917:
40:
1433:
690:
1313:
2905:-1 provided the initial connection and indicated that these molecules might control infection as part of immune responses in vivo, and that sustained delivery of such inhibitors have the capacity of long-term infection control. The association of chemokine production with antigen-induced proliferative responses, more favorable clinical status in
1217:. A typical example is CXCL-8, which acts as a chemoattractant for neutrophils. In contrast to the homeostatic chemokine receptors, there is significant promiscuity (redundancy) associated with binding receptor and inflammatory chemokines. This often complicates research on receptor-specific therapeutics in this area.
822:
that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as
2816:
residue that allow formation of a disulfide bridge between these loops. G proteins are coupled to the C-terminal end of the chemokine receptor to allow intracellular signaling after receptor activation, while the N-terminal domain of the chemokine receptor determines ligand binding specificity.
3327:
Xie JH, Nomura N, Lu M, Chen SL, Koch GE, Weng Y, Rosa R, Di Salvo J, Mudgett J, Peterson LB, Wicker LS, DeMartino JA (June 2003). "Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation".
2703:
The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has only two cysteines; one N-terminal cysteine and one cysteine downstream. Two chemokines have been described for this subgroup and are called XCL1
2565:
Members of the chemokine family are divided into four groups depending on the spacing of their first two cysteine residues. Thus the nomenclature for chemokines is, e.g.: CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor.
1380:, beginning with a signal peptide of approximately 20 amino acids that gets cleaved from the active (mature) portion of the molecule during the process of its secretion from the cell. The first two cysteines, in a chemokine, are situated close together near the
924:
The major role of chemokines is to act as a chemoattractant to guide the migration of cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Some chemokines control cells of the
2598:. Chemokines of this subfamily usually contain four cysteines (C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1, CCL15, CCL21, CCL23 and CCL28. CC chemokines induce the migration of
3482:
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T (August 2011).
2663:) are separated by one amino acid, represented in this name with an "X". There have been 17 different CXC chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of
1247:: the four key chemokines that are involved in the recruitment of T lymphocytes to the site of inflammation are: CCL2, CCL1, CCL22 and CCL17. Furthermore, CXCR3 expression by T-cells is induced following
2675:(or ELR for short) immediately before the first cysteine of the CXC motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive CXC chemokines specifically induce the migration of
826:
Cytokine proteins are classified as chemokines according to behavior and structural characteristics. In addition to being known for mediating chemotaxis, chemokines are all approximately 8–10
1376:
typically join the first to third, and the second to fourth cysteine residues, numbered as they appear in the protein sequence of the chemokine. Typical chemokine proteins are produced as
4922:
2909:
infection, as well as with an uninfected status in subjects at risk for infection suggests a positive role for these molecules in controlling the natural course of HIV infection.
920:
Chemokines released by infected or damaged cells form a concentration gradient. Attracted cells move through the gradient towards the higher concentration of chemokine.
4311:
3586:
1334:
Proteins are classified into the chemokine family based on their structural characteristics, not just their ability to attract cells. All chemokines are small, with a
155:
2773:. Approximately 19 different chemokine receptors have been characterized to date, which are divided into four families depending on the type of chemokine they bind;
3544:
4915:
1279:: the migration of eosinophils into various tissues involved several chemokines of CC family: CCL11, CCL24, CCL26, CCL5, CCL7, CCL13, and CCL3. Chemokines
896:
Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and C. All of these proteins exert their biological effects by interacting with
2687:(IL-8), which induces neutrophils to leave the bloodstream and enter into the surrounding tissue. Other CXC chemokines that lack the ELR motif, such as
945:
chemokines and are produced and secreted without any need to stimulate their source cells. Some chemokines have roles in development; they promote
4387:
2838:
1299:: are regulated primarily by CXC chemokines. An example CXCL8 (IL-8) is chemoattractant for neutrophils and also activating their metabolic and
1209:
or injury and determine the migration of inflammatory leukocytes into the damaged area. Typical inflammatory chemokines include: CCL2, CCL3 and
5670:
4908:
4782:
103:
1159:
and on lymphatic endothelial cells) and their receptor CCR7 (expressed on cells destined for homing in cells to these organs). Using these
3773:
2740:
CL1). It is both secreted and tethered to the surface of the cell that expresses it, thereby serving as both a chemoattractant and as an
3807:
1251:
and activated T-cells are attracted to sites of inflammation where the IFN-y inducible chemokines CXCL9, CXCL10 and CXCL11 are secreted.
4673:
773:
3779:
3284:
Graham GJ, Locati M (January 2013). "Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6".
1155:
and lymphoid tissues. Their homeostatic function in homing is best exemplified by the chemokines CCL19 and CCL21 (expressed within
1235:: the key chemokines that attract these cells to the site of inflammation include: CCL2, CCL3, CCL5, CCL7, CCL8, CCL13, CCL17 and
2789:
that binds the two XC chemokines (XCL1 and XCL2). They share many structural features; they are similar in size (with about 350
3704:
Garzino-Demo A, Moss RB, Margolick JB, Cleghorn F, Sill A, Blattner WA, Cocchi F, Carlo DJ, DeVico AL, Gallo RC (October 1999).
5881:
5872:
4203:
2898:
1291:
on the surface of eosinophils, and eotaxin plays an essential role in the initial recruitment of eosinophils into the lesion.
711:
175:
5794:
5675:
5362:
3980:
2812:
residues important for receptor regulation. The first two extracellular loops of chemokine receptors each has a conserved
1432:
5980:
754:
3572:
4816:
4366:
4141:
726:
3602:"Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells"
2724:
A fourth group has also been discovered and members have three amino acids between the two cysteines and is termed CX
4849:
4651:
4361:
3706:"Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status"
2829:
following ligand binding. Activation of G proteins, by chemokine receptors, causes the subsequent activation of an
2762:
2617:(MCP-1 or CCL2) which induces monocytes to leave the bloodstream and enter the surrounding tissue to become tissue
707:
1384:
of the mature protein, with the third cysteine residing in the centre of the molecule and the fourth close to the
953:), or guide cells to tissues that provide specific signals critical for cellular maturation. Other chemokines are
700:
4770:
4455:
3155:
Zlotnik A, Burkhardt AM, Homey B (August 2011). "Homeostatic chemokine receptors and organ-specific metastasis".
1171:
include: CCR9, CCR10, and CXCR5, which are important as part of the cell addresses for tissue-specific homing of
733:
4805:
4232:
4208:
1164:
163:
1259:: on their surface express several receptors for chemokines: CCR1, CCR2, CCR3, CCR4, CCR5, CXCR2, and CXCR4.
5438:
3800:
2774:
2692:
2680:
1168:
938:
3045:
2586:. There have been at least 27 distinct members of this subgroup reported for mammals, called CC chemokine
1001:
or tissue damage. Certain inflammatory chemokines activate cells to initiate an immune response or promote
740:
4942:
4133:
2878:
2778:
2633:
1138:
1128:
1010:
901:
790:
3580:
2846:
2587:
874:
873:
and are involved in controlling the migration of cells during normal processes of tissue maintenance or
1263:
of these receptors CCL2 and CCL5 play an important role in mast cell recruitment and activation in the
916:
159:
722:
5823:
4659:
3717:
3613:
3496:
2918:
1006:
116:
4501:
2766:
1064:. This classification is not strict; for example, CCL20 can act also as pro-inflammatory chemokine.
5975:
5950:
5557:
4934:
4931:
4668:
4625:
4540:
4383:
4247:
3793:
3735:
3637:
3353:
3309:
3180:
3134:
3091:
2858:
2758:
2753:
1361:
1079:
905:
5227:
5597:
5592:
5582:
5577:
5572:
5552:
5497:
5492:
5482:
5467:
3560:
1388:. A loop of approximately ten amino acids follows the first two cysteines and is known as the
1086:) and actively participate in the inflammatory response attracting immune cells to the site of
5799:
5638:
4532:
4151:
4017:
3753:
3686:
3629:
3564:
3522:
3464:
3429:
3425:
3394:
3345:
3301:
3263:
3229:
3172:
3126:
3083:
3075:
3026:
3018:
2979:
2961:
2741:
1377:
1353:
1346:
1248:
182:
150:
5779:
4844:
4765:
4633:
4322:
4156:
3743:
3725:
3676:
3668:
3621:
3556:
3512:
3504:
3456:
3421:
3384:
3337:
3293:
3219:
3211:
3164:
3118:
3065:
3057:
3010:
2969:
2953:
2862:
2854:
2842:
2170:
1167:(APC) to lymph nodes during the adaptive immune response. Among other homeostatic chemokine
39:
142:
4371:
4057:
2834:
2607:
3721:
3617:
3500:
4885:
4880:
4735:
4731:
4713:
4708:
4511:
4506:
4496:
4491:
4486:
4481:
4476:
4472:
4441:
4436:
4431:
4410:
4405:
4400:
4395:
4350:
4345:
4340:
4335:
4283:
4268:
4259:
3816:
3681:
3656:
3517:
3484:
3224:
3199:
2974:
2941:
2853:(DAG) that trigger intracellular signaling events; DAG activates another enzyme called
2826:
2793:), have a short, acidic N-terminal end, seven helical transmembrane domains with three
2583:
1385:
1381:
1373:
1335:
1323:
1070:: these are formed under pathological conditions (on pro-inflammatory stimuli, such as
819:
812:
747:
5969:
5562:
5472:
5150:
4875:
4870:
4865:
4811:
4760:
4426:
4330:
4306:
4301:
4278:
4273:
4264:
4255:
4037:
3748:
3705:
3485:"The ageing systemic milieu negatively regulates neurogenesis and cognitive function"
3249:"Chemokines and chemokine receptors: their manifold roles in homeostasis and disease"
3061:
2870:
2861:
from intracellular stores. These events promote many signaling cascades (such as the
2798:
2794:
2684:
2664:
2244:
1300:
1071:
1002:
978:
926:
862:
108:
45:
3641:
3313:
3184:
3095:
837:
These proteins have historically been known under several other names including the
72:
5924:
5858:
5417:
5222:
5043:
4356:
4188:
3412:
Fernandez EJ, Lolis E (2002). "Structure, function, and inhibition of chemokines".
