striatonigral degeneration 2341:Cavernous sinus thrombosis 1981:University of Pennsylvania 1134:. Retrieved on 2007-04-13. 753:interfere with the normal 512: 495:Bluish or pale skin color. 389: 310:American Heart Association 29: 3914:Renovascular hypertension 3857:Hepatic artery thrombosis 3505:Carotid artery dissection 3458:Abdominal aortic aneurysm 3308:Intermittent claudication 3271:Peripheral artery disease 3069:Spinal muscular atrophies 3037:Primary lateral sclerosis 2895:Intracranial hypertension 2675:Creutzfeldt–Jakob disease 1965:: CS1 maint: unfit URL ( 1249:10.1161/01.STR.27.12.2225 1106:". In: Siegel, George J. 1038:10.1016/j.ncl.2005.10.006 959:10.1007/s00401-009-0509-0 774:Hyperbaric oxygen therapy 625:carbon monoxide poisoning 463:findings, and also using 305:Transient ischemic attack 58: 49: 3899:Hypertensive nephropathy 3712:Post-thrombotic syndrome 3693:Paget–Schroetter disease 3485:Coronary artery aneurysm 3463:Thoracic aortic aneurysm 3136:Progressive bulbar palsy 2927:Intracranial hypotension 2910:Choroid plexus papilloma 2324:Herpesviral encephalitis 1455:10.1161/01.str.23.9.1220 1330:10.1161/01.str.23.9.1220 673:is a well-known example. 582:Global cerebral ischemia 550:Diffuse cerebral hypoxia 3954:Orthostatic hypotension 3936:White coat hypertension 3413:Fibromuscular dysplasia 3377:Carotid artery stenosis 2648:Frontotemporal dementia 2334:Encephalitis lethargica 730:, which have a role in 570:(thrombotic stroke) or 556:Focal cerebral ischemia 392:Neonatal encephalopathy 126:hypoxic/anoxic injuries 3926:Pulmonary hypertension 3909:Secondary hypertension 3904:Essential hypertension 3894:Hypertensive emergency 3735:Portacaval anastomosis 3671:Portal vein thrombosis 3313:Critical limb ischemia 3214:Cardiovascular disease 2953:Hepatic encephalopathy 1104:Hypoxic Encephalopathy 983:Critical Care Medicine 778:creatine phosphokinase 692:mechanical ventilation 576:middle cerebral artery 545: 427:occlusion, torsion or 161: 74:Critical care medicine 63:Arteries beneath brain 3931:Systolic hypertension 3676:Renal vein thrombosis 3535:Arteriovenous fistula 3527:Vascular malformation 3495:Intracranial aneurysm 3382:Renal artery stenosis 3011:Ataxia–telangiectasia 2968:Static encephalopathy 2691:Mitochondrial disease 2529:Spasmodic torticollis 2439:Basal ganglia disease 2032:"Coma: Coping skills" 1613:10.2214/ajr.149.3.583 1532:Paediatr Child Health 1414:10.1161/hs0102.101629 1078:10.3233/NRE-2010-0531 541: 390:Further information: 225:and various sorts of 159: 3845:Paradoxical embolism 3840:Cholesterol embolism 3666:May–Thurner syndrome 3661:Budd–Chiari syndrome 3644:Deep vein thrombosis 3639:primarily lower limb 3418:Raynaud's phenomenon 2958:Toxic encephalopathy 2664:Lewy bodies dementia 1905:AACN Clinical Issues 1526:Bellemare S (2006). 