1987:
and putamen, but not the medial preoptic nucleus. Next, the induction of c-Fos, a downstream (repressed) target of DeltaFosB, was measured in sexually experienced and naive animals. The number of mating-induced c-Fos-IR cells was significantly decreased in sexually experienced animals compared to sexually naive controls. Finally, DeltaFosB levels and its activity in the NAc were manipulated using viral-mediated gene transfer to study its potential role in mediating sexual experience and experience-induced facilitation of sexual performance. Animals with DeltaFosB overexpression displayed enhanced facilitation of sexual performance with sexual experience relative to controls. In contrast, the expression of DeltaJunD, a dominant-negative binding partner of DeltaFosB, attenuated sexual experience-induced facilitation of sexual performance, and stunted long-term maintenance of facilitation compared to DeltaFosB overexpressing group. Together, these findings support a critical role for DeltaFosB expression in the NAc in the reinforcing effects of sexual behavior and sexual experience-induced facilitation of sexual performance. ... both drug addiction and sexual addiction represent pathological forms of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry.
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that define a state of addiction. ... A large body of literature has demonstrated that such ΔFosB induction in D1-type neurons increases an animal's sensitivity to drug as well as natural rewards and promotes drug self-administration, presumably through a process of positive reinforcement ... Another ΔFosB target is cFos: as ΔFosB accumulates with repeated drug exposure it represses c-Fos and contributes to the molecular switch whereby ΔFosB is selectively induced in the chronic drug-treated state.. ... Moreover, there is increasing evidence that, despite a range of genetic risks for addiction across the population, exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict.
985:, and use that persists even if the user is aware of severe adverse consequences. For some people, addiction becomes chronic, with periodic relapses even after long periods of abstinence. As a chronic, relapsing disease, addiction may require continued treatments to increase the intervals between relapses and diminish their intensity. While some with substance issues recover and lead fulfilling lives, others require ongoing additional support. The ultimate goal of addiction treatment is to enable an individual to manage their substance misuse; for some this may mean abstinence. Immediate goals are often to reduce substance abuse, improve the patient's ability to function, and minimize the medical and social complications of substance abuse and their addiction; this is called "
1934:ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states.
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and the needs of the addicted person, and also need to locate the defects of their ego and defense mechanisms. Using this approach alone has proven to be ineffective in solving addiction problems. Cognitive and behavioral techniques should be integrated with psychodynamic approaches to achieve effective treatment for substance related disorders. Cognitive treatment requires psychologists to think deeply about what is happening in the brain of an addicted person. Cognitive psychologists should zoom in to neural functions of the brain and understand that drugs have been manipulating the dopamine reward center of the brain. From this particular state of thinking, cognitive psychologists need to find ways to change the thought process of the addicted person.
373:
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common mechanism of reward tolerance and dependence shared by several classes of drugs of abuse. Research since that time, by many laboratories, has provided substantial support for these hypotheses. Specifically, opiates in several CNS regions including NAc, and cocaine more selectively in NAc induce expression of certain adenylyl cyclase isoforms and PKA subunits via the transcription factor, CREB, and these transcriptional adaptations serve a homeostatic function to oppose drug action. In certain brain regions, such as locus coeruleus, these adaptations mediate aspects of physical opiate dependence and withdrawal, whereas in NAc they mediate reward tolerance and dependence that drives increased drug self-administration.
2052:; Henderson, A.S.; Strotzka, H.; Lipowski, Z.; Yu-cun, Shen; You-xin, Xu; Strömgren, E.; Glatzel, J.; Kühne, G.-E.; Misès, R.; Soldatos, C.R.; Pull, C.B.; Giel, R.; Jegede, R.; Malt, U.; Nadzharov, R.A.; Smulevitch, A.B.; Hagberg, B.; Perris, C.; Scharfetter, C.; Clare, A.; Cooper, J.E.; Corbett, J.A.; Griffith Edwards, J.; Gelder, M.; Goldberg, D.; Gossop, M.; Graham, P.; Kendell, R.E.; Marks, I.; Russell, G.; Rutter, M.; Shepherd, M.; West, D.J.; Wing, J.; Wing, L.; Neki, J.S.; Benson, F.; Cantwell, D.; Guze, S.; Helzer, J.; Holzman, P.; Kleinman, A.; Kupfer, D.J.; Mezzich, J.; Spitzer, R.; Lokar, J.
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observed to produce an elevation of extracellular glutamate, an increase in NMDA receptor subunits NR1 and NR2A, phosphorylated CaMKII, and c-fos. Expression of CaMKII and c-fos is attenuated by NMDA receptor antagonists, which is associated with blunted withdrawal in adult rats, but not neonatal rats While acute administration of opioids decreases AMPA receptor expression and depresses both NMDA and non-NMDA excitatory postsynaptic potentials in the NAC, withdrawal involves a lowered threshold for LTP and an increase in spontaneous firing in the NAc.
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patients. Most will have steps in place to handle severe withdrawal symptoms, either through behavioral therapy or other medications. Biological intervention should be combined with behavioral therapy approaches and other non-pharmacological techniques. Group therapies including anonymity, teamwork and sharing concerns of daily life among people who also have substance dependence issues can have a great impact on outcomes. However, these programs proved to be more effective and influential on persons who did not reach levels of serious dependence.
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legislations and agencies like the
Federal Bureau of Narcotics (FBN) mid-20th century in response to the nation's growing substance abuse issue. These strict punishments for drug offenses shined light on the fact that drug abuse was a multi-faceted problem. The President's Advisory Commission on Narcotics and Drug Abuse of 1963 addressed the need for a medical solution to drug abuse. However, drug abuse continued to be enforced by the federal government through agencies such as the DEA and further legislations such as The
1858:, which occurs when drug taking stops. Dependence from long-term drug use may have both a somatic component, manifested by physical symptoms, and an emotional–motivation component, manifested by dysphoria. While physical dependence and withdrawal occur with some drugs of abuse (opiates, ethanol), these phenomena are not useful in the diagnosis of addiction because they do not occur with other drugs of abuse (cocaine, amphetamine) and can occur with many drugs that are not abused (propranolol, clonidine).
1013:. These kinds of outcomes can be achieved without eliminating drug use completely. Drug treatment programs in Europe often report more favorable outcomes than those in the US because the criteria for measuring success are functional rather than abstinence-based. The supporters of programs with total abstinence from drugs as a goal believe that enabling further drug use means prolonged drug use and risks an increase in addiction and complications from addiction.
1399:, and it was further hypothesized that this might potentially be able to cure opium addiction. However, many people did become addicted to morphine. In particular, addiction to opium became widespread among soldiers fighting in the Civil War, who very often required painkillers and thus were very often prescribed morphine. Women were also very frequently prescribed opiates, and opiates were advertised as being able to relieve "female troubles".
1128:– which is the gold standard for treatment of opioid dependence in developed countries, reducing the risk and cost to both user and society more effectively than any other treatment modality (for opioid dependence), and shows the best short-term and long-term gains for the user, with the greatest longevity, least risk of fatality, greatest quality of life, and lowest risk of relapse and legal issues including arrest and incarceration.
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3689:| Living Hero Radio Show and Podcast special. With Dimitri Mobengo Mugianis, Bovenga Na Muduma, Clare S. Wilkins, Brad Burge, Tom Kingsley Brown, Susan Thesenga, Bruce K. Alexander, PhD ~ the voices of ex-addicts, researchers from The Multidisciplinary Association for Psychedelic Studies and Ibogaine/Iboga/Ayahuasca treatment providers sharing their experiences in breaking addiction with native medicines. January 2013
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dependence are more complex, with treatment aims including reduction in use to the point that drug use no longer interferes with normal activities such as work and family commitments; shifting the addict away from more dangerous routes of drug administration such as injecting to safer routes such as oral administration; reduction in crime committed by drug addicts; and treatment of other comorbid conditions such as
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1026:, an approach that looks at the relationship between thoughts, feelings and behaviors, addressing the root cause of maladaptive behavior. Cognitive-behavioral therapy treats addiction as a behavior rather than a disease, and so is subsequently curable, or rather, unlearnable. Cognitive-behavioral therapy programs recognize that, for some individuals, controlled use is a more realistic possibility.
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phenomena. Second, the term substance dependence implies that dependence is the primary pharmacologic phenomenon underlying addiction, which is likely not true, as tolerance, sensitization, and learning and memory also play central roles. It is ironic and unfortunate that the Manual avoids use of the term addiction, which provides the best description of the clinical syndrome.
1421:(NSDUH) reports on substance dependence/abuse rates in various population demographics across the U.S. When surveying populations based on race and ethnicity in those ages 12 and older, it was observed that American Indian/Alaskan Natives were among the highest rates and Asians were among the lowest rates in comparison to other racial/ethnic groups.
2153:"Diagnostic and Statistical Manual of Mental Disorders: DSM-5 (5th edition)2014 102 Diagnostic and Statistical Manual of Mental Disorders: DSM-5 (5th edition) Washington, DC American Psychiatric Association 2013 xliv+947 pp. 9780890425541(hbck);9780890425558(pbck) ÂŁ175 $ 199 (hbck); ÂŁ45 $ 69 (pbck)".
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In the past decade, there have been growing efforts through state and local legislations to shift from criminalizing drug abuse to treating it as a health condition requiring medical intervention. 28 states currently allow for the establishment of needle exchanges. Florida, Iowa, Missouri and
Arizona
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Alcohol dependence or abuse rates were shown to have no correspondence with any person's education level when populations were surveyed in varying degrees of education from ages 26 and older. However, when it came to illicit drug use there was a correlation, in which those that graduated from college
1416:
Internationally, the U.S. and
Eastern Europe contain the countries with the highest substance abuse disorder occurrence (5-6%). Africa, Asia, and the Middle East contain countries with the lowest worldwide occurrence (1-2%). Across the globe, those that tended to have a higher prevalence of substance
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was isolated in the early 19th century, and came to be prescribed commonly by doctors, both as a painkiller and as an intended cure for opium addiction. At the time, the prevailing medical opinion was that the addiction process occurred in the stomach, and thus it was hypothesized that patients would
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to pair unpleasant effects with the thought of alcohol use. Psychologists tend to use an integration of all these approaches to produce reliable and effective treatment. With the advanced clinical use of medications, biological treatment is now considered to be one of the most efficient interventions
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strategies. In addition, the same author suggests that social skills training adjunctive to inpatient treatment of alcohol dependence is probably efficacious. Community reinforcement has both efficacy and effectiveness data. In addition, behavioral treatment such as community reinforcement and family
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or other drugs despite problems related to use of the substance, substance dependence may be diagnosed. Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped. This, along with
Substance Abuse are considered Substance Use
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Addiction: A term used to indicate the most severe, chronic stage of substance-use disorder, in which there is a substantial loss of self-control, as indicated by compulsive drug taking despite the desire to stop taking the drug. In the DSM-5, the term addiction is synonymous with the classification
2301:
Substance-use disorder: A diagnostic term in the fifth edition of the
Diagnostic and Statistical Manual of Mental Disorders (DSM-5) referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems, disability, and failure to
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all introduced bills to allow for the establishment of needle exchanges in 2019. These bills have grown in popularity across party lines since needle exchanges were first introduced in
Amsterdam in 1983. In addition, AB-186 Controlled substances: overdose prevention program was introduced to operate
1713:
The United States' approach to substance abuse has shifted over the last decade, and is continuing to change. The federal government was minimally involved in the 19th century. The federal government transitioned from using taxation of drugs in the early 20th century to criminalizing drug abuse with
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under the control of licensing systems. Typically this legislation covers any or all of the opiates, amphetamines, cannabinoids, cocaine, barbiturates, benzodiazepines, anesthetics, hallucinogenics, derivatives and a variety of more modern synthetic drugs. Unlicensed production, supply or possession
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and group counseling. Frequently, a physician or psychiatrist will prescribe medications in order to help patients cope with the side effects of their addiction. Medications can help immensely with anxiety and insomnia, can treat underlying mental disorders (cf. self-medication hypothesis, Khantzian
1986:
It has been found that deltaFosB gene in the NAc is critical for reinforcing effects of sexual reward. Pitchers and colleagues (2010) reported that sexual experience was shown to cause DeltaFosB accumulation in several limbic brain regions including the NAc, medial pre-frontal cortex, VTA, caudate,
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Although the legislation may be justifiable on moral or public health grounds, it can make addiction or dependency a much more serious issue for the individual: reliable supplies of a drug become difficult to secure, and the individual becomes vulnerable to both criminal abuse and legal punishment.