3357:
3138:
3122:
2709:
2705:
2648:
1243:
1202:
1087:
954:
950:
946:
890:
858:
834:
residues in conserved locations that are key to forming their 3-dimensional shape.
138:
3625:
1195:
promotes proliferation of progenitor B cells in the bone marrow microenvironment.
1005:. They are released by many different cell types and serve to guide cells of both
3600:
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995).
3215:
84:
5892:
5789:
5705:
5690:
5053:
4900:
4777:
4723:
4464:
4223:
4146:
3373:"Chemokines: roles in leukocyte development, trafficking, and effector function"
3109:
Mélik-Parsadaniantz S, Rostène W (July 2008). "Chemokines and neuromodulation".
2957:
2850:
2801:
2733:
2579:
2060:
2018:
1976:
1778:
1728:
1681:
1405:
1401:
1288:
1192:
1188:
1156:
1142:
942:
870:
689:
3710:
Proceedings of the
National Academy of Sciences of the United States of America
1028:: are constitutively produced in certain tissues and are responsible for basal
5809:
5769:
5695:
5237:
4830:
4523:
4213:
4173:
3460:
2874:
2866:
2790:
2676:
2618:
1393:
1369:
1357:
1350:
1318:
1312:
1295:
1275:
1231:
1172:
1134:
990:
934:
930:
878:
827:
3730:
3672:
3079:
3022:
2965:
1342:. They are approximately 20-50% identical to each other; that is, they share
5680:
5648:
5232:
5217:
3785:
3545:"Chemokine receptors and their role in inflammation and infectious diseases"
2809:
2770:
1420:
loops; the third and fourth cysteines are located in the 30s and 50s loops.
1255:
1206:
1176:
1075:
1029:
998:
982:
970:
897:
866:
3757:
3690:
3568:
3526:
3468:
3433:
3398:
3371:
Ono SJ, Nakamura T, Miyazaki D, Ohbayashi M, Dawson M, Toda M (June 2003).
3349:
3305:
3267:
3233:
3176:
3130:
3087:
3030:
2983:
3633:
3389:
3372:
977:. Their release is often stimulated by pro-inflammatory cytokines such as
112:
17:
5945:
5423:
4825:
3820:
3070:
3014:
2882:
2813:
2672:
2629:
2603:
2599:
1365:
1327:
1227:
986:
958:
886:
831:
808:
79:
3508:
3341:
3248:
5247:
3046:"An introduction to chemokines and their roles in transfusion medicine"
2998:
2940:
Raman, Dayanidhi; Sobolik-Delmaire, Tammy; Richmond, Ann (2011-03-10).
2668:
815:
96:
91:
3297:
2999:"The Many Roles of Chemokines and Chemokine Receptors in Inflammation"
5934:
5784:
5774:
5748:
5727:
5633:
5628:
4703:
4600:
4595:
4590:
4585:
4580:
4575:
4293:
4098:
4082:
4077:
4072:
4067:
4062:
4052:
4047:
3739:
2901:) 1α and 1β (now known as CCL5, CCL3 and CCL4 respectively) suppress
2894:
2830:
2805:
2782:
2691:, tend to be chemoattractant for lymphocytes. CXC chemokines bind to
2688:
2625:
2554:
2543:
2439:
2418:
2400:
2382:
2361:
2336:
2311:
2290:
1260:
1184:
1160:
1152:
1115:
1061:
1057:
966:
861:
and can be induced during an immune response to recruit cells of the
170:
3601:
3168:
908:, that are selectively found on the surfaces of their target cells.
670:
664:
658:
651:
645:
639:
633:
627:
621:
615:
609:
603:
597:
591:
585:
579:
573:
567:
561:
555:
549:
543:
537:
531:
525:
519:
513:
507:
501:
495:
489:
483:
477:
471:
465:
459:
453:
447:
441:
435:
429:
423:
417:
411:
405:
399:
393:
387:
381:
375:
369:
363:
357:
351:
345:
339:
333:
327:
321:
315:
309:
303:
297:
291:
285:
279:
273:
267:
261:
255:
249:
243:
237:
231:
225:
219:
213:
207:
200:
194:
188:
2695:, of which seven have been discovered to date, designated CXCR1-7.
981:. Inflammatory chemokines function mainly as chemoattractants for
807: 'movement'), or chemotactic cytokines, are a family of small
5913:
5758:
5737:
5716:
5659:
5623:
5618:
5607:
5547:
5542:
5537:
5532:
5527:
5522:
5507:
5462:
5447:
5398:
5393:
5388:
5377:
5367:
5351:
5341:
5320:
5294:
5289:
5268:
5207:
5202:
5197:
5192:
5140:
5135:
5104:
5099:
5094:
5089:
5084:
5079:
5074:
5033:
5028:
4997:
4992:
4987:
4982:
4739:
4698:
4693:
4688:
4683:
4678:
4615:
4605:
4570:
4565:
4560:
4555:
4550:
4545:
4198:
4193:
4183:
4168:
4163:
4042:
4032:
4027:
4022:
4012:
4007:
4001:
3985:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
2644:
2640:
2429:
2372:
2351:
2347:
2326:
2322:
2301:
2280:
2269:
2259:
2255:
2226:
2216:
2212:
2201:
2191:
2180:
2159:
2149:
2138:
2128:
2117:
2107:
2096:
2064:
2049:
2039:
2028:
2007:
1986:
1965:
1944:
1923:
1902:
1881:
1860:
1842:
1821:
1788:
1763:
1742:
1713:
1695:
1666:
1645:
1311:
1280:
1268:
1236:
1214:
1111:
1091:
1083:
1053:
1049:
1045:
1041:
1037:
1033:
994:
962:
915:
882:
937:
so they can screen for invasion of pathogens by interacting with
5848:
5843:
5832:
5330:
5315:
5304:
5278:
5257:
5187:
5182:
5177:
5172:
5161:
5130:
5125:
5114:
5069:
5064:
5023:
5018:
5007:
4977:
4972:
4967:
4962:
4951:
4663:
4610:
4178:
4119:
4114:
3894:
3889:
3884:
3879:
3873:
3867:
3861:
3855:
3850:
2786:
2614:
2595:
2511:
2500:
2490:
2479:
1997:
1955:
1934:
1913:
1892:
1871:
1832:
1811:
1807:
1803:
1799:
1774:
1753:
1732:
1724:
1685:
1677:
1656:
1641:
1631:
1627:
1623:
1612:
1602:
1591:
1581:
1570:
1560:
1549:
1539:
1535:
1524:
1514:
1503:
1493:
1482:
1473:
1462:
1343:
1284:
1264:
1210:
1180:
1107:
1103:
1099:
1095:
974:
132:
67:
4904:
3789:
2906:
2902:
1339:
1133:
The main function of chemokines is to manage the migration of
683:
1372:
shape that is a characteristic of chemokines. Intramolecular
1141:) in the respective anatomical locations in inflammatory and
957:
and are released from a wide variety of cells in response to
3657:"Peptide and protein-based inhibitors of HIV-1 co-receptors"
1408:. These helices and strands are connected by turns called
929:
during processes of immune surveillance, such as directing
2825:
Chemokine receptors associate with G-proteins to transmit
33:
Small cytokines (intecrine/chemokine), interleukin-8 like
1191:. As well CXCL12 (SDF-1) constitutively produced in the
1360:
that are important for creating their 3-dimensional or
27:
Small cytokines or signaling proteins secreted by cells
2997:
Charo, Israel F.; Ransohoff, Richard M. (2006-02-09).
1392:. This is followed by a single-turn helix, called a
1205:
chemokines are produced in high concentrations during
823:
well as in the pathogenesis of diseases like cancers.
1175:. CCR9 supports the migration of leukocytes into the
1021:
Chemokines are functionally divided into two groups:
5933:
5912:
5905:
5880:
5871:
5831:
5822:
5757:
5736:
5715:
5658:
5606:
5506:
5446:
5437:
5407:
5376:
5350:
5329:
5303:
5277:
5256:
5160:
5113:
5052:
5006:
4950:
4941:
4795:
4753:
4722:
4650:
4624:
4531:
4522:
4463:
4454:
4419:
4382:
4320:
4292:
4246:
4231:
4222:
4132:
4107:
4091:
3994:
3843:
3834:
3827:
2885:within the cell harbouring the chemokine receptor.
2659:The two N-terminal cysteines of CXC chemokines (or
1368:that interact with each other in pairs to create a
1151:: homeostatic chemokines are basal produced in the
714:. Unsourced material may be challenged and removed.
