657:
51:
42:
3874:
631:(EMA) issued a positive opinion recommending that the European Commission grant a marketing authorisation for Cimzia for the treatment of rheumatoid arthritis only - the CHMP refused approval for the treatment of Crohn's disease. The marketing authorisation was granted to UCB Pharma SA in October 2009.
1194:
Schreiber S, Khaliq-Kareemi M, Lawrance I, Hanauer S, McColm J, Bloomfield R, et al. (2005). "Certolizumab pegol, a humanised anti-TNF pegylated FAb' fragment, is safe and effective in the maintenance of response and remission following induction in active Crohn's disease: a phase 3 study
1214:
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, McColm JA, et al. (2006). "Certolizumab pegol administered subcutaneously is effective and well tolerated in patients with active Crohn's disease: results from a 26-week, placebo-controlled Phase 3 study (PRECiSE 1)".
1262:"PMS50 – Rapid Improvements In Patient-Reported Outcomes With Certolizumab Pegol In Patients With Axial Spondyloarthritis, Including Ankylosing Spondylitis And Non-Radiographic Axial Spondyloarthritis: 24-Week Results Of A Phase 3 Double Blind Randomized Placebo-Controlled Study"
721:
In 2013, a phase 3 double blind randomized placebo-controlled study found significantly positive results in patient self-reported questionnaires, with rapid improvement of function and pain reduction, in patients with
1114:
279:
2819:
3914:
234:
536:
1118:
3924:
624:
1234:
132:
1377:
640:
2812:
68:
2293:
2805:
891:
825:
1142:"Molecular Basis for the Neutralization of Tumor Necrosis Factor α by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases"
3828:
1035:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
596:
615:(FDA) approved Cimzia for the treatment of Crohn's disease in people who did not respond sufficiently or adequately to standard therapy.
2236:
1606:
1058:
1370:
788:
2645:
264:
164:
183:
3919:
3800:
3864:
3810:
1442:
1006:
664:
of TNF-alpha (tan). Certolizumab can block TNF in both its soluble form (freely circulating in the bloodstream) and its
612:
413:
656:
3909:
3904:
3845:
1551:
1363:
1238:
1115:"Cimzia (certolizumab pegol) approved by the U.S. FDA for treatment of adult patients with active psoriatic arthritis"
683:
585:
227:
1421:
1235:"New Analysis Shows Cimzia (Certolizumab Pegol) Maintained Remission and Response in Recent Onset Crohn's Disease"
3394:
2099:
1030:
821:
628:
2479:
1349:
709:
Positive results have been demonstrated in two phase III trials (PRECiSE 1 and 2) of certolizumab pegol versus
690:
1000:
3899:
3833:
2474:
723:
220:
3894:
2279:
1705:
1386:
577:
462:
50:
757:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2906:
2828:
2466:
885:
3110:
1355:
756:
735:
569:
322:
1687:
644:
581:
573:
357:
80:
61:
1293:
Ruiz Garcia V, Burls A, Cabello JB, Vela
Casasempere P, Bort-Marti S, Bernal JA (September 2017).
3254:
3094:
2886:
2636:
979:
194:
2676:
2534:
565:
2686:
2372:
1813:
850:
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, et al. (July 2007).
3186:
2856:
2797:
2641:
2631:
1432:
1390:
1345:
1324:
1173:
971:
936:
873:
670:
561:
114:
817:
3176:
3166:
2437:
2340:
2003:
1899:
1314:
1306:
1273:
1163:
1153:
1038:
963:
926:
918:
863:
478:
366:
314:
73:
422:
3878:
3594:
3370:
2736:
2621:
142:
1066:
3839:
2626:
2494:
2142:
1976:
1955:
1951:
1947:
1575:
1412:
1319:
1294:
1168:
1141:
931:
906:
3888:
3749:
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3495:
3420:
3380:
3300:
3194:
2840:
2832:
2776:
2706:
2616:
2523:
2309:
2009:
1931:
1883:
1863:
1721:
1637:
1488:
1454:
954:
Kaushik VV, Moots RJ (April 2005). "CDP-870 (certolizumab) in rheumatoid arthritis".
694:
665:
589:
292:
156:
983:
3739:
3724:
3704:
3694:
3673:
3589:
3530:
3515:
3485:
3465:
3460:
3435:
3415:
3410:
3405:
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3335:
3285:
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3204:
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3073:
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2726:
2442:
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2105:
2090:
2038:
2014:
1961:
1838:
1828:
1647:
1564:
1559:
1517:
1470:
1427:
1394:
1310:
1059:"Cimzia Approved in the US for the Treatment of Moderate to Severe Crohn's Disease"
247:
242:
33:
3805:
3795:
3734:
3719:
3709:
3699:
3678:
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3199:
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3131:
3099:
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3027:
3007:
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2134:
2129:
2115:
2095:
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1982:
1966:
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1752:
1657:
1569:
1527:
1512:
1506:
1502:
1449:
1278:
1261:
150:
41:
789:"Cimzia- certolizumab pegol kit Cimzia- certolizumab pegol injection, solution"
3765:
3744:
3729:
3714:
3658:
3653:
3633:
3628:
3599:
3573:
3510:
3490:
3475:
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3400:
3350:
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3305:
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3161:
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3146:
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3063:
3058:
3047:
3017:
3012:
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2407:
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2214:
2209:
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2062:
2019:
1915:
1905:
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1818:
1808:
1803:
1798:
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1732:
1727:
1711:
1652:
1632:
1581:
1541:
1522:
1464:
661:
517:
397:
1089:
967:
3668:
3500:
3325:
3224:
3209:
3068:
3032:
3022:
2996:
2991:
2971:
2946:
2941:
2926:
2921:
2891:
2861:
2761:
2756:
2741:
2716:
2671:
2651:
2611:
2546:
2510:
2432:
2228:
2181:
2110:
2076:
2043:
1853:
1833:
1742:
1642:
1482:
687:
335:
136:
102:
85:
17:
1328:
1177:
975:
940:
922:
877:
3078:
3001:
2911:
2881:
2696:
2571:
2260:
1768:
1678:
1614:
1536:
1158:
1093:
868:
851:
377:
344:
178:
1043:
386:
3555:
3440:
2189:
710:
97:
674:
3780:
2504:
2335:
453:
340:
1260:
Sieper J, Tubergen A, Coteur G, Woltering F, Landewe R (May 2013).