1402:
Many soldiers in the
Vietnam War were introduced to heroin and developed a dependency on the substance which survived even when they returned to the US. Technological advances in travel meant that this increased demand for heroin in the US could now be met. Furthermore, as technology advanced, more
1000:
Treatments and attitudes toward addiction vary widely among different countries. In the US and developing countries, the goal of commissioners of treatment for drug dependence is generally total abstinence from all drugs. Other countries, particularly in Europe, argue the aims of treatment for drug
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Medical professionals need to apply many techniques and approaches to help patients with substance related disorders. Using a psychodynamic approach is one of the techniques that psychologists use to solve addiction problems. In psychodynamic therapy, psychologists need to understand the conflicts
1103:
for opioid detoxification, for first-time users or those who wish to attempt an abstinence-based recovery (90% of opioid users relapse to active addiction within eight months or are multiple relapse patients); or replacing an opioid that is interfering with or destructive to a user's life, such as
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Despite the importance of numerous psychosocial factors, at its core, drug addiction involves a biological process: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use,
1131:
In a survey of treatment providers from three separate institutions, the
National Association of Alcoholism and Drug Abuse Counselors, Rational Recovery Systems and the Society of Psychologists in Addictive Behaviors, measuring the treatment provider's responses on the "Spiritual Belief Scale" (a
2625:
These findings led us to hypothesize that a concerted upregulation of the cAMP pathway is a general mechanism of opiate tolerance and dependence. ... We thus extended our hypothesis to suggest that, particularly within brain reward regions such as NAc, cAMP pathway upregulation represents a
1653:
at the
University of Chicago reported an analysis on disparities within admissions for substance abuse treatment in the Appalachian region, which comprises 13 states and 410 counties in the Eastern part of the U.S. While their findings for most demographic categories were similar to the national
851:
agonists into the locus coeruleus leads to a decrease in LC firing and norepinephrine release during withdrawal. A possible mechanism involves upregulation of NMDA receptors, which is supported by the attenuation of withdraw by NMDA receptor antagonists. Physical dependence on opioids has been
992:
Treatments for addiction vary widely according to the types of drugs involved, amount of drugs used, duration of the drug addiction, medical complications and the social needs of the individual. Determining the best type of recovery program for an addicted person depends on a number of factors,
1730:
in the City and County of San
Francisco. The bill was vetoed on September 30, 2018, by California Governor Jerry Brown. The legality of these sites are still in discussion, so there are no such sites in the United States yet. However, there is growing international evidence for successful safe
1241:
in the context of opioid dependence. These approaches are aimed at the process of detoxification. Medical professionals weigh the consequences of withdrawal symptoms against the risk of staying dependent on these substances. These withdrawal symptoms can be very difficult and painful times for
767:. A sustained activation of CREB thus forces a larger dose to be taken to reach the same effect. In addition, it leaves the user feeling generally depressed and dissatisfied, and unable to find pleasure in previously enjoyable activities, often leading to a return to the drug for another dose.
1861:
The official diagnosis of drug addiction by the Diagnostic and Statistic Manual of Mental Disorders (2000), which makes distinctions between drug use, abuse, and substance dependence, is flawed. First, diagnosis of drug use versus abuse can be arbitrary and reflect cultural norms, not medical
1215:
There are two routes typically applied to a cognitive approach to substance abuse: tracking the thoughts that pull patients to addiction and tracking the thoughts that prevent them if so from relapsing. Behavioral techniques have the widest application in treating substance related disorders.
1189:
There is little evidence to confirm the safety or efficacy of most alternative therapies. Much of the information currently known about these therapies makes it clear that many have not been shown to be efficacious. Well-designed, stringently controlled research should be done to evaluate the
1694:. Even though the cost of producing most illegal addictive substances is very low, their illegality combined with the addict's need permits the seller to command a premium price, often hundreds of times the production cost. As a result, addicts sometimes turn to crime to support their habit.
3003:
Chambless, Dianne L.; Sanderson, William C.; Shoham, Varda; Johnson, Suzanne Bennett; Pope, Kenneth S.; Crits-Christoph, Paul; Baker, Mary; Johnson, Benjamin; Woody, Sheila R.; Sue, Stanley; Beutler, Larry; Williams, David A.; McCurry, Susan. "An Update on Empirically Validated Therapies".
996:
Many different ideas circulate regarding what is considered a successful outcome in the recovery from addiction. Programs that emphasize controlled drinking exist for alcohol addiction. Opiate replacement therapy has been a medical standard of treatment for opioid addiction for many years.
1654:
findings by NSDUH, they had different results for racial/ethnic groups which varied by sub-regions. Overall, Whites were the demographic with the largest admission rate (83%), while Alaskan Native, American Indian, Pacific Islander, and Asian populations had the lowest admissions (1.8%).
1236:
Another approach is to use medicines that interfere with the functions of the drugs in the brain. Similarly, one can also substitute the misused substance with a weaker, safer version to slowly taper the patient off of their dependence. Such is the case with
1376:, and dramatic increases in the recommendation of drug usage by clinical practitioners have exacerbated the problem significantly in the 20th century. Improved means of active biological agent manufacture and the introduction of synthetic compounds, such as
344:
Withdrawal is the body's reaction to abstaining from a substance upon which a person has developed a dependence syndrome. When dependence has developed, cessation of substance-use produces an unpleasant state, which promotes continued drug use through
165:. This was done because "the tolerance and withdrawal that previously defined dependence are actually very normal responses to prescribed medications that affect the central nervous system and do not necessarily indicate the presence of an addiction."
1021:
Residential drug treatment can be broadly divided into two camps: 12-step programs and therapeutic communities. 12-step programs are a nonclinical support-group and spiritual-based approach to treating addiction. Therapy typically involves the use of
1049:(rehab) centers offer a residential treatment program for some of the more seriously addicted, in order to isolate the patient from drugs and interactions with other users and dealers. Outpatient clinics usually offer a combination of individual
1223:. It uses the principle of pairing abused substances with unpleasant stimuli or conditions; for example, pairing pain, electrical shock, or nausea with alcohol consumption. The use of medications may also be used in this approach, such as using
1185:, are used by some practitioners to alleviate the symptoms of drug addiction. In 1997, the American Medical Association (AMA) adopted, as policy, the following statement after a report on a number of alternative therapies including acupuncture:
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compared the harm and dependence liability of 20 drugs, using a scale from zero to three for physical dependence, psychological dependence, and pleasure to create a mean score for dependence. Selected results can be seen in the chart below.
364:(NAS), which can have severe and life-threatening effects. Addiction to drugs such as alcohol in expectant mothers not only causes NAS, but also an array of other issues which can continually affect the infant throughout their lifetime.
1848:
Addictive drugs are both rewarding and reinforcing. ... Familiar pharmacologic terms such as tolerance, dependence, and sensitization are useful in describing some of the time-dependent processes that underlie addiction. ...
1090:
to reduce cravings and propensity for relapse amongst addicts to any drug, especially effective in stimulant users, and alcoholics (in which it is nearly as effective as benzodiazepines in preventing complications); using
1501:
When surveying populations based on gender in those ages 12 and older, it was observed that males had a higher substance dependence rate than females. However, the difference in the rates are not apparent until after age
3180:
3046:
Dutcher, Linda W.; Anderson, Raymond; Moore, Marah; Luna-Anderson, Carol; Meyers, Robert J.; Delaney, Harold D.; Smith, Jane Ellen (2009). "Community Reinforcement and Family Training (CRAFT): An effectiveness study".
148:), substance dependence is redefined as a drug addiction, and can be diagnosed without the occurrence of a withdrawal syndrome. It was described accordingly: "When an individual persists in use of
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Moggi F, Giovanoli A, Strik W, Moos BS, Moos RH (January 2007). "Substance use disorder treatment programs in Switzerland and the USA: Program characteristics and 1-year outcomes".
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training (CRAFT) have helped family members to get their loved ones into treatment. Motivational intervention has also shown to be an effective treatment for substance dependence.
782:. This activation influences the dysregulated emotional state associated with psychological dependence. They found that as drug use escalates, so does the presence of CRF in human
140:
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It is unclear whether laws against illegal drug use do anything to stem usage and dependency. In jurisdictions where addictive drugs are illegal, they are generally supplied by
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For the entirety of US history, drugs have been used by some members of the population. In the country's early years, most drug use by the settlers was of alcohol or tobacco.
199:– psychoactive substances that with repeated use are associated with significantly higher rates of substance use disorders, due in large part to the drug's effect on brain
2800:
Reynolds M, Mezey G, Chapman M, Wheeler M, Drummond C, Baldacchino A (March 2005). "Co-morbid post-traumatic stress disorder in a substance misusing clinical population".
357:), or both. Chemical and hormonal imbalances may arise if the substance is not re-introduced. Psychological stress may also result if the substance is not re-introduced.
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had the lowest rates. Furthermore, dependence rates were greater in unemployed populations ages 18 and older and in metropolitan-residing populations ages 12 and older.
2587:"Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function""
1666:, addictive drugs may be legal, legal only as part of a government sponsored study, illegal to use for any purpose, illegal to sell, or even illegal to merely possess.
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120:
factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence.
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1997) such as depression, and can help reduce or eliminate withdrawal symptomology when withdrawing from physiologically addictive drugs. Some examples are using
993:
including: personality, drugs of choice, concept of spirituality or religion, mental or physical illness, and local availability and affordability of programs.
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developed by the Xenova Group which is used to negate the effects of cocaine, making it suitable for use in treatment of addiction. It is created by combining
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on smokers revealed that 80% of smokers quit for six months following the treatment, and 60% remained smoking free for 5 years following the treatment.
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349:; i.e., the drug is used to escape or avoid re-entering the associated withdrawal state. The withdrawal state may include physical-somatic symptoms (
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124:
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Meyers, Robert J.; Smith, Jane Ellen; Lash, Denise N. (2005). "A program for engaging treatment-refusing substance abusers into treatment: CRAFT".