181:
169:
149:
131:
126:
102:
90:
78:
66:
58:
53:
32:
2804:loops, and an intracellular C-terminus containing
2628:) attracts cells such as T cells, eosinophils and
2785:that binds the sole CX3C chemokine (CX3CL1), and
2683:. An example of an ELR-positive CXC chemokine is
3447:Laing KJ, Secombes CJ (May 2004). "Chemokines".
3247:Le Y, Zhou Y, Iribarren P, Wang J (April 2004).
941:residing in these tissues. These are known as
3377:The Journal of Allergy and Clinical Immunology
3279:
3277:
3150:
3148:
965:and agents that cause physical damage such as
4916:
3801:
8:
3585:: CS1 maint: DOI inactive as of July 2024 (
3414:Annual Review of Pharmacology and Toxicology
2643:levels in blood plasma are associated with
5909:
5877:
5828:
5443:
4947:
4923:
4909:
4901:
4528:
4460:
4243:
4228:
3840:
3831:
3808:
3794:
3786:
3561:10.1182/blood.V95.10.3032.010k17_3032_3043
2728:C chemokine (or d-chemokines). The only CX
1356:homology. They all also possess conserved
1287:(RANTES) acts through a specific receptor
123:
38:
3774:The cytokine family database – Chemokines
3747:
3729:
3680:
3516:
3426:10.1146/annurev.pharmtox.42.091901.115838
3388:
3223:
3069:
2973:
2732:C chemokine discovered to date is called
774:Learn how and when to remove this message
3449:Developmental and Comparative Immunology
2679:, and interact with chemokine receptors
2578:) proteins have two adjacent cysteines (
1427:
3538:
3536:
2929:
2857:(PKC), and IP3 triggers the release of
2839:phosphatidylinositol (4,5)-bisphosphate
3655:von Recum HA, Pokorski JK (May 2013).
3578:
857:. Some chemokines are considered pro-
29:
3200:"The chemokine superfamily revisited"
2877:anions and changes in the avidity of
2837:(PLC). PLC cleaves a molecule called
7:
2935:
2933:
2893:The discovery that the β chemokines
1183:and CXCR5 supports the migration of
889:, but none have been found in other
712:adding citations to reliable sources
3256:Cellular & Molecular Immunology
2036:CTACK, ILC, Eskine, PESKY, skinkine
3780:The correct chemokine nomenclature
2942:"Chemokines in health and disease"
2615:monocyte chemoattractant protein-1
2591:
1910:SLC, 6Ckine, Exodus-2, Ckβ9, TCA-4
1771:Leukotactin-1, MIP-5, HCC-2, NCC-3
1271:might be inhibitory of mast cells.
993:and other effector cells from the
48:, a chemokine of the CXC subfamily
25:
3661:Experimental Biology and Medicine
2769:that are found on the surface of
2613:Examples of CC chemokine include
2594:)-1 to -28; CCL10 is the same as
1850:PARC, DC-CK1, AMAC-1, Ckβ7, MIP-4
3198:Zlotnik A, Yoshie O (May 2012).
3062:10.1111/j.1423-0410.2008.01127.x
2899:macrophage inflammatory proteins
2551:Fractalkine, Neurotactin, ABCD-3
1431:
1322:structure that is stabilised by
688:
5223:Cenicriviroc (TAK-652, TBR-652)
5044:Cenicriviroc (TAK-652, TBR-652)
3003:New England Journal of Medicine
2865:) that generate responses like
1364:, such as (in most cases) four
1316:All chemokines share a typical
877:. Chemokines are found in all
699:needs additional citations for
3543:Murdoch C, Finn A (May 2000).
3123:10.1016/j.jneuroim.2008.04.022
2015:Eotaxin-3, MIP-4a, IMAC, TSC-1
1267:. There is also evidence that
869:, while others are considered
1:
3626:10.1126/science.270.5243.1811
2602:and other cell types such as
1750:HCC-1, MCIF, Ckβ1, NCC-2, CCL
851:Platelet factor-4 superfamily
127:Available protein structures:
5563:Interleukin-8 (CXCL8, GCP-1)
5473:Interleukin-8 (CXCL8, GCP-1)
3330:Journal of Leukocyte Biology
3216:10.1016/j.immuni.2012.05.008
2487:Lymphotactin a, SCM-1a, ATAC
800: 'alchemy' and
2958:10.1016/j.yexcr.2011.01.005
2763:G protein-coupled receptors
1952:MPIF-1, Ckβ8, MIP-3, MPIF-1
5997:
3157:Nature Reviews. Immunology
3111:Journal of Neuroimmunology
2946:Experimental Cell Research
2777:that bind CXC chemokines,
2751:
2632:that express the receptor
1308:Structural characteristics
1126:
1032:migration. These include:
4771:Colony-stimulating factor
3461:10.1016/j.dci.2003.09.006
3383:(6): 1185–99, quiz 1200.
3044:Davenport, R. D. (2009).
2781:that bind CC chemokines,
2520:
2456:
2252:IL-8, NAP-1, MDNCF, GCP-1
2234:NAP-2, CTAPIII, β-Ta, PEP
2073:
1439:
1430:
122:
37:
4806:proinflammatory cytokine
3731:10.1073/pnas.96.21.11986
3673:10.1177/1535370213480696
3286:The Journal of Pathology
1829:TARC, dendrokine, ABCD-2
1165:antigen-presenting cells
939:antigen-presenting cells
3563:(inactive 2024-07-29).
2879:cell adhesion molecules
2693:CXC chemokine receptors
1973:Eotaxin-2, MPIF-2, Ckβ6
1221:Types by cell attracted
902:transmembrane receptors
847:SCY family of cytokines
843:SIG family of cytokines
839:SIS family of cytokines
5598:Reparixin (repertaxin)
5498:Reparixin (repertaxin)
3937:/PARC/DCCK1/AMAC1/MIP4
2651:) in mice and humans.
2508:Lymphotactin β, SCM-1β
2104:Gro-a, GRO1, NAP-3, KC
1796:LEC, NCC-4, LMC, Ckβ12
1331:
1129:Homing (hematopoietic)
1011:adaptive immune system
921:
830:in mass and have four
44:Solution structure of
5849:Lymphotactin-β (XCL2)
5844:Lymphotactin-α (XCL1)
3390:10.1067/mai.2003.1594
2847:Inositol triphosphate
2767:transmembrane domains
2752:Further information:
2574:The CC chemokine (or
1315:
1127:Further information:
919:
5893:Fractalkine (CX3CL1)
5810:Plerixafor (AMD3100)
5696:Plerixafor (AMD3100)
3015:10.1056/NEJMra052723
2919:Paracrine signalling
1889:LARC, Exodus-1, Ckβ4
1868:ELC, Exodus-3, Ckβ11
1653:MRP-2, CCF18, MIP-1?
1338:of between 8 and 10
1163:is possible routing
1007:innate immune system
708:improve this article
5981:Signal transduction
4502:Interferon type III
3776:at kumamoto-u.ac.jp
3722:1999PNAS...9611986G
3716:(21): 11986–11991.
3618:1995Sci...270.1811C
3612:(5243): 1811–1815.
3509:10.1038/nature10357
3501:2011Natur.477...90V
3342:10.1189/jlb.1102573
2845:molecules known as
2821:Signal transduction
2759:Chemokine receptors
2146:Gro-?, GRO3, MIP-2β
2125:Gro-β, GRO2, MIP-2a
1721:MCP-4, NCC-1, Ckβ10
1213:, CXCL1, CXCL2 and
949:(the growth of new
906:chemokine receptors
4932:Chemokine receptor
2863:MAP kinase pathway
2754:Chemokine receptor
1424:Types by structure
1362:tertiary structure
1332:
1326:between conserved
922:
5963:
5962:
5959:
5958:
5925:CC (β) chemokines
5901:
5900:
5867:
5866:
5818:
5817:
5512:
5452:
5433:
5432:
4898:
4897:
4791:
4790:
4749:
4748:
4646:
4645:
4642:
4641:
4450:
4449:
4128:
4127:
3782:at rndsystems.com
3298:10.1002/path.4123
2889:Infection control
2742:adhesion molecule
2563:
2562:
2319:I-TAC, β-R1, IP-9
1404:and a C-terminal
1249:T-cell activation
1017:Types by function
784:
783:
776:
758:
682:
681:
678:
677:
176:structure summary
16:(Redirected from
5988:
5910:
5878:
5829:
5651:(against CXCL10)
5510:
5450:
5444:
4948:
4925:
4918:
4911:
4902:
4529:
4461:
4244:
4229:
3841:
3832:
3810:
3803:
3796:
3787:
3762:
3761:
3751:
3733:
3701:
3695:
3694:
3684:
3652:
3646:
3645:
3597:
3591:
3590:
3584:
3576:
3571:. Archived from
3540:
3531:
3530:
3520:
3479:
3473:
3472:
3444:
3438:
3437:
3409:
3403:
3402:
3392:
3368:
3362:
3361:
3324:
3318:
3317:
3281:
3272:
3271:
3253:
3244:
3238:
3237:
3227:
3195:
3189:
3188:
3152:
3143:
3142:
3106:
3100:
3099:
3073:
3041:
3035:
3034:
2994:
2988:
2987:
2977:
2937:
2855:protein kinase C
2843:second messenger
2841:(PIP2) into two
2521:CX3C chemokines
1435:
1428:
1187:to follicles of
1090:. Examples are:
779:
772:
768:
765:
759:
757:
716:
692:
684:
673:
667:
661:
654:
648:
642:
636:
630:
624:
618:
612:
606:
600:
594:
588:
582:
576:
570:
564:
558:
552:
546:
540:
534:
528:
522:
516:
510:
504:
498:
492:
486:
480:
474:
468:
462:
456:
450:
444:
438:
432:
426:
420:
414:
408:
402:
396:
390:
384:
378:
372:
366:
360:
354:
348:
342:
336:
330:
324:
318:
312:
306:
300:
294:
288:
282:
276:
270:
264:
258:
252:
246:
240:
234:
228:
222:
216:
210:
203:
197:
191:
124:
42:
30:
21:
5996:
5995:
5991:
5990:
5989:
5987:
5986:
5985:
5966:
5965:
5964:
5955:
5929:
5897:
5863:
5814:
5753:
5732:
5711:
5708:(against CXCR4)
5654:
5602:
5509:
5502:
5449:
5429:
5420:(against CCL11)
5403:
5372:
5346:
5325:
5299:
5273:
5252:
5156:
5109:
5048:
5002:
4937:
4929:
4899:
4894:
4860:
4839:
4797:
4787:
4745:
4718:
4638:
4620:
4518:
4446:
4415:
4378:
4316:
4288:
4239:
4237:
4235:
4218:
4124:
4103:
4087:
3990:
3823:
3814:
3770:
3765:
3703:
3702:
3698:
3654:
3653:
3649:
3599:
3598:
3594:
3577:
3555:(10): 3032–43.
