646:
40:
31:
3863:
620:(EMA) issued a positive opinion recommending that the European Commission grant a marketing authorisation for Cimzia for the treatment of rheumatoid arthritis only - the CHMP refused approval for the treatment of Crohn's disease. The marketing authorisation was granted to UCB Pharma SA in October 2009.
1183:
Schreiber S, Khaliq-Kareemi M, Lawrance I, Hanauer S, McColm J, Bloomfield R, et al. (2005). "Certolizumab pegol, a humanised anti-TNF pegylated FAb' fragment, is safe and effective in the maintenance of response and remission following induction in active Crohn's disease: a phase 3 study
1203:
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, McColm JA, et al. (2006). "Certolizumab pegol administered subcutaneously is effective and well tolerated in patients with active Crohn's disease: results from a 26-week, placebo-controlled Phase 3 study (PRECiSE 1)".
1251:"PMS50 – Rapid Improvements In Patient-Reported Outcomes With Certolizumab Pegol In Patients With Axial Spondyloarthritis, Including Ankylosing Spondylitis And Non-Radiographic Axial Spondyloarthritis: 24-Week Results Of A Phase 3 Double Blind Randomized Placebo-Controlled Study"
710:
In 2013, a phase 3 double blind randomized placebo-controlled study found significantly positive results in patient self-reported questionnaires, with rapid improvement of function and pain reduction, in patients with
1103:
268:
2808:
3903:
223:
525:
1107:
3913:
613:
1223:
121:
1366:
629:
2801:
57:
2282:
2794:
880:
814:
1131:"Molecular Basis for the Neutralization of Tumor Necrosis Factor α by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases"
3817:
1024:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
585:
604:(FDA) approved Cimzia for the treatment of Crohn's disease in people who did not respond sufficiently or adequately to standard therapy.
2225:
1595:
1047:
1359:
777:
2634:
253:
153:
172:
3908:
3789:
3853:
3799:
1431:
995:
653:
of TNF-alpha (tan). Certolizumab can block TNF in both its soluble form (freely circulating in the bloodstream) and its
601:
402:
645:
3898:
3893:
3834:
1540:
1352:
1227:
1104:"Cimzia (certolizumab pegol) approved by the U.S. FDA for treatment of adult patients with active psoriatic arthritis"
672:
574:
216:
1410:
1224:"New Analysis Shows Cimzia (Certolizumab Pegol) Maintained Remission and Response in Recent Onset Crohn's Disease"
3383:
2088:
1019:
810:
617:
2468:
1338:
698:
Positive results have been demonstrated in two phase III trials (PRECiSE 1 and 2) of certolizumab pegol versus
679:
989:
3888:
3822:
2463:
712:
209:
3883:
2268:
1694:
1375:
566:
451:
39:
746:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2895:
2817:
2455:
874:
3099:
1344:
745:
724:
558:
311:
1676:
633:
570:
562:
346:
69:
50:
1282:
Ruiz Garcia V, Burls A, Cabello JB, Vela
Casasempere P, Bort-Marti S, Bernal JA (September 2017).
3243:
3083:
2875:
2625:
968:
183:
2665:
2523:
554:
2675:
2361:
1802:
839:
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, et al. (July 2007).
3175:
2845:
2786:
2630:
2620:
1421:
1379:
1334:
1313:
1162:
960:
925:
862:
659:
550:
103:
806:
3165:
3155:
2426:
2329:
1992:
1888:
1303:
1295:
1262:
1152:
1142:
1027:
952:
915:
907:
852:
467:
355:
303:
62:
411:
3867:
3583:
3359:
2725:
2610:
131:
1055:
3828:
2615:
2483:
2131:
1965:
1944:
1940:
1936:
1564:
1401:
1308:
1283:
1157:
1130:
920:
895:
3877:
3738:
3539:
3484:
3409:
3369:
3289:
3183:
2829:
2821:
2765:
2695:
2605:
2512:
2298:
1998:
1920:
1872:
1852:
1710:
1626:
1477:
1443:
943:
Kaushik VV, Moots RJ (April 2005). "CDP-870 (certolizumab) in rheumatoid arthritis".