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meet major responsibilities at work, school, or home. Depending on the level of severity, this disorder is classified as mild, moderate, or severe.
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Smith, Jane Ellen; Milford, Jaime L.; Meyers, Robert J. (2004). "CRA and CRAFT: Behavioral approaches to treating substance-abusing individuals".
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770:
In addition to CREB, it is hypothesized that stress mechanisms play a role in dependence. Koob and Kreek have hypothesized that during drug use,
86:
because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of
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AJ Giannini, RQ Quinones, DM Martin. Role of beta-endorphin and cAMP in addiction and mania. Society for Neuroscience Abstracts. 15:149, 1998.
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732:
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Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse".
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serve to protect and promote public health by controlling the manufacturing, marketing, and distribution of products, like medications.
3469:, NSDUH Series H-48, HHS Publication No. (SMA) 14-4863. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2014.
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Martell BA, Mitchell E, Poling J, Gonsai K, Kosten TR (July 2005). "Vaccine pharmacotherapy for the treatment of cocaine dependence".
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254:– dependence socially seen as being extremely mild compared to physical dependence (e.g., with enough willpower it could be overcome)
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2716:"It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system"
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Capture rates enumerate the percentage of users who reported that they had become dependent to their respective drug at some point.
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Increased expression of AMPA receptors in nucleus accumbens MSNs is a potential mechanism of aversion produced by drug withdrawal.
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of the drug of study. Other studies in this review showed dysregulation of other neuropeptides that affect the HPA axis, including
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Ball JC, van de Wijngaart GF (July 1994). "A Dutch addict's view of methadone maintenance--an American and a Dutch appraisal".
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210:– an adaptive state associated with a withdrawal syndrome upon cessation of repeated exposure to a stimulus (e.g., drug intake)
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1116:, with an opioid that can be administered legally, reduces or eliminates drug cravings, and does not produce a high, such as
1046:
1045:. They are commonly known and used for a variety of addictions for the individual addicted and the family of the individual.
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724:
82:, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a
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3481:"An Analysis of Mental Health and Substance Abuse Disparities & Access to Treatment Services in the Appalachian Region"
2191:
Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 15: Reinforcement and Addictive Disorders". In Sydor A, Brown RY (eds.).
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Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 15: Reinforcement and Addictive Disorders". In Sydor A, Brown RY (eds.).
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scale measuring belief in the four spiritual characteristics of AA identified by Ernest Kurtz); the scores were found to
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1948:"Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms"
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Motlagh, Farid Esmaeili; Ibrahim, Fatimah; Rashid, Rusdi Abd; Seghatoleslam, Tahereh; Habil, Hussain (5 April 2016).
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of a particular substance, route of administration, and time are critical factors for developing a drug dependence.
288:– a condition in which the use of substances leads to clinically and functionally significant impairment or distress
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is defined as an adaptive state that develops in response to repeated drug administration, and is unmasked during
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The defining feature of addiction is compulsive, out-of-control drug use, despite negative consequences. ...
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In the United States, drug policy is primarily controlled by the federal government. The Department of Justice's
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Giannini AJ (June 1996). "Alexithymia, affective disorders and substance abuse: possible cross-relationships".
2054:"The ICD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines"
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354:
250:
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O'Donohue, William; Ferguson, Kyle E. (2006). "Evidence-based practice in psychology and behavior analysis".
2640:"The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal"
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Behavioral programming is considered critical in helping those with addictions achieve abstinence. From the
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3005:
1220:
1169:
1140:
in the treatment provider's responses on the "Addiction Belief Scale" (a scale measuring adherence to the
1010:
929:
910:
346:
284:
5346:
5341:
5269:
5254:
5166:
4764:
4231:
4205:
4015:
3954:
3019:
1795:
1766:
1741:
1157:
272:– stimuli that the brain interprets as intrinsically positive and desirable or as something to approach
3706:"WHO Expert Committee on Drug Dependence – WHO Technical Report Series, No. 915 – Thirty-third Report"
5264:
5121:
4809:
4786:
4728:
4487:
4260:
4000:
2679:
Noda Y, Nabeshima T (October 2004). "Opiate physical dependence and N-methyl-D-aspartate receptors".
1137:
1034:
4626:
3010:
5188:
5071:
5021:
5016:
5006:
5001:
4952:
4718:
4520:
4405:
4349:
4339:
4182:
4093:
3947:
3942:
3834:
3805:
3637:
2453:
2348:"Supporting mothers with opioid addiction is the best bet in fighting neonatal abstinence syndrome"
1751:
1038:
1030:
966:
923:
870:
841:
829:
791:
783:
350:
234:
97:
1706:
enforces controlled substances laws and regulations. The Department of Health and Human Services'
393:
of a drug varies from substance to substance, and from individual to individual. Dose, frequency,
5371:
5334:
5309:
5299:
5094:
5031:
5011:
4713:
4634:
4334:
4276:
4065:
3279:
2913:
2402:
2325:
1790:
1670:
1133:
917:
882:
803:
132:
117:
31:
3676:
1216:
Behavioral psychologists can use the techniques of "aversion therapy", based on the findings of
5329:
5171:
4698:
4377:
3965:
3763:
3373:
3348:
3271:
3212:
3161:
2958:
2905:
2852:
2817:
2782:
2747:
2696:
2661:
2616:
2567:
2518:
2394:
2292:
2239:
2196:
2170:
2030:
1977:
1925:
1835:
1396:
888:
779:
736:
214:
83:
62:
1946:
Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (2012).
4862:
4759:
4739:
4567:
4051:
3698:
3263:
3202:
3192:
3151:
3141:
3110:
3083:
3056:
2985:
2948:
2940:
2931:
Schaler JA (1997). "Addiction Beliefs of Treatment Providers: Factors Explaining Variance".
2897:
2844:
2809:
2774:
2737:
2727:
2688:
2651:
2606:
2598:
2557:
2549:
2508:
2500:
2420:
2386:
2282:
2274:
2229:
2162:
2049:
2020:
2012:
1967:
1959:
1915:
1907:
1675:
1059:
394:
243:
3732:
5353:
5237:
4962:
4708:
4703:
4372:
4194:
3825:
3799:
3467:
Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings
3032:
2876:
2053:
1771:
1761:
1691:
1381:
1063:
1055:
1042:
833:
811:
752:
744:
644:
586:
548:
339:
226:
184:
158:
128:
87:
35:
3399:
296:– the diminishing effect of a drug resulting from repeated administration at a given dose
2447:"Dangerousness of Drugs A Guide To The Risks And Harms Associated With Substance Misuse"
2317:
222:– the escalating effect of a drug resulting from repeated administration at a given dose
5219:
4751:
4688:
4442:
4132:
3888:
3713:
3429:
3341:
3301:
3207:
3156:
3129:
2778:
2742:
2715:
2611:
2586:
2562:
2538:"Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis"
2537:
2513:
2488:
2287:
2262:
2234:
2217:
2079:
2067:
2025:
2000:
1972:
1947:
1920:
1895:
1872:
1870:
1746:
1403:
drugs were synthesized and discovered, opening up new avenues to substance dependency.
986:
840:
has been implicated as the mechanism responsible for certain aspects of opioid-induced
799:
764:
664:
605:
510:
292:
188:
149:
92:
2489:"Stress, dysregulation of drug reward pathways, and the transition to drug dependence"
2390:
844:. The temporal course of withdrawal correlates with LC firing, and administration of
5386:
5232:
4657:
3789:
2848:
2813:
2656:
2639:
2553:
2016:
1121:
1096:
1071:
1067:
956:
807:
740:
276:
267:
258:
200:
109:
105:
3646:
3642:
3283:
2917:
4288:
3267:
2602:
2504:
2406:
1663:
1373:
982:
978:
720:
491:
17:
1882:
977:
Addiction is a complex but treatable condition. It is characterized by compulsive
3657:
2692:
1963:
4693:
4528:
4479:
2901:
1877:
1687:
1390:
The 19th century saw opium usage in the US become much more common and popular.
1369:
1217:
1182:
567:
263:– stimuli that increase the probability of repeating behaviors paired with them
30:
This article is about drug and alcohol dependence. For alcohol dependence, see
5304:
5144:
4981:
4615:
4172:
4126:
3197:
3146:
2944:
2870:
Nils Bejerot: Swedish addiction epidemic in an international perspective, 1988
1357:
1259:
1224:
1195:
1100:
1079:
1075:
1050:
902:
795:
402:
67:
2962:
2732:
2174:
2123:
1228:
that psychologists may use as treatment for those with substance dependence.
5047:
4673:
4661:
4509:
3626:
3622:
3433:
2166:
1117:
1113:
1092:
1083:
1006:
873:, evidence of tolerance or withdrawal, or without physiological dependence.
756:
280:– an amplified response to a stimulus resulting from repeated exposure to it
195:
179:
3275:
3216:
3165:
2856:
2821:
2751:
2700:
2620:
2571:
2522:
2398:
2296:
2243:
2034:
1981:
1929:
1563:
Illicit Drug Dependence Demographics (Education, Employment, and Regional)
1160:
literature, several evidence based intervention programs have emerged: (1)
1086:, for withdrawal from barbiturates or benzodiazepines; using drugs such as
161:
and substance dependence were eliminated and replaced with the category of
3517:
2909:
2869:
2786:
2665:
2278:
239:
4841:
4582:
4423:
4418:
4317:
4299:
4146:
4005:
1669:
Most countries have legislation which brings various drugs and drug-like
1391:
1377:
1285:
1281:
1238:
1109:
1087:
943:
898:
894:
760:
654:
529:
434:
113:
3605:
4548:
4249:
3571:"Bill Text - AB-186 Controlled substances: overdose prevention program"
1361:
1273:
1263:
1255:
694:
674:
472:
453:
135:
3437:
2953:
4903:
4361:
3617:
3114:
3087:
3060:
2989:
1269:
1105:
874:
866:
684:
430:
27:
Need for a drug, whose discontinuation results in withdrawal symptoms
3518:"Drug Enforcement in the United States: History, Policy, and Trends"
3049:
Journal of Behavior Analysis in Health, Sports, Fitness and Medicine
1911:
2193:
Molecular Neuropharmacology: A Foundation for Clinical Neuroscience
2093:
1832:
Molecular Neuropharmacology: A Foundation for Clinical Neuroscience
1395:
not become addicted to morphine if it was injected into them via a
376:
Mental health as a risk factor for illicit drug dependency or abuse
4913:
4908:
4898:
4893:
4888:
4882:
4875:
4868:
4836:
4821:
2263:"Neurobiologic Advances from the Brain Disease Model of Addiction"
1365:
1360:
of drug addiction has occurred to some degree throughout recorded
1277:
1251:
371:
154:
3343:
The chemical muse: drug use and the roots of Western civilization
2195:(2nd ed.). New York: McGraw-Hill Medical. pp. 364–375.
1834:(2nd ed.). New York: McGraw-Hill Medical. pp. 364–368.
4831:
4826:
4815:
3479:
Zhang Z, Infante A, Meit M, English N, Dunn M, Bowers K (2008).