3542:
3541:
3534:
3481:
3480:
3476:
3446:
3445:
3441:
3411:
3410:
3406:
3370:
3369:
3365:
3326:
3325:
3321:
3283:
3282:
3275:
3251:
3246:
3245:
3241:
3197:
3196:
3192:
3169:10.1038/nri3049
3154:
3153:
3146:
3108:
3107:
3103:
3043:
3042:
3038:
2996:
2995:
2991:
2939:
2938:
2931:
2927:
2915:
2891:
2835:phospholipase C
2823:
2756:
2750:
2739:
2731:
2727:
2722:
2719:
2701:
2681:CXCR1 and CXCR2
2657:
2608:dendritic cells
2572:
2408:Lungkine, WECHE
2074:CXC chemokines
1426:
1397:
1374:disulfide bonds
1324:disulfide bonds
1310:
1223:
1179:, CCR10 to the
1131:
1125:
1019:
914:
780:
769:
763:
760:
717:
715:
705:
693:
669:
663:
657:
650:
644:
638:
632:
626:
620:
614:
608:
602:
596:
590:
584:
578:
572:
566:
560:
554:
548:
542:
536:
530:
524:
518:
512:
506:
500:
494:
488:
482:
476:
470:
464:
458:
452:
446:
440:
434:
428:
422:
416:
410:
404:
398:
392:
386:
380:
374:
368:
362:
356:
350:
344:
338:
332:
326:
320:
314:
308:
302:
296:
290:
284:
278:
272:
266:
260:
254:
248:
242:
236:
230:
224:
218:
212:
206:
199:
193:
187:
49:
28:
23:
22:
15:
12:
11:
5:
5994:
5992:
5984:
5983:
5978:
5968:
5967:
5961:
5960:
5957:
5956:
5954:
5953:
5948:
5939:
5937:
5931:
5930:
5928:
5927:
5918:
5916:
5907:
5903:
5902:
5899:
5898:
5896:
5895:
5886:
5884:
5875:
5869:
5868:
5865:
5864:
5862:
5861:
5852:
5851:
5846:
5837:
5835:
5826:
5820:
5819:
5816:
5815:
5813:
5812:
5803:
5802:
5797:
5795:SDF-1 (CXCL12)
5792:
5787:
5782:
5777:
5775:CXCL11 (I-TAC)
5772:
5763:
5761:
5755:
5754:
5752:
5751:
5742:
5740:
5734:
5733:
5731:
5730:
5721:
5719:
5713:
5712:
5710:
5709:
5699:
5698:
5693:
5684:
5683:
5678:
5676:SDF-1 (CXCL12)
5673:
5664:
5662:
5656:
5655:
5653:
5652:
5642:
5641:
5636:
5634:CXCL11 (I-TAC)
5631:
5629:CXCL10 (IP-10)
5626:
5621:
5612:
5610:
5604:
5603:
5601:
5600:
5595:
5586:
5585:
5580:
5575:
5566:
5565:
5560:
5555:
5550:
5545:
5540:
5535:
5530:
5525:
5516:
5514:
5504:
5503:
5501:
5500:
5495:
5486:
5485:
5476:
5475:
5470:
5465:
5456:
5454:
5441:
5435:
5434:
5431:
5430:
5428:
5427:
5426:(against CCL2)
5421:
5411:
5409:
5405:
5404:
5402:
5401:
5396:
5391:
5382:
5380:
5374:
5373:
5371:
5370:
5365:
5356:
5354:
5348:
5347:
5345:
5344:
5335:
5333:
5327:
5326:
5324:
5323:
5318:
5309:
5307:
5301:
5300:
5298:
5297:
5292:
5283:
5281:
5275:
5274:
5272:
5271:
5262:
5260:
5254:
5253:
5251:
5250:
5241:
5240:
5235:
5230:
5225:
5220:
5211:
5210:
5205:
5200:
5195:
5190:
5185:
5180:
5175:
5166:
5164:
5158:
5157:
5155:
5154:
5153:(against CCR4)
5144:
5143:
5138:
5133:
5128:
5119:
5117:
5111:
5110:
5108:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5058:
5056:
5050:
5049:
5047:
5046:
5037:
5036:
5031:
5026:
5021:
5012:
5010:
5004:
5003:
5001:
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4956:
4954:
4945:
4939:
4938:
4930:
4928:
4927:
4920:
4913:
4905:
4896:
4895:
4893:
4892:
4891:
4890:
4889:
4888:
4883:
4878:
4873:
4868:
4858:
4854:
4853:
4852:
4847:
4837:
4828:
4822:
4821:
4820:
4819:
4814:
4801:
4799:
4793:
4792:
4789:
4788:
4786:
4785:
4780:
4775:
4774:
4773:
4768:
4757:
4755:
4751:
4750:
4747:
4746:
4744:
4743:
4728:
4726:
4720:
4719:
4717:
4716:
4711:
4706:
4701:
4696:
4691:
4686:
4681:
4676:
4671:
4666:
4656:
4654:
4652:Ig superfamily
4648:
4647:
4644:
4643:
4640:
4639:
4637:
4636:
4630:
4628:
4622:
4621:
4619:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4537:
4535:
4526:
4520:
4519:
4517:
4516:
4515:
4514:
4509:
4499:
4494:
4489:
4484:
4479:
4469:
4467:
4458:
4452:
4451:
4448:
4447:
4445:
4444:
4439:
4434:
4429:
4423:
4421:
4417:
4416:
4414:
4413:
4408:
4403:
4398:
4392:
4390:
4380:
4379:
4377:
4376:
4375:
4374:
4369:
4364:
4359:
4348:
4343:
4338:
4333:
4327:
4325:
4318:
4317:
4315:
4314:
4309:
4304:
4298:
4296:
4290:
4289:
4287:
4286:
4281:
4276:
4271:
4262:
4252:
4250:
4241:
4226:
4220:
4219:
4217:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4160:
4159:
4154:
4144:
4138:
4136:
4130:
4129:
4126:
4125:
4123:
4122:
4117:
4111:
4109:
4105:
4104:
4102:
4101:
4095:
4093:
4089:
4088:
4086:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
4015:
4010:
4005:
3998:
3996:
3992:
3991:
3989:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3871:
3865:
3859:
3853:
3847:
3845:
3838:
3829:
3825:
3824:
3817:Cell signaling
3815:
3813:
3812:
3805:
3798:
3790:
3784:
3783:
3777:
3769:
3768:External links
3766:
3764:
3763:
3696:
3667:(5): 442–449.
3647:
3592:
3575:on 2013-07-04.
3532:
3495:(7362): 90–4.
3474:
3439:
3404:
3363:
3319:
3273:
3239:
3190:
3163:(9): 597–606.
3144:
3101:
3056:(3): 183–198.
3036:
3009:(6): 610–621.
2989:
2952:(5): 575–589.