683:
654:
578:
281:
145:
972:
3728:
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3693:
3683:
3662:
3578:
3519:
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3424:
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2775:
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2431:
2381:
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2236:
2231:
2094:
2079:
2027:
2003:
1950:
1827:
1817:
1636:
1553:
1548:
1506:
1459:
1416:
1383:
1299:
1048:"Cimzia Approved in the US for the Treatment of Moderate to Severe Crohn's Disease"
236:
231:
22:
3794:
3784:
3723:
3708:
3698:
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3160:
3145:
3130:
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3120:
3088:
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3016:
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2700:
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2255:
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2123:
2118:
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2084:
2037:
2013:
1971:
1955:
1926:
1910:
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1857:
1832:
1782:
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1762:
1751:
1741:
1646:
1558:
1516:
1501:
1495:
1491:
1438:
1267:
1250:
139:
30:
778:"Cimzia- certolizumab pegol kit Cimzia- certolizumab pegol injection, solution"
3754:
3733:
3718:
3703:
3647:
3642:
3622:
3617:
3588:
3562:
3499:
3479:
3464:
3444:
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3389:
3339:
3329:
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3294:
3259:
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3208:
3150:
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3115:
3052:
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3036:
3006:
3001:
2945:
2920:
2905:
2890:
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2655:
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2540:
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2406:
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2314:
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2203:
2198:
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2150:
2051:
2008:
1904:
1894:
1847:
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1807:
1797:
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1787:
1777:
1736:
1721:
1716:
1700:
1641:
1621:
1570:
1530:
1511:
1453:
650:
506:
386:
1078:
956:
3657:
3489:
3314:
3213:
3198:
3057:
3021:
3011:
2985:
2980:
2960:
2935:
2930:
2915:
2910:
2880:
2850:
2750:
2745:
2730:
2705:
2660:
2640:
2600:
2535:
2499:
2421:
2217:
2170:
2099:
2065:
2032:
1842:
1822:
1731:
1631:
1471:
676:
324:
125:
91:
74:
1317:
1166:
964:
929:
911:
866:
3067:
2990:
2900:
2870:
2685:
2560:
2249:
1757:
1667:
1603:
1525:
1147:
1082:
857:
840:
366:
333:
167:
1032:
375:
3544:
3429:
2178:
699:
86:
663:
3769:
2493:
2324:
442:
329:
1249:
Sieper J, Tubergen A, Coteur G, Woltering F, Landewe R (May 2013).
984:
982:
431:
2192:
2045:
644:
78:
2164:
2112:
2073:
2059:
1613:
1487:
1284:"Certolizumab pegol (CDP870) for rheumatoid arthritis in adults"
990:"Drug Approval Package: Cimzia (Certolizumab Pegol) NDA #125160"
632:
approved Cimzia for the treatment of adult patients with active
422:
290:
2790:
1348:
275:
162:
2021:
753:
671:
Certolizumab pegol is a monoclonal antibody directed against
262:
194:
841:"Certolizumab pegol for the treatment of Crohn's disease"
1129:
Lee JU, Shin W, Son JY, Yoo KY, Heo YS (January 2017).
586:
532:
1226:(Press release). UCB. October 23, 2006. Archived from
3851:
3777:
3767:
3747:
3676:
3610:
3601:
3570:
3242:
3174:
3108:
2837:
2828:
2553:
2481:
2454:
2339:
1982:
1684:
1675:
1666:
1659:
1612:
1594:
1585:
1539:
1470:
1400:
1391:
505:
466:
461:
441:
421:
401:
385:
365:
345:
340:
323:
310:
302:
252:
247:
222:
208:
182:
152:
138:
120:
112:
102:
97:
85:
68:
56:
49:
772:
770:
354:
834:
832:
723:Certolizumab appears beneficial in those with
649:Three certolizumab molecules (blue) binding a
614:Committee for Medicinal Products for Human Use
3904:World Health Organization essential medicines
2802:
1360:
801:
799:
702:in moderate to severe active Crohn's disease.
657:form (bound to the membrane of a cell). From
8:
1178:
1176:
171:
21:
1288:The Cochrane Database of Systematic Reviews
1135:International Journal of Molecular Sciences
3774:
3607:
2834:
2809:
2795:
2787:
1681:
1672:
1663:
1591:
1397:
1367:
1353:
1345:
1079:"FDA Approvals: Patanase, Actonel, Cimzia"
38:
29:
1337:at the U.S. National Library of Medicine
1307:
1266:
1156:
1146:
1031:
919:
856:
410:
3858:
737:
374:
144:
872:
20:
3914:Disease-modifying antirheumatic drugs
1026:. Geneva: World Health Organization.
817:from the original on November 9, 2009
450:
130:
44:Syringe with 200mg Certolizumab pegol
7:
945:Expert Opinion on Biological Therapy
235:
845:The New England Journal of Medicine
430:
879:: CS1 maint: overridden setting (
14:
3861:
553:medication for the treatment of
484:
478:
577:(TNF-α) and is manufactured by
1300:10.1002/14651858.CD007649.pub4
496:
490:
472:
1:
1432:dihydroorotate dehydrogenase
996:Food and Drug Administration
602:Food and Drug Administration
600:On April 22, 2008, the U.S.
545:, sold under the brand name
1411:purine synthesis inhibitors
1268:10.1016/j.jval.2013.03.1150
894:Goel N, Stephens S (2010).
673:tumor necrosis factor alpha
628:On September 27, 2013, the
575:tumor necrosis factor alpha
3930:
1036:. WHO/MHP/HPS/EML/2023.02.
675:. More precisely, it is a
462:Chemical and physical data
3812:
1596:IL-1 receptor antagonists
1077:Waknine Y (May 1, 2008).
1020:World Health Organization
811:European Medicines Agency
618:European Medicines Agency
522:
37:
28:
2469:Anti-lymphocyte globulin
1339:Medical Subject Headings
957:10.1517/14712598.5.4.601
682:fragment of a humanized
569:. It is a fragment of a
2464:Anti-thymocyte globulin
1376:Immunosuppressive drugs
713:axial spondyloarthritis
707:Axial spondyloarthritis
2269:Interleukin-6 receptor
1695:Complement component 5
912:10.4161/mabs.2.2.11271
668:
612:On June 26, 2009, the
567:ankylosing spondylitis
3909:Monoclonal antibodies
2896:Camidanlumab tesirine
2818:Monoclonal antibodies
686:monoclonal antibody.