995:
993:
442:
2203:
2056:
655:
89:
2175:
2123:
2084:
2070:
1624:
1498:
1295:"Certolizumab pegol (CDP870) for rheumatoid arthritis in adults"
1001:"Drug Approval Package: Cimzia (Certolizumab Pegol) NDA #125160"
643:
approved Cimzia for the treatment of adult patients with active
433:
301:
2801:
1359:
286:
173:
2032:
764:
682:
Certolizumab pegol is a monoclonal antibody directed against
273:
205:
852:"Certolizumab pegol for the treatment of Crohn's disease"
1140:
Lee JU, Shin W, Son JY, Yoo KY, Heo YS (January 2017).
597:
543:
1237:(Press release). UCB. October 23, 2006. Archived from
3862:
3788:
3778:
3758:
3687:
3621:
3612:
3581:
3253:
3185:
3119:
2848:
2839:
2564:
2492:
2465:
2350:
1993:
1695:
1686:
1677:
1670:
1623:
1605:
1596:
1550:
1481:
1411:
1402:
516:
477:
472:
452:
432:
412:
396:
376:
356:
351:
334:
321:
313:
263:
258:
233:
219:
193:
163:
149:
131:
123:
113:
108:
96:
79:
67:
60:
783:
781:
365:
845:
843:
734:Certolizumab appears beneficial in those with
660:Three certolizumab molecules (blue) binding a
625:Committee for Medicinal Products for Human Use
3915:World Health Organization essential medicines
2813:
1371:
812:
810:
713:in moderate to severe active Crohn's disease.
668:form (bound to the membrane of a cell). From
8:
1189:
1187:
182:
32:
1299:The Cochrane Database of Systematic Reviews
1146:International Journal of Molecular Sciences
3785:
3618:
2845:
2820:
2806:
2798:
1692:
1683:
1674:
1602:
1408:
1378:
1364:
1356:
1090:"FDA Approvals: Patanase, Actonel, Cimzia"
49:
40:
1348:at the U.S. National Library of Medicine
1318:
1277:
1167:
1157:
1042:
930:
867:
421:
3869:
748:
385:
155:
883:
31:
3925:Disease-modifying antirheumatic drugs
1037:. Geneva: World Health Organization.
828:from the original on November 9, 2009
461:
141:
55:Syringe with 200mg Certolizumab pegol
7:
956:Expert Opinion on Biological Therapy
246:
856:The New England Journal of Medicine
441:
890:: CS1 maint: overridden setting (
25:
3872:
564:medication for the treatment of
495:
489:
588:(TNF-α) and is manufactured by
1311:10.1002/14651858.CD007649.pub4
507:
501:
483:
1:
1443:dihydroorotate dehydrogenase
1007:Food and Drug Administration
613:Food and Drug Administration
611:On April 22, 2008, the U.S.
556:, sold under the brand name
1422:purine synthesis inhibitors
1279:10.1016/j.jval.2013.03.1150
905:Goel N, Stephens S (2010).
684:tumor necrosis factor alpha
639:On September 27, 2013, the
586:tumor necrosis factor alpha
3941:
1047:. WHO/MHP/HPS/EML/2023.02.
686:. More precisely, it is a
473:Chemical and physical data
3823:
1607:IL-1 receptor antagonists
1088:Waknine Y (May 1, 2008).
1031:World Health Organization
822:European Medicines Agency
629:European Medicines Agency
533:
48:
39:
2480:Anti-lymphocyte globulin
1350:Medical Subject Headings
968:10.1517/14712598.5.4.601
693:fragment of a humanized
580:. It is a fragment of a
2475:Anti-thymocyte globulin
1387:Immunosuppressive drugs
724:axial spondyloarthritis
718:Axial spondyloarthritis
2280:Interleukin-6 receptor
1706:Complement component 5
923:10.4161/mabs.2.2.11271
679:
623:On June 26, 2009, the
578:ankylosing spondylitis
3920:Monoclonal antibodies
2907:Camidanlumab tesirine
2829:Monoclonal antibodies
697:monoclonal antibody.
659:
3582:Chimeric + humanized
3111:Nivolumab/relatlimab
1159:10.3390/ijms18010228
1069:on February 18, 2012
907:"Certolizumab pegol"
869:10.1056/NEJMoa067594
824:. October 22, 2009.