2928:
2926:
2923:
2922:
2921:
2914:
2911:
2890:
2887:
2851:diacylglycerol
2822:
2819:
2749:
2746:
2737:
2729:
2725:
2721:
2717:
2714:
2708:-α) and XCL2 (
2700:
2697:
2656:
2655:CXC chemokines
2653:
2584:amino terminus
2582:), near their
2571:
2568:
2561:
2560:
2557:
2552:
2549:
2546:
2540:
2539:
2536:
2533:
2530:
2527:
2523:
2522:
2518:
2517:
2514:
2509:
2506:
2503:
2497:
2496:
2493:
2488:
2485:
2482:
2476:
2475:
2472:
2469:
2466:
2463:
2459:
2458:
2454:
2453:
2450:
2448:
2445:
2442:
2436:
2435:
2432:
2427:
2424:
2421:
2415:
2414:
2411:
2409:
2406:
2403:
2397:
2396:
2393:
2391:
2390:BRAK, bolekine
2388:
2385:
2379:
2378:
2375:
2370:
2367:
2364:
2358:
2357:
2354:
2345:
2342:
2339:
2333:
2332:
2329:
2320:
2317:
2314:
2308:
2307:
2304:
2299:
2296:
2293:
2287:
2286:
2283:
2278:
2275:
2272:
2266:
2265:
2262:
2253:
2250:
2247:
2241:
2240:
2237:
2235:
2232:
2229:
2223:
2222:
2219:
2210:
2207:
2204:
2198:
2197:
2194:
2189:
2186:
2183:
2177:
2176:
2173:
2168:
2165:
2162:
2156:
2155:
2152:
2147:
2144:
2141:
2135:
2134:
2131:
2126:
2123:
2120:
2114:
2113:
2110:
2105:
2102:
2099:
2093:
2092:
2089:
2086:
2083:
2080:
2076:
2075:
2071:
2070:
2067:
2058:
2055:
2052:
2046:
2045:
2042:
2037:
2034:
2031:
2025:
2024:
2021:
2016:
2013:
2010:
2004:
2003:
2000:
1995:
1992:
1989:
1983:
1982:
1979:
1974:
1971:
1968:
1962:
1961:
1958:
1953:
1950:
1947:
1941:
1940:
1937:
1932:
1929:
1926:
1920:
1919:
1916:
1911:
1908:
1905:
1899:
1898:
1895:
1890:
1887:
1884:
1878:
1877:
1874:
1869:
1866:
1863:
1857:
1856:
1853:
1851:
1848:
1845:
1839:
1838:
1835:
1830:
1827:
1824:
1818:
1817:
1814:
1797:
1794:
1791:
1785:
1784:
1781:
1772:
1769:
1766:
1760:
1759:
1756:
1751:
1748:
1745:
1739:
1738:
1735:
1722:
1719:
1716:
1710:
1709:
1706:
1704:
1701:
1698:
1692:
1691:
1688:
1675:
1672:
1669:
1663:
1662:
1659:
1654:
1651:
1648:
1638:
1637:
1634:
1621:
1618:
1615:
1609:
1608:
1605:
1600:
1597:
1594:
1588:
1587:
1584:
1579:
1576:
1573:
1567:
1566:
1563:
1558:
1555:
1552:
1546:
1545:
1542:
1533:
1530:
1527:
1521:
1520:
1517:
1512:
1509:
1506:
1500:
1499:
1496:
1491:
1488:
1485:
1479:
1478:
1476:
1471:
1468:
1465:
1459:
1458:
1455:
1452:
1449:
1446:
1442:
1441:
1440:CC chemokines
1437:
1436:
1425:
1422:
1395:
1386:C-terminal end
1382:N-terminal end
1336:molecular mass
1309:
1306:
1305:
1304:
1292:
1283:(eotaxin) and
1272:
1252:
1240:
1222:
1219:
1124:
1121:
1120:
1119:
1065:
1018:
1015:
973:that occur in
971:urate crystals
913:
910:
782:
781:
696:
694:
687:
680:
679:
676:
675:
185:
179:
178:
173:
167:
166:
153:
147:
146:
136:
129:
128:
120:
119:
106:
100:
99:
94:
88:
87:
82:
76:
75:
70:
64:
63:
60:
56:
55:
51:
50:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5993:
5982:
5979:
5977:
5974:
5973:
5971:
5952:
5949:
5947:
5944:
5941:
5940:
5938:
5936:
5932:
5926:
5923:
5920:
5919:
5917:
5915:
5911:
5908:
5904:
5894:
5891:
5888:
5887:
5885:
5883:
5879:
5876:
5874:
5870:
5860:
5857:
5854:
5853:
5850:
5847:
5845:
5842:
5839:
5838:
5836:
5834:
5830:
5827:
5825:
5821:
5811:
5808:
5805:
5804:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5778:
5776:
5773:
5771:
5768:
5765:
5764:
5762:
5760:
5756:
5750:
5747:
5744:
5743:
5741:
5739:
5735:
5729:
5726:
5723:
5722:
5720:
5718:
5714:
5707:
5704:
5701:
5700:
5697:
5694:
5692:
5689:
5686:
5685:
5682:
5679:
5677:
5674:
5672:
5669:
5666:
5665:
5663:
5661:
5657:
5650:
5647:
5644:
5643:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5614:
5613:
5611:
5609:
5605:
5599:
5596:
5594:
5591:
5588:
5587:
5584:
5581:
5579:
5576:
5574:
5571:
5568:
5567:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5518:
5517:
5515:
5513:
5505:
5499:
5496:
5494:
5491:
5488:
5487:
5484:
5481:
5478:
5477:
5474:
5471:
5469:
5466:
5464:
5461:
5458:
5457:
5455:
5453:
5445:
5442:
5440:
5436:
5425:
5422:
5419:
5416:
5413:
5412:
5410:
5406:
5400:
5397:
5395:
5392:
5390:
5387:
5384:
5383:
5381:
5379:
5375:
5369:
5366:
5364:
5361:
5358:
5357:
5355:
5353:
5349:
5343:
5340:
5337:
5336:
5334:
5332:
5328:
5322:
5319:
5317:
5314:
5311:
5310:
5308:
5306:
5302:
5296:
5293:
5291:
5288:
5285:
5284:
5282:
5280:
5276:
5270:
5267:
5264:
5263:
5261:
5259:
5255:
5249:
5246:
5243:
5242:
5239:
5236:
5234:
5231:
5229:
5226:
5224:
5221:
5219:
5216:
5213:
5212:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5183:CCL5 (RANTES)
5181:
5179:
5178:CCL4 (MIP-1β)
5176:
5174:
5173:CCL3 (MIP-1α)
5171:
5168:
5167:
5165:
5163:
5159:
5152:
5151:Mogamulizumab
5149:
5146:
5145:
5142:
5139:
5137:
5134:
5132:
5131:CCL5 (RANTES)
5129:
5127:
5126:CCL3 (MIP-1α)
5124:
5121:
5120:
5118:
5116:
5112:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5065:CCL5 (RANTES)
5063:
5060:
5059:
5057:
5055:
5051:
5045:
5042:
5039:
5038:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5014:
5013:
5011:
5009:
5005:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4968:CCL5 (RANTES)
4966:
4964:
4963:CCL4 (MIP-1β)
4961:
4958:
4957:
4955:
4953:
4949:
4946:
4944:
4940:
4936:
4933:
4926:
4921:
4919:
4914:
4912:
4907:
4906:
4903:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4863:
4862:
4855:
4851:
4848:
4846:
4843:
4842:
4841:
4834:
4833:
4832:
4829:
4827:
4824:
4823:
4818:
4815:
4813:
4810:
4809:
4808:
4807:
4803:
4802:
4800:
4794:
4784:
4781:
4779:
4776:
4772:
4769:
4767:
4764:
4763:
4762:
4761:Hematopoietic
4759:
4758:
4756:
4752:
4741:
4737:
4733:
4730:
4729:
4727:
4725:
4721:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4661:
4658:
4657:
4655:
4653:
4649:
4635:
4632:
4631:
4629:
4627:
4623:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4538:
4536:
4534:
4530:
4527:
4525:
4521:
4513:
4510:
4508:
4505:
4504:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4474:
4471:
4470:
4468:
4466:
4462:
4459:
4457:
4453:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4424:
4422:
4418:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4393:
4391:
4389:
4385:
4381:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4354:
4353:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4328:
4326:
4324:
4319:
4313:
4310:
4308:
4305:
4303:
4300:
4299:
4297:
4295:
4291:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4266:
4263:
4261:
4257:
4254:
4253:
4251:
4249:
4245:
4242:
4234:
4230:
4227:
4225:
4221:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4169:TNFSF5/CD40LG
4167:
4165:
4162:
4158:
4155:
4153:
4150:
4149:
4148:
4145:
4143:
4140:
4139:
4137:
4135:
4131:
4121:
4118:
4116:
4113:
4112:
4110:
4106:
4100:
4097:
4096:
4094:
4090:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4003:
4000:
3999:
3997:
3993:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3875:
3872:
3869:
3866:
3863:
3860:
3857:
3854:
3852:
3849:
3848:
3846:
3842:
3839:
3837:
3833:
3830:
3826:
3822:
3818:
3811:
3806:
3804:
3799:
3797:
3792:
3791:
3788:
3781:
3778:
3775:
3772:
3771:
3767:
3759:
3755:
3750:
3745:
3741:
3737:
3732:
3727:
3723:
3719:
3715:
3711:
3707:
3700:
3697:
3692:
3688:
3683:
3678:
3674:
3670:
3666:
3662:
3658:
3651:
3648:
3643:
3639:
3635:
3631:
3627:
3623:
3619:
3615:
3611:
3607:
3603:
3596:
3593:
3588:
3582:
3574:
3570:
3566:
3562:
3558:
3554:
3550:
3546:
3539:
3537:
3533:
3528:
3524:
3519:
3514:
3510:
3506:
3502:
3498:
3494:
3490:
3486:
3478:
3475:
3470:
3466:
3462:
3458:
3455:(5): 443–60.
3454:
3450:
3443:
3440:
3435:
3431:
3427:
3423:
3419:
3415:
3408:
3405:
3400:
3396:
3391:
3386:
3382:
3378:
3374:
3367:
3364:
3359:
3355:
3351:
3347:
3343:
3339:
3336:(6): 771–80.