648:
3571:Chimeric + humanized
3100:Nivolumab/relatlimab
1148:10.3390/ijms18010228
1058:on February 18, 2012
896:"Certolizumab pegol"
858:10.1056/NEJMoa067594
813:. October 22, 2009.
725:rheumatoid arthritis
720:Rheumatoid arthritis
609:Rheumatoid arthritis
559:rheumatoid arthritis
1000:. December 24, 1999
634:psoriatic arthritis
625:Psoriatic arthritis
571:monoclonal antibody
563:psoriatic arthritis
271:(Prescription only)
51:Monoclonal antibody
25:
16:Pharmaceutical drug
3899:Belgian inventions
3894:Immunosuppressants
3839:Never to phase III
3285:Certolizumab pegol
3252:Immunosuppressive:
2626:Diroximel fumarate
2299:IL-2 receptor/CD25
1727:Certolizumab pegol
1380:Immunosuppressants
1335:certolizumab+pegol
1110:on October 1, 2013
669:
543:Certolizumab pegol
173:Certolizumab pegol
23:Certolizumab pegol
3849:
3848:
3808:
3807:
3763:
3762:
3597:
3596:
3552:Immune activation
3044:Immune activation
2846:Immunosuppression
2784:
2783:
2631:Efgartigimod alfa
2621:Dimethyl fumarate
2549:
2548:
2477:
2476:
2450:
2449:
1655:
1654:
1581:
1580:
1422:Mycophenolic acid
1230:on March 29, 2020
1052:UCB press release
551:biopharmaceutical
540:
539:
294:
279:
266:
198:
165:
3921:
3866:
3865:
3864:
3857:
3775:
3608:
3166:Zolimomab aritox
3156:Telimomab aritox
2835:
2811:
2804:
2797:
2788:
2427:Telimomab aritox
2330:Zolimomab aritox
2151:CD62L/L-selectin
1889:Immunoglobulin E
1682:
1673:
1664:
1592:
1398:
1369:
1362:
1355:
1346:
1322:
1321:
1311:
1279:
1273:
1272:
1270:
1246:
1240:
1239:
1237:
1235:
1220:
1214:
1213:
1206:Gastroenterology
1200:
1194:
1193:
1180:
1171:
1170:
1160:
1150:
1126:
1120:
1119:
1117:
1115:
1106:. Archived from
1100:
1094:
1093:
1091:
1089:
1074:
1068:
1067:
1065:
1063:
1054:. Archived from
1044:
1038:
1037:
1035:
1016:
1010:
1009:
1007:
1005:
986:
977:
976:
940:
934:
933:
923:
891:
885:
884:
878:
870:
860:
836:
827:
826:
824:
822:
803:
794:
793:
791:
789:
784:. April 24, 2020
774:
765:
764:
762:
760:
750:nctr-crs.fda.gov
742:
666:
641:Method of action
536:
535:
528:
517:
515:
498:
492:
486:
480:
474:
454:
434:
414:
378:
358:
315:
292:
289:
284:
277:
274:
264:
261:
239:
196:
193:
175:
164:
161:
148:
134:
42:
33:
26:
24:
3929:
3928:
3924:
3923:
3922:
3920:
3919:
3918:
3874:
3873:
3872:
3862:
3860:
3852:
3850:
3845:
3844:
3829:Clinical trials
3804:
3759:
3743:
3672:
3593:
3584:Rozanolixizumab
3572:
3566:
3558:
3547:
3360:Lulizumab pegol
3238:
3170:
3104:
2824:
2815:
2785:
2780:
2726:Rozanolixizumab
2611:Deucravacitinib
2545:
2473:
2446:
2335:
1984:
1978:
1686:
1651:
1608:
1587:
1577:
1535:
1475:
1466:
1402:Antimetabolites
1393:
1387:
1373:
1331:
1326:
1325:
1294:(9): CD007649.
1281:
1280:
1276:
1255:Value in Health
1248:
1247:
1243:
1233:
1231:
1222:
1221:
1217:
1202:
1201:
1197:
1192:(suppl 7): A82.
1182:
1181:
1174:
1128:
1127:
1123:
1113:
1111:
1102:
1101:
1097:
1087:
1085:
1076:
1075:
1071:
1061:
1059:
1046:
1045:
1041:
1018:
1017:
1013:
1003:
1001:
988:
987:
980:
942:
941:
937:
893:
892:
888:
871:
838:
837:
830:
820:
818:
805:
804:
797:
787:
785:
776:
775:
768:
758:
756:
744:
743:
739:
734:
695:Crohn's disease
692:
690:Clinical trials
658:
643:
597:Crohn's Disease
594:
555:Crohn's disease
531:
529:
526:(what is this?)