1002:
4630:
3736:
4856:
3370:
Pharmakon: Plato, Drug Culture, and Identity in Ancient Athens
2318:"Are addictions classified as being a mental health disorder?"
1296:
739:(NAcc) is one brain structure that has been implicated in the
96:, a distinct concept from substance dependence, is defined as
837:
715:
Two factors have been identified as playing pivotal roles in
187:
disorder characterized by persistent use of drugs (including
100:, out-of-control drug use, despite negative consequences. An
3076:
International Journal of Behavioral Consultation and Therapy
1417:
dependence were in their twenties, unemployed, and men. The
1372:
practices, improvements in access to drugs, advancements in
3465:
Substance Abuse and Mental Health Services Administration,
2001:"Natural rewards, neuroplasticity, and non-drug addictions"
3400:"History of Drug Use and Drug Users in the United States"
2094:"Diagnostic criteria for Substance Dependence: DSM IV–TR"
230:– symptoms that occur upon cessation of repeated drug use
1896:"Transcriptional and epigenetic mechanisms of addiction"
786:. In rat models, the separate use of CRF inhibitors and
751:(cAMP) immediately after a high and triggers changes in
90:
and that necessitates the re-consumption of the drug. A
3671:
3546:"Needle exchanges find new champions among Republicans"
1321:
360:
Infants also experience substance withdrawal, known as
826:
771:
2186:
2184:
1508:
Substance Use in Different Genders w/ Respect to Age
1194:
In addition, new research surrounding the effects of
141:
Diagnostic and Statistical Manual of Mental Disorders
5107:
Community reinforcement approach and family training
3595:
1825:
1823:
1821:
1288:
in the human body so that it is no longer effective.
806:, which enkephalin acts upon, is influential in the
763:
release into the NAcc by temporarily inhibiting the
5292:
5218:
5197:
5135:
5080:
5059:
5046:
4971:
4940:
4931:
4800:
4727:
4681:
4672:
4593:
4547:
4508:
4417:
4360:
4316:
4287:
4248:
4193:
4145:
4119:
4092:
4014:
3983:
3964:
3927:
3903:
3896:
3887:
3853:
3773:
3599:
1384:, are also factors contributing to drug addiction.
191:) despite substantial harm and adverse consequences
170:
61:
53:
48:
3340:
2423:. National Institute on Drug Abuse. January 2014.
3693:A social history of America's most popular drugs.
138:. Within the framework of the 4th edition of the
4300:Acute intoxication from hallucinogens (bad trip)
2261:Volkow ND, Koob GF, McLellan AT (January 2016).
1187:
238:– dependence that involves persistent physical–
3672:American Society of Addiction Medicine website
962:304.90 Other (or unknown) substance dependence
4642:
3748:
1310:The examples and perspective in this section
1280:but being used to create human anti-nicotine
314:
8:
1806:Severity of Alcohol Dependence Questionnaire
4305:Hallucinogen persisting perception disorder
2452:. National Addiction Center. Archived from
1058:for alcohol detoxification, which prevents
778:(HPA axis) and other stress systems in the
5056:
4937:
4678:
4649:
4635:
4627:
3900:
3893:
3755:
3741:
3733:
3596:
3298:"CelticPharma: TA-NIC Nicotine Dependence"
1328:, or create a new section, as appropriate.
865:"Substance dependence", as defined in the
802:that regulates pain. It also appears that
632:
409:
321:
307:
45:
3206:
3196:
3155:
3145:
3009:
2952:
2741:
2731:
2655:
2610:
2561:
2512:
2286:
2233:
2024:
1971:
1919:
1786:Alcohol Use Disorders Identification Test
1344:Learn how and when to remove this message
1062:and complications; using a slow taper of
3393:
3391:
3389:
3368:Rinella, Michael A. (23 November 2011).
3181:"Acupuncture therapy for drug addiction"
3130:"Acupuncture therapy for drug addiction"
2218:"Cellular basis of memory for addiction"
1561:
1506:
1423:
125:International Classification of Diseases
4435:Kindling (sedative–hypnotic withdrawal)
1894:Robison AJ, Nestler EJ (October 2011).
1817:
1720:Comprehensive Crime Control Act of 1984
242:withdrawal symptoms (e.g., fatigue and
4578:Chronic solvent-induced encephalopathy
3243:. New York, NY: Worth. pp. 1–589.
3028:
3017:
1425:Substance Use in Racial/Ethnic Groups
1419:National Survey on Drug Use and Health
1144:or the free-will model of addiction).
167:
4102:Alcohol-induced respiratory reactions
3461:
3459:
3457:
3455:
3453:
3451:
3234:
3232:
3230:
3228:
3226:
2358:from the original on 11 November 2017
2328:from the original on 11 November 2021
1704:Drug Enforcement Administration (DEA)
733:cAMP response element binding protein
127:classifies substance dependence as a
7:
3410:from the original on 7 December 2013
3179:Miller, Michael (24 February 2023).
1168:; (3) cue exposure therapy; and (4)
1033:, with prominent examples including
747:. In the NAcc, CREB is activated by
353:), emotional-motivational symptoms (
5320:Discrimination against drug addicts
3699:NIDA for Teens: Brain and Addiction
3697:National Institute on Drug Abuse: "
810:and can regulate the expression of
776:hypothalamic–pituitary–adrenal axis
5182:Tobacco cessation clinics in India
4609:Anabolic-androgenic steroids abuse
4238:Synthetic cannabinoid use disorder
2779:10.1111/j.1360-0443.1994.tb00974.x
2493:The American Journal of Psychiatry
2427:from the original on 17 April 2014
2222:Dialogues in Clinical Neuroscience
1708:Food and Drug Administration (FDA)
1190:efficacy of alternative therapies.
959:(or phencyclidine-like) dependence
25:
4158:Caffeine-induced anxiety disorder
3525:Federation of American Scientists
2773:(7): 799–802, discussion 803–14.
2305:of severe substance-use disorder.
2134:from the original on 13 June 2015
2104:from the original on 12 June 2015
1029:One of many recovery methods are
171:Addiction and dependence glossary
5367:
5366:
5245:Low-threshold treatment programs
5112:Motivational enhancement therapy
4211:Cannabinoid hyperemesis syndrome
2849:10.1016/j.drugalcdep.2006.05.017
2814:10.1016/j.drugalcdep.2004.08.017
2714:Chartoff EH, Connery HS (2014).
2681:European Journal of Pharmacology
2554:10.1016/j.neuropharm.2008.06.075
2487:Koob G, Kreek MJ (August 2007).
2017:10.1016/j.neuropharm.2011.03.010
1651:National Opinion Research Center
1301:
1166:community reinforcement approach
877:substance dependencies include:
5325:Dopamine dysregulation syndrome
5315:Category:Vaccines against drugs
4168:Caffeine-induced sleep disorder
4060:Fetal alcohol spectrum disorder
2933:Addiction Research & Theory
2536:Carlezon WA, Thomas MJ (2009).
2267:New England Journal of Medicine
1716:Controlled Substances Act (CSA)
1181:Alternative therapies, such as
4562:Sudden sniffing death syndrome
4217:Intravenous marijuana syndrome
3811:Post-acute-withdrawal syndrome
3268:10.1016/j.biopsych.2005.04.032
2603:10.1016/j.brainres.2015.12.039
2505:10.1176/appi.ajp.2007.05030503
1690:, who are often involved with
1070:, sometimes including another
1047:Substance-abuse rehabilitation
749:cyclic adenosine monophosphate
725:corticotropin-releasing factor
1:
4948:Adverse childhood experiences
4389:Opioid-induced endocrinopathy
2638:Rasmussen K (December 1995).
2391:10.1016/S0140-6736(07)60464-4
1952:Journal of Psychoactive Drugs
755:that affect proteins such as
5177:Nicotine replacement therapy
5162:Intensive outpatient program
5150:Residential treatment center
5090:Cognitive behavioral therapy
4602:Anabolic-androgenic steroids
4129:(alcohol use disorder (AUD))
4071:Positional alcohol nystagmus
4036:Alcohol-related brain damage
3372:. Rowman & Littlefield.
2693:10.1016/j.ejphar.2004.07.017
2657:10.1016/0893-133X(95)00082-O
2216:Nestler EJ (December 2013).
1964:10.1080/02791072.2012.662112
1900:Nature Reviews. Neuroscience
1722:, and Anti-Drug Abuse Acts.
1024:cognitive-behavioral therapy
759:; dynorphin peptides reduce
362:neonatal abstinence syndrome
5393:Substance-related disorders
4775:Internet addiction disorder
4466:Benzodiazepine use disorder
4395:Opioid-induced constipation
4383:Opioid-induced hyperalgesia
4077:Wernicke–Korsakoff syndrome
4041:Alcohol withdrawal syndrome
3830:Substance-related disorders
3795:Substance-induced psychosis
3767:substance-related disorders
3339:Hillman DC (22 July 2008).
2902:10.2466/pr0.1996.78.3c.1389
2837:Drug and Alcohol Dependence
2802:Drug and Alcohol Dependence
2161:(3): 36–37. 11 March 2014.
1324:, discuss the issue on the
790:antagonists both decreased
34:. For substance abuse, see
5414:
5210:List of twelve-step groups
4163:Caffeine-induced psychosis
4094:Respiratory tract diseases
4079:(WKS, Korsakoff psychosis)
3876:Combined drug intoxication
3575:leginfo.legislature.ca.gov
3516:Sacco L (2 October 2014).
3103:The Behavior Analyst Today
2978:The Behavior Analyst Today
2585:Nestler EJ (August 2016).
2070:. bluebook.doc. p. 65
1999:Olsen CM (December 2011).
1276:in development similar to
1162:behavioral marital therapy
1126:opioid replacement therapy
337:
29:
5362:
5275:Supervised injection site
5205:Addiction recovery groups
5157:Heroin-assisted treatment
5117:Motivational interviewing
4472:Benzodiazepine dependence
4456:Benzodiazepine withdrawal
4266:Prenatal cocaine exposure
3929:Gastrointestinal diseases
3198:10.1186/s13020-016-0088-7
3147:10.1186/s13020-016-0088-7
2945:10.3109/16066359709002970
2720:Frontiers in Pharmacology
2063:World Health Organization
1757:Risk factors in pregnancy
1154:applied behavior analysis
1031:12-step recovery programs
907:benzodiazepine dependence
729:gene transcription factor
302:
175:
4958:Psychological dependence
4792:Digital media addictions
4031:Alcoholic polyneuropathy
3995:Alcohol-related dementia
3913:Alcoholic cardiomyopathy
3866:Polysubstance dependence
3839:Psychological dependence
3677:Health-EU Portal – Drugs
3325:Drug Addiction Treatment
2733:10.3389/fphar.2014.00116
1878:MedlinePlus Encyclopedia
951:Polysubstance dependence
871:physiological dependence
869:, can be diagnosed with
717:psychological dependence
711:Psychological dependence
422:Psychological dependence
355:psychological dependence
251:psychological dependence
104:is a drug which is both
5260:Needle exchange program
5250:Managed alcohol program
5228:Category:Harm reduction
4451:Benzodiazepine overdose
4083:Wernicke encephalopathy
3937:Alcoholic liver disease
3905:Cardiovascular diseases
2644:Neuropsychopharmacology
2167:10.1108/rr-10-2013-0256
1801:Paddington Alcohol Test
1284:in a person to destroy
1011:mental health disorders
798:which is an endogenous
706:Biomolecular mechanisms
163:substance use disorders
5280:Tobacco harm reduction
5100:Contingency management
5067:Alcohol detoxification
4780:Internet sex addiction
4537:Amphetamine dependence
4498:Barbiturate dependence
4329:Green Tobacco Sickness
4227:Amotivational syndrome
4107:Alcoholic lung disease
4047:Alcoholic hallucinosis
4026:Alcoholic hallucinosis
3974:Alcoholic ketoacidosis
3918:Alcohol flush reaction
3786:Substance intoxication
3712:. 2003. Archived from
3687:Trips Beyond Addiction
3027:Cite journal requires
2421:"Marijuana Drug Facts"
2124:"Substance Dependence"
1883:Substance use disorder
1731:injection facilities.