30:For other uses, see 3921:Benign hypertension 3006:Friedreich's ataxia 2389:Meningoencephalitis 2329:Limbic encephalitis 2100:Zentralbl Neurochir 1798:(9442): 1329–1333. 1601:AJR Am J Roentgenol 1065:NeuroRehabilitation 823:sheath surrounding 736:Ola Didrik Saugstad 594:cerebral blood flow 589:Cerebral infarction 480:Low blood pressure. 297:erotic asphyxiation 254:supplemental oxygen 106:cerebral infarction 88:(reduced supply of 3835:Pulmonary embolism 3745:Esophageal varices 3683:upper limb / torso 3327:Arteriolosclerosis 3042:Pseudobulbar palsy 2780:Status epilepticus 2731:Multiple sclerosis 2568:Myoclonic epilepsy 2431:movement disorders 2377:Acute disseminated 2319:Viral encephalitis 2248:Hypoxia experiment 2220:External resources 1844:Pediatric Research 1687:United States Navy 1655:"What is Hypoxia?" 1485:Birth Injury Guide 1145:"Cerebral hypoxia" 905:(5): C1596–C1603. 759:reperfusion injury 732:reperfusion injury 666:Histotoxic hypoxia 657:exert pressure on 546: 441:low blood pressure 386:Pre- and postnatal 285:status asthmaticus 279:, crushing of the 231:status epilepticus 162: 152:Signs and symptoms 121:oxygen deprivation 3966: 3965: 3962: 3961: 3806:Arteries or veins 3801: 3800: 3626:Venous thrombosis 3593: 3592: 3575:Cherry hemangioma 3475:Aortic dissection 3426: 3425: 3261:Buerger's disease 3180: 3179: 3176: 3175: 3172: 3171: 2976: 2975: 2881: 2880: 2820:Template:Headache 2786:Template:Epilepsy 2707: 2706: 2681:Vascular dementia 2524:Status dystonicus 2397: 2396: 2372:Encephalomyelitis 2243: 2242: 2127:Journal of Trauma 1643:978-1-60327-184-4 1366:10.1159/000071128 1243:(12): 2225–2229. 853:Altitude sickness 671:Cyanide poisoning 651:brain hemorrhages 410:maternal diabetes 398:fetal development 379:cigarette smoking 219:blood oxygenation 175:short-term memory 79: 78: 39:Medical condition 16:(Redirected from 3996: 3877: 3688:Mondor's disease 3631:Thrombophlebitis 3604: 3280:Arteriosclerosis 3276: 3237: 3207: 3200: 3193: 3184: 2994: 2985: 2943:Brain herniation 2754: 2594:Intention tremor 2589:Essential tremor 2454:Postencephalitic 2422: 2413: 2302: 2283:Diseases of the 2277: 2270: 2263: 2254: 2162: 2151: 2150: 2133:(6): 1121–1124. 2122: 2116: 2115: 2095: 2089: 2088: 2063:(9): 1300–1303. 