523:
513:
511:
501:
495:
489:
483:
477:
457:
437:
417:
397:
381:
361:
313:
304:Pharmacokinetic
298:
282:
243:
211:
204:
185:
178:
45:
17:
12:
11:
5:
3927:
3925:
3917:
3916:
3911:
3906:
3901:
3896:
3891:
3889:TNF inhibitors
3886:
3876:
3875:
3871:
3870:
3847:
3846:
3843:
3842:
3841:
3840:
3837:
3826:
3820:
3814:
3813:
3810:
3809:
3806:
3805:
3803:
3802:
3797:
3792:
3787:
3781:
3779:
3772:
3765:
3764:
3761:
3760:
3758:
3757:
3751:
3749:
3745:
3744:
3742:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3680:
3678:
3674:
3673:
3671:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3614:
3612:
3605:
3599:
3598:
3595:
3594:
3592:
3591:
3586:
3581:
3575:
3573:
3568:
3567:
3549:
3548:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3384:+hyaluronidase
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3248:
3246:
3240:
3239:
3237:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3180:
3178:
3172:
3171:
3169:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3112:
3110:
3106:
3105:
3103:
3102:
3092:
3091:
3086:
3081:
3071:
3070:
3065:
3060:
3055:
3050:
3040:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2988:
2983:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2841:
2839:
2832:
2826:
2825:
2816:
2814:
2813:
2806:
2799:
2791:
2782:
2781:
2779:
2778:
2773:
2768:
2763:
2758:
2753:
2748:
2743:
2738:
2733:
2728:
2723:
2718:
2713:
2708:
2703:
2698:
2693:
2688:
2683:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2638:
2635:+hyaluronidase
2628:
2623:
2618:
2616:Deuruxolitinib
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2557:
2555:
2551:
2550:
2547:
2546:
2544:
2543:
2538:
2533:
2528:
2527:
2526:
2521:
2509:
2508:
2507:
2502:
2489:
2487:
2479:
2478:
2475:
2474:
2472:
2471:
2466:
2460:
2458:
2452:
2451:
2448:
2447:
2445:
2444:
2439:
2434:
2429:
2424:
2419:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2343:
2341:
2337:
2336:
2334:
2333:
2320:
2319:
2318:
2317:
2312:
2307:
2294:
2293:
2292:
2291:
2279:
2278:
2277:
2265:
2264:
2263:
2258:
2246:
2245:
2244:
2239:
2234:
2222:
2221:
2220:
2209:
2208:
2207:
2206:
2201:
2189:
2188:
2187:
2175:
2174:
2173:
2161:
2160:
2159:
2147:
2146:
2145:
2140:
2128:
2127:
2126:
2121:
2109:
2108:
2107:
2102:
2097:
2092:
2089:+hyaluronidase
2082:
2070:
2069:
2068:
2056:
2055:
2054:
2042:
2041:
2040:
2035:
2030:
2018:
2017:
2016:
2011:
2006:
2001:
1988:
1986:
1980:
1979:
1977:
1976:
1975:
1974:
1961:
1960:
1959:
1958:
1953:
1932:
1931:
1930:
1929:
1916:
1915:
1914:
1913:
1900:
1899:
1898:
1897:
1884:
1883:
1882:
1881:
1868:
1867:
1866:
1865:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1747:
1746:
1745:
1744:
1739:
1734:
1729:
1724:
1719:
1706:
1705:
1704:
1703:
1690:
1688:
1679:
1670:
1661:
1657:
1656:
1653:
1652:
1650:
1649:
1644:
1639:
1634:
1629:
1624:
1618:
1616:
1610:
1609:
1607:
1606:
1600:
1598:
1589:
1583:
1582:
1579:
1578:
1576:
1575:
1574:
1573:
1565:PDE4 inhibitor
1561:
1556:
1551:
1545:
1543:
1537:
1536:
1534:
1533:
1528:
1522:
1521:
1520:
1519:
1514:
1509:
1504:
1483:
1481:
1468:
1467:
1465:
1464:
1463:
1462:
1449:
1448:
1447:
1446:
1441:
1427:
1426:
1425:
1424:
1419:
1406:
1404:
1395:
1389:
1388:
1374:
1372:
1371:
1364:
1357:
1349:
1343:
1342:
1330:
1329:External links
1327:
1324:
1323:
1274:
1241:
1215:
1195:
1172:
1121:
1095:
1069:
1039:
1011:
978:
951:(4): 601–606.
935:
906:(2): 137–147.
886:
851:(3): 228–238.