1433:Dependence/Abuse Rate
1221:classical conditioning
1192:
1170:contingency management
1148:Behavioral programming
930:Amphetamine dependence
911:barbiturate dependence
905:dependence (including
377:
347:negative reinforcement
285:substance use disorder
84:psychoactive substance
5342:Motivational salience
5270:Stimulant maintenance
5255:Moderation Management
5167:Methadone maintenance
4232:Cannabis use disorder
3955:Auto-brewery syndrome
2890:Psychological Reports
2324:. 16 September 2020.
2279:10.1056/NEJMra1511480
1796:CRAFFT Screening Test
1767:Stimulant maintenance
1742:Addictive personality
1177:Alternative therapies
1158:behavioral psychology
932:(or amphetamine-like)
375:
5398:Substance dependence
5265:Responsible drug use
5122:Motivational therapy
4787:Video game addiction
4488:Barbiturate overdose
4261:Cocaine intoxication
4001:Alcohol intoxication
3843:Substance dependence
3682:people, drug addicts
2875:22 June 2007 at the
1728:safe injection sites
1322:improve this section
1312:may not represent a
1202:Treatment and issues
1035:Alcoholics Anonymous
825:Upregulation of the
425:Physical dependence
391:dependence liability
387:dependence potential
381:Dependence potential
157:(released in 2013),
76:Substance dependence
49:Substance dependence
5189:Twelve-step program
5072:Drug detoxification
4953:Physical dependence
4521:Stimulant psychosis
4406:Opioid use disorder
4350:Nicotine dependence
4340:Nicotine withdrawal
4183:Caffeine dependence
3943:Alcoholic hepatitis
3835:Physical dependence
3806:Neonatal withdrawal
3404:www.druglibrary.org
3241:Abnormal Psychology
2896:(3 Pt 2): 1389–90.
2548:(Suppl 1): 122–32.
1752:Physical dependence
1620:small metropolitan
1608:no-degree, college
1600:large metropolitan
1564:
1509:
1426:
1407:Society and culture
1156:literature and the
1104:illicitly-obtained
1039:Narcotics Anonymous
967:Nicotine dependence
924:Cannabis dependence
842:physical dependence
830:signal transduction
821:Physical dependence
792:self-administration
784:cerebrospinal fluid
351:physical dependence
235:physical dependence
153:Disorders." In the
18:Chemical dependency
5347:Incentive salience
5335:Inhibitory control
5310:Category:Addiction
5300:Addiction medicine
5095:Relapse prevention
5032:Tanning dependence
4335:Nicotine poisoning
4277:Cocaine dependence
4206:Cannabis arteritis
4066:Korsakoff syndrome
3966:Endocrine diseases
3304:on 6 December 2009
1791:CAGE questionnaire
1574:Employment status
1562:
1507:
1424:
1232:Medicinal approach
1211:Cognitive approach
918:Cocaine dependence
883:Alcohol dependence
861:DSM classification
804:ÎĽ-opioid receptors
378:
215:drug sensitization
118:gene transcription
32:Alcohol dependence
5380:
5379:
5330:Cognitive control
5288:
5287:
5172:Smoking cessation
5127:Physical exercise
5042:
5041:
5028:Non-drug stimuli
4927:
4926:
4771:Internet-related
4624:
4623:
4378:Opioid withdrawal
4141:
4140:
4115:
4114:
3716:on 9 October 2012
3667:
3666:
3442:Our World in Data
3436:(December 2019).
3379:978-0-7391-4687-3
3354:978-0-312-35249-3
3239:Comer RJ (2013).
2542:Neuropharmacology
2385:(9566): 1047–53.
2155:Reference Reviews
2050:Sartorius, Norman
2005:Neuropharmacology
1662:Depending on the
1647:
1646:
1640:non-metropolitan
1628:college graduate
1556:
1555:
1499:
1498:
1489:American Indian/
1480:Pacific Islander
1478:Native Hawaiian/
1397:hypodermic needle
1354:
1353:
1346:
1272:is a proprietary
1262:with inactivated
889:Opioid dependence
780:extended amygdala
737:nucleus accumbens
703:
702:
623:
622:
331:
330:
220:reverse tolerance
73:
72:
43:Medical condition
16:(Redirected from
5405:
5370:
5369:
5057:
4938:
4863:G9a-like protein
4679:
4651:
4644:
4637:
4628:
4568:Toluene toxicity
4052:Delirium tremens
3948:Zieve's syndrome
3901:
3894:
3757:
3750:
3743:
3734:
3725:
3723:
3721:
3597:
3586:
3585:
3583:
3581:
3567:
3561:
3560:
3558:
3556:
3542:
3536:
3535:
3533:
3531:
3522:
3513:
3507:
3506:
3504:
3502:
3496:
3490:. Archived from
3485:
3476:
3470:
3463:
3446:
3445:
3426:
3420:
3419:
3417:
3415:
3395:
3384:
3383:
3365:
3359:
3358:
3346:
3336:
3330:
3329:
3320:
3314:
3313:
3311:
3309:
3300:. Archived from
3294:
3288:
3287:
3256:Biol. Psychiatry
3251:
3245:
3244:
3236:
3221:
3220:
3210:
3200:
3185:Chinese Medicine
3176:
3170:
3169:
3159:
3149:
3134:Chinese Medicine
3125:
3119:
3118:
3115:10.1037/h0100044
3098:
3092:
3091:
3088:10.1037/h0100737
3071:
3065:
3064:
3061:10.1037/h0100376
3043:
3037:
3036:
3030:
3025:
3023:
3015:
3013:
3000:
2994:
2993:
2990:10.1037/h0100155
2973:
2967:
2966:
2956:
2928:
2922:
2921:
2885:
2879:
2867:
2861:
2860:
2832:
2826:
2825:
2797:
2791:
2790:
2762:
2756:
2755:
2745:
2735:
2711:
2705:
2704:
2676:
2670:
2669:
2659:
2635:
2629:
2628:
2614:
2582:
2576:
2575:
2565:
2533:
2527:
2526:
2516:
2484:
2478:
2475:
2469:
2468:
2466:
2464:
2459:on 11 April 2014
2458:
2451:
2443:
2437:
2436:
2434:
2432:
2417:
2411:
2410:
2374:
2368:
2367:
2365:
2363:
2344:
2338:
2337:
2335:
2333:
2314:
2308:
2307:
2290:
2258:
2252:
2251:
2237:
2213:
2207:
2206:
2188:
2179:
2178:
2150:
2144:
2143:
2141:
2139:
2120:
2114:
2113:
2111:
2109:
2090:
2084:
2083:
2077:
2075:
2058:
2045:
2039:
2038:
2028:
1996:
1990:
1989:
1975:
1943:
1937:
1936:
1923:
1891:
1885:
1874:
1865:
1864:
1827:
1676:criminal offence
1568:Education level
1565:
1510:
1427:
1349:
1342:
1338:
1335:
1329:
1305:
1304:
1297:
1060:delirium tremens
839:
828:
773:
727:" (CRF) and the
633:
410:
395:pharmacokinetics
323:
316:
309:
244:delirium tremens
168:
78:, also known as
46:
21:
5413:
5412:
5408:
5407:
5406:
5404:
5403:
5402:
5383:
5382:
5381:
5376:
5358:
5354:Sober companion
5284:
5238:Reagent testing
5214:
5193:
5137:
5131:
5082:
5076:
5051:
5049:
5038:
4967:
4923:
4810:Transcriptional
4802:
4796:
4723:
4709:Methylphenidate
4704:Methamphetamine
4668:
4655:
4625:
4620:
4589:
4550:
4543:
4504:
4422:
4413:
4373:Opioid overdose
4356:
4312:
4283:
4244:
4189:
4137:
4111:
4088:
4017:
4010:
3987:system diseases
3986:
3979:
3960:
3923:
3883:
3855:
3849:
3826:Substance abuse
3769:
3761:
3719:
3717:
3704:
3668:
3663:
3662:
3608:
3594:
3589:
3579:
3577:
3569:
3568:
3564:
3554:
3552:
3544:
3543:
3539:
3529:
3527:
3520:
3515:
3514:
3510:
3500:
3498:
3497:on 17 June 2018
3494:
3483:
3478:
3477:
3473:
3464:
3449:
3430:Ritchie, Hannah
3428:
3427:
3423:
3413:
3411:
3398:Casey, Elaine.
3397:
3396:
3387:
3380:
3367:
3366:
3362:
3355:
3338:
3337:
3333:
3322:
3321:
3317:
3307:
3305:
3296:
3295:
3291:
3253:
3252:
3248:
3238:
3237:
3224:
3178:
3177:
3173:
3127:
3126:
3122:
3100:
3099:
3095:
3073:
3072:
3068:
3045:
3044:
3040:
3026:
3016:
3011:10.1.1.372.4223
3002:
3001:
2997:
2975:
2974:
2970:
2930:
2929:
2925:
2887:
2886:
2882:
2877:Wayback Machine
2868:
2864:
2834:
2833:
2829:
2799:
2798:
2794:
2764:
2763:
2759:
2713:
2712:
2708:
2678:
2677:
2673:
2637:
2636:
2632:
2584:
2583:
2579:
2535:
2534:
2530:
2486:
2485:
2481:
2476:
2472:
2462:
2460:
2456:
2449:
2445:
2444:
2440:
2430:
2428:
2419:
2418:
2414:
2376:
2375:
2371:
2361:
2359:
2354:. 10 May 2017.