2052: 2046: 2045: 2043: 2042: 2027: 2021: 2020: 2018: 2017: 2002: 1996: 1995: 1993: 1992: 1977: 1971: 1970: 1964: 1956: 1954: 1953: 1925: 1919: 1901: 1892: 1886: 1880: 1877: 1871: 1870: 1860: 1830: 1824: 1823: 1785: 1779: 1778: 1768: 1728: 1722: 1709: 1703: 1701: 1699: 1698: 1674: 1668: 1662: 1651: 1645: 1631: 1625: 1624: 1596: 1590: 1584: 1573: 1567: 1564: 1558: 1557: 1547: 1523: 1517: 1516: 1514: 1512: 1501: 1495: 1494: 1492: 1491: 1477: 1468: 1467: 1457: 1448:(9): 1220–1224. 1433: 1427: 1426: 1416: 1392: 1386: 1385: 1349: 1343: 1342: 1332: 1323:(9): 1220–1224. 1308: 1302: 1301: 1291: 1282:(6): 2276–2293. 1267: 1261: 1260: 1232: 1226: 1225: 1223: 1222: 1204: 1195: 1193: 1185: 1183: 1175: 1166: 1165: 1163: 1162: 1141: 1135: 1128:Freely available 1100: 1091: 1090: 1080: 1056: 1050: 1049: 1021: 1015: 1014: 978: 972: 971: 961: 946:Acta Neuropathol 937: 931: 930: 888: 631:Ischemic hypoxia 504:Problems feeding 414:vascular disease 402:postnatal period 273:smoke inhalation 82:Cerebral hypoxia 60:Circle of Willis 54: 45:Cerebral hypoxia 42: 21: 4004: 4003: 3999: 3998: 3997: 3995: 3994: 3993: 3979:Brain disorders 3969: 3968: 3967: 3958: 3940: 3866: 3823:Microangiopathy 3818:Macroangiopathy 3797: 3761: 3730:Gastric varices 3716: 3629: 3620: 3589: 3561: 3521: 3453:Aortic aneurysm 3439: 3422: 3408:Erythromelalgia 3386: 3363: 3288:Atherosclerosis 3265: 3229: 3217: 3211: 3181: 3168: 3094:Congenital DSMA 3015: 2972: 2931: 2877: 2865:Sleep disorders 2853: 2830:Cerebrovascular 2824: 2790: 2747: 2741: 2703: 2685: 2610: 2556:Choreoathetosis 2429: 2406: 2393: 2357: 2291: 2281: 2244: 2239: 2238: 2215: 2214: 2173: 2159: 2154: 2124: 2123: 2119: 2097: 2096: 2092: 2054: 2053: 2049: 2040: 2038: 2029: 2028: 2024: 2015: 2013: 2004: 2003: 1999: 1990: 1988: 1979: 1978: 1974: 1957: 1951: 1949: 1927: 1926: 1922: 1916:Wayback Machine 1902: 1895: 1887: 1883: 1878: 1874: 1832: 1831: 1827: 1787: 1786: 1782: 1743:(1): CD003311. 1730: 1729: 1725: 1718:The Independent 1710: 1706: 1696: 1694: 1676: 1675: 1671: 1653: 1652: 1648: 1632: 1628: 1598: 1597: 1593: 1575: 1574: 1570: 1565: 1561: 1525: 1524: 1520: 1510: 1508: 1503: 1502: 1498: 1489: 1487: 1479: 1478: 1471: 1435: 1434: 1430: 1394: 1393: 1389: 1354:Cerebrovasc Dis 1351: 1350: 1346: 1310: 1309: 1305: 1269: 1268: 1264: 1234: 1233: 1229: 1220: 1218: 1206: 1205: 1198: 1187: 1181: 1177: 1176: 1169: 1160: 1158: 1143: 1142: 1138: 1101: 1094: 1058: 1057: 1053: 1023: 1022: 1018: 980: 979: 975: 939: 938: 934: 890: 889: 885: 881: 863:Hypothermia cap 849: 813:carbon monoxide 805:Wernicke's area 789: 755:brain chemistry 720:anti-convulsant 680: 621:Hypemic hypoxia 606:Hypoxic hypoxia 543: 533: 528: 517: 511: 477:Low heart