828:
795:
766:
736:
735:
733:
730:
729:
728:
721:
717:
716:
708:
704:
703:
696:
691:
688:
642:
639:
638:
637:
626:
622:
621:
616:(CHMP) of the
610:
606:
605:
598:
593:
590:
538:
537:
520:
519:
509:
503:
502:
499:
493:
487:
481:
475:
470:
464:
463:
459:
458:
456:
455:
447:
445:
439:
438:
436:
435:
427:
425:
419:
418:
416:
415:
407:
405:
399:
398:
396:
395:
391:
389:
383:
382:
380:
379:
371:
369:
363:
362:
360:
359:
351:
349:
343:
342:
338:
337:
327:
321:
320:
317:
308:
307:
300:
299:
297:
296:
287:
272:
258:
256:
250:
249:
245:
244:
242:
241:
228:
226:
220:
219:
214:
212:administration
206:
205:
203:
202:
200:
190:
188:
180:
179:
177:
176:
158:
156:
150:
149:
142:
136:
135:
128:
118:
117:
114:
110:
109:
106:
100:
99:
95:
94:
89:
83:
82:
72:
66:
65:
60:
54:
53:
47:
46:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
3926:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3884:Biotechnology
3882:
3881:
3879:
3869:
3859:
3855:
3838:
3836:
3833:
3832:
3830:
3827:
3824:
3821:
3819:
3816:
3815:
3811:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3782:
3780:
3776:
3773:
3771:
3768:Inflammatory
3766:
3756:
3753:
3752:
3750:
3746:
3740:
3739:Tildrakizumab
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3681:
3679:
3675:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3615:
3613:
3609:
3606:
3604:
3600:
3590:
3587:
3585:
3582:
3580:
3577:
3576:
3574:
3569:
3565:
3564:
3561:
3557:
3553:
3546:
3543:
3541:
3540:Vobarilizumab
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3485:Spartalizumab
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3410:Pembrolizumab
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3385:
3381:
3378:
3376:
3373:
3371:
3370:Mogamulizumab
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3290:Crizanlizumab
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3250:
3249:
3247:
3245:
3241:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3184:Andecaliximab
3182:
3181:
3179:
3177:
3173:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3113:
3111:
3107:
3101:
3097:
3094:
3093:
3090:
3087:
3085:
3082:
3080:
3076:
3073:
3072:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3045:
3042:
3041:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2848:
2847:
2843:
2842:
2840:
2836:
2833:
2831:
2830:Immune system
2827:
2823:
2822:immune system
2819:
2812:
2807:
2805:
2800:
2798:
2793:
2792:
2789:
2777:
2774:
2772:
2769:
2767:
2766:Tildrakizumab
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2734:
2732:
2729:
2727:
2724:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2702:
2699:
2697:
2696:Pegcetacoplan
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2636:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2606:Darvadstrocel
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2558:
2556:
2552:
2542:
2539:
2537:
2534:
2532:
2529:
2525:
2522:
2520:
2517:
2516:
2515:
2514:
2513:TNF inhibitor
2510:
2506:
2503:
2501:
2498:
2497:
2496:
2495:
2491:
2490:
2488:
2485:
2480:
2470:
2467:
2465:
2462:
2461:
2459:
2457:
2453:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2344:
2342:
2338:
2331:
2327:
2326:
2322:
2321:
2316:
2313:
2311:
2308:
2306:
2303:
2302:
2301:
2300:
2296:
2295:
2290:
2287:
2286:
2285:
2284:
2280:
2276:
2273:
2272:
2271:
2270:
2266:
2262:
2259:
2257:
2254:
2253:
2252:
2251:
2247:
2243:
2240:
2238:
2235:
2233:
2230:
2229:
2228:
2227:
2223:
2219:
2216:
2215:
2214:
2211:
2210:
2205:
2202:
2200:
2197:
2196:
2195:
2194:
2190:
2186:
2183:
2182:
2181:
2180:
2179:CD147/Basigin
2176:
2172:
2169:
2168:
2167:
2166:
2162:
2158:
2155:
2154:
2153:
2152:
2148:
2144:
2141:
2139:
2136:
2135:
2134:
2133:
2129:
2125:
2122:
2120:
2117:
2116:
2115:
2114:
2110:
2106:
2103:
2101:
2098:
2096:
2093:
2090:
2086:
2083:
2081:
2078:
2077:
2076:
2075:
2071:
2067:
2064:
2063:
2062:
2061:
2057:
2053:
2050:
2049:
2048:
2047:
2043:
2039:
2036:
2034:
2031:
2029:
2026:
2025:
2024:
2023:
2019:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1999:Muromonab-CD3
1997:
1996:
1995:
1994:
1990:
1989:
1987:
1981:
1973:
1970:
1969:
1968:
1967:
1963:
1962:
1957:
1954:
1952:
1949:
1948:
1947:
1946:
1942:
1938:
1934:
1933:
1928:
1925:
1924:
1923:
1922:
1918:
1917:
1912:
1909:
1908:
1907:
1906:
1902:
1901:
1896:
1893:
1892:
1891:
1890:
1886:
1885:
1880:
1877:
1876:
1875:
1874:
1873:Interleukin 5
1870:
1869:
1864:
1861:
1859:
1856:
1854:
1853:Tildrakizumab
1851:
1849:
1846:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1784:
1781:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1755:
1754:
1753:
1749:
1748:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1714:
1713:
1712:
1708:
1707:
1702:
1699:
1698:
1697:
1696:
1692:
1691:
1689:
1687:(noncellular)
1683:
1680:
1678:
1674:
1671:
1669:
1665:
1662:
1660:Extracellular
1658:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1627:Ridaforolimus
1625:
1623:
1620:
1619:
1617:
1615:
1611:
1605:
1602:
1601:
1599:
1597:
1593:
1590:
1586:Intracellular
1584:
1572:
1569:
1568:
1567:
1566:
1562:
1560:
1557:
1555:
1552:
1550:
1547:
1546:
1544:
1542:
1538:
1532:
1529:
1527:
1524:
1523:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1499:
1498:
1497:
1493:
1489:
1485:
1484:
1482:
1479:
1473:
1469:
1461:
1458:
1457:
1456:
1455:
1451:
1450:
1445:
1444:Teriflunomide
1442:
1440:
1437:
1436:
1434:
1433:
1429:
1428:
1423:
1420:
1418:
1415:
1414:
1413:
1412:
1408:
1407:
1405:
1403:
1399:
1396:
1392:Intracellular
1390:
1385:
1381:
1377:
1370:
1365:
1363:
1358:
1356:
1351:
1350:
1347:
1340:
1336:
1333:
1332:
1328:
1319:
1315:
1310:
1305:
1301:
1297:
1293:
1289:
1285:
1278:
1275:
1269:
1264:
1260:
1256:
1252:
1245:
1242:
1229:
1225:
1219:
1216:
1211:
1207:
1199:
1196:
1191:
1187:
1179:
1177:
1173:
1168:
1164:
1159:
1154:
1149:
1144:
1140:
1136:
1132:
1125:
1122:
1109:
1105:
1099:
1096:
1084:
1080:
1073:
1070:
1057:
1053:
1049:
1043:
1040:
1034:
1029:
1025:
1021:
1015:
1012:
999:
997:
991:
985:
983:
979:
974:
970:
966:
962:
958:
954:
950:
946:
939:
936:
931:
927:
922:
917:
913:
909:
905:
901:
897:
890:
887:
882:
876:
868:
864:
859:
854:
850:
846:
842:
835:
833:
829:
816:
812:
808:
807:"Cimzia EPAR"
802:
800:
796:
783:
779:
773:
771:
767:
755:
751:
747:
741:
738:
731:
726:
722:
719:
718:
714:
709:
706:
705:
701:
697:
694:
693:
689:
687:
685:
684:TNF inhibitor
681:
678:
674:
665:
661:
656:
655:transmembrane
652:
647:
640:
635:
631:
627:
624:
623:
619:
615:
611:
608:
607:
603:
599:
596:
595:
591:
589:
587:
584:It is on the
582:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
534:
527:
521:
510:
508:
504:
471:
469:
465:
460:
453:
452:ChEMBL1201831
449:
448:
446:
444:
440:
433:
429:
428:
426:
424:
420:
413:
409:
408:
406:
404:
400:
393:
392:
390:
388:
384:
377:
373:
372:
370:
368:
364:
357:
353:
352:
350:
348:
344:
339:
335:
331:
328:
326:
322:
319:about 11 days
318:
316:
309:
305:
301:
295: Rx-only
288:
285:
273:
270:
260:
259:
257:
255:
251:
246:
238:
233:
230:
229:
227:
225:
221:
218:
215:
213:
207:
201:
192:
191:
189:
187:
181:
174:
169:
160:
159:
157:
155:
151:
147:
143:
141:
137:
133:
129:
127:
123:
119:
115:
111:
107:
105:
101:
98:Clinical data
96:
93:
90:
88:
84:
80:
76:
73:
71:
67:
64:
63:Fab' fragment
61:
59:
55:
52:
48:
41:
36:
32:
27:
19:
3729:Risankizumab
3714:Lebrikizumab
3694:Clazakizumab
3684:Anrukinzumab
3663:Tralokinumab
3579:Otelixizumab
3559:
3551:
3550:
3520:Tregalizumab
3505:Tislelizumab
3475:Satralizumab
3455:Rontalizumab
3450:Retifanlimab
3425:Plozalizumab
3405:Pateclizumab
3400:Pascolizumab
3395:Ozoralizumab
3345:Lampalizumab
3335:Inebilizumab
3325:Fontolizumab
3284:
3275:Camrelizumab
3270:Benralizumab
3265:Atezolizumab
3251:
3194:Clenoliximab
3095:
3079:Bertilimumab
3074:
3063:Tremelimumab
3043:
2966:Mavrilimumab
2956:Lirentelimab
2951:Lerdelimumab
2926:Fresolimumab
2866:Atorolimumab
2844:
2776:Upadacitinib
2736:Satralizumab
2721:Ritlecitinib
2716:Risankizumab
2511:
2492:
2432:Teprotumumab
2382:Inebilizumab
2377:Fontolizumab
2357:Atorolimumab
2325:T-lymphocyte
2323:
2297:
2281:
2267:
2248:
2237:Lerdelimumab
2232:Bertilimumab
2224:
2212:
2191:
2177:
2163:
2149:
2130:
2111:
2095:Pascolizumab
2080:Obinutuzumab
2072:
2058:
2044:
2028:Clenoliximab
2020:
2004:Otelixizumab
1991:
1964:
1951:Lebrikizumab
1935:
1919:
1903:
1887:
1871:
1828:Satralizumab
1818:Risankizumab
1750:
1726:
1709:
1693:
1685:Serum target
1637:Temsirolimus
1563:
1554:Pomalidomide
1549:Lenalidomide
1507:Pimecrolimus
1486:
1460:Methotrexate
1452:
1430:
1417:Azathioprine
1409:
1394:(initiation)
1291:
1287:
1277:
1258:
1254:
1244:
1234:November 15,
1232:. Retrieved
1228:the original
1218:
1209:
1205:
1198:
1189:
1185:
1184:(precise)".