2346:
2345:
2341:
2331:
2329:
2316:
2315:
2311:
2303:
2260:
2259:
2255:
2215:
2214:
2210:
2203:
2190:
2189:
2182:
2152:
2151:
2147:
2137:
2135:
2122:
2121:
2117:
2107:
2105:
2092:
2091:
2087:
2073:
2071:
2056:
2048:
2046:
2042:
1998:
1997:
1993:
1945:
1944:
1940:
1912:10.1038/nrn3111
1893:
1892:
1888:
1875:
1868:
1860:
1859:
1850:
1847:
1842:
1829:
1828:
1819:
1815:
1810:
1776:
1772:Substance abuse
1762:Self medication
1737:
1700:
1692:organized crime
1681:
1660:
1491:Alaskan Native
1430:Race/Ethnicity
1414:
1409:
1382:methamphetamine
1350:
1339:
1333:
1330:
1319:
1306:
1302:
1295:
1248:
1234:
1213:
1204:
1179:
1150:
1064:benzodiazepines
1056:benzodiazepines
1043:Pills Anonymous
1019:
975:
863:
858:
849:
834:locus coeruleus
832:pathway in the
823:
812:stress hormones
753:gene expression
745:drug dependence
713:
708:
628:
549:Benzodiazepines
383:
370:
342:
340:Drug withdrawal
336:
327:
227:drug withdrawal
185:biopsychosocial
159:substance abuse
80:drug dependence
57:Drug dependence
44:
39:
36:Substance abuse
28:
23:
22:
15:
12:
11:
5:
5411:
5409:
5401:
5400:
5395:
5385:
5384:
5378:
5377:
5375:
5374:
5363:
5360:
5359:
5357:
5356:
5351:
5350:
5349:
5339:
5338:
5337:
5327:
5322:
5317:
5312:
5307:
5302:
5296:
5294:
5290:
5289:
5286:
5285:
5283:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5241:
5240:
5230:
5224:
5222:
5220:Harm reduction
5216:
5215:
5213:
5212:
5207:
5201:
5199:
5198:Support groups
5195:
5194:
5192:
5191:
5186:
5185:
5184:
5179:
5169:
5164:
5159:
5154:
5153:
5152:
5141:
5139:
5133:
5132:
5130:
5129:
5124:
5119:
5114:
5109:
5104:
5103:
5102:
5097:
5086:
5084:
5078:
5077:
5075:
5074:
5069:
5063:
5061:
5060:Detoxification
5054:
5044:
5043:
5040:
5039:
5037:
5036:
5035:
5034:
5026:
5025:
5024:
5019:
5014:
5009:
5004:
4999:
4997:Benzodiazepine
4994:
4989:
4984:
4975:
4973:
4969:
4968:
4966:
4965:
4960:
4955:
4950:
4944:
4942:
4935:
4929:
4928:
4925:
4924:
4922:
4921:
4920:
4919:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4879:
4872:
4865:
4860:
4847:
4846:
4845:
4844:
4839:
4834:
4829:
4824:
4819:
4806:
4804:
4798:
4797:
4795:
4794:
4789:
4784:
4783:
4782:
4777:
4769:
4768:
4767:
4762:
4754:
4752:Palatable food
4749:
4748:
4747:
4742:
4733:
4731:
4725:
4724:
4722:
4721:
4716:
4711:
4706:
4701:
4696:
4691:
4685:
4683:
4676:
4670:
4669:
4656:
4654:
4653:
4646:
4639:
4631:
4622:
4621:
4619:
4618:
4613:
4612:
4611:
4597:
4595:
4591:
4590:
4588:
4587:
4586:
4585:
4583:Inhalant abuse
4580:
4572:
4571:
4570:
4565:
4555:
4553:
4545:
4544:
4542:
4541:
4540:
4539:
4525:
4524:
4523:
4514:
4512:
4506:
4505:
4503:
4502:
4501:
4500:
4492:
4491:
4490:
4476:
4475:
4474:
4469:
4460:
4459:
4458:
4453:
4443:benzodiazepine
4439:
4438:
4437:
4428:
4426:
4415:
4414:
4412:
4411:
4410:
4409:
4400:
4399:
4398:
4392:
4386:
4380:
4375:
4366:
4364:
4358:
4357:
4355:
4354:
4353:
4352:
4344:
4343:
4342:
4337:
4332:
4322:
4320:
4314:
4313:
4311:
4310:
4309:
4308:
4302:
4293:
4291:
4285:
4284:
4282:
4281:
4280:
4279:
4271:
4270:
4269:
4263:
4254:
4252:
4246:
4245:
4243:
4242:
4241:
4240:
4235:
4229:
4221:
4220:
4219:
4214:
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4199:
4197:
4191:
4190:
4188:
4187:
4186:
4185:
4177:
4176:
4175:
4170:
4165:
4160:
4151:
4149:
4143:
4142:
4139:
4138:
4136:
4135:
4133:Binge drinking
4130:
4123:
4121:
4117:
4116:
4113:
4112:
4110:
4109:
4104:
4098:
4096:
4090:
4089:
4087:
4086:
4080:
4074:
4068:
4063:
4057:
4056:
4055:
4049:
4038:
4033:
4028:
4022:
4020:
4012:
4011:
4009:
4008:
4003:
3998:
3991:
3989:
3981:
3980:
3978:
3977:
3970:
3968:
3962:
3961:
3959:
3958:
3952:
3951:
3950:
3945:
3933:
3931:
3925:
3924:
3922:
3921:
3915:
3909:
3907:
3898:
3891:
3885:
3884:
3882:
3881:
3880:
3879:
3870:
3869:
3868:
3859:
3857:
3851:
3850:
3848:
3847:
3846:
3845:
3832:
3818:
3817:
3816:
3815:
3814:
3808:
3797:
3792:
3777:
3775:
3771:
3770:
3762:
3760:
3759:
3752:
3745:
3737:
3731:
3730:
3702:
3695:
3690:
3684:
3679:
3674:
3665:
3664:
3661:
3660:
3649:
3630:
3609:
3604:
3603:
3601:
3600:Classification
3593:
3592:External links
3590:
3588:
3587:
3562:
3537:
3508:
3471:
3447:
3421:
3385:
3378:
3360:
3353:
3331:
3328:. 8 June 2020.
3315:
3289:
3246:
3222:
3171:
3120:
3109:(4): 391–403.
3093:
3066:
3038:
3029:|journal=
2995:
2984:(3): 335–350.
2968:
2939:(4): 367–384.
2923:
2880:
2862:
2827:
2792:
2757:
2706:
2687:(1–3): 121–8.
2671:
2650:(4): 295–300.
2630:
2591:Brain Research
2577:
2528:
2499:(8): 1149–59.
2479:
2470:
2438:
2412:
2369:
2339:
2309:
2273:(4): 363–371.
2253:
2228:(4): 431–443.
2208:
2201:
2180:
2145:
2115:
2085:
2080:Microsoft Bing
2068:Microsoft Word
2040:
2011:(7): 1109–22.
1991:
1938:
1906:(11): 623–37.
1886:
1866:
1840:
1816:
1814:
1811:
1809:
1808:
1803:
1798:
1793:
1788:
1782:
1779:Questionnaires
1775:
1774:
1769:
1764:
1759:
1754:
1749:
1747:Dual diagnosis
1744:
1738:
1736:
1733:
1699:
1696:
1659:
1656:
1645:
1644:
1641:
1638:
1635:
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1629:
1625:
1624:
1621:
1618:
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1439:
1435:
1434:
1431:
1413:
1410:
1408:
1405:
1352:
1351:
1316:of the subject
1314:worldwide view
1309:
1307:
1300:
1294:
1291:
1290:
1289:
1267:
1247:
1244:
1233:
1230:
1212:
1209:
1203:
1200:
1178:
1175:
1149:
1146:
1074:agent such as
1066:or a taper of
1018:
1015:
987:harm reduction
974:
971:
970:
969:
963:
960:
953:
947:
940:
933:
926:
920:
914:
891:
885:
862:
859:
857:
854:
847:
822:
819:
800:opioid peptide
774:activates the
765:reward pathway
735:" (CREB). The
712:
709:
707:
704:
701:
700:
697:
691:
690:
687:
681:
680:
677:
671:
670:
667:
661:
660:
657:
651:
650:
647:
641:
640:
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617:
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611:
608:
602:
601:
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592:
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573:
570:
564:
563:
560:
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551:
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538:
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532:
526:
525:
522:
519:
516:
513:
507:
506:
503:
500:
497:
494:
488:
487:
484:
481:
478:
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469:
468:
465:
462:
459:
456:
450:
449:
446:
443:
440:
437:
427:
426:
423:
420:
417:
414:
400:An article in
382:
379:
369:
366:
338:Main article:
335:
332:
329:
328:
326:
325:
318:
311:
303:
300:
299:
298:
297:
289:
281:
273:
264:
255:
247:
231:
223:
211:
203:
201:reward systems
196:addictive drug
192:
173:
172:
102:addictive drug
93:drug addiction
71:
70:
65:
59:
58:
55:
51:
50:
42:
26:
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14:
13:
10:
9:
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5258:
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5253:
5251:
5248:
5246:
5243:
5239:
5236:
5235:
5234:
5233:Drug checking
5231:
5229:
5226:
5225:
5223:
5221:
5217:
5211:
5208:
5206:
5203:
5202:
5200:
5196:
5190:
5187:
5183:
5180:
5178:
5175:
5174:
5173:
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5118:
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5105:
5101:
5098:
5096:
5093:
5092:
5091:
5088:
5087:
5085:
5079:
5073:
5070:
5068:
5065:
5064:
5062:
5058:
5055:
5053:
5045:
5033:
5030:
5029:
5027:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4979:
4977:
4976:
4974:
4970:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4945:
4943:
4939:
4936:
4934:
4930:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4884:
4880:
4878:
4877:
4873:
4871:
4870:
4866:
4864:
4861:
4859:
4858:
4854:
4853:
4852:
4849:
4848:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4817:
4813:
4812:
4811:
4808:
4807:
4805:
4799:
4793:
4790:
4788:
4785:
4781:
4778:
4776:
4773:
4772:
4770:
4766:
4763:
4761:
4758:
4757:
4755:
4753:
4750:
4746:
4743:
4741:
4738:
4737:
4735:
4734:
4732:
4730:
4726:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4686:
4684:
4680:
4677:
4675:
4671:
4667:
4663:
4659:
4658:Reinforcement
4652:
4647:
4645:
4640:
4638:
4633:
4632:
4629:
4617:
4614:
4610:
4607:
4606:
4604:
4603:
4599:
4598:
4596:
4592:
4584:
4581:
4579:
4576:
4575:
4573:
4569:
4566:
4563:
4560:
4559:
4557:
4556:
4554:
4552:
4546:
4538:
4535:
4534:
4532:
4530:
4526:
4522:
4519:
4518:
4516:
4515:
4513:
4511:
4507:
4499:
4496:
4495:
4493:
4489:
4486:
4485:
4483:
4481:
4477:
4473:
4470:
4467:
4464:
4463:
4461:
4457:
4454:
4452:
4449:
4448:
4446:
4444:
4440:
4436:
4433:
4432:
4430:
4429:
4427:
4425:
4420:
4416:
4407:
4404:
4403:
4401:
4396:
4393:
4390:
4387:
4384:
4381:
4379:
4376:
4374:
4371:
4370:
4368:
4367:
4365:
4363:
4359:
4351:
4348:
4347:
4345:
4341:
4338:
4336:
4333:
4330:
4327:
4326:
4324:
4323:
4321:
4319:
4315:
4306:
4303:
4301:
4298:
4297:
4295:
4294:
4292:
4290:
4286:
4278:
4275:
4274:
4272:
4267:
4264:
4262:
4259:
4258:
4256:
4255:
4253:
4251:
4247:
4239:
4236:
4233:
4230:
4228:
4225:
4224:
4222:
4218:
4215:
4212:
4209:
4207:
4204:
4203:
4201:
4200:
4198:
4196:
4192:
4184:
4181:
4180:
4178:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4155:
4153:
4152:
4150:
4148:
4144:
4134:
4131:
4128:
4125:
4124:
4122:
4118:
4108:
4105:
4103:
4100:
4099:
4097:
4095:
4091:
4084:
4081:
4078:
4075:
4072:
4069:
4067:
4064:
4061:
4058:
4053:
4050:
4048:
4045:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4023:
4021:
4019:
4013:
4007:
4004:
4002:
3999:
3996:
3993:
3992:
3990:
3988:
3982:
3975:
3972:
3971:
3969:
3967:
3963:
3956:
3953:
3949:
3946:
3944:
3941:
3940:
3938:
3935:
3934:
3932:
3930:
3926:
3919:
3916:
3914:
3911:
3910:
3908:
3906:
3902:
3899:
3895:
3892:
3890:
3886:
3877:
3874:
3873:
3871:
3867:
3864:
3863:
3861:
3860:
3858:
3856:substance use
3852:
3844:
3840:
3836:
3833:
3831:
3827:
3824:
3823:
3822:
3819:
3812:
3809:
3807:
3804:
3803:
3801:
3798:
3796:
3793:
3791:
3790:Drug overdose
3787:
3784:
3783:
3782:
3779:
3778:
3776:
3772:
3768:
3765:
3758:
3753:
3751:
3746:
3744:
3739:
3738:
3735:
3729:
3715:
3711:
3707:
3703:
3700:
3696:
3694:
3691:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3669:
3659:
3655:
3654:
3650:
3648:
3644:
3640:
3639:
3635:
3631:
3628:
3624:
3620:
3619:
3615:
3611:
3610:
3607:
3602:
3598:
3591:
3576:
3572:
3566:
3563:
3551:
3547:
3541:
3538:
3526:
3519:
3512:
3509:
3493:
3489:
3482:
3475:
3472:
3468:
3462:
3460:
3458:
3456:
3454:
3452:
3448:
3443:
3439:
3435:
3431:
3425:
3422:
3409:
3405:
3401:
3394:
3392:
3390:
3386:
3381:
3375:
3371:
3364:
3361:
3356:
3350:
3347:. Macmillan.