rate. 437:breech position 394: 388: 239:deep-water dive 214: 202:hypoxic hypoxia 154: 119:Cases of total 112:cell death via 98:cerebral anoxia 62: 40: 35: 28: 23: 22: 18:Cerebral anoxia 15: 12: 11: 5: 4002: 4000: 3992: 3991: 3986: 3981: 3971: 3970: 3964: 3963: 3960: 3959: 3957: 3956: 3950: 3948: 3942: 3941: 3939: 3938: 3933: 3928: 3923: 3918: 3917: 3916: 3906: 3901: 3896: 3891: 3885: 3883: 3874: 3872:Blood pressure 3868: 3867: 3865: 3864: 3859: 3854: 3849: 3848: 3847: 3842: 3837: 3827: 3826: 3825: 3820: 3809: 3807: 3803: 3802: 3799: 3798: 3796: 3795: 3790: 3785: 3780: 3775: 3769: 3767: 3763: 3762: 3760: 3759: 3754: 3753: 3752: 3747: 3742: 3732: 3726: 3724: 3722:Varicose veins 3718: 3717: 3715: 3714: 3709: 3708: 3707: 3697: 3696: 3695: 3690: 3680: 3679: 3678: 3673: 3668: 3663: 3658: 3648: 3647: 3646: 3635: 3633: 3622: 3621: 3619: 3618: 3612: 3610: 3601: 3595: 3594: 3591: 3590: 3588: 3587: 3585:Spider angioma 3582: 3577: 3571: 3569: 3567:Vascular nevus 3563: 3562: 3560: 3559: 3558: 3557: 3552: 3545:Telangiectasia 3542: 3537: 3531: 3529: 3523: 3522: 3520: 3519: 3518: 3517: 3512: 3507: 3502: 3497: 3487: 3482: 3480:Aortic rupture 3477: 3472: 3471: 3470: 3465: 3460: 3445: 3443: 3441:pseudoaneurysm 3428: 3427: 3424: 3423: 3421: 3420: 3415: 3410: 3405: 3400: 3394: 3392: 3388: 3387: 3385: 3384: 3379: 3373: 3371: 3365: 3364: 3362: 3361: 3360: 3359: 3354: 3352:Oxycholesterol 3349: 3344: 3339: 3334: 3324: 3318: 3317: 3316: 3315: 3310: 3305: 3300: 3295: 3284: 3282: 3273: 3267: 3266: 3264: 3263: 3258: 3257: 3256: 3245: 3243: 3234: 3219: 3218: 3212: 3210: 3209: 3202: 3195: 3187: 3178: 3177: 3174: 3173: 3170: 3169: 3167: 3166: 3165: 3164: 3153: 3152: 3151: 3150: 3149: 3148: 3143: 3133: 3128: 3127: 3126: 3121: 3116: 3115: 3114: 3109: 3104: 3096: 3091: 3086: 3081: 3076: 3066: 3052: 3051: 3050: 3049: 3044: 3039: 3025: 3023: 3017: 3016: 3014: 3013: 3008: 3002: 3000: 2991: 2982: 2978: 2977: 2974: 2973: 2971: 2970: 2965: 2960: 2955: 2950: 2945: 2939: 2937: 2933: 2932: 2930: 2929: 2924: 2922:Cerebral edema 2919: 2918: 2917: 2912: 2907: 2902: 2891: 2889: 2883: 2882: 2879: 2878: 2876: 2875: 2874: 2873: 2871:Template:Sleep 2861: 2859: 2855: 2854: 2852: 2851: 2845: 2840: 2834: 2832: 2826: 2825: 2823: 2822: 2816: 2811: 2806: 2800: 2798: 2792: 2791: 2789: 2788: 2782: 2777: 2772: 2766: 2764: 2751: 2743: 2742: 2740: 2739: 2733: 2728: 2723: 2717: 2715: 2709: 2708: 2705: 2704: 2702: 2701: 2699:Leigh syndrome 2695: 2693: 2687: 2686: 2684: 2683: 2672: 2671: 2666: 2661: 2660: 2659: 2645: 2644: 2643: 2638: 2637: 2636: 2620: 2618: 2612: 2611: 2609: 2608: 2603: 