736:rheumatoid arthritis
731:Rheumatoid arthritis
620:Rheumatoid arthritis
570:rheumatoid arthritis
1011:. December 24, 1999
645:psoriatic arthritis
636:Psoriatic arthritis
582:monoclonal antibody
574:psoriatic arthritis
282:(Prescription only)
62:Monoclonal antibody
36:
27:Pharmaceutical drug
3910:Belgian inventions
3905:Immunosuppressants
3850:Never to phase III
3296:Certolizumab pegol
3263:Immunosuppressive:
2637:Diroximel fumarate
2310:IL-2 receptor/CD25
1738:Certolizumab pegol
1391:Immunosuppressants
1346:certolizumab+pegol
1121:on October 1, 2013
680:
554:Certolizumab pegol
184:Certolizumab pegol
34:Certolizumab pegol
3860:
3859:
3819:
3818:
3774:
3773:
3608:
3607:
3563:Immune activation
3055:Immune activation
2857:Immunosuppression
2795:
2794:
2642:Efgartigimod alfa
2632:Dimethyl fumarate
2560:
2559:
2488:
2487:
2461:
2460:
1666:
1665:
1592:
1591:
1433:Mycophenolic acid
1241:on March 29, 2020
1063:UCB press release
562:biopharmaceutical
551:
550:
305:
290:
277:
209:
176:
16:(Redirected from
3932:
3877:
3876:
3875:
3868:
3786:
3619:
3177:Zolimomab aritox
3167:Telimomab aritox
2846:
2822:
2815:
2808:
2799:
2438:Telimomab aritox
2341:Zolimomab aritox
2162:CD62L/L-selectin
1900:Immunoglobulin E
1693:
1684:
1675:
1603:
1409:
1380:
1373:
1366:
1357:
1333:
1332:
1322:
1290:
1284:
1283:
1281:
1257:
1251:
1250:
1248:
1246:
1231:
1225:
1224:
1217:Gastroenterology
1211:
1205:
1204:
1191:
1182:
1181:
1171:
1161:
1137:
1131:
1130:
1128:
1126:
1117:. Archived from
1111:
1105:
1104:
1102:
1100:
1085:
1079:
1078:
1076:
1074:
1065:. Archived from
1055:
1049:
1048:
1046:
1027:
1021:
1020:
1018:
1016:
997:
988:
987:
951:
945:
944:
934:
902:
896:
895:
889:
881:
871:
847:
838:
837:
835:
833:
814:
805:
804:
802:
800:
795:. April 24, 2020
785:
776:
775:
773:
771:
761:nctr-crs.fda.gov
753:
677:
652:Method of action
547:
546:
539:
528:
526:
509:
503:
497:
491:
485:
465:
445:
425:
389:
369:
326:
303:
300:
295:
288:
285:
275:
272:
250:
207:
204:
186:
175:
172:
159:
145:
53:
44:
37:
35:
21:
3940:
3939:
3935:
3934:
3933:
3931:
3930:
3929:
3885:
3884:
3883:
3873:
3871:
3863:
3861:
3856:
3855:
3840:Clinical trials
3815:
3770:
3754:
3683:
3604:
3595:Rozanolixizumab
3583:
3577:
3569:
3558:
3371:Lulizumab pegol
3249:
3181:
3115:
2835:
2826:
2796:
2791:
2737:Rozanolixizumab
2622:Deucravacitinib
2556:
2484:
2457:
2346:
1995:
1989:
1697:
1662:
1619:
1598:
1588:
1546:
1486:
1477:
1413:Antimetabolites
1404:
1398:
1384:
1342:
1337:
1336:
1305:(9): CD007649.
1292:
1291:
1287:
1266:Value in Health
1259:
1258:
1254:
1244:
1242:
1233:
1232:
1228:
1213:
1212:
1208:
1203:(suppl 7): A82.
1193:
1192:
1185:
1139:
1138:
1134:
1124:
1122:
1113:
1112:
1108:
1098:
1096:
1087:
1086:
1082:
1072:
1070:
1057:
1056:
1052:
1029:
1028:
1024:
1014:
1012:
999:
998:
991:
953:
952:
948:
904:
903:
899:
882:
849:
848:
841:
831:
829:
816:
815:
808:
798:
796:
787:
786:
779:
769:
767:
755:
754:
750:
745:
706:Crohn's disease
703:
701:Clinical trials
669:
654:
608:Crohn's Disease
605:
566:Crohn's disease
542:
540:
537:(what is this?)