3335:
3331:
3323:
3320:
3315:
3311:
3307:
3303:
3299:
3295:
3292:(2): 168–75.
3291:
3287:
3280:
3278:
3274:
3269:
3265:
3262:(2): 95–104.
3261:
3257:
3250:
3243:
3240:
3235:
3231:
3226:
3221:
3217:
3213:
3210:(5): 705–16.
3209:
3205:
3201:
3194:
3191:
3186:
3182:
3178:
3174:
3170:
3166:
3162:
3158:
3151:
3149:
3145:
3140:
3136:
3132:
3128:
3124:
3120:
3117:(1–2): 62–8.
3116:
3112:
3105:
3102:
3097:
3093:
3089:
3085:
3081:
3077:
3072:
3071:2027.42/74808
3067:
3063:
3059:
3055:
3051:
3050:Vox Sanguinis
3047:
3040:
3037:
3032:
3028:
3024:
3020:
3016:
3012:
3008:
3004:
3000:
2993:
2990:
2985:
2981:
2976:
2971:
2967:
2963:
2959:
2955:
2951:
2947:
2943:
2936:
2934:
2930:
2924:
2920:
2917:
2916:
2912:
2910:
2908:
2904:
2900:
2896:
2888:
2886:
2884:
2880:
2876:
2873:, release of
2872:
2871:degranulation
2868:
2864:
2860:
2856:
2852:
2848:
2844:
2840:
2836:
2832:
2828:
2820:
2818:
2815:
2811:
2807:
2803:
2800:
2799:extracellular
2796:
2795:intracellular
2792:
2788:
2784:
2780:
2776:
2772:
2768:
2765:containing 7
2764:
2760:
2755:
2747:
2745:
2743:
2735:
2715:
2713:
2711:
2707:
2698:
2696:
2694:
2690:
2686:
2685:interleukin-8
2682:
2678:
2674:
2670:
2666:
2665:glutamic acid
2662:
2654:
2652:
2650:
2647:(and reduced
2646:
2642:
2637:
2635:
2631:
2627:
2622:
2620:
2616:
2611:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2577:
2570:CC chemokines
2569:
2567:
2558:
2556:
2553:
2550:
2547:
2545:
2542:
2541:
2537:
2534:
2532:Other name(s)
2531:
2528:
2525:
2524:
2519:
2515:
2513:
2510:
2507:
2504:
2502:
2499:
2498:
2494:
2492:
2489:
2486:
2483:
2481:
2478:
2477:
2473:
2470:
2468:Other name(s)
2467:
2464:
2461:
2460:
2457:C chemokines
2455:
2451:
2449:
2446:
2443:
2441:
2438:
2437:
2433:
2431:
2428:
2425:
2422:
2420:
2417:
2416:
2412:
2410:
2407:
2404:
2402:
2399:
2398:
2394:
2392:
2389:
2386:
2384:
2381:
2380:
2376:
2374:
2371:
2368:
2365:
2363:
2360:
2359:
2355:
2353:
2349:
2346:
2343:
2340:
2338:
2335:
2334:
2330:
2328:
2324:
2321:
2318:
2315:
2313:
2310:
2309:
2305:
2303:
2300:
2297:
2294:
2292:
2289:
2288:
2284:
2282:
2279:
2276:
2273:
2271:
2268:
2267:
2263:
2261:
2257:
2254:
2251:
2248:
2246:
2243:
2242:
2238:
2236:
2233:
2230:
2228:
2225:
2224:
2220:
2218:
2214:
2211:
2208:
2205:
2203:
2200:
2199:
2195:
2193:
2190:
2187:
2184:
2182:
2179:
2178:
2174:
2172:
2169:
2166:
2163:
2161:
2158:
2157:
2153:
2151:
2148:
2145:
2142:
2140:
2137:
2136:
2132:
2130:
2127:
2124:
2121:
2119:
2116:
2115:
2111:
2109:
2106:
2103:
2100:
2098:
2095:
2094:
2090:
2087:
2085:Other name(s)
2084:
2081:
2078:
2077:
2072:
2068:
2066:
2062:
2059:
2056:
2053:
2051:
2048:
2047:
2043:
2041:
2038:
2035:
2032:
2030:
2027:
2026:
2022:
2020:
2017:
2014:
2011:
2009:
2006:
2005:
2001:
1999:
1996:
1993:
1990:
1988:
1985:
1984:
1980:
1978:
1975:
1972:
1969:
1967:
1964:
1963:
1959:
1957:
1954:
1951:
1948:
1946:
1943:
1942:
1938:
1936:
1933:
1930:
1927:
1925:
1922:
1921:
1917:
1915:
1912:
1909:
1906:
1904:
1901:
1900:
1896:
1894:
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1480:
1477:
1475:
1472:
1469:
1466:
1464:
1461:
1460:
1456:
1453:
1451:Other name(s)
1450:
1447:
1444:
1443:
1438:
1434:
1429:
1423:
1421:
1419:
1415:
1411:
1407:
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1348:
1345:
1341:
1337:
1329:
1325:
1321:
1320:
1314:
1307:
1302:
1301:degranulation
1298:
1297:
1293:
1290:
1286:
1282:
1278:
1277:
1273:
1270:
1266:
1262:
1258:
1257:
1253:
1250:
1246:
1245:
1244:T-lymphocytes
1241:
1238:
1234:
1233:
1229:
1225:
1224:
1220:
1218:
1216:
1212:
1208:
1204:
1200:
1196:
1194:
1190:
1186:
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1178:
1174:
1170:
1166:
1162:
1158:
1154:
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1109:
1105:
1101:
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1093:
1089:
1085:
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1077:
1073:
1069:
1066:
1063:
1059:
1055:
1051:
1047:
1043:
1039:
1035:
1031:
1027:
1024:
1023:
1022:
1016:
1014:
1012:
1008:
1004:
1003:wound healing
1000:
996:
992:
988:
985:, recruiting
984:
980:
979:interleukin 1
976:
972:
968:
964:
960:
956:
952:
951:blood vessels
948:
944:
940:
936:
932:
928:
927:immune system
918:
911:
909:
907:
903:
899:
894:
892:
891:invertebrates
888:
884:
880:
876:
872:
868:
865:to a site of
864:
863:immune system
860:
856:
852:
848:
844:
840:
835:
833:
829:
824:
821:
817:
814:
810:
806:
802:
799:
795:
792:
791:Ancient Greek
788:
778:
775:
767:
756:
753:
749:
746:
742:
739:
735:
732:
728:
725: –
724:
720:
719:Find sources:
713:
709:
703:
702:
697:This article
695:
691:
686:
685:
672:
666:
660:
656:
655:B:22-87
653:
647:
641:
637:A:22-89
635:
629:
623:
619:A:22-89
617:
611:
605:
601:D:32-98
599:
593:
587:
583:C:39-98
581:
575:
569:
565:A:28-94
563:
557:
551:
547:B:35-101
545:
539:
533:
529:C:61-121
527:
521:
515:
511:B:34-93
509:
503:
497:
491:
485:
479:
475:A:29-93
473:
467:
461:
457:A:26-89
455:
449:
443:
439:A:24-88
437:
431:
425:
421:A:23-84
419:
413:
407:
403:A:26-33
401:
395:
389:
385:A:26-89
383:
377:
371:
367:A:26-91
365:
359:
353:
349:A:24-88
347:
341:
335:
331:B:25-88
329:
323:
317:
313:D:24-88
311:
305:
299:
295:B:24-88
293:
287:
281:
277:A:24-89
275:
269:
263:
259:A:27-89
257:
251:
245:
241:A:24-90
239:
233:
227:
223:B:24-90
221:
215:
209:
204:A:24-90
202:
196:
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186:
184:
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118:
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98:
95:
93:
89:
86:
83:
81:
77:
74:
71:
69:
65:
61:
57:
52:
47:
46:interleukin-8
41:
36:
31:
19:
5942:
5921:
5889:
5859:Pateclizumab
5855:
5840:
5806:
5766:
5745:
5724:
5702:
5688:Antagonists:
5687:
5667:
5645:
5615:
5589:
5570:Antagonists:
5569:
5523:CXCL1 (MGSA)
5519:
5489:
5480:Antagonists:
5479:
5459:
5418:Bertilimumab
5414:
5385:
5359:
5338:
5312:
5286:
5265:
5244:
5214:
5169:
5147:
5122:
5061:
5040:
5015:
4978:CCL9 (CCL10)
4959:
4856:
4835:
4804:
4796:By function/
4507:IL28/IFNL2+3
3835:
3713:
3709:
3699:
3664:
3660:
3650:
3609:
3605:
3595:
3581:cite journal
3573:the original
3552:
3548:
3492:
3488:
3477:
3452:
3448:
3442:
3417:
3413:
3407:
3380:
3376:
3366:
3333:
3329:
3322:
3289:
3285:
3259:
3255:
3242:
3207:
3203:
3193:
3160:
3156:
3114:
3110:
3104:
3053:
3049:
3039:
3006:
3002:
2992:
2949:
2945:
2892:
2827:cell signals
2824:
2757:
2723:
2720:C chemokines
2710:lymphotactin
2706:lymphotactin
2702:
2699:C chemokines
2661:α-chemokines
2660:
2658:
2649:neurogenesis
2638:
2623:
2612:
2575:
2573:
2564:
2298:IP-10, CRG-2
1931:MDC, DC/β-CK
1470:I-309, TCA-3
1417:
1413:
1409:
1389:
1378:pro-peptides
1333:
1317:
1294:
1274:
1254:
1242:
1226:
1203:inflammatory
1199:Inflammatory
1198:
1197:
1148:
1147:
1132:
1088:inflammation
1068:Inflammatory
1067:
1025:
1020:
997:to sites of
955:inflammatory
947:angiogenesis
923:
895:
859:inflammatory
854:
850:
846:
842:
838:
836:
825:
818:secreted by
804:
801:
797:
794:
786:
785:
770:
761:
751:
744:
737:
730:
718:
706:Please help
701:verification
698:
662:B:29-85
643:A:22-89
631:B:22-89
625:B:22-89
613:D:21-82
607:A:87-98
595:A:39-98
589:D:32-98
577:B:32-98
571:D:38-98
559:A:35-101
553:A:35-101
541:A:54-121
535:D:59-121
523:B:29-93
517:B:28-93
493::31-93
487:A:28-93
481:A:28-93
469:A:28-90
463:A:27-89
451:B:26-89
445:A:24-88
433:A:24-88
427:A:23-84
415:A:24-88
409:A:24-88
397:A:26-89
391:A:26-89
379:B:26-89
373:A:26-89
355:A:45-109
343:A:24-88
337:A:24-88
325:B:24-88
319:B:24-88
307:B:24-88
301:B:26-88
289:B:24-88
283:A:24-89
271:A:24-89
265:A:27-89
235:B:24-90
217:D:24-90
211:B:29-90
205:
192:A:24-90
5951:Resolvin E1
5856:Antibodies:
5790:RTI-5152-12
5706:Ulocuplumab
5703:Antibodies:
5691:Mavorixafor
5646:Antibodies:
5624:CXCL9 (MIG)
5619:CXCL4 (PF4)
5558:Garnocestim
5415:Antibodies:
5245:Antibodies:
5148:Antibodies:
4724:IL17 family
4465:IL10 family
4384:IL12 family
4236:(grouped by
4224:Interleukin
4147:Lymphotoxin
2802:hydrophilic
2791:amino acids
2734:fractalkine
2677:neutrophils
2619:macrophages
2580:amino acids
2576:β-chemokine
2344:SDF-1, PBSF
2277:MIG, CRG-10
1994:TECK, Ckβ15
1599:MARC, MCP-3
1358:amino acids
1296:Neutrophils
1276:Eosinophils
1232:macrophages
1193:bone marrow
1189:lymph nodes
1157:lymph nodes
1145:processes.