2598: 2597: 2596: 2591: 2580: 2579: 2578: 2577: 2572: 2571: 2570: 2560: 2559: 2558: 2548: 2543: 2542: 2541: 2536: 2531: 2526: 2510: 2509: 2508: 2507: 2502: 2497: 2492: 2487: 2486: 2485: 2475: 2474: 2473: 2463: 2462: 2461: 2456: 2451: 2435: 2433: 2426:Extrapyramidal 2419: 2410: 2408:encephalopathy 2399: 2398: 2395: 2394: 2392: 2391: 2386: 2381: 2380: 2379: 2368: 2366: 2359: 2358: 2356: 2355: 2354: 2353: 2343: 2338: 2337: 2336: 2331: 2326: 2321: 2310: 2308: 2299: 2293: 2292: 2285:nervous system 2282: 2280: 2279: 2272: 2265: 2257: 2251: 2250: 2241: 2240: 2237: 2236: 2224: 2223: 2221: 2217: 2216: 2213: 2212: 2201: 2190: 2174: 2169: 2168: 2166: 2165:Classification 2158: 2157:External links 2155: 2153: 2152: 2117: 2090: 2047: 2022: 1997: 1987:. ScienceDaily 1972: 1940:(4): 218–220. 1920: 1909:Free full text 1893: 1881: 1872: 1851:(6): 834–842. 1825: 1780: 1723: 1704: 1669: 1661:on 2003-09-21. 1646: 1626: 1591: 1568: 1559: 1538:(8): 493–495. 1518: 1496: 1469: 1428: 1387: 1360:(3): 280–285. 1344: 1303: 1262: 1227: 1210:(2018-03-08). 1196: 1167: 1136: 1132:NCBI Bookshelf 1092: 1051: 1032:(1): 107–121. 1016: 989:(3): 960–967. 973: 952:(5): 525–534. 932: 882: 880: 877: 876: 875: 870: 868:Space exposure 865: 860: 855: 848: 845: 841:muscle wasting 788: 785: 679: 676: 675: 674: 662: 647:Cerebral edema 639:cardiac arrest 628: 618: 598: 597: 585: 579: 553: 532: 531:Classification 529: 527: 524: 513:Main article: 510: 507: 506: 505: 502: 499: 496: 493: 490: 487: 484: 481: 478: 475: 472: 457:Sarnat staging 425:umbilical cord 387: 384: 383: 382: 341: 277:drug overdoses 243:high altitudes 213: 210: 153: 150: 146:cardiac arrest 142:birth asphyxia 77: 76: 71: 65: 64: 56: 55: 47: 46: 38: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4001: 3990: 3987: 3985: 3982: 3980: 3977: 3976: 3974: 3955: 3952: 3951: 3949: 3947: 3943: 3937: 3934: 3932: 3929: 3927: 3924: 3922: 3919: 3915: 3912: 3911: 3910: 3907: 3905: 3902: 3900: 3897: 3895: 3892: 3890: 3887: 3886: 3884: 3882: 3878: 3875: 3873: 3869: 3863: 3860: 3858: 3855: 3853: 3850: 3846: 3843: 3841: 3838: 3836: 3833: 3832: 3831: 3828: 3824: 3821: 3819: 3816: 3815: 3814: 3811: 3810: 3808: 3804: 3794: 3791: 3789: 3786: 3784: 3781: 3779: 3776: 3774: 3771: 3770: 3768: 3764: 3758: 3755: 3751: 3748: 3746: 3743: 3741: 3740:Caput medusae 3738: 3737: 3736: 3733: 3731: 3728: 3727: 3725: 3723: 3719: 3713: 3710: 3706: 3703: 3702: 3701: 3698: 3694: 3691: 3689: 3686: 3685: 3684: 3681: 3677: 3674: 3672: 3669: 3667: 3664: 3662: 3659: 3657: 3654: 3653: 3652: 3649: 3645: 3642: 3641: 3640: 3637: 3636: 3634: 3632: 3627: 