534:
524:
522:
512:
506:
500:
494:
488:
468:
448:
428:
408:
392:
372:
324:
315:Pharmacokinetic
309:
293:
254:
222:
215:
196:
189:
56:
28:
23:
22:
15:
12:
11:
5:
3938:
3936:
3928:
3927:
3922:
3917:
3912:
3907:
3902:
3900:TNF inhibitors
3897:
3887:
3886:
3882:
3881:
3858:
3857:
3854:
3853:
3852:
3851:
3848:
3837:
3831:
3825:
3824:
3821:
3820:
3817:
3816:
3814:
3813:
3808:
3803:
3798:
3792:
3790:
3783:
3776:
3775:
3772:
3771:
3769:
3768:
3762:
3760:
3756:
3755:
3753:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3691:
3689:
3685:
3684:
3682:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3625:
3623:
3616:
3610:
3609:
3606:
3605:
3603:
3602:
3597:
3592:
3586:
3584:
3579:
3578:
3560:
3559:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3448:
3443:
3438:
3433:
3428:
3423:
3418:
3413:
3408:
3403:
3398:
3395:+hyaluronidase
3388:
3383:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3288:
3283:
3278:
3273:
3268:
3259:
3257:
3251:
3250:
3248:
3247:
3242:
3237:
3232:
3227:
3222:
3217:
3212:
3207:
3202:
3197:
3191:
3189:
3183:
3182:
3180:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3123:
3121:
3117:
3116:
3114:
3113:
3103:
3102:
3097:
3092:
3082:
3081:
3076:
3071:
3066:
3061:
3051:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
2999:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2869:
2864:
2852:
2850:
2843:
2837:
2836:
2827:
2825:
2824:
2817:
2810:
2802:
2793:
2792:
2790:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2646:+hyaluronidase
2639:
2634:
2629:
2627:Deuruxolitinib
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2568:
2566:
2562:
2561:
2558:
2557:
2555:
2554:
2549:
2544:
2539:
2538:
2537:
2532:
2520:
2519:
2518:
2513:
2500:
2498:
2490:
2489:
2486:
2485:
2483:
2482:
2477:
2471:
2469:
2463:
2462:
2459:
2458:
2456:
2455:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2405:
2400:
2395:
2390:
2385:
2380:
2375:
2370:
2365:
2360:
2354:
2352:
2348:
2347:
2345:
2344:
2331:
2330:
2329:
2328:
2323:
2318:
2305:
2304:
2303:
2302:
2290:
2289:
2288:
2276:
2275:
2274:
2269:
2257:
2256:
2255:
2250:
2245:
2233:
2232:
2231:
2220:
2219:
2218:
2217:
2212:
2200:
2199:
2198:
2186:
2185:
2184:
2172:
2171:
2170:
2158:
2157:
2156:
2151:
2139:
2138:
2137:
2132:
2120:
2119:
2118:
2113:
2108:
2103:
2100:+hyaluronidase
2093:
2081:
2080:
2079:
2067:
2066:
2065:
2053:
2052:
2051:
2046:
2041:
2029:
2028:
2027:
2022:
2017:
2012:
1999:
1997:
1991:
1990:
1988:
1987:
1986:
1985:
1972:
1971:
1970:
1969:
1964:
1943:
1942:
1941:
1940:
1927:
1926:
1925:
1924:
1911:
1910:
1909:
1908:
1895:
1894:
1893:
1892:
1879:
1878:
1877:
1876:
1871:
1866:
1861:
1856:
1851:
1846:
1841:
1836:
1831:
1826:
1821:
1816:
1811:
1806:
1801:
1796:
1791:
1786:
1781:
1776:
1771:
1758:
1757:
1756:
1755:
1750:
1745:
1740:
1735:
1730:
1717:
1716:
1715:
1714:
1701:
1699:
1690:
1681:
1672:
1668:
1667:
1664:
1663:
1661:
1660:
1655:
1650:
1645:
1640:
1635:
1629:
1627:
1621:
1620:
1618:
1617:
1611:
1609:
1600:
1594:
1593:
1590:
1589:
1587:
1586:
1585:
1584:
1576:PDE4 inhibitor
1572:
1567:
1562:
1556:
1554:
1548:
1547:
1545:
1544:
1539:
1533:
1532:
1531:
1530:
1525:
1520:
1515:
1494:
1492:
1479:
1478:
1476:
1475:
1474:
1473:
1460:
1459:
1458:
1457:
1452:
1438:
1437:
1436:
1435:
1430:
1417:
1415:
1406:
1400:
1399:
1385:
1383:
1382:
1375:
1368:
1360:
1354:
1353:
1341:
1340:External links
1338:
1335:
1334:
1285:
1252:
1226:
1206:
1183:
1132:
1106:
1080:
1050:
1022:
989:
962:(4): 601–606.
946:
917:(2): 137–147.
897:
862:(3): 228–238.