1143:homeostatic
1026:Homeostatic
991:neutrophils
961:infection,
943:homeostatic
935:lymph nodes
931:lymphocytes
879:vertebrates
875:development
871:homeostatic
855:intercrines
828:kilodaltons
723:"Chemokine"
668::22-87
649::22-87
505::31-93
499::32-93
361::48-108
253::24-88
247::24-88
229::24-90
198::24-90
54:Identifiers
5970:Categories
5770:Conolidine
5238:Vicriviroc
5228:INCB009471
4935:modulators
4831:Lymphokine
4669:IL1B/IL1F2
4664:IL1A/IL1F1
4660:IL1 family
4524:Interferon
4512:IL29/IFNL1
3420:: 469–99.
2925:References
2875:superoxide
2867:chemotaxis
2849:(IP3) and
2797:and three
2771:leukocytes
2639:Increased
2447:DMC, VCC-1
2369:BCA-1, BLC
1578:C10, MRP-2
1351:amino acid
1256:Mast cells
1173:leukocytes
1135:leukocytes
983:leukocytes
805:(kī́nēsis)
789:(from
787:Chemokines
764:April 2013
734:newspapers
139:structures
18:Chemokines
5976:Cytokines
5943:Agonists:
5922:Agonists:
5890:Agonists:
5841:Agonists:
5767:Agonists:
5746:Agonists:
5725:Agonists:
5681:Ubiquitin
5668:Agonists:
5649:Eldelumab
5616:Agonists:
5593:Ladarixin
5583:Navarixin
5578:Elubrixin
5573:Danirixin
5553:Emoctakin
5520:Agonists:
5493:Ladarixin
5483:Navarixin
5468:Emoctakin
5460:Agonists:
5408:Ungrouped
5386:Agonists:
5360:Agonists:
5339:Agonists:
5313:Agonists:
5287:Agonists:
5266:Agonists:
5233:Maraviroc
5218:Aplaviroc
5170:Agonists:
5123:Agonists:
5062:Agonists:
5016:Agonists:
4960:Agonists:
4709:33/IL1F11
4674:1Ra/IL1F3
4321:IL6 like/
4038:CXCL8/IL8
3836:Chemokine
3828:By family
3821:cytokines
3080:1423-0410
3023:0028-4793
2966:0014-4827
2883:integrins
2833:known as
2810:threonine
2748:Receptors
2630:basophils
2624:CCL5 (or
2600:monocytes
1402:β-strands
1370:Greek key
1366:cysteines
1330:residues.
1319:Greek key
1228:Monocytes
1207:infection
1177:intestine
1169:receptors
1076:TNF-alpha
1030:leukocyte
999:infection
987:monocytes
959:bacterial
898:G protein
885:and some
867:infection
813:signaling
809:cytokines
798:(khumeíā)
97:PDOC00434
85:IPR001811
5946:Chemerin
5800:VUF15485
5639:Iroplact
5511:(IL-8Rβ)
5451:(IL-8Rα)
5424:Carlumab
4826:Monokine
4355:+non IL
4240:subunit)
4238:receptor
4209:TNFSF13B
4157:TNFC/LTB
4152:TNFB/LTA
3758:10518563
3691:23856897
3642:84062618
3569:10807766
3527:21886162
3469:15062643
3434:11807180
3399:12789214
3350:12773510
3314:10825790
3306:23125030
3268:16212895
3234:22633458
3204:Immunity
3185:34438005
3177:21866172
3131:18538863
3096:13880196
3088:19076338
3031:16467548
2984:21223965
2913:See also
2814:cysteine
2673:arginine
2604:NK cells
2538:Uniprot
2535:Receptor
2474:Uniprot
2471:Receptor
2091:Uniprot
2088:Receptor
1457:Uniprot
1454:Receptor
1400:, three
1354:sequence
1347:sequence
1328:cysteine
912:Function
900:-linked
887:bacteria
832:cysteine
816:proteins
803:κῑ́νησῐς
156:RCSB PDB
80:InterPro
5248:PRO-140
4714:18/IL1G
4456:Type II
4388:IL12RB1
4294:β chain
4248:γ chain
4204:TNFSF13
4199:TNFSF11
4194:TNFSF10
3876:/RANTES
3718:Bibcode
3682:3908444
3634:8525373
3614:Bibcode
3606:Science
3518:3170097
3497:Bibcode
3358:8175160
3225:3396424
3139:7141579
2975:3063402
2897:, MIP (
2881:called
2859:calcium
2669:leucine
2588:ligands
2559:P78423
2516:Q9UBD3
2495:P47992
2452:Q6UXB2
2434:Q9H2A7
2413:Q9WVL7
2395:O95715
2377:O43927
2356:P48061
2331:O14625
2306:P02778
2285:Q07325
2264:P10145
2239:P02775
2221:P80162
2196:P42830
2175:P02776
2154:P19876
2133:P19875
2112:P09341
2069:Q9NRJ3
2044:Q9Y4X3
2023:Q9Y258
2002:O15444
1981:O00175
1960:P55773
1939:O00626
1918:O00585
1897:P78556
1876:Q99731
1855:P55774
1837:Q92583
1816:O15467
1783:Q16663
1758:Q16627
1737:Q99616
1708:Q62401
1690:P51671
1674:Eotaxin
1661:P51670
1636:P80075
1607:P80098
1586:P27784
1565:P13501
1544:P13236
1519:P10147
1498:P13500
1406:α-helix
1261:Ligands
1161:ligands
1084:viruses
969:or the
963:viruses
933:to the
904:called
883:viruses
881:, some
748:scholar
674:A:22-87
92:PROSITE
73:PF00048
5935:CMKLR1
5906:Others
5882:CX3CR1
5824:C (XC)
5785:LIH383
5780:CCX771
5749:CXCL16
5728:CXCL13
4704:IL1F10
4601:IFNA21
4596:IFNA17
4591:IFNA16
4586:IFNA14
4581:IFNA13
4576:IFNA10
4233:Type I
4189:TNFSF9
4184:TNFSF8
4179:TNFSF7
4174:TNFSF6
4164:TNFSF4
4099:CX3CL1
4083:CXCL17
4078:CXCL16
4073:CXCL15
4068:CXCL14
4063:CXCL13
4058:CXCL12
4053:CXCL11
4048:CXCL10
3870:/MIP1β
3864:/MIP1α
3756:
3746:
3738:
3689:
3679:
3640:
3632:
3567:
3525:
3515:
3489:Nature
3467:
3432:
3397:
3356:
3348:
3312:
3304:
3266:
3232:
3222:
3183:
3175:
3137:
3129:
3094:
3086:
3078:
3029:
3021:
2982:
2972:
2964:
2895:RANTES
2831:enzyme
2806:serine
2783:CX3CR1
2736:(or CX
2689:CXCL13
2626:RANTES
2555:CX3CR1
2544:CX3CL1
2440:CXCL17
2426:SRPSOX
2423:Scyb16
2419:CXCL16
2405:Scyb15
2401:CXCL15
2387:Scyb14
2383:CXCL14
2366:Scyb13
2362:CXCL13
2341:Scyb12
2337:CXCL12
2316:Scyb11
2312:CXCL11
2295:Scyb10
2291:CXCL10
2188:ENA-78
2171:CXCR3B
2054:Scya28
2033:Scya27
2012:Scya26
1991:Scya25
1970:Scya24
1949:Scya23
1928:Scya22
1907:Scya21
1886:Scya20
1865:Scya19
1847:Scya18
1826:Scya17
1793:Scya16
1768:Scya15
1747:Scya14
1718:Scya13
1700:Scya12
1671:Scya11
1557:RANTES
1532:MIP-1β
1511:MIP-1a
1398:-helix
1390:N-loop
1185:B-cell
1153:thymus
1139:homing
1123:Homing
1116:CXCL10
1092:CXCL-8
1062:CXCL13
1058:CXCL12
967:silica
796:χῠμείᾱ
750:
743:
736:
729:
721:
171:PDBsum
145:
135:
117:SUPFAM
59:Symbol
5914:CCBP2
5807:PAMs:
5759:CXCR7
5738:CXCR6