3623: 3617: 3614: 3613: 3611: 3609: 3605: 3602: 3600: 3596: 3586: 3583: 3581: 3578: 3576: 3573: 3572: 3570: 3568: 3564: 3556: 3553: 3551: 3548: 3547: 3546: 3543: 3541: 3538: 3536: 3533: 3532: 3530: 3528: 3524: 3516: 3513: 3511: 3508: 3506: 3503: 3501: 3498: 3496: 3493: 3492: 3491: 3488: 3486: 3483: 3481: 3478: 3476: 3473: 3469: 3466: 3464: 3461: 3459: 3456: 3455: 3454: 3450: 3447: 3446: 3444: 3442: 3437: 3433: 3429: 3419: 3416: 3414: 3411: 3409: 3406: 3404: 3403:Degos disease 3401: 3399: 3396: 3395: 3393: 3389: 3383: 3380: 3378: 3375: 3374: 3372: 3370: 3366: 3358: 3355: 3353: 3350: 3348: 3345: 3343: 3340: 3338: 3335: 3333: 3330: 3329: 3328: 3325: 3323: 3320: 3319: 3314: 3311: 3309: 3306: 3304: 3301: 3299: 3296: 3294: 3291: 3290: 3289: 3286: 3285: 3283: 3281: 3277: 3274: 3272: 3268: 3262: 3259: 3255: 3252: 3251: 3250: 3247: 3246: 3244: 3242: 3238: 3235: 3233: 3228: 3224: 3220: 3215: 3208: 3203: 3201: 3196: 3194: 3189: 3188: 3185: 3163: 3160: 3159: 3158: 3155: 3154: 3147: 3144: 3142: 3139: 3138: 3137: 3134: 3132: 3129: 3125: 3122: 3120: 3117: 3113: 3110: 3108: 3105: 3103: 3100: 3099: 3097: 3095: 3092: 3090: 3087: 3085: 3082: 3080: 3077: 3075: 3072: 3071: 3070: 3067: 3065: 3062: 3061: 3060: 3058: 3054: 3053: 3048: 3045: 3043: 3040: 3038: 3035: 3034: 3033: 3031: 3027: 3026: 3024: 3022: 3018: 3012: 3009: 3007: 3004: 3003: 3001: 2999: 2995: 2992: 2990: 2986: 2983: 2979: 2969: 2966: 2964: 2961: 2959: 2956: 2954: 2951: 2949: 2948:Reye syndrome 2946: 2944: 2941: 2940: 2938: 2934: 2928: 2925: 2923: 2920: 2916: 2913: 2911: 2908: 2906: 2903: 2901: 2900:Hydrocephalus 2898: 2897: 2896: 2893: 2892: 2890: 2888: 2884: 2872: 2868: 2867: 2866: 2863: 2862: 2860: 2856: 2850: 2846: 2844: 2841: 2839: 2836: 2835: 2833: 2831: 2827: 2821: 2817: 2815: 2812: 2810: 2807: 2805: 2802: 2801: 2799: 2797: 2793: 2787: 2783: 2781: 2778: 2776: 2773: 2771: 2768: 2767: 2765: 2763: 2759: 2755: 2752: 2750: 2744: 2738: 2734: 2732: 2729: 2727: 2724: 2722: 2719: 2718: 2716: 2714: 2713:Demyelinating 2710: 2700: 2697: 2696: 2694: 2692: 2688: 2682: 2679: 2678: 2677: 2676: 2670: 2667: 2665: 2662: 2658: 2655: 2654: 2653: 2649: 2646: 2642: 2639: 2635: 2632: 2631: 2630: 2627: 2626: 2625: 2622: 2621: 2619: 2617: 2613: 2607: 2604: 2602: 2601:Restless legs 2599: 2595: 2592: 2590: 2587: 2586: 2585: 2582: 2581: 2576: 2573: 2569: 2566: 2565: 2564: 2561: 2557: 2554: 2553: 2552: 2549: 2547: 2544: 2540: 2539:Blepharospasm 2537: 2535: 2532: 2530: 2527: 2525: 2522: 2521: 2520: 2517: 2516: 2515: 2512: 2511: 2506: 2503: 2501: 2498: 2496: 2495:Hemiballismus 2493: 2491: 2488: 2484: 2481: 