839:
806:
777:
747:
746:
744:
741:
740:
739:
732:
728:
727:
719:
715:
714:
707:
702:
699:
653:
650:
649:
648:
637:
633:
632:
627:(CHMP) of the
621:
617:
616:
609:
604:
601:
549:
548:
531:
530:
520:
514:
513:
510:
504:
498:
492:
486:
481:
475:
474:
470:
469:
467:
466:
458:
456:
450:
449:
447:
446:
438:
436:
430:
429:
427:
426:
418:
416:
410:
409:
407:
406:
402:
400:
394:
393:
391:
390:
382:
380:
374:
373:
371:
370:
362:
360:
354:
353:
349:
348:
338:
332:
331:
328:
319:
318:
311:
310:
308:
307:
298:
283:
269:
267:
261:
260:
256:
255:
253:
252:
239:
237:
231:
230:
225:
223:administration
217:
216:
214:
213:
211:
201:
199:
191:
190:
188:
187:
169:
167:
161:
160:
153:
147:
146:
139:
129:
128:
125:
121:
120:
117:
111:
110:
106:
105:
100:
94:
93:
83:
77:
76:
71:
65:
64:
58:
57:
54:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3937:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3895:Biotechnology
3893:
3892:
3890:
3880:
3870:
3866:
3849:
3847:
3844:
3843:
3841:
3838:
3835:
3832:
3830:
3827:
3826:
3822:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3793:
3791:
3787:
3784:
3782:
3779:Inflammatory
3777:
3767:
3764:
3763:
3761:
3757:
3751:
3750:Tildrakizumab
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3692:
3690:
3686:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3626:
3624:
3620:
3617:
3615:
3611:
3601:
3598:
3596:
3593:
3591:
3588:
3587:
3585:
3580:
3576:
3575:
3572:
3568:
3564:
3557:
3554:
3552:
3551:Vobarilizumab
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3496:Spartalizumab
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3421:Pembrolizumab
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3396:
3392:
3389:
3387:
3384:
3382:
3381:Mogamulizumab
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3301:Crizanlizumab
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3261:
3260:
3258:
3256:
3252:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3195:Andecaliximab
3193:
3192:
3190:
3188:
3184:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3124:
3122:
3118:
3112:
3108:
3105:
3104:
3101:
3098:
3096:
3093:
3091:
3087:
3084:
3083:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3056:
3053:
3052:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2865:
2863:
2859:
2858:
2854:
2853:
2851:
2847:
2844:
2842:
2841:Immune system
2838:
2834:
2833:immune system
2830:
2823:
2818:
2816:
2811:
2809:
2804:
2803:
2800:
2788:
2785:
2783:
2780:
2778:
2777:Tildrakizumab
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2707:Pegcetacoplan
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2647:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2617:Darvadstrocel
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2569:
2567:
2563:
2553:
2550:
2548:
2545:
2543:
2540:
2536:
2533:
2531:
2528:
2527:
2526:
2525:
2524:TNF inhibitor
2521:
2517:
2514:
2512:
2509:
2508:
2507:
2506:
2502:
2501:
2499:
2496:
2491:
2481:
2478:
2476:
2473:
2472:
2470:
2468:
2464:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2355:
2353:
2349:
2342:
2338:
2337:
2333:
2332:
2327:
2324:
2322:
2319:
2317:
2314:
2313:
2312:
2311:
2307:
2306:
2301:
2298:
2297:
2296:
2295:
2291:
2287:
2284:
2283:
2282:
2281:
2277:
2273:
2270:
2268:
2265:
2264:
2263:
2262:
2258:
2254:
2251:
2249:
2246:
2244:
2241:
2240:
2239:
2238:
2234:
2230:
2227:
2226:
2225:
2222:
2221:
2216:
2213:
2211:
2208:
2207:
2206:
2205:
2201:
2197:
2194:
2193:
2192:
2191:
2190:CD147/Basigin
2187:
2183:
2180:
2179:
2178:
2177:
2173:
2169:
2166:
2165:
2164:
2163:
2159:
2155:
2152:
2150:
2147:
2146:
2145:
2144:
2140:
2136:
2133:
2131:
2128:
2127:
2126:
2125:
2121:
2117:
2114:
2112:
2109:
2107:
2104:
2101:
2097:
2094:
2092:
2089:
2088:
2087:
2086:
2082:
2078:
2075:
2074:
2073:
2072:
2068:
2064:
2061:
2060:
2059:
2058:
2054:
2050:
2047:
2045:
2042:
2040:
2037:
2036:
2035:
2034:
2030:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2010:Muromonab-CD3
2008:
2007:
2006:
2005:
2001:
2000:
1998:
1992:
1984:
1981:
1980:
1979:
1978:
1974:
1973:
1968:
1965:
1963:
1960:
1959:
1958:
1957:
1953:
1949:
1945:
1944:
1939:
1936:
1935:
1934:
1933:
1929:
1928:
1923:
1920:
1919:
1918:
1917:
1913:
1912:
1907:
1904:
1903:
1902:
1901:
1897:
1896:
1891:
1888:
1887:
1886:
1885:
1884:Interleukin 5
1881:
1880:
1875:
1872:
1870:
1867:
1865:
1864:Tildrakizumab
1862:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1815:
1812:
1810:
1807:
1805:
1802:
1800:
1797:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1766:
1765:
1764:
1760:
1759:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1734:
1731:
1729:
1726:
1725:
1724:
1723:
1719:
1718:
1713:
1710:
1709:
1708:
1707:
1703:
1702:
1700:
1698:(noncellular)
1694:
1691:
1689:
1685:
1682:
1680:
1676:
1673:
1671:Extracellular
1669:
1659:
1656:
1654:
1651:
1649:
1646:
1644:
1641:
1639:
1638:Ridaforolimus
1636:
1634:
1631:
1630:
1628:
1626:
1622:
1616:
1613:
1612:
1610:
1608:
1604:
1601:
1597:Intracellular
1595:
1583:
1580:
1579:
1578:
1577:
1573:
1571:
1568:
1566:
1563:
1561:
1558:
1557:
1555:
1553:
1549:
1543:
1540:
1538:
1535:
1534:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1510:
1509:
1508:
1504:
1500:
1496:
1495:
1493:
1490:
1484:
1480:
1472:
1469:
1468:
1467:
1466:
1462:
1461:
1456:
1455:Teriflunomide
1453:
1451:
1448:
1447:
1445:
1444:
1440:
1439:
1434:
1431:
1429:
1426:
1425:
1424:
1423:
1419:
1418:
1416:
1414:
1410:
1407:
1403:Intracellular
1401:
1396:
1392:
1388:
1381:
1376:
1374:
1369:
1367:
1362:
1361:
1358:
1351:
1347:
1344:
1343:
1339:
1330:
1326:
1321:
1316:
1312:
1308:
1304:
1300:
1296:
1289:
1286:
1280:
1275:
1271:
1267:
1263:
1256:
1253:
1240:
1236:
1230:
1227:
1222:
1218:
1210:
1207:
1202:
1198:
1190:
1188:
1184:
1179:
1175:
1170:
1165:
1160:
1155:
1151:
1147:
1143:
1136:
1133:
1120:
1116:
1110:
1107:
1095:
1091:
1084:
1081:
1068:
1064:
1060:
1054:
1051:
1045:
1040:
1036:
1032:
1026:
1023:
1010:
1008:
1002:
996:
994:
990:
985:
981:
977:
973:
969:
965:
961:
957:
950:
947:
942:
938:
933:
928:
924:
920:
916:
912:
908:
901:
898:
893:
887:
879:
875:
870:
865:
861:
857:
853:
846:
844:
840:
827:
823:
819:
818:"Cimzia EPAR"
813:
811:
807:
794:
790:
784:
782:
778:
766:
762:
758:
752:
749:
742:
737:
733:
730:
729:
725:
720:
717:
716:
712:
708:
705:
704:
700:
698:
696:
695:TNF inhibitor
692:
689:
685:
676:
672:
667:
666:transmembrane
663:
658:
651:
646:
642:
638:
635:
634:
630:
626:
622:
619:
618:
614:
610:
607:
606:
602:
600:
598:
595:It is on the
593:
591:
587:
583:
579:
575:
571:
567:
563:
559:
555:
545:
538:
532:
521:
519:
515:
482:
480:
476:
471:
464:
463:ChEMBL1201831
460:
459:
457:
455:
451:
444:
440:
439:
437:
435:
431:
424:
420:
419:
417:
415:
411:
404:
403:
401:
399:
395:
388:
384:
383:
381:
379:
375:
368:
364:
363:
361:
359:
355:
350:
346:
342:
339:
337:
333:
330:about 11 days
329:
327:
320:
316:
312:
306: Rx-only
299:
296:
284:
281:
271:
270:
268:
266:
262:
257:
249:
244:
241:
240:
238:
236:
232:
229:
226:
224:
218:
212:
203:
202:
200:
198:
192:
185:
180:
171:
170:
168:
166:
162:
158:
154:
152:
148:
144:
140:
138:
134:
130:
126:
122:
118:
116:
112:
109:Clinical data
107:
104:
101:
99:
95:
91:
87:
84:
82:
78:
75:
74:Fab' fragment
72:
70:
66:
63:
59:
52:
47:
43:
38:
30:
19:
3740:Risankizumab
3725:Lebrikizumab
3705:Clazakizumab
3695:Anrukinzumab
3674:Tralokinumab
3590:Otelixizumab
3570:
3562:
3561:
3531:Tregalizumab
3516:Tislelizumab
3486:Satralizumab
3466:Rontalizumab
3461:Retifanlimab
3436:Plozalizumab
3416:Pateclizumab
3411:Pascolizumab
3406:Ozoralizumab
3356:Lampalizumab
3346:Inebilizumab
3336:Fontolizumab
3295:
3286:Camrelizumab
3281:Benralizumab
3276:Atezolizumab
3262:
3205:Clenoliximab
3106:
3090:Bertilimumab
3085:
3074:Tremelimumab
3054:
2977:Mavrilimumab
2967:Lirentelimab
2962:Lerdelimumab
2937:Fresolimumab
2877:Atorolimumab
2855:
2787:Upadacitinib
2747:Satralizumab
2732:Ritlecitinib
2727:Risankizumab
2522:
2503:
2443:Teprotumumab
2393:Inebilizumab
2388:Fontolizumab
2368:Atorolimumab
2336:T-lymphocyte
2334:
2308:
2292:
2278:
2259:
2248:Lerdelimumab
2243:Bertilimumab
2235:
2223:
2202:
2188:
2174:
2160:
2141:
2122:
2106:Pascolizumab
2091:Obinutuzumab
2083:
2069:
2055:
2039:Clenoliximab
2031:
2015:Otelixizumab
2002:
1975:
1962:Lebrikizumab
1946:
1930:
1914:
1898:
1882:
1839:Satralizumab
1829:Risankizumab
1761:
1737:
1720:
1704:
1696:Serum target
1648:Temsirolimus
1574:
1565:Pomalidomide
1560:Lenalidomide
1518:Pimecrolimus
1497:
1471:Methotrexate
1463:
1441:
1428:Azathioprine
1420:
1405:(initiation)
1302:
1298:
1288:
1269:
1265:
1255:
1245:November 15,
1243:. Retrieved
1239:the original
1229:
1220:
1216:
1209:
1200:
1196:
1195:(precise)".