1138:
1134:
1124:
1112:. Retrieved
1108:the original
1098:
1086:. Retrieved
1072:
1060:. Retrieved
1056:the original
1051:
1042:
1033:10665/371090
1023:
1014:
1002:. Retrieved
993:
948:
944:
938:
903:
899:
889:
875:cite journal
848:
844:
821:November 15,
819:. Retrieved
786:. Retrieved
781:
757:. Retrieved
749:
740:
670:
592:Medical uses
583:
573:specific to
546:
542:
541:
530:
524:
312:Elimination
254:Legal status
248:Legal status
217:Subcutaneous
154:License data
18:
3825:from market
3795:Lemalesomab
3790:Fanolesomab
3785:Besilesomab
3724:Perakizumab
3709:Mirikizumab
3699:Gevokizumab
3689:Bimekizumab
3668:Ustekinumab
3653:Secukinumab
3638:Fezakinumab
3633:Canakinumab
3628:Briakinumab
3603:Interleukin
3556:Dostarlimab
3535:Visilizumab
3530:Vedolizumab
3525:Vatelizumab
3515:Toralizumab
3510:Tocilizumab
3495:Teclistamab
3470:Samalizumab
3460:Rovelizumab
3440:Ravulizumab
3420:Pidilizumab
3415:Pexelizumab
3380:Ocrelizumab
3375:Natalizumab
3365:Mepolizumab
3355:Ligelizumab
3350:Letolizumab
3320:Etrolizumab
3310:Epratuzumab
3280:Cedelizumab
3234:Vapaliximab
3229:Teneliximab
3219:Lumiliximab
3204:Gomiliximab
3189:Basiliximab
3161:Vepalimomab
3146:Nerelimomab
3131:Gavilimomab
3126:Faralimomab
3121:Elsilimomab
3096:Combination
3089:Zanolimumab
3084:Ontamalimab
3032:Ulocuplumab
3027:Tezepelumab
3017:Sifalimumab
2997:Pamrevlumab
2976:Morolimumab
2971:Metelimumab
2941:Lanadelumab
2876:Avdoralimab
2861:Anifrolumab
2771:Tofacitinib
2711:Ravulizumab
2701:Pirfenidone
2691:Peficitinib
2591:Canakinumab
2581:Briakinumab
2571:Bimekizumab
2566:Baricitinib
2531:Aflibercept
2442:Vepalimomab
2437:Vapaliximab
2412:Rovelizumab
2402:Pexelizumab
2392:Morolimumab
2367:Cedelizumab
2352:Anifrolumab
2347:Alemtuzumab
2305:Basiliximab
2275:Tocilizumab
2261:Vedolizumab
2256:Natalizumab
2242:Metelimumab
2185:Gavilimomab
2143:Toralizumab
2138:Teneliximab
2124:Lumiliximab
2119:Gomiliximab
2105:Ublituximab
2085:Ocrelizumab
2038:Zanolimumab
2014:Visilizumab
1972:Secukinumab
1956:Ustekinumab
1927:Elsilimomab
1911:Faralimomab
1879:Mepolizumab
1863:Ustekinumab
1858:Tocilizumab
1833:Secukinumab
1783:Canakinumab
1773:Briakinumab
1768:Bimekizumab
1763:Basiliximab
1752:Interleukin
1742:Nerelimomab
1647:Zotarolimus
1588:(reception)
1559:Thalidomide
1517:Voclosporin
1502:Ciclosporin
1496:Calcineurin
1492:Cyclophilin
1439:Leflunomide
1435:inhibitors
1261:(3): A227.
759:October 22,
518: g·mol
356:428863-50-7
341:Identifiers
140:MedlinePlus
113:Other names
104:Trade names
3878:Categories
3755:Lokivetmab
3748:Veterinary
3734:Spesolimab
3719:Olokizumab
3704:Ixekizumab
3648:Guselkumab
3643:Fletikumab
3623:Brazikumab
3618:Bermekimab
3589:Sutimlimab
3563:Ibalizumab
3500:Teplizumab
3480:Siplizumab
3465:Ruplizumab
3445:Reslizumab
3435:Quilizumab
3390:Omalizumab
3340:Itolizumab
3330:Frexalimab
3305:Efalizumab
3300:Eculizumab
3295:Daclizumab
3260:Aselizumab
3255:Apolizumab
3224:Priliximab
3209:Infliximab
3151:Odulimomab
3141:Maslimomab
3136:Inolimomab
3116:Afelimomab
3053:Durvalumab
3048:Ipilimumab
3037:Varlilumab
3007:Relatlimab
3002:Placulumab
2946:Lenzilumab
2921:Emapalumab
2906:Cemiplimab
2891:Brodalumab
2886:Bleselumab
2856:Adalimumab
2761:Sutimlimab
2756:Spesolimab
2741:Siltuximab
2681:Olokizumab
2671:Ixekizumab
2666:Itacitinib
2656:Guselkumab
2651:Fingolimod
2646:Filgotinib
2596:Crovalimab
2586:Brodalumab
2576:Blisibimod
2541:Rilonacept
2524:Opinercept
2519:Etanercept
2505:Belatacept
2456:Polyclonal
2417:Siplizumab
2407:Reslizumab
2397:Ofatumumab
2387:Maslimomab
2372:Emapalumab
2315:Inolimomab
2310:Daclizumab
2289:Odulimomab
2204:Ruplizumab
2199:Frexalimab
2157:Aselizumab
2052:Efalizumab
2009:Teplizumab
1905:Interferon
1895:Omalizumab
1848:Spesolimab
1838:Siltuximab
1813:Rilonacept
1808:Olokizumab
1798:Ixekizumab
1793:Guselkumab
1788:Daclizumab
1778:Brodalumab
1737:Infliximab
1722:Afelimomab
1717:Adalimumab
1701:Eculizumab
1677:Monoclonal
1668:Antibodies
1642:Umirolimus
1622:Everolimus
1571:Apremilast
1531:Gusperimus
1512:Tacrolimus
1480:inhibitors
1472:Macrolides
1454:antifolate
1212:(4): A107.