2480: 2479: 2476: 2472: 2469: 2468: 2467: 2464: 2460: 2457: 2455: 2452: 2450: 2447: 2446: 2445: 2442: 2441: 2440: 2437: 2436: 2434: 2432: 2427: 2423: 2420: 2418: 2414: 2411: 2409: 2404: 2400: 2390: 2387: 2385: 2382: 2378: 2375: 2374: 2373: 2370: 2369: 2367: 2365: 2360: 2352: 2349: 2348: 2347: 2346:Brain abscess 2344: 2342: 2339: 2335: 2332: 2330: 2327: 2325: 2322: 2320: 2317: 2316: 2315: 2312: 2311: 2309: 2307: 2303: 2300: 2298: 2294: 2290: 2286: 2278: 2273: 2271: 2266: 2264: 2259: 2258: 2255: 2249: 2246: 2245: 2235: 2231: 2230: 2226: 2225: 2222: 2218: 2211: 2207: 2206: 2202: 2200: 2196: 2195: 2191: 2189: 2185: 2184: 2180: 2176: 2175: 2172: 2167: 2163: 2156: 2148: 2144: 2140: 2136: 2132: 2128: 2121: 2118: 2113: 2109: 2105: 2101: 2094: 2091: 2086: 2082: 2078: 2074: 2070: 2066: 2062: 2058: 2051: 2048: 2037: 2033: 2026: 2023: 2012: 2011:New Scientist 2008: 2001: 1998: 1986: 1982: 1976: 1973: 1968: 1962: 1947: 1943: 1939: 1935: 1931: 1924: 1921: 1917: 1913: 1910: 1906: 1900: 1898: 1894: 1890: 1885: 1882: 1876: 1873: 1868: 1864: 1859: 1854: 1850: 1846: 1845: 1840: 1836: 1829: 1826: 1821: 1817: 1813: 1809: 1805: 1801: 1797: 1793: 1792: 1784: 1781: 1776: 1772: 1767: 1762: 1758: 1754: 1750: 1746: 1742: 1738: 1734: 1727: 1724: 1720: 1719: 1714: 1708: 1705: 1693:on 2007-02-08 1692: 1688: 1684: 1680: 1673: 1670: 1666: 1660: 1656: 1650: 1647: 1644: 1640: 1636: 1630: 1627: 1622: 1618: 1614: 1610: 1607:(3): 583–56. 1606: 1602: 1595: 1592: 1588: 1582: 1578: 1572: 1569: 1563: 1560: 1555: 1551: 1546: 1541: 1537: 1533: 1529: 1522: 1519: 1506: 1505:"Parent Info" 1500: 1497: 1486: 1482: 1476: 1474: 1470: 1465: 1461: 1456: 1451: 1447: 1443: 1439: 1432: 1429: 1424: 1420: 1415: 1410: 1406: 1402: 1398: 1391: 1388: 1383: 1379: 1375: 1371: 1367: 1363: 1359: 1355: 1348: 1345: 1340: 1336: 1331: 1326: 1322: 1318: 1314: 1307: 1304: 1299: 1295: 1290: 1285: 1281: 1277: 1273: 1266: 1263: 1258: 1254: 1250: 1246: 1242: 1238: 1231: 1228: 1217: 1213: 1209: 1203: 1201: 1197: 1191: 1180: 1174: 1172: 1168: 1156: 1152: 1151: 1146: 1140: 1137: 1133: 1129: 1125: 1124:0-397-51820-X 1121: 1117: 1113: 1109: 1105: 1099: 1097: 1093: 1088: 1084: 1079: 1074: 1070: 1066: 1062: 1055: 1052: 1047: 1043: 1039: 1035: 1031: 1027: 1020: 1017: 1012: 1008: 1004: 1000: 996: 992: 988: 984: 977: 974: 969: 965: 960: 955: 951: 947: 943: 936: 933: 928: 924: 920: 916: 912: 908: 904: 900: 899: 894: 887: 884: 878: 874: 871: 869: 866: 864: 861: 859: 856: 854: 851: 850: 846: 844: 842: 838: 832: 828: 826: 822: 818: 814: 809: 806: 802: 798: 793: 786: 784: 781: 779: 775: 771: 770:blood glucose 767: 