3345:
3344:
3335:
3332:
3327:
3326:
3319:
3316:
3303:
3299:
3293:
3290:
3285:
3281:
3277:
3273:
3269:
3265:
3262:(2): 158–64.
3261:
3257:
3250:
3247:
3242:
3235:
3233:
3231:
3229:
3227:
3223:
3218:
3214:
3209:
3204:
3199:
3194:
3190:
3186:
3182:
3175:
3172:
3167:
3163:
3158:
3153:
3148:
3143:
3139:
3135:
3131:
3124:
3121:
3116:
3112:
3108:
3104:
3097:
3094:
3089:
3085:
3082:(2): 90–100.
3081:
3077:
3070:
3067:
3062:
3058:
3054:
3050:
3042:
3039:
3034:
3021:
3012:
3007:
2999:
2996:
2991:
2987:
2983:
2979:
2972:
2969:
2964:
2960:
2955:
2950:
2946:
2942:
2938:
2934:
2927:
2924:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2884:
2881:
2878:
2874:
2871:
2866:
2863:
2858:
2854:
2850:
2846:
2842:
2838:
2831:
2828:
2823:
2819:
2815:
2811:
2807:
2803:
2796:
2793:
2788:
2784:
2780:
2776:
2772:
2768:
2761:
2758:
2753:
2749:
2744:
2739:
2734:
2729:
2725:
2721:
2717:
2710:
2707:
2702:
2698:
2694:
2690:
2686:
2682:
2675:
2672:
2667:
2663:
2658:
2653:
2649:
2645:
2641:
2634:
2631:
2627:
2622:
2618:
2613:
2608:
2604:
2600:
2596:
2592:
2588:
2581:
2578:
2573:
2569:
2564:
2559:
2555:
2551:
2547:
2543:
2539:
2532:
2529:
2524:
2520:
2515:
2510:
2506:
2502:
2498:
2494:
2490:
2483:
2480:
2474:
2471:
2455:
2448:
2442:
2439:
2426:
2422:
2416:
2413:
2408:
2404:
2400:
2396:
2392:
2388:
2384:
2380:
2373:
2370:
2357:
2353:
2349:
2343:
2340:
2327:
2323:
2319:
2313:
2310:
2306:
2298:
2294:
2289:
2284:
2280:
2276:
2272:
2268:
2264:
2257:
2254:
2250:
2245:
2241:
2236:
2231:
2227:
2223:
2219:
2212:
2209:
2204:
2202:9780071481274
2198:
2194:
2187:
2185:
2181:
2176:
2172:
2168:
2164:
2160:
2156:
2149:
2146:
2133:
2129:
2125:
2119:
2116:
2103:
2099:
2095:
2089:
2086:
2081:
2069:
2065:
2064:
2055:
2051:
2044:
2041:
2036:
2032:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1995:
1992:
1988:
1983:
1979:
1974:
1969:
1965:
1961:
1957:
1953:
1949:
1942:
1939:
1935:
1931:
1927:
1922:
1917:
1913:
1909:
1905:
1901:
1897:
1890:
1887:
1884:
1880:
1879:
1873:
1871:
1867:
1863:
1857:
1853:
1843:
1841:9780071481274
1837:
1833:
1826:
1824:
1822:
1818:
1812:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1783:
1781:
1780:
1773:
1770:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1739:
1734:
1732:
1729:
1723:
1721:
1717:
1711:
1709:
1705:
1698:United States
1697:
1695:
1693:
1689:
1684:
1679:
1677:
1672:
1667:
1665:
1657:
1655:
1652:
1642:
1639:
1636:
1633:
1630:
1627:
1626:
1622:
1619:
1616:
1613:
1610:
1607:
1606:
1602:
1599:
1596:
1593:
1590:
1587:
1586:
1582:
1579:
1576:
1573:
1570:
1567:
1566:
1560:
1551:
1548:
1545:
1544:
1540:
1537:
1534:
1533:
1529:
1526:
1524:12 and older
1523:
1522:
1518:
1515:
1512:
1511:
1505:
1504:
1494:
1492:
1488:
1487:
1483:
1481:
1477:
1476:
1472:
1469:
1468:
1464:
1461:
1460:
1456:
1453:
1452:
1448:
1445:
1444:
1440:
1437:
1436:
1432:
1429:
1428:
1422:
1420:
1411:
1406:
1404:
1400:
1398:
1393:
1388:
1385:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1348:
1345:
1337:
1334:February 2014
1327:
1323:
1317:
1315:
1308:
1299:
1298:
1292:
1287:
1283:
1279:
1275:
1271:
1268:
1265:
1261:
1257:
1254:is an active
1253:
1250:
1249:
1245:
1243:
1240:
1231:
1229:
1226:
1222:
1219:
1210:
1208:
1201:
1199:
1197:
1191:
1186:
1184:
1176:
1174:
1171:
1167:
1163:
1159:
1155:
1147:
1145:
1143:
1142:disease model
1139:
1135:
1129:
1127:
1123:
1122:buprenorphine
1119:
1115:
1111:
1107:
1102:
1098:
1097:alpha-agonist
1094:
1089:
1085:
1081:
1077:
1073:
1072:antiepileptic
1069:
1068:phenobarbital
1065:
1061:
1057:
1052:
1048:
1044:
1040:
1036:
1032:
1027:
1025:
1016:
1014:
1012:
1008:
1004:
998:
994:
990:
988:
984:
980:
972:
968:
964:
961:
958:
957:Phencyclidine
954:
952:
948:
945:
941:
938:
934:
931:
927:
925:
921:
919:
915:
912:
908:
904:
900:
896:
892:
890:
886:
884:
880:
879:
878:
876:
872:
868:
860:
855:
853:
850:
843:
835:
831:
820:
818:
815:
813:
809:
808:reward system
805:
801:
797:
793:
789:
785:
781:
777:
768:
766:
762:
758:
754:
750:
746:
743:component of
742:
741:psychological
738:
734:
730:
726:
722:
718:
710:
705:
698:
696:
693:
692:
688:
686:
683:
682:
678:
676:
673:
672:
668:
666:
663:
662:
658:
656:
653:
652:
648:
646:
643:
642:
638:
635:
634:
631:
626:Capture rates
625:
618:
615:
612:
609:
607:
604:
603:
599:
596:
593:
590:
588:
585:
584:
580:
577:
574:
571:
569:
566:
565:
561:
558:
555:
552:
550:
547:
546:
542:
539:
536:
533:
531:
528:
527:
523:
520:
517:
514:
512:
509:
508:
504:
501:
498:
495:
493:
490:
489:
485:
482:
479:
476:
474:
471:
470:
466:
463:
460:
457:
455:
452:
451:
447:
444:
441:
438:
436:
432:
429:
428:
424:
421:
418:
415:
412:
411:
408:
405:
404:
398:
396:
392:
388:
380:
374:
367:
365:
363:
358:
356:
352:
348:
341:
333:
324:
319:
317:
312:
310:
305:
304:
301:
295:
294:
290:
287:
286:
282:
279:
278:
277:sensitization
274:
271:
269:
265:
262:
260:
256:
253:
252:
248:
245:
241:
237:
236:
232:
229:
228:
224:
221:
217:
216:
212:
209:
208:
204:
202:
198:
197:
193:
190:
186:
182:
181:
177:
176:
174:
169:
166:
164:
160:
156:
151:
147:
143:
142:
137:
134:
130:
126:
121:
119:
115:
111:
107:
103:
99:
95:
94:
89:
85:
81:
77:
69:
66:
64:
60:
56:
52:
47:
41:
37:
33:
19:
4932:
4881:
4874:
4867:
4855:
4814:
4756:Sex-related
4665:
4600:
4527:
4478:
4441:
4289:Hallucinogen
4016:Neurological
3842:
3764:Psychoactive
3718:. Retrieved
3714:the original
3710:apps.who.int
3709:
3651:
3632:
3612:
3578:. Retrieved
3574:
3565:
3553:. Retrieved
3550:usatoday.com
3549:
3540:
3528:. Retrieved
3524:
3511:
3499:. Retrieved
3492:the original
3487:
3474:
3441:
3424:
3412:. Retrieved
3403:
3369:
3363:
3342:
3334:
3324:
3318:
3306:. Retrieved
3302:the original
3292:
3259:
3255:
3249:
3240:
3188:
3184:
3174:
3137:
3133:
3123:
3106:
3102:
3096:
3079:
3075:
3069:
3055:(1): 80–90.
3052:
3048:
3041:
3020:cite journal
2998:
2981:
2977:
2971:
2936:
2932:
2926:
2893:
2889:
2883:
2865:
2843:(1): 75–83.
2840:
2836:
2830:
2808:(3): 251–8.
2805:
2801:
2795:
2770:
2766:
2760:
2723:
2719:
2709:
2684:
2680:
2674:
2647:
2643:
2633:
2624:
2594:
2590:
2580:
2545:
2541:
2531:
2496:
2492:
2482:
2473:
2461:. Retrieved
2454:the original
2441:
2429:. Retrieved
2415:
2382:
2378:
2372:
2360:. Retrieved
2352:sheknows.com
2351:
2342:
2330:. Retrieved
2321:
2312:
2300:
2270:
2266:
2256:
2247:
2225:
2221:
2211:
2192:
2158:
2154:
2148:
2136:. Retrieved
2127:
2118:
2106:. Retrieved
2097:
2088:
2078:– via
2072:. Retrieved
2061:www.who.int
2060:
2043:
2008:
2004:
1994:
1985:
1958:(1): 38–55.