1149:
1145:
1135:
1123:. Retrieved
1119:the original
1109:
1097:. Retrieved
1083:
1071:. Retrieved
1067:the original
1062:
1053:
1044:10665/371090
1034:
1025:
1013:. Retrieved
1004:
959:
955:
949:
914:
910:
900:
886:cite journal
859:
855:
832:November 15,
830:. Retrieved
797:. Retrieved
792:
768:. Retrieved
760:
751:
681:
603:Medical uses
594:
584:specific to
557:
553:
552:
541:
535:
323:Elimination
265:Legal status
259:Legal status
228:Subcutaneous
165:License data
29:
18:Certolizumab
3836:from market
3806:Lemalesomab
3801:Fanolesomab
3796:Besilesomab
3735:Perakizumab
3720:Mirikizumab
3710:Gevokizumab
3700:Bimekizumab
3679:Ustekinumab
3664:Secukinumab
3649:Fezakinumab
3644:Canakinumab
3639:Briakinumab
3614:Interleukin
3567:Dostarlimab
3546:Visilizumab
3541:Vedolizumab
3536:Vatelizumab
3526:Toralizumab
3521:Tocilizumab
3506:Teclistamab
3481:Samalizumab
3471:Rovelizumab
3451:Ravulizumab
3431:Pidilizumab
3426:Pexelizumab
3391:Ocrelizumab
3386:Natalizumab
3376:Mepolizumab
3366:Ligelizumab
3361:Letolizumab
3331:Etrolizumab
3321:Epratuzumab
3291:Cedelizumab
3245:Vapaliximab
3240:Teneliximab
3230:Lumiliximab
3215:Gomiliximab
3200:Basiliximab
3172:Vepalimomab
3157:Nerelimomab
3142:Gavilimomab
3137:Faralimomab
3132:Elsilimomab
3107:Combination
3100:Zanolimumab
3095:Ontamalimab
3043:Ulocuplumab
3038:Tezepelumab
3028:Sifalimumab
3008:Pamrevlumab
2987:Morolimumab
2982:Metelimumab
2952:Lanadelumab
2887:Avdoralimab
2872:Anifrolumab
2782:Tofacitinib
2722:Ravulizumab
2712:Pirfenidone
2702:Peficitinib
2602:Canakinumab
2592:Briakinumab
2582:Bimekizumab
2577:Baricitinib
2542:Aflibercept
2453:Vepalimomab
2448:Vapaliximab
2423:Rovelizumab
2413:Pexelizumab
2403:Morolimumab
2378:Cedelizumab
2363:Anifrolumab
2358:Alemtuzumab
2316:Basiliximab
2286:Tocilizumab
2272:Vedolizumab
2267:Natalizumab
2253:Metelimumab
2196:Gavilimomab
2154:Toralizumab
2149:Teneliximab
2135:Lumiliximab
2130:Gomiliximab
2116:Ublituximab
2096:Ocrelizumab
2049:Zanolimumab
2025:Visilizumab
1983:Secukinumab
1967:Ustekinumab
1938:Elsilimomab
1922:Faralimomab
1890:Mepolizumab
1874:Ustekinumab
1869:Tocilizumab
1844:Secukinumab
1794:Canakinumab
1784:Briakinumab
1779:Bimekizumab
1774:Basiliximab
1763:Interleukin
1753:Nerelimomab
1658:Zotarolimus
1599:(reception)
1570:Thalidomide
1528:Voclosporin
1513:Ciclosporin
1507:Calcineurin
1503:Cyclophilin
1450:Leflunomide
1446:inhibitors
1272:(3): A227.
770:October 22,
529: g·mol
367:428863-50-7
352:Identifiers
151:MedlinePlus
124:Other names
115:Trade names
3889:Categories
3766:Lokivetmab
3759:Veterinary
3745:Spesolimab
3730:Olokizumab
3715:Ixekizumab
3659:Guselkumab
3654:Fletikumab
3634:Brazikumab
3629:Bermekimab
3600:Sutimlimab
3574:Ibalizumab
3511:Teplizumab
3491:Siplizumab
3476:Ruplizumab
3456:Reslizumab
3446:Quilizumab
3401:Omalizumab
3351:Itolizumab
3341:Frexalimab
3316:Efalizumab
3311:Eculizumab
3306:Daclizumab
3271:Aselizumab
3266:Apolizumab
3235:Priliximab
3220:Infliximab
3162:Odulimomab
3152:Maslimomab
3147:Inolimomab
3127:Afelimomab
3064:Durvalumab
3059:Ipilimumab
3048:Varlilumab
3018:Relatlimab
3013:Placulumab
2957:Lenzilumab
2932:Emapalumab
2917:Cemiplimab
2902:Brodalumab
2897:Bleselumab
2867:Adalimumab
2772:Sutimlimab
2767:Spesolimab
2752:Siltuximab
2692:Olokizumab
2682:Ixekizumab
2677:Itacitinib
2667:Guselkumab
2662:Fingolimod
2657:Filgotinib
2607:Crovalimab
2597:Brodalumab
2587:Blisibimod
2552:Rilonacept
2535:Opinercept
2530:Etanercept
2516:Belatacept
2467:Polyclonal
2428:Siplizumab
2418:Reslizumab
2408:Ofatumumab
2398:Maslimomab
2383:Emapalumab
2326:Inolimomab
2321:Daclizumab
2300:Odulimomab
2215:Ruplizumab
2210:Frexalimab
2168:Aselizumab
2063:Efalizumab
2020:Teplizumab
1916:Interferon
1906:Omalizumab
1859:Spesolimab
1849:Siltuximab
1824:Rilonacept
1819:Olokizumab
1809:Ixekizumab
1804:Guselkumab
1799:Daclizumab
1789:Brodalumab
1748:Infliximab
1733:Afelimomab
1728:Adalimumab
1712:Eculizumab
1688:Monoclonal
1679:Antibodies
1653:Umirolimus
1633:Everolimus
1582:Apremilast
1542:Gusperimus
1523:Tacrolimus
1491:inhibitors
1483:Macrolides
1465:antifolate
1223:(4): A107.