762: 760: 756: 752: 748: 747:free radicals 744: 739: 737: 733: 729: 728:free radicals 723: 721: 717: 713: 709: 705: 704:defibrilation 701: 697: 693: 688: 685: 677: 672: 668: 667: 663: 660: 656: 655:hydrocephalus 652: 648: 644: 640: 636: 632: 629: 626: 622: 619: 616: 612: 608: 607: 603: 602: 601: 595: 591: 590: 586: 583: 580: 577: 573: 569: 565: 561: 557: 554: 551: 548: 547: 540: 536: 530: 525: 523: 522: 516: 508: 503: 500: 497: 494: 491: 488: 485: 482: 479: 476: 473: 470: 469: 468: 466: 462: 458: 453: 451: 447: 442: 438: 434: 430: 426: 421: 419: 415: 411: 407: 403: 399: 393: 385: 380: 376: 372: 368: 364: 360: 355: 351: 347: 346: 345:Silent stroke 342: 339: 335: 334:contralateral 331: 327: 323: 319: 315: 311: 307: 306: 302: 301: 300: 298: 294: 293:fainting game 290: 286: 282: 278: 274: 270: 269:strangulation 266: 262: 257: 255: 251: 248: 247:unpressurized 244: 240: 236: 232: 228: 224: 220: 211: 209: 205: 203: 198: 196: 192: 188: 184: 180: 176: 170: 167: 158: 151: 149: 147: 143: 139: 135: 131: 127: 122: 117: 115: 111: 107: 103: 99: 95: 91: 87: 84:is a form of 83: 75: 72: 70: 66: 61: 57: 53: 48: 43: 37: 33: 19: 3881:Hypertension 3793:Venous ulcer 3699: 3682: 3650: 3638: 3608:Inflammation 3489: 3448: 3337:Hyperplastic 3298:Fatty streak 3241:Inflammation 3156: 3055: 3028: 2989:Degenerative 2726:Inflammatory 2673: 2606:Stiff-person 2444:Parkinsonism 2417:Degenerative 2314:Encephalitis 2297:Inflammation 2287:, primarily 2227: 2203: 2192: 2177: 2130: 2126: 2120: 2106:(2): 78–84. 2103: 2099: 2093: 2060: 2056: 2050: 2039:. Retrieved 2025: 2014:. Retrieved 2000: 1989:. Retrieved 1975: 1961:cite journal 1950:. Retrieved 1937: 1933: 1923: 1904: 1884: 1875: 1848: 1842: 1835:Saugstad, OD 1828: 1795: 1789: 1783: 1740: 1736: 1726: 1716: 1707: 1695:. Retrieved 1691:the original 1682: 1672: 1659:the original 1649: 1634: 1629: 1604: 1600: 1594: 1580: 1571: 1562: 1535: 1531: 1521: 1509:. Retrieved 1499: 1488:. Retrieved 1484: 1445: 1441: 1431: 1407:(1): 21–25. 1404: 1400: 1390: 1357: 1353: 1347: 1320: 1316: 1306: 1279: 1275: 1265: 1240: 1236: 1230: 1219:. Retrieved 1159:. 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Index

Cerebral anoxia
Hypoxia

Circle of Willis
Specialty
Critical care medicine
hypoxia
oxygen
brain
ischemia
cerebral infarction
neuronal
apoptosis
oxygen deprivation
birth asphyxia
cardiac arrest

brain tissue
short-term memory
cyanosis
fainting
coma
cessation of brain stem reflexes
brain death
hypoxic hypoxia
blood oxygenation
asthma
anemia
status epilepticus
nitrogen

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