1955:
1951:
1941:
1933:
1903:
1899:
1889:
1876:
1855:
1851:
1845:
1831:
1778:
1777:
1724:
1712:
1701:
1688:drug dealers
1685:
1680:
1668:
1664:jurisdiction
1661:
1648:
1594:un-employed
1588:high school
1557:
1546:18 or older
1503:
1500:
1490:
1479:
1415:
1412:Demographics
1401:
1389:
1386:
1374:biochemistry
1370:agricultural
1355:
1340:
1331:
1311:
1235:
1214:
1205:
1193:
1188:
1180:
1151:
1130:
1028:
1020:
999:
995:
991:
979:drug craving
976:
937:Hallucinogen
864:
824:
816:
788:CRF receptor
769:
721:neuropeptide
714:
629:
492:Barbiturates
401:
399:
390:
386:
384:
368:Risk factors
359:
343:
291:
283:
275:
266:
257:
249:
233:
225:
219:
213:
206:
205:
194:
178:
145:
139:
122:
101:
91:
79:
75:
74:
40:
5081:Behavioral
4992:Barbiturate
4987:Amphetamine
4765:Pornography
4760:Intercourse
4694:Amphetamine
4660:disorders:
4529:amphetamine
4480:barbiturate
3720:26 February
3488:www.arc.gov
2332:21 December
1658:Legislation
1470:Mixed race
1368:"). Modern
1183:acupuncture
1136:41% of the
1017:Residential
639:% of users
568:Amphetamine
259:reinforcing
133:behavioural
110:reinforcing
54:Other names
5387:Categories
5305:Allen Carr
5145:Drug rehab
5136:Treatment
5052:management
5048:Treatment
4982:Alcoholism
4963:Withdrawal
4933:Dependence
4851:Epigenetic
4803:mechanisms
4736:Financial
4729:Behavioral
4666:dependence
4510:Stimulants
4173:Caffeinism
4127:Alcoholism
3800:Withdrawal
3580:2 November
3530:1 November
3501:1 November
3438:"Drug Use"
3434:Roser, Max
3308:27 October
2954:1903/25227
1856:withdrawal
1852:Dependence
1813:References
1671:substances
1634:full-time
1614:part-time
1358:phenomenon
1282:antibodies
1260:norcocaine
1225:disulfiram
1196:psilocybin
1101:loperamide
1080:pregabalin
1076:gabapentin
1051:counseling
973:Management
946:dependence
939:dependence
903:anxiolytic
796:enkephalin
403:The Lancet
334:Withdrawal
207:dependence
98:compulsive
88:withdrawal
68:Psychiatry
5083:therapies
4972:Disorders
4674:Addiction
4662:addiction
4616:Chocolate
4018:disorders
3414:3 January
3006:CiteSeerX
2963:1476-7392
2767:Addiction
2175:0950-4125
2128:BehaveNet
2098:BehaveNet
1462:Hispanic
1326:talk page
1118:methadone
1114:oxycodone
1093:clonidine
1084:valproate
1007:hepatitis
856:Diagnosis
757:dynorphin
293:tolerance
268:rewarding
180:addiction
106:rewarding
63:Specialty
5372:Category
5293:See also
5138:programs
5017:Nicotine
5007:Cannabis
5002:Caffeine
4941:Concepts
4801:Cellular
4745:Shopping
4740:Gambling
4714:Nicotine
4549:Volatile
4424:hypnotic
4419:Sedative
4318:Nicotine
4195:Cannabis
4147:Caffeine
4006:Hangover
3854:Combined
3408:Archived
3284:22415520
3276:16038686
3217:27053944
3166:27053944
2918:27080462
2873:Archived
2857:16782286
2822:15734225
2752:24904419
2701:15464026
2621:26740398
2597:: 71–4.
2572:18675281
2523:17671276
2431:18 April
2425:Archived
2399:17382831
2362:28 April
2356:Archived
2326:Archived
2297:26816013
2244:24459410
2132:Archived
2102:Archived
2035:21459101
1982:22641964
1930:21989194
1735:See also
1392:Morphine
1378:fentanyl
1320:You may
1286:nicotine
1246:Vaccines
1239:Suboxone
1218:Pavlov's
1138:variance
1110:dilaudid
1088:baclofen
944:Inhalant
899:hypnotic
895:Sedative
761:dopamine
655:Caffeine
645:Cannabis
587:Cannabis
530:Ketamine
435:Morphine
419:Pleasure
136:disorder
5012:Cocaine
4699:Cocaine
4689:Alcohol
4594:Related
4551:solvent
4362:Opioids
4250:Cocaine
4043:(AWS):
3985:Nervous
3939:(ALD):
3889:Alcohol
3774:General
3658:D019966
3555:18 July
3208:4822281
3157:4822281
2910:8816054
2787:8081178
2743:4034717
2726:: 116.
2666:8747753
2612:4927417
2563:2635333
2514:2837343
2407:5903121
2322:YouTube
2288:6135257
2235:3898681
2138:12 June
2108:12 June
2074:23 June
2026:3139704
1973:4040958
1921:3272277
1580:Region
1519:Female
1362:history
1293:History
1274:vaccine
1264:cholera
1256:vaccine
1134:explain
983:seeking
965:305.10
955:304.90
949:304.80
942:304.60
935:304.50
928:304.40
922:304.30
916:304.20
893:304.10
887:304.00
881:303.90
695:Tobacco
675:Cocaine
665:Alcohol
606:Ecstasy
511:Alcohol
473:Tobacco
454:Cocaine
270:stimuli
261:stimuli
240:somatic
189:alcohol
150:alcohol
5022:Opioid
4978:Drugs
4904:HDAC10
4719:Opioid
4605:: SUD
4564:(SSDS)
4307:(HPPD)
4062:(FASD)
3813:(PAWS)
3376:
3351:
3282:
3274:
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3205:
3191:: 16.
3164:
3154:
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3008:
2961:
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2397:
2379:Lancet
2295:
2285:
2242:
2232:
2199:
2173:
2033:
2023:
1980:
1970:
1928:
1918:
1838:
1718:, the
1597:15.2%
1583:Rates
1577:Rates
1571:Rates
1549:11.4%
1535:12-17
1527:10.8%
1495:14.9%
1484:11.3%
1473:10.9%
1454:White
1446:Black
1438:Asian
1364:(see "
1270:TA-NIC
1266:toxin.
1164:; (2)
1106:heroin
1099:, and
1041:, and
875:DSM-IV
867:DSM-IV
719:: the
699:31.9%
689:23.1%
685:Heroin
679:16.7%
669:15.4%
431:Heroin
146:DSM-IV
129:mental
4914:SIRT2
4909:SIRT1
4899:HDAC9
4894:HDAC5
4889:HDAC4
4883:HDAC3
4876:HDAC2
4869:HDAC1
4842:NF-ÎşB
4837:GluR2
4822:c-Fos
4816:ΔFosB
4468:(BUD)
4408:(OUD)
4397:(OIC)
4391:(OIE)
4385:(OIH)
4331:(GTS)
4268:(PCE)
4234:(CUD)
4213:(CHS)
4073:(PAN)
4054:(DTs)
3997:(ARD)
3976:(AKA)
3957:(ABS)
3920:(AFR)
3878:(CDI)
3521:(PDF)
3495:(PDF)
3484:(PDF)
3280:S2CID
2914:S2CID
2463:6 May
2457:(PDF)
2450:(PDF)
2403:S2CID
2057:(PDF)
2047:Drs;
1674:is a
1643:6.6%
1637:9.5%
1631:0.9%
1623:8.4%
1617:9.3%
1611:2.1%
1603:8.6%
1591:2.5%
1552:5.8%
1541:5.2%
1538:5.3%
1530:5.8%
1516:Male
1465:8.6%
1457:8.4%
1449:7.4%
1441:4.6%
1366:Opium
1278:TA-CD
1252:TA-CD
1112:, or
1095:, an
1082:, or
901:, or
534:1.54
155:DSM-5
114:ΔFosB
5050:and
4832:CREB
4827:Cdk5
4682:Drug
4664:and
4574:SUD
4558:SID
4533:SUD
4517:SID
4494:SUD
4484:SID
4462:SUD
4447:SID
4431:SID
4402:SUD
4369:SID
4346:SUD
4325:SID
4296:SID
4273:SUD
4257:SID
4223:SUD
4202:SID
4179:SUD
4154:SID
4085:(WE)
3872:SID
3862:SUD
3722:2015
3653:MeSH
3638:9-CM
3582:2018
3557:2019
3532:2018
3503:2018
3416:2014
3374:ISBN
3349:ISBN
3310:2009
3272:PMID
3213:PMID
3162:PMID
3033:help
2959:ISSN
2906:PMID
2853:PMID
2818:PMID
2783:PMID
2748:PMID
2697:PMID
2662:PMID
2617:PMID
2595:1645
2568:PMID
2519:PMID
2465:2014
2433:2014
2395:PMID
2364:2018
2334:2020
2293:PMID
2240:PMID
2197:ISBN
2171:ISSN
2140:2015
2110:2015
2076:2021
2031:PMID
1978:PMID
1926:PMID
1836:ISBN
1649:The
1513:Age
1380:and
1356:The
1009:and
1003:AIDS
909:and
838:CREB
827:cAMP
636:Drug
619:0.7
610:1.13
600:0.8
591:1.51
581:1.1
572:1.67
562:1.8
553:1.83
543:1.0
540:1.7
537:1.9
524:1.6
515:1.93
505:1.8
496:2.01
486:1.8
477:2.21
467:1.3
458:2.39
448:3.0
439:3.00
416:Mean
413:Drug
385:The
183:– a
131:and
123:The
116:, a
108:and
4918:...
4857:G9a
4120:SUD
3897:SID
3821:SUD
3781:SID
3728:pdf
3647:304
3643:303
3634:ICD
3627:F19
3625:.2-
3623:F10
3614:ICD
3264:doi
3203:PMC
3193:doi
3152:PMC
3142:doi
3111:doi
3084:doi
3057:doi
2986:doi
2949:hdl
2941:doi
2898:doi
2845:doi
2810:doi
2775:doi
2738:PMC
2728:doi
2689:doi
2685:500
2652:doi
2607:PMC
2599:doi
2558:PMC
2550:doi
2509:PMC
2501:doi
2497:164
2387:doi
2383:369
2283:PMC
2275:doi
2271:374
2230:PMC
2163:doi
2021:PMC
2013:doi
1968:PMC
1960:doi
1916:PMC
1908:doi
1502:17.
1120:or
989:".
836:by
772:CRF
659:9%
649:9%
616:1.2
613:1.5
597:1.7
594:1.9
578:1.9
575:2.0
559:2.1
556:1.7
521:1.9
518:2.3
502:2.2
499:2.0
483:2.6
480:2.3
464:2.8
461:3.0
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