1141:(1): 228.
1114:October 1,
732:References
651:homotrimer
507:Molar mass
412:UMD07X179E
387:ChemSpider
347:CAS Number
3835:Phase III
3823:Withdrawn
3800:Sulesomab
3677:Humanized
3658:Sirukumab
3490:Talizumab
3315:Erlizumab
3244:Humanized
3214:Keliximab
3199:Galiximab
3058:Nivolumab
3022:Tabalumab
3012:Sarilumab
2986:Oleclumab
2981:Namilumab
2961:Lirilumab
2936:Ianalumab
2931:Golimumab
2916:Eldelumab
2911:Dupilumab
2881:Belimumab
2851:Abrilumab
2751:Sirukumab
2746:Siponimod
2731:Sarilumab
2706:Ponesimod
2676:Netakimab
2661:Iptacopan
2641:Etrasimod
2601:Danicopan
2536:Alefacept
2500:Abatacept
2422:Talizumab
2362:Begelomab
2218:Belimumab
2171:Galiximab
2100:Rituximab
2066:Erlizumab
2033:Keliximab
1843:Sirukumab
1823:Sarilumab
1803:Netakimab
1732:Golimumab
1632:Sirolimus
1062:April 22,
677:PEGylated
325:Excretion
314:half-life
210:Routes of
184:Pregnancy
132:Monograph
126:Drugs.com
92:TNF alpha
75:Humanized
3868:Medicine
3176:Chimeric
3068:Urelumab
2991:Oxelumab
2901:Carlumab
2871:Avelumab
2820:for the
2686:Ozanimod
2561:Avacopan
2554:Unsorted
2340:Unsorted
2250:Integrin
1983:Cellular
1758:Anakinra
1604:Anakinra
1526:Abetimus
1378: /
1318:28884785
1167:28124979
1083:Medscape
1022:(2023).
1004:July 18,
973:21974683
965:15934837
930:20190560
867:17634458
815:Archived
788:July 18,
782:DailyMed
667:.
630:U.S. FDA
533:(verify)
367:DrugBank
224:ATC code
186:category
168:DailyMed
3770:lesions
3545:TGN1412
3430:PRO 140
2482:-cept (
1309:6483724
1158:5297857
921:2840232
700:placebo
549:, is a
468:Formula
376:DB08904
286:Rx-only
283:WARNING
240:)
234: (
232:L04AB05
199: C
170::
146:a608041
3854:Portal
3818:WHO-EM
3560:Other:
2494:CTLA-4
2484:Fusion
1985:target
1966:IL-17A
1943:, and
1476:other
1341:(MeSH)
1316:
1306:
1165:
1155:
1088:May 1,
971:
963:
928:
918:
865:
547:Cimzia
443:ChEMBL
432:D03441
330:Kidney
280:
267:
166:
116:CDP870
108:Cimzia
87:Target
77:(from
70:Source
3778:Mouse
3611:Human
3109:Mouse
3075:Other
2838:Human
2283:LFA-1
2193:CD154
2046:CD11a
1945:IL-23
1941:IL-13
1937:IL-12
1541:IMiDs
998:(FDA)
994:U.S.
969:S2CID
336:only)
79:mouse
2213:BLyS
2165:CD80
2132:CD40
2113:CD23
2074:CD20
2060:CD18
1921:IL-6
1614:mTOR
1488:FKBP
1478:IL-2
1314:PMID
1292:2017
1236:2009
1163:PMID
1116:2013
1090:2008
1064:2008
1006:2020
961:PMID
926:PMID
900:mAbs
881:link
863:PMID
823:2009
790:2020
761:2023
680:Fab'
664:5WUX
565:and
482:3252
476:2115
423:KEGG
403:UNII
394:none
306:data
122:AHFS
58:Type
2226:CAT
2022:CD4
1993:CD3
1711:TNF
1384:L04
1304:PMC
1296:doi
1263:doi
1210:130
1186:Gut
1153:PMC
1143:doi
1028:hdl
953:doi
916:PMC
908:doi
853:doi
849:357
754:FDA
660:PDB
579:UCB
516:.46
514:749
494:673
488:556
334:PEG
237:WHO
3880::
3831::
3554::
3098::
3077::
3046::
2849::
1939:,
1312:.
1302:.
1290:.
1286:.
1259:16
1257:.
1253:.
1208:.
1190:54
1188:.
1175:^
1161:.
1151:.
1139:18
1137:.
1133:.
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1050:.
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967:.
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924:.
914:.
902:.
898:.
877:}}
873:{{
861:.
847:.
843:.
831:^
809:.
798:^
780:.
769:^
752:.
748:.
662::
588:.
581:.
561:,
557:,
512:47
500:16
291:EU
276:US
269:S4
263:AU
195:AU
163:US
3856::
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3382:(
2993:§
2810:e
2803:t
2796:v
2637:)
2633:(
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2328:(
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1490:/
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1271:.
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1145::
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636:.
497:S
491:O
485:N
479:H
473:C
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81:)
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