5717:CXCR5
5660:CXCR4
5608:CXCR3
5590:NAMs:
5548:CXCL7
5543:CXCL6
5538:CXCL5
5533:CXCL3
5528:CXCL2
5508:CXCR2
5490:NAMs:
5463:CXCL6
5448:CXCR1
5399:CCL25
5394:CCL21
5389:CCL19
5378:CCR11
5368:CCL28
5363:CCL27
5352:CCR10
5342:CCL25
5321:CCL16
5295:CCL21
5290:CCL19
5269:CCL20
5215:NAMs:
5208:CCL16
5203:CCL14
5198:CCL13
5193:CCL11
5141:CCL22
5136:CCL17
5105:CCL28
5100:CCL26
5095:CCL24
5090:CCL18
5085:CCL15
5080:CCL13
5075:CCL11
5041:NAMs:
5034:CCL16
5029:CCL12
4998:CCL23
4993:CCL16
4988:CCL15
4983:CCL14
4766:KITLG
4754:Other
4740:IL17A
4699:IL1F9
4694:IL1F8
4689:IL1F7
4684:IL1F6
4679:IL1F5
4616:IFNW1
4606:IFNB1
4571:IFNA8
4566:IFNA7
4561:IFNA6
4556:IFNA5
4551:IFNA4
4546:IFNA2
4541:IFNA1
4420:Other
4323:gp130
4312:GMCSF
4092:CX3CL
4043:CXCL9
4033:CXCL7
4028:CXCL6
4023:CXCL5
4018:CXCL4
4013:CXCL3
4008:CXCL2
4002:CXCL1
3986:CCL28
3981:CCL27
3976:CCL26
3971:CCL25
3966:CCL24
3961:CCL23
3956:CCL22
3951:CCL21
3946:CCL20
3941:CCL19
3935:CCL18
3930:CCL17
3925:CCL16
3920:CCL15
3915:CCL14
3910:CCL13
3905:CCL12
3900:CCL11
3858:/MCP1
3749:18399
3740:48922
3736:JSTOR
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3354:S2CID
3310:S2CID
3252:(PDF)
3181:S2CID
3135:S2CID
3092:S2CID
2712:-β).
2645:aging
2641:CCL11
2548:Scyd1
2505:Scyc2
2484:Scyc1
2444:VCC-1
2430:CXCR6
2373:CXCR5
2352:CXCR7
2348:CXCR4
2327:CXCR7
2323:CXCR3
2302:CXCR3
2281:CXCR3
2274:Scyb9
2270:CXCL9
2260:CXCR2
2256:CXCR1
2249:Scyb8
2245:CXCL8
2231:Scyb7
2227:CXCL7
2217:CXCR2
2213:CXCR1
2209:GCP-2
2206:Scyb6
2202:CXCL6
2192:CXCR2
2185:Scyb5
2181:CXCL5
2164:Scyb4
2160:CXCL4
2150:CXCR2
2143:Scyb3
2139:CXCL3
2129:CXCR2
2122:Scyb2
2118:CXCL2
2108:CXCR2
2101:Scyb1
2097:CXCL1
2065:CCR10
2050:CCL28
2040:CCR10
2029:CCL27
2008:CCL26
1987:CCL25
1966:CCL24
1945:CCL23
1924:CCL22
1903:CCL21
1882:CCL20
1861:CCL19
1843:CCL18
1822:CCL17
1789:CCL16
1764:CCL15
1743:CCL14
1714:CCL13
1703:MCP-5
1696:CCL12
1667:CCL11
1650:Scya9
1646:CCL10
1620:MCP-2
1617:Scya8
1596:Scya7
1575:Scya6
1554:Scya5
1529:Scya4
1508:Scya3
1490:MCP-1
1487:Scya2
1467:Scya1
1281:CCL11
1269:CXCL8
1237:CCL22
1215:CXCL8
1149:Basal
1112:CCL11
1082:, or
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1050:CCL25
1046:CCL21
1042:CCL20
1038:CCL19
1034:CCL14
995:blood
820:cells
793:
755:JSTOR
741:books
113:SCOPe
104:SCOP2
5873:CX3C
5833:XCR1
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5316:CCL1
5305:CCR8
5279:CCR7
5258:CCR6
5188:CCL8
5162:CCR5
5115:CCR4
5070:CCL7
5054:CCR3
5024:CCL8
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4973:CCL6
4952:CCR1
4886:IL13
4881:IL10
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4845:IFNγ
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4798:cell
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4260:IL15
4142:TNFA
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4115:XCL1
3995:CXCL
3895:CCL9
3890:CCL8
3885:CCL7
3880:CCL6
3874:CCL5
3868:CCL4
3862:CCL3
3856:CCL2
3851:CCL1
3754:PMID
3687:PMID
3630:PMID
3587:link
3565:PMID
3523:PMID
3465:PMID
3430:PMID
3395:PMID
3346:PMID
3302:PMID
3264:PMID
3230:PMID
3173:PMID
3127:PMID
3084:PMID
3076:ISSN
3027:PMID
3019:ISSN
2980:PMID
2962:ISSN
2808:and
2787:XCR1
2775:CXCR
2761:are
2634:CCR5
2606:and
2596:CCL9
2529:Gene
2526:Name
2512:XCR1
2501:XCL2
2491:XCR1
2480:XCL1
2465:Gene
2462:Name
2167:PF-4
2082:Gene
2079:Name
2061:CCR3
2019:CCR3
1998:CCR9
1977:CCR3
1956:CCR1
1935:CCR4
1914:CCR7
1893:CCR6
1872:CCR7
1833:CCR4
1812:CCR8
1808:CCR5
1804:CCR2
1800:CCR1
1779:CCR3
1775:CCR1
1754:CCR1
1733:CCR5
1729:CCR3
1725:CCR2
1686:CCR5
1682:CCR3
1678:CCR2
1657:CCR1
1642:CCL9
1632:CCR5
1628:CCR2
1624:CCR1
1613:CCL8
1603:CCR2
1592:CCL7
1582:CCR1
1571:CCL6
1561:CCR5
1550:CCL5
1540:CCR5
1536:CCR1
1525:CCL4
1515:CCR1
1504:CCL3
1494:CCR2
1483:CCL2
1474:CCR8
1463:CCL1
1448:Gene
1445:Name
1416:and
1349:and
1344:gene
1289:CCR3
1285:CCL5
1265:lung
1211:CCL5
1181:skin
1108:CCL5
1104:CCL4
1100:CCL3
1096:CCL2
1072:IL-1
1060:and
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727:news
671:1vmc
665:2sdf
659:1a15
652:1qg7
646:1sdf
640:1lv9
634:1o80
628:1o7y
622:1o7z
616:1rjt
610:1plf
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562:1mi2
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526:1tvx
520:1il8
514:1ilq
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310:1u4r
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292:1b50
286:1b53
280:1hum
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262:1eig
256:1eih
250:2eot
244:1eot
238:1esr
232:1ncv
226:1bo0
220:1dom
214:1ml0
208:1mca
201:1don
195:1dol
189:1dok
164:PDBj
160:PDBe
143:ECOD
133:Pfam
109:3il8
68:Pfam
5671:MIF
5439:CXC
4876:IL6
4871:IL5
4866:IL4
4812:IL1
4783:MIF
4362:LIF
4357:OSM
4331:IL6
4307:IL5
4302:IL3
4279:IL9
4274:IL7
4265:IL4
4256:IL2
4214:EDA
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4108:XCL
4004:/KC
3844:CCL
3744:PMC
3726:doi
3677:PMC
3669:doi
3665:238
3622:doi
3610:270
3557:doi
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3385:doi
3381:111
3338:doi
3294:doi
3290:229
3220:PMC
3212:doi
3165:doi
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3066:hdl
3058:doi
3011:doi
3007:354
2970:PMC
2954:doi
2950:317
2907:HIV
2903:HIV
2779:CCR
2592:CCL
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1418:50s
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