1152:(1): 228.
1125:October 1,
743:References
662:homotrimer
518:Molar mass
423:UMD07X179E
398:ChemSpider
358:CAS Number
3846:Phase III
3834:Withdrawn
3811:Sulesomab
3688:Humanized
3669:Sirukumab
3501:Talizumab
3326:Erlizumab
3255:Humanized
3225:Keliximab
3210:Galiximab
3069:Nivolumab
3033:Tabalumab
3023:Sarilumab
2997:Oleclumab
2992:Namilumab
2972:Lirilumab
2947:Ianalumab
2942:Golimumab
2927:Eldelumab
2922:Dupilumab
2892:Belimumab
2862:Abrilumab
2762:Sirukumab
2757:Siponimod
2742:Sarilumab
2717:Ponesimod
2687:Netakimab
2672:Iptacopan
2652:Etrasimod
2612:Danicopan
2547:Alefacept
2511:Abatacept
2433:Talizumab
2373:Begelomab
2229:Belimumab
2182:Galiximab
2111:Rituximab
2077:Erlizumab
2044:Keliximab
1854:Sirukumab
1834:Sarilumab
1814:Netakimab
1743:Golimumab
1643:Sirolimus
1073:April 22,
688:PEGylated
336:Excretion
325:half-life
221:Routes of
195:Pregnancy
143:Monograph
137:Drugs.com
103:TNF alpha
86:Humanized
3879:Medicine
3187:Chimeric
3079:Urelumab
3002:Oxelumab
2912:Carlumab
2882:Avelumab
2831:for the
2697:Ozanimod
2572:Avacopan
2565:Unsorted
2351:Unsorted
2261:Integrin
1994:Cellular
1769:Anakinra
1615:Anakinra
1537:Abetimus
1389: /
1329:28884785
1178:28124979
1094:Medscape
1033:(2023).
1015:July 18,
984:21974683
976:15934837
941:20190560
878:17634458
826:Archived
799:July 18,
793:DailyMed
678:.
641:U.S. FDA
544:(verify)
378:DrugBank
235:ATC code
197:category
179:DailyMed
3781:lesions
3556:TGN1412
3441:PRO 140
2493:-cept (
1320:6483724
1169:5297857
932:2840232
711:placebo
560:, is a
479:Formula
387:DB08904
297:Rx-only
294:WARNING
251:)
245: (
243:L04AB05
210: C
181::
157:a608041
3865:Portal
3829:WHO-EM
3571:Other:
2505:CTLA-4
2495:Fusion
1996:target
1977:IL-17A
1954:, and
1487:other
1352:(MeSH)
1327:
1317:
1176:
1166:
1099:May 1,
982:
974:
939:
929:
876:
558:Cimzia
454:ChEMBL
443:D03441
341:Kidney
291:
278:
177:
127:CDP870
119:Cimzia
98:Target
88:(from
81:Source
3789:Mouse
3622:Human
3120:Mouse
3086:Other
2849:Human
2294:LFA-1
2204:CD154
2057:CD11a
1956:IL-23
1952:IL-13
1948:IL-12
1552:IMiDs
1009:(FDA)
1005:U.S.
980:S2CID
347:only)
90:mouse
2224:BLyS
2176:CD80
2143:CD40
2124:CD23
2085:CD20
2071:CD18
1932:IL-6
1625:mTOR
1499:FKBP
1489:IL-2
1325:PMID
1303:2017
1247:2009
1174:PMID
1127:2013
1101:2008
1075:2008
1017:2020
972:PMID
937:PMID
911:mAbs
892:link
874:PMID
834:2009
801:2020
772:2023
691:Fab'
675:5WUX
576:and
493:3252
487:2115
434:KEGG
414:UNII
405:none
317:data
133:AHFS
69:Type
2237:CAT
2033:CD4
2004:CD3
1722:TNF
1395:L04
1315:PMC
1307:doi
1274:doi
1221:130
1197:Gut
1164:PMC
1154:doi
1039:hdl
964:doi
927:PMC
919:doi
864:doi
860:357
765:FDA
671:PDB
590:UCB
527:.46
525:749
505:673
499:556
345:PEG
248:WHO
3891::
3842::
3565::
3109::
3088::
3057::
2860::
1950:,
1323:.
1313:.
1301:.
1297:.
1270:16
1268:.
1264:.
1219:.
1201:54
1199:.
1186:^
1172:.
1162:.
1150:18
1148:.
1144:.
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978:.
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925:.
913:.
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884:{{
872:.
858:.
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842:^
820:.
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780:^
763:.
759:.
673::
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572:,
568:,
523:47
511:16
302:EU
287:US
280:S4
274:AU
206:AU
174:US
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3004:§
2821:e
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2644:(
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